TWAS hub - IKZF4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.128	0.0570	0.00510	0.050	NA	0.040	NA	0.082	2.7e-04	NA	1.0e-03	NA	4.0e-06
2	METSIM	Adipose	0.036	0.0145	0.00064	0.039	0.022	0.040	0.028	0.032	1.4e-06	0.00028	1.0e-06	3.9e-05	1.2e-05
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.071	0.0400	0.00068	0.070	0.062	0.048	NA	0.062	7.5e-05	0.00019	9.3e-04	NA	2.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Allergy	12.6	28.9	74.5	-1.0	-8.6	-3.3
Allergy or Eczema	12.4	32.7	83.7	1.3	9.2	3.6
Hayfever, allergic rhinitis or eczema	11.8	25.7	62.8	0.5	7.9	3.7
Respiratory disease	11.2	24.9	61.3	2.7	7.8	2.5
Hypothyroidism (self reported)	9.8	22.6	56.0	2.4	7.5	2.5
Asthma (self-reported)	9.8	19.4	50.8	1.7	7.1	2.1
Asthma	9.6	18.9	48.5	1.9	7.0	2.2
Hypothyroidism/myxoedema (self-reported)	9.5	18.6	41.5	3.2	6.4	2.0
Qualifications: None of the above	8.1	17.3	39.6	-2.3	-6.3	-2.6
Had other major operations	7.4	9.0	10.6	3.2	2.5	3.2
Medication: Levothyroxine sodium	7.1	12.1	29.7	2.4	5.5	0.8
Hayfever/allergic rhinitis (self-reported)	6.9	9.2	24.2	0.1	4.9	1.8
Reason for reducing amount of alcohol drunk: Health precaution	6.6	7.7	14.7	1.2	3.8	2.7
Neck or shoulder pain in last month	6.6	9.3	19.8	-1.0	-4.4	-2.7
Rheumatoid Arthritis	6.4	8.9	10.7	-2.3	-3.3	-3.2
Qualifications: College or University degree	6.2	19.6	41.1	3.1	6.4	2.8
Mouth/teeth dental problems	5.7	8.8	13.4	1.1	3.7	3.4
Qualifications: A levels/AS levels or equivalent	5.5	12.1	20.5	3.5	4.5	1.9
Fluid intelligence score	5.4	11.3	22.1	2.6	4.7	2.2
Impedance of arm (left)	5.3	24.5	55.1	3.0	7.4	3.0
Medication: Aspirin	5.3	7.0	11.2	-3.4	-1.6	-2.7
Medication: Ventolin 100micrograms inhaler	5.2	6.7	16.1	1.1	4.0	1.7
Pain experienced in last month	5.2	8.6	22.2	0.1	4.7	1.9
Blood Eosinophil Count	4.9	38.1	106.1	1.2	10.3	2.6
Vitamin and mineral supplements	4.9	6.7	8.0	2.3	2.6	2.8
Impedance of arm (right)	4.8	22.5	50.1	3.0	7.1	2.9
Overall health rating	4.8	10.3	15.9	0.8	-4.0	-3.8
Medication: Aspirin	4.7	6.1	10.0	-3.2	-1.6	-2.4
Verbal and Numeric Reasoning (VNR)	4.6	11.2	26.4	1.5	5.1	2.2
Past tobacco smoking	4.6	8.4	16.0	2.6	4.0	1.7
Birth weight	4.6	10.0	18.4	1.4	4.3	3.1
Exposure to tobacco smoke outside home	4.6	6.1	11.8	-1.0	-3.4	-2.3
Mouth/teeth dental problems: Mouth ulcers	4.6	7.3	11.6	-0.6	-3.4	-3.1
Average weekly champagne plus white wine intake	4.5	6.1	14.4	1.0	3.8	1.7
Smoking Status	4.4	10.5	24.9	-1.6	-5.0	-2.0
Impedance of whole body	4.3	21.9	52.7	2.4	7.3	2.7
Lung FEV1/FVC ratio	4.2	21.1	58.4	-1.8	-7.6	-1.3
Average weekly fortified wine intake	4.2	4.9	11.4	0.2	3.4	1.8
Age when periods started (menarche)	4.2	10.0	17.9	0.7	4.2	3.4
Age at first live birth	4.2	7.5	18.8	1.1	4.3	1.6
Smoking status: Previous	3.9	5.8	11.9	-2.2	-3.5	-0.9
