Hub : Genes

FEZ2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1590 0.0330 2.8e-16 0.237 0.138 0.199 0.215 0.222 1.7e-28 1.6e-16 9.2e-24 9.8e-26 1.3e-26
2 GTEx Brain Cerebellar Hemisphere 0.4070 0.0940 6.1e-05 0.295 NA 0.086 NA 0.276 2.7e-08 NA 3.2e-03 NA 8.6e-08
3 GTEx Brain Cerebellum 0.4360 0.0920 4.3e-06 0.260 NA 0.170 NA 0.226 2.7e-08 NA 9.8e-06 NA 2.6e-07
4 GTEx Spleen 0.4170 0.0950 3.1e-05 0.162 NA 0.170 NA 0.100 5.9e-05 NA 3.8e-05 NA 1.6e-03
5 GTEx Whole Blood 0.1130 0.0310 1.1e-06 0.094 NA 0.104 NA 0.081 5.9e-09 NA 8.4e-10 NA 6.0e-08
6 NTR Blood 0.0164 0.0070 6.6e-03 0.000 0.002 -0.001 0.004 0.002 4.2e-01 5.2e-02 9.7e-01 1.9e-02 5.9e-02
7 ROSMAP Brain Pre-frontal Cortex 0.4123 0.0436 0.0e+00 0.549 0.496 0.579 0.572 0.585 1.1e-84 3.2e-73 7.3e-92 4.5e-90 3.1e-93
8 YFS Blood 0.4005 0.0332 0.0e+00 0.515 0.511 0.537 0.551 0.537 7.3e-201 3.6e-198 3.1e-213 7.7e-222 1.7e-213
9 TCGA Breast Invasive Carcinoma 0.0140 0.0079 1.1e-03 0.008 0.013 0.006 NA 0.006 6.4e-03 1.0e-03 1.5e-02 NA 1.4e-02
10 TCGA Cervical Squamous Cell Carcinoma 0.0620 0.0370 3.1e-03 0.054 0.043 0.042 NA 0.044 1.1e-03 3.5e-03 3.7e-03 NA 3.3e-03
11 TCGA Colon Adenocarcinoma 0.1100 0.0640 9.6e-05 0.034 0.071 0.058 NA 0.035 4.7e-03 6.1e-05 2.7e-04 NA 4.0e-03
12 TCGA Esophageal Carcinoma 0.1090 0.0590 7.3e-03 0.011 0.021 -0.007 NA -0.002 1.4e-01 7.1e-02 6.5e-01 NA 3.8e-01
13 TCGA Head and Neck Squamous Cell Carcinoma 0.0434 0.0256 2.2e-03 0.004 0.016 0.008 NA 0.006 1.1e-01 6.1e-03 4.2e-02 NA 6.6e-02
14 TCGA Brain Lower Grade Glioma 0.0770 0.0541 1.0e-03 0.013 0.024 0.025 NA 0.013 1.0e-02 7.8e-04 6.5e-04 NA 1.2e-02
15 TCGA Prostate Adenocarcinoma 0.0637 0.0262 9.3e-09 0.050 0.078 0.071 NA 0.070 6.2e-06 1.4e-08 7.1e-08 NA 7.8e-08
16 TCGA Testicular Germ Cell Tumors 0.1830 0.0700 1.8e-05 0.207 0.178 0.198 NA 0.211 7.6e-08 7.1e-07 1.5e-07 NA 5.3e-08
17 TCGA Thyroid Carcinoma 0.0720 0.0350 2.3e-05 0.059 0.058 0.058 NA 0.056 2.0e-06 2.4e-06 2.7e-06 NA 3.8e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.1 0.2 0.8 0.9 -0.0 -0.1 -0.1 -0.4 0.1 0.4 0.4 0.4 0.6 0.5 -0.0 -0.1 0.0 0.4 0.9 -0.5
Bipolar Disorder or Schizophrenia 0.3 0.7 3.3 0.8 -0.7 -1.0 -1.8 -1.5 -0.4 0.5 -0.3 1.1 0.4 0.7 0.5 0.3 0.1 1.0 0.7 0.6
Depressed Affect (Nagel 2018) 0.3 0.6 3.5 -1.0 -0.1 -0.5 1.0 -0.6 -1.9 -0.1 -0.8 -0.7 0.1 0.3 0.3 -0.1 0.9 -0.1 -1.0 0.5
Depression (Nagel 2018) 0.6 0.9 2.7 0.6 -0.4 -1.0 -0.3 -1.4 -1.6 0.9 -0.9 0.3 1.4 1.1 0.5 0.2 1.1 1.0 1.1 0.3
Intelligence (Savage-Jansen 2018) 0.2 0.6 3.7 -0.9 0.4 0.0 -0.1 0.2 0.7 -0.9 0.6 -1.2 -1.0 -0.2 -0.3 -0.8 0.3 -0.5 -1.9 -0.7
Neuroticism (Nagel 2018) 0.1 0.3 2.4 -0.7 0.2 0.1 1.0 -0.2 -1.6 -0.1 -0.7 -0.7 0.1 0.2 0.1 -0.3 0.5 -0.2 -0.6 0.2
Schizophrenia (2018) 0.4 0.9 5.0 0.4 -0.8 -1.3 -2.2 -1.5 -0.5 0.4 -0.7 1.1 0.0 0.5 0.7 0.5 0.1 1.0 0.2 1.1
Schizophrenia vs Biploar Disorder 1.0 1.3 3.0 0.8 -1.3 -1.6 -1.1 -1.6 -0.3 0.8 -1.0 1.6 0.5 1.0 1.5 1.2 0.4 1.2 0.4 1.7
Worry (Nagel 2018) 0.4 0.8 6.3 0.4 -0.2 -0.2 0.0 -0.4 -2.5 0.7 -1.2 0.0 1.1 1.2 0.4 0.6 1.1 0.7 0.2 0.2
Alzheimer’s Disease (in mother) 0.5 0.6 1.7 -0.5 0.7 1.3 0.7 0.8 1.0 -0.6 0.6 -0.5 -0.5 -0.7 -0.5 -0.7 -1.1 -0.8 0.5 -0.8
Alzheimer’s Disease (in father) 0.6 0.6 3.5 1.2 -0.3 0.1 -1.2 -0.3 -0.1 0.7 -0.1 0.9 1.0 1.0 0.2 0.2 -0.2 0.8 1.9 0.0
Alzheimer’s Disease (including proxy) 0.1 0.1 0.9 -0.0 0.2 1.0 -0.5 0.5 0.3 -0.0 0.1 -0.1 0.1 0.1 -0.1 -0.0 -0.4 -0.2 0.7 -0.4
Crohns Disease (2017) 0.1 0.3 1.4 -0.3 0.4 0.1 -0.2 0.1 1.2 -0.2 0.0 0.1 -0.1 -0.7 -0.0 -0.6 -0.7 -0.5 0.9 -0.4
Irritable Bowel Disease (IBD) 0.1 0.3 1.4 0.5 0.1 -0.4 -0.7 -0.3 1.1 0.3 0.3 0.4 0.2 -0.4 0.0 -0.2 -0.6 0.1 1.2 -0.5
Ulcerative Colitis (UC) 0.2 0.3 0.9 0.1 0.4 0.1 -0.1 0.3 0.9 -0.1 0.9 -0.2 -0.1 -0.6 -0.4 -0.3 -0.9 -0.3 0.8 -1.0
Major Depression (MDD) 0.1 0.1 0.7 0.2 0.1 0.6 -0.8 0.2 -0.1 0.0 -0.2 0.2 0.0 0.2 -0.3 0.1 -0.3 0.1 0.3 -0.6
Reaction Time 0.4 0.8 7.3 0.3 0.1 0.1 -0.9 0.5 0.5 0.5 0.2 1.4 0.5 -0.2 -0.2 0.1 -1.3 0.3 2.7 -0.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 2.8 0.2 -0.1 -0.4 0.6 -0.2 -0.6 0.1 -0.9 -0.3 0.2 0.8 0.2 0.4 1.5 0.3 -1.7 0.2
Breast Cancer 0.1 0.1 0.5 -0.7 -0.0 -0.1 -0.6 -0.0 -0.5 -0.3 0.5 -0.0 -0.4 -0.4 0.1 -0.4 -0.3 -0.1 0.0 0.1
Ovarian Cancer 0.4 0.6 1.7 -0.3 -0.8 -0.4 -0.6 -0.6 -1.0 0.6 -1.0 0.6 0.6 0.6 1.0 0.6 1.0 0.4 -0.0 1.3
Prostate Cancer 2.2 3.0 10.9 -2.4 1.6 1.6 3.3 1.6 0.2 -1.8 1.4 -1.9 -1.9 -1.8 -1.2 -1.3 -2.2 -1.6 -0.6 -1.0
Age at First Birth 0.8 1.2 3.8 -1.7 1.0 0.8 0.5 -0.1 0.7 -1.2 0.6 -1.9 -1.1 -0.8 -0.7 -0.7 0.2 -1.0 -2.0 -1.0
Bipolar Disorder (2011) 1.5 1.4 6.8 1.7 -0.8 -0.6 -1.9 -1.3 -0.5 1.3 -0.3 1.3 1.4 0.6 1.0 0.7 -0.2 0.8 2.6 -0.1
Body Mass Index (BMI) (2010) 3.4 4.6 6.5 -2.3 2.4 2.2 1.6 2.2 1.3 -2.4 2.4 -1.9 -2.5 -2.5 -2.0 -2.4 -2.5 -2.1 -0.8 -2.2
Coronary Artery Disease (CAD) 0.4 0.5 1.3 -1.1 0.5 0.8 0.7 0.7 1.0 -0.6 0.6 -0.3 -0.4 -0.8 -0.6 -0.8 -0.7 -0.6 0.7 -0.8
Crohns Disease (2012) 0.7 1.2 2.5 1.4 -1.0 -0.9 -0.7 -1.2 0.6 1.4 -1.4 1.3 1.4 0.6 0.9 0.6 0.5 0.9 1.6 1.1
Mean Putamen Volume 3.3 3.7 6.4 -1.9 2.3 1.8 0.7 1.3 0.8 -2.3 1.6 -2.2 -2.1 -2.2 -2.4 -2.5 -1.4 -1.8 -1.9 -2.3
Fasting Glucose 0.7 0.8 2.4 -0.3 0.8 1.3 1.0 1.5 0.4 -0.8 0.8 -0.5 -0.8 -1.0 -1.0 -1.3 -0.9 -1.1 -0.5 -0.5
HbA1C 0.1 0.1 0.4 0.6 -0.4 -0.4 -0.3 0.4 0.5 0.3 -0.1 0.6 0.2 0.3 0.3 0.0 -0.1 0.6 0.5 0.0
HDL Cholesterol 0.6 0.9 3.8 0.8 -0.1 -0.2 -1.5 -1.1 -0.3 0.4 -1.2 0.1 0.7 1.4 -0.4 0.7 1.9 0.7 -1.6 0.1
