Hub : Genes

FEZ2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1590	0.0330	2.8e-16	0.237	0.138	0.199	0.215	0.222	1.7e-28	1.6e-16	9.2e-24	9.8e-26	1.3e-26
2	GTEx	Brain Cerebellar Hemisphere	0.4070	0.0940	6.1e-05	0.295	NA	0.086	NA	0.276	2.7e-08	NA	3.2e-03	NA	8.6e-08
3	GTEx	Brain Cerebellum	0.4360	0.0920	4.3e-06	0.260	NA	0.170	NA	0.226	2.7e-08	NA	9.8e-06	NA	2.6e-07
4	GTEx	Spleen	0.4170	0.0950	3.1e-05	0.162	NA	0.170	NA	0.100	5.9e-05	NA	3.8e-05	NA	1.6e-03
5	GTEx	Whole Blood	0.1130	0.0310	1.1e-06	0.094	NA	0.104	NA	0.081	5.9e-09	NA	8.4e-10	NA	6.0e-08
6	NTR	Blood	0.0164	0.0070	6.6e-03	0.000	0.002	-0.001	0.004	0.002	4.2e-01	5.2e-02	9.7e-01	1.9e-02	5.9e-02
7	ROSMAP	Brain Pre-frontal Cortex	0.4123	0.0436	0.0e+00	0.549	0.496	0.579	0.572	0.585	1.1e-84	3.2e-73	7.3e-92	4.5e-90	3.1e-93
8	YFS	Blood	0.4005	0.0332	0.0e+00	0.515	0.511	0.537	0.551	0.537	7.3e-201	3.6e-198	3.1e-213	7.7e-222	1.7e-213
9	TCGA	Breast Invasive Carcinoma	0.0140	0.0079	1.1e-03	0.008	0.013	0.006	NA	0.006	6.4e-03	1.0e-03	1.5e-02	NA	1.4e-02
10	TCGA	Cervical Squamous Cell Carcinoma	0.0620	0.0370	3.1e-03	0.054	0.043	0.042	NA	0.044	1.1e-03	3.5e-03	3.7e-03	NA	3.3e-03
11	TCGA	Colon Adenocarcinoma	0.1100	0.0640	9.6e-05	0.034	0.071	0.058	NA	0.035	4.7e-03	6.1e-05	2.7e-04	NA	4.0e-03
12	TCGA	Esophageal Carcinoma	0.1090	0.0590	7.3e-03	0.011	0.021	-0.007	NA	-0.002	1.4e-01	7.1e-02	6.5e-01	NA	3.8e-01
13	TCGA	Head and Neck Squamous Cell Carcinoma	0.0434	0.0256	2.2e-03	0.004	0.016	0.008	NA	0.006	1.1e-01	6.1e-03	4.2e-02	NA	6.6e-02
14	TCGA	Brain Lower Grade Glioma	0.0770	0.0541	1.0e-03	0.013	0.024	0.025	NA	0.013	1.0e-02	7.8e-04	6.5e-04	NA	1.2e-02
15	TCGA	Prostate Adenocarcinoma	0.0637	0.0262	9.3e-09	0.050	0.078	0.071	NA	0.070	6.2e-06	1.4e-08	7.1e-08	NA	7.8e-08
16	TCGA	Testicular Germ Cell Tumors	0.1830	0.0700	1.8e-05	0.207	0.178	0.198	NA	0.211	7.6e-08	7.1e-07	1.5e-07	NA	5.3e-08
17	TCGA	Thyroid Carcinoma	0.0720	0.0350	2.3e-05	0.059	0.058	0.058	NA	0.056	2.0e-06	2.4e-06	2.7e-06	NA	3.8e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Bipolar Disorder (2018)	0.1	0.2	0.8	0.9	-0.0	-0.1	-0.1	-0.4	0.1	0.4	0.4	0.4	0.6	0.5	-0.0	-0.1	0.0	0.4	0.9	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.7	3.3	0.8	-0.7	-1.0	-1.8	-1.5	-0.4	0.5	-0.3	1.1	0.4	0.7	0.5	0.3	0.1	1.0	0.7	0.6
Depressed Affect (Nagel 2018)	0.3	0.6	3.5	-1.0	-0.1	-0.5	1.0	-0.6	-1.9	-0.1	-0.8	-0.7	0.1	0.3	0.3	-0.1	0.9	-0.1	-1.0	0.5
Depression (Nagel 2018)	0.6	0.9	2.7	0.6	-0.4	-1.0	-0.3	-1.4	-1.6	0.9	-0.9	0.3	1.4	1.1	0.5	0.2	1.1	1.0	1.1	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	3.7	-0.9	0.4	0.0	-0.1	0.2	0.7	-0.9	0.6	-1.2	-1.0	-0.2	-0.3	-0.8	0.3	-0.5	-1.9	-0.7
Neuroticism (Nagel 2018)	0.1	0.3	2.4	-0.7	0.2	0.1	1.0	-0.2	-1.6	-0.1	-0.7	-0.7	0.1	0.2	0.1	-0.3	0.5	-0.2	-0.6	0.2
Schizophrenia (2018)	0.4	0.9	5.0	0.4	-0.8	-1.3	-2.2	-1.5	-0.5	0.4	-0.7	1.1	0.0	0.5	0.7	0.5	0.1	1.0	0.2	1.1
Schizophrenia vs Biploar Disorder	1.0	1.3	3.0	0.8	-1.3	-1.6	-1.1	-1.6	-0.3	0.8	-1.0	1.6	0.5	1.0	1.5	1.2	0.4	1.2	0.4	1.7
Worry (Nagel 2018)	0.4	0.8	6.3	0.4	-0.2	-0.2	0.0	-0.4	-2.5	0.7	-1.2	0.0	1.1	1.2	0.4	0.6	1.1	0.7	0.2	0.2
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	-0.5	0.7	1.3	0.7	0.8	1.0	-0.6	0.6	-0.5	-0.5	-0.7	-0.5	-0.7	-1.1	-0.8	0.5	-0.8
