[Hub]/) : Traits : Arm fat-free mass (right) : ← →

chr2:23,453,834-29,344,127

Best TWAS P=7.89e-41 · Best GWAS P=2.29e-38 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
81	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FNDC4	0.13	0.06	lasso	2	0.05	1.1e-03	-12.95	13.4	7.9e-41	-0.99	0.00	0.96	TRUE
88	The Cancer Genome Atlas	Thyroid Carcinoma	GCKR	0.18	0.08	enet	5	0.13	1.7e-12	7.67	10.3	1.2e-24	-0.64	0.91	0.09	TRUE
45	GTEx	Spleen	UBXN2A	0.31	0.11	enet	19	0.17	4.1e-05	7.99	-7.9	2.7e-15	-0.05	0.04	0.92	TRUE
51	GTEx	Thyroid	RP11-373D23.3	0.16	0.07	enet	19	0.04	2.6e-04	4.80	-6.9	4.0e-12	0.15	0.52	0.13	TRUE
26	GTEx	Esophagus Gastroesophageal Junction	AC074117.10	0.12	0.13	enet	9	0.09	4.9e-04	5.19	-6.6	3.2e-11	0.64	0.43	0.30	TRUE
36	GTEx	Lung	NCOA1	0.12	0.04	lasso	7	0.06	1.9e-05	-3.67	-6.4	1.3e-10	0.01	0.52	0.02	TRUE
21	GTEx	Colon Sigmoid	DNMT3A	0.19	-0.01	lasso	8	0.00	4.5e-01	-1.52	-6.3	3.5e-10	0.06	0.07	0.12	TRUE
76	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBP1	0.15	0.10	lasso	2	0.10	5.8e-04	6.19	-6.3	3.8e-10	0.67	0.02	0.09	TRUE
37	GTEx	Lung	RP11-373D23.3	0.08	0.00	enet	21	0.02	2.3e-02	3.77	-6.1	8.2e-10	0.23	0.15	0.33	TRUE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBP1	0.03	0.03	blup	30	0.03	2.2e-04	4.39	-5.9	4.5e-09	0.64	0.67	0.08	TRUE
63	ROSMAP	Brain Pre-frontal Cortex	KCNK3	0.24	0.15	lasso	3	0.15	6.5e-19	5.24	-5.7	1.6e-08	0.09	0.01	0.99	TRUE
75	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SUPT7L	0.06	0.03	blup	29	0.05	2.0e-03	7.97	5.5	3.2e-08	-0.04	0.04	0.04	TRUE
68	YFS	Blood	MRPL33	0.02	0.01	blup	385	0.01	6.4e-05	5.93	-5.5	4.4e-08	0.22	0.97	0.00	TRUE
34	GTEx	Heart Atrial Appendage	PFN4	0.22	0.06	lasso	7	0.10	2.8e-05	1.26	-5.4	5.7e-08	0.12	0.64	0.06	TRUE
49	GTEx	Thyroid	FNDC4	0.24	0.10	enet	23	0.16	2.2e-12	7.67	10.8	3.5e-27	-0.69	0.67	0.33	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	FNDC4	0.24	0.09	enet	9	0.17	1.9e-16	7.89	10.8	5.1e-27	-0.70	0.41	0.59	FALSE
80	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SUPT7L	0.05	0.02	blup	28	0.04	5.2e-05	8.06	10.2	1.6e-24	-0.40	0.19	0.14	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	IFT172	0.08	0.01	blup	43	0.02	6.1e-03	8.62	10.1	3.7e-24	-0.54	0.02	0.27	FALSE
48	GTEx	Testis	AC074117.10	0.14	0.08	lasso	6	0.12	4.5e-06	5.23	-9.5	1.7e-21	0.85	0.05	0.94	FALSE
73	The Cancer Genome Atlas	Breast Invasive Carcinoma	GPN1	0.06	0.02	lasso	6	0.02	7.2e-05	-9.97	-8.5	2.0e-17	0.54	0.00	0.99	FALSE
47	GTEx	Testis	NRBP1	0.16	0.09	lasso	3	0.06	1.8e-03	6.19	-8.5	2.4e-17	0.80	0.03	0.96	FALSE
