TWAS hub - PRIM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3120	0.058	5.7e-10	0.239	0.083	0.238	0.230	0.237	9.8e-29	2.5e-10	1.1e-28	1.5e-27	1.7e-28
2	GTEx	Esophagus Mucosa	0.1430	0.063	5.6e-03	0.038	NA	0.030	NA	0.034	1.5e-03	NA	3.9e-03	NA	2.3e-03
3	NTR	Blood	0.0866	0.019	0.0e+00	0.112	0.092	0.109	0.109	0.111	4.2e-34	3.4e-28	2.4e-33	3.8e-33	8.4e-34

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Had menopause	18.2	22.7	42.9	-6.5	-4.3	-2.5
Blood Platelet Count	11.1	128.6	376.4	-2.5	-1.8	19.4
Trunk predicted mass	5.4	30.8	70.5	8.4	4.4	1.5
Trunk fat-free mass	5.3	30.7	70.3	8.4	4.4	1.5
Whole body fat-free mass	5.2	29.7	65.4	8.1	4.6	1.4
Whole body water mass	5.2	29.7	65.6	8.1	4.7	1.3
Waist Hip Ratio (WHR)	4.9	21.9	46.2	-6.8	-4.3	-0.9
Ever used hormone-replacement therapy (HRT)	4.9	6.2	13.4	-3.7	-2.2	0.3
Arm fat-free mass (left)	4.9	24.8	56.0	7.5	4.1	1.2
Arm fat-free mass (right)	4.8	24.6	54.6	7.4	4.2	1.4
Arm predicted mass (right)	4.8	24.4	53.0	7.3	4.2	1.6
Medication: Aspirin	4.7	6.1	8.0	-2.0	-2.5	2.8
Leg predicted mass (right)	4.7	24.8	50.7	7.1	4.7	1.4
Arm predicted mass (left)	4.7	23.8	54.0	7.3	4.1	0.8
Leg fat-free mass (right)	4.6	24.6	50.3	7.1	4.7	1.3
Illnesses of siblings	4.5	6.3	8.9	2.6	1.8	-3.0
Basal metabolic rate	4.5	24.9	55.2	7.4	4.3	1.1
Leg fat-free mass (left)	4.3	22.7	48.0	6.9	4.4	1.0
Leg predicted mass (left)	4.3	22.9	48.5	7.0	4.4	1.0
Age at last live birth	4.3	6.2	11.7	3.4	2.6	0.5
Had other major operations	3.9	4.7	5.8	-2.1	-2.0	2.4
Impedance of whole body	3.9	19.7	39.8	-6.3	-4.4	-0.4
Loud music exposure frequency	3.6	3.9	11.2	-0.5	0.6	-3.3
Medication: Aspirin	3.6	4.8	6.4	-1.8	-2.1	2.5
Heart disease (siblings)	3.5	4.3	7.5	-1.9	-1.4	2.7
Impedance of leg (right)	3.2	15.4	27.2	-5.2	-4.3	-1.0
Impedance of leg (left)	3.2	15.4	28.8	-5.4	-4.1	-0.8
Impedance of arm (right)	3.1	14.3	29.6	-5.4	-3.6	-0.5
Headache pain in last month	3.1	5.4	9.2	-1.6	-2.1	3.0
Comparative height size at age 10	3.1	17.0	35.5	6.0	3.4	2.0
Medication: Blood pressure	3.1	5.8	12.2	2.3	0.3	3.5
Alcohol drinker status: Previous	3.1	3.6	7.8	-2.8	-1.7	0.4
Pulse rate	3.0	5.0	9.5	-1.8	-1.5	3.1
Impedance of arm (left)	3.0	14.1	30.4	-5.5	-3.4	-0.5
Chronotype (morning person)	2.9	6.8	10.5	3.2	2.5	2.0
Hand grip strength (left)	2.9	7.8	11.8	3.4	2.8	-1.9
High blood pressure (siblings)	2.9	4.1	7.6	-1.9	-1.1	2.8
Hearing aid user	2.9	3.2	8.3	1.1	0.3	2.9
Diastolic blood pressure, automated reading	2.8	8.8	23.7	1.5	-0.6	4.9
Depressed Affect (Nagel 2018)	2.7	5.8	15.7	-0.5	-1.1	4.0
Hand grip strength (right)	2.7	7.4	10.8	3.3	2.3	-2.4
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	5.6	-2.4	-1.9	-0.9
Pulse wave Arterial Stiffness index	2.7	3.2	8.7	-0.6	-0.6	3.0
Pulse wave peak to peak time	2.7	3.1	7.7	1.1	0.7	-2.8
