Hub : Genes

ATXN1L

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0685	0.0338	6.3e-03	0.020	NA	0.008	NA	0.017	1.3e-02	NA	0.08300	NA	2.2e-02
2	YFS	Blood	0.0225	0.0081	9.4e-06	0.017	0.019	0.011	0.018	0.011	2.1e-06	6.5e-07	0.00013	1e-06	9.7e-05
3	TCGA	Lung Squamous Cell Carcinoma	0.0383	0.0278	6.0e-03	0.009	0.010	0.017	NA	0.011	2.9e-02	2.5e-02	0.00420	NA	1.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	3.2	5.1	5.7	2.4	-2.0	-2.4
Bipolar Disorder or Schizophrenia	1.1	2.6	7.5	0.4	0.3	-2.7
Depressed Affect (Nagel 2018)	1.4	3.0	7.5	-1.1	2.7	0.4
Depression (Nagel 2018)	5.6	8.4	12.8	-3.4	3.6	1.1
Intelligence (Savage-Jansen 2018)	7.5	23.0	39.9	4.9	-6.3	-2.3
Neuroticism (Nagel 2018)	1.2	2.9	6.6	-1.4	2.6	-0.3
Schizophrenia (2018)	1.4	2.9	4.2	-1.4	2.1	-1.6
Schizophrenia vs Biploar Disorder	6.6	8.7	14.3	-3.8	3.3	1.1
Worry (Nagel 2018)	0.6	1.3	2.8	-0.8	1.7	-0.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.1	0.2	-0.8	1.1
Alzheimer’s Disease (in father)	0.8	0.8	1.8	-1.3	0.8	0.3
Alzheimer’s Disease (including proxy)	0.6	0.8	2.1	-0.6	-0.2	1.5
Crohns Disease (2017)	1.1	2.4	4.2	-1.4	0.9	2.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.4	-0.6	0.7	-0.3
Ulcerative Colitis (UC)	0.9	1.8	4.4	0.9	-0.2	-2.1
Major Depression (MDD)	0.7	0.9	1.5	-0.5	1.0	-1.2
Reaction Time	0.3	0.6	0.9	-0.5	-0.8	-1.0
Verbal and Numeric Reasoning (VNR)	4.9	11.8	25.9	2.9	-5.1	-1.1
Breast Cancer	2.7	6.4	15.6	1.9	-4.0	0.4
Ovarian Cancer	3.4	4.5	10.6	1.6	-3.3	-0.5
Prostate Cancer	1.4	2.0	3.6	-1.9	1.0	1.2
Age at First Birth	2.7	4.0	6.4	1.9	-2.5	-1.4
Bipolar Disorder (2011)	0.7	0.6	1.2	-0.2	-1.1	0.9
Body Mass Index (BMI) (2010)	1.2	1.7	3.8	-0.2	1.9	1.1
Coronary Artery Disease (CAD)	1.0	1.1	2.1	1.4	-1.1	0.3
Crohns Disease (2012)	0.6	0.9	1.2	-1.1	0.8	1.0
Mean Putamen Volume	0.5	0.6	1.3	0.4	-1.1	0.6
Fasting Glucose	1.2	1.5	1.8	-1.2	-1.0	1.4
HbA1C	0.1	0.1	0.3	-0.1	0.2	0.6
HDL Cholesterol	2.4	4.0	6.5	1.8	-2.5	-1.6
LDL Cholesterol	3.4	5.3	8.7	0.9	-3.0	2.5
Lupus	0.1	0.1	0.3	-0.0	-0.4	0.5
Neuroticism (2016)	0.6	0.8	1.4	1.2	0.6	-0.9
Primary Biliary Cirrhosis	0.5	0.7	0.9	1.0	-0.7	-0.8
Rheumatoid Arthritis	2.2	3.1	6.1	-2.5	1.6	-0.8
Schizophrenia (2014)	1.6	3.6	4.3	-1.9	2.1	-1.7
Triglycerides	0.6	1.0	2.5	0.6	-0.4	1.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	0.9	0.7	-1.0	-0.7
Ulcerative Colitis	1.7	2.5	6.4	1.0	-0.4	-2.5
Blood Eosinophil Count	0.4	3.2	6.4	-2.5	1.8	0.3
Blood Platelet Count	0.8	9.4	19.7	-2.4	4.4	-1.6
Blood Red Count	0.7	7.2	14.5	-0.9	-3.8	2.5
Blood White Count	0.4	2.9	5.4	-2.3	0.8	1.6
Heel T-Score	0.8	6.3	13.0	-3.6	1.1	2.2
BMI	0.5	3.2	8.7	-0.9	3.0	-0.2
Height	1.2	22.3	48.7	-3.4	7.0	2.5
Waist Hip Ratio (WHR)	0.6	2.6	5.0	-0.4	2.2	-1.6
Systolic Blood Pressure	3.4	17.2	42.2	3.0	-6.5	0.2
