Hub : Genes

TBL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2140	0.0770	1.9e-02	0.085	0.005	0.084	0.096	0.081	1.6e-10	7.5e-02	1.9e-10	1.1e-11	4.1e-10
2	GTEx	Artery Aorta	0.5920	0.0800	7.6e-06	0.242	NA	0.345	NA	0.321	1.5e-13	NA	9.0e-20	NA	2.9e-18
3	GTEx	Artery Tibial	0.6450	0.0496	1.1e-13	0.242	NA	0.338	NA	0.369	6.0e-19	NA	2.9e-27	NA	2.9e-30
4	GTEx	Brain Caudate basal ganglia	0.2360	0.1000	5.2e-03	0.023	NA	0.080	NA	0.044	7.2e-02	NA	2.6e-03	NA	2.1e-02
5	GTEx	Breast Mammary Tissue	0.4070	0.1150	1.4e-03	0.136	NA	0.177	NA	0.103	1.8e-07	NA	2.0e-09	NA	6.2e-06
6	GTEx	Breast Mammary Tissue (Male)	0.6513	0.1156	6.7e-04	0.287	NA	0.194	NA	0.267	2.2e-07	NA	2.9e-05	NA	6.4e-07
7	GTEx	Breast Mammary Tissue (Female)	0.2607	0.1212	9.0e-03	-0.006	NA	0.000	NA	-0.007	5.5e-01	NA	3.3e-01	NA	5.6e-01
8	GTEx	Nerve Tibial	0.6187	0.0852	5.0e-06	0.139	NA	0.308	NA	0.326	4.9e-10	NA	3.4e-22	NA	1.1e-23
9	METSIM	Adipose	0.0877	0.0492	2.2e-02	0.023	0.008	0.060	0.031	0.024	1.8e-04	2.1e-02	2.7e-09	1.6e-05	1.2e-04
10	YFS	Blood	0.1296	0.0390	2.0e-07	0.032	0.024	0.041	0.038	0.034	7.1e-11	1.9e-08	1.9e-13	2.2e-12	2.4e-11
11	TCGA	Soft Tissue Sarcoma	0.1560	0.0680	2.5e-04	-0.001	0.081	0.090	NA	0.065	3.5e-01	1.5e-05	5.1e-06	NA	1.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.2	0.3	0.7	0.1	0.4	0.6	-0.9	-0.5	0.3	-0.9	0.7	0.4	0.5	-0.4
Bipolar Disorder or Schizophrenia	0.6	1.4	3.6	0.3	1.0	1.4	-1.2	1.6	1.9	0.5	1.1	1.3	1.3	-0.5
Depressed Affect (Nagel 2018)	0.4	0.9	3.4	-0.4	-0.1	-0.4	-1.8	-1.5	-0.1	-0.9	0.2	0.6	0.7	1.4
Depression (Nagel 2018)	0.4	0.6	1.9	-0.6	0.3	-0.9	0.1	-1.4	-0.6	-0.3	0.2	-0.9	-0.1	-1.4
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.2	-1.0	-2.0	-1.5	0.3	-1.3	-1.9	-1.5	-1.8	-1.2	-1.2	-2.1
Neuroticism (Nagel 2018)	0.4	0.9	2.8	-0.3	-0.4	-0.4	-1.7	-1.4	-0.2	-1.1	0.4	0.7	1.3	1.0
Schizophrenia (2018)	0.9	1.9	6.0	0.4	0.9	1.4	-0.9	2.4	2.2	1.4	0.8	1.4	1.2	-0.4
Schizophrenia vs Biploar Disorder	1.0	1.3	3.4	0.4	0.0	1.3	-1.1	1.1	1.8	0.7	1.2	1.7	1.0	-0.7
Worry (Nagel 2018)	0.2	0.4	1.1	0.2	-0.4	-0.6	-0.8	-1.1	-0.6	-0.9	0.4	0.4	1.0	-0.3
Alzheimer’s Disease (in mother)	1.8	2.1	3.1	-1.2	-1.1	-1.5	1.7	-1.8	-1.7	-1.4	-1.4	-1.7	-1.8	-0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.6	0.3	0.2	0.2	0.3	0.3	0.4	0.1	0.5	0.3	0.0
Alzheimer’s Disease (including proxy)	1.0	1.5	5.9	-0.6	-0.3	-1.0	2.4	-1.3	-1.2	-1.0	-1.1	-1.3	-1.3	-0.5
Crohns Disease (2017)	0.7	1.5	7.1	0.6	0.9	1.2	-0.4	0.3	1.9	0.6	1.3	0.9	-0.2	2.7
Irritable Bowel Disease (IBD)	0.2	0.5	2.7	-0.2	-0.0	0.3	-0.6	0.1	1.2	0.6	0.5	-0.2	-0.8	1.6
Ulcerative Colitis (UC)	0.2	0.5	1.3	-0.8	-0.8	-0.6	0.4	-0.1	0.1	0.6	-0.4	-1.1	-1.1	0.3
Major Depression (MDD)	0.7	0.8	1.8	0.7	1.1	1.1	-0.5	0.0	0.9	-0.3	1.2	1.2	1.4	0.2
Reaction Time	0.6	1.1	2.8	0.4	1.1	0.6	1.6	1.3	0.7	0.6	0.6	1.7	1.5	-0.5
Verbal and Numeric Reasoning (VNR)	2.3	5.6	10.3	-2.4	-2.9	-2.9	-1.1	-2.0	-2.8	-2.3	-3.2	-2.0	-1.7	-2.2
Breast Cancer	0.6	1.4	4.4	-1.3	-0.3	-1.6	1.4	-1.0	-2.1	0.7	-1.6	-0.4	-0.8	-0.6
Ovarian Cancer	0.9	1.1	3.8	1.6	0.1	1.0	-1.9	0.9	0.7	1.1	1.4	0.6	-0.5	-0.1
Prostate Cancer	1.2	1.6	3.2	0.7	1.5	1.5	-0.1	1.1	1.8	1.1	1.3	1.5	1.1	1.5
Age at First Birth	0.7	1.0	2.4	-1.6	-1.4	-1.2	-0.2	-1.0	-0.9	0.0	-1.1	-1.3	-0.7	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.8	0.9	0.0	0.2	0.6	0.3	-0.1	0.7	0.5	0.6	0.3	-0.4
Coronary Artery Disease (CAD)	0.0	0.0	0.4	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	0.7
Crohns Disease (2012)	0.5	0.8	1.7	0.3	1.3	1.1	-0.0	0.9	1.3	1.0	0.8	1.1	0.6	-0.7
Mean Putamen Volume	0.8	0.9	3.6	0.5	-0.1	0.2	-1.6	-0.8	0.1	-1.3	0.7	1.0	1.9	-0.2
Fasting Glucose	1.7	2.0	4.6	-1.0	-1.4	-1.8	1.5	-1.8	-2.1	-0.5	-1.7	-1.2	-0.7	-0.9
HbA1C	0.4	0.5	1.8	0.9	-0.2	-0.2	-1.3	-0.5	-0.4	-1.2	0.1	0.5	-0.5	-0.2
HDL Cholesterol	0.7	1.2	5.6	0.3	-0.8	0.0	2.0	-0.8	-0.0	-2.4	-0.2	-0.4	0.7	1.3
LDL Cholesterol	0.1	0.1	0.5	0.7	0.1	0.2	0.1	0.2	-0.2	0.1	-0.0	0.3	0.4	0.4
Lupus	2.4	3.6	6.3	2.2	2.1	2.0	0.4	1.5	1.6	1.6	2.5	2.5	2.0	1.4
Neuroticism (2016)	2.9	4.2	7.9	2.6	2.6	2.3	-1.4	0.9	2.1	-0.3	2.8	2.6	2.3	0.4