31	GTEx	Esophagus Muscularis	NRBP1	0.07	0.04	lasso	6	0.04	1.3e-03	6.19	-8.4	3.8e-17	0.82	0.01	0.97	FALSE
29	GTEx	Esophagus Mucosa	AC074117.10	0.12	0.14	lasso	8	0.14	2.1e-09	6.19	-8.2	3.3e-16	0.74	0.94	0.06	FALSE
46	GTEx	Stomach	AC074117.10	0.06	0.01	lasso	7	0.01	7.8e-02	6.19	8.1	6.1e-16	-0.36	0.20	0.08	FALSE
41	GTEx	Ovary	AC074117.10	0.16	0.04	enet	9	0.05	2.0e-02	5.15	-8.0	1.1e-15	0.77	0.04	0.80	FALSE
61	ROSMAP	Brain Pre-frontal Cortex	IFT172	0.07	0.02	blup	287	0.03	5.8e-05	5.79	7.5	6.5e-14	-0.63	0.43	0.49	FALSE
52	GTEx	Vagina	AC074117.10	0.14	0.04	enet	13	0.06	1.4e-02	4.39	-7.4	1.0e-13	0.72	0.08	0.57	FALSE
2	CommonMind	Brain Pre-frontal Cortex	IFT172	0.06	0.09	enet	16	0.09	3.9e-11	4.96	7.3	1.9e-13	-0.75	0.48	0.52	FALSE
15	GTEx	Breast Mammary Tissue (Female)	AC074117.10	0.06	0.01	lasso	2	0.04	2.7e-02	6.57	7.3	3.7e-13	-0.23	0.04	0.05	FALSE
1	CommonMind	Brain Pre-frontal Cortex	GTF3C2	0.06	0.09	lasso	8	0.08	7.2e-10	4.88	-7.1	1.2e-12	0.72	0.28	0.72	FALSE
24	GTEx	Colon Transverse	UBXN2A	0.11	0.01	enet	8	0.03	8.7e-03	-6.49	-7.0	1.7e-12	-0.06	0.08	0.68	FALSE
33	GTEx	Heart Atrial Appendage	UBXN2A	0.08	0.02	lasso	3	0.02	5.2e-02	-6.13	-6.8	9.9e-12	0.02	0.23	0.28	FALSE
28	GTEx	Esophagus Mucosa	TP53I3	0.16	0.03	enet	23	0.06	8.2e-05	1.26	-6.8	1.5e-11	0.05	0.11	0.10	FALSE
56	METSIM	Adipose	NRBP1	0.06	0.09	lasso	3	0.08	1.6e-12	6.19	-6.6	3.8e-11	0.67	1.00	0.00	FALSE
32	GTEx	Esophagus Muscularis	AC074117.10	0.17	0.14	enet	5	0.09	6.6e-06	6.19	-6.5	6.7e-11	0.65	0.73	0.26	FALSE
4	GTEx	Adipose Subcutaneous	AC074117.10	0.06	0.04	lasso	5	0.02	4.8e-03	6.19	-6.5	6.9e-11	0.65	0.45	0.27	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	UBXN2A	0.03	0.01	lasso	4	0.02	2.2e-03	-6.08	6.4	1.2e-10	-0.04	0.35	0.02	FALSE
30	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	-3.43	-6.4	1.4e-10	0.01	0.06	0.28	FALSE
65	ROSMAP	Brain Pre-frontal Cortex	FTH1P3	0.04	0.01	bslmm	280	0.02	2.8e-03	6.19	-6.4	1.5e-10	0.65	0.04	0.70	FALSE
74	The Cancer Genome Atlas	Breast Invasive Carcinoma	SNX17	0.08	0.01	blup	25	0.02	6.6e-05	2.71	6.4	2.0e-10	-0.55	0.02	0.34	FALSE
18	GTEx	Cells Transformed fibroblasts	NRBP1	0.09	0.08	lasso	3	0.08	7.8e-07	5.79	-6.2	5.0e-10	0.61	0.95	0.04	FALSE
39	GTEx	Muscle Skeletal	GPN1	0.06	0.02	enet	9	0.02	2.9e-03	-2.17	-6.2	5.6e-10	0.43	0.29	0.07	FALSE
40	GTEx	Nerve Tibial	NRBP1	0.06	0.00	enet	9	0.02	2.0e-02	6.19	-6.2	5.7e-10	0.61	0.28	0.61	FALSE
69	YFS	Blood	NRBP1	0.01	0.01	lasso	6	0.01	9.1e-06	5.23	-6.2	5.9e-10	0.61	0.99	0.00	FALSE
11	GTEx	Artery Tibial	PPM1G	0.06	0.02	lasso	4	0.03	2.3e-03	4.79	-6.2	6.3e-10	0.66	0.29	0.12	FALSE