Birth weight of first child	3.8	7.0	18.0	1.3	4.2	1.1
Intelligence (Savage-Jansen 2018)	3.7	11.3	26.2	1.8	5.1	2.1
Back pain experienced in last month	3.7	5.4	8.4	0.5	-2.9	-2.7
Arm predicted mass (left)	3.6	18.3	42.9	-2.8	-6.5	-2.0
BMI	3.4	19.6	44.8	-3.2	-6.7	-1.9
Arm fat-free mass (left)	3.4	17.1	39.1	-3.0	-6.2	-1.8
Myopia	3.4	4.9	8.3	2.9	-1.3	-2.2
Townsend deprivation index at recruitment	3.3	4.7	10.6	-0.7	-3.3	-1.7
Headache pain in last month	3.3	5.6	16.5	-0.6	-4.1	0.3
Arm predicted mass (right)	3.3	16.9	37.0	-3.0	-6.1	-2.2
Age at last live birth	3.3	4.8	7.4	0.3	2.7	2.6
Age started oral contraceptive pill	3.3	4.1	11.7	0.6	3.4	0.6
Number of full sisters	3.2	3.9	8.1	-1.4	-2.8	-1.3
Heart disease (siblings)	3.1	3.7	6.1	-0.9	-2.1	-2.5
Trunk fat-free mass	3.0	17.4	38.9	-2.9	-6.2	-2.2
Trunk predicted mass	3.0	17.4	38.6	-3.0	-6.2	-2.2
Arm fat-free mass (right)	3.0	15.5	34.9	-2.7	-5.9	-2.1
Medication: Paracetamol	3.0	4.6	11.9	-0.3	-3.5	-1.4
Ever smoked	3.0	5.2	8.1	-2.4	-2.9	-1.4
Stomach or abdominal pain in last month	2.9	3.6	4.8	-2.2	-2.1	-1.3
Loneliness, isolation	2.9	4.0	6.7	-0.6	-2.6	-2.3
Falls in the last year	2.8	3.7	5.8	1.4	-2.4	-1.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	9.0	25.3	1.0	-5.0	-0.9
Medication: Paracetamol	2.8	4.7	12.6	0.3	-3.6	-1.2
Primary Biliary Cirrhosis	2.7	3.9	9.6	-0.4	-3.1	-1.4
Whole body fat-free mass	2.7	15.5	37.2	-2.5	-6.1	-1.7
Basal metabolic rate	2.7	14.9	37.2	-2.3	-6.1	-1.5
Body mass index (BMI)	2.6	11.0	31.0	-0.9	-5.6	-1.0
Mouth/teeth dental problems: Dentures	2.6	4.4	4.9	-2.2	-2.1	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	9.4	3.1	-0.1	0.9
Hypertension (Self-reported)	2.6	7.3	16.9	1.3	-4.1	-1.8
Whole body water mass	2.6	15.0	36.6	-2.4	-6.0	-1.7
Vascular/heart problems diagnosed by doctor	2.6	7.1	16.2	-0.0	4.0	2.3
High blood pressure	2.5	6.9	16.6	1.1	-4.1	-1.7
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	6.9	0.7	2.6	-1.1
Qualifications: O levels/GCSEs or equivalent	2.5	4.0	8.5	1.7	2.9	0.8
Medication for pain relief, constipation, heartburn	2.5	4.3	8.0	1.6	2.8	1.5
Impedance of leg (right)	2.4	11.4	31.6	0.9	5.6	1.3
Multivitamins +/- minerals	2.4	3.1	5.0	-2.2	-1.4	-1.5
Impedance of leg (left)	2.4	11.7	32.1	1.2	5.7	1.3
Alcohol intake frequency.	2.3	5.4	15.1	0.3	-3.9	-0.9
Smoking status: Current	2.3	3.7	6.4	-1.3	-2.5	-1.7
Average weekly beer plus cider intake	2.3	3.4	5.6	-1.8	-2.4	-1.2
Age at First Birth	2.2	3.2	9.4	0.3	3.1	-0.1
Leg fat-free mass (left)	2.2	11.5	30.1	-1.9	-5.5	-0.9
Number of full brothers	2.2	2.7	3.9	-1.7	-2.0	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.5	5.8	-0.9	-2.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	10.7	1.7	-3.3	-0.5
Angina	2.1	2.8	5.9	-1.5	-0.5	-2.4
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.6	-2.1	-0.7	-1.5