Miserableness	2.7	4.7	9.7	-1.5	-1.5	3.1
High blood pressure	2.6	7.4	17.2	2.1	0.7	4.2
Hip circumference	2.6	11.2	24.8	5.0	3.0	0.0
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.3	11.1	-1.1	-0.7	3.3
Bipolar Disorder (2018)	2.5	3.9	8.4	-2.9	-1.7	0.6
Allergy or Eczema	2.5	6.5	12.2	2.7	3.5	-0.4
Hypertension (Self-reported)	2.5	7.0	17.0	1.9	0.6	4.1
Myopia	2.5	3.6	5.8	-2.4	-1.9	-1.1
Frequency of depressed mood in last 2 weeks	2.4	3.3	8.0	-1.1	-0.9	2.8
Height	2.3	43.9	107.2	10.4	4.6	1.7
Basal cell carcinoma (self-reported)	2.3	2.7	5.8	-2.4	-1.2	1.0
Cardiovascular Disease	2.2	7.2	20.1	1.2	0.1	4.5
Weight	2.2	10.6	23.9	4.9	2.8	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.2	3.3	9.2	-0.9	-0.0	3.0
Tinnitus: Yes, now most or all of the time	2.2	2.6	3.8	1.9	1.6	1.2
Bipolar Disorder (2011)	2.1	2.1	6.2	0.0	-2.5	-0.1
Hayfever, allergic rhinitis or eczema	2.1	4.6	10.3	1.6	3.2	-0.9
Mood swings	2.1	3.8	6.2	-1.0	-2.0	2.5
Osteoporosis (self-reported)	2.1	2.6	3.4	-1.8	-1.8	-1.1
Ever had prostate specific antigen (PSA) test	2.1	2.4	5.9	0.5	1.1	2.4
Vascular/heart problems diagnosed by doctor	2.1	5.7	14.6	-1.5	-0.5	-3.8
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.3	1.2	0.6	2.3
High blood pressure (mother)	2.0	2.8	6.2	-0.8	-1.2	2.5
Major Depression (MDD)	1.9	2.3	4.4	-1.5	-2.1	0.3
Fasting Glucose	1.9	2.2	5.2	-0.7	-2.3	1.0
Supplements: Zinc	1.9	2.0	4.4	0.6	1.1	2.1
Pain all over the body in last month	1.9	2.1	3.2	1.8	1.7	0.4
Peak expiratory flow (PEF)	1.9	4.4	5.7	2.0	2.4	-1.8
Average weekly spirits intake	1.8	2.2	3.0	1.5	1.2	1.7
Hair/balding pattern: Pattern 2	1.8	2.3	5.9	-0.7	-0.6	2.4
Standing height	1.8	18.3	40.8	6.4	3.1	2.1
Blood clot in the leg (DVT)	1.8	2.3	4.6	-2.1	-1.3	-0.9
Age at first live birth	1.8	3.2	6.7	2.6	1.6	0.7
Blood Red Count	1.7	16.5	42.2	6.5	2.6	0.9
Lung FVC	1.7	8.8	13.2	-2.7	-2.4	-3.6
Medication for cholesterol, blood pressure or diabetes	1.7	2.8	8.3	0.1	0.0	-2.9
Depression (Nagel 2018)	1.6	2.4	6.4	-0.6	-0.7	2.5
Rheumatoid Arthritis	1.6	2.2	4.0	1.6	2.0	0.5
Medication: Metformin	1.6	2.3	3.6	-1.9	-0.7	1.6
Asthma	1.6	3.1	7.6	1.2	2.8	-0.5
Medication: Amlodipine	1.6	2.2	6.1	0.6	-0.5	2.5
Asthma (self-reported)	1.6	3.2	7.4	1.3	2.7	-0.6
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.5	-1.9	-1.3	-1.0
Type 2 Diabetes (T2D) (2012)	1.5	1.7	2.0	-1.4	-1.4	-1.1
Heel T-Score	1.5	12.1	34.7	-0.8	1.0	5.9
Severe depression (siblings)	1.5	1.7	4.8	-0.5	0.1	2.2
Fed-up feelings	1.5	2.7	7.6	-0.3	-0.8	2.8
Supplements: Glucosamine	1.5	1.9	5.7	-0.3	0.0	-2.4
Sitting height	1.5	10.4	21.7	4.7	1.9	2.4
Mouth/teeth dental problems: Loose teeth	1.5	1.7	4.8	0.7	0.2	-2.2
Medication: Allopurinol	1.5	2.0	3.5	-1.9	-1.6	0.2
Medication: Bendroflumethiazide	1.5	2.3	3.4	1.1	1.5	1.8