71	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPM1G	0.03	0.02	blup	31	0.02	8.8e-03	5.08	-6.1	8.0e-10	0.66	0.03	0.51	FALSE
82	The Cancer Genome Atlas	Brain Lower Grade Glioma	UBXN2A	0.04	0.04	lasso	1	0.03	1.4e-04	-6.07	6.1	1.3e-09	-0.03	0.36	0.14	FALSE
3	CommonMind	Brain Pre-frontal Cortex	UBXN2A	0.22	0.18	enet	28	0.24	3.0e-28	-7.11	6.0	1.7e-09	-0.03	1.00	0.00	FALSE
12	GTEx	Artery Tibial	AC074117.10	0.13	0.14	lasso	5	0.13	1.1e-10	5.79	-6.0	1.8e-09	0.62	0.99	0.00	FALSE
55	METSIM	Adipose	KRTCAP3	0.05	0.01	blup	288	0.03	1.6e-05	4.98	6.0	2.1e-09	-0.52	0.96	0.03	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	RP11-373D23.3	0.17	0.01	enet	15	0.04	1.2e-02	5.23	-5.9	2.9e-09	0.28	0.07	0.30	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	PFN4	0.18	0.13	lasso	12	0.12	8.9e-05	-4.54	-5.9	3.2e-09	0.06	0.32	0.09	FALSE
20	GTEx	Cells Transformed fibroblasts	AC074117.10	0.21	0.19	enet	23	0.18	1.6e-13	6.19	-5.8	6.5e-09	0.66	0.87	0.13	FALSE
10	GTEx	Artery Aorta	AC074117.10	0.06	0.04	lasso	3	0.03	6.8e-03	5.79	-5.8	8.2e-09	0.58	0.24	0.14	FALSE
35	GTEx	Heart Left Ventricle	PFN4	0.23	0.28	lasso	6	0.28	4.1e-15	-4.53	-5.7	1.0e-08	0.05	1.00	0.00	FALSE
44	GTEx	Small Intestine Terminal Ileum	UBXN2A	0.18	0.08	enet	33	0.16	2.5e-04	-6.54	-5.7	1.0e-08	-0.08	0.03	0.89	FALSE
6	GTEx	Adipose Visceral Omentum	PPM1G	0.06	0.01	lasso	5	0.01	1.1e-01	5.15	-5.7	1.5e-08	0.64	0.11	0.28	FALSE
22	GTEx	Colon Sigmoid	AC074117.10	0.13	0.18	lasso	3	0.14	1.1e-05	5.79	-5.6	1.7e-08	0.60	0.85	0.08	FALSE
7	GTEx	Adipose Visceral Omentum	AC074117.10	0.14	0.09	lasso	3	0.08	5.0e-05	5.79	-5.6	2.2e-08	0.60	0.85	0.08	FALSE
72	The Cancer Genome Atlas	Breast Invasive Carcinoma	FKBP1B	0.04	0.02	blup	41	0.02	3.6e-05	-4.54	5.6	2.2e-08	-0.08	0.43	0.06	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	NRBP1	0.11	0.13	enet	13	0.15	1.2e-05	5.04	-5.6	2.5e-08	0.62	0.57	0.10	FALSE
57	METSIM	Adipose	PREB	0.04	0.01	bslmm	302	0.02	5.6e-04	3.23	5.5	2.9e-08	-0.36	0.07	0.30	FALSE
90	The Cancer Genome Atlas	Thyroid Carcinoma	NRBP1	0.03	0.01	blup	30	0.02	5.3e-03	6.19	-5.5	3.9e-08	0.62	0.32	0.05	FALSE
53	GTEx	Whole Blood	UBXN2A	0.17	0.07	lasso	8	0.09	2.1e-08	-1.06	-5.5	4.2e-08	-0.08	0.04	0.96	FALSE
43	GTEx	Skin Sun Exposed Lower leg	SLC4A1AP	0.04	0.01	lasso	3	0.02	1.7e-02	5.00	5.5	4.4e-08	-0.60	0.21	0.11	FALSE
66	YFS	Blood	EIF2B4	0.01	0.00	enet	9	0.00	8.5e-02	2.35	5.5	4.4e-08	-0.52	0.04	0.03	FALSE
78	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC4A1AP	0.02	0.03	lasso	2	0.03	3.7e-04	-1.50	5.4	5.3e-08	-0.47	0.01	0.83	FALSE