Smoking Status	1.5	3.5	5.9	2.4	0.6	-2.1
Allergy or Eczema	0.1	0.2	0.4	-0.6	-0.2	0.5
Cardiovascular Disease	2.8	9.3	19.0	2.8	-4.4	1.1
Hypothyroidism (self reported)	0.1	0.3	0.6	-0.3	0.4	-0.8
Respiratory disease	1.0	2.3	4.9	-1.2	2.2	0.7
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.4	-0.4	-1.6	0.3
Lung FEV1/FVC ratio	0.7	3.7	6.0	-0.4	2.2	-2.4
Lung FVC	1.4	6.9	9.0	-3.0	2.0	2.8
Neuroticism	2.0	4.8	11.6	-1.4	3.4	-0.9
Chronotype (morning person)	3.3	7.7	11.4	-3.0	1.7	3.4
Hair Pigment	0.3	8.4	13.7	3.2	-3.7	-1.0
Tanning	1.4	16.7	23.2	-4.8	4.3	2.9
Hand grip strength (left)	1.7	4.6	7.9	-1.8	2.8	1.6
Number of treatments/medications taken	0.6	1.1	2.4	1.6	-0.8	0.5
Average weekly spirits intake	0.2	0.2	0.4	0.6	-0.3	0.5
Sensitivity / hurt feelings	0.7	1.2	1.7	-1.1	1.3	0.8
Frequency of depressed mood in last 2 weeks	1.5	2.2	3.8	-1.3	1.9	1.0
Hearing difficulty/problems: Yes	7.7	11.8	19.3	-4.4	3.9	1.1
Relative age of first facial hair	0.3	0.6	1.2	0.5	1.1	-0.7
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	3.5	-1.6	1.9	-1.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	0.7	0.6	-1.4
Ever had hysterectomy (womb removed)	0.6	0.6	1.2	-0.7	1.1	0.5
Systolic blood pressure, automated reading	1.8	5.2	13.0	1.6	-3.6	-0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.1	-0.7	-0.4
Angina	0.0	0.0	0.1	0.1	-0.3	-0.2
Medication for hormone replacement therapy	0.5	0.6	1.1	1.1	0.0	-0.8
Vitamin and mineral supplements	2.9	3.9	8.8	-0.9	1.5	-3.0
Supplements: Zinc	1.1	1.2	3.0	-0.6	0.2	1.7
Medication: Co-codamol	0.8	1.0	1.7	-0.8	1.3	0.7
Medication: Metformin	0.7	1.0	1.3	-1.1	-0.9	1.0
Diabetes (father)	0.1	0.1	0.2	0.2	-0.3	-0.5
Diabetes (mother)	1.9	2.4	4.8	-2.2	1.5	-0.2
Severe depression (siblings)	0.5	0.5	1.4	1.2	-0.1	-0.4
Pack years adult smoking proportion	0.7	1.0	1.7	0.9	0.7	-1.3
Impedance of leg (right)	0.4	1.8	2.7	0.3	-1.6	1.6
Leg fat-free mass (left)	1.5	7.7	17.6	-2.4	4.2	0.1
Trunk fat percentage	0.7	2.8	4.4	-1.8	2.1	0.7
Hand grip strength (right)	1.4	3.7	9.5	-1.3	3.1	0.1
Townsend deprivation index at recruitment	0.5	0.8	1.9	-0.6	1.4	0.2
Current tobacco smoking	0.8	1.2	1.7	1.3	0.6	-1.3
Average weekly fortified wine intake	1.0	1.1	2.0	1.2	-0.3	-1.4
Maternal smoking around birth	0.4	0.6	1.7	-0.1	0.3	1.3
Fed-up feelings	3.4	6.2	13.4	-2.0	3.7	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	7.5	10.0	15.1	-3.9	3.6	1.5
Relative age voice broke	1.9	2.9	4.5	-1.3	2.1	1.6
Taking other prescription medications	0.7	1.0	2.7	-1.6	0.5	-0.4
Age when periods started (menarche)	1.1	2.8	6.1	-0.4	-1.4	2.5
Bilateral oophorectomy (both ovaries removed)	4.8	5.5	11.4	-1.2	3.4	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	5.4	-0.4	-1.2	2.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.0	0.8	-1.0	-0.9