Alzheimer’s Disease (in father)	0.6	0.6	3.5	1.2	-0.3	0.1	-1.2	-0.3	-0.1	0.7	-0.1	0.9	1.0	1.0	0.2	0.2	-0.2	0.8	1.9	0.0
Alzheimer’s Disease (including proxy)	0.1	0.1	0.9	-0.0	0.2	1.0	-0.5	0.5	0.3	-0.0	0.1	-0.1	0.1	0.1	-0.1	-0.0	-0.4	-0.2	0.7	-0.4
Crohns Disease (2017)	0.1	0.3	1.4	-0.3	0.4	0.1	-0.2	0.1	1.2	-0.2	0.0	0.1	-0.1	-0.7	-0.0	-0.6	-0.7	-0.5	0.9	-0.4
Irritable Bowel Disease (IBD)	0.1	0.3	1.4	0.5	0.1	-0.4	-0.7	-0.3	1.1	0.3	0.3	0.4	0.2	-0.4	0.0	-0.2	-0.6	0.1	1.2	-0.5
Ulcerative Colitis (UC)	0.2	0.3	0.9	0.1	0.4	0.1	-0.1	0.3	0.9	-0.1	0.9	-0.2	-0.1	-0.6	-0.4	-0.3	-0.9	-0.3	0.8	-1.0
Major Depression (MDD)	0.1	0.1	0.7	0.2	0.1	0.6	-0.8	0.2	-0.1	0.0	-0.2	0.2	0.0	0.2	-0.3	0.1	-0.3	0.1	0.3	-0.6
Reaction Time	0.4	0.8	7.3	0.3	0.1	0.1	-0.9	0.5	0.5	0.5	0.2	1.4	0.5	-0.2	-0.2	0.1	-1.3	0.3	2.7	-0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.8	0.2	-0.1	-0.4	0.6	-0.2	-0.6	0.1	-0.9	-0.3	0.2	0.8	0.2	0.4	1.5	0.3	-1.7	0.2
Breast Cancer	0.1	0.1	0.5	-0.7	-0.0	-0.1	-0.6	-0.0	-0.5	-0.3	0.5	-0.0	-0.4	-0.4	0.1	-0.4	-0.3	-0.1	0.0	0.1
Ovarian Cancer	0.4	0.6	1.7	-0.3	-0.8	-0.4	-0.6	-0.6	-1.0	0.6	-1.0	0.6	0.6	0.6	1.0	0.6	1.0	0.4	-0.0	1.3
Prostate Cancer	2.2	3.0	10.9	-2.4	1.6	1.6	3.3	1.6	0.2	-1.8	1.4	-1.9	-1.9	-1.8	-1.2	-1.3	-2.2	-1.6	-0.6	-1.0
Age at First Birth	0.8	1.2	3.8	-1.7	1.0	0.8	0.5	-0.1	0.7	-1.2	0.6	-1.9	-1.1	-0.8	-0.7	-0.7	0.2	-1.0	-2.0	-1.0
Bipolar Disorder (2011)	1.5	1.4	6.8	1.7	-0.8	-0.6	-1.9	-1.3	-0.5	1.3	-0.3	1.3	1.4	0.6	1.0	0.7	-0.2	0.8	2.6	-0.1
Body Mass Index (BMI) (2010)	3.4	4.6	6.5	-2.3	2.4	2.2	1.6	2.2	1.3	-2.4	2.4	-1.9	-2.5	-2.5	-2.0	-2.4	-2.5	-2.1	-0.8	-2.2
Coronary Artery Disease (CAD)	0.4	0.5	1.3	-1.1	0.5	0.8	0.7	0.7	1.0	-0.6	0.6	-0.3	-0.4	-0.8	-0.6	-0.8	-0.7	-0.6	0.7	-0.8
Crohns Disease (2012)	0.7	1.2	2.5	1.4	-1.0	-0.9	-0.7	-1.2	0.6	1.4	-1.4	1.3	1.4	0.6	0.9	0.6	0.5	0.9	1.6	1.1
Mean Putamen Volume	3.3	3.7	6.4	-1.9	2.3	1.8	0.7	1.3	0.8	-2.3	1.6	-2.2	-2.1	-2.2	-2.4	-2.5	-1.4	-1.8	-1.9	-2.3
Fasting Glucose	0.7	0.8	2.4	-0.3	0.8	1.3	1.0	1.5	0.4	-0.8	0.8	-0.5	-0.8	-1.0	-1.0	-1.3	-0.9	-1.1	-0.5	-0.5
HbA1C	0.1	0.1	0.4	0.6	-0.4	-0.4	-0.3	0.4	0.5	0.3	-0.1	0.6	0.2	0.3	0.3	0.0	-0.1	0.6	0.5	0.0
HDL Cholesterol	0.6	0.9	3.8	0.8	-0.1	-0.2	-1.5	-1.1	-0.3	0.4	-1.2	0.1	0.7	1.4	-0.4	0.7	1.9	0.7	-1.6	0.1
LDL Cholesterol	3.5	5.5	14.9	-2.4	2.3	1.9	3.2	1.5	1.0	-2.6	1.8	-2.9	-2.6	-2.0	-2.4	-2.5	-0.4	-2.1	-3.9	-2.0
Lupus	0.3	0.4	1.8	-0.7	0.5	0.4	-0.0	0.6	1.4	-0.6	0.1	-0.5	-0.9	-0.7	-0.6	0.1	-0.5	-0.6	-0.8	-0.1
Neuroticism (2016)	0.3	0.4	1.9	0.7	-0.5	-0.1	0.1	-0.4	-0.8	0.8	-0.4	0.9	1.1	0.7	0.0	-0.3	0.4	0.4	1.4	-0.0
Primary Biliary Cirrhosis	0.7	1.0	2.4	-0.2	0.7	1.0	1.3	1.4	1.3	-0.5	1.5	-0.1	-0.5	-0.8	-0.9	-0.6	-1.6	-0.7	1.1	-0.9
Rheumatoid Arthritis	1.5	2.0	5.0	-1.0	1.2	1.2	1.7	1.0	2.2	-1.2	1.6	-0.7	-1.4	-1.7	-1.6	-1.9	-1.7	-0.9	-0.2	-1.3
Schizophrenia (2014)	1.7	3.7	9.4	2.2	-1.9	-1.9	-3.1	-2.3	-0.5	1.8	-1.3	2.6	1.7	1.9	1.3	1.3	0.9	2.3	1.9	2.0
Triglycerides	0.5	0.7	2.4	-0.9	0.6	0.5	1.5	1.0	0.9	-0.7	1.0	-0.6	-0.9	-1.2	-0.5	-1.0	-0.8	-0.7	-0.2	-0.9
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.4	0.6	-0.4	-0.6	-1.2	0.6	0.1	0.4	1.0	0.7	0.3	-0.5	0.3	-0.3	-1.2	-0.0	0.7	-0.2
Ulcerative Colitis	0.2	0.3	1.6	0.7	0.1	-0.0	-0.7	-0.1	0.3	0.4	0.4	0.3	0.5	-0.3	-0.5	-0.5	-0.3	0.2	1.3	-1.0
Blood Eosinophil Count	0.4	3.1	6.6	-1.8	1.1	1.7	1.4	2.0	2.1	-1.7	1.9	-0.9	-1.9	-2.3	-0.9	-2.3	-2.6	-1.7	0.5	-1.5