LDL Cholesterol 3.5 5.5 14.9 -2.4 2.3 1.9 3.2 1.5 1.0 -2.6 1.8 -2.9 -2.6 -2.0 -2.4 -2.5 -0.4 -2.1 -3.9 -2.0
Lupus 0.3 0.4 1.8 -0.7 0.5 0.4 -0.0 0.6 1.4 -0.6 0.1 -0.5 -0.9 -0.7 -0.6 0.1 -0.5 -0.6 -0.8 -0.1
Neuroticism (2016) 0.3 0.4 1.9 0.7 -0.5 -0.1 0.1 -0.4 -0.8 0.8 -0.4 0.9 1.1 0.7 0.0 -0.3 0.4 0.4 1.4 -0.0
Primary Biliary Cirrhosis 0.7 1.0 2.4 -0.2 0.7 1.0 1.3 1.4 1.3 -0.5 1.5 -0.1 -0.5 -0.8 -0.9 -0.6 -1.6 -0.7 1.1 -0.9
Rheumatoid Arthritis 1.5 2.0 5.0 -1.0 1.2 1.2 1.7 1.0 2.2 -1.2 1.6 -0.7 -1.4 -1.7 -1.6 -1.9 -1.7 -0.9 -0.2 -1.3
Schizophrenia (2014) 1.7 3.7 9.4 2.2 -1.9 -1.9 -3.1 -2.3 -0.5 1.8 -1.3 2.6 1.7 1.9 1.3 1.3 0.9 2.3 1.9 2.0
Triglycerides 0.5 0.7 2.4 -0.9 0.6 0.5 1.5 1.0 0.9 -0.7 1.0 -0.6 -0.9 -1.2 -0.5 -1.0 -0.8 -0.7 -0.2 -0.9
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.4 0.6 -0.4 -0.6 -1.2 0.6 0.1 0.4 1.0 0.7 0.3 -0.5 0.3 -0.3 -1.2 -0.0 0.7 -0.2
Ulcerative Colitis 0.2 0.3 1.6 0.7 0.1 -0.0 -0.7 -0.1 0.3 0.4 0.4 0.3 0.5 -0.3 -0.5 -0.5 -0.3 0.2 1.3 -1.0
Blood Eosinophil Count 0.4 3.1 6.6 -1.8 1.1 1.7 1.4 2.0 2.1 -1.7 1.9 -0.9 -1.9 -2.3 -0.9 -2.3 -2.6 -1.7 0.5 -1.5
Blood Platelet Count 0.5 5.3 12.4 2.6 -2.0 -2.4 -2.9 -2.6 0.1 2.7 -2.1 2.7 2.9 1.7 1.8 1.5 0.9 2.4 3.5 1.8
Blood Red Count 0.0 0.2 0.9 -0.9 0.2 0.3 -0.5 0.3 -0.4 -0.2 -0.1 0.0 -0.3 -0.7 -0.7 -0.6 -0.7 -0.3 -0.2 0.1
Blood White Count 0.0 0.3 1.6 -0.4 -0.0 -0.3 1.1 0.5 0.8 0.2 -0.1 0.1 0.2 -0.3 0.3 0.1 -0.6 -0.1 1.3 0.7
Heel T-Score 0.1 0.7 3.3 0.9 0.1 0.3 -0.4 0.8 1.8 -0.1 0.8 1.4 -0.5 -0.2 -0.6 -0.0 -1.4 0.2 1.3 -0.4
BMI 4.4 25.5 32.9 -5.1 5.5 5.7 5.7 5.3 4.5 -5.1 5.1 -5.2 -4.8 -5.2 -4.7 -5.0 -5.0 -5.7 -1.6 -5.6
Height 5.3 102.1 231.0 -12.7 10.7 9.4 10.6 7.3 3.2 -11.8 7.8 -13.5 -11.6 -9.2 -10.0 -8.8 -3.6 -10.6 -15.2 -8.0
Waist Hip Ratio (WHR) 0.6 2.5 5.3 -0.7 1.4 1.4 0.7 1.9 1.3 -1.4 2.2 -0.4 -1.4 -2.0 -2.1 -2.3 -2.2 -1.0 0.5 -1.9
Systolic Blood Pressure 0.5 2.5 5.2 -1.2 1.9 2.2 1.0 1.3 1.4 -1.2 1.1 -1.0 -1.2 -2.0 -2.1 -1.5 -2.3 -1.5 0.4 -1.9
Smoking Status 0.2 0.4 4.1 -0.2 -0.3 -0.5 -0.7 -0.4 -2.0 0.1 -0.3 0.2 0.2 0.1 0.3 -0.4 0.5 0.2 0.2 0.5
Allergy or Eczema 2.4 6.4 11.5 -2.6 2.8 3.4 2.8 2.5 0.7 -2.6 2.2 -2.5 -2.4 -2.8 -2.6 -2.7 -2.4 -2.9 -1.2 -2.6
Cardiovascular Disease 1.7 5.5 8.2 -2.0 2.6 2.8 2.2 2.3 1.8 -2.3 1.8 -2.9 -2.1 -2.4 -2.7 -2.5 -2.0 -2.5 -1.5 -2.7
Hypothyroidism (self reported) 0.3 0.6 5.4 0.3 -0.4 -0.2 -1.3 -0.3 -0.3 0.4 0.1 1.0 0.5 -0.4 0.6 -0.7 -0.9 0.4 2.3 -0.1
Respiratory disease 2.4 5.4 11.7 -3.4 2.4 2.4 2.5 1.7 0.9 -2.6 1.3 -3.2 -2.4 -2.5 -1.8 -2.4 -1.4 -2.8 -2.4 -2.2
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.4 0.5 0.5 0.8 0.8 0.5 1.0 -0.2 0.9 -0.6 0.0 -0.5 -0.6 -0.8 -0.1 -0.4 0.1 -1.2
Lung FEV1/FVC ratio 0.8 4.2 25.0 1.1 -0.4 -0.1 -0.7 2.0 3.4 0.5 1.0 3.0 -0.1 -1.7 -0.4 -1.2 -3.5 0.3 5.0 -1.4
Lung FVC 2.9 14.7 22.5 -4.7 3.8 3.5 3.8 2.4 0.8 -4.5 3.5 -4.7 -4.7 -4.3 -3.6 -4.0 -2.4 -4.2 -4.7 -3.1
Neuroticism 0.2 0.6 2.6 -0.3 0.6 0.5 1.6 -0.0 -1.4 -0.2 -0.2 -1.0 0.2 0.4 -0.9 -0.4 1.0 -0.2 -1.1 -0.6
Chronotype (morning person) 1.0 2.3 5.6 1.9 -1.7 -2.1 -1.8 -0.6 -0.8 1.6 -0.7 2.4 1.4 1.1 1.3 1.6 0.2 1.6 1.8 1.7
Hair Pigment 0.0 1.3 3.3 0.9 -1.2 -1.4 -0.9 -1.2 0.0 1.2 -1.8 1.1 1.1 0.6 1.1 0.5 1.4 1.6 0.1 1.4
Tanning 0.0 0.3 1.4 0.7 0.1 -0.3 -0.9 -0.3 0.8 0.1 0.4 0.8 0.2 0.1 -0.1 -0.5 -0.7 0.2 1.2 -0.0
Hand grip strength (left) 0.1 0.2 0.9 0.1 0.2 0.4 0.9 -0.1 -0.1 0.1 -0.3 -0.1 0.3 0.5 -0.6 0.3 0.6 -0.3 -0.2 0.0
Number of treatments/medications taken 2.1 3.8 5.4 -2.3 1.8 2.0 2.3 2.0 0.5 -2.0 2.1 -2.0 -2.0 -2.1 -2.1 -2.2 -1.4 -2.0 -1.3 -2.0
Average weekly spirits intake 0.7 0.8 2.1 -0.7 0.7 0.9 0.6 1.1 0.1 -0.8 1.2 -0.8 -0.8 -1.5 -1.0 -1.1 -1.1 -0.9 -0.0 -1.0
Sensitivity / hurt feelings 0.2 0.4 1.2 -0.6 0.4 0.7 0.9 0.7 0.3 -0.2 0.1 -0.4 -0.3 -1.1 -0.4 -0.8 -0.6 -1.0 -0.1 -0.3
Frequency of depressed mood in last 2 weeks 1.1 1.5 4.3 1.1 -1.0 -1.5 -0.3 -1.4 -2.1 1.3 -1.1 1.0 1.6 1.3 0.9 0.4 0.9 1.4 1.4 1.0
Hearing difficulty/problems: Yes 2.0 3.0 11.3 0.8 -1.3 -1.7 -0.7 -2.1 -2.9 0.9 -1.9 0.1 0.9 1.8 1.0 1.1 3.4 1.4 -2.2 2.0
Relative age of first facial hair 0.2 0.4 3.1 -0.1 0.1 0.4 1.2 -0.2 -0.3 -0.2 -0.4 -0.9 -0.2 -0.1 -0.2 -0.1 1.0 -0.1 -1.7 -0.1
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 3.7 -0.3 -0.2 -0.1 1.4 -0.6 -1.9 -0.0 0.1 -0.8 -0.1 -0.4 0.7 -0.1 0.0 -0.3 -0.6 0.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.3 -0.7 0.6 0.1 0.4 0.6 -0.7 -0.6 0.1 -0.7 -0.8 -0.9 -0.7 -0.7 -0.3 -0.4 -1.1 -0.7
Ever had hysterectomy (womb removed) 0.3 0.3 2.0 0.1 -0.0 0.2 -0.7 0.3 1.4 -0.1 0.8 0.3 -0.3 -0.6 -0.3 -0.1 -1.2 -0.3 0.6 -0.5
Systolic blood pressure, automated reading 0.3 1.0 2.9 -0.6 1.3 1.7 0.7 1.2 1.0 -0.6 0.2 -0.5 -0.5 -1.1 -1.5 -0.7 -1.0 -0.9 0.1 -1.4
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.9 1.5 -1.2 -0.9 0.4 -1.5 -1.3 1.1 -0.8 0.4 0.9 1.0 1.3 1.2 1.7 1.0 -0.8 0.6
Angina 0.4 0.5 3.2 0.6 -0.4 -0.3 -0.2 0.2 1.0 0.3 0.2 1.0 0.2 -0.3 0.2 -0.4 -1.4 0.3 1.8 0.3
Medication for hormone replacement therapy 1.2 1.3 2.9 -1.3 1.2 0.9 1.2 0.2 -0.2 -1.3 1.1 -1.7 -1.2 -1.1 -1.0 -1.1 -0.3 -1.1 -1.7 -1.2
Vitamin and mineral supplements 0.3 0.4 1.3 -0.3 -0.5 -0.6 -1.2 -1.2 0.3 0.1 -0.8 0.1 -0.2 0.2 0.5 0.8 0.7 0.2 -0.7 0.6
Supplements: Zinc 0.2 0.2 1.1 0.1 0.3 0.5 -1.0 0.3 0.6 0.1 -0.2 0.3 0.3 0.1 -1.0 -0.7 0.0 0.4 0.2 -0.4