Qualifications: CSEs or equivalent	0.4	0.5	0.6	-0.8	0.7	0.6
Serious illness, injury or assault to yourself	1.1	1.4	2.1	1.0	-1.5	-1.1
High blood pressure	2.4	6.6	10.9	3.0	-3.3	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.7	-0.6	-0.7	0.8
Multivitamins +/- minerals	3.3	4.3	7.5	1.3	-1.9	2.7
Stomach or abdominal pain in last month	4.5	5.6	10.6	-2.5	3.3	0.4
Supplements: Glucosamine	0.3	0.4	0.6	0.4	-0.7	0.8
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	3.6	-1.9	0.6	-0.5
Medication: Atenolol	1.7	2.1	4.7	1.2	-2.2	0.4
Medication: Levothyroxine sodium	2.5	4.2	7.1	2.1	-1.1	-2.7
Sitting height	1.9	13.4	14.8	-3.3	3.9	3.8
Chronic bronchitis/emphysema (father)	1.1	1.3	2.1	-1.4	0.3	1.3
High blood pressure (mother)	0.6	0.9	1.4	1.1	-1.2	0.1
Body mass index (BMI)	1.0	4.3	8.2	-2.1	2.9	-0.5
Impedance of leg (left)	0.2	1.2	2.0	0.3	-1.4	1.2
Leg predicted mass (left)	1.4	7.6	17.4	-2.3	4.2	0.1
Trunk fat mass	1.3	5.7	10.4	-2.4	3.2	0.8
Waist circumference	1.4	5.1	9.2	-2.4	3.0	-0.8
Number of incorrect matches in round	0.4	0.6	1.0	0.9	-0.3	-1.0
Past tobacco smoking	2.6	4.7	8.6	-2.9	0.8	2.2
Alcohol usually taken with meals	1.1	1.8	2.6	1.5	-1.6	-0.8
Nervous feelings	1.7	3.2	5.7	-1.6	2.4	-1.2
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	5.1	-1.8	2.2	1.0
Hearing difficulty/problems with background noise	4.8	7.6	11.6	-3.4	3.4	-0.1
Hair/balding pattern: Pattern 2	0.4	0.6	0.7	-0.7	-0.9	0.7
Had menopause	0.8	1.0	2.0	-1.4	0.5	1.0
Had other major operations	1.5	1.8	4.0	-2.0	1.1	0.4
Forced vital capacity (FVC)	2.9	11.0	13.6	-3.7	3.4	2.8
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	6.5	-1.1	-0.9	2.5
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	4.4	1.1	0.4	-2.1
Qualifications: None of the above	7.7	16.6	21.8	-4.2	4.7	3.2
Financial difficulties in last 2 years	2.3	3.1	5.0	2.1	-0.4	-2.2
Mouth/teeth dental problems	1.2	1.9	5.1	0.7	-2.3	-0.3
Heart attack	1.1	1.3	3.0	1.0	-1.7	-0.2
Allergy	0.0	0.1	0.1	0.2	0.2	-0.2
Pain all over the body in last month	2.2	2.4	5.4	-2.3	1.3	0.3
Diabetes (self-reported)	0.2	0.4	0.9	-0.9	-0.2	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.3	-0.4	-0.4
Medication: Ramipril	0.8	1.1	2.0	1.4	-1.0	-0.4
Medication: Simvastatin	2.0	3.0	7.3	0.9	-2.7	1.0
Fluid intelligence score	5.1	10.6	25.4	2.4	-5.0	-0.9
Illnesses of siblings	0.5	0.7	2.0	1.4	-0.3	-0.2
Neuroticism score	1.6	3.3	7.7	-1.3	2.8	0.7
Weight	1.9	9.4	19.9	-2.9	4.5	0.3
Impedance of arm (right)	2.0	9.2	15.3	3.5	-3.9	0.4
Arm fat percentage (right)	0.1	0.4	1.0	-0.4	1.0	-0.4
Trunk fat-free mass	2.4	13.9	30.1	-3.4	5.5	0.2
Hip circumference	0.4	1.9	3.2	-1.6	1.8	0.1
Time employed in main current job	0.9	1.0	2.4	0.4	-0.6	1.6
Alcohol intake versus 10 years previously	3.5	5.2	8.2	-2.6	0.9	2.9
Father’s age at death	0.1	0.1	0.2	0.5	-0.2	-0.3