Primary Biliary Cirrhosis	2.7	3.8	5.6	2.4	2.3	1.9	0.2	2.1	2.1	1.2	2.0	2.0	1.9	2.2
Rheumatoid Arthritis	0.7	0.9	1.9	1.3	0.9	1.2	-0.4	0.0	0.7	-0.3	1.4	1.4	1.3	0.4
Schizophrenia (2014)	0.2	0.5	2.0	-0.4	0.3	0.3	-1.4	1.1	1.0	0.8	0.1	0.4	0.1	-0.6
Triglycerides	14.7	24.0	66.7	2.8	5.5	3.6	-6.9	6.0	4.6	8.2	4.0	4.2	0.3	-3.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.1
Ulcerative Colitis	0.3	0.5	1.7	0.3	0.4	0.3	0.6	-1.3	0.8	-1.1	0.6	0.4	0.5	-0.1
Blood Eosinophil Count	0.3	2.6	8.8	1.6	1.0	0.6	2.0	-1.0	-0.3	-2.6	0.7	0.6	1.6	-3.0
Blood Platelet Count	0.3	4.0	19.7	-0.7	0.5	-0.8	-1.6	-0.7	-0.4	4.4	0.0	-0.6	-2.4	3.8
Blood Red Count	0.0	0.2	0.5	0.4	0.4	0.7	0.1	0.7	0.2	0.1	-0.1	0.7	-0.0	0.3
Blood White Count	0.2	1.5	4.2	1.1	1.6	0.4	-1.4	0.3	0.5	2.0	0.9	1.3	-0.4	1.9
Heel T-Score	0.1	1.1	2.7	0.1	-1.3	-0.9	1.2	-1.2	-1.6	-0.9	-0.5	-0.9	0.2	-1.6
BMI	0.9	5.4	15.4	3.9	2.0	2.5	3.4	0.2	0.6	-2.5	2.4	1.2	2.0	-2.0
Height	0.5	9.9	34.5	-2.4	-1.0	-2.4	2.3	-4.4	-2.6	-5.0	-2.2	-0.7	0.4	-5.9
Waist Hip Ratio (WHR)	0.8	3.7	17.3	0.6	3.4	0.7	0.5	2.7	0.7	4.2	-0.1	1.7	-0.8	0.4
Systolic Blood Pressure	0.4	1.9	5.2	1.8	0.2	0.9	-1.7	-1.7	-0.1	-0.2	0.7	1.6	1.8	2.3
Smoking Status	1.3	3.0	4.6	1.7	1.8	2.0	0.9	1.9	2.0	0.1	2.0	2.1	2.0	-1.3
Allergy or Eczema	0.7	1.8	8.0	-1.1	-1.2	-1.5	0.6	-0.7	-1.9	-0.2	-1.3	-0.4	-0.3	-2.8
Cardiovascular Disease	0.3	0.9	4.7	1.5	2.2	0.4	-0.5	0.1	-0.1	0.9	0.7	0.9	0.3	0.4
Hypothyroidism (self reported)	1.3	2.9	7.6	2.0	1.9	1.8	0.1	2.1	1.8	0.7	1.6	2.8	1.5	-0.3
Respiratory disease	0.3	0.7	5.7	0.3	0.0	0.1	0.6	-0.8	-0.0	-2.4	0.3	-0.3	-0.1	-0.8
Type 2 Diabetes (T2D) (2018)	1.4	2.7	14.2	0.8	0.7	0.4	3.8	-0.8	-0.5	-1.9	-0.4	1.1	1.7	-2.4
Lung FEV1/FVC ratio	0.8	4.2	25.0	0.1	3.1	1.0	1.7	-2.4	0.5	-5.0	-0.1	0.5	1.4	-0.2
Lung FVC	0.2	1.0	5.7	-0.5	0.0	0.0	1.3	-1.1	0.6	-2.4	-0.4	0.2	1.1	-0.0
Neuroticism	0.4	1.0	2.4	1.0	0.3	0.6	-1.3	-0.4	0.6	-0.8	1.4	1.6	1.5	0.8
Chronotype (morning person)	0.9	2.2	7.7	1.4	1.2	1.7	0.8	0.3	1.0	0.8	1.3	1.7	1.7	2.8
Hair Pigment	0.1	3.4	19.8	1.8	1.8	0.6	-4.5	-0.6	0.1	0.8	1.8	1.6	-0.9	1.8
Tanning	0.1	1.3	4.8	0.6	0.1	0.8	1.1	0.2	0.8	-2.2	0.2	0.6	1.7	-1.9
Hand grip strength (left)	0.2	0.6	2.3	0.0	0.0	-0.3	0.8	-1.3	-1.0	-1.5	-0.1	-0.4	0.7	-0.8
Number of treatments/medications taken	4.2	7.6	17.6	2.9	4.2	3.3	1.4	2.5	3.1	1.3	2.9	3.3	2.9	-0.1
Average weekly spirits intake	1.9	2.3	5.4	2.3	2.0	2.1	0.8	0.4	1.4	-1.0	2.0	1.6	1.0	0.5
Sensitivity / hurt feelings	0.3	0.6	1.5	-0.8	-0.7	-0.8	0.9	-0.5	-0.4	-0.4	-0.9	-0.9	-0.5	1.2
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.9	-1.3	-0.6	-2.1	0.0	-1.8	-1.7	-0.3	-0.9	-2.2	-1.6	-2.0
Hearing difficulty/problems: Yes	1.0	1.6	9.7	0.3	0.8	0.5	1.8	0.3	0.3	-1.6	0.6	-0.3	0.1	-3.1
Relative age of first facial hair	1.6	3.4	8.2	-1.5	-1.8	-1.6	-1.3	1.1	-1.2	2.9	-1.4	-2.3	-2.7	1.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.8	0.6	1.0	0.8	1.3	0.8	0.9	0.8	0.5	0.6	1.1	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.7	-0.8	-0.7	-0.3	0.8	-0.9	-0.4	-1.3	-0.5	-1.1	-0.4	-0.8
Ever had hysterectomy (womb removed)	0.9	1.0	2.4	0.3	0.3	1.1	0.6	1.6	1.3	1.3	0.8	-0.1	-0.6	1.5
Systolic blood pressure, automated reading	0.9	2.7	6.5	2.3	0.9	1.4	-1.3	-0.8	0.4	-0.6	1.4	2.2	2.2	2.6
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	2.3	-0.1	-0.1	-0.3	-0.2	-0.9	-0.6	-0.8	-0.2	0.2	0.6	-1.5
Angina	0.6	0.8	2.0	1.2	1.4	1.0	0.4	-0.1	0.3	-0.6	1.3	1.0	0.9	-0.7
Medication for hormone replacement therapy	1.1	1.2	7.7	0.7	0.8	-0.1	2.8	-0.1	-0.6	-0.5	0.1	0.6	1.0	-1.6
Vitamin and mineral supplements	0.7	0.9	3.5	0.3	-1.0	-0.8	0.1	-0.7	-1.3	-0.6	-0.7	-1.2	-1.9	0.5
Supplements: Zinc	0.5	0.5	1.0	0.8	1.0	0.8	0.2	0.6	1.0	-0.0	0.7	0.6	0.9	-0.7
Medication: Co-codamol	1.5	1.7	6.0	1.9	2.4	1.6	0.3	0.4	1.3	-0.8	1.6	1.0	0.3	0.5
Medication: Metformin	0.8	1.2	4.8	-1.0	-1.0	-0.5	2.2	-1.3	-1.0	-1.2	-0.9	-0.1	0.4	-0.8
Diabetes (father)	1.9	2.4	12.2	-0.1	0.5	-0.6	1.4	-2.5	-1.1	-3.5	-0.8	-0.2	0.1	-1.7
Diabetes (mother)	0.4	0.5	2.3	-0.4	-0.2	-0.2	0.2	1.2	0.0	1.1	-0.4	-0.3	-0.0	-1.5
Severe depression (siblings)	0.9	1.0	5.1	0.8	-0.4	-1.2	-1.1	-0.5	-1.6	-0.1	-0.4	0.2	0.1	-2.3