Medication: Co-codamol 0.2 0.3 0.9 0.1 -0.4 -0.7 -1.0 0.0 -0.8 0.4 -0.5 0.2 0.5 0.4 0.8 0.2 0.5 0.5 0.4 -0.0
Medication: Metformin 1.0 1.4 5.8 -0.8 0.8 0.8 2.4 0.6 -0.6 -1.0 1.2 -1.6 -1.2 -1.1 -0.8 -1.2 -0.2 -1.0 -1.8 -1.1
Diabetes (father) 0.4 0.5 1.7 0.7 -0.7 -0.8 -0.8 -0.6 0.1 0.8 -0.7 1.3 0.8 0.7 0.4 0.2 0.6 0.9 0.8 0.4
Diabetes (mother) 0.3 0.3 2.6 -0.4 0.2 0.7 1.0 0.1 0.2 -0.3 -0.2 -0.7 -0.4 -0.1 -0.1 -0.2 0.8 -0.3 -1.6 0.2
Severe depression (siblings) 0.6 0.6 1.4 1.1 -0.7 -0.7 -0.4 -1.1 -0.5 0.7 -0.6 0.8 0.9 1.2 0.4 0.3 1.1 1.0 0.4 0.3
Pack years adult smoking proportion 2.6 4.0 6.5 -2.5 2.2 1.9 2.4 2.3 1.9 -2.0 1.4 -1.7 -1.8 -2.5 -1.9 -2.1 -2.3 -2.0 -0.2 -1.4
Impedance of leg (right) 0.2 0.9 3.8 1.1 -0.6 -0.8 -0.7 -0.3 -1.1 0.4 -0.7 0.6 0.4 1.1 0.3 0.8 1.9 1.4 -1.4 1.0
Leg fat-free mass (left) 6.2 32.6 49.8 -6.9 6.1 5.8 6.9 5.0 3.1 -6.3 4.8 -7.1 -6.1 -5.7 -5.2 -5.2 -3.8 -6.6 -5.3 -5.4
Trunk fat percentage 8.6 34.4 49.4 -7.0 6.2 6.0 5.8 6.1 3.6 -6.6 5.3 -6.7 -6.6 -6.1 -5.3 -5.7 -4.3 -6.5 -5.4 -5.3
Hand grip strength (right) 0.1 0.3 1.3 -0.2 0.7 0.9 1.1 0.3 0.5 -0.1 -0.0 -0.5 0.3 -0.1 -1.0 -0.3 0.2 -0.7 0.2 -0.8
Townsend deprivation index at recruitment 1.4 2.0 5.7 1.2 -1.7 -1.6 -2.4 -1.6 -0.0 1.4 -0.8 1.3 1.2 1.4 1.5 1.9 1.3 1.7 0.6 0.9
Current tobacco smoking 0.1 0.1 0.9 -0.1 0.0 -0.5 0.9 0.0 -0.4 -0.1 -0.0 0.2 -0.1 -0.3 0.1 -0.3 0.1 0.3 0.1 0.4
Average weekly fortified wine intake 0.1 0.1 0.4 0.2 -0.4 -0.1 0.3 0.2 -0.4 0.3 -0.4 0.0 0.1 -0.1 0.6 0.3 -0.3 -0.2 0.6 0.3
Maternal smoking around birth 0.8 1.2 3.7 1.0 -0.7 -1.0 0.4 -1.0 -0.7 1.3 -1.9 0.7 1.6 1.2 0.7 0.8 1.9 1.3 0.2 0.5
Fed-up feelings 0.3 0.5 3.4 -1.0 0.3 0.3 1.8 -0.1 -0.5 -0.4 -0.0 -1.0 -0.3 -0.1 -0.6 -0.5 0.5 -0.5 -1.0 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 1.0 -0.1 -0.1 -0.5 0.4 -0.5 -0.9 0.5 -0.6 0.0 1.0 0.5 0.1 -0.4 0.5 0.5 0.9 0.0
Relative age voice broke 2.8 4.3 7.6 2.4 -2.8 -2.2 -1.0 -1.8 -2.0 2.2 -1.8 2.2 1.9 1.9 2.5 2.3 1.9 2.1 0.8 2.7
Taking other prescription medications 2.3 3.6 6.1 -2.2 1.9 2.1 1.9 2.5 0.9 -1.8 2.0 -2.1 -1.6 -2.1 -1.4 -2.2 -1.9 -2.0 -0.2 -2.3
Age when periods started (menarche) 0.5 1.1 4.5 -0.8 1.1 1.3 1.4 -0.3 0.0 -1.0 0.5 -1.5 -1.0 -0.6 -1.4 -0.6 0.1 -1.0 -2.1 -0.7
Bilateral oophorectomy (both ovaries removed) 6.1 7.0 11.3 -2.2 2.9 2.8 2.3 3.4 2.2 -2.6 3.0 -2.6 -2.4 -2.8 -2.8 -2.9 -2.7 -2.7 -1.1 -2.9
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.8 0.1 -0.2 0.1 0.9 0.4 0.8 -0.3 0.6 0.2 -0.7 -0.1 0.0 0.3 -0.4 -0.3 -0.2 0.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 1.2 0.3 -0.1 0.5 0.0 0.6 0.4 0.5 -0.5 0.5 0.5 -0.2 -0.2 -0.3 -0.4 0.0 1.1 0.1
Qualifications: CSEs or equivalent 0.8 1.0 2.5 -1.0 1.2 1.3 0.9 1.1 0.5 -0.8 0.4 -1.0 -0.4 -0.7 -1.6 -1.6 -0.7 -0.8 0.3 -1.3
Serious illness, injury or assault to yourself 0.2 0.2 0.7 0.2 0.6 0.7 0.9 0.4 -0.3 0.0 -0.5 -0.7 0.2 -0.0 -0.5 -0.4 0.3 -0.1 -0.5 0.1
High blood pressure 1.8 5.1 7.8 -1.9 2.1 2.1 2.0 2.0 2.3 -2.2 2.3 -2.4 -2.5 -2.8 -2.2 -2.5 -2.5 -2.4 -1.6 -2.2
Hayfever, allergic rhinitis or eczema 3.4 7.3 14.1 -2.8 3.0 3.8 2.7 2.7 0.9 -2.8 2.1 -2.6 -2.5 -3.1 -2.8 -3.0 -2.5 -3.2 -1.2 -3.0
Multivitamins +/- minerals 0.3 0.4 1.7 0.1 0.6 0.7 0.4 1.3 -0.4 -0.2 0.8 -0.4 -0.1 -0.2 -0.7 -0.8 -0.8 -0.4 0.2 -0.6
Stomach or abdominal pain in last month 0.5 0.6 1.3 0.4 -0.9 -1.1 -0.9 -0.6 -1.1 0.7 -0.4 0.8 0.6 0.4 1.0 0.6 -0.0 0.8 1.1 1.1
Supplements: Glucosamine 0.4 0.6 2.2 0.8 -0.5 -0.4 -0.0 -0.4 -1.5 0.5 -0.0 0.2 0.5 1.1 0.3 1.1 1.2 0.4 -0.9 0.7
Diverticular disease/diverticulitis (self-reported) 0.6 0.8 3.5 -0.6 0.7 0.5 0.9 0.6 -1.5 -0.7 0.4 -1.3 -0.5 -0.2 -0.6 -0.4 1.0 -0.7 -1.9 -0.9
Medication: Atenolol 0.5 0.7 1.4 -1.2 0.8 0.7 0.6 1.1 0.0 -0.8 0.4 -1.1 -0.7 -0.9 -0.1 -1.0 -1.1 -0.9 0.3 -0.9
Medication: Levothyroxine sodium 0.3 0.5 3.0 -0.1 -0.9 -0.5 -1.4 -0.1 -0.2 0.5 0.1 0.7 0.5 -0.1 1.1 -0.0 -0.6 0.0 1.7 0.5
Sitting height 3.3 23.7 54.3 -6.2 5.0 4.3 6.4 3.3 1.3 -5.5 3.5 -7.1 -5.5 -4.3 -3.7 -3.4 -1.5 -5.4 -7.4 -4.0
Chronic bronchitis/emphysema (father) 0.9 1.0 3.1 -0.8 1.4 0.7 -0.3 0.7 1.0 -0.8 0.3 -1.8 -0.4 -0.9 -1.3 -1.0 0.2 -1.0 -1.8 -1.1
High blood pressure (mother) 3.7 5.2 8.6 -2.8 2.2 2.5 2.1 1.8 1.8 -2.7 1.7 -2.9 -2.8 -2.2 -1.8 -1.8 -1.2 -2.7 -2.9 -2.0
Body mass index (BMI) 3.2 13.8 18.1 -4.2 4.0 4.0 3.8 4.1 2.9 -3.8 3.6 -3.8 -3.6 -4.0 -3.5 -3.8 -3.7 -4.2 -1.3 -3.9
Impedance of leg (left) 0.4 1.7 4.9 1.3 -1.2 -1.3 -1.1 -0.9 -1.5 0.9 -1.2 1.1 0.8 1.5 0.8 1.3 2.2 1.8 -1.2 1.6
Leg predicted mass (left) 6.2 32.7 49.8 -6.9 6.1 5.8 6.8 5.1 3.1 -6.3 4.8 -7.1 -6.1 -5.7 -5.2 -5.2 -3.8 -6.6 -5.4 -5.4
Trunk fat mass 9.7 41.5 58.8 -7.7 6.9 6.7 7.0 6.5 3.8 -7.2 5.7 -7.5 -7.1 -6.5 -5.9 -6.1 -4.5 -7.2 -6.0 -6.0
Waist circumference 7.4 26.9 35.8 -6.0 5.5 5.2 5.2 5.6 3.0 -5.6 5.1 -5.7 -5.5 -5.6 -5.1 -5.4 -4.5 -5.7 -3.4 -5.0
Number of incorrect matches in round 0.2 0.3 0.6 0.4 -0.7 -0.1 -0.6 -0.4 -0.1 0.4 0.4 0.8 0.3 0.5 0.8 0.7 -0.1 0.3 0.7 0.5
Past tobacco smoking 0.7 1.2 4.2 -0.5 1.1 0.9 2.0 0.8 1.8 -0.9 1.1 -1.0 -1.0 -1.0 -1.0 -0.6 -1.0 -0.8 -0.9 -1.2
Alcohol usually taken with meals 0.2 0.3 2.2 0.1 -0.4 -0.4 -1.5 0.1 -1.0 -0.0 0.1 0.3 -0.1 0.5 0.3 0.9 0.3 0.4 -0.4 0.6
Nervous feelings 0.6 1.1 2.7 1.6 -0.9 -0.9 -0.6 -0.2 -1.6 1.3 -1.2 0.8 1.4 1.1 0.8 1.0 0.9 1.1 0.9 0.7
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 4.7 0.6 -0.7 -1.0 -0.8 -0.2 -0.7 1.0 -0.7 0.9 1.4 0.7 0.6 -0.0 -0.1 0.9 2.2 0.9
