Hub : Genes

IKZF4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.128 0.0570 0.00510 0.050 NA 0.040 NA 0.082 2.7e-04 NA 1.0e-03 NA 4.0e-06
2 METSIM Adipose 0.036 0.0145 0.00064 0.039 0.022 0.040 0.028 0.032 1.4e-06 0.00028 1.0e-06 3.9e-05 1.2e-05
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.071 0.0400 0.00068 0.070 0.062 0.048 NA 0.062 7.5e-05 0.00019 9.3e-04 NA 2.0e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.2 0.3 0.3 0.4 0.5 -0.5
Bipolar Disorder or Schizophrenia 0.7 1.8 3.8 2.0 0.4 -1.2
Depressed Affect (Nagel 2018) 0.4 0.9 2.3 1.5 -0.7 -0.1
Depression (Nagel 2018) 0.1 0.1 0.3 0.4 0.0 -0.5
Intelligence (Savage-Jansen 2018) 3.7 11.3 26.2 1.8 5.1 2.1
Neuroticism (Nagel 2018) 0.9 2.1 3.5 1.9 -1.1 -1.2
Schizophrenia (2018) 0.9 2.0 4.7 2.2 0.1 -1.1
Schizophrenia vs Biploar Disorder 0.8 1.1 1.8 -0.9 -1.4 -0.9
Worry (Nagel 2018) 1.1 2.2 5.6 2.4 -0.4 -0.9
Alzheimer’s Disease (in mother) 1.2 1.4 2.2 1.4 0.2 1.5
Alzheimer’s Disease (in father) 0.7 0.8 1.4 -0.9 -0.2 1.2
Alzheimer’s Disease (including proxy) 1.2 1.7 4.7 0.6 -0.2 2.2
Crohns Disease (2017) 0.5 1.1 1.7 1.2 0.0 -1.3
Irritable Bowel Disease (IBD) 0.2 0.5 1.1 1.1 0.6 0.0
Ulcerative Colitis (UC) 0.6 1.1 1.8 0.5 1.2 1.3
Major Depression (MDD) 0.5 0.6 1.7 1.3 -0.1 -0.4
Reaction Time 1.1 2.1 6.2 -0.1 -2.5 0.4
Verbal and Numeric Reasoning (VNR) 4.6 11.2 26.4 1.5 5.1 2.2
Breast Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 1.0 1.3 3.5 0.4 -0.3 1.9
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 2.2 3.2 9.4 0.3 3.1 -0.1
Bipolar Disorder (2011) 0.4 0.4 1.1 -0.0 1.0 0.1
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 -0.5 -0.9 0.3
Coronary Artery Disease (CAD) 0.4 0.5 1.1 0.2 1.0 0.7
Crohns Disease (2012) 0.6 0.9 2.2 0.4 -0.6 -1.5
Mean Putamen Volume 0.7 0.8 1.8 0.4 1.3 0.8
Fasting Glucose 1.2 1.4 2.3 1.2 -1.5 -0.7
HbA1C 0.4 0.4 0.7 0.6 0.5 0.8
HDL Cholesterol 0.7 1.1 2.1 -0.7 1.5 0.8
LDL Cholesterol 0.5 0.8 2.0 0.6 -0.1 -1.4
Lupus 1.4 2.1 4.8 0.8 2.2 -1.1
Neuroticism (2016) 1.3 1.8 3.3 1.8 0.4 1.4
Primary Biliary Cirrhosis 2.7 3.9 9.6 -0.4 -3.1 -1.4
Rheumatoid Arthritis 6.4 8.9 10.7 -2.3 -3.3 -3.2
Schizophrenia (2014) 0.7 1.5 2.1 1.5 -0.7 -1.4
Triglycerides 0.7 1.1 1.9 1.2 -1.4 -0.0
Type 2 Diabetes (T2D) (2012) 1.2 1.3 3.6 1.9 0.6 0.1
Ulcerative Colitis 0.0 0.0 0.1 0.3 0.0 -0.0
Blood Eosinophil Count 4.9 38.1 106.1 1.2 10.3 2.6
Blood Platelet Count 0.2 2.7 4.9 -1.8 -0.2 -2.2
Blood Red Count 1.4 13.1 27.0 -2.2 -5.2 -2.7
Blood White Count 0.6 4.3 8.2 -1.6 -2.9 -1.4
Heel T-Score 0.7 5.2 11.3 -0.3 3.4 -2.1
BMI 3.4 19.6 44.8 -3.2 -6.7 -1.9
Height 0.2 3.0 6.4 -2.5 -1.4 -0.9
Waist Hip Ratio (WHR) 0.6 2.9 5.4 2.3 -0.7 -1.6
Systolic Blood Pressure 0.8 3.9 10.8 0.1 -3.3 -1.0
Smoking Status 4.4 10.5 24.9 -1.6 -5.0 -2.0