Pack years adult smoking proportion	0.4	0.6	4.2	-0.0	0.9	-0.1	-1.1	0.4	0.4	-0.2	0.1	-0.1	-0.6	2.1
Impedance of leg (right)	0.4	2.2	10.7	-0.8	0.7	-0.0	-1.6	1.0	0.8	3.3	-0.0	1.1	-0.8	2.4
Leg fat-free mass (left)	0.8	4.3	18.7	1.6	0.8	1.0	1.8	-1.3	-0.1	-4.3	1.1	0.4	1.9	-3.7
Trunk fat percentage	1.4	5.7	13.7	3.4	3.0	3.1	-0.0	-0.5	2.0	-1.9	3.7	2.5	1.7	1.4
Hand grip strength (right)	0.3	0.8	2.7	1.2	1.1	0.3	0.2	-0.4	-0.3	-1.6	0.6	0.4	1.2	-1.3
Townsend deprivation index at recruitment	0.4	0.6	3.5	0.6	0.1	0.6	-1.9	0.5	0.5	-0.5	0.9	0.1	-0.5	0.2
Current tobacco smoking	1.0	1.6	3.0	1.4	1.3	1.1	0.3	0.9	1.1	-0.8	1.3	1.6	1.5	-1.7
Average weekly fortified wine intake	3.7	4.3	8.6	1.7	1.9	2.5	0.8	2.9	2.7	2.0	2.0	2.2	1.4	1.7
Maternal smoking around birth	1.9	2.7	5.8	1.5	2.4	2.1	-0.3	0.7	2.2	0.4	2.4	2.1	1.1	0.5
Fed-up feelings	0.6	1.1	5.1	0.2	0.1	-0.4	-2.3	-1.6	-0.4	-1.3	0.4	0.1	0.7	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.6	-1.4	-0.3	-1.4	-0.6	-1.6	-0.9	-0.2	-0.1	-1.6	-0.3	-0.7
Relative age voice broke	1.1	1.7	5.1	-0.8	-1.7	-0.8	-1.7	0.9	-0.9	2.3	-0.5	-0.9	-1.0	1.6
Taking other prescription medications	0.5	0.7	1.4	1.1	1.1	0.9	0.5	1.2	0.6	0.9	0.8	0.7	0.5	-0.9
Age when periods started (menarche)	1.3	3.1	7.5	2.3	2.7	2.0	-0.6	1.2	1.8	0.9	2.5	1.5	1.4	1.0
Bilateral oophorectomy (both ovaries removed)	3.4	3.9	9.4	0.7	2.1	2.4	3.1	2.0	2.4	1.2	2.1	1.7	2.0	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.8	-0.4	-1.4	-1.3	1.9	-1.1	-1.9	-1.1	-1.0	-0.7	0.3	-1.3
Tinnitus: Yes, but not now, but have in the past	2.9	3.1	6.4	-2.5	-2.2	-1.9	0.6	-1.0	-1.7	-0.6	-2.3	-2.5	-1.3	-1.0
Qualifications: CSEs or equivalent	0.4	0.5	1.9	0.8	1.4	0.5	-0.8	-0.6	0.4	-0.8	0.6	0.6	0.2	0.2
Serious illness, injury or assault to yourself	0.6	0.7	3.7	-0.1	0.7	0.7	1.9	1.1	0.8	0.8	0.5	0.1	0.1	-0.9
High blood pressure	0.1	0.2	0.5	0.4	0.5	-0.2	0.2	-0.7	-0.7	0.7	0.0	0.2	0.3	0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.5	0.2	-0.3	-0.4	1.1	0.1	-1.1	0.1	-0.3	0.5	0.8	-1.6
Multivitamins +/- minerals	1.0	1.3	3.6	-0.0	1.5	1.2	0.1	0.8	1.9	-0.0	1.1	1.0	1.9	-0.9
Stomach or abdominal pain in last month	0.8	1.0	5.6	-0.8	-0.9	-1.3	-2.4	-0.3	-0.3	-0.3	-0.5	-0.9	-1.0	0.2
Supplements: Glucosamine	0.2	0.2	1.1	-0.1	0.6	-0.0	0.2	0.7	0.7	0.2	-0.4	0.2	-0.0	-1.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	7.8	0.2	0.7	0.3	-2.8	0.3	1.2	0.2	0.7	0.2	-0.3	-0.8
Medication: Atenolol	0.5	0.6	4.8	0.6	-0.1	-0.3	-2.2	-0.6	-0.7	-0.6	0.2	0.2	0.5	0.1
Medication: Levothyroxine sodium	2.9	5.0	10.0	2.5	2.1	2.4	0.1	2.9	2.6	1.2	2.3	3.2	2.6	0.6
Sitting height	1.0	6.8	20.4	-2.1	-2.4	-2.0	3.2	-2.6	-2.2	-4.5	-2.6	-2.1	0.1	-2.6
Chronic bronchitis/emphysema (father)	0.9	1.1	3.0	-0.6	-1.2	-1.3	-0.5	-0.2	-1.5	0.6	-0.9	-0.8	-1.1	-1.7
High blood pressure (mother)	0.5	0.7	3.2	1.0	0.0	-0.1	-1.0	-0.6	-0.8	0.3	0.6	0.9	0.7	1.8
Body mass index (BMI)	1.4	6.0	15.5	3.9	2.5	3.2	1.2	0.2	1.7	-2.9	3.4	2.0	2.3	-0.7
Impedance of leg (left)	0.4	2.1	9.9	-1.1	0.3	-0.3	-1.3	0.7	0.5	2.7	-0.4	0.9	-0.9	3.1
Leg predicted mass (left)	0.8	4.3	18.9	1.6	0.8	1.0	1.9	-1.3	-0.1	-4.3	1.1	0.4	2.0	-3.7
Trunk fat mass	1.3	5.7	12.3	3.5	2.8	3.0	0.8	-0.7	1.7	-2.9	3.5	2.3	2.0	0.0
Waist circumference	0.9	3.4	8.2	2.9	2.5	2.4	1.0	0.4	1.4	-1.5	2.6	1.6	1.4	-0.8
Number of incorrect matches in round	0.7	1.2	4.5	0.6	1.0	0.9	-0.8	0.8	1.1	2.1	1.4	1.3	0.4	-0.1
Past tobacco smoking	2.2	4.0	7.2	-1.5	-1.9	-2.7	-1.5	-2.7	-2.5	-1.3	-2.5	-1.9	-1.8	-0.5
Alcohol usually taken with meals	0.8	1.3	2.2	-1.2	-0.7	-1.5	0.9	-0.0	-1.2	1.4	-1.3	-1.1	-1.4	-0.7
Nervous feelings	1.9	3.5	7.6	-0.7	-2.5	-2.6	-1.9	-2.3	-2.8	-1.3	-1.7	-1.4	-0.9	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.9	-0.7	-0.5	-0.9	0.0	-0.9	-0.7	0.4	0.0	-0.2	0.9	1.4
Hearing difficulty/problems with background noise	0.7	1.1	5.2	-1.2	-0.6	-0.5	-0.3	-0.6	-0.2	-1.8	-0.2	-1.1	-0.4	-2.3
Hair/balding pattern: Pattern 2	1.7	2.1	6.6	0.9	1.5	1.5	-1.2	1.2	1.5	0.2	1.5	1.7	2.6	1.0
Had menopause	0.4	0.4	1.0	0.2	0.3	0.9	0.2	1.0	1.0	0.1	0.6	0.8	0.9	-0.3