Hearing difficulty/problems with background noise 3.2 5.1 8.6 2.2 -2.8 -2.6 -0.5 -2.4 -2.0 2.5 -2.5 1.8 2.4 2.2 2.9 1.9 2.5 2.1 0.9 2.8
Hair/balding pattern: Pattern 2 0.6 0.8 3.5 0.9 -0.5 -1.1 -1.1 -0.4 -1.9 0.7 -0.9 0.8 0.7 0.9 0.5 0.6 1.1 0.9 -0.1 0.6
Had menopause 0.4 0.5 1.3 -1.1 0.6 0.5 0.8 0.7 -0.4 -0.7 0.5 -0.8 -0.7 -0.9 -0.2 -0.5 -0.4 -0.6 -1.0 -0.4
Had other major operations 0.6 0.8 2.3 -0.8 0.5 0.3 -0.2 1.4 -0.7 -0.8 1.4 -0.4 -1.0 -1.4 -0.3 -0.5 -1.5 -0.8 0.3 -0.7
Forced vital capacity (FVC) 6.2 23.7 49.7 -6.0 5.2 4.6 6.0 3.0 0.8 -5.6 3.4 -6.7 -5.4 -4.6 -4.4 -4.5 -1.6 -5.4 -7.0 -3.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.7 0.9 -0.9 -0.6 0.2 0.3 0.7 0.6 -0.3 1.3 0.2 0.5 0.5 1.0 0.1 0.6 0.7 0.9
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.9 -1.0 1.2 1.0 1.2 1.2 -0.2 -1.1 1.1 -0.9 -1.0 -1.0 -1.4 -1.3 -1.1 -1.0 -0.3 -1.2
Qualifications: None of the above 0.2 0.5 1.0 0.3 -0.6 -0.8 -0.7 -1.0 -0.8 0.7 -1.0 0.5 0.6 0.2 0.9 0.7 0.8 0.7 0.2 0.7
Financial difficulties in last 2 years 3.7 4.9 7.1 -2.4 2.4 2.3 2.6 2.2 1.4 -2.4 2.0 -2.2 -2.4 -2.7 -1.9 -2.3 -2.5 -2.4 -1.0 -2.0
Mouth/teeth dental problems 0.1 0.1 0.3 0.6 -0.0 0.4 0.2 -0.2 0.2 -0.1 -0.1 -0.1 -0.4 -0.2 -0.4 0.2 -0.3 -0.2 -0.4 -0.2
Heart attack 0.7 0.8 2.3 -1.4 0.8 0.8 1.2 0.5 0.8 -1.0 0.7 -1.1 -1.1 -0.7 -0.2 -0.7 0.3 -1.0 -1.5 -0.7
Allergy 6.0 13.8 20.9 4.4 -4.1 -4.6 -3.7 -3.5 -1.8 3.9 -2.9 4.1 3.6 4.0 3.9 3.9 2.9 4.2 2.5 4.0
Pain all over the body in last month 1.2 1.3 3.2 -0.8 1.3 1.1 1.8 1.1 0.0 -1.2 0.9 -1.5 -1.2 -1.1 -0.5 -0.9 -0.4 -1.3 -1.5 -1.1
Diabetes (self-reported) 0.5 0.8 2.1 -0.6 0.7 1.0 1.4 0.5 0.3 -0.8 1.1 -1.2 -0.9 -0.8 -0.7 -0.7 -0.3 -1.0 -1.3 -1.0
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.4 -1.6 1.4 1.4 0.4 1.4 -0.3 -1.4 0.4 -1.7 -1.1 -1.0 -1.4 -0.9 -0.1 -1.3 -1.8 -1.3
Medication: Ramipril 0.2 0.3 2.6 0.0 -0.1 0.2 1.6 0.0 -0.1 -0.3 0.2 -0.0 -0.5 -0.6 0.0 -1.1 -0.0 -0.3 -0.4 -0.5
Medication: Simvastatin 1.5 2.2 4.1 -1.0 1.1 1.5 1.4 1.9 1.0 -1.2 1.6 -1.3 -1.4 -2.0 -1.2 -1.9 -1.8 -1.4 -0.1 -1.9
Fluid intelligence score 0.1 0.3 1.9 -0.3 0.1 -0.1 -0.2 -0.1 -1.4 -0.4 -0.3 -0.6 -0.5 0.0 0.5 0.2 0.4 -0.1 -1.4 -0.1
Illnesses of siblings 0.3 0.4 3.5 0.5 -0.0 -0.5 -1.9 -0.5 -0.5 0.3 -0.6 0.6 0.6 0.3 -0.5 -0.3 0.1 0.6 0.9 -0.1
Neuroticism score 0.2 0.3 1.8 -0.7 0.3 0.2 1.3 -0.0 -1.0 -0.1 -0.3 -0.7 0.2 0.1 -0.6 -0.3 0.6 -0.3 -0.7 0.0
Weight 8.0 39.5 58.3 -7.6 6.8 6.4 7.3 6.1 3.3 -6.9 5.4 -7.6 -6.7 -6.4 -5.8 -5.9 -4.4 -7.1 -5.5 -5.9
Impedance of arm (right) 0.9 4.3 23.6 -2.4 1.9 1.4 1.0 1.1 -0.4 -2.5 1.1 -2.9 -2.6 -1.6 -1.7 -1.8 0.2 -1.6 -4.9 -0.9
Arm fat percentage (right) 6.1 24.0 33.8 -5.8 5.2 5.1 4.7 5.2 3.2 -5.5 4.5 -5.6 -5.4 -5.1 -4.4 -4.7 -4.0 -5.6 -3.9 -4.5
Trunk fat-free mass 3.2 18.2 38.4 -5.2 4.5 4.3 6.2 3.7 1.4 -4.7 3.5 -5.5 -4.6 -3.9 -3.7 -3.2 -2.4 -4.9 -4.5 -3.9
Hip circumference 5.9 25.3 40.8 -6.2 5.4 5.1 5.2 5.0 2.4 -5.6 4.2 -6.4 -5.4 -5.0 -4.8 -4.9 -3.2 -5.7 -5.0 -4.5
Time employed in main current job 0.8 0.9 3.1 1.6 -0.9 -0.5 -1.3 -0.5 1.0 0.9 -0.0 1.8 0.7 0.8 -0.0 0.6 0.2 1.6 1.0 0.0
Alcohol intake versus 10 years previously 1.2 1.7 3.6 -1.3 1.4 0.8 1.9 1.1 0.7 -1.5 1.9 -1.3 -1.5 -1.5 -1.1 -1.3 -1.4 -1.2 -0.7 -1.1
Father’s age at death 0.4 0.6 4.8 0.4 0.2 0.0 -1.4 0.0 -2.2 0.3 -0.8 0.1 0.7 0.7 -0.6 0.3 0.6 0.4 0.1 -0.0
Worrier / anxious feelings 0.4 0.8 4.4 0.0 -0.8 -0.9 1.0 -0.7 -2.1 0.5 -0.8 0.1 0.5 0.8 1.1 0.5 0.9 0.4 -0.2 1.5
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.8 0.1 -0.5 -0.6 0.8 -0.2 -0.3 0.5 -0.6 0.3 0.7 0.2 0.3 0.1 0.3 0.6 0.9 0.2
Falls in the last year 0.7 0.9 2.7 0.7 -1.3 -1.6 -0.2 -0.5 -0.1 1.2 -1.1 0.8 1.1 0.4 1.6 0.5 0.7 0.9 0.8 1.0
Hair/balding pattern: Pattern 3 0.2 0.3 1.1 -0.7 0.0 -0.1 1.0 0.8 0.7 -0.5 0.5 -0.1 -0.7 -0.5 0.1 -0.5 -0.8 -0.5 -0.0 0.6
Number of live births 0.3 0.4 1.6 -0.7 0.8 0.4 0.3 0.5 -1.1 -0.6 -0.2 -0.5 -0.6 -0.7 -1.3 -0.8 -0.2 -0.0 -0.8 -0.6
Forced expiratory volume in 1-second (FEV1) 4.8 16.2 26.2 -4.7 4.4 3.9 5.1 3.2 1.3 -4.6 3.1 -4.8 -4.4 -4.3 -4.0 -4.2 -2.4 -4.3 -4.2 -3.7
Pulse rate 0.3 0.5 3.2 -0.3 0.5 0.1 0.8 -0.5 -0.5 -0.2 -0.4 -0.5 0.1 0.6 -1.0 0.1 1.4 0.4 -1.8 -0.2
Happiness 0.2 0.2 0.7 0.4 -0.1 -0.4 -0.2 -0.1 -0.8 0.2 -0.3 0.3 0.5 0.6 0.0 -0.4 0.4 0.7 0.7 -0.1
Noisy workplace 0.4 0.5 2.6 -0.4 0.7 0.6 0.1 0.9 0.3 -0.3 0.2 -0.6 -0.2 -1.1 -0.9 -1.6 -0.6 -0.7 0.0 -0.8
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.8 -0.1 0.3 0.2 -0.5 -0.5 -0.9 -0.1 -0.4 -0.3 0.1 0.4 -0.1 0.1 0.6 -0.2 -0.6 -0.2
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 2.8 0.5 0.3 0.2 -0.3 0.4 -0.3 0.2 0.1 0.5 0.4 -0.1 -0.5 -0.8 -0.9 -0.1 1.7 -0.3
Mouth/teeth dental problems: Dentures 0.4 0.7 1.5 -1.2 1.0 0.5 0.4 1.2 0.5 -0.7 0.6 -1.0 -0.4 -0.9 -0.5 -1.2 -0.7 -0.6 0.3 -1.2
Asthma 0.4 0.8 2.2 -1.5 0.8 0.8 0.8 1.0 0.4 -0.9 0.4 -1.2 -0.7 -1.0 -0.8 -1.3 -0.6 -1.0 -0.6 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.8 -0.6 0.5 0.0 0.6 0.1 -1.1 -0.1 -0.6 -1.0 0.2 0.2 -0.5 -0.1 1.4 -0.1 -1.1 -0.1
Medication: Cholesterol lowering 0.8 1.2 2.3 -1.1 0.9 0.8 0.9 1.2 -0.5 -1.2 1.5 -0.8 -1.5 -1.4 -0.7 -1.4 -1.0 -1.2 -0.8 -1.3
Depression (self-reported) 0.6 0.7 3.0 0.8 -0.2 -0.3 -1.7 -0.3 -1.7 0.6 -0.5 0.9 0.8 0.6 -0.4 -0.3 0.1 0.8 1.2 0.4
Medication: Lansoprazole 0.2 0.2 1.0 -0.4 0.1 -0.2 1.0 -0.4 -0.4 -0.4 0.2 -0.3 -0.6 -0.3 0.3 -0.1 -0.3 -0.1 -0.6 0.4