Allergy or Eczema 12.4 32.7 83.7 1.3 9.2 3.6
Cardiovascular Disease 1.8 5.8 15.5 0.6 -3.9 -1.3
Hypothyroidism (self reported) 9.8 22.6 56.0 2.4 7.5 2.5
Respiratory disease 11.2 24.9 61.3 2.7 7.8 2.5
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.3 -0.4 -0.5 -0.2
Lung FEV1/FVC ratio 4.2 21.1 58.4 -1.8 -7.6 -1.3
Lung FVC 2.0 10.3 19.2 2.8 -4.4 -2.0
Neuroticism 0.8 1.9 3.1 1.8 -1.1 -1.2
Chronotype (morning person) 0.7 1.6 3.5 -1.9 1.2 0.0
Hair Pigment 0.5 15.0 25.7 -1.7 -5.1 -4.0
Tanning 0.3 3.1 8.1 1.0 0.4 2.8
Hand grip strength (left) 0.0 0.1 0.1 -0.3 -0.1 0.3
Number of treatments/medications taken 1.1 2.1 3.5 -0.8 -1.9 -1.5
Average weekly spirits intake 0.3 0.4 1.1 -0.1 0.1 -1.0
Sensitivity / hurt feelings 1.0 1.8 3.1 0.6 -1.4 -1.8
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.1 -0.1 -0.3 -0.0
Hearing difficulty/problems: Yes 0.1 0.1 0.2 -0.0 -0.5 0.0
Relative age of first facial hair 0.8 1.7 4.9 0.3 2.2 0.4
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.4 -0.2 0.0 -1.2
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.6 -0.5 -0.0 -0.7
Ever had hysterectomy (womb removed) 0.2 0.2 0.6 0.1 -0.2 -0.8
Systolic blood pressure, automated reading 1.1 3.1 7.5 -0.4 -2.7 -1.2
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.4 0.8 1.2 -0.4
Angina 2.1 2.8 5.9 -1.5 -0.5 -2.4
Medication for hormone replacement therapy 0.7 0.8 2.1 -0.1 1.4 0.5
Vitamin and mineral supplements 4.9 6.7 8.0 2.3 2.6 2.8
Supplements: Zinc 0.3 0.3 0.7 -0.8 -0.4 0.1
Medication: Co-codamol 0.7 0.8 1.8 0.2 -0.7 -1.3
Medication: Metformin 0.1 0.1 0.3 -0.4 0.5 0.1
Diabetes (father) 0.1 0.1 0.3 0.2 -0.6 0.1
Diabetes (mother) 0.4 0.5 1.6 0.2 -1.2 0.1
Severe depression (siblings) 0.3 0.4 1.0 -0.2 1.0 -0.2
Pack years adult smoking proportion 0.2 0.2 0.4 -0.4 -0.6 0.4
Impedance of leg (right) 2.4 11.4 31.6 0.9 5.6 1.3
Leg fat-free mass (left) 2.2 11.5 30.1 -1.9 -5.5 -0.9
Trunk fat percentage 0.2 0.8 1.3 0.5 -1.1 0.9
Hand grip strength (right) 0.7 1.8 4.0 -0.6 1.0 2.0
Townsend deprivation index at recruitment 3.3 4.7 10.6 -0.7 -3.3 -1.7
Current tobacco smoking 1.3 2.2 4.0 -1.0 -2.0 -1.3
Average weekly fortified wine intake 4.2 4.9 11.4 0.2 3.4 1.8
Maternal smoking around birth 1.2 1.8 3.9 -0.3 -2.0 1.1
Fed-up feelings 0.4 0.8 2.1 0.5 -1.4 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.1 0.6 -1.0 0.4
Relative age voice broke 0.9 1.4 4.3 0.0 2.1 0.2
Taking other prescription medications 0.3 0.4 1.0 0.3 1.0 -0.3
Age when periods started (menarche) 4.2 10.0 17.9 0.7 4.2 3.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.3 1.1 0.3 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 7.7 -0.6 -0.1 -2.8
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 3.5 1.9 -0.9 0.5
Qualifications: CSEs or equivalent 1.0 1.4 3.1 -0.9 -1.7 -0.5
