[Hub]/) : Traits : Arm fat-free mass (right) : ← →

chr10:4,236,655-5,844,628

Best TWAS P=2.62e-12 · Best GWAS P=3.21e-12 conditioned to 0.23

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	ROSMAP	Brain Pre-frontal Cortex	AKR1C2	0.56	0.40	enet	28	0.46	1.0e-65	-7.0	-7.0	2.6e-12	0.93	0.00	1.00	TRUE
5	GTEx	Esophagus Muscularis	AKR1C2	0.30	0.21	lasso	2	0.19	8.5e-12	-7.0	-7.0	2.8e-12	1.00	0.00	1.00	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKR1C2	0.12	0.11	lasso	6	0.09	1.6e-10	-7.0	-7.0	2.8e-12	1.00	0.00	1.00	FALSE
4	GTEx	Cells Transformed fibroblasts	AKR1C2	0.28	0.23	lasso	6	0.21	1.9e-15	-7.0	-7.0	3.0e-12	1.00	0.00	1.00	FALSE
8	GTEx	Skin Sun Exposed Lower leg	AKR1C2	0.17	0.18	lasso	2	0.18	4.0e-15	-6.9	-6.9	3.9e-12	1.00	0.00	1.00	FALSE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AKR1C1	0.07	0.04	enet	10	0.02	1.0e-03	-6.8	6.9	7.3e-12	-0.88	0.00	0.99	FALSE
6	GTEx	Heart Atrial Appendage	AKR1C2	0.28	0.37	lasso	3	0.29	1.2e-13	-6.8	-6.8	7.8e-12	0.98	0.00	1.00	FALSE
13	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AKR1C2	0.29	0.21	lasso	1	0.21	4.7e-12	-6.8	-6.8	8.2e-12	0.98	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Thyroid Carcinoma	AKR1C2	0.09	0.08	lasso	3	0.08	7.2e-08	-6.8	-6.7	1.6e-11	0.90	0.00	1.00	FALSE
9	GTEx	Testis	AKR1C2	0.44	0.36	lasso	4	0.36	8.5e-17	-7.0	-6.7	2.2e-11	1.00	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Prostate Adenocarcinoma	AKR1C2	0.39	0.18	enet	14	0.23	2.5e-23	-7.0	-6.6	3.0e-11	0.85	0.00	1.00	FALSE
1	GTEx	Artery Tibial	AKR1C2	0.14	0.10	enet	10	0.15	1.2e-11	-6.8	-6.1	1.3e-09	0.94	0.00	1.00	FALSE
2	GTEx	Brain Cerebellar Hemisphere	AKR1C1	0.46	0.14	lasso	4	0.23	1.4e-06	-3.7	6.0	1.9e-09	-0.85	0.01	0.96	FALSE
7	GTEx	Ovary	AKR1C3	0.35	0.20	lasso	9	0.22	3.9e-06	-7.0	-5.9	4.1e-09	0.91	0.01	0.96	FALSE
3	GTEx	Brain Cortex	AKR1C2	0.49	0.10	lasso	11	0.26	1.1e-07	-7.0	-5.6	1.6e-08	0.85	0.01	0.98	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	AKR1C2	0.09	0.05	blup	62	0.05	3.4e-06	-6.8	-5.4	6.2e-08	0.89	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Soft Tissue Sarcoma	AKR1C2	0.07	0.04	enet	5	0.06	1.1e-04	-3.7	-5.3	1.5e-07	0.74	0.01	0.81	FALSE