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chr12:55,601,472-57,844,049

Best TWAS P=2.54e-15 · Best GWAS P=3.33e-15 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Breast Mammary Tissue (Female)	RPS26	0.20	0.11	lasso	3	0.10	6.6e-04	-5.78	-7.9	2.5e-15	0.84	0.01	0.87	TRUE
1	CommonMind	Brain Pre-frontal Cortex	PRIM1	0.31	0.24	enet	7	0.24	1.1e-28	-7.24	7.4	1.5e-13	-0.01	0.00	1.00	TRUE
16	GTEx	Muscle Skeletal	AC034102.1	0.28	0.31	lasso	4	0.31	2.3e-31	-6.18	6.3	2.2e-10	-0.66	0.99	0.01	TRUE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RPS26	0.22	0.31	lasso	3	0.31	1.6e-35	-6.10	-6.3	2.8e-10	0.65	0.10	0.90	TRUE
25	GTEx	Thyroid	SUOX	0.37	0.40	lasso	7	0.38	5.4e-31	-5.78	6.0	2.6e-09	-0.70	1.00	0.00	TRUE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ESYT1	0.16	0.02	blup	33	0.05	5.5e-03	1.83	-5.2	1.6e-07	0.30	0.01	0.67	TRUE
6	GTEx	Breast Mammary Tissue	RPS26	0.29	0.05	enet	37	0.12	9.4e-07	-6.10	-7.7	1.5e-14	0.63	0.22	0.77	FALSE
45	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RPS26	0.30	0.20	lasso	4	0.24	3.9e-16	-6.10	-6.4	1.4e-10	0.67	0.07	0.93	FALSE
14	GTEx	Muscle Skeletal	RAB5B	0.29	0.32	lasso	4	0.33	1.3e-33	-6.18	6.3	2.2e-10	-0.66	0.99	0.01	FALSE
18	GTEx	Prostate	SUOX	0.22	0.04	enet	11	0.05	2.3e-02	-5.75	6.3	2.2e-10	-0.67	0.10	0.37	FALSE
54	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RPS26	0.46	0.64	lasso	4	0.65	8.5e-30	-6.10	-6.3	2.2e-10	0.64	0.13	0.87	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	RPS26	0.43	0.48	lasso	4	0.47	1.8e-30	-6.10	-6.3	2.6e-10	0.65	0.10	0.90	FALSE
33	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RPS26	0.23	0.40	lasso	2	0.39	1.5e-20	-6.10	-6.3	4.0e-10	0.64	0.11	0.89	FALSE
43	The Cancer Genome Atlas	Lung Adenocarcinoma	RPS26	0.26	0.45	enet	9	0.47	3.6e-61	-6.10	-6.3	4.0e-10	0.66	0.12	0.88	FALSE
35	The Cancer Genome Atlas	Esophageal Carcinoma	RPS26	0.19	0.13	lasso	5	0.11	2.4e-04	-6.10	-6.2	5.0e-10	0.65	0.02	0.95	FALSE
24	GTEx	Testis	SUOX	0.27	0.18	lasso	14	0.18	1.4e-08	-5.78	6.2	5.3e-10	-0.67	0.74	0.25	FALSE
53	The Cancer Genome Atlas	Stomach Adenocarcinoma	RPS26	0.19	0.32	lasso	5	0.34	2.0e-25	-6.03	-6.2	5.9e-10	0.63	0.20	0.80	FALSE
15	GTEx	Muscle Skeletal	SUOX	0.11	0.04	lasso	7	0.04	4.4e-05	-5.78	6.2	6.1e-10	-0.67	0.29	0.63	FALSE
51	The Cancer Genome Atlas	Soft Tissue Sarcoma	RPS26	0.23	0.31	lasso	3	0.30	2.4e-18	-6.10	-6.2	6.4e-10	0.64	0.11	0.89	FALSE
52	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RPS26	0.28	0.15	lasso	2	0.17	3.0e-05	-6.10	-6.2	6.6e-10	0.69	0.02	0.94	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	RPS26	0.33	0.52	enet	9	0.54	5.6e-66	-6.10	-6.2	7.1e-10	0.65	0.11	0.89	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	RPS26	0.30	0.44	enet	10	0.45	5.2e-104	-6.10	-6.1	8.0e-10	0.64	0.10	0.90	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	RPS26	0.31	0.53	enet	8	0.55	1.7e-74	-6.10	-6.1	8.3e-10	0.65	0.15	0.85	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RPS26	0.27	0.38	enet	8	0.40	5.0e-24	-6.10	-6.1	8.8e-10	0.66	0.12	0.88	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RPS26	0.17	0.29	lasso	4	0.29	6.2e-33	-6.03	-6.1	1.0e-09	0.63	0.17	0.83	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RPS26	0.14	0.22	lasso	2	0.23	4.8e-19	-6.03	-6.1	1.1e-09	0.62	0.15	0.85	FALSE