Serious illness, injury or assault to yourself 0.3 0.4 0.5 0.6 0.6 -0.7
High blood pressure 2.5 6.9 16.6 1.1 -4.1 -1.7
Hayfever, allergic rhinitis or eczema 11.8 25.7 62.8 0.5 7.9 3.7
Multivitamins +/- minerals 2.4 3.1 5.0 -2.2 -1.4 -1.5
Stomach or abdominal pain in last month 2.9 3.6 4.8 -2.2 -2.1 -1.3
Supplements: Glucosamine 1.2 1.6 3.0 -0.9 -0.9 -1.7
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 4.6 -2.1 -0.7 -1.5
Medication: Atenolol 1.0 1.2 3.6 -0.3 -0.3 -1.9
Medication: Levothyroxine sodium 7.1 12.1 29.7 2.4 5.5 0.8
Sitting height 0.1 0.9 2.0 -0.4 -1.4 -0.8
Chronic bronchitis/emphysema (father) 0.5 0.6 1.4 0.5 1.2 0.5
High blood pressure (mother) 0.8 1.1 3.2 -0.2 -0.3 1.8
Body mass index (BMI) 2.6 11.0 31.0 -0.9 -5.6 -1.0
Impedance of leg (left) 2.4 11.7 32.1 1.2 5.7 1.3
Leg predicted mass (left) 2.1 11.4 29.7 -1.9 -5.4 -0.9
Trunk fat mass 0.6 2.6 7.6 -0.4 -2.8 0.2
Waist circumference 2.0 7.4 20.3 -0.2 -4.5 -1.3
Number of incorrect matches in round 1.0 1.7 2.2 1.5 -1.5 -0.9
Past tobacco smoking 4.6 8.4 16.0 2.6 4.0 1.7
Alcohol usually taken with meals 2.0 3.3 9.1 0.1 3.0 0.8
Nervous feelings 0.4 0.8 1.4 1.0 0.1 -1.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 1.5 -0.2 -1.0 -1.2
Hearing difficulty/problems with background noise 1.4 2.2 6.1 0.1 -2.5 -0.7
Hair/balding pattern: Pattern 2 0.3 0.3 0.8 0.3 -0.3 -0.9
Had menopause 0.2 0.2 0.3 -0.5 0.6 0.4
Had other major operations 7.4 9.0 10.6 3.2 2.5 3.2
Forced vital capacity (FVC) 0.6 2.4 5.8 1.2 -2.4 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.0 2.9 0.4 0.3 -1.7
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 1.9 1.4 0.7 0.3
Qualifications: None of the above 8.1 17.3 39.6 -2.3 -6.3 -2.6
Financial difficulties in last 2 years 0.7 0.9 2.1 0.7 -1.4 -0.5
Mouth/teeth dental problems 5.7 8.8 13.4 1.1 3.7 3.4
Heart attack 1.2 1.6 3.1 -1.8 -0.3 -1.3
Allergy 12.6 28.9 74.5 -1.0 -8.6 -3.3
Pain all over the body in last month 1.3 1.4 2.7 -1.7 -0.7 0.9
Diabetes (self-reported) 0.1 0.2 0.2 0.5 0.4 -0.1
Hayfever/allergic rhinitis (self-reported) 6.9 9.2 24.2 0.1 4.9 1.8
Medication: Ramipril 0.9 1.1 2.8 -1.7 -0.6 -0.4
Medication: Simvastatin 0.1 0.1 0.2 0.5 0.2 -0.4
Fluid intelligence score 5.4 11.3 22.1 2.6 4.7 2.2
Illnesses of siblings 0.5 0.8 1.9 0.2 1.4 0.5
Neuroticism score 0.5 1.0 1.5 1.2 -0.9 -0.9
Weight 2.1 10.3 28.7 -1.2 -5.4 -0.8
Impedance of arm (right) 4.8 22.5 50.1 3.0 7.1 2.9
Arm fat percentage (right) 0.8 3.3 9.3 0.6 -3.0 0.3
Trunk fat-free mass 3.0 17.4 38.9 -2.9 -6.2 -2.2
Hip circumference 0.8 3.5 10.3 -0.1 -3.2 0.5
Time employed in main current job 0.4 0.4 0.7 0.6 0.9 0.4
Alcohol intake versus 10 years previously 1.3 1.9 3.9 1.2 -2.0 -0.6
Father’s age at death 1.3 1.8 3.3 -0.1 1.4 1.8
