Best TWAS P=2.16e-13 · Best GWAS P=2.07e-09 conditioned to 9.94e-07
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TTLL6 | 0.23 | 0.12 | bslmm | 418 | 0.15 | 1.7e-17 | 1.1 | -6.1 | 1.1e-09 | -0.09 | 0.52 | 0.48 | FALSE |
2 | GTEx | Brain Cerebellum | CALCOCO2 | 0.25 | 0.08 | enet | 11 | 0.11 | 4.3e-04 | -4.6 | -5.3 | 1.3e-07 | 0.21 | 0.03 | 0.88 | FALSE |
3 | GTEx | Brain Nucleus accumbens basal ganglia | CDK5RAP3 | 0.21 | 0.04 | lasso | 4 | 0.02 | 7.2e-02 | 5.6 | -5.2 | 2.5e-07 | 0.06 | 0.03 | 0.75 | FALSE |
4 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-6N17.9 | 0.47 | 0.05 | lasso | 17 | 0.11 | 8.3e-04 | 4.9 | -5.5 | 3.7e-08 | -0.07 | 0.04 | 0.76 | TRUE |
5 | GTEx | Cells EBV-transformed lymphocytes | HOXB3 | 0.28 | 0.00 | lasso | 7 | 0.00 | 5.0e-01 | -4.2 | -6.2 | 7.8e-10 | 0.17 | 0.04 | 0.17 | FALSE |
6 | GTEx | Liver | SCRN2 | 0.32 | 0.05 | enet | 14 | 0.11 | 5.5e-04 | -4.9 | 5.8 | 5.0e-09 | -0.29 | 0.09 | 0.60 | TRUE |
7 | GTEx | Stomach | RP11-6N17.9 | 0.13 | 0.02 | lasso | 6 | 0.04 | 8.0e-03 | 4.6 | -5.1 | 2.7e-07 | 0.15 | 0.06 | 0.83 | FALSE |
8 | GTEx | Testis | RP11-6N17.4 | 0.14 | 0.02 | lasso | 10 | 0.02 | 4.8e-02 | 5.5 | 5.2 | 1.5e-07 | -0.06 | 0.04 | 0.92 | FALSE |
9 | YFS | Blood | UBE2Z | 0.06 | 0.03 | enet | 19 | 0.06 | 1.5e-18 | 2.5 | 6.3 | 3.4e-10 | -0.06 | 0.32 | 0.68 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | ATP5G1 | 0.04 | 0.01 | enet | 6 | 0.03 | 5.4e-05 | 4.9 | 6.4 | 1.3e-10 | -0.17 | 0.04 | 0.84 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | CALCOCO2 | 0.04 | 0.03 | blup | 50 | 0.02 | 1.6e-03 | -4.2 | 7.3 | 2.2e-13 | -0.04 | 0.02 | 0.21 | TRUE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CALCOCO2 | 0.08 | 0.03 | blup | 50 | 0.07 | 1.4e-07 | -4.2 | 6.8 | 1.5e-11 | -0.19 | 0.03 | 0.97 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CBX1 | 0.03 | 0.04 | lasso | 4 | 0.04 | 3.7e-05 | 5.5 | -5.5 | 2.9e-08 | 0.05 | 0.02 | 0.96 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | MRPL10 | 0.07 | 0.00 | blup | 59 | 0.02 | 8.7e-03 | -4.9 | -5.4 | 5.5e-08 | 0.27 | 0.00 | 0.56 | FALSE |