[Hub]/) : Traits : Arm fat-free mass (right) :

chr12:14,220,891-15,812,575

Best TWAS P=1.01e-12 · Best GWAS P=1.58e-11 conditioned to 0.0215

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C12orf60 0.28 0.25 lasso 4 0.24 2.0e-29 5.5 6.1 8.0e-10 -0.49 0.65 0.35 FALSE
2 GTEx Artery Aorta ARHGDIB 0.10 0.06 enet 10 0.08 5.4e-05 -5.2 5.2 1.8e-07 -0.25 0.70 0.08 FALSE
3 GTEx Artery Tibial WBP11 0.09 0.06 lasso 2 0.06 3.8e-05 -5.9 6.1 1.1e-09 -0.48 0.40 0.57 FALSE
4 GTEx Brain Caudate basal ganglia C12orf60 0.39 0.34 lasso 3 0.32 5.4e-10 5.5 5.6 2.3e-08 -0.37 0.60 0.38 FALSE
5 GTEx Brain Cerebellum C12orf60 0.19 0.17 lasso 3 0.13 1.2e-04 5.5 5.2 1.6e-07 -0.35 0.17 0.12 FALSE
6 GTEx Brain Cortex C12orf60 0.44 0.28 lasso 3 0.29 1.2e-08 5.7 6.1 9.1e-10 -0.42 0.46 0.42 FALSE
7 GTEx Brain Hypothalamus C12orf60 0.28 0.27 lasso 4 0.19 3.8e-05 5.5 5.5 2.9e-08 -0.36 0.21 0.19 FALSE
8 GTEx Brain Nucleus accumbens basal ganglia RP11-174G6.5 0.23 0.13 lasso 4 0.11 8.9e-04 -6.0 6.1 1.4e-09 -0.48 0.17 0.28 FALSE
9 GTEx Brain Putamen basal ganglia C12orf60 0.33 0.32 lasso 3 0.29 1.5e-07 5.7 5.8 8.0e-09 -0.37 0.28 0.35 FALSE
10 GTEx Breast Mammary Tissue (Female) C12orf60 0.19 0.17 lasso 3 0.12 2.6e-04 5.5 5.6 2.3e-08 -0.36 0.13 0.27 FALSE
11 GTEx Cells Transformed fibroblasts C12orf60 0.10 0.10 lasso 2 0.09 1.8e-07 4.8 5.4 6.2e-08 -0.36 0.73 0.27 FALSE
12 GTEx Heart Left Ventricle C12orf60 0.24 0.23 lasso 5 0.26 7.1e-14 5.5 5.8 6.3e-09 -0.42 0.64 0.36 FALSE
13 GTEx Heart Left Ventricle H2AFJ 0.16 0.07 lasso 8 0.05 1.1e-03 -6.3 -6.3 2.9e-10 0.85 0.04 0.96 FALSE
14 GTEx Liver H2AFJ 0.18 0.11 lasso 8 0.04 2.7e-02 -6.3 -5.4 7.7e-08 0.79 0.05 0.70 FALSE
15 GTEx Muscle Skeletal WBP11 0.08 0.08 lasso 5 0.08 2.4e-08 -5.2 5.3 1.4e-07 -0.45 0.65 0.34 FALSE
16 GTEx Muscle Skeletal C12orf60 0.23 0.10 lasso 4 0.12 1.1e-11 5.7 5.3 1.3e-07 -0.26 0.60 0.40 FALSE
17 GTEx Nerve Tibial WBP11 0.11 0.10 lasso 3 0.09 1.0e-06 -5.9 5.2 1.7e-07 -0.42 0.41 0.57 FALSE
18 GTEx Nerve Tibial C12orf60 0.39 0.27 enet 11 0.30 9.6e-22 5.5 5.4 5.1e-08 -0.37 0.65 0.35 FALSE
19 GTEx Skin Not Sun Exposed Suprapubic C12orf60 0.15 0.16 lasso 2 0.13 1.6e-07 5.7 5.6 1.9e-08 -0.36 0.65 0.34 FALSE
20 GTEx Skin Sun Exposed Lower leg C12orf60 0.09 0.06 enet 11 0.05 4.0e-05 5.5 5.8 6.2e-09 -0.44 0.60 0.36 FALSE
21 GTEx Thyroid C12orf60 0.16 0.10 enet 9 0.12 8.1e-10 4.8 6.0 1.6e-09 -0.37 0.81 0.19 FALSE
22 METSIM Adipose C12orf60 0.14 0.10 lasso 4 0.08 1.2e-12 5.5 5.5 4.1e-08 -0.37 0.61 0.39 FALSE
23 METSIM Adipose MGP 0.04 0.04 bslmm 359 0.04 6.2e-07 -4.4 5.3 1.3e-07 -0.37 0.98 0.02 FALSE
24 ROSMAP Brain Pre-frontal Cortex WBP11 0.10 0.05 lasso 4 0.06 1.2e-08 -5.9 7.1 1.0e-12 -0.72 0.08 0.92 TRUE
25 ROSMAP Brain Pre-frontal Cortex C12orf60 0.26 0.29 lasso 5 0.29 1.9e-37 5.7 5.5 3.4e-08 -0.33 0.56 0.44 FALSE
