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chr17:42,041,273-43,913,030

Best TWAS P=2.37e-14 · Best GWAS P=1.4e-16 conditioned to 0.136

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	GTEx	Thyroid	ACBD4	0.20	0.16	enet	23	0.15	1.2e-11	-6.4	-7.6	2.4e-14	0.51	1.00	0.00	TRUE
6	GTEx	Artery Coronary	NMT1	0.13	0.06	enet	7	0.11	1.5e-04	5.2	-6.4	1.5e-10	0.53	0.13	0.20	TRUE
56	The Cancer Genome Atlas	Thyroid Carcinoma	HEXIM1	0.05	0.05	blup	47	0.04	8.5e-05	-8.3	7.5	8.0e-14	-0.84	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	ACBD4	0.10	0.06	enet	8	0.06	1.8e-05	-6.4	-7.3	3.0e-13	0.52	0.52	0.36	FALSE
31	GTEx	Nerve Tibial	ACBD4	0.21	0.10	lasso	5	0.11	4.2e-08	-6.1	-7.3	3.5e-13	0.47	0.92	0.07	FALSE
5	GTEx	Artery Aorta	DCAKD	0.22	0.16	enet	26	0.19	1.1e-10	-4.6	7.2	5.7e-13	-0.46	0.92	0.07	FALSE
34	GTEx	Skin Sun Exposed Lower leg	ACBD4	0.06	0.05	lasso	4	0.02	3.8e-03	5.7	-7.2	7.1e-13	0.33	0.19	0.08	FALSE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NMT1	0.23	0.08	blup	82	0.12	1.1e-05	4.6	-6.8	1.2e-11	0.55	0.06	0.87	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DCAKD	0.07	0.07	lasso	4	0.07	1.4e-08	-5.8	6.8	1.3e-11	-0.56	0.00	1.00	FALSE
35	GTEx	Stomach	DCAKD	0.29	0.17	enet	25	0.20	9.4e-10	-4.6	6.7	2.8e-11	-0.48	0.57	0.43	FALSE
41	YFS	Blood	NMT1	0.02	0.01	lasso	6	0.01	5.0e-03	5.8	-6.6	3.7e-11	0.37	0.29	0.02	FALSE
9	GTEx	Artery Tibial	ACBD4	0.10	0.09	lasso	2	0.08	4.8e-07	-6.5	-6.5	9.3e-11	0.58	0.80	0.13	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACBD4	0.08	0.04	enet	9	0.04	6.9e-06	-6.4	-6.3	3.2e-10	0.50	0.95	0.01	FALSE
21	GTEx	Esophagus Gastroesophageal Junction	NMT1	0.24	0.21	lasso	4	0.22	2.8e-08	4.2	-6.3	3.5e-10	0.54	0.72	0.22	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	DCAKD	0.30	0.21	lasso	6	0.20	5.0e-11	-5.8	6.3	3.9e-10	-0.58	1.00	0.00	FALSE
12	GTEx	Brain Cerebellar Hemisphere	CTD-2020K17.4	0.23	0.02	enet	20	0.11	1.1e-03	-6.0	-6.2	6.4e-10	0.46	0.03	0.16	FALSE
58	The Cancer Genome Atlas	Thyroid Carcinoma	PLCD3	0.24	0.16	lasso	5	0.20	2.8e-19	5.5	6.2	6.4e-10	-0.15	1.00	0.00	FALSE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	ACBD4	0.04	0.01	enet	7	0.03	2.2e-04	3.8	-6.2	7.0e-10	0.44	0.09	0.13	FALSE
29	GTEx	Muscle Skeletal	DCAKD	0.12	0.06	enet	16	0.07	9.9e-08	-5.8	6.1	9.0e-10	-0.54	0.86	0.14	FALSE
1	GTEx	Adipose Subcutaneous	DCAKD	0.21	0.09	lasso	6	0.14	6.1e-12	5.3	6.1	1.0e-09	-0.35	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	NMT1	0.04	0.00	blup	81	0.01	1.9e-02	-4.7	-6.0	1.8e-09	0.27	0.03	0.62	FALSE
17	GTEx	Breast Mammary Tissue (Male)	DCAKD	0.36	0.29	lasso	8	0.33	1.4e-08	-4.6	6.0	2.3e-09	-0.58	0.41	0.44	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	DCAKD	0.42	0.36	lasso	7	0.37	3.8e-14	-5.8	6.0	2.7e-09	-0.58	0.96	0.04	FALSE
24	GTEx	Esophagus Mucosa	ACBD4	0.14	0.10	lasso	4	0.10	4.5e-07	5.5	-5.9	3.4e-09	0.13	0.59	0.08	FALSE
13	GTEx	Brain Cerebellum	DCAKD	0.40	0.06	enet	20	0.24	1.4e-07	-4.6	5.8	5.0e-09	-0.39	0.80	0.06	FALSE
7	GTEx	Artery Tibial	NMT1	0.11	0.09	lasso	5	0.10	6.3e-08	-4.9	-5.8	5.4e-09	0.36	0.99	0.00	FALSE
26	GTEx	Heart Left Ventricle	DCAKD	0.17	0.17	lasso	3	0.17	2.3e-09	-4.6	5.8	6.0e-09	-0.55	0.96	0.03	FALSE
53	The Cancer Genome Atlas	Prostate Adenocarcinoma	LOC644172	0.15	0.01	blup	77	0.06	1.0e-06	5.8	5.8	6.6e-09	-0.40	0.19	0.29	FALSE
