Best TWAS P=2.62e-12 · Best GWAS P=3.21e-12 conditioned to 0.23
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | AKR1C2 | 0.14 | 0.10 | enet | 10 | 0.15 | 1.2e-11 | -6.8 | -6.1 | 1.3e-09 | 0.94 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | AKR1C1 | 0.46 | 0.14 | lasso | 4 | 0.23 | 1.4e-06 | -3.7 | 6.0 | 1.9e-09 | -0.85 | 0.01 | 0.96 | FALSE |
| 3 | GTEx | Brain Cortex | AKR1C2 | 0.49 | 0.10 | lasso | 11 | 0.26 | 1.1e-07 | -7.0 | -5.6 | 1.6e-08 | 0.85 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | AKR1C2 | 0.28 | 0.23 | lasso | 6 | 0.21 | 1.9e-15 | -7.0 | -7.0 | 3.0e-12 | 1.00 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Esophagus Muscularis | AKR1C2 | 0.30 | 0.21 | lasso | 2 | 0.19 | 8.5e-12 | -7.0 | -7.0 | 2.8e-12 | 1.00 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | AKR1C2 | 0.28 | 0.37 | lasso | 3 | 0.29 | 1.2e-13 | -6.8 | -6.8 | 7.8e-12 | 0.98 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Ovary | AKR1C3 | 0.35 | 0.20 | lasso | 9 | 0.22 | 3.9e-06 | -7.0 | -5.9 | 4.1e-09 | 0.91 | 0.01 | 0.96 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | AKR1C2 | 0.17 | 0.18 | lasso | 2 | 0.18 | 4.0e-15 | -6.9 | -6.9 | 3.9e-12 | 1.00 | 0.00 | 1.00 | FALSE |
| 9 | GTEx | Testis | AKR1C2 | 0.44 | 0.36 | lasso | 4 | 0.36 | 8.5e-17 | -7.0 | -6.7 | 2.2e-11 | 1.00 | 0.00 | 1.00 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | AKR1C2 | 0.56 | 0.40 | enet | 28 | 0.46 | 1.0e-65 | -7.0 | -7.0 | 2.6e-12 | 0.93 | 0.00 | 1.00 | TRUE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AKR1C1 | 0.07 | 0.04 | enet | 10 | 0.02 | 1.0e-03 | -6.8 | 6.9 | 7.3e-12 | -0.88 | 0.00 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | AKR1C2 | 0.12 | 0.11 | lasso | 6 | 0.09 | 1.6e-10 | -7.0 | -7.0 | 2.8e-12 | 1.00 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | AKR1C2 | 0.29 | 0.21 | lasso | 1 | 0.21 | 4.7e-12 | -6.8 | -6.8 | 8.2e-12 | 0.98 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AKR1C2 | 0.09 | 0.05 | blup | 62 | 0.05 | 3.4e-06 | -6.8 | -5.4 | 6.2e-08 | 0.89 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AKR1C2 | 0.39 | 0.18 | enet | 14 | 0.23 | 2.5e-23 | -7.0 | -6.6 | 3.0e-11 | 0.85 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | AKR1C2 | 0.07 | 0.04 | enet | 5 | 0.06 | 1.1e-04 | -3.7 | -5.3 | 1.5e-07 | 0.74 | 0.01 | 0.81 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | AKR1C2 | 0.09 | 0.08 | lasso | 3 | 0.08 | 7.2e-08 | -6.8 | -6.7 | 1.6e-11 | 0.90 | 0.00 | 1.00 | FALSE |