Had other major operations	1.7	2.1	3.7	-1.1	-1.5	-1.2	1.8	-1.5	-1.1	-1.4	-1.4	-1.9	-1.8	-1.2
Forced vital capacity (FVC)	0.5	1.8	4.9	-1.8	-1.0	-1.3	1.4	-1.5	-0.4	-2.2	-1.6	-0.9	0.4	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	3.2	-0.6	-1.7	-1.3	0.3	-0.9	-1.8	-0.7	-0.8	-0.8	-0.3	-0.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.3	1.5	0.9	0.5	0.8	0.8	0.1	0.1	0.8	1.1	0.9	-0.3
Qualifications: None of the above	3.1	6.7	12.2	2.4	3.1	3.2	-1.5	2.1	3.1	0.5	3.5	3.2	2.7	1.3
Financial difficulties in last 2 years	0.7	0.9	4.9	-0.4	-0.2	-0.2	-0.1	-2.0	-0.1	-2.2	0.2	-0.6	-0.0	-0.5
Mouth/teeth dental problems	0.6	1.0	4.1	-0.1	-0.0	0.7	-1.7	0.7	1.0	0.4	0.3	0.7	1.0	2.0
Heart attack	0.5	0.6	1.7	1.0	1.3	0.8	0.2	-0.1	0.4	-0.0	0.6	1.0	1.1	0.3
Allergy	0.4	1.0	4.2	-0.1	0.6	0.2	-1.8	-0.0	0.8	0.4	0.2	-0.4	-1.4	2.0
Pain all over the body in last month	1.0	1.1	2.1	0.8	1.4	1.1	-0.4	1.1	1.2	0.5	1.1	1.0	1.4	0.4
Diabetes (self-reported)	1.1	1.7	6.1	-0.3	-0.3	-0.8	1.9	-1.5	-1.6	-1.5	-1.1	0.0	0.6	-2.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	2.0	1.3	1.4	0.9	-0.5	0.6	0.2	-0.1	0.8	1.4	1.3	-0.2
Medication: Ramipril	1.9	2.4	4.6	2.0	1.9	2.0	-0.6	1.0	1.5	0.5	2.1	2.0	1.4	-1.1
Medication: Simvastatin	0.3	0.5	1.5	0.7	1.2	0.1	0.9	0.1	-0.7	0.7	0.1	0.9	0.2	-0.6
Fluid intelligence score	1.5	3.0	5.0	-1.5	-1.8	-2.1	-0.6	-1.0	-1.9	-1.0	-2.1	-1.8	-2.2	-2.2
Illnesses of siblings	1.3	1.8	3.1	1.1	1.4	1.6	-1.6	0.8	1.7	-1.2	1.6	1.2	0.9	-1.4
Neuroticism score	0.3	0.7	2.5	0.1	-0.7	-0.9	-1.1	-1.6	-0.9	-1.1	0.1	0.0	0.3	0.2
Weight	1.1	5.3	14.2	3.0	2.1	2.4	1.7	-0.7	1.1	-3.8	2.6	1.7	2.4	-2.2
Impedance of arm (right)	0.9	4.1	14.9	-1.5	0.2	-1.0	-3.2	0.2	-0.0	3.9	-0.2	0.2	-2.1	3.4
Arm fat percentage (right)	1.5	6.0	15.3	3.9	3.2	3.2	-0.1	-0.1	1.9	-1.7	3.9	2.4	1.4	0.6
Trunk fat-free mass	1.0	5.6	27.7	0.6	0.3	0.2	3.1	-1.4	-0.8	-4.3	-0.0	-0.2	1.6	-5.3
Hip circumference	0.8	3.7	16.0	2.5	0.7	1.8	0.7	-1.3	0.9	-4.0	2.5	0.6	1.8	-1.1
Time employed in main current job	0.5	0.6	1.7	-0.6	-0.7	-0.9	-0.4	0.0	-0.7	-0.1	-1.2	-0.9	-1.3	0.8
Alcohol intake versus 10 years previously	1.1	1.6	6.7	1.4	1.2	0.9	-0.9	0.1	0.4	1.5	1.4	1.1	0.4	2.6
Father’s age at death	0.3	0.4	3.5	0.3	-0.5	-0.1	0.6	0.2	-0.2	0.2	-0.4	0.0	-0.0	-1.9
Worrier / anxious feelings	0.4	0.8	3.7	0.7	0.1	-0.1	0.5	-1.1	-0.1	-1.2	1.0	1.1	1.9	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	4.0	1.6	1.7	0.6	-1.0	-1.2	0.3	-2.0	1.9	0.5	1.2	-0.4
Falls in the last year	0.3	0.4	1.1	0.5	0.1	0.6	-0.2	0.6	0.8	0.6	1.1	-0.3	-0.9	-0.1
Hair/balding pattern: Pattern 3	0.6	0.9	4.9	0.1	0.1	-0.8	-0.7	0.4	-0.9	2.2	-0.4	0.2	-1.5	-0.5
Number of live births	0.7	1.0	3.8	-0.7	-1.3	-0.1	-0.4	0.7	0.5	1.1	0.0	-1.5	-2.0	-0.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	8.3	-1.3	0.2	-0.7	1.4	-1.5	0.1	-2.9	-1.1	-0.5	0.7	-0.6
Pulse rate	2.6	4.3	10.0	-2.8	-2.1	-3.0	-0.3	-1.2	-2.2	-0.1	-3.2	-2.0	-2.1	0.8
Happiness	4.0	4.9	10.6	-2.0	-3.0	-3.2	-0.4	-1.9	-2.9	-0.4	-2.9	-2.2	-2.1	-0.6
Noisy workplace	0.5	0.6	1.6	0.2	1.3	0.4	0.7	0.2	0.9	0.0	0.8	0.9	0.8	0.9
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.8	-1.1	-1.3	-1.0	1.1	-0.2	-0.6	0.2	-1.4	-1.6	-1.9	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.5	1.6	0.8	0.2	0.5	-0.8	-0.5	-0.0	1.2	0.9	1.5	-0.2
Mouth/teeth dental problems: Dentures	1.5	2.6	5.2	1.6	1.6	1.7	1.1	0.8	1.4	-0.2	1.4	2.2	2.0	-2.3
Asthma	0.3	0.6	3.8	0.4	-0.3	0.0	0.3	-1.0	-0.3	-2.0	0.2	-0.3	0.1	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	2.4	1.6	0.8	0.6	0.3	0.7	0.1	0.7	0.2	0.7	0.4	1.3
Medication: Cholesterol lowering	0.7	1.1	3.2	1.5	1.8	1.0	-0.7	0.4	0.7	0.3	1.1	1.2	1.0	0.9
Depression (self-reported)	0.7	0.9	2.7	0.4	1.4	0.6	-1.3	0.4	1.6	-0.6	1.3	-0.0	-0.3	-0.7
Medication: Lansoprazole	0.5	0.5	2.6	-0.5	0.2	0.0	-0.7	-0.3	0.6	-1.6	0.3	-0.8	-0.6	-1.0
Prospective memory result	5.0	6.1	14.8	3.9	3.2	2.8	-0.4	1.4	1.9	-0.4	3.3	3.2	2.6	0.6
Lung cancer (father)	0.5	0.6	2.7	1.2	0.2	0.6	-0.5	-0.6	0.2	-1.6	1.1	0.1	0.5	0.5
