[Hub]/) : Traits : Arm fat-free mass (right) :

chr16:71,070,698-72,569,466

Best TWAS P=9.41e-10 · Best GWAS P=4.28e-11 conditioned to 6.2e-05

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PHLPP2 0.04 0.01 bslmm 456 0.02 4.7e-04 -4.6 -5.7 1.4e-08 0.57 0.41 0.50 FALSE
2 GTEx Adrenal Gland AP1G1 0.22 0.06 enet 25 0.14 8.0e-06 -5.5 -5.2 1.8e-07 0.58 0.12 0.86 FALSE
3 GTEx Heart Left Ventricle PHLPP2 0.14 0.10 lasso 8 0.07 1.8e-04 5.1 5.3 1.4e-07 -0.24 0.43 0.41 FALSE
4 GTEx Lung PHLPP2 0.16 0.15 enet 14 0.16 2.2e-12 5.1 5.1 2.9e-07 -0.23 0.52 0.48 FALSE
5 GTEx Skin Not Sun Exposed Suprapubic PHLPP2 0.19 0.15 lasso 1 0.14 4.2e-08 5.1 5.1 3.0e-07 -0.23 0.50 0.50 FALSE
6 GTEx Skin Sun Exposed Lower leg AP1G1 0.06 0.00 enet 15 0.01 5.7e-02 -4.9 -5.4 5.7e-08 0.54 0.18 0.62 FALSE
7 GTEx Spleen PHLPP2 0.18 0.11 lasso 13 0.09 2.2e-03 5.2 5.4 8.1e-08 -0.27 0.15 0.19 FALSE
8 GTEx Testis PHLPP2 0.29 0.38 enet 20 0.37 3.0e-17 -5.7 5.3 9.6e-08 -0.64 0.11 0.89 FALSE
9 METSIM Adipose PHLPP2 0.07 0.03 lasso 5 0.06 1.7e-09 4.9 6.1 1.2e-09 -0.46 0.87 0.13 FALSE
10 YFS Blood ATXN1L 0.02 0.02 blup 413 0.02 6.5e-07 4.4 5.9 2.9e-09 -0.45 0.94 0.05 FALSE
11 YFS Blood PHLPP2 0.04 0.03 bslmm 459 0.05 5.5e-16 -5.5 6.1 9.4e-10 -0.52 0.45 0.55 TRUE
12 The Cancer Genome Atlas Brain Lower Grade Glioma AP1G1 0.03 0.03 lasso 4 0.02 2.1e-03 -4.0 -5.1 2.8e-07 0.62 0.02 0.85 FALSE
13 The Cancer Genome Atlas Prostate Adenocarcinoma AP1G1 0.11 0.02 enet 27 0.04 1.2e-04 4.9 -5.8 6.4e-09 0.28 0.06 0.47 FALSE
14 The Cancer Genome Atlas Testicular Germ Cell Tumors PHLPP2 0.11 0.03 lasso 6 0.01 1.2e-01 4.8 6.0 2.0e-09 -0.43 0.03 0.43 FALSE
15 The Cancer Genome Atlas Thyroid Carcinoma MARVELD3 0.08 0.01 blup 44 0.06 7.1e-07 -5.5 6.0 2.4e-09 -0.49 0.04 0.94 FALSE
16 The Cancer Genome Atlas Thyroid Carcinoma PHLPP2 0.20 0.08 blup 67 0.14 1.4e-13 5.1 5.2 2.0e-07 -0.32 0.20 0.80 FALSE