Ovarian Cancer	1.4	1.9	5.0	0.1	-0.8	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	3.6	1.2	-0.1	-1.9
Illnesses of father: Heart disease	1.4	2.0	5.2	-2.3	-0.8	0.0
Financial situation satisfaction	1.4	1.7	2.6	-1.1	-1.2	-1.6
Medication: Lisinopril	1.4	1.8	5.1	-0.3	0.4	2.2
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.7	-1.9	-0.7	0.8
Number of incorrect matches in round	1.3	2.1	4.8	-0.5	-1.1	-2.2
Lung cancer (father)	1.3	1.5	2.3	-1.0	-1.1	-1.5
Knee pain experienced in last month	1.3	2.1	3.4	-1.1	-1.8	-1.3
Mineral and other dietary supplements	1.3	1.7	4.0	1.0	-0.4	2.0
Diabetes (father)	1.2	1.5	3.2	-0.7	0.9	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.9	0.7	1.3	2.4
Allergy	1.2	2.8	5.7	-1.0	-2.4	1.3
Father’s age at death	1.2	1.6	3.1	1.3	-0.2	-1.8
Health satisfaction	1.2	1.5	4.1	-2.0	-0.7	-0.3
Medication: Blood pressure	1.2	2.1	5.5	0.6	0.6	2.4
Osteoarthritis (self-reported)	1.2	1.6	3.7	-0.4	-0.9	-1.9
Wears glasses or contact lenses	1.2	1.4	1.6	-1.0	-1.3	-1.2
Ever smoked	1.2	2.2	6.1	-0.6	0.3	2.5
Ulcerative Colitis	1.1	1.6	3.3	-1.8	-1.1	0.5
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	4.5	0.6	1.7	2.1
Time employed in main current job	1.1	1.2	2.8	0.1	0.9	-1.7
Medication: Cholesterol lowering	1.1	1.7	4.3	-0.5	-0.8	2.1
Breastfed as a baby	1.1	1.3	2.6	1.6	0.3	1.1
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	2.5	1.6	0.7	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.7	-0.5	-0.4	1.9
Number of children fathered	1.1	1.2	2.1	1.0	0.8	1.5
Shortness of breath walking on level ground	1.1	1.3	1.8	-1.3	-0.9	-1.2
Alcohol intake frequency.	1.1	2.6	7.7	-0.0	0.2	2.8
Body Mass Index (BMI) (2010)	1.0	1.3	3.7	1.9	0.5	0.2
Blood White Count	1.0	7.0	16.6	-4.1	-2.1	0.2
Number of treatments/medications taken	1.0	1.8	3.4	-1.9	-1.1	0.9
Medication for hormone replacement therapy	1.0	1.1	3.1	-1.8	-0.0	-0.4
Medication: Atenolol	1.0	1.2	2.5	0.2	1.1	1.6
Hair/balding pattern: Pattern 3	1.0	1.5	2.6	-0.5	-1.3	-1.6
Prospective memory result	1.0	1.2	3.5	0.1	0.0	1.9
Gout (self-reported)	1.0	1.3	2.7	-1.6	-0.7	-0.9
Migraine (self-reported)	1.0	1.2	3.5	1.9	-0.4	0.0
Pulse rate, automated reading	1.0	3.2	9.3	-0.5	-0.0	3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	1.7	1.3	1.3	-0.2
Illnesses of siblings: Diabetes	1.0	1.3	1.7	-1.1	-1.3	0.9
Loneliness, isolation	1.0	1.3	3.7	0.1	-0.5	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.2	0.8	1.5	0.6
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.2	-0.9	1.0	-1.5
Illnesses of father: High blood pressure	1.0	1.3	2.6	-0.6	-0.9	1.6
Hypothyroidism (self reported)	0.9	2.1	4.4	0.7	1.3	2.1
Neuroticism	0.9	2.1	4.6	-1.2	-0.5	2.1
Townsend deprivation index at recruitment	0.9	1.3	3.7	-0.3	0.4	1.9
Maternal smoking around birth	0.9	1.3	2.2	0.2	1.3	1.5