Worrier / anxious feelings 0.6 1.2 3.2 1.8 0.1 -0.6
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 6.5 0.7 -2.5 -0.6
Falls in the last year 2.8 3.7 5.8 1.4 -2.4 -1.9
Hair/balding pattern: Pattern 3 1.6 2.3 4.3 2.1 0.8 1.4
Number of live births 0.8 1.2 2.5 -0.7 -0.7 1.6
Forced expiratory volume in 1-second (FEV1) 1.7 5.6 16.5 0.7 -4.1 -0.0
Pulse rate 1.5 2.5 6.5 -1.0 -2.5 0.1
Happiness 1.5 1.8 2.5 1.1 1.3 1.6
Noisy workplace 0.7 0.8 2.0 -0.6 -1.4 -0.2
Qualifications: A levels/AS levels or equivalent 5.5 12.1 20.5 3.5 4.5 1.9
Serious illness, injury or assault of a close relative in last 2 years 2.5 2.9 6.9 0.7 2.6 -1.1
Mouth/teeth dental problems: Dentures 2.6 4.4 4.9 -2.2 -2.1 -2.0
Asthma 9.6 18.9 48.5 1.9 7.0 2.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.2 0.5 -1.1 -0.4
Medication: Cholesterol lowering 1.8 2.8 5.5 -1.4 -1.0 -2.3
Depression (self-reported) 0.3 0.4 0.9 0.4 -0.2 1.0
Medication: Lansoprazole 0.7 0.7 2.1 0.3 0.1 1.5
Prospective memory result 0.9 1.1 2.1 -0.9 -0.7 -1.4
Lung cancer (father) 0.3 0.4 0.9 -0.2 -0.9 0.6
Illnesses of mother 0.6 0.8 1.9 -0.5 -0.3 -1.4
Forced expiratory volume in 1-second (FEV1), Best measure 2.8 9.0 25.3 1.0 -5.0 -0.9
Pulse wave Arterial Stiffness index 0.4 0.4 1.2 0.1 -1.1 -0.3
Impedance of arm (left) 5.3 24.5 55.1 3.0 7.4 3.0
Arm fat mass (right) 1.8 7.2 21.4 -0.5 -4.6 -0.3
Trunk predicted mass 3.0 17.4 38.6 -3.0 -6.2 -2.2
Standing height 0.0 0.4 1.0 -1.0 -0.4 0.1
Length of working week for main job 0.5 0.6 1.1 0.2 -0.8 -1.1
Exposure to tobacco smoke at home 0.2 0.2 0.6 0.2 -0.0 0.8
Breastfed as a baby 1.6 2.0 4.9 0.4 2.2 1.0
Tense / ‘highly strung’ 0.8 1.4 2.4 0.6 -1.6 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 6.2 2.5 -0.1 0.2
Hair/balding pattern: Pattern 4 0.4 0.9 2.2 -0.5 1.5 0.6
Birth weight of first child 3.8 7.0 18.0 1.3 4.2 1.1
Peak expiratory flow (PEF) 0.8 1.9 4.1 1.3 -0.3 2.0
Pulse wave reflection index 0.3 0.3 0.6 0.8 -0.3 -0.5
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.3 -0.5 0.0 -0.6
Loud music exposure frequency 0.6 0.7 1.1 1.0 -1.1 0.3
Qualifications: O levels/GCSEs or equivalent 2.5 4.0 8.5 1.7 2.9 0.8
Mouth/teeth dental problems: Bleeding gums 2.1 2.8 5.1 0.8 -2.2 -1.6
Blood clot in the leg (DVT) 0.5 0.7 1.4 0.7 -1.2 0.5
Medication: Paracetamol 2.8 4.7 12.6 0.3 -3.6 -1.2
Headache pain in last month 3.3 5.6 16.5 -0.6 -4.1 0.3
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 3.8 1.0 1.6 1.9
Glaucoma (self-reported) 0.1 0.1 0.2 0.5 0.4 0.2
Gout (self-reported) 2.1 2.9 7.0 0.8 -2.6 -1.0
Hypothyroidism/myxoedema (self-reported) 9.5 18.6 41.5 3.2 6.4 2.0
Medication: Amlodipine 0.4 0.5 1.1 -1.0 -0.6 0.1
Medication: Ventolin 100micrograms inhaler 5.2 6.7 16.1 1.1 4.0 1.7
Birth weight 4.6 10.0 18.4 1.4 4.3 3.1