Blood Platelet Count	0.5	5.3	12.4	2.6	-2.0	-2.4	-2.9	-2.6	0.1	2.7	-2.1	2.7	2.9	1.7	1.8	1.5	0.9	2.4	3.5	1.8
Blood Red Count	0.0	0.2	0.9	-0.9	0.2	0.3	-0.5	0.3	-0.4	-0.2	-0.1	0.0	-0.3	-0.7	-0.7	-0.6	-0.7	-0.3	-0.2	0.1
Blood White Count	0.0	0.3	1.6	-0.4	-0.0	-0.3	1.1	0.5	0.8	0.2	-0.1	0.1	0.2	-0.3	0.3	0.1	-0.6	-0.1	1.3	0.7
Heel T-Score	0.1	0.7	3.3	0.9	0.1	0.3	-0.4	0.8	1.8	-0.1	0.8	1.4	-0.5	-0.2	-0.6	-0.0	-1.4	0.2	1.3	-0.4
BMI	4.4	25.5	32.9	-5.1	5.5	5.7	5.7	5.3	4.5	-5.1	5.1	-5.2	-4.8	-5.2	-4.7	-5.0	-5.0	-5.7	-1.6	-5.6
Height	5.3	102.1	231.0	-12.7	10.7	9.4	10.6	7.3	3.2	-11.8	7.8	-13.5	-11.6	-9.2	-10.0	-8.8	-3.6	-10.6	-15.2	-8.0
Waist Hip Ratio (WHR)	0.6	2.5	5.3	-0.7	1.4	1.4	0.7	1.9	1.3	-1.4	2.2	-0.4	-1.4	-2.0	-2.1	-2.3	-2.2	-1.0	0.5	-1.9
Systolic Blood Pressure	0.5	2.5	5.2	-1.2	1.9	2.2	1.0	1.3	1.4	-1.2	1.1	-1.0	-1.2	-2.0	-2.1	-1.5	-2.3	-1.5	0.4	-1.9
Smoking Status	0.2	0.4	4.1	-0.2	-0.3	-0.5	-0.7	-0.4	-2.0	0.1	-0.3	0.2	0.2	0.1	0.3	-0.4	0.5	0.2	0.2	0.5
Allergy or Eczema	2.4	6.4	11.5	-2.6	2.8	3.4	2.8	2.5	0.7	-2.6	2.2	-2.5	-2.4	-2.8	-2.6	-2.7	-2.4	-2.9	-1.2	-2.6
Cardiovascular Disease	1.7	5.5	8.2	-2.0	2.6	2.8	2.2	2.3	1.8	-2.3	1.8	-2.9	-2.1	-2.4	-2.7	-2.5	-2.0	-2.5	-1.5	-2.7
Hypothyroidism (self reported)	0.3	0.6	5.4	0.3	-0.4	-0.2	-1.3	-0.3	-0.3	0.4	0.1	1.0	0.5	-0.4	0.6	-0.7	-0.9	0.4	2.3	-0.1
Respiratory disease	2.4	5.4	11.7	-3.4	2.4	2.4	2.5	1.7	0.9	-2.6	1.3	-3.2	-2.4	-2.5	-1.8	-2.4	-1.4	-2.8	-2.4	-2.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	0.5	0.5	0.8	0.8	0.5	1.0	-0.2	0.9	-0.6	0.0	-0.5	-0.6	-0.8	-0.1	-0.4	0.1	-1.2
Lung FEV1/FVC ratio	0.8	4.2	25.0	1.1	-0.4	-0.1	-0.7	2.0	3.4	0.5	1.0	3.0	-0.1	-1.7	-0.4	-1.2	-3.5	0.3	5.0	-1.4
Lung FVC	2.9	14.7	22.5	-4.7	3.8	3.5	3.8	2.4	0.8	-4.5	3.5	-4.7	-4.7	-4.3	-3.6	-4.0	-2.4	-4.2	-4.7	-3.1
Neuroticism	0.2	0.6	2.6	-0.3	0.6	0.5	1.6	-0.0	-1.4	-0.2	-0.2	-1.0	0.2	0.4	-0.9	-0.4	1.0	-0.2	-1.1	-0.6
Chronotype (morning person)	1.0	2.3	5.6	1.9	-1.7	-2.1	-1.8	-0.6	-0.8	1.6	-0.7	2.4	1.4	1.1	1.3	1.6	0.2	1.6	1.8	1.7
Hair Pigment	0.0	1.3	3.3	0.9	-1.2	-1.4	-0.9	-1.2	0.0	1.2	-1.8	1.1	1.1	0.6	1.1	0.5	1.4	1.6	0.1	1.4
Tanning	0.0	0.3	1.4	0.7	0.1	-0.3	-0.9	-0.3	0.8	0.1	0.4	0.8	0.2	0.1	-0.1	-0.5	-0.7	0.2	1.2	-0.0
Hand grip strength (left)	0.1	0.2	0.9	0.1	0.2	0.4	0.9	-0.1	-0.1	0.1	-0.3	-0.1	0.3	0.5	-0.6	0.3	0.6	-0.3	-0.2	0.0
Number of treatments/medications taken	2.1	3.8	5.4	-2.3	1.8	2.0	2.3	2.0	0.5	-2.0	2.1	-2.0	-2.0	-2.1	-2.1	-2.2	-1.4	-2.0	-1.3	-2.0
Average weekly spirits intake	0.7	0.8	2.1	-0.7	0.7	0.9	0.6	1.1	0.1	-0.8	1.2	-0.8	-0.8	-1.5	-1.0	-1.1	-1.1	-0.9	-0.0	-1.0
Sensitivity / hurt feelings	0.2	0.4	1.2	-0.6	0.4	0.7	0.9	0.7	0.3	-0.2	0.1	-0.4	-0.3	-1.1	-0.4	-0.8	-0.6	-1.0	-0.1	-0.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	4.3	1.1	-1.0	-1.5	-0.3	-1.4	-2.1	1.3	-1.1	1.0	1.6	1.3	0.9	0.4	0.9	1.4	1.4	1.0
Hearing difficulty/problems: Yes	2.0	3.0	11.3	0.8	-1.3	-1.7	-0.7	-2.1	-2.9	0.9	-1.9	0.1	0.9	1.8	1.0	1.1	3.4	1.4	-2.2	2.0
Relative age of first facial hair	0.2	0.4	3.1	-0.1	0.1	0.4	1.2	-0.2	-0.3	-0.2	-0.4	-0.9	-0.2	-0.1	-0.2	-0.1	1.0	-0.1	-1.7	-0.1
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	3.7	-0.3	-0.2	-0.1	1.4	-0.6	-1.9	-0.0	0.1	-0.8	-0.1	-0.4	0.7	-0.1	0.0	-0.3	-0.6	0.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.3	-0.7	0.6	0.1	0.4	0.6	-0.7	-0.6	0.1	-0.7	-0.8	-0.9	-0.7	-0.7	-0.3	-0.4	-1.1	-0.7
