Best TWAS P=2.87e-18 · Best GWAS P=1.09e-17 conditioned to 0.0267
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DNAJC30 | 0.13 | 0.07 | enet | 32 | 0.07 | 2.7e-09 | 5.74 | 6.0 | 2.7e-09 | 0.24 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | MLXIPL | 0.11 | 0.07 | enet | 16 | 0.07 | 1.6e-06 | 7.58 | 8.5 | 2.2e-17 | 0.88 | 0.03 | 0.97 | FALSE |
3 | GTEx | Adipose Visceral Omentum | MLXIPL | 0.16 | 0.02 | lasso | 3 | 0.03 | 7.8e-03 | 7.79 | 8.3 | 1.5e-16 | 0.81 | 0.14 | 0.84 | FALSE |
4 | GTEx | Adipose Visceral Omentum | NSUN5 | 0.07 | 0.03 | enet | 11 | 0.04 | 4.0e-03 | 8.34 | 7.3 | 2.3e-13 | 0.71 | 0.02 | 0.77 | FALSE |
5 | GTEx | Breast Mammary Tissue (Female) | TBL2 | 0.26 | -0.01 | enet | 32 | 0.00 | 3.3e-01 | 2.19 | -5.2 | 2.5e-07 | -0.27 | 0.02 | 0.31 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | MLXIPL | 0.13 | 0.06 | enet | 6 | 0.09 | 2.2e-07 | 8.42 | 8.7 | 3.2e-18 | 0.82 | 0.02 | 0.98 | FALSE |
7 | GTEx | Heart Left Ventricle | MLXIPL | 0.14 | 0.00 | enet | 24 | 0.01 | 1.3e-01 | 0.36 | 5.7 | 1.6e-08 | 0.52 | 0.10 | 0.49 | FALSE |
8 | GTEx | Lung | MLXIPL | 0.10 | 0.07 | enet | 14 | 0.07 | 6.3e-06 | 7.58 | 6.5 | 7.4e-11 | 0.65 | 0.09 | 0.78 | FALSE |
9 | GTEx | Skin Not Sun Exposed Suprapubic | MLXIPL | 0.11 | 0.11 | lasso | 3 | 0.06 | 2.7e-04 | 8.42 | 8.3 | 1.3e-16 | 0.84 | 0.02 | 0.97 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | MLXIPL | 0.12 | 0.09 | lasso | 4 | 0.06 | 6.1e-06 | 8.37 | 8.4 | 3.5e-17 | 0.86 | 0.03 | 0.97 | FALSE |
11 | GTEx | Spleen | NCF1B | 0.22 | 0.10 | enet | 9 | 0.08 | 5.1e-03 | 8.02 | -8.2 | 1.6e-16 | -0.62 | 0.03 | 0.53 | FALSE |
12 | GTEx | Testis | MLXIPL | 0.10 | 0.00 | lasso | 3 | 0.00 | 3.3e-01 | 5.62 | 7.6 | 4.1e-14 | 0.66 | 0.04 | 0.35 | FALSE |
13 | GTEx | Testis | VPS37D | 0.15 | 0.01 | lasso | 5 | 0.03 | 2.7e-02 | -4.98 | -5.4 | 8.1e-08 | -0.24 | 0.13 | 0.06 | FALSE |
14 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | 7.58 | 8.7 | 2.9e-18 | 0.83 | 0.02 | 0.98 | TRUE |
15 | METSIM | Adipose | BCL7B | 0.10 | 0.02 | enet | 20 | 0.05 | 1.2e-07 | 7.79 | 5.8 | 8.1e-09 | 0.66 | 0.02 | 0.98 | FALSE |
16 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | 8.28 | 8.7 | 4.5e-18 | 0.80 | 0.04 | 0.96 | FALSE |
17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MLXIPL | 0.06 | 0.05 | lasso | 2 | 0.05 | 5.1e-10 | 8.34 | 8.0 | 1.3e-15 | 0.67 | 0.00 | 1.00 | FALSE |
18 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | BCL7B | 0.08 | 0.04 | blup | 5 | 0.06 | 1.0e-03 | 8.34 | -5.3 | 1.2e-07 | -0.35 | 0.00 | 0.90 | FALSE |
19 | The Cancer Genome Atlas | Lung Adenocarcinoma | MLXIPL | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.3e-03 | 8.34 | 8.3 | 7.2e-17 | 0.67 | 0.00 | 0.97 | FALSE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLXIPL | 0.08 | 0.05 | enet | 4 | 0.05 | 5.3e-06 | 8.34 | 7.2 | 6.4e-13 | 0.64 | 0.00 | 1.00 | FALSE |
21 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | CALN1 | 0.37 | 0.04 | enet | 10 | 0.25 | 3.1e-07 | -6.22 | 5.2 | 2.1e-07 | 0.02 | 0.01 | 0.96 | TRUE |
22 | The Cancer Genome Atlas | Thyroid Carcinoma | BCL7B | 0.05 | 0.01 | blup | 5 | 0.03 | 1.3e-03 | 8.34 | -7.1 | 1.2e-12 | -0.38 | 0.00 | 0.63 | FALSE |