26 YFS Blood H2AFJ 0.05 0.02 bslmm 360 0.03 2.9e-10 -6.3 -6.0 2.4e-09 0.68 0.02 0.98 FALSE
27 The Cancer Genome Atlas Bladder Urothelial Carcinoma C12orf60 0.17 0.03 blup 56 0.07 2.9e-06 4.8 5.5 3.4e-08 -0.63 0.05 0.85 FALSE
28 The Cancer Genome Atlas Breast Invasive Carcinoma C12orf60 0.05 0.04 enet 4 0.04 7.3e-09 5.7 5.2 2.1e-07 -0.29 0.56 0.44 FALSE
29 The Cancer Genome Atlas Breast Invasive Carcinoma ERP27 0.04 0.09 lasso 5 0.09 2.8e-17 -5.4 5.4 8.5e-08 -0.24 0.01 0.99 FALSE
30 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma ERP27 0.09 0.14 lasso 2 0.12 1.7e-06 -5.4 5.4 7.8e-08 -0.24 0.02 0.98 FALSE
31 The Cancer Genome Atlas Esophageal Carcinoma ERP27 0.10 0.12 blup 75 0.08 1.5e-03 -4.9 5.5 3.4e-08 -0.21 0.02 0.87 FALSE
32 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C12orf60 0.10 0.04 enet 7 0.05 2.0e-06 -4.7 5.7 1.5e-08 -0.49 0.27 0.53 FALSE
33 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ERP27 0.10 0.18 lasso 6 0.18 1.2e-19 -5.3 5.1 2.8e-07 -0.26 0.02 0.97 FALSE
34 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma C12orf60 0.12 0.07 enet 8 0.07 5.4e-05 5.7 6.5 9.9e-11 -0.64 0.07 0.83 FALSE
35 The Cancer Genome Atlas Brain Lower Grade Glioma C12orf60 0.14 0.14 lasso 4 0.13 2.2e-14 5.7 6.0 2.0e-09 -0.43 0.55 0.45 FALSE
36 The Cancer Genome Atlas Brain Lower Grade Glioma WBP11 0.03 0.03 blup 57 0.02 2.3e-03 -6.3 6.7 2.1e-11 -0.90 0.01 0.94 FALSE
37 The Cancer Genome Atlas Lung Adenocarcinoma C12orf60 0.07 0.05 enet 7 0.05 1.5e-06 5.7 5.9 4.7e-09 -0.42 0.52 0.47 FALSE
38 The Cancer Genome Atlas Lung Adenocarcinoma ERP27 0.15 0.28 lasso 6 0.28 8.3e-33 -5.4 5.5 3.8e-08 -0.23 0.01 0.99 FALSE
39 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C12orf60 0.05 0.05 lasso 3 0.04 1.1e-05 5.7 6.0 2.4e-09 -0.43 0.51 0.48 FALSE
40 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ERP27 0.17 0.24 enet 13 0.25 6.7e-28 -5.2 5.4 6.1e-08 -0.27 0.02 0.98 FALSE
41 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C12orf60 0.10 0.01 blup 56 0.07 1.6e-05 4.8 6.2 4.2e-10 -0.49 0.08 0.18 FALSE
42 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ERP27 0.14 0.12 lasso 5 0.11 2.9e-05 -5.4 5.5 4.3e-08 -0.23 0.02 0.97 FALSE
43 The Cancer Genome Atlas Prostate Adenocarcinoma C12orf60 0.05 0.03 lasso 1 0.01 1.2e-02 5.7 5.7 1.4e-08 -0.36 0.09 0.15 FALSE
44 The Cancer Genome Atlas Skin Cutaneous Melanoma ERP27 0.13 0.02 blup 74 0.06 1.4e-02 -5.3 5.6 2.4e-08 -0.20 0.02 0.77 FALSE
45 The Cancer Genome Atlas Testicular Germ Cell Tumors ERP27 0.10 0.05 lasso 1 0.08 8.9e-04 -5.4 5.4 5.6e-08 -0.23 0.02 0.96 FALSE
46 The Cancer Genome Atlas Thyroid Carcinoma C12orf60 0.16 0.16 enet 10 0.18 1.3e-17 5.7 6.8 1.4e-11 -0.61 0.57 0.43 FALSE
47 The Cancer Genome Atlas Thyroid Carcinoma ERP27 0.37 0.54 enet 18 0.55 2.3e-63 -5.4 5.3 9.5e-08 -0.23 0.01 0.98 FALSE