Ever had hysterectomy (womb removed)	0.3	0.3	2.0	0.1	-0.0	0.2	-0.7	0.3	1.4	-0.1	0.8	0.3	-0.3	-0.6	-0.3	-0.1	-1.2	-0.3	0.6	-0.5
Systolic blood pressure, automated reading	0.3	1.0	2.9	-0.6	1.3	1.7	0.7	1.2	1.0	-0.6	0.2	-0.5	-0.5	-1.1	-1.5	-0.7	-1.0	-0.9	0.1	-1.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	2.9	1.5	-1.2	-0.9	0.4	-1.5	-1.3	1.1	-0.8	0.4	0.9	1.0	1.3	1.2	1.7	1.0	-0.8	0.6
Angina	0.4	0.5	3.2	0.6	-0.4	-0.3	-0.2	0.2	1.0	0.3	0.2	1.0	0.2	-0.3	0.2	-0.4	-1.4	0.3	1.8	0.3
Medication for hormone replacement therapy	1.2	1.3	2.9	-1.3	1.2	0.9	1.2	0.2	-0.2	-1.3	1.1	-1.7	-1.2	-1.1	-1.0	-1.1	-0.3	-1.1	-1.7	-1.2
Vitamin and mineral supplements	0.3	0.4	1.3	-0.3	-0.5	-0.6	-1.2	-1.2	0.3	0.1	-0.8	0.1	-0.2	0.2	0.5	0.8	0.7	0.2	-0.7	0.6
Supplements: Zinc	0.2	0.2	1.1	0.1	0.3	0.5	-1.0	0.3	0.6	0.1	-0.2	0.3	0.3	0.1	-1.0	-0.7	0.0	0.4	0.2	-0.4
Medication: Co-codamol	0.2	0.3	0.9	0.1	-0.4	-0.7	-1.0	0.0	-0.8	0.4	-0.5	0.2	0.5	0.4	0.8	0.2	0.5	0.5	0.4	-0.0
Medication: Metformin	1.0	1.4	5.8	-0.8	0.8	0.8	2.4	0.6	-0.6	-1.0	1.2	-1.6	-1.2	-1.1	-0.8	-1.2	-0.2	-1.0	-1.8	-1.1
Diabetes (father)	0.4	0.5	1.7	0.7	-0.7	-0.8	-0.8	-0.6	0.1	0.8	-0.7	1.3	0.8	0.7	0.4	0.2	0.6	0.9	0.8	0.4
Diabetes (mother)	0.3	0.3	2.6	-0.4	0.2	0.7	1.0	0.1	0.2	-0.3	-0.2	-0.7	-0.4	-0.1	-0.1	-0.2	0.8	-0.3	-1.6	0.2
Severe depression (siblings)	0.6	0.6	1.4	1.1	-0.7	-0.7	-0.4	-1.1	-0.5	0.7	-0.6	0.8	0.9	1.2	0.4	0.3	1.1	1.0	0.4	0.3
Pack years adult smoking proportion	2.6	4.0	6.5	-2.5	2.2	1.9	2.4	2.3	1.9	-2.0	1.4	-1.7	-1.8	-2.5	-1.9	-2.1	-2.3	-2.0	-0.2	-1.4
Impedance of leg (right)	0.2	0.9	3.8	1.1	-0.6	-0.8	-0.7	-0.3	-1.1	0.4	-0.7	0.6	0.4	1.1	0.3	0.8	1.9	1.4	-1.4	1.0
Leg fat-free mass (left)	6.2	32.6	49.8	-6.9	6.1	5.8	6.9	5.0	3.1	-6.3	4.8	-7.1	-6.1	-5.7	-5.2	-5.2	-3.8	-6.6	-5.3	-5.4
Trunk fat percentage	8.6	34.4	49.4	-7.0	6.2	6.0	5.8	6.1	3.6	-6.6	5.3	-6.7	-6.6	-6.1	-5.3	-5.7	-4.3	-6.5	-5.4	-5.3
Hand grip strength (right)	0.1	0.3	1.3	-0.2	0.7	0.9	1.1	0.3	0.5	-0.1	-0.0	-0.5	0.3	-0.1	-1.0	-0.3	0.2	-0.7	0.2	-0.8
Townsend deprivation index at recruitment	1.4	2.0	5.7	1.2	-1.7	-1.6	-2.4	-1.6	-0.0	1.4	-0.8	1.3	1.2	1.4	1.5	1.9	1.3	1.7	0.6	0.9
Current tobacco smoking	0.1	0.1	0.9	-0.1	0.0	-0.5	0.9	0.0	-0.4	-0.1	-0.0	0.2	-0.1	-0.3	0.1	-0.3	0.1	0.3	0.1	0.4
Average weekly fortified wine intake	0.1	0.1	0.4	0.2	-0.4	-0.1	0.3	0.2	-0.4	0.3	-0.4	0.0	0.1	-0.1	0.6	0.3	-0.3	-0.2	0.6	0.3
Maternal smoking around birth	0.8	1.2	3.7	1.0	-0.7	-1.0	0.4	-1.0	-0.7	1.3	-1.9	0.7	1.6	1.2	0.7	0.8	1.9	1.3	0.2	0.5
Fed-up feelings	0.3	0.5	3.4	-1.0	0.3	0.3	1.8	-0.1	-0.5	-0.4	-0.0	-1.0	-0.3	-0.1	-0.6	-0.5	0.5	-0.5	-1.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	-0.1	-0.1	-0.5	0.4	-0.5	-0.9	0.5	-0.6	0.0	1.0	0.5	0.1	-0.4	0.5	0.5	0.9	0.0
Relative age voice broke	2.8	4.3	7.6	2.4	-2.8	-2.2	-1.0	-1.8	-2.0	2.2	-1.8	2.2	1.9	1.9	2.5	2.3	1.9	2.1	0.8	2.7
Taking other prescription medications	2.3	3.6	6.1	-2.2	1.9	2.1	1.9	2.5	0.9	-1.8	2.0	-2.1	-1.6	-2.1	-1.4	-2.2	-1.9	-2.0	-0.2	-2.3
Age when periods started (menarche)	0.5	1.1	4.5	-0.8	1.1	1.3	1.4	-0.3	0.0	-1.0	0.5	-1.5	-1.0	-0.6	-1.4	-0.6	0.1	-1.0	-2.1	-0.7
Bilateral oophorectomy (both ovaries removed)	6.1	7.0	11.3	-2.2	2.9	2.8	2.3	3.4	2.2	-2.6	3.0	-2.6	-2.4	-2.8	-2.8	-2.9	-2.7	-2.7	-1.1	-2.9
