TWAS
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Models
Genes
Traits
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Traits
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Arm fat-free mass (right)
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chr6:151,477,414-153,695,725
Best TWAS P=2.04e-08 · Best GWAS P=3.55e-21 conditioned to 3.65e-16
151.5M
152M
152.5M
153M
153.5M
0
5
10
15
20
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
SYNE1
0.12
0.01
blup
875
0.05
6.9e-07
1.7
5.6
2.0e-08
0.26
0.63
0.08
TRUE
3
The Cancer Genome Atlas
Lung Adenocarcinoma
RMND1
0.05
0.06
lasso
2
0.07
4.3e-08
5.6
-5.3
1.1e-07
-0.04
0.00
1.00
TRUE
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
RGS17
0.02
0.02
enet
5
0.02
1.8e-04
5.2
-5.2
2.3e-07
0.02
0.01
0.98
TRUE
4
The Cancer Genome Atlas
Skin Cutaneous Melanoma
RMND1
0.16
0.15
enet
7
0.09
2.7e-03
5.6
-5.2
2.4e-07
-0.04
0.00
0.95
FALSE