Hub : Genes

ATXN1L

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0685 0.0338 6.3e-03 0.020 NA 0.008 NA 0.017 1.3e-02 NA 0.08300 NA 2.2e-02
2 YFS Blood 0.0225 0.0081 9.4e-06 0.017 0.019 0.011 0.018 0.011 2.1e-06 6.5e-07 0.00013 1e-06 9.7e-05
3 TCGA Lung Squamous Cell Carcinoma 0.0383 0.0278 6.0e-03 0.009 0.010 0.017 NA 0.011 2.9e-02 2.5e-02 0.00420 NA 1.8e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 3.2 5.1 5.7 2.4 -2.0 -2.4
Bipolar Disorder or Schizophrenia 1.1 2.6 7.5 0.4 0.3 -2.7
Depressed Affect (Nagel 2018) 1.4 3.0 7.5 -1.1 2.7 0.4
Depression (Nagel 2018) 5.6 8.4 12.8 -3.4 3.6 1.1
Intelligence (Savage-Jansen 2018) 7.5 23.0 39.9 4.9 -6.3 -2.3
Neuroticism (Nagel 2018) 1.2 2.9 6.6 -1.4 2.6 -0.3
Schizophrenia (2018) 1.4 2.9 4.2 -1.4 2.1 -1.6
Schizophrenia vs Biploar Disorder 6.6 8.7 14.3 -3.8 3.3 1.1
Worry (Nagel 2018) 0.6 1.3 2.8 -0.8 1.7 -0.7
Alzheimer’s Disease (in mother) 0.5 0.6 1.1 0.2 -0.8 1.1
Alzheimer’s Disease (in father) 0.8 0.8 1.8 -1.3 0.8 0.3
Alzheimer’s Disease (including proxy) 0.6 0.8 2.1 -0.6 -0.2 1.5
Crohns Disease (2017) 1.1 2.4 4.2 -1.4 0.9 2.1
Irritable Bowel Disease (IBD) 0.1 0.3 0.4 -0.6 0.7 -0.3
Ulcerative Colitis (UC) 0.9 1.8 4.4 0.9 -0.2 -2.1
Major Depression (MDD) 0.7 0.9 1.5 -0.5 1.0 -1.2
Reaction Time 0.3 0.6 0.9 -0.5 -0.8 -1.0
Verbal and Numeric Reasoning (VNR) 4.9 11.8 25.9 2.9 -5.1 -1.1
Breast Cancer 2.7 6.4 15.6 1.9 -4.0 0.4
Ovarian Cancer 3.4 4.5 10.6 1.6 -3.3 -0.5
Prostate Cancer 1.4 2.0 3.6 -1.9 1.0 1.2
Age at First Birth 2.7 4.0 6.4 1.9 -2.5 -1.4
Bipolar Disorder (2011) 0.7 0.6 1.2 -0.2 -1.1 0.9
Body Mass Index (BMI) (2010) 1.2 1.7 3.8 -0.2 1.9 1.1
Coronary Artery Disease (CAD) 1.0 1.1 2.1 1.4 -1.1 0.3
Crohns Disease (2012) 0.6 0.9 1.2 -1.1 0.8 1.0
Mean Putamen Volume 0.5 0.6 1.3 0.4 -1.1 0.6
Fasting Glucose 1.2 1.5 1.8 -1.2 -1.0 1.4
HbA1C 0.1 0.1 0.3 -0.1 0.2 0.6
HDL Cholesterol 2.4 4.0 6.5 1.8 -2.5 -1.6
LDL Cholesterol 3.4 5.3 8.7 0.9 -3.0 2.5
Lupus 0.1 0.1 0.3 -0.0 -0.4 0.5
Neuroticism (2016) 0.6 0.8 1.4 1.2 0.6 -0.9
Primary Biliary Cirrhosis 0.5 0.7 0.9 1.0 -0.7 -0.8
Rheumatoid Arthritis 2.2 3.1 6.1 -2.5 1.6 -0.8
Schizophrenia (2014) 1.6 3.6 4.3 -1.9 2.1 -1.7
Triglycerides 0.6 1.0 2.5 0.6 -0.4 1.6
Type 2 Diabetes (T2D) (2012) 0.6 0.7 0.9 0.7 -1.0 -0.7
Ulcerative Colitis 1.7 2.5 6.4 1.0 -0.4 -2.5
Blood Eosinophil Count 0.4 3.2 6.4 -2.5 1.8 0.3
Blood Platelet Count 0.8 9.4 19.7 -2.4 4.4 -1.6