Illnesses of mother	0.4	0.5	2.2	-0.2	0.7	0.8	0.2	0.7	1.5	-0.4	0.7	-0.2	0.1	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	12.0	-1.8	-0.1	-1.1	0.9	-2.4	-0.3	-3.5	-1.7	-0.9	0.5	-0.3
Pulse wave Arterial Stiffness index	1.1	1.3	3.0	-1.7	-1.7	-1.1	0.3	0.8	-0.4	1.2	-1.4	-1.3	-1.3	0.4
Impedance of arm (left)	0.9	4.2	18.1	-1.1	0.0	-0.8	-3.1	0.0	0.3	3.6	-0.0	0.4	-1.7	4.3
Arm fat mass (right)	1.5	6.2	15.4	3.9	2.9	3.1	1.0	-0.3	1.6	-3.0	3.5	2.2	2.2	-0.8
Trunk predicted mass	1.0	5.7	27.9	0.5	0.2	0.2	3.2	-1.4	-0.8	-4.4	-0.0	-0.2	1.6	-5.3
Standing height	0.4	3.8	13.5	-1.9	-0.9	-1.7	1.4	-2.4	-1.5	-2.7	-1.6	-0.8	0.3	-3.7
Length of working week for main job	0.6	0.6	2.0	0.3	1.0	0.8	0.4	-1.2	0.5	-1.4	0.8	0.4	0.2	0.8
Exposure to tobacco smoke at home	0.7	0.8	3.0	-1.0	-0.5	-0.5	-1.2	0.2	-0.1	0.6	-0.5	-0.7	-1.3	1.7
Breastfed as a baby	0.2	0.3	0.9	0.5	-1.0	-0.2	-0.9	0.7	-0.1	0.7	-0.4	-0.2	-0.2	0.4
Tense / ‘highly strung’	0.6	1.0	4.4	1.6	0.4	-0.5	-2.1	-0.7	-1.2	-0.6	0.6	0.8	0.8	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.3	-1.6	-0.9	-1.4	-0.6	-1.3	-0.8	-1.0	-0.7	-1.8	-1.3	-0.8
Hair/balding pattern: Pattern 4	0.5	1.2	5.1	0.8	0.9	0.4	-2.2	-1.3	0.3	-1.6	0.8	0.7	-0.7	-0.7
Birth weight of first child	0.7	1.3	3.4	-1.2	-1.2	-1.1	1.1	-1.9	-1.3	-1.2	-0.7	-0.7	0.4	-1.1
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.3	0.5	0.2	0.6	0.2	0.8	-0.8	0.1	-0.0	0.8	0.5
Pulse wave reflection index	0.2	0.3	1.0	-0.3	-0.1	0.3	-0.6	1.0	0.8	0.8	0.1	-0.4	-0.3	0.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.6	0.1	-0.0	-0.5	-0.5	-1.0	-0.5	-1.1	-0.0	-0.4	-1.3	0.8
Loud music exposure frequency	1.7	1.8	6.5	-0.6	-0.8	-1.2	-0.9	-1.4	-1.5	-0.2	-0.7	-2.3	-2.5	0.3
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	7.5	-2.5	-1.9	-2.2	0.5	-2.6	-1.9	-2.1	-2.7	-2.3	-1.1	-0.4
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	-0.2	0.3	-0.9	0.8	0.0	-0.5	1.1	-0.8	-1.2	-1.0	-0.2
Blood clot in the leg (DVT)	0.8	1.0	3.6	0.5	0.5	1.0	1.8	0.2	0.5	-0.3	0.9	0.6	1.1	-1.9
Medication: Paracetamol	0.3	0.5	2.9	0.7	1.7	0.4	-0.4	0.9	0.8	0.2	0.4	0.5	-0.1	-0.5
Headache pain in last month	0.8	1.3	4.1	0.9	1.6	0.4	-1.5	0.2	1.1	0.1	1.0	1.0	1.3	2.0
Medication for cholesterol, blood pressure or diabetes	1.8	2.9	5.6	-2.2	-2.4	-2.0	0.4	-1.6	-1.7	-1.5	-1.9	-2.0	-1.4	-0.8
Glaucoma (self-reported)	1.3	1.6	3.3	-0.5	-0.8	-1.2	1.4	-1.8	-1.5	-0.9	-1.4	-1.4	-1.0	-1.3
Gout (self-reported)	1.1	1.4	7.3	0.2	1.0	-0.3	-2.7	0.9	0.7	2.1	0.4	0.5	0.1	1.1
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	6.6	1.8	1.4	1.6	-0.1	1.6	1.6	0.6	1.6	2.6	1.8	0.2
Medication: Amlodipine	0.8	1.1	2.1	-1.1	-0.9	-1.0	-0.8	0.3	-0.7	1.4	-1.3	-1.5	-1.1	-0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	-0.1	-1.0	-0.5	1.3	-0.6	-0.7	-0.0	-0.7	-0.8	-0.3	-0.0
Birth weight	0.3	0.7	2.4	-0.8	-0.8	-0.4	-0.1	-1.5	-0.1	-1.4	0.7	-0.7	0.9	-0.1
Chronic bronchitis/emphysema (mother)	1.0	1.1	4.4	0.8	1.2	0.6	-0.6	1.4	1.1	2.1	1.1	0.8	0.4	0.3
High blood pressure (siblings)	1.1	1.6	3.9	-1.4	-1.2	-1.4	0.6	-0.3	-1.3	2.0	-1.3	-1.5	-1.4	0.5
Forced vital capacity (FVC), Best measure	0.6	2.4	7.8	-1.9	-0.9	-1.3	1.6	-1.9	-0.4	-2.8	-1.8	-0.8	0.7	-0.9
Body fat percentage	1.7	6.9	16.0	3.9	3.3	3.5	0.3	-0.1	2.2	-1.9	4.0	2.7	1.8	1.4
Leg fat percentage (right)	2.3	8.3	18.6	4.3	3.5	4.0	0.8	0.5	2.6	-1.7	4.2	3.2	2.4	0.8
Arm fat-free mass (right)	1.2	6.4	26.5	1.4	0.6	1.0	3.2	-1.4	-0.1	-5.2	0.7	0.6	2.6	-4.5
Exposure to tobacco smoke outside home	0.6	0.7	1.7	-0.6	-0.2	-1.0	1.0	-1.3	-1.3	-1.0	-0.7	-0.7	-0.7	-0.2
Comparative body size at age 10	0.3	0.7	2.7	1.2	1.6	0.7	-0.2	0.4	0.4	0.9	0.7	0.6	0.8	-0.8
Number of full brothers	2.9	3.6	9.1	3.0	1.7	2.4	-0.9	1.9	1.5	1.3	2.2	2.6	1.6	0.2
Worry too long after embarrassment	0.7	1.2	4.3	0.3	0.8	0.3	-0.5	-1.0	0.5	-2.1	0.8	1.5	2.0	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.8	-0.0	0.6	0.0	-0.7	0.5	0.7	0.6	0.6	0.0	-0.7	-1.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	0.8	0.6	0.3	-0.9	-0.3	0.2	-1.2	0.9	0.3	0.7	-0.5
Number of children fathered	0.8	0.9	1.9	1.1	1.4	1.0	0.6	0.8	0.6	-0.3	0.7	0.8	1.4	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	3.5	1.7	1.6	1.5	-0.3	-0.5	0.8	-1.5	1.9	1.4	1.9	-0.5