Worrier / anxious feelings	0.2	0.3	0.5	-0.0	-0.7	0.7
Frequency of tiredness / lethargy in last 2 weeks	6.3	10.3	16.5	-4.1	3.1	2.1
Falls in the last year	2.9	3.9	4.8	2.1	-1.5	-2.2
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	-0.7	0.6	0.4
Number of live births	5.4	7.7	12.4	-3.3	3.5	0.1
Forced expiratory volume in 1-second (FEV1)	3.1	10.6	14.4	-3.8	3.8	1.8
Pulse rate	1.2	2.0	3.2	-1.4	1.8	-0.9
Happiness	1.7	2.0	4.8	0.6	2.2	-1.0
Noisy workplace	0.8	1.0	2.4	-0.6	1.6	0.5
Qualifications: A levels/AS levels or equivalent	3.0	6.5	7.9	2.0	-2.8	-2.7
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	5.3	0.4	-2.3	-0.8
Mouth/teeth dental problems: Dentures	1.2	2.0	4.6	-1.1	0.4	2.1
Asthma	0.0	0.1	0.2	-0.5	0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	1.6	1.3	0.8	-1.1
Medication: Cholesterol lowering	4.1	6.4	10.8	2.8	-3.3	0.9
Depression (self-reported)	0.9	1.0	1.9	0.8	-0.8	-1.4
Medication: Lansoprazole	0.8	0.9	1.6	0.3	-0.9	1.3
Prospective memory result	3.9	4.7	8.5	-1.8	2.9	1.6
Lung cancer (father)	0.2	0.2	0.5	0.7	0.3	0.3
Illnesses of mother	0.2	0.3	0.6	-0.3	0.8	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.7	15.0	-3.3	3.9	1.7
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	0.2	-0.2	-0.6
Impedance of arm (left)	1.4	6.5	11.3	2.8	-3.4	0.7
Arm fat mass (right)	1.0	3.9	8.7	-1.7	3.0	-0.3
Trunk predicted mass	2.5	14.1	30.9	-3.4	5.6	0.1
Standing height	1.1	10.6	22.4	-2.4	4.7	1.9
Length of working week for main job	4.8	5.4	7.0	2.6	-2.2	-2.1
Exposure to tobacco smoke at home	0.3	0.4	0.5	-0.3	0.7	0.7
Breastfed as a baby	0.5	0.6	1.2	1.1	0.3	0.6
Tense / ‘highly strung’	1.4	2.3	5.6	-0.9	2.4	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.7	0.1	1.7	-0.7
Hair/balding pattern: Pattern 4	0.2	0.4	0.7	0.0	-0.7	0.8
Birth weight of first child	0.4	0.8	1.3	0.6	0.9	-1.1
Peak expiratory flow (PEF)	0.9	2.1	4.2	-1.3	2.0	0.6
Pulse wave reflection index	1.1	1.3	2.4	1.6	-1.3	-0.1
Ever highly irritable/argumentative for 2 days	2.2	2.7	6.3	-1.3	2.5	-0.1
Loud music exposure frequency	3.1	3.4	9.8	-0.6	3.1	0.1
Qualifications: O levels/GCSEs or equivalent	3.7	5.9	13.8	1.9	-3.7	-0.5
Mouth/teeth dental problems: Bleeding gums	1.7	2.1	5.6	0.6	0.7	-2.4
Blood clot in the leg (DVT)	0.1	0.2	0.2	0.3	0.5	-0.3
Medication: Paracetamol	1.2	2.0	4.1	-1.3	2.0	0.4
Headache pain in last month	0.6	1.1	2.8	-0.4	1.7	0.4
Medication for cholesterol, blood pressure or diabetes	2.0	3.3	6.2	-1.7	2.5	-0.9
Glaucoma (self-reported)	1.3	1.5	4.4	-0.1	0.2	2.1
Gout (self-reported)	1.8	2.5	6.7	0.8	-0.5	-2.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	0.8	0.8	-0.5	-0.9
Medication: Amlodipine	0.1	0.1	0.3	0.3	-0.0	-0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.2	-0.7	0.4	1.1