Prospective memory result 0.3 0.4 0.9 -0.7 0.6 0.3 -0.6 0.1 0.7 -0.5 0.7 -0.7 -0.4 -0.6 -0.5 -0.7 -0.2 -0.7 -0.4 -1.0
Lung cancer (father) 2.1 2.5 5.1 -2.3 1.8 1.5 1.4 1.8 0.7 -1.8 0.9 -1.9 -1.7 -1.7 -1.5 -1.4 -1.0 -1.6 -1.6 -1.4
Illnesses of mother 3.7 4.5 8.0 2.0 -2.1 -2.3 -2.3 -1.7 -1.4 2.4 -1.5 2.7 2.5 2.2 1.8 2.2 1.0 2.6 2.8 1.7
Forced expiratory volume in 1-second (FEV1), Best measure 5.8 18.5 29.6 -4.9 4.7 4.2 5.4 3.5 1.5 -4.8 3.5 -5.1 -4.8 -4.6 -4.1 -4.4 -2.8 -4.7 -4.3 -4.0
Pulse wave Arterial Stiffness index 0.2 0.2 1.0 0.6 0.2 0.4 0.6 0.7 0.4 -0.2 0.3 0.2 -0.1 -0.0 -0.9 -1.0 0.1 0.3 -0.2 -0.5
Impedance of arm (left) 1.1 5.2 21.1 -2.5 2.4 1.9 1.0 1.4 0.4 -2.8 1.5 -3.0 -2.9 -2.1 -2.2 -2.4 -0.3 -1.9 -4.6 -1.3
Arm fat mass (right) 7.2 29.7 42.4 -6.5 5.8 5.7 5.9 5.6 3.5 -6.0 4.9 -6.4 -5.9 -5.6 -4.9 -5.0 -4.2 -6.3 -4.6 -5.0
Trunk predicted mass 3.2 18.2 38.3 -5.2 4.4 4.3 6.2 3.7 1.4 -4.7 3.5 -5.5 -4.6 -3.9 -3.7 -3.2 -2.4 -4.9 -4.5 -3.9
Standing height 4.3 43.0 98.0 -8.1 6.9 6.1 8.2 4.9 1.5 -7.5 4.8 -9.0 -7.4 -5.7 -5.8 -5.2 -2.0 -7.0 -9.9 -5.1
Length of working week for main job 1.5 1.6 3.3 -1.5 1.4 1.2 0.1 1.7 1.8 -1.3 1.4 -1.0 -1.1 -1.1 -1.3 -1.2 -1.1 -1.3 0.0 -1.8
Exposure to tobacco smoke at home 0.3 0.3 1.1 -0.3 0.6 0.9 -0.3 0.4 -0.5 -0.4 0.1 -0.1 -0.3 -0.6 -1.1 -0.9 -0.3 -0.4 0.1 -0.6
Breastfed as a baby 0.4 0.5 3.6 0.8 -0.2 -0.0 -1.9 0.4 -0.9 0.4 -0.6 0.5 0.7 0.8 -0.0 -0.2 0.4 0.6 0.8 -0.3
Tense / ‘highly strung’ 0.1 0.2 1.2 0.9 -0.1 -0.0 0.1 -0.4 -1.1 0.5 -0.4 -0.2 0.8 0.4 0.3 -0.2 0.5 0.2 0.4 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 9.0 -0.6 -0.5 -1.1 -1.6 -0.8 -3.0 -0.0 -0.4 -0.2 -0.3 0.2 0.8 0.3 0.7 0.1 -1.3 0.8
Hair/balding pattern: Pattern 4 0.2 0.4 2.3 0.2 -0.1 0.2 -0.1 0.0 1.5 0.7 -0.7 0.6 0.9 -0.2 -0.0 0.2 -0.0 0.1 1.5 -0.2
Birth weight of first child 3.1 5.5 20.2 -2.6 2.4 2.0 3.5 1.4 -0.7 -2.4 1.6 -3.6 -2.4 -1.3 -2.0 -1.6 0.0 -2.2 -4.5 -1.6
Peak expiratory flow (PEF) 2.9 6.6 13.8 -3.1 2.6 2.0 3.7 2.1 0.5 -2.9 2.3 -2.9 -3.0 -2.8 -2.2 -2.8 -1.8 -2.7 -2.8 -2.2
Pulse wave reflection index 1.3 1.6 3.7 1.9 -1.6 -1.1 -0.2 -1.0 -1.3 1.4 -1.0 1.4 1.3 1.5 1.3 0.8 1.4 1.2 0.4 1.6
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.0 -1.0 0.7 0.3 -0.2 0.7 0.3 -0.4 0.1 -0.9 -0.3 -0.7 -0.6 -0.6 -0.7 -0.8 -0.2 -0.8
Loud music exposure frequency 1.9 2.1 3.7 1.9 -1.7 -1.6 -1.6 -0.6 0.3 1.8 -1.0 1.9 1.6 1.5 1.2 1.4 0.7 1.4 1.8 1.3
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.8 0.2 -1.2 -1.1 -0.6 -1.2 -1.5 0.9 -1.7 0.5 0.8 1.5 1.0 1.5 1.5 1.1 -0.6 1.5
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.7 -0.3 -0.8 -0.7 0.3 -0.4 -1.2 0.6 -0.2 0.7 0.6 0.3 1.2 0.3 -0.1 0.3 1.3 1.1
Blood clot in the leg (DVT) 1.4 1.9 4.4 -1.3 1.5 1.4 1.1 1.2 -0.0 -1.3 1.6 -1.3 -1.2 -1.4 -2.1 -1.8 -1.2 -1.3 -0.9 -1.4
Medication: Paracetamol 1.7 2.9 4.3 -2.1 2.0 1.9 1.9 1.9 -0.1 -1.9 1.6 -1.6 -1.7 -1.9 -1.8 -2.0 -1.4 -1.8 -0.9 -1.4
Headache pain in last month 0.7 1.3 2.6 -1.5 1.3 1.6 1.2 0.9 -0.3 -1.1 1.0 -1.4 -0.8 -1.1 -1.3 -1.4 -0.9 -1.2 -0.4 -0.7
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 4.4 1.2 -1.1 -1.2 -1.2 -1.2 -0.5 1.6 -2.1 1.1 2.0 1.7 1.1 1.7 1.6 1.4 1.0 1.5
Glaucoma (self-reported) 2.0 2.4 5.7 1.9 -1.8 -1.8 -0.7 -0.7 -1.5 1.7 -1.0 1.7 1.6 1.1 2.4 1.7 0.8 1.7 1.7 1.4
Gout (self-reported) 0.4 0.6 1.8 -0.4 0.6 1.0 0.2 0.6 0.2 -0.7 0.7 -0.7 -0.6 -0.8 -0.9 -1.4 -0.5 -0.9 -0.1 -1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 2.4 -0.1 -0.3 -0.3 -1.5 -0.1 -0.5 0.1 0.3 0.4 0.2 -0.6 0.6 -0.8 -0.8 -0.0 1.6 -0.3
Medication: Amlodipine 0.3 0.5 3.1 0.7 -0.1 0.4 0.2 0.0 0.2 0.2 0.8 0.7 -0.0 -0.7 0.0 -0.6 -1.2 0.0 1.8 -0.5
Medication: Ventolin 100micrograms inhaler 1.6 2.1 5.3 -1.6 1.7 1.8 -0.1 1.8 1.0 -1.3 0.8 -1.3 -1.0 -1.6 -2.3 -1.5 -1.3 -1.5 -0.5 -1.7
Birth weight 0.9 1.9 8.6 -1.6 1.4 1.1 1.0 0.3 -0.4 -1.6 0.4 -2.3 -1.8 -1.2 -1.4 -0.8 0.1 -1.1 -2.9 -0.9
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.9 0.8 -0.1 -0.5 -0.0 0.3 0.1 0.5 0.3 0.6 0.5 0.1 0.2 0.2 -0.3 0.4 0.9 0.1
High blood pressure (siblings) 0.1 0.1 0.6 -0.2 -0.4 -0.1 0.8 0.2 0.4 0.1 -0.1 0.1 -0.3 -0.1 0.4 0.5 -0.0 -0.1 -0.4 0.6
Forced vital capacity (FVC), Best measure 6.9 25.2 46.8 -6.1 5.4 4.8 6.3 3.2 0.9 -5.7 3.8 -6.8 -5.6 -4.9 -4.4 -4.6 -2.2 -5.6 -6.8 -4.1
Body fat percentage 7.3 29.0 40.1 -6.3 5.7 5.6 5.4 5.8 3.5 -6.0 4.9 -6.1 -5.9 -5.6 -5.0 -5.3 -4.1 -6.0 -4.5 -5.0
Leg fat percentage (right) 4.5 16.2 22.3 -4.3 4.4 4.4 4.3 4.7 2.9 -4.3 3.9 -4.3 -4.0 -4.0 -4.1 -4.1 -3.1 -4.2 -2.7 -4.1
Arm fat-free mass (right) 3.8 19.4 37.2 -5.4 4.6 4.5 6.1 4.2 2.3 -4.8 3.8 -5.2 -4.7 -4.4 -3.8 -3.7 -3.0 -5.1 -3.7 -4.1
Exposure to tobacco smoke outside home 0.4 0.5 3.6 0.7 -0.6 -0.6 -0.6 0.2 0.1 0.4 0.7 0.8 0.4 0.6 0.9 0.5 -0.7 0.4 1.9 0.1
Comparative body size at age 10 1.0 2.6 10.4 1.4 -1.6 -2.0 -2.2 -0.7 1.5 1.7 -0.9 2.2 1.6 0.8 1.8 0.9 -0.6 1.3 3.2 0.8
Number of full brothers 3.5 4.4 8.5 2.0 -2.1 -2.3 -2.9 -2.1 -0.7 2.1 -2.0 2.1 2.1 2.4 1.9 2.4 2.3 2.5 0.9 1.8
Worry too long after embarrassment 0.2 0.3 1.1 -0.8 0.5 0.6 1.1 0.7 -0.4 -0.5 0.4 -0.2 -0.3 -0.3 -0.5 -0.7 -0.6 -0.7 0.5 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.6 -0.5 -0.6 -1.0 -1.6 -0.9 -1.2 0.3 -0.4 0.0 0.2 0.3 1.1 0.6 0.6 0.3 -0.2 0.7
Wheeze or whistling in the chest in last year 1.0 1.8 3.2 -1.8 1.4 1.8 1.2 1.6 -0.4 -1.2 1.0 -1.5 -0.9 -1.5 -1.3 -1.8 -1.1 -1.7 -0.3 -1.2