41	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RPS26	0.18	0.31	lasso	2	0.29	3.9e-14	-6.10	-6.1	1.2e-09	0.63	0.12	0.88	FALSE
29	METSIM	Adipose	RPS26	0.30	0.40	lasso	5	0.41	7.2e-66	-6.03	-6.1	1.3e-09	0.62	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Glioblastoma Multiforme	RPS26	0.41	0.38	enet	9	0.39	7.9e-13	-6.03	-6.1	1.3e-09	0.63	0.16	0.84	FALSE
50	The Cancer Genome Atlas	Rectum Adenocarcinoma	RPS26	0.24	0.18	lasso	2	0.20	1.9e-05	-6.10	-6.1	1.3e-09	0.66	0.05	0.57	FALSE
56	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	RPS26	0.17	0.19	lasso	4	0.18	1.3e-05	-6.10	-6.1	1.3e-09	0.67	0.04	0.94	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RPS26	0.48	0.62	lasso	5	0.63	5.9e-99	-6.10	-6.1	1.4e-09	0.64	1.00	0.00	FALSE
10	GTEx	Esophagus Gastroesophageal Junction	SUOX	0.20	0.16	lasso	5	0.19	2.7e-07	-5.75	6.0	1.8e-09	-0.66	0.66	0.27	FALSE
48	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS26	0.47	0.43	lasso	2	0.44	3.2e-19	-5.75	-6.0	2.5e-09	0.67	0.21	0.79	FALSE
47	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RPS26	0.36	0.44	lasso	7	0.42	2.4e-19	-6.03	-6.0	2.6e-09	0.64	0.23	0.77	FALSE
20	GTEx	Skin Sun Exposed Lower leg	SUOX	0.23	0.30	lasso	3	0.29	1.9e-24	-5.78	6.0	2.7e-09	-0.68	1.00	0.00	FALSE
28	METSIM	Adipose	IKZF4	0.04	0.04	enet	3	0.04	1.0e-06	-5.83	-5.9	3.4e-09	0.61	0.99	0.01	FALSE
5	GTEx	Brain Cortex	SUOX	0.16	0.11	lasso	4	0.10	1.1e-03	-5.78	5.9	3.6e-09	-0.68	0.07	0.26	FALSE
13	GTEx	Heart Atrial Appendage	SUOX	0.09	0.10	enet	8	0.09	1.1e-04	-6.10	5.9	3.8e-09	-0.68	0.14	0.63	FALSE
3	GTEx	Artery Tibial	RPS26	0.07	0.02	enet	5	0.01	3.5e-02	-6.10	-5.9	3.9e-09	0.65	0.24	0.16	FALSE
9	GTEx	Colon Sigmoid	RP11-977G19.11	0.22	0.00	enet	33	0.04	1.5e-02	4.51	-5.9	4.7e-09	0.24	0.13	0.07	FALSE
27	GTEx	Whole Blood	RPS26	0.05	0.05	lasso	1	0.05	3.4e-05	-5.75	-5.7	9.1e-09	0.68	0.23	0.68	FALSE
12	GTEx	Esophagus Muscularis	SUOX	0.24	0.19	enet	16	0.15	2.3e-09	-5.78	5.7	1.0e-08	-0.62	0.99	0.01	FALSE
19	GTEx	Skin Not Sun Exposed Suprapubic	SUOX	0.10	0.14	lasso	2	0.12	2.5e-07	-5.78	5.7	1.0e-08	-0.67	0.49	0.44	FALSE
8	GTEx	Colon Sigmoid	SUOX	0.23	0.18	lasso	4	0.15	7.9e-06	-5.78	5.7	1.3e-08	-0.64	0.38	0.57	FALSE
23	GTEx	Stomach	RPS26	0.16	0.08	enet	5	0.05	1.8e-03	-5.78	-5.6	2.4e-08	0.61	0.11	0.46	FALSE
30	YFS	Blood	SUOX	0.11	0.09	bslmm	269	0.09	3.4e-27	-5.75	5.6	2.6e-08	-0.65	1.00	0.00	FALSE
21	GTEx	Spleen	SUOX	0.34	0.31	enet	15	0.28	5.4e-08	-5.78	5.4	5.1e-08	-0.65	0.14	0.76	FALSE
17	GTEx	Nerve Tibial	RPS26	0.12	0.09	enet	7	0.11	3.0e-08	-5.45	-5.4	5.2e-08	0.58	0.96	0.03	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB5B	0.03	0.02	enet	7	0.02	4.3e-03	-6.18	-5.4	5.5e-08	0.57	0.02	0.26	FALSE
22	GTEx	Stomach	SUOX	0.15	0.17	enet	8	0.09	6.7e-05	-5.78	5.4	6.4e-08	-0.65	0.68	0.25	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	RPS26	0.33	0.51	enet	19	0.50	7.3e-56	-6.10	-5.3	1.1e-07	0.64	0.11	0.89	FALSE
26	GTEx	Thyroid	RP11-977G19.11	0.16	0.11	enet	20	0.13	3.5e-10	4.19	-5.3	1.3e-07	0.37	1.00	0.00	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RPS26	0.50	0.45	enet	13	0.52	1.4e-67	-6.03	-5.3	1.3e-07	0.62	0.22	0.78	FALSE
4	GTEx	Brain Cerebellum	SUOX	0.24	0.20	lasso	6	0.20	1.2e-06	-5.78	5.2	2.1e-07	-0.63	0.08	0.86	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	WIBG	0.16	0.02	lasso	5	0.04	1.9e-02	0.26	5.2	2.4e-07	-0.35	0.04	0.24	FALSE