Chronic bronchitis/emphysema (mother) 2.0 2.3 4.0 1.3 1.1 2.0
High blood pressure (siblings) 0.5 0.7 1.8 0.1 -1.4 0.4
Forced vital capacity (FVC), Best measure 1.3 4.6 11.1 1.5 -3.3 -0.7
Body fat percentage 0.3 1.3 3.6 0.3 -1.9 0.5
Leg fat percentage (right) 0.6 2.3 6.5 -0.4 -2.5 -0.4
Arm fat-free mass (right) 3.0 15.5 34.9 -2.7 -5.9 -2.1
Exposure to tobacco smoke outside home 4.6 6.1 11.8 -1.0 -3.4 -2.3
Comparative body size at age 10 0.4 1.2 3.4 -1.8 -0.4 -0.4
Number of full brothers 2.2 2.7 3.9 -1.7 -2.0 -1.2
Worry too long after embarrassment 0.3 0.5 0.7 0.9 0.6 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.4 9.4 3.1 -0.1 0.9
Wheeze or whistling in the chest in last year 0.3 0.5 1.3 -0.2 0.5 -1.1
Number of children fathered 1.4 1.6 2.8 -0.2 -1.7 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 6.6 7.7 14.7 1.2 3.8 2.7
Age at first live birth 4.2 7.5 18.8 1.1 4.3 1.6
Pulse wave peak to peak time 0.3 0.4 1.2 -0.1 1.1 0.2
Health satisfaction 0.1 0.1 0.3 0.6 -0.0 -0.3
Shortness of breath walking on level ground 0.3 0.4 1.1 0.0 0.3 1.1
Qualifications: College or University degree 6.2 19.6 41.1 3.1 6.4 2.8
Eye problems/disorders: None of the above 0.3 0.3 0.8 0.2 -0.4 0.9
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.9 -0.4 -0.7 -1.0
Emphysema/chronic bronchitis 0.6 0.7 1.9 -0.2 1.4 -0.4
Medication for pain relief, constipation, heartburn 2.5 4.3 8.0 1.6 2.8 1.5
Neck or shoulder pain in last month 6.6 9.3 19.8 -1.0 -4.4 -2.7
Medication: Blood pressure 0.9 1.5 2.5 -0.1 -1.6 -1.4
Angina (self-reported) 2.0 2.6 5.8 -1.5 -0.1 -2.4
Migraine (self-reported) 0.7 0.8 1.7 -0.6 -1.3 0.5
Medication: Ibuprofen 0.1 0.1 0.2 0.5 -0.2 0.2
Medication: Allopurinol 1.7 2.2 6.3 -0.0 -2.5 -0.6
Medication: Omeprazole 1.7 2.0 5.8 0.3 -2.4 -0.1
Medication: Seretide 50 evohaler 2.1 2.4 7.1 0.1 2.7 0.2
Mean time to correctly identify matches 1.0 2.0 4.6 -1.0 -2.1 0.5
Heart disease (mother) 0.3 0.3 0.6 -0.8 0.3 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.6 2.2 -1.1 1.1 1.5
Whole body fat mass 1.0 4.4 12.7 -0.6 -3.6 -0.1
Leg fat mass (right) 1.7 6.5 18.0 -1.1 -4.2 -0.6
Arm predicted mass (right) 3.3 16.9 37.0 -3.0 -6.1 -2.2
Pulse rate, automated reading 1.9 6.0 15.1 -1.7 -3.9 0.0
Alcohol intake frequency. 2.3 5.4 15.1 0.3 -3.9 -0.9
Comparative height size at age 10 0.3 1.5 2.8 -1.3 -1.7 -0.1
Number of full sisters 3.2 3.9 8.1 -1.4 -2.8 -1.3
Suffer from ‘nerves’ 1.2 1.9 1.9 1.4 -1.3 -1.4
Overall health rating 4.8 10.3 15.9 0.8 -4.0 -3.8
Chest pain or discomfort 1.1 1.6 2.2 1.2 -1.5 -1.0
Had major operations 0.9 1.1 1.4 -1.2 -1.2 -0.7
Age at last live birth 3.3 4.8 7.4 0.3 2.7 2.6
Family relationship satisfaction 0.6 0.7 1.3 0.6 -1.1 0.8
Leg pain on walking 0.7 0.9 1.6 0.1 -1.3 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.3 -0.5 -0.6 -0.0