Number of children fathered 0.5 0.6 2.1 0.6 -0.7 -0.6 0.2 -0.7 0.0 0.9 -1.0 0.7 0.9 0.8 1.0 1.4 0.4 0.5 0.8 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.6 2.1 1.4 -0.7 -1.0 -0.4 -0.6 0.6 0.8 0.1 1.1 0.7 0.7 0.9 0.8 0.2 0.9 0.9 0.6
Age at first live birth 0.2 0.3 1.9 0.8 -0.1 0.0 -0.2 0.1 1.1 0.4 0.2 0.2 0.7 0.7 0.4 0.4 -0.2 -0.1 1.4 -0.3
Pulse wave peak to peak time 0.2 0.2 1.0 -1.0 0.2 -0.0 -0.1 -0.5 -0.4 -0.2 -0.0 -0.7 -0.3 -0.3 0.6 0.7 -0.2 -0.7 -0.3 0.2
Health satisfaction 0.4 0.6 1.8 -1.1 0.8 0.8 1.1 0.9 0.0 -0.6 -0.3 -0.4 -0.4 -0.9 -0.6 -1.3 -0.6 -0.5 0.4 -0.9
Shortness of breath walking on level ground 0.4 0.5 1.5 -0.1 0.6 0.9 0.8 0.9 0.6 0.0 -0.2 -0.4 0.5 -0.5 -0.7 -0.9 -0.6 -0.6 1.2 -0.8
Qualifications: College or University degree 1.4 4.4 7.5 -1.6 2.6 2.7 0.5 2.3 1.2 -2.4 2.7 -2.0 -2.3 -1.7 -2.6 -1.8 -1.6 -2.3 -1.6 -2.5
Eye problems/disorders: None of the above 1.1 1.3 2.2 -1.4 1.4 1.2 1.2 0.8 1.0 -1.4 1.0 -1.2 -1.3 -0.9 -1.2 -1.0 -0.8 -1.5 -1.0 -0.6
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.6 0.6 -1.2 -1.6 -0.5 -0.7 -1.5 1.1 -1.3 1.2 1.1 0.8 1.4 0.2 0.9 1.4 0.5 1.2
Emphysema/chronic bronchitis 0.4 0.4 1.2 -0.7 -0.3 -0.4 -0.8 -0.9 0.7 0.2 -0.9 0.2 0.3 0.4 1.1 0.7 1.1 0.1 -0.3 0.5
Medication for pain relief, constipation, heartburn 3.2 5.5 8.2 2.7 -2.5 -2.3 -2.3 -2.6 -0.8 2.7 -2.5 2.4 2.6 2.5 2.6 2.9 1.7 2.3 1.6 2.3
Neck or shoulder pain in last month 1.2 1.7 4.0 0.6 -1.1 -1.3 -1.6 -1.9 -1.1 1.3 -2.0 0.7 1.5 1.4 1.3 1.2 1.6 1.3 0.2 1.1
Medication: Blood pressure 0.9 1.6 4.8 -0.5 0.9 0.9 0.9 0.7 1.0 -1.3 2.2 -0.8 -1.9 -1.5 -1.1 -1.3 -1.5 -1.2 -1.0 -1.4
Angina (self-reported) 0.3 0.4 2.4 0.6 -0.3 -0.3 -0.0 0.2 0.9 0.3 0.3 0.8 0.1 -0.3 0.1 -0.4 -1.3 0.2 1.5 0.3
Migraine (self-reported) 1.9 2.3 4.7 -1.9 1.5 1.6 1.4 1.3 -0.2 -1.5 1.8 -1.6 -1.6 -1.9 -1.4 -1.5 -2.2 -1.6 -0.5 -1.4
Medication: Ibuprofen 0.4 0.5 1.5 -0.9 0.6 0.1 0.4 0.3 -1.2 -0.3 -0.7 -1.1 -0.1 0.0 -0.5 0.0 1.0 -0.2 -1.2 -0.1
Medication: Allopurinol 0.9 1.2 2.8 -1.1 0.8 1.2 1.1 0.8 0.7 -1.2 1.3 -1.1 -1.3 -1.3 -0.7 -1.7 -1.3 -1.2 -0.3 -1.2
Medication: Omeprazole 2.8 3.4 7.0 -2.0 1.7 1.9 1.2 2.6 1.8 -2.0 1.9 -1.9 -1.8 -1.8 -1.9 -2.1 -1.6 -1.7 -1.1 -1.5
Medication: Seretide 50 evohaler 2.8 3.2 5.1 -2.2 1.7 1.6 2.2 2.1 0.9 -1.7 1.6 -1.9 -1.6 -2.2 -1.2 -1.8 -1.9 -2.3 -0.5 -1.8
Mean time to correctly identify matches 0.3 0.6 4.8 0.1 -0.1 0.0 -1.0 1.0 0.3 0.2 0.4 1.2 0.1 -0.4 0.3 -0.0 -1.4 -0.0 2.2 0.2
Heart disease (mother) 0.3 0.4 5.5 0.1 -0.0 0.2 -0.4 -0.4 2.4 -0.0 0.0 -0.2 -0.1 -0.6 0.3 -0.4 -0.3 -0.4 0.2 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 1.5 1.1 -1.0 -0.9 0.2 -1.2 -1.2 1.1 -0.9 0.5 1.1 0.9 1.2 0.7 1.1 0.9 0.1 1.2
Whole body fat mass 9.2 38.3 52.3 -7.2 6.6 6.5 6.7 6.3 3.8 -6.9 5.6 -7.1 -6.7 -6.2 -5.8 -5.9 -4.5 -6.9 -5.4 -5.8
Leg fat mass (right) 7.4 28.6 37.2 -6.0 5.8 5.8 6.0 5.7 3.6 -5.8 4.9 -6.1 -5.5 -5.3 -5.2 -5.2 -3.9 -5.9 -4.0 -5.2
Arm predicted mass (right) 3.6 18.4 34.5 -5.3 4.5 4.5 5.9 4.2 2.3 -4.7 3.6 -5.1 -4.6 -4.2 -3.7 -3.5 -2.9 -5.0 -3.7 -4.0
Pulse rate, automated reading 0.4 1.3 8.1 -0.4 -0.1 -0.5 0.5 -1.3 -0.5 0.1 -1.1 -0.6 0.3 0.9 -0.6 0.4 2.7 1.0 -2.9 0.4
Alcohol intake frequency. 0.1 0.2 1.0 -0.1 -0.0 -0.5 -1.0 0.0 -0.3 -0.3 0.4 0.3 -0.3 -0.2 0.0 -0.4 -0.7 0.0 0.8 -0.4
Comparative height size at age 10 5.7 31.6 55.4 -7.4 5.8 4.9 6.9 4.8 2.9 -6.5 4.5 -7.3 -6.5 -5.2 -4.7 -4.6 -2.5 -6.1 -7.4 -4.3
Number of full sisters 0.1 0.2 0.6 -0.6 -0.2 -0.7 -0.5 -0.5 -0.1 -0.2 -0.4 0.1 -0.5 -0.2 0.0 0.1 0.3 0.4 -0.8 0.5
Suffer from ‘nerves’ 0.4 0.6 1.3 -1.0 1.1 1.0 0.1 1.1 -0.1 -0.7 0.3 -1.1 -0.6 -1.0 -0.9 -0.5 -1.0 -0.7 -0.0 -0.7
Overall health rating 0.8 1.7 3.6 -1.4 1.2 1.0 1.9 1.8 1.8 -1.2 0.5 -1.3 -1.2 -1.8 -0.9 -1.6 -0.7 -1.2 -1.0 -0.9
Chest pain or discomfort 0.2 0.3 1.7 -0.5 -0.5 -0.4 0.4 0.3 0.7 0.3 0.1 0.2 0.2 -0.4 1.0 0.1 -0.7 -0.2 1.3 0.3
Had major operations 0.7 0.8 2.1 -0.9 0.9 1.4 -0.0 0.9 -0.6 -1.0 0.3 -1.1 -1.0 -0.8 -1.2 -1.0 -0.7 -0.9 -0.8 -0.9
Age at last live birth 0.4 0.6 2.2 0.8 -0.6 -1.0 -1.1 -0.5 -0.2 0.8 -0.7 0.7 0.9 0.6 0.9 0.4 0.0 0.6 1.5 0.1
Family relationship satisfaction 0.8 1.0 2.0 0.5 -1.1 -1.2 -1.2 -1.0 0.1 1.1 -1.3 1.2 1.3 0.8 0.8 0.4 0.7 1.2 1.4 0.9
Leg pain on walking 0.3 0.4 2.7 0.2 0.0 0.1 -0.5 0.9 0.8 0.3 -0.1 0.6 0.5 -0.2 -0.1 -0.4 -0.7 0.1 1.6 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.0 -0.5 0.7 0.4 0.5 0.9 1.0 -0.5 0.2 -0.7 -0.3 -0.6 -0.7 -0.7 -0.4 -0.4 0.0 -0.7
Commuting to job workplace: Car/motor vehicle 0.4 0.4 1.4 -0.7 0.6 0.5 1.2 -0.6 -0.5 -0.5 0.0 -0.7 -0.5 -0.9 -0.5 -0.5 -0.1 -0.7 -0.7 -0.6
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 1.9 -0.6 0.2 0.1 -0.0 0.3 1.4 -0.8 1.1 -0.4 -1.0 -0.4 -0.4 -0.1 0.1 -0.3 -1.3 -0.4
Medication: Aspirin 0.7 0.9 2.7 -0.5 0.4 0.7 0.6 0.9 0.2 -1.1 1.6 -0.6 -1.6 -1.2 -0.6 -1.0 -1.1 -1.0 -0.9 -1.1
Supplements: Vitamin C 0.3 0.3 1.2 0.9 -0.5 -0.6 -0.5 -0.1 0.5 0.6 -0.0 1.1 0.7 0.5 0.2 -0.1 0.2 0.7 1.0 0.3
Knee pain experienced in last month 0.2 0.4 1.7 -0.7 0.5 0.5 -0.3 0.8 1.3 0.0 -0.1 -0.4 0.3 -0.8 -0.6 -0.4 -0.7 -0.5 0.9 -0.5
Hypertension (Self-reported) 2.1 5.9 8.4 -2.1 2.3 2.4 2.1 2.3 2.4 -2.4 2.6 -2.7 -2.6 -2.9 -2.3 -2.7 -2.7 -2.6 -1.5 -2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.0 3.1 -1.8 0.8 0.5 0.3 0.8 0.8 -1.1 0.5 -1.2 -1.3 -1.6 -0.5 -0.8 -0.7 -1.0 -1.2 -1.0