Leg predicted mass (left)	2.1	11.4	29.7	-1.9	-5.4	-0.9
Weight	2.1	10.3	28.7	-1.2	-5.4	-0.8
Mouth/teeth dental problems: Bleeding gums	2.1	2.8	5.1	0.8	-2.2	-1.6
Gout (self-reported)	2.1	2.9	7.0	0.8	-2.6	-1.0
Medication: Seretide 50 evohaler	2.1	2.4	7.1	0.1	2.7	0.2
Leg fat-free mass (right)	2.1	11.1	29.3	-1.8	-5.4	-0.9
Medication: Blood pressure	2.1	3.9	9.6	0.2	-3.1	-1.5
Lung FVC	2.0	10.3	19.2	2.8	-4.4	-2.0
Waist circumference	2.0	7.4	20.3	-0.2	-4.5	-1.3
Alcohol usually taken with meals	2.0	3.3	9.1	0.1	3.0	0.8
Chronic bronchitis/emphysema (mother)	2.0	2.3	4.0	1.3	1.1	2.0
Angina (self-reported)	2.0	2.6	5.8	-1.5	-0.1	-2.4
Knee pain experienced in last month	2.0	3.1	5.7	0.8	-1.7	-2.4
Leg predicted mass (right)	2.0	10.9	28.9	-1.7	-5.4	-0.9
Pulse rate, automated reading	1.9	6.0	15.1	-1.7	-3.9	0.0
Friendships satisfaction	1.9	2.3	3.9	0.9	1.5	2.0
Medication: Atorvastatin	1.9	2.3	3.8	0.6	-2.0	-1.7
Diastolic blood pressure, automated reading	1.9	5.8	16.5	0.3	-4.1	-0.9
Cardiovascular Disease	1.8	5.8	15.5	0.6	-3.9	-1.3
Medication: Cholesterol lowering	1.8	2.8	5.5	-1.4	-1.0	-2.3
Arm fat mass (right)	1.8	7.2	21.4	-0.5	-4.6	-0.3
Forced expiratory volume in 1-second (FEV1)	1.7	5.6	16.5	0.7	-4.1	-0.0
Medication: Allopurinol	1.7	2.2	6.3	-0.0	-2.5	-0.6
Medication: Omeprazole	1.7	2.0	5.8	0.3	-2.4	-0.1
Leg fat mass (right)	1.7	6.5	18.0	-1.1	-4.2	-0.6
Wears glasses or contact lenses	1.7	2.0	4.4	-0.9	0.8	-2.1
Hair/balding pattern: Pattern 3	1.6	2.3	4.3	2.1	0.8	1.4
Breastfed as a baby	1.6	2.0	4.9	0.4	2.2	1.0
Medication for cholesterol	1.6	2.4	5.7	-0.3	2.4	1.2
Leg fat mass (left)	1.6	6.3	18.1	-0.8	-4.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.5	0.7	-2.5	-0.6
Pulse rate	1.5	2.5	6.5	-1.0	-2.5	0.1
Happiness	1.5	1.8	2.5	1.1	1.3	1.6
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	3.8	1.0	1.6	1.9
Mood swings	1.5	2.6	4.0	2.0	-2.0	-0.0
Qualifications: nursing, teaching	1.5	2.4	5.5	1.2	2.3	0.3
Arm fat mass (left)	1.5	6.3	18.6	-0.4	-4.3	-0.2
Lupus	1.4	2.1	4.8	0.8	2.2	-1.1
Blood Red Count	1.4	13.1	27.0	-2.2	-5.2	-2.7
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	3.5	1.9	-0.9	0.5
Hearing difficulty/problems with background noise	1.4	2.2	6.1	0.1	-2.5	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	6.2	2.5	-0.1	0.2
Number of children fathered	1.4	1.6	2.8	-0.2	-1.7	-1.4
Mineral and other dietary supplements	1.4	1.9	2.9	0.3	1.7	1.7
Medication: Gliclazide	1.4	1.6	3.1	-1.8	-1.1	-0.6
Neuroticism (2016)	1.3	1.8	3.3	1.8	0.4	1.4
Current tobacco smoking	1.3	2.2	4.0	-1.0	-2.0	-1.3
Pain all over the body in last month	1.3	1.4	2.7	-1.7	-0.7	0.9
Alcohol intake versus 10 years previously	1.3	1.9	3.9	1.2	-2.0	-0.6
Father’s age at death	1.3	1.8	3.3	-0.1	1.4	1.8