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.5 0.2 -0.7 0.2
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.4 1.0 0.7 1.8
Medication: Aspirin 5.3 7.0 11.2 -3.4 -1.6 -2.7
Supplements: Vitamin C 0.8 1.0 2.7 -0.2 -0.4 -1.6
Knee pain experienced in last month 2.0 3.1 5.7 0.8 -1.7 -2.4
Hypertension (Self-reported) 2.6 7.3 16.9 1.3 -4.1 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.5 5.8 -0.9 -2.4 -1.0
Illnesses of father: Heart disease 1.0 1.4 2.7 0.2 1.2 -1.6
Illnesses of siblings: Diabetes 0.1 0.2 0.5 -0.3 0.1 -0.7
Smoking status: Previous 3.9 5.8 11.9 -2.2 -3.5 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 3.4 -0.4 -1.8 -1.5
Whole body fat-free mass 2.7 15.5 37.2 -2.5 -6.1 -1.7
Leg fat-free mass (right) 2.1 11.1 29.3 -1.8 -5.4 -0.9
Arm fat percentage (left) 0.6 2.3 6.2 0.7 -2.5 0.5
Average weekly red wine intake 0.9 1.3 3.0 0.2 1.7 1.0
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.6 0.5 1.3 0.7
Mood swings 1.5 2.6 4.0 2.0 -2.0 -0.0
Loneliness, isolation 2.9 4.0 6.7 -0.6 -2.6 -2.3
Long-standing illness, disability or infirmity 0.1 0.2 0.6 -0.0 0.1 -0.8
Ever had bowel cancer screening 1.0 1.1 1.5 -1.2 -1.0 -0.9
Diabetes diagnosed by doctor 0.0 0.1 0.1 -0.3 0.1 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.9 -0.9 -1.4 -0.4
Friendships satisfaction 1.9 2.3 3.9 0.9 1.5 2.0
Qualifications: nursing, teaching 1.5 2.4 5.5 1.2 2.3 0.3
Commuting to job workplace: Walk 0.7 0.8 2.0 -1.4 -0.2 -0.4
Eye problems/disorders: Cataract 0.4 0.5 0.7 0.8 0.8 -0.2
Mouth/teeth dental problems: Mouth ulcers 4.6 7.3 11.6 -0.6 -3.4 -3.1
Medication for cholesterol 1.6 2.4 5.7 -0.3 2.4 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.2 -0.3 -0.5 -0.3
Back pain experienced in last month 3.7 5.4 8.4 0.5 -2.9 -2.7
Mineral and other dietary supplements 1.4 1.9 2.9 0.3 1.7 1.7
Breast cancer (self-reported) 1.2 1.5 2.8 0.5 1.2 1.7
Asthma (self-reported) 9.8 19.4 50.8 1.7 7.1 2.1
Osteoporosis (self-reported) 0.8 1.0 1.8 -0.3 -1.0 -1.3
Osteoarthritis (self-reported) 0.5 0.6 1.3 -0.3 -1.1 -0.6
Medication: Aspirin 4.7 6.1 10.0 -3.2 -1.6 -2.4
Medication: Gliclazide 1.4 1.6 3.1 -1.8 -1.1 -0.6
Illnesses of father: None of the above (group 1) 0.7 0.9 2.6 -0.1 0.4 1.6
Smoking status: Current 2.3 3.7 6.4 -1.3 -2.5 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.2 4.6 10.7 1.7 -3.3 -0.5
Whole body water mass 2.6 15.0 36.6 -2.4 -6.0 -1.7
Leg predicted mass (right) 2.0 10.9 28.9 -1.7 -5.4 -0.9
Arm fat mass (left) 1.5 6.3 18.6 -0.4 -4.3 -0.2
Number of self-reported non-cancer illnesses 0.3 0.5 0.6 0.8 0.4 -0.7
Average weekly champagne plus white wine intake 4.5 6.1 14.4 1.0 3.8 1.7
Miserableness 0.4 0.8 2.2 1.5 0.3 0.1
Guilty feelings 0.9 1.4 2.0 0.7 -1.4 -1.3