Illnesses of father: Heart disease 0.9 1.2 9.3 -0.1 -0.4 -0.2 -0.2 0.7 3.0 -0.1 1.0 1.1 -0.4 -0.4 1.0 0.1 -1.7 0.1 2.0 -0.1
Illnesses of siblings: Diabetes 0.2 0.2 2.0 0.5 0.1 0.5 1.4 0.2 0.5 0.2 -0.1 -0.0 0.2 -0.0 0.3 0.2 0.1 -0.3 0.1 -0.0
Smoking status: Previous 0.8 1.2 3.8 0.4 -1.1 -0.6 -2.0 -1.0 -1.9 0.9 -1.1 1.0 1.0 0.9 1.2 0.6 0.8 0.5 1.1 0.9
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.5 10.8 -2.8 2.5 2.3 3.3 1.5 1.2 -2.7 2.2 -3.1 -2.6 -2.0 -2.2 -1.7 -1.1 -2.3 -3.0 -2.0
Whole body fat-free mass 4.4 24.9 44.9 -6.1 5.3 5.1 6.7 4.4 2.1 -5.5 4.1 -6.3 -5.4 -4.8 -4.4 -4.1 -3.1 -5.8 -5.0 -4.6
Leg fat-free mass (right) 5.3 28.3 44.5 -6.7 5.7 5.3 6.4 4.5 2.7 -5.9 4.4 -6.7 -5.8 -5.3 -4.8 -4.8 -3.6 -6.3 -5.1 -4.9
Arm fat percentage (left) 6.4 25.7 34.3 -5.9 5.4 5.3 4.8 5.3 3.6 -5.6 4.7 -5.6 -5.5 -5.4 -4.8 -5.1 -4.2 -5.6 -3.8 -4.7
Average weekly red wine intake 0.4 0.6 3.3 0.1 0.8 0.9 -1.0 1.8 0.9 -0.3 -0.2 -0.9 0.1 0.3 -1.1 0.1 0.6 -0.3 -0.7 -0.7
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.1 -1.0 0.6 1.0 1.5 1.0 1.4 -0.6 0.7 -0.6 -0.6 -0.6 -0.4 -0.4 -0.8 -1.1 -0.0 -0.4
Mood swings 0.2 0.4 2.3 -1.4 -0.1 -0.3 0.1 -0.6 -0.2 -0.5 -0.2 -0.7 -0.5 -0.1 -0.1 -0.3 0.7 -0.0 -1.5 0.3
Loneliness, isolation 2.0 2.8 4.7 1.2 -1.6 -2.1 -1.0 -1.7 -2.2 1.8 -1.6 1.8 1.8 1.7 1.6 1.4 1.1 1.7 1.8 1.7
Long-standing illness, disability or infirmity 0.1 0.2 1.1 -0.1 -0.2 -0.6 0.6 0.1 -1.1 0.2 0.0 -0.2 0.1 -0.5 0.4 -0.5 -0.5 0.1 0.4 0.0
Ever had bowel cancer screening 0.4 0.4 3.1 -0.2 -0.7 -0.9 0.0 -0.5 -1.8 0.2 -0.2 0.4 -0.1 0.0 1.5 0.4 0.1 0.2 0.1 0.5
Diabetes diagnosed by doctor 0.5 0.8 2.7 -0.3 0.7 0.9 1.6 0.5 0.4 -0.7 1.2 -1.2 -0.7 -0.8 -0.7 -0.9 -0.2 -1.0 -1.0 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 2.3 2.4 5.3 -1.3 1.7 1.5 2.3 1.9 1.8 -1.6 2.0 -1.7 -1.2 -1.0 -1.4 -1.2 -1.0 -1.5 -0.8 -1.6
Friendships satisfaction 0.4 0.5 2.6 0.6 -0.8 -0.5 0.4 -0.2 0.0 0.8 -0.6 1.0 0.7 0.2 0.8 0.0 -0.3 0.6 1.6 0.4
Qualifications: nursing, teaching 1.7 2.6 5.4 -1.9 1.9 1.9 1.7 1.0 0.4 -1.9 1.7 -2.3 -1.7 -1.1 -1.2 -1.2 -0.8 -2.0 -2.0 -1.5
Commuting to job workplace: Walk 0.9 0.9 3.9 1.2 -1.2 -1.1 -2.0 -0.8 0.0 0.8 -0.1 1.1 0.7 1.1 0.9 0.9 0.8 1.1 0.3 0.5
Eye problems/disorders: Cataract 0.8 0.9 2.7 0.1 -1.0 -1.2 -1.2 -1.1 -0.9 0.8 -1.6 0.6 0.8 0.7 0.7 0.1 1.4 1.1 -0.2 0.8
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 2.9 1.6 -1.2 -1.3 -1.0 -1.6 -0.2 1.3 -0.6 1.7 1.3 1.4 0.8 1.0 0.8 1.2 1.2 0.8
Medication for cholesterol 0.9 1.4 2.6 1.2 -0.9 -1.1 -1.3 -0.9 -1.0 1.1 -1.1 1.4 1.2 1.6 1.0 1.6 1.1 1.2 0.8 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.0 2.3 3.7 -1.1 1.5 1.9 1.9 1.8 1.5 -1.4 1.6 -1.6 -1.4 -1.7 -1.4 -1.5 -1.8 -1.5 -0.5 -1.4
Back pain experienced in last month 0.3 0.5 3.0 -0.9 -0.0 -0.5 0.1 -0.6 -1.7 -0.3 -0.2 -0.6 -0.4 -0.2 0.0 -0.6 0.6 0.0 -1.5 0.6
Mineral and other dietary supplements 0.4 0.5 4.3 -0.0 0.1 0.3 -0.1 -0.0 1.7 0.2 0.1 0.8 0.4 -0.2 0.2 -0.1 -0.7 0.2 2.1 -0.5
Breast cancer (self-reported) 0.3 0.3 1.8 -1.4 0.6 0.6 -0.6 0.3 0.2 -0.6 0.3 -0.7 -0.4 -0.4 -0.1 -0.2 -0.8 -0.9 -0.0 -0.5
Asthma (self-reported) 0.4 0.9 2.4 -1.6 0.9 0.8 0.4 1.0 0.6 -0.9 0.4 -1.2 -0.7 -1.1 -0.8 -1.3 -0.7 -1.0 -0.5 -1.1
Osteoporosis (self-reported) 1.1 1.4 3.5 1.9 -1.1 -0.6 -0.9 -1.3 -0.8 1.4 -1.3 1.4 1.5 0.9 0.7 0.3 0.7 1.5 1.6 0.2
Osteoarthritis (self-reported) 0.3 0.4 2.8 -0.8 0.4 0.0 1.1 -0.3 0.3 -0.5 0.1 -1.0 -0.5 -0.6 -0.2 -0.5 0.6 -0.5 -1.7 -0.2
Medication: Aspirin 0.3 0.4 1.7 -0.3 0.0 0.3 0.4 0.5 0.1 -0.7 1.3 -0.4 -1.1 -0.9 -0.4 -0.7 -0.6 -0.6 -0.7 -0.6
Medication: Gliclazide 2.5 2.8 6.0 -0.7 1.4 2.2 2.0 1.4 0.9 -1.5 2.5 -1.7 -1.7 -1.7 -1.5 -1.8 -1.3 -2.0 -1.0 -2.1
Illnesses of father: None of the above (group 1) 0.5 0.7 4.1 0.6 -0.3 -0.1 0.8 -0.1 -2.0 0.6 -0.9 -0.2 0.5 0.8 -0.1 0.6 1.2 0.4 -0.8 1.1
Smoking status: Current 0.1 0.1 0.3 0.2 -0.1 -0.5 0.5 -0.0 -0.1 0.0 -0.0 0.4 0.1 -0.0 -0.1 -0.2 0.1 0.5 0.3 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.6 8.7 -2.4 2.4 2.3 3.0 2.1 0.8 -2.5 2.0 -2.6 -2.6 -2.7 -2.3 -2.1 -1.6 -2.5 -2.6 -2.5
Whole body water mass 4.0 23.1 42.4 -6.0 5.0 4.9 6.5 4.2 1.9 -5.3 3.9 -6.1 -5.2 -4.6 -4.2 -3.9 -2.9 -5.6 -4.9 -4.4
Leg predicted mass (right) 5.5 29.5 46.1 -6.8 5.8 5.5 6.5 4.6 2.8 -6.0 4.4 -6.8 -5.9 -5.4 -4.9 -4.8 -3.7 -6.4 -5.2 -5.0
Arm fat mass (left) 7.0 28.6 39.6 -6.3 5.7 5.6 5.6 5.5 3.6 -5.9 4.8 -6.1 -5.8 -5.5 -5.0 -5.1 -4.1 -6.1 -4.3 -5.0
Number of self-reported non-cancer illnesses 5.4 9.3 14.3 -3.4 3.2 2.8 3.0 3.0 0.1 -3.2 3.1 -3.7 -3.1 -3.5 -3.1 -3.8 -2.1 -3.1 -2.5 -3.2
Average weekly champagne plus white wine intake 0.6 0.9 6.0 1.2 -0.2 -0.5 -1.1 1.0 0.9 0.4 0.4 1.1 0.3 -0.2 0.4 -0.2 -1.4 0.4 2.4 -0.2
Miserableness 0.6 1.1 4.8 0.2 -0.9 -1.2 -0.1 -0.4 -2.2 0.9 -1.4 0.4 1.1 1.1 1.0 0.9 1.2 0.6 0.2 1.4
Guilty feelings 2.3 3.4 5.1 2.3 -2.1 -1.7 -1.7 -1.6 -1.5 2.3 -2.1 2.2 2.2 1.6 1.5 1.4 1.2 1.8 1.8 1.8
Wears glasses or contact lenses 2.3 2.7 6.8 1.5 -1.3 -1.5 -1.4 -1.7 -2.5 1.4 -1.9 1.1 1.6 2.1 1.0 1.4 2.6 1.8 -0.6 1.4
Ever taken oral contraceptive pill 1.0 1.1 2.7 0.9 -1.0 -0.9 -1.0 -0.3 0.6 1.2 -1.0 1.0 1.5 1.3 1.2 1.3 0.4 0.5 1.6 0.6
Hearing aid user 2.0 2.2 4.8 -1.8 1.6 1.7 1.1 1.5 0.0 -1.8 1.2 -1.7 -1.6 -1.4 -1.7 -2.2 -1.3 -1.5 -0.9 -1.4
Mother’s age at death 0.6 0.7 1.9 -0.8 1.1 0.8 0.9 1.4 0.1 -0.9 0.5 -0.3 -0.7 -0.7 -0.9 -0.6 -1.4 -0.6 0.9 -0.4