Chronic bronchitis/emphysema (father)	0.9	1.0	1.8	1.3	1.0	-0.5
Falls in the last year	0.9	1.3	2.8	-1.7	-0.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	2.6	-0.1	-1.6	1.0
Exposure to tobacco smoke at home	0.9	1.0	2.3	0.1	-1.5	0.8
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.7	0.8	1.6	0.4
Wheeze or whistling in the chest in last year	0.9	1.6	3.9	0.1	0.9	2.0
Heart disease (mother)	0.9	1.1	2.7	0.1	0.7	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	2.8	1.2	1.0	1.7
Illnesses of father: None of the above (group 1)	0.9	1.2	1.9	1.3	0.1	-1.4
Alcohol drinker status: Never	0.9	1.1	2.4	1.6	0.3	0.8
Number of operations (self-reported)	0.9	1.3	2.9	-0.9	0.4	1.7
Bipolar Disorder or Schizophrenia	0.8	1.9	5.1	-2.3	-0.7	-0.3
Crohns Disease (2017)	0.8	1.7	2.9	-1.3	-0.5	1.7
Neuroticism (2016)	0.8	1.1	2.5	0.5	0.7	1.6
Sensitivity / hurt feelings	0.8	1.3	2.0	-1.3	-1.4	0.6
Hearing difficulty/problems: Yes	0.8	1.2	3.3	-0.0	1.8	-0.6
Alcohol usually taken with meals	0.8	1.3	2.4	-1.0	0.7	1.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.7	-0.4	-1.6	0.2
Supplements: Vitamin C	0.8	0.9	2.6	-0.4	-0.2	-1.6
Smoking status: Previous	0.8	1.1	2.1	-1.5	-1.1	-0.3
Medication for cholesterol	0.8	1.2	3.7	-0.1	0.1	-1.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.2	-0.9	0.9	-1.8
Guilty feelings	0.8	1.2	3.0	0.4	1.7	0.6
High cholesterol (Self-reported)	0.8	1.3	3.8	-0.5	0.2	1.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.6	-1.6	-0.6	-0.1
Blood Eosinophil Count	0.7	5.7	8.8	1.4	2.5	-3.0
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.3	-1.8	-0.8	-0.1
Angina	0.7	0.9	2.0	-1.4	-0.6	0.5
Stomach or abdominal pain in last month	0.7	0.8	2.0	-0.7	-0.3	1.4
Hearing difficulty/problems with background noise	0.7	1.1	2.9	-1.7	0.3	0.5
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.0	0.7	1.4	0.4
Neuroticism score	0.7	1.5	3.3	-1.0	-0.6	1.8
Depression (self-reported)	0.7	0.8	1.8	0.2	0.8	1.3
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.4	1.5	0.4	-0.1
Comparative body size at age 10	0.7	1.9	3.9	2.0	1.0	0.8
Neck or shoulder pain in last month	0.7	0.9	1.3	-1.1	-0.8	0.9
Medication: Ibuprofen	0.7	0.8	1.6	0.3	-0.8	1.3
Unable to work because of sickness or disability	0.7	0.9	1.7	-1.3	-0.8	0.6
Cholesterol lowering medication	0.7	1.0	1.5	-1.1	-0.4	1.2
Neuroticism (Nagel 2018)	0.6	1.4	4.0	-0.4	-0.1	2.0
Alzheimer’s Disease (including proxy)	0.6	0.9	2.2	-1.5	-0.6	-0.1
Irritable Bowel Disease (IBD)	0.6	1.5	3.3	-1.8	-1.0	0.5
Age at First Birth	0.6	0.8	1.6	1.3	0.6	-0.7
HDL Cholesterol	0.6	1.0	1.1	1.0	1.0	-1.0
Triglycerides	0.6	1.0	1.7	-1.1	-0.3	1.3
BMI	0.6	3.2	5.8	2.4	1.9	-0.5
Ever had hysterectomy (womb removed)	0.6	0.6	0.9	0.8	0.9	0.6