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.8	0.1	-0.2	0.1	0.9	0.4	0.8	-0.3	0.6	0.2	-0.7	-0.1	0.0	0.3	-0.4	-0.3	-0.2	0.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.2	0.3	-0.1	0.5	0.0	0.6	0.4	0.5	-0.5	0.5	0.5	-0.2	-0.2	-0.3	-0.4	0.0	1.1	0.1
Qualifications: CSEs or equivalent	0.8	1.0	2.5	-1.0	1.2	1.3	0.9	1.1	0.5	-0.8	0.4	-1.0	-0.4	-0.7	-1.6	-1.6	-0.7	-0.8	0.3	-1.3
Serious illness, injury or assault to yourself	0.2	0.2	0.7	0.2	0.6	0.7	0.9	0.4	-0.3	0.0	-0.5	-0.7	0.2	-0.0	-0.5	-0.4	0.3	-0.1	-0.5	0.1
High blood pressure	1.8	5.1	7.8	-1.9	2.1	2.1	2.0	2.0	2.3	-2.2	2.3	-2.4	-2.5	-2.8	-2.2	-2.5	-2.5	-2.4	-1.6	-2.2
Hayfever, allergic rhinitis or eczema	3.4	7.3	14.1	-2.8	3.0	3.8	2.7	2.7	0.9	-2.8	2.1	-2.6	-2.5	-3.1	-2.8	-3.0	-2.5	-3.2	-1.2	-3.0
Multivitamins +/- minerals	0.3	0.4	1.7	0.1	0.6	0.7	0.4	1.3	-0.4	-0.2	0.8	-0.4	-0.1	-0.2	-0.7	-0.8	-0.8	-0.4	0.2	-0.6
Stomach or abdominal pain in last month	0.5	0.6	1.3	0.4	-0.9	-1.1	-0.9	-0.6	-1.1	0.7	-0.4	0.8	0.6	0.4	1.0	0.6	-0.0	0.8	1.1	1.1
Supplements: Glucosamine	0.4	0.6	2.2	0.8	-0.5	-0.4	-0.0	-0.4	-1.5	0.5	-0.0	0.2	0.5	1.1	0.3	1.1	1.2	0.4	-0.9	0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	3.5	-0.6	0.7	0.5	0.9	0.6	-1.5	-0.7	0.4	-1.3	-0.5	-0.2	-0.6	-0.4	1.0	-0.7	-1.9	-0.9
Medication: Atenolol	0.5	0.7	1.4	-1.2	0.8	0.7	0.6	1.1	0.0	-0.8	0.4	-1.1	-0.7	-0.9	-0.1	-1.0	-1.1	-0.9	0.3	-0.9
Medication: Levothyroxine sodium	0.3	0.5	3.0	-0.1	-0.9	-0.5	-1.4	-0.1	-0.2	0.5	0.1	0.7	0.5	-0.1	1.1	-0.0	-0.6	0.0	1.7	0.5
Sitting height	3.3	23.7	54.3	-6.2	5.0	4.3	6.4	3.3	1.3	-5.5	3.5	-7.1	-5.5	-4.3	-3.7	-3.4	-1.5	-5.4	-7.4	-4.0
Chronic bronchitis/emphysema (father)	0.9	1.0	3.1	-0.8	1.4	0.7	-0.3	0.7	1.0	-0.8	0.3	-1.8	-0.4	-0.9	-1.3	-1.0	0.2	-1.0	-1.8	-1.1
High blood pressure (mother)	3.7	5.2	8.6	-2.8	2.2	2.5	2.1	1.8	1.8	-2.7	1.7	-2.9	-2.8	-2.2	-1.8	-1.8	-1.2	-2.7	-2.9	-2.0
Body mass index (BMI)	3.2	13.8	18.1	-4.2	4.0	4.0	3.8	4.1	2.9	-3.8	3.6	-3.8	-3.6	-4.0	-3.5	-3.8	-3.7	-4.2	-1.3	-3.9
Impedance of leg (left)	0.4	1.7	4.9	1.3	-1.2	-1.3	-1.1	-0.9	-1.5	0.9	-1.2	1.1	0.8	1.5	0.8	1.3	2.2	1.8	-1.2	1.6
Leg predicted mass (left)	6.2	32.7	49.8	-6.9	6.1	5.8	6.8	5.1	3.1	-6.3	4.8	-7.1	-6.1	-5.7	-5.2	-5.2	-3.8	-6.6	-5.4	-5.4
Trunk fat mass	9.7	41.5	58.8	-7.7	6.9	6.7	7.0	6.5	3.8	-7.2	5.7	-7.5	-7.1	-6.5	-5.9	-6.1	-4.5	-7.2	-6.0	-6.0
Waist circumference	7.4	26.9	35.8	-6.0	5.5	5.2	5.2	5.6	3.0	-5.6	5.1	-5.7	-5.5	-5.6	-5.1	-5.4	-4.5	-5.7	-3.4	-5.0
Number of incorrect matches in round	0.2	0.3	0.6	0.4	-0.7	-0.1	-0.6	-0.4	-0.1	0.4	0.4	0.8	0.3	0.5	0.8	0.7	-0.1	0.3	0.7	0.5
Past tobacco smoking	0.7	1.2	4.2	-0.5	1.1	0.9	2.0	0.8	1.8	-0.9	1.1	-1.0	-1.0	-1.0	-1.0	-0.6	-1.0	-0.8	-0.9	-1.2
Alcohol usually taken with meals	0.2	0.3	2.2	0.1	-0.4	-0.4	-1.5	0.1	-1.0	-0.0	0.1	0.3	-0.1	0.5	0.3	0.9	0.3	0.4	-0.4	0.6
Nervous feelings	0.6	1.1	2.7	1.6	-0.9	-0.9	-0.6	-0.2	-1.6	1.3	-1.2	0.8	1.4	1.1	0.8	1.0	0.9	1.1	0.9	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	4.7	0.6	-0.7	-1.0	-0.8	-0.2	-0.7	1.0	-0.7	0.9	1.4	0.7	0.6	-0.0	-0.1	0.9	2.2	0.9
Hearing difficulty/problems with background noise	3.2	5.1	8.6	2.2	-2.8	-2.6	-0.5	-2.4	-2.0	2.5	-2.5	1.8	2.4	2.2	2.9	1.9	2.5	2.1	0.9	2.8
Hair/balding pattern: Pattern 2	0.6	0.8	3.5	0.9	-0.5	-1.1	-1.1	-0.4	-1.9	0.7	-0.9	0.8	0.7	0.9	0.5	0.6	1.1	0.9	-0.1	0.6