Birth weight	1.9	4.1	6.4	2.5	-1.2	-2.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.8	-0.9	0.5	-0.4
High blood pressure (siblings)	0.1	0.1	0.2	0.4	-0.4	-0.3
Forced vital capacity (FVC), Best measure	3.7	13.5	16.2	-4.0	4.0	2.9
Body fat percentage	0.6	2.2	3.5	-1.7	1.9	0.5
Leg fat percentage (right)	0.5	1.8	3.1	-1.5	1.8	0.2
Arm fat-free mass (right)	3.5	17.9	35.3	-4.3	5.9	0.4
Exposure to tobacco smoke outside home	0.5	0.6	1.6	0.4	0.1	-1.3
Comparative body size at age 10	0.7	2.0	5.2	-0.8	0.1	2.3
Number of full brothers	1.0	1.3	3.6	-0.4	0.2	1.9
Worry too long after embarrassment	0.5	0.8	1.3	-1.2	1.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	5.0	-1.2	2.2	-1.2
Wheeze or whistling in the chest in last year	0.7	1.3	1.9	-1.1	0.7	1.4
Number of children fathered	1.7	1.9	3.1	-1.7	1.6	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.8	-0.3	0.2
Age at first live birth	3.8	6.8	12.1	2.7	-3.5	-1.0
Pulse wave peak to peak time	0.3	0.4	0.7	-0.5	0.4	0.8
Health satisfaction	2.9	3.7	6.2	-1.7	2.5	-1.4
Shortness of breath walking on level ground	3.3	3.9	7.8	-1.9	2.8	-0.2
Qualifications: College or University degree	7.0	22.1	25.9	5.1	-4.2	-4.8
Eye problems/disorders: None of the above	0.5	0.6	1.4	-0.6	0.3	-1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.8	0.7	0.5	-1.3
Emphysema/chronic bronchitis	4.6	5.1	5.7	-2.2	2.4	2.2
Medication for pain relief, constipation, heartburn	0.6	0.9	1.9	-0.9	-1.4	0.3
Neck or shoulder pain in last month	13.4	19.0	31.5	-4.4	5.6	2.4
Medication: Blood pressure	0.6	1.0	2.0	1.0	-1.4	0.0
Angina (self-reported)	0.0	0.0	0.0	-0.0	-0.2	-0.0
Migraine (self-reported)	0.6	0.8	1.8	1.3	-0.4	-0.6
Medication: Ibuprofen	0.8	1.0	2.2	1.5	0.5	-0.7
Medication: Allopurinol	1.3	1.8	4.2	1.0	-0.2	-2.0
Medication: Omeprazole	0.5	0.6	1.2	0.3	0.6	-1.1
Medication: Seretide 50 evohaler	0.2	0.3	0.4	-0.5	0.7	0.4
Mean time to correctly identify matches	0.3	0.5	1.1	-0.2	-0.6	-1.1
Heart disease (mother)	0.2	0.3	0.6	-0.3	-0.3	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.2	-0.9	1.1	0.5
Whole body fat mass	1.3	5.5	10.4	-2.4	3.2	0.6
Leg fat mass (right)	1.2	4.7	8.8	-2.3	3.0	0.5
Arm predicted mass (right)	3.4	17.2	33.4	-4.2	5.8	0.5
Pulse rate, automated reading	1.3	4.3	6.4	-2.5	2.5	-0.6
Alcohol intake frequency.	5.9	13.6	25.1	-3.3	2.2	5.0
Comparative height size at age 10	2.5	13.8	31.6	-2.9	5.6	1.2
Number of full sisters	0.8	1.0	2.3	-1.5	0.7	0.5
Suffer from ‘nerves’	0.3	0.4	1.3	0.1	1.1	0.1
Overall health rating	8.3	17.8	27.7	-5.0	5.3	0.8
Chest pain or discomfort	0.5	0.7	1.6	-0.7	0.1	-1.3
Had major operations	0.2	0.2	0.3	0.4	-0.6	0.3
Age at last live birth	1.7	2.5	4.4	2.1	-1.7	-0.2
Family relationship satisfaction	2.1	2.6	5.2	-1.5	2.3	0.6
Leg pain on walking	1.4	1.7	2.3	-1.4	1.5	-1.0