Vitamin and mineral supplements	0.6	0.9	1.7	0.9	1.3	-0.1
Average weekly fortified wine intake	0.6	0.6	1.9	-1.4	-0.1	-0.1
Body mass index (BMI)	0.6	2.6	4.7	2.2	1.4	-1.0
Mouth/teeth dental problems	0.6	0.9	2.7	0.0	1.6	-0.1
Illnesses of mother	0.6	0.8	2.2	0.3	-0.2	-1.5
Exposure to tobacco smoke outside home	0.6	0.8	1.9	-0.6	0.2	1.4
Diabetes diagnosed by doctor	0.6	0.9	1.8	-1.0	0.2	1.3
Qualifications: nursing, teaching	0.6	0.9	2.4	-0.4	-0.2	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	1.3	-1.0	-1.1	-0.2
Number of self-reported non-cancer illnesses	0.6	1.0	2.9	-0.4	0.0	1.7
Ever taken oral contraceptive pill	0.6	0.7	1.5	-0.6	0.4	-1.2
Mother’s age at death	0.6	0.8	1.3	1.1	0.4	-0.9
Medication: Atorvastatin	0.6	0.7	1.9	0.5	0.1	1.4
Schizophrenia vs Biploar Disorder	0.5	0.6	1.7	1.3	0.3	0.2
Alzheimer’s Disease (in father)	0.5	0.6	1.2	-1.1	-0.4	0.6
Schizophrenia (2014)	0.5	1.1	1.6	-1.3	-0.8	-1.1
Smoking Status	0.5	1.2	2.2	-1.5	-1.1	0.5
Respiratory disease	0.5	1.1	2.8	0.4	1.7	-0.6
Pack years adult smoking proportion	0.5	0.7	1.1	0.4	1.0	-0.9
Age when periods started (menarche)	0.5	1.1	2.0	1.4	-1.0	-0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.4	-1.2	-0.5	0.1
Serious illness, injury or assault to yourself	0.5	0.6	1.7	-1.3	-0.1	-0.1
Medication: Levothyroxine sodium	0.5	0.8	1.7	0.6	1.3	0.7
Diabetes (self-reported)	0.5	0.8	1.7	-0.8	-0.2	1.3
Medication: Lansoprazole	0.5	0.5	1.5	0.3	-1.2	0.1
Arm fat mass (right)	0.5	2.0	4.2	2.0	1.0	-1.0
Length of working week for main job	0.5	0.5	1.1	0.2	0.7	1.1
Tense / ‘highly strung’	0.5	0.8	2.0	-1.4	-0.5	-0.5
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.9	0.3	0.9	1.4
Emphysema/chronic bronchitis	0.5	0.5	1.0	-0.2	-0.8	1.0
Medication for pain relief, constipation, heartburn	0.5	0.9	1.5	0.4	1.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.8	0.2	1.3	-0.3
Leg fat mass (right)	0.5	1.8	3.5	1.9	0.8	-1.0
Chest pain or discomfort	0.5	0.7	0.9	-0.9	0.8	0.7
Had major operations	0.5	0.6	0.9	0.7	1.0	-0.7
Average weekly red wine intake	0.5	0.7	1.1	1.1	0.9	-0.3
Eye problems/disorders: Cataract	0.5	0.6	0.8	-0.9	-0.5	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.4	0.5	-0.9	1.2
Arm fat mass (left)	0.5	2.2	5.0	2.2	1.1	-0.6
Commuting to job workplace: Public transport	0.5	0.6	1.9	-0.1	-1.4	0.0
Average weekly beer plus cider intake	0.5	0.7	1.7	-0.6	-0.2	-1.3
Ever depressed for a whole week	0.5	0.6	0.8	-0.8	-0.3	-0.9
Leg fat mass (left)	0.5	1.8	3.5	1.9	1.0	-1.0
Worry (Nagel 2018)	0.4	0.8	2.0	-1.4	0.0	-0.6
Crohns Disease (2012)	0.4	0.6	1.5	-0.4	0.5	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.1	-0.8	0.1	1.1
Relative age voice broke	0.4	0.5	0.9	-0.8	-0.2	-1.0
Multivitamins +/- minerals	0.4	0.6	0.9	-0.8	-0.2	1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.4	-0.0	-1.2	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.8	-0.3	-0.1	1.3