Wears glasses or contact lenses 1.7 2.0 4.4 -0.9 0.8 -2.1
Ever taken oral contraceptive pill 1.1 1.2 2.2 0.4 1.5 1.2
Hearing aid user 0.3 0.4 0.8 0.1 0.9 -0.5
Mother’s age at death 0.3 0.3 0.6 0.6 0.1 -0.8
Financial situation satisfaction 1.0 1.2 2.7 -0.6 -1.6 -0.8
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.0 0.6 1.0 0.9
Commuting to job workplace: Public transport 1.2 1.4 2.6 1.1 1.6 0.7
Eye problems/disorders: Glaucoma 0.7 0.8 1.1 0.6 1.0 1.0
Medication: Blood pressure 2.1 3.9 9.6 0.2 -3.1 -1.5
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.8 1.3 -1.1 -0.0
Supplements: Fish oil (including cod liver oil) 1.2 1.5 3.3 -0.1 -1.8 -1.1
High cholesterol (Self-reported) 1.2 2.1 4.1 0.6 -2.0 -1.3
Medication: Bendroflumethiazide 0.4 0.6 1.6 -0.2 -1.2 0.5
Medication: Paracetamol 3.0 4.6 11.9 -0.3 -3.5 -1.4
Medication: Lisinopril 0.5 0.6 1.3 0.7 -1.2 0.1
Medication: Atorvastatin 1.9 2.3 3.8 0.6 -2.0 -1.7
Illnesses of father: High blood pressure 1.2 1.5 3.5 1.9 -0.9 0.3
Alcohol drinker status: Never 0.0 0.0 0.1 -0.1 -0.3 0.3
Ever smoked 3.0 5.2 8.1 -2.4 -2.9 -1.4
Basal metabolic rate 2.7 14.9 37.2 -2.3 -6.1 -1.5
Leg fat percentage (left) 0.6 2.2 6.6 -0.2 -2.6 -0.3
Arm fat-free mass (left) 3.4 17.1 39.1 -3.0 -6.2 -1.8
Number of operations (self-reported) 0.8 1.1 2.6 1.6 0.1 0.9
Average weekly beer plus cider intake 2.3 3.4 5.6 -1.8 -2.4 -1.2
Irritability 0.0 0.0 0.1 -0.3 0.0 0.2
Risk taking 1.3 2.0 4.9 -2.2 -0.7 -0.7
Ever had prostate specific antigen (PSA) test 1.0 1.1 2.2 -0.4 -1.0 -1.5
Fractured/broken bones in last 5 years 0.9 1.1 2.2 0.9 -1.5 0.5
Age started oral contraceptive pill 3.3 4.1 11.7 0.6 3.4 0.6
Diastolic blood pressure, automated reading 1.9 5.8 16.5 0.3 -4.1 -0.9
Ever depressed for a whole week 0.2 0.3 0.5 0.7 0.5 -0.2
Unable to work because of sickness or disability 0.0 0.0 0.1 -0.3 0.1 0.0
Commuting to job workplace: Cycle 1.3 1.5 4.3 -0.4 2.1 0.3
Myopia 3.4 4.9 8.3 2.9 -1.3 -2.2
Vascular/heart problems diagnosed by doctor 2.6 7.1 16.2 -0.0 4.0 2.3
Cholesterol lowering medication 0.5 0.7 0.9 0.8 -1.0 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.5 0.3 -1.6 0.6
Pain experienced in last month 5.2 8.6 22.2 0.1 4.7 1.9
Supplements: Calcium 1.1 1.2 2.4 -1.6 -0.4 -1.0
Basal cell carcinoma (self-reported) 0.7 0.9 2.0 0.3 -0.7 -1.4
Heart attack/myocardial infarction (self-reported) 1.1 1.4 2.7 -1.6 -0.3 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 0.7 0.6 -0.8 0.8
Heart disease (siblings) 3.1 3.7 6.1 -0.9 -2.1 -2.5
Alcohol drinker status: Previous 0.9 1.1 3.0 0.5 -0.1 1.7
Pack years of smoking 0.1 0.1 0.4 -0.2 -0.6 0.1
Impedance of whole body 4.3 21.9 52.7 2.4 7.3 2.7
Leg fat mass (left) 1.6 6.3 18.1 -0.8 -4.2 -0.5
Arm predicted mass (left) 3.6 18.3 42.9 -2.8 -6.5 -2.0