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	-0.4	0.2	-0.6
Commuting to job workplace: Car/motor vehicle	4.7	5.4	10.7	-2.2	3.3	-0.7
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.7	-1.0	0.1	1.6
Medication: Aspirin	2.5	3.4	6.2	2.5	-1.9	-0.5
Supplements: Vitamin C	0.5	0.6	1.9	0.0	0.2	1.4
Knee pain experienced in last month	4.4	6.8	11.1	-3.3	3.0	0.6
Hypertension (Self-reported)	2.0	5.6	9.0	2.8	-3.0	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.2	0.5	0.3	0.5
Illnesses of father: Heart disease	0.6	0.8	1.7	0.6	1.3	0.7
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.4	0.1	-1.2
Smoking status: Previous	1.1	1.6	3.9	2.0	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.9	-0.4	1.4	0.8
Whole body fat-free mass	2.2	12.7	27.5	-3.3	5.2	0.1
Leg fat-free mass (right)	1.5	7.9	18.3	-2.3	4.3	-0.2
Arm fat percentage (left)	0.2	0.8	1.7	-0.8	1.3	-0.3
Average weekly red wine intake	1.9	2.8	3.1	1.8	-1.7	-1.6
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	0.1	0.2	-0.1
Mood swings	1.5	2.7	6.4	-1.2	2.5	0.4
Loneliness, isolation	0.9	1.2	2.0	-1.0	1.4	0.8
Long-standing illness, disability or infirmity	0.4	0.6	0.9	-0.8	0.9	-0.5
Ever had bowel cancer screening	2.7	3.2	4.7	-2.2	1.7	1.4
Diabetes diagnosed by doctor	0.4	0.6	1.3	-0.4	-1.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.2	-0.6	0.1
Friendships satisfaction	1.0	1.3	1.9	0.1	1.4	-1.4
Qualifications: nursing, teaching	2.8	4.3	7.0	2.3	-2.7	-0.9
Commuting to job workplace: Walk	1.9	2.0	5.8	0.6	-2.4	-0.2
Eye problems/disorders: Cataract	1.2	1.4	2.0	1.1	-1.4	1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	-0.0	1.2	0.5
Medication for cholesterol	1.5	2.3	3.6	-1.8	1.9	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	-1.0	-0.1	0.2
Back pain experienced in last month	8.7	12.7	17.8	-4.2	4.0	2.1
Mineral and other dietary supplements	4.1	5.5	14.3	-0.3	1.4	-3.8
Breast cancer (self-reported)	2.8	3.4	6.1	-2.0	2.5	-0.2
Asthma (self-reported)	0.1	0.1	0.4	-0.6	0.2	0.1
Osteoporosis (self-reported)	1.7	2.1	3.9	2.0	-1.2	-1.1
Osteoarthritis (self-reported)	0.8	1.1	2.3	-0.9	0.0	1.5
Medication: Aspirin	1.8	2.3	4.1	2.0	-1.7	-0.0
Medication: Gliclazide	0.6	0.7	1.4	-1.2	0.8	-0.0
Illnesses of father: None of the above (group 1)	1.2	1.4	3.3	1.0	-0.3	-1.8
Smoking status: Current	0.9	1.4	1.9	1.4	0.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.6	7.6	11.6	-3.4	2.7	2.0
Whole body water mass	2.2	12.7	27.7	-3.2	5.3	0.1
Leg predicted mass (right)	1.5	7.9	18.3	-2.3	4.3	-0.2
Arm fat mass (left)	1.2	5.0	10.3	-2.1	3.2	-0.1
Number of self-reported non-cancer illnesses	0.5	0.9	1.5	1.1	-1.2	-0.1
Average weekly champagne plus white wine intake	0.0	0.1	0.1	-0.0	-0.3	-0.3
Miserableness	0.4	0.7	0.9	0.8	0.7	-1.0
Guilty feelings	1.1	1.7	2.0	-1.3	1.4	1.1