Forced vital capacity (FVC), Best measure	1.3	4.6	11.1	1.5	-3.3	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	2.2	-1.1	1.1	1.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.4	1.0	0.7	1.8
Risk taking	1.3	2.0	4.9	-2.2	-0.7	-0.7
Commuting to job workplace: Cycle	1.3	1.5	4.3	-0.4	2.1	0.3
Alzheimer’s Disease (in mother)	1.2	1.4	2.2	1.4	0.2	1.5
Alzheimer’s Disease (including proxy)	1.2	1.7	4.7	0.6	-0.2	2.2
Fasting Glucose	1.2	1.4	2.3	1.2	-1.5	-0.7
Type 2 Diabetes (T2D) (2012)	1.2	1.3	3.6	1.9	0.6	0.1
Maternal smoking around birth	1.2	1.8	3.9	-0.3	-2.0	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	7.7	-0.6	-0.1	-2.8
Supplements: Glucosamine	1.2	1.6	3.0	-0.9	-0.9	-1.7
Heart attack	1.2	1.6	3.1	-1.8	-0.3	-1.3
Suffer from ‘nerves’	1.2	1.9	1.9	1.4	-1.3	-1.4
Breast cancer (self-reported)	1.2	1.5	2.8	0.5	1.2	1.7
Commuting to job workplace: Public transport	1.2	1.4	2.6	1.1	1.6	0.7
Supplements: Fish oil (including cod liver oil)	1.2	1.5	3.3	-0.1	-1.8	-1.1
High cholesterol (Self-reported)	1.2	2.1	4.1	0.6	-2.0	-1.3
Illnesses of father: High blood pressure	1.2	1.5	3.5	1.9	-0.9	0.3
Worry (Nagel 2018)	1.1	2.2	5.6	2.4	-0.4	-0.9
Reaction Time	1.1	2.1	6.2	-0.1	-2.5	0.4
Number of treatments/medications taken	1.1	2.1	3.5	-0.8	-1.9	-1.5
Systolic blood pressure, automated reading	1.1	3.1	7.5	-0.4	-2.7	-1.2
Chest pain or discomfort	1.1	1.6	2.2	1.2	-1.5	-1.0
Ever taken oral contraceptive pill	1.1	1.2	2.2	0.4	1.5	1.2
Supplements: Calcium	1.1	1.2	2.4	-1.6	-0.4	-1.0
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.7	-1.6	-0.3	-1.2
Ovarian Cancer	1.0	1.3	3.5	0.4	-0.3	1.9
Sensitivity / hurt feelings	1.0	1.8	3.1	0.6	-1.4	-1.8
Qualifications: CSEs or equivalent	1.0	1.4	3.1	-0.9	-1.7	-0.5
Medication: Atenolol	1.0	1.2	3.6	-0.3	-0.3	-1.9
Number of incorrect matches in round	1.0	1.7	2.2	1.5	-1.5	-0.9
Mean time to correctly identify matches	1.0	2.0	4.6	-1.0	-2.1	0.5
Whole body fat mass	1.0	4.4	12.7	-0.6	-3.6	-0.1
Illnesses of father: Heart disease	1.0	1.4	2.7	0.2	1.2	-1.6
Ever had bowel cancer screening	1.0	1.1	1.5	-1.2	-1.0	-0.9
Financial situation satisfaction	1.0	1.2	2.7	-0.6	-1.6	-0.8
Ever had prostate specific antigen (PSA) test	1.0	1.1	2.2	-0.4	-1.0	-1.5
Neuroticism (Nagel 2018)	0.9	2.1	3.5	1.9	-1.1	-1.2
Schizophrenia (2018)	0.9	2.0	4.7	2.2	0.1	-1.1
Relative age voice broke	0.9	1.4	4.3	0.0	2.1	0.2
Medication: Ramipril	0.9	1.1	2.8	-1.7	-0.6	-0.4
Prospective memory result	0.9	1.1	2.1	-0.9	-0.7	-1.4
Medication: Blood pressure	0.9	1.5	2.5	-0.1	-1.6	-1.4
Had major operations	0.9	1.1	1.4	-1.2	-1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.4	-0.4	-1.8	-1.5
Average weekly red wine intake	0.9	1.3	3.0	0.2	1.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.9	-0.9	-1.4	-0.4
Guilty feelings	0.9	1.4	2.0	0.7	-1.4	-1.3