Blood Red Count 0.7 7.2 14.5 -0.9 -3.8 2.5
Blood White Count 0.4 2.9 5.4 -2.3 0.8 1.6
Heel T-Score 0.8 6.3 13.0 -3.6 1.1 2.2
BMI 0.5 3.2 8.7 -0.9 3.0 -0.2
Height 1.2 22.3 48.7 -3.4 7.0 2.5
Waist Hip Ratio (WHR) 0.6 2.6 5.0 -0.4 2.2 -1.6
Systolic Blood Pressure 3.4 17.2 42.2 3.0 -6.5 0.2
Smoking Status 1.5 3.5 5.9 2.4 0.6 -2.1
Allergy or Eczema 0.1 0.2 0.4 -0.6 -0.2 0.5
Cardiovascular Disease 2.8 9.3 19.0 2.8 -4.4 1.1
Hypothyroidism (self reported) 0.1 0.3 0.6 -0.3 0.4 -0.8
Respiratory disease 1.0 2.3 4.9 -1.2 2.2 0.7
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.4 -0.4 -1.6 0.3
Lung FEV1/FVC ratio 0.7 3.7 6.0 -0.4 2.2 -2.4
Lung FVC 1.4 6.9 9.0 -3.0 2.0 2.8
Neuroticism 2.0 4.8 11.6 -1.4 3.4 -0.9
Chronotype (morning person) 3.3 7.7 11.4 -3.0 1.7 3.4
Hair Pigment 0.3 8.4 13.7 3.2 -3.7 -1.0
Tanning 1.4 16.7 23.2 -4.8 4.3 2.9
Hand grip strength (left) 1.7 4.6 7.9 -1.8 2.8 1.6
Number of treatments/medications taken 0.6 1.1 2.4 1.6 -0.8 0.5
Average weekly spirits intake 0.2 0.2 0.4 0.6 -0.3 0.5
Sensitivity / hurt feelings 0.7 1.2 1.7 -1.1 1.3 0.8
Frequency of depressed mood in last 2 weeks 1.5 2.2 3.8 -1.3 1.9 1.0
Hearing difficulty/problems: Yes 7.7 11.8 19.3 -4.4 3.9 1.1
Relative age of first facial hair 0.3 0.6 1.2 0.5 1.1 -0.7
Other serious medical condition/disability diagnosed by doctor 2.0 2.6 3.5 -1.6 1.9 -1.3
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.0 0.7 0.6 -1.4
Ever had hysterectomy (womb removed) 0.6 0.6 1.2 -0.7 1.1 0.5
Systolic blood pressure, automated reading 1.8 5.2 13.0 1.6 -3.6 -0.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.4 0.1 -0.7 -0.4
Angina 0.0 0.0 0.1 0.1 -0.3 -0.2
Medication for hormone replacement therapy 0.5 0.6 1.1 1.1 0.0 -0.8
Vitamin and mineral supplements 2.9 3.9 8.8 -0.9 1.5 -3.0
Supplements: Zinc 1.1 1.2 3.0 -0.6 0.2 1.7
Medication: Co-codamol 0.8 1.0 1.7 -0.8 1.3 0.7
Medication: Metformin 0.7 1.0 1.3 -1.1 -0.9 1.0
Diabetes (father) 0.1 0.1 0.2 0.2 -0.3 -0.5
Diabetes (mother) 1.9 2.4 4.8 -2.2 1.5 -0.2
Severe depression (siblings) 0.5 0.5 1.4 1.2 -0.1 -0.4
Pack years adult smoking proportion 0.7 1.0 1.7 0.9 0.7 -1.3
Impedance of leg (right) 0.4 1.8 2.7 0.3 -1.6 1.6
Leg fat-free mass (left) 1.5 7.7 17.6 -2.4 4.2 0.1
Trunk fat percentage 0.7 2.8 4.4 -1.8 2.1 0.7
Hand grip strength (right) 1.4 3.7 9.5 -1.3 3.1 0.1
Townsend deprivation index at recruitment 0.5 0.8 1.9 -0.6 1.4 0.2
