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chr16:71,070,698-72,569,466

Best TWAS P=9.41e-10 · Best GWAS P=4.28e-11 conditioned to 6.2e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PHLPP2	0.04	0.01	bslmm	456	0.02	4.7e-04	-4.6	-5.7	1.4e-08	0.57	0.41	0.50	FALSE
2	GTEx	Adrenal Gland	AP1G1	0.22	0.06	enet	25	0.14	8.0e-06	-5.5	-5.2	1.8e-07	0.58	0.12	0.86	FALSE
3	GTEx	Heart Left Ventricle	PHLPP2	0.14	0.10	lasso	8	0.07	1.8e-04	5.1	5.3	1.4e-07	-0.24	0.43	0.41	FALSE
4	GTEx	Lung	PHLPP2	0.16	0.15	enet	14	0.16	2.2e-12	5.1	5.1	2.9e-07	-0.23	0.52	0.48	FALSE
5	GTEx	Skin Not Sun Exposed Suprapubic	PHLPP2	0.19	0.15	lasso	1	0.14	4.2e-08	5.1	5.1	3.0e-07	-0.23	0.50	0.50	FALSE
6	GTEx	Skin Sun Exposed Lower leg	AP1G1	0.06	0.00	enet	15	0.01	5.7e-02	-4.9	-5.4	5.7e-08	0.54	0.18	0.62	FALSE
7	GTEx	Spleen	PHLPP2	0.18	0.11	lasso	13	0.09	2.2e-03	5.2	5.4	8.1e-08	-0.27	0.15	0.19	FALSE
8	GTEx	Testis	PHLPP2	0.29	0.38	enet	20	0.37	3.0e-17	-5.7	5.3	9.6e-08	-0.64	0.11	0.89	FALSE
9	METSIM	Adipose	PHLPP2	0.07	0.03	lasso	5	0.06	1.7e-09	4.9	6.1	1.2e-09	-0.46	0.87	0.13	FALSE
10	YFS	Blood	ATXN1L	0.02	0.02	blup	413	0.02	6.5e-07	4.4	5.9	2.9e-09	-0.45	0.94	0.05	FALSE
11	YFS	Blood	PHLPP2	0.04	0.03	bslmm	459	0.05	5.5e-16	-5.5	6.1	9.4e-10	-0.52	0.45	0.55	TRUE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	AP1G1	0.03	0.03	lasso	4	0.02	2.1e-03	-4.0	-5.1	2.8e-07	0.62	0.02	0.85	FALSE
13	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP1G1	0.11	0.02	enet	27	0.04	1.2e-04	4.9	-5.8	6.4e-09	0.28	0.06	0.47	FALSE
14	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PHLPP2	0.11	0.03	lasso	6	0.01	1.2e-01	4.8	6.0	2.0e-09	-0.43	0.03	0.43	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	MARVELD3	0.08	0.01	blup	44	0.06	7.1e-07	-5.5	6.0	2.4e-09	-0.49	0.04	0.94	FALSE
16	The Cancer Genome Atlas	Thyroid Carcinoma	PHLPP2	0.20	0.08	blup	67	0.14	1.4e-13	5.1	5.2	2.0e-07	-0.32	0.20	0.80	FALSE