Best TWAS P=2.27e-23 · Best GWAS P=8.96e-42 conditioned to 1.94e-23
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP11-446E9.1 | 0.07 | 0.00 | lasso | 6 | 0.00 | 6.6e-01 | -6.2 | 7.2 | 8.5e-13 | -0.76 | 0.02 | 0.74 | FALSE |
| 2 | GTEx | Brain Cerebellum | RPS20 | 0.26 | 0.07 | enet | 17 | 0.10 | 5.4e-04 | -8.7 | -7.7 | 1.2e-14 | 0.60 | 0.26 | 0.33 | FALSE |
| 3 | GTEx | Brain Cerebellum | RP11-446E9.1 | 0.15 | 0.05 | lasso | 3 | 0.03 | 3.7e-02 | -6.3 | 6.1 | 8.5e-10 | -0.53 | 0.05 | 0.54 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | RPS20 | 0.41 | 0.05 | lasso | 8 | 0.13 | 3.1e-04 | -6.4 | -6.1 | 7.9e-10 | 0.53 | 0.05 | 0.26 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | LYN | 0.35 | 0.07 | enet | 37 | 0.17 | 4.5e-06 | 10.3 | -5.2 | 1.8e-07 | -0.07 | 0.15 | 0.04 | TRUE |
| 6 | GTEx | Esophagus Muscularis | RPS20 | 0.12 | 0.04 | lasso | 6 | 0.05 | 7.2e-04 | -8.7 | -8.6 | 1.1e-17 | 0.76 | 0.21 | 0.65 | FALSE |
| 7 | GTEx | Muscle Skeletal | RPS20 | 0.07 | 0.09 | lasso | 1 | 0.07 | 1.5e-07 | -6.1 | -6.1 | 7.9e-10 | 0.49 | 0.98 | 0.02 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | RPS20 | 0.18 | 0.03 | enet | 12 | 0.07 | 1.5e-04 | -8.3 | -10.0 | 2.3e-23 | 0.81 | 0.12 | 0.58 | TRUE |
| 9 | GTEx | Stomach | RP11-446E9.1 | 0.12 | 0.08 | lasso | 4 | 0.03 | 1.7e-02 | -5.7 | 5.5 | 3.8e-08 | -0.48 | 0.30 | 0.10 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | RPS20 | 0.24 | 0.20 | lasso | 6 | 0.23 | 3.4e-29 | -7.6 | -6.8 | 7.7e-12 | 0.51 | 1.00 | 0.00 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | RP11-446E9.1 | 0.23 | 0.32 | lasso | 7 | 0.34 | 2.0e-45 | -6.2 | 7.0 | 2.1e-12 | -0.53 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPS20 | 0.04 | 0.02 | blup | 29 | 0.03 | 4.8e-04 | -7.5 | -6.6 | 5.0e-11 | 0.49 | 0.03 | 0.03 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS20 | 0.33 | 0.07 | enet | 8 | 0.07 | 1.7e-08 | -7.6 | -8.8 | 2.0e-18 | 0.49 | 0.96 | 0.03 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS20 | 0.04 | 0.03 | lasso | 3 | 0.04 | 1.3e-04 | -7.6 | -7.5 | 5.5e-14 | 0.58 | 0.15 | 0.05 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | LYN | 0.09 | 0.12 | lasso | 2 | 0.12 | 8.4e-12 | -5.7 | 5.8 | 7.9e-09 | -0.49 | 1.00 | 0.00 | FALSE |