Had menopause	0.4	0.5	1.3	-1.1	0.6	0.5	0.8	0.7	-0.4	-0.7	0.5	-0.8	-0.7	-0.9	-0.2	-0.5	-0.4	-0.6	-1.0	-0.4
Had other major operations	0.6	0.8	2.3	-0.8	0.5	0.3	-0.2	1.4	-0.7	-0.8	1.4	-0.4	-1.0	-1.4	-0.3	-0.5	-1.5	-0.8	0.3	-0.7
Forced vital capacity (FVC)	6.2	23.7	49.7	-6.0	5.2	4.6	6.0	3.0	0.8	-5.6	3.4	-6.7	-5.4	-4.6	-4.4	-4.5	-1.6	-5.4	-7.0	-3.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.7	0.9	-0.9	-0.6	0.2	0.3	0.7	0.6	-0.3	1.3	0.2	0.5	0.5	1.0	0.1	0.6	0.7	0.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.9	-1.0	1.2	1.0	1.2	1.2	-0.2	-1.1	1.1	-0.9	-1.0	-1.0	-1.4	-1.3	-1.1	-1.0	-0.3	-1.2
Qualifications: None of the above	0.2	0.5	1.0	0.3	-0.6	-0.8	-0.7	-1.0	-0.8	0.7	-1.0	0.5	0.6	0.2	0.9	0.7	0.8	0.7	0.2	0.7
Financial difficulties in last 2 years	3.7	4.9	7.1	-2.4	2.4	2.3	2.6	2.2	1.4	-2.4	2.0	-2.2	-2.4	-2.7	-1.9	-2.3	-2.5	-2.4	-1.0	-2.0
Mouth/teeth dental problems	0.1	0.1	0.3	0.6	-0.0	0.4	0.2	-0.2	0.2	-0.1	-0.1	-0.1	-0.4	-0.2	-0.4	0.2	-0.3	-0.2	-0.4	-0.2
Heart attack	0.7	0.8	2.3	-1.4	0.8	0.8	1.2	0.5	0.8	-1.0	0.7	-1.1	-1.1	-0.7	-0.2	-0.7	0.3	-1.0	-1.5	-0.7
Allergy	6.0	13.8	20.9	4.4	-4.1	-4.6	-3.7	-3.5	-1.8	3.9	-2.9	4.1	3.6	4.0	3.9	3.9	2.9	4.2	2.5	4.0
Pain all over the body in last month	1.2	1.3	3.2	-0.8	1.3	1.1	1.8	1.1	0.0	-1.2	0.9	-1.5	-1.2	-1.1	-0.5	-0.9	-0.4	-1.3	-1.5	-1.1
Diabetes (self-reported)	0.5	0.8	2.1	-0.6	0.7	1.0	1.4	0.5	0.3	-0.8	1.1	-1.2	-0.9	-0.8	-0.7	-0.7	-0.3	-1.0	-1.3	-1.0
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.4	-1.6	1.4	1.4	0.4	1.4	-0.3	-1.4	0.4	-1.7	-1.1	-1.0	-1.4	-0.9	-0.1	-1.3	-1.8	-1.3
Medication: Ramipril	0.2	0.3	2.6	0.0	-0.1	0.2	1.6	0.0	-0.1	-0.3	0.2	-0.0	-0.5	-0.6	0.0	-1.1	-0.0	-0.3	-0.4	-0.5
Medication: Simvastatin	1.5	2.2	4.1	-1.0	1.1	1.5	1.4	1.9	1.0	-1.2	1.6	-1.3	-1.4	-2.0	-1.2	-1.9	-1.8	-1.4	-0.1	-1.9
Fluid intelligence score	0.1	0.3	1.9	-0.3	0.1	-0.1	-0.2	-0.1	-1.4	-0.4	-0.3	-0.6	-0.5	0.0	0.5	0.2	0.4	-0.1	-1.4	-0.1
Illnesses of siblings	0.3	0.4	3.5	0.5	-0.0	-0.5	-1.9	-0.5	-0.5	0.3	-0.6	0.6	0.6	0.3	-0.5	-0.3	0.1	0.6	0.9	-0.1
Neuroticism score	0.2	0.3	1.8	-0.7	0.3	0.2	1.3	-0.0	-1.0	-0.1	-0.3	-0.7	0.2	0.1	-0.6	-0.3	0.6	-0.3	-0.7	0.0
Weight	8.0	39.5	58.3	-7.6	6.8	6.4	7.3	6.1	3.3	-6.9	5.4	-7.6	-6.7	-6.4	-5.8	-5.9	-4.4	-7.1	-5.5	-5.9
Impedance of arm (right)	0.9	4.3	23.6	-2.4	1.9	1.4	1.0	1.1	-0.4	-2.5	1.1	-2.9	-2.6	-1.6	-1.7	-1.8	0.2	-1.6	-4.9	-0.9
Arm fat percentage (right)	6.1	24.0	33.8	-5.8	5.2	5.1	4.7	5.2	3.2	-5.5	4.5	-5.6	-5.4	-5.1	-4.4	-4.7	-4.0	-5.6	-3.9	-4.5
Trunk fat-free mass	3.2	18.2	38.4	-5.2	4.5	4.3	6.2	3.7	1.4	-4.7	3.5	-5.5	-4.6	-3.9	-3.7	-3.2	-2.4	-4.9	-4.5	-3.9
Hip circumference	5.9	25.3	40.8	-6.2	5.4	5.1	5.2	5.0	2.4	-5.6	4.2	-6.4	-5.4	-5.0	-4.8	-4.9	-3.2	-5.7	-5.0	-4.5
Time employed in main current job	0.8	0.9	3.1	1.6	-0.9	-0.5	-1.3	-0.5	1.0	0.9	-0.0	1.8	0.7	0.8	-0.0	0.6	0.2	1.6	1.0	0.0
Alcohol intake versus 10 years previously	1.2	1.7	3.6	-1.3	1.4	0.8	1.9	1.1	0.7	-1.5	1.9	-1.3	-1.5	-1.5	-1.1	-1.3	-1.4	-1.2	-0.7	-1.1
Father’s age at death	0.4	0.6	4.8	0.4	0.2	0.0	-1.4	0.0	-2.2	0.3	-0.8	0.1	0.7	0.7	-0.6	0.3	0.6	0.4	0.1	-0.0
Worrier / anxious feelings	0.4	0.8	4.4	0.0	-0.8	-0.9	1.0	-0.7	-2.1	0.5	-0.8	0.1	0.5	0.8	1.1	0.5	0.9	0.4	-0.2	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.8	0.1	-0.5	-0.6	0.8	-0.2	-0.3	0.5	-0.6	0.3	0.7	0.2	0.3	0.1	0.3	0.6	0.9	0.2
