Best TWAS P=1.08e-09 · Best GWAS P=4.04e-08 conditioned to 0.0502
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FEZ2 | 0.16 | 0.24 | lasso | 2 | 0.22 | 1.3e-26 | 5.4 | -5.4 | 6.7e-08 | -0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | AC007401.1 | 0.10 | 0.02 | lasso | 4 | 0.02 | 5.4e-03 | 4.9 | 5.5 | 3.1e-08 | 0.87 | 0.02 | 0.94 | FALSE |
| 3 | GTEx | Artery Tibial | CRIM1 | 0.10 | 0.04 | lasso | 4 | 0.05 | 1.4e-04 | 4.9 | -5.4 | 6.6e-08 | -0.86 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Spleen | FEZ2 | 0.42 | 0.16 | enet | 25 | 0.17 | 3.9e-05 | 4.6 | 6.1 | 1.1e-09 | 0.66 | 0.04 | 0.86 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FEZ2 | 0.01 | 0.01 | blup | 85 | 0.01 | 1.0e-03 | 4.5 | -5.2 | 1.5e-07 | -0.90 | 0.01 | 0.96 | FALSE |