Best TWAS P=1e-11 · Best GWAS P=2.17e-15 conditioned to 1.11e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | SLC22A3 | 0.13 | 0.06 | enet | 7 | 0.09 | 1.3e-05 | -5.3 | -5.5 | 4.0e-08 | -0.63 | 0.53 | 0.46 | FALSE |
2 | GTEx | Brain Caudate basal ganglia | SLC22A3 | 0.15 | 0.10 | enet | 39 | 0.11 | 5.6e-04 | -6.7 | -6.8 | 1.0e-11 | -0.71 | 0.05 | 0.88 | TRUE |
3 | GTEx | Brain Frontal Cortex BA9 | SLC22A3 | 0.26 | 0.08 | lasso | 6 | 0.05 | 1.5e-02 | -3.9 | -5.5 | 3.2e-08 | -0.63 | 0.15 | 0.59 | FALSE |
4 | GTEx | Esophagus Mucosa | SLC22A3 | 0.19 | 0.08 | enet | 47 | 0.12 | 1.7e-08 | 5.4 | -6.3 | 3.3e-10 | -0.58 | 0.64 | 0.36 | FALSE |
5 | GTEx | Nerve Tibial | SLC22A3 | 0.20 | 0.10 | lasso | 7 | 0.13 | 3.2e-09 | -5.2 | -5.6 | 2.5e-08 | -0.56 | 0.99 | 0.00 | FALSE |
6 | GTEx | Ovary | SLC22A3 | 0.33 | 0.29 | lasso | 6 | 0.23 | 2.8e-06 | -5.1 | -5.3 | 1.1e-07 | -0.65 | 0.12 | 0.79 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | SLC22A3 | 0.15 | 0.05 | lasso | 9 | 0.05 | 9.9e-04 | -3.2 | -5.6 | 1.7e-08 | -0.65 | 0.11 | 0.86 | FALSE |
8 | GTEx | Testis | SLC22A3 | 0.19 | 0.01 | lasso | 14 | 0.05 | 2.6e-03 | -7.6 | -5.4 | 6.6e-08 | -0.66 | 0.14 | 0.84 | FALSE |
9 | ROSMAP | Brain Pre-frontal Cortex | SLC22A3 | 0.14 | 0.20 | lasso | 10 | 0.19 | 2.4e-24 | -5.4 | -5.7 | 1.2e-08 | -0.67 | 1.00 | 0.00 | FALSE |
10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | LPAL2 | 0.07 | 0.00 | blup | 74 | 0.04 | 1.1e-03 | -3.6 | 5.6 | 2.3e-08 | 0.75 | 0.04 | 0.51 | FALSE |