Age at first live birth	0.4	0.7	1.7	-1.2	-1.1	-0.9	-0.2	-0.9	-0.6	-0.4	-0.7	-1.0	-0.5	-1.3
Pulse wave peak to peak time	1.0	1.2	2.4	1.5	1.6	1.0	-0.3	-0.9	0.2	-1.2	1.2	1.2	1.2	-0.6
Health satisfaction	0.6	0.8	4.5	1.0	0.6	0.1	0.3	-1.0	-0.2	-2.1	0.7	-0.1	0.4	-1.0
Shortness of breath walking on level ground	1.5	1.8	3.5	1.8	0.5	1.3	-1.5	-0.3	1.3	-0.8	1.7	1.7	1.9	0.8
Qualifications: College or University degree	1.7	5.4	11.2	-2.3	-2.9	-2.5	0.8	1.3	-1.6	2.9	-2.8	-2.6	-3.3	-0.2
Eye problems/disorders: None of the above	1.0	1.2	3.4	1.2	-0.0	0.5	-1.8	1.1	0.5	1.4	1.1	1.0	0.8	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	0.8	0.6	0.7	-0.8	1.2	0.6	0.7	0.7	0.5	-0.4	0.0
Emphysema/chronic bronchitis	1.1	1.2	2.4	1.0	1.5	1.6	-0.3	1.0	1.5	-0.5	1.3	1.0	1.1	0.0
Medication for pain relief, constipation, heartburn	1.2	2.1	7.0	-1.7	-2.6	-1.7	-0.7	-1.4	-1.4	-1.0	-1.4	-1.4	-1.1	0.6
Neck or shoulder pain in last month	0.3	0.4	1.2	1.0	1.1	0.4	-0.5	0.2	0.0	0.2	0.7	0.7	0.2	-0.9
Medication: Blood pressure	1.1	1.9	4.0	2.0	1.7	1.6	0.8	1.0	0.9	1.3	1.3	1.7	1.4	0.9
Angina (self-reported)	0.9	1.2	2.6	1.4	1.6	1.2	0.8	0.1	0.5	-0.5	1.4	1.5	1.2	-0.9
Migraine (self-reported)	1.0	1.3	3.5	-0.1	0.9	0.6	-1.6	0.6	1.6	0.5	1.2	0.7	1.4	1.9
Medication: Ibuprofen	1.1	1.3	4.2	2.1	1.0	1.1	-0.3	1.0	0.6	0.9	0.9	1.3	0.9	1.7
Medication: Allopurinol	0.9	1.2	5.2	0.4	1.1	-0.1	-2.3	1.0	0.5	1.8	0.5	0.4	0.5	1.3
Medication: Omeprazole	1.4	1.7	3.8	1.5	2.0	1.4	-0.5	0.5	1.3	0.5	1.8	1.5	1.5	-0.5
Medication: Seretide 50 evohaler	0.7	0.9	2.5	1.6	0.7	1.2	0.0	0.6	0.7	-0.4	1.5	0.8	1.0	0.0
Mean time to correctly identify matches	1.1	2.1	4.9	0.6	1.4	1.3	1.6	1.6	1.3	1.1	1.1	2.2	2.2	-0.1
Heart disease (mother)	0.5	0.6	2.0	0.5	-0.2	-0.8	-0.2	-1.4	-1.4	-0.9	-0.2	-0.0	-0.0	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.9	0.2	0.4	0.2	-1.4	0.9	0.5	0.7	0.4	-0.1	-0.4	0.0
Whole body fat mass	1.6	6.7	15.2	3.9	3.1	3.3	1.0	-0.4	1.9	-3.0	3.8	2.4	2.2	-0.2
Leg fat mass (right)	2.0	7.7	17.5	4.2	3.2	3.6	1.3	0.3	2.2	-2.9	3.8	2.7	2.7	-0.7
Arm predicted mass (right)	1.2	6.2	25.3	1.4	0.4	0.8	3.1	-1.3	-0.2	-5.0	0.5	0.5	2.6	-4.5
Pulse rate, automated reading	1.2	3.9	8.6	-2.0	-1.7	-2.9	-1.4	-0.9	-2.2	1.2	-2.7	-1.6	-2.6	1.3
Alcohol intake frequency.	0.8	1.9	8.0	0.1	1.0	-0.1	-2.4	0.9	-0.2	2.3	0.1	0.4	-0.4	2.8
Comparative height size at age 10	0.3	1.8	10.6	-0.4	-0.1	-0.2	0.5	-1.3	-0.3	-2.0	-0.0	0.9	1.3	-3.3
Number of full sisters	1.3	1.5	4.5	1.2	1.2	1.1	0.8	2.1	1.1	2.0	0.9	0.9	0.5	0.7
Suffer from ‘nerves’	1.2	1.9	3.1	-1.7	-1.0	-1.8	-1.2	-1.3	-1.2	-1.3	-1.3	-1.5	-1.4	-1.3
Overall health rating	0.4	0.9	2.9	1.4	0.8	0.4	-0.9	0.0	0.3	-1.0	1.7	0.8	0.8	-0.9
Chest pain or discomfort	1.6	2.3	6.2	1.4	1.7	1.7	-0.4	0.4	1.7	-1.4	2.5	1.4	1.9	-0.9
Had major operations	0.9	1.0	2.4	-1.2	-0.5	-0.6	-0.5	-1.6	-0.2	-1.3	-0.4	-1.1	-1.1	1.5
Age at last live birth	1.0	1.4	2.7	-1.5	-1.0	-0.8	-1.6	-1.2	-0.0	-1.3	-0.4	-1.3	-0.9	-1.6
Family relationship satisfaction	1.3	1.6	3.3	-0.8	-1.0	-1.8	-1.3	-0.6	-1.5	-0.3	-1.5	-1.4	-1.1	-1.6
Leg pain on walking	1.2	1.5	3.3	1.8	1.0	1.4	0.6	1.5	1.3	1.0	1.4	1.6	0.4	-0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.2	0.6	0.8	-0.8	0.5	1.2	0.2	0.8	0.3	0.4	0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.4	-0.4	-0.5	-0.7	1.2	-0.6	-0.8	-0.8	-0.9	-1.1	-0.6	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	-0.4	-0.7	-0.8	-1.2	1.1	-0.2	0.8	-1.2	-0.5	-0.9	0.3
Medication: Aspirin	1.8	2.4	4.4	1.7	2.0	2.0	0.1	0.7	1.7	0.6	1.7	2.1	2.0	-0.6
Supplements: Vitamin C	0.7	0.8	3.6	-0.3	0.7	0.4	0.8	0.6	0.4	1.2	0.1	0.8	1.3	-1.9
Knee pain experienced in last month	0.4	0.6	2.3	0.8	1.0	0.4	1.2	-0.6	0.0	-1.5	0.2	0.2	0.5	-0.4
Hypertension (Self-reported)	0.1	0.2	0.7	0.5	0.6	-0.0	-0.4	-0.8	-0.4	0.5	0.3	0.3	0.3	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.2	4.9	11.0	2.8	2.8	2.5	-2.1	1.1	2.0	-0.7	3.3	2.4	2.3	0.4
Illnesses of father: Heart disease	0.2	0.2	0.8	-0.4	-0.9	-0.5	-0.5	-0.5	-0.5	-0.4	-0.7	0.0	0.1	-0.1
Illnesses of siblings: Diabetes	1.8	2.2	6.9	-0.9	-1.6	-1.4	2.6	-1.5	-1.8	-0.6	-1.5	-1.6	-0.9	-0.3