Current tobacco smoking 0.8 1.2 1.7 1.3 0.6 -1.3
Average weekly fortified wine intake 1.0 1.1 2.0 1.2 -0.3 -1.4
Maternal smoking around birth 0.4 0.6 1.7 -0.1 0.3 1.3
Fed-up feelings 3.4 6.2 13.4 -2.0 3.7 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 7.5 10.0 15.1 -3.9 3.6 1.5
Relative age voice broke 1.9 2.9 4.5 -1.3 2.1 1.6
Taking other prescription medications 0.7 1.0 2.7 -1.6 0.5 -0.4
Age when periods started (menarche) 1.1 2.8 6.1 -0.4 -1.4 2.5
Bilateral oophorectomy (both ovaries removed) 4.8 5.5 11.4 -1.2 3.4 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.3 5.4 -0.4 -1.2 2.3
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 1.0 0.8 -1.0 -0.9
Qualifications: CSEs or equivalent 0.4 0.5 0.6 -0.8 0.7 0.6
Serious illness, injury or assault to yourself 1.1 1.4 2.1 1.0 -1.5 -1.1
High blood pressure 2.4 6.6 10.9 3.0 -3.3 -0.1
Hayfever, allergic rhinitis or eczema 0.2 0.5 0.7 -0.6 -0.7 0.8
Multivitamins +/- minerals 3.3 4.3 7.5 1.3 -1.9 2.7
Stomach or abdominal pain in last month 4.5 5.6 10.6 -2.5 3.3 0.4
Supplements: Glucosamine 0.3 0.4 0.6 0.4 -0.7 0.8
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 3.6 -1.9 0.6 -0.5
Medication: Atenolol 1.7 2.1 4.7 1.2 -2.2 0.4
Medication: Levothyroxine sodium 2.5 4.2 7.1 2.1 -1.1 -2.7
Sitting height 1.9 13.4 14.8 -3.3 3.9 3.8
Chronic bronchitis/emphysema (father) 1.1 1.3 2.1 -1.4 0.3 1.3
High blood pressure (mother) 0.6 0.9 1.4 1.1 -1.2 0.1
Body mass index (BMI) 1.0 4.3 8.2 -2.1 2.9 -0.5
Impedance of leg (left) 0.2 1.2 2.0 0.3 -1.4 1.2
Leg predicted mass (left) 1.4 7.6 17.4 -2.3 4.2 0.1
Trunk fat mass 1.3 5.7 10.4 -2.4 3.2 0.8
Waist circumference 1.4 5.1 9.2 -2.4 3.0 -0.8
Number of incorrect matches in round 0.4 0.6 1.0 0.9 -0.3 -1.0
Past tobacco smoking 2.6 4.7 8.6 -2.9 0.8 2.2
Alcohol usually taken with meals 1.1 1.8 2.6 1.5 -1.6 -0.8
Nervous feelings 1.7 3.2 5.7 -1.6 2.4 -1.2
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 5.1 -1.8 2.2 1.0
Hearing difficulty/problems with background noise 4.8 7.6 11.6 -3.4 3.4 -0.1
Hair/balding pattern: Pattern 2 0.4 0.6 0.7 -0.7 -0.9 0.7
Had menopause 0.8 1.0 2.0 -1.4 0.5 1.0
Had other major operations 1.5 1.8 4.0 -2.0 1.1 0.4
Forced vital capacity (FVC) 2.9 11.0 13.6 -3.7 3.4 2.8
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 6.5 -1.1 -0.9 2.5
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 4.4 1.1 0.4 -2.1
Qualifications: None of the above 7.7 16.6 21.8 -4.2 4.7 3.2