Fractured/broken bones in last 5 years	0.9	1.1	2.2	0.9	-1.5	0.5
Alcohol drinker status: Previous	0.9	1.1	3.0	0.5	-0.1	1.7
Schizophrenia vs Biploar Disorder	0.8	1.1	1.8	-0.9	-1.4	-0.9
Systolic Blood Pressure	0.8	3.9	10.8	0.1	-3.3	-1.0
Neuroticism	0.8	1.9	3.1	1.8	-1.1	-1.2
Relative age of first facial hair	0.8	1.7	4.9	0.3	2.2	0.4
High blood pressure (mother)	0.8	1.1	3.2	-0.2	-0.3	1.8
Arm fat percentage (right)	0.8	3.3	9.3	0.6	-3.0	0.3
Hip circumference	0.8	3.5	10.3	-0.1	-3.2	0.5
Number of live births	0.8	1.2	2.5	-0.7	-0.7	1.6
Tense / ‘highly strung’	0.8	1.4	2.4	0.6	-1.6	-1.2
Peak expiratory flow (PEF)	0.8	1.9	4.1	1.3	-0.3	2.0
Supplements: Vitamin C	0.8	1.0	2.7	-0.2	-0.4	-1.6
Osteoporosis (self-reported)	0.8	1.0	1.8	-0.3	-1.0	-1.3
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.8	1.3	-1.1	-0.0
Number of operations (self-reported)	0.8	1.1	2.6	1.6	0.1	0.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.5	0.3	-1.6	0.6
Bipolar Disorder or Schizophrenia	0.7	1.8	3.8	2.0	0.4	-1.2
Alzheimer’s Disease (in father)	0.7	0.8	1.4	-0.9	-0.2	1.2
Mean Putamen Volume	0.7	0.8	1.8	0.4	1.3	0.8
HDL Cholesterol	0.7	1.1	2.1	-0.7	1.5	0.8
Schizophrenia (2014)	0.7	1.5	2.1	1.5	-0.7	-1.4
Triglycerides	0.7	1.1	1.9	1.2	-1.4	-0.0
Heel T-Score	0.7	5.2	11.3	-0.3	3.4	-2.1
Chronotype (morning person)	0.7	1.6	3.5	-1.9	1.2	0.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.4	0.8	1.2	-0.4
Medication for hormone replacement therapy	0.7	0.8	2.1	-0.1	1.4	0.5
Medication: Co-codamol	0.7	0.8	1.8	0.2	-0.7	-1.3
Hand grip strength (right)	0.7	1.8	4.0	-0.6	1.0	2.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.9	1.4	0.7	0.3
Financial difficulties in last 2 years	0.7	0.9	2.1	0.7	-1.4	-0.5
Noisy workplace	0.7	0.8	2.0	-0.6	-1.4	-0.2
Medication: Lansoprazole	0.7	0.7	2.1	0.3	0.1	1.5
Migraine (self-reported)	0.7	0.8	1.7	-0.6	-1.3	0.5
Leg pain on walking	0.7	0.9	1.6	0.1	-1.3	-1.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.6	0.5	1.3	0.7
Commuting to job workplace: Walk	0.7	0.8	2.0	-1.4	-0.2	-0.4
Illnesses of father: None of the above (group 1)	0.7	0.9	2.6	-0.1	0.4	1.6
Eye problems/disorders: Glaucoma	0.7	0.8	1.1	0.6	1.0	1.0
Basal cell carcinoma (self-reported)	0.7	0.9	2.0	0.3	-0.7	-1.4
Ulcerative Colitis (UC)	0.6	1.1	1.8	0.5	1.2	1.3
Crohns Disease (2012)	0.6	0.9	2.2	0.4	-0.6	-1.5
Blood White Count	0.6	4.3	8.2	-1.6	-2.9	-1.4
Waist Hip Ratio (WHR)	0.6	2.9	5.4	2.3	-0.7	-1.6
Trunk fat mass	0.6	2.6	7.6	-0.4	-2.8	0.2
Forced vital capacity (FVC)	0.6	2.4	5.8	1.2	-2.4	-0.1
Worrier / anxious feelings	0.6	1.2	3.2	1.8	0.1	-0.6
Illnesses of mother	0.6	0.8	1.9	-0.5	-0.3	-1.4
Loud music exposure frequency	0.6	0.7	1.1	1.0	-1.1	0.3
Leg fat percentage (right)	0.6	2.3	6.5	-0.4	-2.5	-0.4
Emphysema/chronic bronchitis	0.6	0.7	1.9	-0.2	1.4	-0.4