50	GTEx	Thyroid	AC074117.10	0.17	0.14	lasso	4	0.15	2.7e-11	5.19	-5.4	5.4e-08	0.61	1.00	0.00	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	PFN4	0.13	0.01	lasso	12	0.01	9.7e-02	-5.81	-5.4	7.0e-08	0.08	0.11	0.06	FALSE
42	GTEx	Pituitary	AC074117.10	0.23	0.23	lasso	8	0.29	5.6e-08	4.25	-5.4	7.4e-08	0.66	0.34	0.57	FALSE
23	GTEx	Colon Transverse	NRBP1	0.08	0.03	enet	14	0.00	2.0e-01	5.45	-5.4	7.9e-08	0.59	0.16	0.14	FALSE
38	GTEx	Muscle Skeletal	SNX17	0.18	0.24	lasso	6	0.26	6.2e-26	5.29	-5.3	9.1e-08	0.61	1.00	0.00	FALSE
59	METSIM	Adipose	UBXN2A	0.07	0.03	bslmm	403	0.06	5.3e-10	-6.42	-5.3	1.0e-07	0.00	0.89	0.10	FALSE
19	GTEx	Cells Transformed fibroblasts	IFT172	0.04	0.04	lasso	2	0.02	8.1e-03	5.32	5.3	1.2e-07	-0.60	0.20	0.25	FALSE
54	METSIM	Adipose	BRE	0.03	0.00	blup	534	0.00	1.3e-01	-0.18	-5.3	1.2e-07	0.30	0.10	0.05	FALSE
58	METSIM	Adipose	SLC5A6	0.03	0.02	bslmm	298	0.01	3.9e-03	2.74	-5.3	1.2e-07	0.43	0.25	0.04	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	PPM1G	0.03	0.02	blup	32	0.02	2.4e-03	5.03	-5.3	1.3e-07	0.61	0.16	0.05	FALSE
86	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SLC4A1AP	0.17	0.05	blup	26	0.08	4.4e-03	-9.97	5.3	1.3e-07	-0.47	0.01	0.72	FALSE
62	ROSMAP	Brain Pre-frontal Cortex	KRTCAP3	0.06	0.05	blup	279	0.05	3.1e-07	5.15	5.2	1.7e-07	-0.58	0.99	0.00	FALSE
14	GTEx	Brain Cortex	KRTCAP3	0.19	0.10	lasso	2	0.12	3.7e-04	4.39	5.2	1.8e-07	-0.54	0.24	0.35	FALSE
5	GTEx	Adipose Visceral Omentum	NRBP1	0.05	0.05	lasso	4	0.04	2.5e-03	5.15	-5.2	2.0e-07	0.61	0.34	0.07	FALSE
13	GTEx	Brain Cerebellum	AC074117.10	0.13	0.08	enet	6	0.07	4.4e-03	5.08	5.2	2.0e-07	-0.60	0.09	0.48	FALSE
60	ROSMAP	Brain Pre-frontal Cortex	SNX17	0.27	0.35	lasso	10	0.34	7.9e-46	5.12	5.2	2.0e-07	-0.60	1.00	0.00	FALSE
9	GTEx	Artery Aorta	NCOA1	0.15	0.00	enet	15	0.01	1.4e-01	-2.87	-5.2	2.1e-07	-0.01	0.07	0.04	FALSE
8	GTEx	Adrenal Gland	KRTCAP3	0.11	0.16	lasso	4	0.15	4.9e-06	5.04	5.2	2.2e-07	-0.60	0.54	0.38	FALSE
77	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IFT172	0.02	0.01	blup	43	0.02	2.7e-03	4.49	-5.2	2.2e-07	0.60	0.10	0.10	FALSE
79	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SNX17	0.02	0.01	blup	26	0.01	2.1e-02	5.14	5.2	2.2e-07	-0.62	0.13	0.18	FALSE
67	YFS	Blood	KRTCAP3	0.12	0.18	bslmm	286	0.18	1.0e-55	4.96	5.1	2.7e-07	-0.59	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-4.33	-5.1	2.9e-07	0.01	0.00	0.60	FALSE
70	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NRBP1	0.05	0.06	lasso	2	0.05	6.0e-05	5.12	-5.1	3.0e-07	0.60	0.82	0.01	FALSE