Financial difficulties in last 2 years 2.3 3.1 5.0 2.1 -0.4 -2.2
Mouth/teeth dental problems 1.2 1.9 5.1 0.7 -2.3 -0.3
Heart attack 1.1 1.3 3.0 1.0 -1.7 -0.2
Allergy 0.0 0.1 0.1 0.2 0.2 -0.2
Pain all over the body in last month 2.2 2.4 5.4 -2.3 1.3 0.3
Diabetes (self-reported) 0.2 0.4 0.9 -0.9 -0.2 -0.4
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 0.3 -0.4 -0.4
Medication: Ramipril 0.8 1.1 2.0 1.4 -1.0 -0.4
Medication: Simvastatin 2.0 3.0 7.3 0.9 -2.7 1.0
Fluid intelligence score 5.1 10.6 25.4 2.4 -5.0 -0.9
Illnesses of siblings 0.5 0.7 2.0 1.4 -0.3 -0.2
Neuroticism score 1.6 3.3 7.7 -1.3 2.8 0.7
Weight 1.9 9.4 19.9 -2.9 4.5 0.3
Impedance of arm (right) 2.0 9.2 15.3 3.5 -3.9 0.4
Arm fat percentage (right) 0.1 0.4 1.0 -0.4 1.0 -0.4
Trunk fat-free mass 2.4 13.9 30.1 -3.4 5.5 0.2
Hip circumference 0.4 1.9 3.2 -1.6 1.8 0.1
Time employed in main current job 0.9 1.0 2.4 0.4 -0.6 1.6
Alcohol intake versus 10 years previously 3.5 5.2 8.2 -2.6 0.9 2.9
Father’s age at death 0.1 0.1 0.2 0.5 -0.2 -0.3
Worrier / anxious feelings 0.2 0.3 0.5 -0.0 -0.7 0.7
Frequency of tiredness / lethargy in last 2 weeks 6.3 10.3 16.5 -4.1 3.1 2.1
Falls in the last year 2.9 3.9 4.8 2.1 -1.5 -2.2
Hair/balding pattern: Pattern 3 0.2 0.3 0.4 -0.7 0.6 0.4
Number of live births 5.4 7.7 12.4 -3.3 3.5 0.1
Forced expiratory volume in 1-second (FEV1) 3.1 10.6 14.4 -3.8 3.8 1.8
Pulse rate 1.2 2.0 3.2 -1.4 1.8 -0.9
Happiness 1.7 2.0 4.8 0.6 2.2 -1.0
Noisy workplace 0.8 1.0 2.4 -0.6 1.6 0.5
Qualifications: A levels/AS levels or equivalent 3.0 6.5 7.9 2.0 -2.8 -2.7
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.1 5.3 0.4 -2.3 -0.8
Mouth/teeth dental problems: Dentures 1.2 2.0 4.6 -1.1 0.4 2.1
Asthma 0.0 0.1 0.2 -0.5 0.1 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 1.6 1.3 0.8 -1.1
Medication: Cholesterol lowering 4.1 6.4 10.8 2.8 -3.3 0.9
Depression (self-reported) 0.9 1.0 1.9 0.8 -0.8 -1.4
Medication: Lansoprazole 0.8 0.9 1.6 0.3 -0.9 1.3
Prospective memory result 3.9 4.7 8.5 -1.8 2.9 1.6
Lung cancer (father) 0.2 0.2 0.5 0.7 0.3 0.3
Illnesses of mother 0.2 0.3 0.6 -0.3 0.8 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 9.7 15.0 -3.3 3.9 1.7
Pulse wave Arterial Stiffness index 0.1 0.2 0.4 0.2 -0.2 -0.6
Impedance of arm (left) 1.4 6.5 11.3 2.8 -3.4 0.7
Arm fat mass (right) 1.0 3.9 8.7 -1.7 3.0 -0.3
Trunk predicted mass 2.5 14.1 30.9 -3.4 5.6 0.1