Falls in the last year	0.7	0.9	2.7	0.7	-1.3	-1.6	-0.2	-0.5	-0.1	1.2	-1.1	0.8	1.1	0.4	1.6	0.5	0.7	0.9	0.8	1.0
Hair/balding pattern: Pattern 3	0.2	0.3	1.1	-0.7	0.0	-0.1	1.0	0.8	0.7	-0.5	0.5	-0.1	-0.7	-0.5	0.1	-0.5	-0.8	-0.5	-0.0	0.6
Number of live births	0.3	0.4	1.6	-0.7	0.8	0.4	0.3	0.5	-1.1	-0.6	-0.2	-0.5	-0.6	-0.7	-1.3	-0.8	-0.2	-0.0	-0.8	-0.6
Forced expiratory volume in 1-second (FEV1)	4.8	16.2	26.2	-4.7	4.4	3.9	5.1	3.2	1.3	-4.6	3.1	-4.8	-4.4	-4.3	-4.0	-4.2	-2.4	-4.3	-4.2	-3.7
Pulse rate	0.3	0.5	3.2	-0.3	0.5	0.1	0.8	-0.5	-0.5	-0.2	-0.4	-0.5	0.1	0.6	-1.0	0.1	1.4	0.4	-1.8	-0.2
Happiness	0.2	0.2	0.7	0.4	-0.1	-0.4	-0.2	-0.1	-0.8	0.2	-0.3	0.3	0.5	0.6	0.0	-0.4	0.4	0.7	0.7	-0.1
Noisy workplace	0.4	0.5	2.6	-0.4	0.7	0.6	0.1	0.9	0.3	-0.3	0.2	-0.6	-0.2	-1.1	-0.9	-1.6	-0.6	-0.7	0.0	-0.8
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.8	-0.1	0.3	0.2	-0.5	-0.5	-0.9	-0.1	-0.4	-0.3	0.1	0.4	-0.1	0.1	0.6	-0.2	-0.6	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	2.8	0.5	0.3	0.2	-0.3	0.4	-0.3	0.2	0.1	0.5	0.4	-0.1	-0.5	-0.8	-0.9	-0.1	1.7	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.7	1.5	-1.2	1.0	0.5	0.4	1.2	0.5	-0.7	0.6	-1.0	-0.4	-0.9	-0.5	-1.2	-0.7	-0.6	0.3	-1.2
Asthma	0.4	0.8	2.2	-1.5	0.8	0.8	0.8	1.0	0.4	-0.9	0.4	-1.2	-0.7	-1.0	-0.8	-1.3	-0.6	-1.0	-0.6	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.8	-0.6	0.5	0.0	0.6	0.1	-1.1	-0.1	-0.6	-1.0	0.2	0.2	-0.5	-0.1	1.4	-0.1	-1.1	-0.1
Medication: Cholesterol lowering	0.8	1.2	2.3	-1.1	0.9	0.8	0.9	1.2	-0.5	-1.2	1.5	-0.8	-1.5	-1.4	-0.7	-1.4	-1.0	-1.2	-0.8	-1.3
Depression (self-reported)	0.6	0.7	3.0	0.8	-0.2	-0.3	-1.7	-0.3	-1.7	0.6	-0.5	0.9	0.8	0.6	-0.4	-0.3	0.1	0.8	1.2	0.4
Medication: Lansoprazole	0.2	0.2	1.0	-0.4	0.1	-0.2	1.0	-0.4	-0.4	-0.4	0.2	-0.3	-0.6	-0.3	0.3	-0.1	-0.3	-0.1	-0.6	0.4
Prospective memory result	0.3	0.4	0.9	-0.7	0.6	0.3	-0.6	0.1	0.7	-0.5	0.7	-0.7	-0.4	-0.6	-0.5	-0.7	-0.2	-0.7	-0.4	-1.0
Lung cancer (father)	2.1	2.5	5.1	-2.3	1.8	1.5	1.4	1.8	0.7	-1.8	0.9	-1.9	-1.7	-1.7	-1.5	-1.4	-1.0	-1.6	-1.6	-1.4
Illnesses of mother	3.7	4.5	8.0	2.0	-2.1	-2.3	-2.3	-1.7	-1.4	2.4	-1.5	2.7	2.5	2.2	1.8	2.2	1.0	2.6	2.8	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	5.8	18.5	29.6	-4.9	4.7	4.2	5.4	3.5	1.5	-4.8	3.5	-5.1	-4.8	-4.6	-4.1	-4.4	-2.8	-4.7	-4.3	-4.0
Pulse wave Arterial Stiffness index	0.2	0.2	1.0	0.6	0.2	0.4	0.6	0.7	0.4	-0.2	0.3	0.2	-0.1	-0.0	-0.9	-1.0	0.1	0.3	-0.2	-0.5
Impedance of arm (left)	1.1	5.2	21.1	-2.5	2.4	1.9	1.0	1.4	0.4	-2.8	1.5	-3.0	-2.9	-2.1	-2.2	-2.4	-0.3	-1.9	-4.6	-1.3
Arm fat mass (right)	7.2	29.7	42.4	-6.5	5.8	5.7	5.9	5.6	3.5	-6.0	4.9	-6.4	-5.9	-5.6	-4.9	-5.0	-4.2	-6.3	-4.6	-5.0
Trunk predicted mass	3.2	18.2	38.3	-5.2	4.4	4.3	6.2	3.7	1.4	-4.7	3.5	-5.5	-4.6	-3.9	-3.7	-3.2	-2.4	-4.9	-4.5	-3.9
Standing height	4.3	43.0	98.0	-8.1	6.9	6.1	8.2	4.9	1.5	-7.5	4.8	-9.0	-7.4	-5.7	-5.8	-5.2	-2.0	-7.0	-9.9	-5.1
Length of working week for main job	1.5	1.6	3.3	-1.5	1.4	1.2	0.1	1.7	1.8	-1.3	1.4	-1.0	-1.1	-1.1	-1.3	-1.2	-1.1	-1.3	0.0	-1.8
Exposure to tobacco smoke at home	0.3	0.3	1.1	-0.3	0.6	0.9	-0.3	0.4	-0.5	-0.4	0.1	-0.1	-0.3	-0.6	-1.1	-0.9	-0.3	-0.4	0.1	-0.6
Breastfed as a baby	0.4	0.5	3.6	0.8	-0.2	-0.0	-1.9	0.4	-0.9	0.4	-0.6	0.5	0.7	0.8	-0.0	-0.2	0.4	0.6	0.8	-0.3