Medication: Ramipril	0.4	0.5	1.6	-0.1	-0.2	1.3
Medication: Simvastatin	0.4	0.5	1.0	-0.7	0.4	1.0
Mouth/teeth dental problems: Dentures	0.4	0.6	1.3	-0.5	-1.1	-0.7
Glaucoma (self-reported)	0.4	0.4	0.8	0.4	0.6	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.7	-0.8	0.2	0.8
Number of full brothers	0.4	0.5	1.1	-0.7	0.1	-1.0
Worry too long after embarrassment	0.4	0.7	1.0	-1.0	-0.8	0.6
Angina (self-reported)	0.4	0.6	1.3	-1.1	-0.4	0.5
Medication: Omeprazole	0.4	0.5	1.1	-1.0	-0.6	0.1
Medication: Seretide 50 evohaler	0.4	0.5	1.1	0.4	0.5	-1.0
Overall health rating	0.4	0.9	2.6	-1.6	-0.4	0.3
Long-standing illness, disability or infirmity	0.4	0.6	1.3	-0.3	0.7	1.1
Ever had bowel cancer screening	0.4	0.5	0.7	-0.8	-0.8	0.5
Breast cancer (self-reported)	0.4	0.4	0.6	0.7	-0.5	0.8
Medication: Gliclazide	0.4	0.5	1.3	-0.5	-0.1	1.1
Smoking status: Current	0.4	0.7	1.6	-0.7	0.2	1.3
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	0.6	1.1	-0.4
Age started oral contraceptive pill	0.4	0.5	0.8	0.8	-0.9	-0.0
Pack years of smoking	0.4	0.6	0.9	0.4	0.8	-1.0
Ulcerative Colitis (UC)	0.3	0.6	1.2	-1.1	-0.8	0.2
Reaction Time	0.3	0.6	1.6	-1.3	-0.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.3	-0.0	-0.1	-1.5
HbA1C	0.3	0.3	0.7	-0.3	-0.8	-0.4
LDL Cholesterol	0.3	0.5	0.7	-0.5	0.8	-0.6
Lupus	0.3	0.4	0.9	-0.9	-0.2	0.5
Systolic Blood Pressure	0.3	1.6	3.4	0.2	-1.2	1.8
Systolic blood pressure, automated reading	0.3	0.8	1.1	1.0	-0.4	1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.0	0.1	1.0	0.0
Trunk fat percentage	0.3	1.2	1.2	-1.1	-1.0	-1.1
Current tobacco smoking	0.3	0.6	1.0	-1.0	-0.1	0.9
Taking other prescription medications	0.3	0.4	1.1	-1.0	0.2	0.3
Past tobacco smoking	0.3	0.6	1.0	1.0	0.3	-0.9
Nervous feelings	0.3	0.6	1.3	-0.7	0.3	-1.1
Worrier / anxious feelings	0.3	0.5	1.4	0.2	-1.2	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.8	-0.3	0.5	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.2	0.8	1.0	-1.1
Birth weight	0.3	0.6	0.7	0.8	0.8	0.7
Body fat percentage	0.3	1.2	1.8	-1.0	-0.8	-1.4
Leg fat percentage (right)	0.3	1.1	2.6	-0.5	-0.6	-1.6
Mean time to correctly identify matches	0.3	0.5	1.2	-1.1	-0.6	0.2
Number of full sisters	0.3	0.3	0.9	0.3	0.9	0.0
Family relationship satisfaction	0.3	0.3	0.9	-0.1	0.3	1.0
Average weekly champagne plus white wine intake	0.3	0.4	0.6	0.8	0.5	0.7
Irritability	0.3	0.5	1.1	-1.1	-0.7	-0.2
Supplements: Calcium	0.3	0.4	0.6	-0.8	0.4	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.9	0.1	-0.2	-1.4
Schizophrenia (2018)	0.2	0.5	0.8	-0.7	0.5	-0.9
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.3	-0.5	0.8
Qualifications: CSEs or equivalent	0.2	0.2	0.5	-0.4	-0.7	-0.0