Smoking status: Previous	2.0	3.0	5.8	1.2	1.7	2.4	0.8	2.4	2.3	0.8	2.1	1.7	1.7	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.6	0.2	0.7	0.4	1.2	-0.1	0.5	-1.0	0.1	0.8	1.3	-0.4
Whole body fat-free mass	0.9	5.4	22.7	1.0	0.4	0.5	2.8	-1.5	-0.5	-4.6	0.4	0.0	1.9	-4.8
Leg fat-free mass (right)	0.7	3.8	20.1	1.1	0.2	0.5	2.0	-1.6	-0.4	-4.5	0.5	-0.1	1.6	-3.3
Arm fat percentage (left)	1.6	6.5	16.7	4.1	3.1	3.4	0.0	-0.0	2.1	-1.9	4.0	2.5	1.6	1.1
Average weekly red wine intake	1.1	1.6	9.7	-0.3	0.2	-0.6	2.5	0.6	-0.1	0.2	-0.7	-0.0	0.3	-3.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	4.0	-0.1	0.0	-0.2	2.0	-0.4	-1.0	-0.0	-0.5	0.2	1.5	-0.2
Mood swings	0.8	1.4	5.4	-0.3	0.4	-0.5	-2.1	-2.3	-0.4	-2.0	0.6	-0.1	0.2	0.6
Loneliness, isolation	0.8	1.1	2.7	-1.5	-0.6	-1.0	0.3	-1.5	-0.5	-0.9	-1.3	-0.8	-0.4	-1.6
Long-standing illness, disability or infirmity	1.4	2.1	5.2	1.6	1.6	1.3	0.7	0.1	0.8	-0.7	1.6	1.9	2.3	-1.8
Ever had bowel cancer screening	0.4	0.4	1.5	-0.4	0.2	0.3	-1.2	0.8	1.2	0.7	0.4	-0.2	0.4	0.2
Diabetes diagnosed by doctor	1.1	1.8	6.7	-0.5	-0.0	-0.6	2.5	-1.1	-1.2	-1.2	-1.0	0.2	1.0	-2.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.3	-0.2	-0.0	-0.3	1.1	0.7	0.0	0.6	-0.1	-0.1	-0.3	-0.5
Friendships satisfaction	1.8	2.2	4.9	-0.4	-1.1	-2.0	-1.3	-1.2	-2.0	-0.2	-1.3	-1.4	-2.2	-1.9
Qualifications: nursing, teaching	0.7	1.1	8.1	-0.1	0.3	0.1	1.1	1.5	-0.1	2.8	-0.1	0.3	-0.0	1.0
Commuting to job workplace: Walk	0.8	0.9	2.3	-1.2	-1.5	-0.6	-0.8	0.0	-0.4	0.1	-1.0	-0.9	-1.0	1.4
Eye problems/disorders: Cataract	0.4	0.5	2.6	-0.8	-0.4	0.6	1.6	-0.7	0.2	-0.6	-0.0	-0.2	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	2.3	3.6	7.6	-1.3	-1.3	-2.3	2.1	-2.2	-2.8	-0.8	-1.9	-2.3	-2.2	-0.7
Medication for cholesterol	0.5	0.8	2.8	0.6	-0.2	1.4	-0.7	0.7	1.7	-0.3	1.1	0.5	0.3	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.9	0.2	0.4	0.2	-1.3	0.6	0.5	-0.3	1.0	-0.7	-1.1	-1.4
Back pain experienced in last month	0.5	0.7	2.0	0.3	1.2	0.5	1.4	0.5	0.5	-0.6	0.6	0.6	0.8	-1.3
Mineral and other dietary supplements	0.3	0.4	0.9	-0.1	-0.9	-0.3	-0.6	-0.8	-0.9	-0.9	0.0	-0.6	0.2	0.9
Breast cancer (self-reported)	0.7	0.9	1.9	1.0	1.0	1.1	1.3	1.3	1.4	0.3	0.9	0.5	-0.3	-0.5
Asthma (self-reported)	0.4	0.8	5.1	0.4	-0.3	0.0	0.7	-1.2	-0.4	-2.3	0.2	-0.2	0.2	-1.3
Osteoporosis (self-reported)	0.1	0.1	0.6	-0.3	-0.2	-0.1	-0.7	0.3	-0.0	0.7	0.1	-0.2	-0.1	0.4
Osteoarthritis (self-reported)	1.9	2.4	4.8	1.8	1.7	1.8	1.9	0.6	1.7	-0.3	1.9	2.2	1.4	-0.6
Medication: Aspirin	1.4	1.9	3.4	1.5	1.8	1.7	-0.3	0.6	1.6	0.4	1.6	1.8	1.7	-0.5
Medication: Gliclazide	0.7	0.8	2.1	1.0	1.5	0.7	-0.4	0.8	0.5	0.0	1.0	1.0	1.1	-1.0
Illnesses of father: None of the above (group 1)	1.0	1.2	6.6	0.1	1.0	0.8	-0.3	0.7	1.2	0.8	1.2	-0.5	-0.8	2.6
Smoking status: Current	0.7	1.1	2.0	1.2	1.1	0.8	0.2	0.4	0.9	-0.8	1.1	1.2	1.4	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	8.2	-1.2	-0.0	-0.8	0.0	-2.2	-0.2	-2.9	-0.9	-0.4	1.0	-1.3
Whole body water mass	1.0	5.6	23.3	0.8	0.2	0.3	2.9	-1.7	-0.7	-4.7	0.2	-0.1	1.8	-4.8
Leg predicted mass (right)	0.7	3.9	21.0	1.1	0.3	0.5	2.0	-1.7	-0.4	-4.6	0.5	-0.1	1.6	-3.3
Arm fat mass (left)	1.4	5.9	13.9	3.7	2.8	3.0	1.1	-0.3	1.7	-3.1	3.4	2.1	2.0	-0.6
Number of self-reported non-cancer illnesses	2.2	3.9	7.9	2.3	2.8	2.2	1.6	1.5	2.0	0.7	2.1	2.2	2.2	-0.8
Average weekly champagne plus white wine intake	1.2	1.6	4.8	-0.8	-2.2	-1.8	0.7	-0.1	-1.6	-0.1	-1.6	-1.4	-1.2	-0.4
Miserableness	0.7	1.2	6.2	-0.3	-0.5	-0.7	-2.1	-1.0	-0.3	-0.7	-0.1	-0.3	-0.3	2.5
Guilty feelings	0.4	0.6	1.8	-0.6	-0.6	-0.2	-1.0	-1.0	0.1	-1.1	0.1	0.1	0.4	1.3
Wears glasses or contact lenses	1.7	2.0	4.5	1.5	0.8	1.4	2.1	1.5	1.3	1.6	1.3	1.6	1.3	0.6
Ever taken oral contraceptive pill	0.3	0.3	1.6	-1.3	-0.4	-0.1	0.0	0.3	0.4	0.4	-0.6	-0.7	-0.3	-0.7
Hearing aid user	0.9	1.0	1.8	0.7	1.2	1.1	0.5	1.4	1.3	0.6	0.8	1.1	1.1	-0.8
Mother’s age at death	0.1	0.2	0.6	0.3	0.3	0.3	0.5	0.8	0.3	0.5	-0.2	0.5	0.3	0.2