Family relationship satisfaction	0.6	0.7	1.3	0.6	-1.1	0.8
Arm fat percentage (left)	0.6	2.3	6.2	0.7	-2.5	0.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.0	0.6	1.0	0.9
Leg fat percentage (left)	0.6	2.2	6.6	-0.2	-2.6	-0.3
Crohns Disease (2017)	0.5	1.1	1.7	1.2	0.0	-1.3
Major Depression (MDD)	0.5	0.6	1.7	1.3	-0.1	-0.4
LDL Cholesterol	0.5	0.8	2.0	0.6	-0.1	-1.4
Hair Pigment	0.5	15.0	25.7	-1.7	-5.1	-4.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	1.1	0.3	-0.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.4	0.5	1.2	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.5	-0.2	-1.0	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	2.9	0.4	0.3	-1.7
Illnesses of siblings	0.5	0.8	1.9	0.2	1.4	0.5
Neuroticism score	0.5	1.0	1.5	1.2	-0.9	-0.9
Length of working week for main job	0.5	0.6	1.1	0.2	-0.8	-1.1
Blood clot in the leg (DVT)	0.5	0.7	1.4	0.7	-1.2	0.5
High blood pressure (siblings)	0.5	0.7	1.8	0.1	-1.4	0.4
Osteoarthritis (self-reported)	0.5	0.6	1.3	-0.3	-1.1	-0.6
Medication: Lisinopril	0.5	0.6	1.3	0.7	-1.2	0.1
Cholesterol lowering medication	0.5	0.7	0.9	0.8	-1.0	-0.8
Depressed Affect (Nagel 2018)	0.4	0.9	2.3	1.5	-0.7	-0.1
Bipolar Disorder (2011)	0.4	0.4	1.1	-0.0	1.0	0.1
Coronary Artery Disease (CAD)	0.4	0.5	1.1	0.2	1.0	0.7
HbA1C	0.4	0.4	0.7	0.6	0.5	0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.4	-0.2	0.0	-1.2
Diabetes (mother)	0.4	0.5	1.6	0.2	-1.2	0.1
Fed-up feelings	0.4	0.8	2.1	0.5	-1.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	0.6	-1.0	0.4
Nervous feelings	0.4	0.8	1.4	1.0	0.1	-1.2
Time employed in main current job	0.4	0.4	0.7	0.6	0.9	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	0.5	-1.1	-0.4
Pulse wave Arterial Stiffness index	0.4	0.4	1.2	0.1	-1.1	-0.3
Hair/balding pattern: Pattern 4	0.4	0.9	2.2	-0.5	1.5	0.6
Medication: Amlodipine	0.4	0.5	1.1	-1.0	-0.6	0.1
Comparative body size at age 10	0.4	1.2	3.4	-1.8	-0.4	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	-0.4	-0.7	-1.0
Eye problems/disorders: Cataract	0.4	0.5	0.7	0.8	0.8	-0.2
Miserableness	0.4	0.8	2.2	1.5	0.3	0.1
Medication: Bendroflumethiazide	0.4	0.6	1.6	-0.2	-1.2	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.7	0.6	-0.8	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	-0.5	-0.9	0.3
Tanning	0.3	3.1	8.1	1.0	0.4	2.8
Average weekly spirits intake	0.3	0.4	1.1	-0.1	0.1	-1.0
Supplements: Zinc	0.3	0.3	0.7	-0.8	-0.4	0.1
Severe depression (siblings)	0.3	0.4	1.0	-0.2	1.0	-0.2
Taking other prescription medications	0.3	0.4	1.0	0.3	1.0	-0.3
Serious illness, injury or assault to yourself	0.3	0.4	0.5	0.6	0.6	-0.7
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	0.3	-0.3	-0.9
Depression (self-reported)	0.3	0.4	0.9	0.4	-0.2	1.0
Lung cancer (father)	0.3	0.4	0.9	-0.2	-0.9	0.6