28	GTEx	Muscle Skeletal	PLCD3	0.18	0.10	enet	8	0.10	1.7e-10	5.5	5.8	8.2e-09	-0.12	1.00	0.00	FALSE
40	YFS	Blood	HEXIM2	0.02	0.01	bslmm	279	0.01	1.0e-05	5.2	-5.8	8.5e-09	0.61	0.66	0.29	FALSE
20	GTEx	Colon Transverse	DCAKD	0.28	0.18	lasso	8	0.26	1.5e-12	-4.6	5.7	1.2e-08	-0.41	0.99	0.01	FALSE
23	GTEx	Esophagus Mucosa	DCAKD	0.33	0.32	enet	20	0.35	5.6e-24	-4.6	5.7	1.2e-08	-0.51	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	PLCD3	0.04	0.01	blup	64	0.01	2.3e-02	5.5	-5.7	1.2e-08	0.27	0.05	0.08	FALSE
14	GTEx	Brain Cerebellum	ACBD4	0.40	0.06	lasso	8	0.17	1.0e-05	5.7	-5.7	1.3e-08	0.27	0.09	0.14	FALSE
16	GTEx	Breast Mammary Tissue	DCAKD	0.16	0.13	lasso	7	0.13	2.9e-07	-5.8	5.7	1.4e-08	-0.59	0.92	0.08	FALSE
33	GTEx	Skin Sun Exposed Lower leg	DCAKD	0.33	0.20	enet	30	0.31	2.4e-26	-4.6	5.6	1.9e-08	-0.27	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LOC644172	0.19	-0.01	blup	81	0.03	1.3e-02	1.8	5.6	2.1e-08	-0.47	0.02	0.56	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	NMT1	0.08	0.04	blup	83	0.05	3.5e-06	-4.6	-5.6	2.4e-08	0.37	0.86	0.12	FALSE
4	GTEx	Artery Aorta	NMT1	0.14	0.08	lasso	2	0.12	3.9e-07	-4.7	-5.5	3.1e-08	0.50	0.94	0.02	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC644172	0.04	0.00	enet	15	0.02	4.0e-03	-8.3	5.5	3.2e-08	-0.60	0.00	0.76	FALSE
36	GTEx	Thyroid	DCAKD	0.25	0.26	enet	17	0.27	9.4e-21	-5.8	5.5	3.4e-08	-0.57	1.00	0.00	FALSE
3	GTEx	Adrenal Gland	PLEKHM1	0.21	0.00	enet	20	0.08	1.0e-03	3.8	5.5	4.4e-08	-0.13	0.08	0.13	FALSE
11	GTEx	Brain Cerebellar Hemisphere	ACBD4	0.43	0.12	lasso	8	0.18	1.7e-05	-6.1	-5.5	4.6e-08	0.37	0.11	0.44	FALSE
8	GTEx	Artery Tibial	DCAKD	0.27	0.21	lasso	8	0.20	6.6e-16	-4.6	5.4	5.6e-08	-0.43	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Thyroid Carcinoma	NMT1	0.18	0.19	enet	20	0.20	3.8e-19	-4.7	-5.4	6.8e-08	0.40	1.00	0.00	FALSE
55	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC644172	0.20	0.01	enet	12	0.06	4.5e-03	-3.5	5.4	8.4e-08	-0.47	0.06	0.09	FALSE
18	GTEx	Cells Transformed fibroblasts	PLCD3	0.23	0.04	lasso	5	0.08	1.3e-06	2.3	5.3	8.6e-08	-0.48	0.95	0.01	FALSE
30	GTEx	Nerve Tibial	DCAKD	0.35	0.29	enet	21	0.30	1.6e-21	4.6	5.3	8.7e-08	-0.42	1.00	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	HEXIM1	0.11	0.10	lasso	2	0.08	1.6e-06	5.3	5.3	1.1e-07	-0.58	0.79	0.14	FALSE
25	GTEx	Esophagus Muscularis	DCAKD	0.27	0.29	lasso	5	0.30	2.1e-18	-4.6	5.3	1.1e-07	-0.47	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LOC644172	0.08	0.00	blup	79	0.04	3.2e-04	2.9	5.3	1.1e-07	-0.51	0.07	0.28	FALSE
54	The Cancer Genome Atlas	Prostate Adenocarcinoma	NMT1	0.09	0.08	lasso	3	0.09	1.1e-09	4.6	-5.3	1.1e-07	0.46	0.87	0.13	FALSE
27	GTEx	Lung	DCAKD	0.22	0.05	enet	27	0.10	5.2e-08	4.1	5.3	1.2e-07	-0.44	0.96	0.03	FALSE
10	GTEx	Artery Tibial	HEXIM1	0.13	0.08	lasso	2	0.05	1.8e-04	5.3	5.3	1.3e-07	-0.58	0.86	0.10	FALSE
39	METSIM	Adipose	C17orf104	0.05	0.02	bslmm	404	0.04	4.2e-06	4.4	-5.3	1.4e-07	0.11	0.91	0.00	FALSE
38	GTEx	Whole Blood	DCAKD	0.07	0.08	lasso	2	0.06	1.8e-06	-4.6	5.2	2.4e-07	-0.52	0.95	0.03	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DCAKD	0.04	0.02	blup	66	0.02	3.5e-03	-4.9	5.2	2.6e-07	-0.48	0.02	0.94	FALSE
15	GTEx	Brain Hippocampus	CCDC43	0.23	0.09	enet	9	0.16	1.8e-04	-6.1	5.1	2.9e-07	-0.46	0.05	0.30	FALSE