Standing height 1.1 10.6 22.4 -2.4 4.7 1.9
Length of working week for main job 4.8 5.4 7.0 2.6 -2.2 -2.1
Exposure to tobacco smoke at home 0.3 0.4 0.5 -0.3 0.7 0.7
Breastfed as a baby 0.5 0.6 1.2 1.1 0.3 0.6
Tense / ‘highly strung’ 1.4 2.3 5.6 -0.9 2.4 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 2.7 0.1 1.7 -0.7
Hair/balding pattern: Pattern 4 0.2 0.4 0.7 0.0 -0.7 0.8
Birth weight of first child 0.4 0.8 1.3 0.6 0.9 -1.1
Peak expiratory flow (PEF) 0.9 2.1 4.2 -1.3 2.0 0.6
Pulse wave reflection index 1.1 1.3 2.4 1.6 -1.3 -0.1
Ever highly irritable/argumentative for 2 days 2.2 2.7 6.3 -1.3 2.5 -0.1
Loud music exposure frequency 3.1 3.4 9.8 -0.6 3.1 0.1
Qualifications: O levels/GCSEs or equivalent 3.7 5.9 13.8 1.9 -3.7 -0.5
Mouth/teeth dental problems: Bleeding gums 1.7 2.1 5.6 0.6 0.7 -2.4
Blood clot in the leg (DVT) 0.1 0.2 0.2 0.3 0.5 -0.3
Medication: Paracetamol 1.2 2.0 4.1 -1.3 2.0 0.4
Headache pain in last month 0.6 1.1 2.8 -0.4 1.7 0.4
Medication for cholesterol, blood pressure or diabetes 2.0 3.3 6.2 -1.7 2.5 -0.9
Glaucoma (self-reported) 1.3 1.5 4.4 -0.1 0.2 2.1
Gout (self-reported) 1.8 2.5 6.7 0.8 -0.5 -2.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 0.8 0.8 -0.5 -0.9
Medication: Amlodipine 0.1 0.1 0.3 0.3 -0.0 -0.6
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.2 -0.7 0.4 1.1
Birth weight 1.9 4.1 6.4 2.5 -1.2 -2.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 0.8 -0.9 0.5 -0.4
High blood pressure (siblings) 0.1 0.1 0.2 0.4 -0.4 -0.3
Forced vital capacity (FVC), Best measure 3.7 13.5 16.2 -4.0 4.0 2.9
Body fat percentage 0.6 2.2 3.5 -1.7 1.9 0.5
Leg fat percentage (right) 0.5 1.8 3.1 -1.5 1.8 0.2
Arm fat-free mass (right) 3.5 17.9 35.3 -4.3 5.9 0.4
Exposure to tobacco smoke outside home 0.5 0.6 1.6 0.4 0.1 -1.3
Comparative body size at age 10 0.7 2.0 5.2 -0.8 0.1 2.3
Number of full brothers 1.0 1.3 3.6 -0.4 0.2 1.9
Worry too long after embarrassment 0.5 0.8 1.3 -1.2 1.0 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.6 5.0 -1.2 2.2 -1.2
Wheeze or whistling in the chest in last year 0.7 1.3 1.9 -1.1 0.7 1.4
Number of children fathered 1.7 1.9 3.1 -1.7 1.6 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.7 -0.8 -0.3 0.2
Age at first live birth 3.8 6.8 12.1 2.7 -3.5 -1.0
Pulse wave peak to peak time 0.3 0.4 0.7 -0.5 0.4 0.8
Health satisfaction 2.9 3.7 6.2 -1.7 2.5 -1.4