Waist circumference	0.2	0.8	1.3	1.1	1.0	0.1
Qualifications: None of the above	0.2	0.4	0.8	0.6	0.9	-0.1
Financial difficulties in last 2 years	0.2	0.3	0.7	-0.4	-0.8	-0.1
Heart attack	0.2	0.2	0.5	-0.2	-0.7	0.5
Fluid intelligence score	0.2	0.4	0.9	0.2	0.5	-1.0
Arm fat percentage (right)	0.2	0.7	1.8	-0.4	-0.2	-1.4
Alcohol intake versus 10 years previously	0.2	0.2	0.3	-0.2	0.6	0.6
Number of live births	0.2	0.3	0.9	-0.9	-0.2	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.4	0.4	0.3	-1.2
Happiness	0.2	0.3	0.5	-0.5	-0.3	0.7
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	0.4	-0.2	1.1
Birth weight of first child	0.2	0.4	1.3	0.1	0.2	1.1
Pulse wave reflection index	0.2	0.2	0.3	-0.3	0.5	0.5
Whole body fat mass	0.2	0.9	1.7	1.3	0.4	-0.9
Leg pain on walking	0.2	0.2	0.5	0.3	-0.7	0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.3	-0.3	0.7
Friendships satisfaction	0.2	0.2	0.5	-0.1	0.7	-0.4
Commuting to job workplace: Walk	0.2	0.2	0.5	-0.2	0.7	0.4
Back pain experienced in last month	0.2	0.3	0.5	-0.7	0.2	-0.5
Medication: Paracetamol	0.2	0.3	0.4	0.6	-0.5	0.5
Leg fat percentage (left)	0.2	0.9	2.1	-0.6	-0.5	-1.5
Risk taking	0.2	0.3	0.6	0.7	0.5	0.2
Pain experienced in last month	0.2	0.4	0.8	0.6	0.9	0.2
Alzheimer’s Disease (in mother)	0.1	0.1	0.3	-0.2	0.2	-0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.0	-0.2	-0.5
Mean Putamen Volume	0.1	0.1	0.3	-0.2	0.5	-0.1
Lung FEV1/FVC ratio	0.1	0.6	1.7	0.4	1.3	-0.1
Hair Pigment	0.1	3.5	5.5	2.3	1.8	1.3
Tanning	0.1	1.0	2.1	-0.6	-1.4	-0.7
Relative age of first facial hair	0.1	0.1	0.3	0.5	0.3	-0.1
Diabetes (mother)	0.1	0.2	0.3	-0.4	0.3	-0.5
Trunk fat mass	0.1	0.6	1.2	1.1	0.2	-0.7
Forced vital capacity (FVC)	0.1	0.3	0.6	0.6	-0.3	-0.8
Noisy workplace	0.1	0.1	0.3	-0.5	0.3	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.5	0.7	-0.1
Medication: Paracetamol	0.1	0.1	0.3	0.2	-0.6	0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	0.8	0.3	-1.0
Qualifications: College or University degree	0.1	0.5	0.6	-0.5	-0.7	-0.8
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.5	-0.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.3	0.6	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.6	0.1	-0.3
Arm fat percentage (left)	0.1	0.5	1.4	-0.3	-0.1	-1.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.3	-0.5	-0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	-0.3	0.3	0.4
Commuting to job workplace: Cycle	0.1	0.1	0.3	-0.5	-0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	-0.1	-0.5	0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Medication: Co-codamol	0.0	0.0	0.1	0.2	0.3	0.1
Suffer from ‘nerves’	0.0	0.0	0.0	-0.0	0.2	-0.2
Fractured/broken bones in last 5 years	0.0	0.1	0.1	0.3	0.1	0.3

Hub : Genes

PRIM1

Models

Trait associations