Pulse wave reflection index	0.3	0.3	0.6	0.8	-0.3	-0.5
Body fat percentage	0.3	1.3	3.6	0.3	-1.9	0.5
Worry too long after embarrassment	0.3	0.5	0.7	0.9	0.6	-0.6
Wheeze or whistling in the chest in last year	0.3	0.5	1.3	-0.2	0.5	-1.1
Pulse wave peak to peak time	0.3	0.4	1.2	-0.1	1.1	0.2
Shortness of breath walking on level ground	0.3	0.4	1.1	0.0	0.3	1.1
Eye problems/disorders: None of the above	0.3	0.3	0.8	0.2	-0.4	0.9
Heart disease (mother)	0.3	0.3	0.6	-0.8	0.3	-0.5
Comparative height size at age 10	0.3	1.5	2.8	-1.3	-1.7	-0.1
Number of self-reported non-cancer illnesses	0.3	0.5	0.6	0.8	0.4	-0.7
Hearing aid user	0.3	0.4	0.8	0.1	0.9	-0.5
Mother’s age at death	0.3	0.3	0.6	0.6	0.1	-0.8
Bipolar Disorder (2018)	0.2	0.3	0.3	0.4	0.5	-0.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	1.1	0.6	0.0
Blood Platelet Count	0.2	2.7	4.9	-1.8	-0.2	-2.2
Height	0.2	3.0	6.4	-2.5	-1.4	-0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.5	-0.0	-0.7
Ever had hysterectomy (womb removed)	0.2	0.2	0.6	0.1	-0.2	-0.8
Pack years adult smoking proportion	0.2	0.2	0.4	-0.4	-0.6	0.4
Trunk fat percentage	0.2	0.8	1.3	0.5	-1.1	0.9
Had menopause	0.2	0.2	0.3	-0.5	0.6	0.4
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.2	-0.0	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	-0.5	-0.6	-0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	0.2	-0.7	0.2
Ever depressed for a whole week	0.2	0.3	0.5	0.7	0.5	-0.2
Depression (Nagel 2018)	0.1	0.1	0.3	0.4	0.0	-0.5
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.3	-0.4	-0.5	-0.2
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.0	-0.5	0.0
Medication: Metformin	0.1	0.1	0.3	-0.4	0.5	0.1
Diabetes (father)	0.1	0.1	0.3	0.2	-0.6	0.1
Sitting height	0.1	0.9	2.0	-0.4	-1.4	-0.8
Diabetes (self-reported)	0.1	0.2	0.2	0.5	0.4	-0.1
Medication: Simvastatin	0.1	0.1	0.2	0.5	0.2	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	-0.5	0.0	-0.6
Glaucoma (self-reported)	0.1	0.1	0.2	0.5	0.4	0.2
Health satisfaction	0.1	0.1	0.3	0.6	-0.0	-0.3
Medication: Ibuprofen	0.1	0.1	0.2	0.5	-0.2	0.2
Illnesses of siblings: Diabetes	0.1	0.2	0.5	-0.3	0.1	-0.7
Long-standing illness, disability or infirmity	0.1	0.2	0.6	-0.0	0.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.3	-0.5	-0.3
Pack years of smoking	0.1	0.1	0.4	-0.2	-0.6	0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.1	0.3	0.0	-0.0
Hand grip strength (left)	0.0	0.1	0.1	-0.3	-0.1	0.3
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.1	-0.3	-0.0
Standing height	0.0	0.4	1.0	-1.0	-0.4	0.1
Diabetes diagnosed by doctor	0.0	0.1	0.1	-0.3	0.1	0.3
Alcohol drinker status: Never	0.0	0.0	0.1	-0.1	-0.3	0.3
Irritability	0.0	0.0	0.1	-0.3	0.0	0.2
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.3	0.1	0.0

Hub : Genes

IKZF4

Models

Trait associations