Shortness of breath walking on level ground 3.3 3.9 7.8 -1.9 2.8 -0.2
Qualifications: College or University degree 7.0 22.1 25.9 5.1 -4.2 -4.8
Eye problems/disorders: None of the above 0.5 0.6 1.4 -0.6 0.3 -1.2
Mouth/teeth dental problems: Loose teeth 0.7 0.9 1.8 0.7 0.5 -1.3
Emphysema/chronic bronchitis 4.6 5.1 5.7 -2.2 2.4 2.2
Medication for pain relief, constipation, heartburn 0.6 0.9 1.9 -0.9 -1.4 0.3
Neck or shoulder pain in last month 13.4 19.0 31.5 -4.4 5.6 2.4
Medication: Blood pressure 0.6 1.0 2.0 1.0 -1.4 0.0
Angina (self-reported) 0.0 0.0 0.0 -0.0 -0.2 -0.0
Migraine (self-reported) 0.6 0.8 1.8 1.3 -0.4 -0.6
Medication: Ibuprofen 0.8 1.0 2.2 1.5 0.5 -0.7
Medication: Allopurinol 1.3 1.8 4.2 1.0 -0.2 -2.0
Medication: Omeprazole 0.5 0.6 1.2 0.3 0.6 -1.1
Medication: Seretide 50 evohaler 0.2 0.3 0.4 -0.5 0.7 0.4
Mean time to correctly identify matches 0.3 0.5 1.1 -0.2 -0.6 -1.1
Heart disease (mother) 0.2 0.3 0.6 -0.3 -0.3 0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.2 -0.9 1.1 0.5
Whole body fat mass 1.3 5.5 10.4 -2.4 3.2 0.6
Leg fat mass (right) 1.2 4.7 8.8 -2.3 3.0 0.5
Arm predicted mass (right) 3.4 17.2 33.4 -4.2 5.8 0.5
Pulse rate, automated reading 1.3 4.3 6.4 -2.5 2.5 -0.6
Alcohol intake frequency. 5.9 13.6 25.1 -3.3 2.2 5.0
Comparative height size at age 10 2.5 13.8 31.6 -2.9 5.6 1.2
Number of full sisters 0.8 1.0 2.3 -1.5 0.7 0.5
Suffer from ‘nerves’ 0.3 0.4 1.3 0.1 1.1 0.1
Overall health rating 8.3 17.8 27.7 -5.0 5.3 0.8
Chest pain or discomfort 0.5 0.7 1.6 -0.7 0.1 -1.3
Had major operations 0.2 0.2 0.3 0.4 -0.6 0.3
Age at last live birth 1.7 2.5 4.4 2.1 -1.7 -0.2
Family relationship satisfaction 2.1 2.6 5.2 -1.5 2.3 0.6
Leg pain on walking 1.4 1.7 2.3 -1.4 1.5 -1.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.3 -0.4 0.2 -0.6
Commuting to job workplace: Car/motor vehicle 4.7 5.4 10.7 -2.2 3.3 -0.7
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.7 -1.0 0.1 1.6
Medication: Aspirin 2.5 3.4 6.2 2.5 -1.9 -0.5
Supplements: Vitamin C 0.5 0.6 1.9 0.0 0.2 1.4
Knee pain experienced in last month 4.4 6.8 11.1 -3.3 3.0 0.6
Hypertension (Self-reported) 2.0 5.6 9.0 2.8 -3.0 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.2 0.5 0.3 0.5
Illnesses of father: Heart disease 0.6 0.8 1.7 0.6 1.3 0.7
Illnesses of siblings: Diabetes 0.4 0.5 1.3 -0.4 0.1 -1.2
Smoking status: Previous 1.1 1.6 3.9 2.0 -0.8 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 1.9 -0.4 1.4 0.8