Financial situation satisfaction 0.1 0.2 0.8 -0.1 0.1 0.3 -0.1 0.7 0.2 0.0 -0.9 0.5 -0.0 -0.5 -0.4 -0.7 -0.4 -0.2 0.3 0.1
Tinnitus: Yes, now most or all of the time 0.5 0.6 2.0 -0.4 -0.4 -0.6 -0.7 -0.4 -1.3 0.2 -1.4 -0.2 0.3 0.5 0.6 0.3 1.4 0.4 -1.2 0.3
Commuting to job workplace: Public transport 0.3 0.4 1.0 -1.0 0.6 0.4 0.5 0.8 0.8 -0.6 0.6 -0.7 -0.7 -0.7 -0.1 -0.2 -0.6 -0.7 -0.2 -0.4
Eye problems/disorders: Glaucoma 3.2 3.8 7.4 2.7 -2.2 -2.0 -1.6 -0.8 -1.4 2.3 -1.4 2.0 2.4 1.8 2.5 1.9 1.3 2.1 2.2 1.4
Medication: Blood pressure 0.8 1.5 4.0 -1.2 0.9 1.1 2.0 0.9 0.6 -1.0 0.8 -1.4 -1.0 -1.7 -0.7 -1.8 -1.4 -1.3 -0.3 -1.2
Pain type(s) experienced in last month: Hip pain 1.3 1.6 4.1 -1.6 1.3 1.0 0.3 1.3 0.1 -1.0 0.6 -1.4 -0.6 -1.8 -1.2 -2.0 -1.7 -1.5 0.6 -1.4
Supplements: Fish oil (including cod liver oil) 1.3 1.6 6.9 -1.1 1.1 1.0 0.7 1.4 0.1 -1.4 1.4 -1.7 -1.7 -0.8 -1.3 -0.6 -0.4 -1.6 -2.6 -0.5
High cholesterol (Self-reported) 1.4 2.5 4.6 -1.7 1.4 1.7 2.1 2.0 0.2 -1.3 1.2 -1.4 -1.3 -2.0 -1.5 -2.1 -1.6 -1.5 -0.3 -1.8
Medication: Bendroflumethiazide 0.8 1.2 2.5 -1.3 0.6 0.9 1.1 0.6 0.3 -1.3 1.6 -1.2 -1.5 -1.2 -0.2 -1.3 -1.1 -1.1 -0.8 -1.1
Medication: Paracetamol 1.4 2.1 4.9 -2.2 1.5 1.2 1.5 1.7 -0.4 -1.7 1.1 -1.8 -1.6 -1.8 -1.0 -1.4 -1.1 -1.6 -1.1 -1.0
Medication: Lisinopril 0.2 0.2 0.9 -0.2 0.6 0.8 -0.1 0.5 0.3 -0.4 0.4 -0.9 -0.2 -0.1 -0.2 0.1 -0.0 -0.7 -0.6 -0.7
Medication: Atorvastatin 2.9 3.5 4.9 -2.1 1.9 2.0 2.2 1.5 -0.1 -2.1 1.9 -2.2 -2.0 -1.7 -1.7 -2.1 -0.7 -2.0 -2.1 -2.2
Illnesses of father: High blood pressure 0.1 0.1 0.3 -0.4 -0.2 -0.1 -0.5 -0.4 -0.5 -0.0 -0.1 0.2 -0.1 -0.1 0.3 -0.0 -0.4 -0.3 0.4 -0.2
Alcohol drinker status: Never 0.9 1.1 3.5 1.2 -0.9 -0.8 -1.1 -0.8 -0.8 1.3 -0.8 1.1 1.5 0.9 0.9 0.9 0.5 1.2 1.9 0.3
Ever smoked 0.6 1.0 2.8 0.8 -1.0 -1.1 -1.4 -0.5 -1.7 0.9 -0.8 1.0 1.1 1.0 0.9 0.4 1.0 0.9 0.9 1.2
Basal metabolic rate 5.3 29.4 48.0 -6.6 5.8 5.5 6.9 4.9 2.5 -6.0 4.5 -6.8 -5.9 -5.3 -4.8 -4.6 -3.5 -6.3 -5.3 -5.0
Leg fat percentage (left) 4.0 14.5 19.6 -4.2 4.1 4.1 4.1 4.4 2.8 -4.1 3.6 -3.9 -3.9 -3.8 -3.9 -3.8 -3.0 -4.0 -2.4 -3.8
Arm fat-free mass (left) 3.2 16.5 31.6 -5.2 4.1 4.1 5.6 3.8 1.8 -4.4 3.3 -5.0 -4.4 -4.0 -3.4 -3.1 -2.6 -4.8 -3.9 -3.6
Number of operations (self-reported) 1.5 2.2 4.5 -2.1 1.1 0.9 1.3 1.3 -1.2 -1.7 1.3 -1.9 -1.9 -1.8 -1.1 -1.6 -0.9 -1.2 -2.0 -1.0
Average weekly beer plus cider intake 1.9 2.8 6.3 1.2 -1.6 -1.4 -1.2 -2.5 -1.8 1.6 -1.8 0.7 1.4 1.9 1.5 2.1 2.4 1.6 -0.9 1.8
Irritability 2.9 4.9 11.4 -2.8 2.3 1.8 3.4 1.1 1.4 -2.3 1.7 -3.2 -2.0 -1.9 -2.1 -2.3 -0.7 -2.3 -2.8 -1.6
Risk taking 1.0 1.5 3.7 1.8 -1.6 -1.4 -0.8 -0.4 0.3 1.5 -0.5 1.9 1.4 1.1 1.1 0.5 0.6 1.4 1.7 0.6
Ever had prostate specific antigen (PSA) test 2.8 3.3 5.4 -2.0 2.0 1.4 1.8 1.6 -1.3 -2.0 2.1 -2.2 -1.7 -1.7 -1.6 -2.3 -1.4 -1.7 -1.1 -2.2
Fractured/broken bones in last 5 years 1.6 2.1 4.5 1.5 -1.3 -1.3 -1.5 -0.8 -0.6 1.7 -1.3 1.4 2.0 1.5 1.6 1.3 1.0 1.6 2.1 1.4
Age started oral contraceptive pill 0.3 0.3 1.4 0.3 -0.4 -0.7 -1.2 -0.2 0.1 0.2 -0.7 0.1 0.1 0.3 0.4 0.1 0.9 0.5 -1.1 0.6
Diastolic blood pressure, automated reading 0.9 2.9 6.1 -1.8 2.2 2.2 2.1 1.3 0.2 -1.6 0.4 -2.0 -1.2 -1.4 -2.5 -1.8 -0.1 -1.4 -2.2 -1.9
Ever depressed for a whole week 0.2 0.2 1.1 0.4 -0.4 -0.4 -0.1 0.6 0.5 0.4 -0.4 0.8 0.4 0.2 0.2 0.4 -0.3 0.2 1.0 0.3
Unable to work because of sickness or disability 0.5 0.6 1.4 0.8 -0.6 -0.5 -0.0 -0.6 -0.6 0.9 -1.2 0.1 1.1 0.8 1.1 1.0 1.0 0.8 0.1 1.0
Commuting to job workplace: Cycle 2.8 3.4 5.6 2.0 -2.3 -1.9 -2.1 -1.2 -0.7 2.0 -1.5 2.4 1.8 1.6 2.3 1.7 0.8 1.9 2.3 1.8
Myopia 0.5 0.7 2.1 -0.2 1.0 0.9 0.9 0.0 0.2 -0.5 0.7 -0.4 -0.2 -0.8 -1.4 -1.4 -1.1 -0.2 0.8 -1.0
Vascular/heart problems diagnosed by doctor 1.4 3.8 6.0 1.5 -1.8 -1.8 -1.8 -1.7 -2.2 1.9 -1.9 2.1 2.1 2.4 1.9 2.2 2.2 2.0 1.4 1.9
Cholesterol lowering medication 0.8 1.2 3.9 -0.8 0.7 1.2 2.0 0.9 1.2 -0.8 0.8 -1.5 -0.8 -1.3 -0.8 -1.2 -0.8 -1.1 -0.6 -1.1
Medication: Omeprazole (e.g. Zanprol) 4.9 6.0 8.6 -2.8 2.5 2.7 1.8 2.9 2.1 -2.8 2.5 -2.9 -2.7 -2.2 -2.5 -2.4 -1.5 -2.5 -2.4 -2.0
Pain experienced in last month 0.2 0.4 1.5 1.2 -0.2 0.1 -0.7 0.1 1.1 0.4 0.3 0.7 0.5 0.3 -0.3 0.2 0.0 0.5 1.0 -0.6
Supplements: Calcium 0.1 0.1 0.5 0.7 0.1 0.2 -0.3 -0.1 -0.2 0.4 -0.1 0.4 0.7 0.2 -0.4 -0.2 0.0 0.3 0.7 -0.4
Basal cell carcinoma (self-reported) 0.2 0.3 1.3 0.9 -0.5 -0.5 0.5 -0.1 -0.3 0.5 0.3 -0.0 0.2 0.4 0.7 1.1 -0.0 0.2 0.1 0.9
Heart attack/myocardial infarction (self-reported) 0.9 1.2 3.1 -1.6 1.0 0.9 1.4 0.7 0.8 -1.3 0.9 -1.3 -1.3 -0.8 -0.3 -0.9 0.2 -1.2 -1.8 -0.9
Deep venous thrombosis (DVT) (self-reported) 1.9 2.4 4.5 -1.5 1.7 1.6 1.2 1.3 0.1 -1.5 2.0 -1.4 -1.5 -1.7 -2.1 -2.0 -1.6 -1.6 -0.8 -1.6
Heart disease (siblings) 0.1 0.2 1.3 0.1 -0.4 -0.2 1.1 -0.0 -0.1 0.2 0.1 -0.2 0.3 0.2 0.9 0.4 0.6 -0.2 -0.2 0.2
Alcohol drinker status: Previous 0.6 0.7 1.7 0.6 -0.8 -1.0 -1.1 -1.2 -1.3 0.4 -0.5 0.7 0.1 0.9 0.9 1.2 0.6 0.7 -0.3 0.9
Pack years of smoking 2.6 3.9 7.0 -2.6 2.1 1.8 2.5 2.2 1.5 -2.0 1.5 -1.7 -1.9 -2.5 -1.8 -2.0 -2.5 -2.0 -0.3 -1.3
Impedance of whole body 0.1 0.8 8.3 -0.4 0.4 0.0 -0.3 0.0 -0.5 -0.7 -0.1 -0.8 -0.8 -0.1 -0.6 -0.4 1.2 0.2 -2.9 0.4
Leg fat mass (left) 7.0 27.4 37.0 -6.1 5.7 5.6 5.9 5.5 3.5 -5.7 4.8 -6.0 -5.4 -5.2 -5.0 -5.0 -3.9 -5.9 -3.9 -5.0
Arm predicted mass (left) 3.1 15.9 32.4 -5.0 4.0 4.0 5.7 3.8 1.8 -4.3 3.2 -4.9 -4.3 -3.9 -3.2 -3.1 -2.6 -4.7 -3.7 -3.5