Wears glasses or contact lenses	2.5	2.8	3.2	1.7	-1.8	-1.6
Ever taken oral contraceptive pill	1.9	2.1	4.1	1.5	-0.3	-2.0
Hearing aid user	0.9	1.0	2.9	-0.4	0.1	1.7
Mother’s age at death	0.6	0.7	1.3	-1.2	0.1	0.9
Financial situation satisfaction	1.0	1.2	1.4	1.2	1.0	-1.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.1	0.5	-0.1
Commuting to job workplace: Public transport	5.6	6.7	10.0	2.3	-3.2	-2.2
Eye problems/disorders: Glaucoma	2.8	3.4	9.6	-0.5	-0.5	3.1
Medication: Blood pressure	2.7	5.1	8.0	2.8	-2.7	-0.2
Pain type(s) experienced in last month: Hip pain	4.0	5.1	5.5	-2.3	2.3	2.1
Supplements: Fish oil (including cod liver oil)	2.7	3.5	9.9	0.2	-0.8	3.1
High cholesterol (Self-reported)	2.9	5.2	9.8	0.6	-3.1	2.3
Medication: Bendroflumethiazide	3.6	5.4	9.4	3.1	-2.3	-1.3
Medication: Paracetamol	0.8	1.3	2.4	-1.2	1.5	0.3
Medication: Lisinopril	1.7	2.2	3.9	1.6	-2.0	-0.5
Medication: Atorvastatin	4.6	5.7	10.4	2.6	-3.2	-0.4
Illnesses of father: High blood pressure	2.1	2.6	4.3	1.8	-2.1	-0.6
Alcohol drinker status: Never	1.3	1.5	2.8	0.2	-1.3	1.7
Ever smoked	2.9	5.0	9.7	2.3	-0.1	-3.1
Basal metabolic rate	2.2	12.3	26.5	-3.2	5.2	0.2
Leg fat percentage (left)	0.7	2.4	4.3	-1.7	2.1	0.0
Arm fat-free mass (left)	3.2	16.1	32.5	-4.0	5.7	0.3
Number of operations (self-reported)	0.9	1.4	3.2	-0.9	1.8	-0.4
Average weekly beer plus cider intake	0.8	1.2	2.6	-1.0	1.6	0.1
Irritability	2.1	3.5	7.1	-1.5	2.7	1.0
Risk taking	1.8	2.7	5.2	1.5	0.8	-2.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.9	-1.4	0.0	0.6
Fractured/broken bones in last 5 years	0.8	1.1	2.0	1.1	-0.0	-1.4
Age started oral contraceptive pill	1.3	1.6	2.5	1.2	-1.6	1.0
Diastolic blood pressure, automated reading	2.3	7.3	12.1	3.5	-2.8	-1.4
Ever depressed for a whole week	1.1	1.3	2.2	1.0	0.9	-1.5
Unable to work because of sickness or disability	0.9	1.2	2.4	-1.6	0.9	0.4
Commuting to job workplace: Cycle	0.8	1.0	1.2	1.1	-1.0	0.8
Myopia	0.1	0.2	0.3	-0.6	0.3	0.2
Vascular/heart problems diagnosed by doctor	2.3	6.4	11.0	-2.8	3.3	0.3
Cholesterol lowering medication	1.8	2.6	4.5	-0.4	-2.1	1.8
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.1	0.2	0.1
Pain experienced in last month	11.7	19.5	33.1	4.9	-5.8	-1.3
Supplements: Calcium	1.4	1.5	2.8	1.7	-1.3	-0.3
Basal cell carcinoma (self-reported)	1.5	1.8	4.2	-0.8	-0.8	2.1
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.5	1.0	-1.6	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.0	-0.0	1.0	-0.0
Heart disease (siblings)	2.7	3.3	5.2	-2.3	1.0	2.0
Alcohol drinker status: Previous	0.5	0.6	1.0	-0.3	1.0	0.8
Pack years of smoking	0.7	1.0	1.7	1.2	0.2	-1.3
Impedance of whole body	0.6	3.1	5.6	1.4	-2.4	1.3
Leg fat mass (left)	1.4	5.5	10.4	-2.4	3.2	0.3
Arm predicted mass (left)	3.1	15.5	30.8	-4.0	5.5	0.2