Whole body fat-free mass 2.2 12.7 27.5 -3.3 5.2 0.1
Leg fat-free mass (right) 1.5 7.9 18.3 -2.3 4.3 -0.2
Arm fat percentage (left) 0.2 0.8 1.7 -0.8 1.3 -0.3
Average weekly red wine intake 1.9 2.8 3.1 1.8 -1.7 -1.6
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.1 0.1 0.2 -0.1
Mood swings 1.5 2.7 6.4 -1.2 2.5 0.4
Loneliness, isolation 0.9 1.2 2.0 -1.0 1.4 0.8
Long-standing illness, disability or infirmity 0.4 0.6 0.9 -0.8 0.9 -0.5
Ever had bowel cancer screening 2.7 3.2 4.7 -2.2 1.7 1.4
Diabetes diagnosed by doctor 0.4 0.6 1.3 -0.4 -1.1 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 0.2 -0.6 0.1
Friendships satisfaction 1.0 1.3 1.9 0.1 1.4 -1.4
Qualifications: nursing, teaching 2.8 4.3 7.0 2.3 -2.7 -0.9
Commuting to job workplace: Walk 1.9 2.0 5.8 0.6 -2.4 -0.2
Eye problems/disorders: Cataract 1.2 1.4 2.0 1.1 -1.4 1.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.5 -0.0 1.2 0.5
Medication for cholesterol 1.5 2.3 3.6 -1.8 1.9 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.0 -1.0 -0.1 0.2
Back pain experienced in last month 8.7 12.7 17.8 -4.2 4.0 2.1
Mineral and other dietary supplements 4.1 5.5 14.3 -0.3 1.4 -3.8
Breast cancer (self-reported) 2.8 3.4 6.1 -2.0 2.5 -0.2
Asthma (self-reported) 0.1 0.1 0.4 -0.6 0.2 0.1
Osteoporosis (self-reported) 1.7 2.1 3.9 2.0 -1.2 -1.1
Osteoarthritis (self-reported) 0.8 1.1 2.3 -0.9 0.0 1.5
Medication: Aspirin 1.8 2.3 4.1 2.0 -1.7 -0.0
Medication: Gliclazide 0.6 0.7 1.4 -1.2 0.8 -0.0
Illnesses of father: None of the above (group 1) 1.2 1.4 3.3 1.0 -0.3 -1.8
Smoking status: Current 0.9 1.4 1.9 1.4 0.6 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.6 7.6 11.6 -3.4 2.7 2.0
Whole body water mass 2.2 12.7 27.7 -3.2 5.3 0.1
Leg predicted mass (right) 1.5 7.9 18.3 -2.3 4.3 -0.2
Arm fat mass (left) 1.2 5.0 10.3 -2.1 3.2 -0.1
Number of self-reported non-cancer illnesses 0.5 0.9 1.5 1.1 -1.2 -0.1
Average weekly champagne plus white wine intake 0.0 0.1 0.1 -0.0 -0.3 -0.3
Miserableness 0.4 0.7 0.9 0.8 0.7 -1.0
Guilty feelings 1.1 1.7 2.0 -1.3 1.4 1.1
Wears glasses or contact lenses 2.5 2.8 3.2 1.7 -1.8 -1.6
Ever taken oral contraceptive pill 1.9 2.1 4.1 1.5 -0.3 -2.0
Hearing aid user 0.9 1.0 2.9 -0.4 0.1 1.7
Mother’s age at death 0.6 0.7 1.3 -1.2 0.1 0.9
Financial situation satisfaction 1.0 1.2 1.4 1.2 1.0 -1.1
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.1 0.5 -0.1