Financial situation satisfaction	0.7	0.9	2.2	-0.3	-0.9	-1.2	-1.1	-1.4	-1.0	-1.5	-0.6	-0.7	0.1	-0.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.9	0.3	-0.5	-1.4	-1.5	-1.2	-1.7	-0.2	-0.8	-0.4	-0.6	0.3
Commuting to job workplace: Public transport	1.5	1.8	3.9	-1.7	-1.6	-1.6	-0.6	-0.9	-1.3	0.5	-1.6	-1.3	-0.9	2.0
Eye problems/disorders: Glaucoma	0.5	0.5	1.4	-0.5	-0.5	-0.7	0.2	-1.2	-0.6	-0.4	-1.0	-1.1	-0.9	-0.3
Medication: Blood pressure	0.3	0.6	1.3	-0.7	-0.1	-1.1	-1.1	-1.0	-0.8	0.5	-0.7	-0.6	-0.9	-0.6
Pain type(s) experienced in last month: Hip pain	2.4	3.0	5.4	2.1	2.1	2.3	0.1	1.5	1.8	0.3	2.2	2.2	1.8	0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.7	0.2	1.1	0.8	0.1	0.6	1.3	0.4	0.4	1.0	0.2	0.1
High cholesterol (Self-reported)	0.3	0.6	2.3	0.6	1.3	0.1	0.4	1.0	-0.2	1.5	0.0	0.4	0.0	0.9
Medication: Bendroflumethiazide	0.1	0.2	0.7	-0.1	-0.2	-0.4	-0.1	-0.7	-0.8	0.1	-0.4	-0.1	-0.3	-0.3
Medication: Paracetamol	0.3	0.5	1.8	0.8	1.3	0.4	0.5	0.8	0.6	0.1	0.3	0.5	-0.1	-1.0
Medication: Lisinopril	0.5	0.6	1.6	1.0	0.6	0.6	0.4	0.9	1.1	0.2	0.7	0.6	1.3	0.3
Medication: Atorvastatin	1.0	1.3	4.3	0.8	1.6	0.4	-2.1	0.1	0.1	1.1	0.7	0.8	0.8	1.9
Illnesses of father: High blood pressure	0.1	0.2	1.0	0.3	0.4	0.1	0.7	-0.3	0.1	-1.0	-0.0	0.2	0.1	0.0
Alcohol drinker status: Never	0.1	0.1	0.7	0.4	0.4	-0.2	-0.3	-0.3	-0.8	-0.2	-0.1	0.2	-0.4	0.0
Ever smoked	1.0	1.8	4.5	0.6	0.8	1.5	1.3	2.1	1.7	1.6	1.3	1.1	0.8	1.0
Basal metabolic rate	0.9	5.1	21.2	1.6	0.9	1.0	2.6	-1.4	-0.1	-4.6	1.0	0.5	2.1	-4.1
Leg fat percentage (left)	2.0	7.4	16.7	4.1	3.2	3.7	0.7	0.3	2.4	-2.0	3.9	3.0	2.2	1.2
Arm fat-free mass (left)	1.1	5.8	21.8	1.4	0.9	1.0	3.0	-1.2	-0.1	-4.7	0.8	0.5	2.3	-4.6
Number of operations (self-reported)	0.2	0.3	1.2	-0.6	0.5	0.3	0.3	0.4	1.1	-0.3	0.6	-0.3	-0.2	-0.2
Average weekly beer plus cider intake	0.3	0.4	1.5	0.1	-0.4	-0.5	0.2	-0.5	-1.1	0.4	-0.4	-0.3	-0.5	1.2
Irritability	0.4	0.7	3.2	0.5	-0.4	0.2	-1.1	-0.1	0.1	0.6	0.9	0.6	1.0	1.8
Risk taking	0.5	0.7	2.9	0.4	1.1	0.5	-0.7	0.1	0.8	0.5	0.7	0.9	0.8	1.7
Ever had prostate specific antigen (PSA) test	1.2	1.3	8.0	0.6	1.2	0.5	2.8	1.1	0.6	1.2	0.7	0.8	0.6	-0.7
Fractured/broken bones in last 5 years	0.7	0.9	5.2	-0.4	-0.1	0.3	-0.2	1.2	1.1	1.0	0.1	-0.2	-1.0	2.3
Age started oral contraceptive pill	0.7	0.8	1.9	-1.0	-1.4	-1.3	-0.3	-0.7	-1.2	0.1	-1.3	-0.7	-0.5	0.2
Diastolic blood pressure, automated reading	1.2	3.6	12.4	2.3	2.1	1.3	-3.5	-0.2	1.0	-0.4	1.9	1.7	0.9	2.7
Ever depressed for a whole week	0.2	0.3	1.3	1.2	-0.4	-0.2	-0.1	0.3	-0.6	-0.6	-0.3	0.2	0.4	0.5
Unable to work because of sickness or disability	2.2	2.9	6.7	1.8	2.0	1.9	1.3	1.5	1.6	0.9	2.6	2.0	1.6	0.6
Commuting to job workplace: Cycle	1.1	1.3	7.2	-0.9	-0.0	0.1	2.7	-0.2	0.3	0.0	0.3	-1.2	-1.1	-1.8
Myopia	1.4	2.0	7.1	-0.9	-1.6	-1.3	-2.7	-0.1	-1.2	1.3	-0.9	-1.7	-1.5	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.2	-1.0	-1.1	-0.4	-0.3	0.3	0.2	-0.9	-0.6	-0.7	-0.8	-0.2
Cholesterol lowering medication	0.4	0.7	2.1	-0.6	0.6	-0.8	0.3	0.1	-1.3	1.4	-0.8	-0.4	-0.9	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.5	0.8	1.2	0.4	0.0	-0.1	0.5	0.5	0.9	0.4	0.2	-0.8
Pain experienced in last month	0.1	0.1	0.3	-0.5	-0.6	-0.1	-0.0	0.1	0.1	0.3	-0.3	-0.2	-0.5	0.2
Supplements: Calcium	0.2	0.3	1.6	-0.8	-0.3	-0.3	0.3	0.2	0.2	1.3	-0.5	-0.4	0.0	0.2
Basal cell carcinoma (self-reported)	0.8	0.9	4.3	-0.1	0.2	-0.5	-0.8	-1.7	-0.5	-1.3	-0.1	0.1	-0.2	-2.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.8	1.1	1.4	0.8	0.2	-0.1	0.5	-0.1	0.7	1.0	1.2	0.4
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	5.1	-0.0	0.3	0.6	1.8	-0.2	0.3	-0.7	0.5	0.2	0.8	-2.3
Heart disease (siblings)	1.9	2.3	6.4	-1.7	-1.8	-1.5	0.2	-0.4	-1.1	0.9	-1.9	-1.5	-1.4	2.5
Alcohol drinker status: Previous	1.3	1.5	4.8	-0.6	-1.2	-1.4	0.4	-0.7	-1.8	-0.0	-1.3	-2.2	-1.4	-0.5
Pack years of smoking	0.5	0.7	6.1	-0.1	0.5	-0.3	-0.6	0.5	0.1	0.6	-0.2	-0.2	-0.7	2.5
Impedance of whole body	0.7	3.6	16.6	-1.3	0.2	-0.7	-2.7	0.2	0.4	3.2	-0.3	0.6	-1.5	4.1
Leg fat mass (left)	1.9	7.3	16.5	4.1	3.1	3.5	1.3	0.2	2.1	-3.1	3.6	2.6	2.6	-0.5
Arm predicted mass (left)	1.2	5.9	22.5	1.4	0.9	1.0	3.0	-1.2	-0.0	-4.7	0.8	0.7	2.4	-4.6