Commuting to job workplace: Public transport 5.6 6.7 10.0 2.3 -3.2 -2.2
Eye problems/disorders: Glaucoma 2.8 3.4 9.6 -0.5 -0.5 3.1
Medication: Blood pressure 2.7 5.1 8.0 2.8 -2.7 -0.2
Pain type(s) experienced in last month: Hip pain 4.0 5.1 5.5 -2.3 2.3 2.1
Supplements: Fish oil (including cod liver oil) 2.7 3.5 9.9 0.2 -0.8 3.1
High cholesterol (Self-reported) 2.9 5.2 9.8 0.6 -3.1 2.3
Medication: Bendroflumethiazide 3.6 5.4 9.4 3.1 -2.3 -1.3
Medication: Paracetamol 0.8 1.3 2.4 -1.2 1.5 0.3
Medication: Lisinopril 1.7 2.2 3.9 1.6 -2.0 -0.5
Medication: Atorvastatin 4.6 5.7 10.4 2.6 -3.2 -0.4
Illnesses of father: High blood pressure 2.1 2.6 4.3 1.8 -2.1 -0.6
Alcohol drinker status: Never 1.3 1.5 2.8 0.2 -1.3 1.7
Ever smoked 2.9 5.0 9.7 2.3 -0.1 -3.1
Basal metabolic rate 2.2 12.3 26.5 -3.2 5.2 0.2
Leg fat percentage (left) 0.7 2.4 4.3 -1.7 2.1 0.0
Arm fat-free mass (left) 3.2 16.1 32.5 -4.0 5.7 0.3
Number of operations (self-reported) 0.9 1.4 3.2 -0.9 1.8 -0.4
Average weekly beer plus cider intake 0.8 1.2 2.6 -1.0 1.6 0.1
Irritability 2.1 3.5 7.1 -1.5 2.7 1.0
Risk taking 1.8 2.7 5.2 1.5 0.8 -2.3
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.9 -1.4 0.0 0.6
Fractured/broken bones in last 5 years 0.8 1.1 2.0 1.1 -0.0 -1.4
Age started oral contraceptive pill 1.3 1.6 2.5 1.2 -1.6 1.0
Diastolic blood pressure, automated reading 2.3 7.3 12.1 3.5 -2.8 -1.4
Ever depressed for a whole week 1.1 1.3 2.2 1.0 0.9 -1.5
Unable to work because of sickness or disability 0.9 1.2 2.4 -1.6 0.9 0.4
Commuting to job workplace: Cycle 0.8 1.0 1.2 1.1 -1.0 0.8
Myopia 0.1 0.2 0.3 -0.6 0.3 0.2
Vascular/heart problems diagnosed by doctor 2.3 6.4 11.0 -2.8 3.3 0.3
Cholesterol lowering medication 1.8 2.6 4.5 -0.4 -2.1 1.8
Medication: Omeprazole (e.g. Zanprol) 0.0 0.0 0.0 0.1 0.2 0.1
Pain experienced in last month 11.7 19.5 33.1 4.9 -5.8 -1.3
Supplements: Calcium 1.4 1.5 2.8 1.7 -1.3 -0.3
Basal cell carcinoma (self-reported) 1.5 1.8 4.2 -0.8 -0.8 2.1
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.5 1.0 -1.6 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.0 -0.0 1.0 -0.0
Heart disease (siblings) 2.7 3.3 5.2 -2.3 1.0 2.0
Alcohol drinker status: Previous 0.5 0.6 1.0 -0.3 1.0 0.8
Pack years of smoking 0.7 1.0 1.7 1.2 0.2 -1.3
Impedance of whole body 0.6 3.1 5.6 1.4 -2.4 1.3
Leg fat mass (left) 1.4 5.5 10.4 -2.4 3.2 0.3
Arm predicted mass (left) 3.1 15.5 30.8 -4.0 5.5 0.2