Tense / ‘highly strung’	0.1	0.2	1.2	0.9	-0.1	-0.0	0.1	-0.4	-1.1	0.5	-0.4	-0.2	0.8	0.4	0.3	-0.2	0.5	0.2	0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	9.0	-0.6	-0.5	-1.1	-1.6	-0.8	-3.0	-0.0	-0.4	-0.2	-0.3	0.2	0.8	0.3	0.7	0.1	-1.3	0.8
Hair/balding pattern: Pattern 4	0.2	0.4	2.3	0.2	-0.1	0.2	-0.1	0.0	1.5	0.7	-0.7	0.6	0.9	-0.2	-0.0	0.2	-0.0	0.1	1.5	-0.2
Birth weight of first child	3.1	5.5	20.2	-2.6	2.4	2.0	3.5	1.4	-0.7	-2.4	1.6	-3.6	-2.4	-1.3	-2.0	-1.6	0.0	-2.2	-4.5	-1.6
Peak expiratory flow (PEF)	2.9	6.6	13.8	-3.1	2.6	2.0	3.7	2.1	0.5	-2.9	2.3	-2.9	-3.0	-2.8	-2.2	-2.8	-1.8	-2.7	-2.8	-2.2
Pulse wave reflection index	1.3	1.6	3.7	1.9	-1.6	-1.1	-0.2	-1.0	-1.3	1.4	-1.0	1.4	1.3	1.5	1.3	0.8	1.4	1.2	0.4	1.6
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	-1.0	0.7	0.3	-0.2	0.7	0.3	-0.4	0.1	-0.9	-0.3	-0.7	-0.6	-0.6	-0.7	-0.8	-0.2	-0.8
Loud music exposure frequency	1.9	2.1	3.7	1.9	-1.7	-1.6	-1.6	-0.6	0.3	1.8	-1.0	1.9	1.6	1.5	1.2	1.4	0.7	1.4	1.8	1.3
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.8	0.2	-1.2	-1.1	-0.6	-1.2	-1.5	0.9	-1.7	0.5	0.8	1.5	1.0	1.5	1.5	1.1	-0.6	1.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.7	-0.3	-0.8	-0.7	0.3	-0.4	-1.2	0.6	-0.2	0.7	0.6	0.3	1.2	0.3	-0.1	0.3	1.3	1.1
Blood clot in the leg (DVT)	1.4	1.9	4.4	-1.3	1.5	1.4	1.1	1.2	-0.0	-1.3	1.6	-1.3	-1.2	-1.4	-2.1	-1.8	-1.2	-1.3	-0.9	-1.4
Medication: Paracetamol	1.7	2.9	4.3	-2.1	2.0	1.9	1.9	1.9	-0.1	-1.9	1.6	-1.6	-1.7	-1.9	-1.8	-2.0	-1.4	-1.8	-0.9	-1.4
Headache pain in last month	0.7	1.3	2.6	-1.5	1.3	1.6	1.2	0.9	-0.3	-1.1	1.0	-1.4	-0.8	-1.1	-1.3	-1.4	-0.9	-1.2	-0.4	-0.7
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.4	1.2	-1.1	-1.2	-1.2	-1.2	-0.5	1.6	-2.1	1.1	2.0	1.7	1.1	1.7	1.6	1.4	1.0	1.5
Glaucoma (self-reported)	2.0	2.4	5.7	1.9	-1.8	-1.8	-0.7	-0.7	-1.5	1.7	-1.0	1.7	1.6	1.1	2.4	1.7	0.8	1.7	1.7	1.4
Gout (self-reported)	0.4	0.6	1.8	-0.4	0.6	1.0	0.2	0.6	0.2	-0.7	0.7	-0.7	-0.6	-0.8	-0.9	-1.4	-0.5	-0.9	-0.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.4	-0.1	-0.3	-0.3	-1.5	-0.1	-0.5	0.1	0.3	0.4	0.2	-0.6	0.6	-0.8	-0.8	-0.0	1.6	-0.3
Medication: Amlodipine	0.3	0.5	3.1	0.7	-0.1	0.4	0.2	0.0	0.2	0.2	0.8	0.7	-0.0	-0.7	0.0	-0.6	-1.2	0.0	1.8	-0.5
Medication: Ventolin 100micrograms inhaler	1.6	2.1	5.3	-1.6	1.7	1.8	-0.1	1.8	1.0	-1.3	0.8	-1.3	-1.0	-1.6	-2.3	-1.5	-1.3	-1.5	-0.5	-1.7
Birth weight	0.9	1.9	8.6	-1.6	1.4	1.1	1.0	0.3	-0.4	-1.6	0.4	-2.3	-1.8	-1.2	-1.4	-0.8	0.1	-1.1	-2.9	-0.9
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.9	0.8	-0.1	-0.5	-0.0	0.3	0.1	0.5	0.3	0.6	0.5	0.1	0.2	0.2	-0.3	0.4	0.9	0.1
High blood pressure (siblings)	0.1	0.1	0.6	-0.2	-0.4	-0.1	0.8	0.2	0.4	0.1	-0.1	0.1	-0.3	-0.1	0.4	0.5	-0.0	-0.1	-0.4	0.6
Forced vital capacity (FVC), Best measure	6.9	25.2	46.8	-6.1	5.4	4.8	6.3	3.2	0.9	-5.7	3.8	-6.8	-5.6	-4.9	-4.4	-4.6	-2.2	-5.6	-6.8	-4.1
Body fat percentage	7.3	29.0	40.1	-6.3	5.7	5.6	5.4	5.8	3.5	-6.0	4.9	-6.1	-5.9	-5.6	-5.0	-5.3	-4.1	-6.0	-4.5	-5.0
Leg fat percentage (right)	4.5	16.2	22.3	-4.3	4.4	4.4	4.3	4.7	2.9	-4.3	3.9	-4.3	-4.0	-4.0	-4.1	-4.1	-3.1	-4.2	-2.7	-4.1
Arm fat-free mass (right)	3.8	19.4	37.2	-5.4	4.6	4.5	6.1	4.2	2.3	-4.8	3.8	-5.2	-4.7	-4.4	-3.8	-3.7	-3.0	-5.1	-3.7	-4.1
Exposure to tobacco smoke outside home	0.4	0.5	3.6	0.7	-0.6	-0.6	-0.6	0.2	0.1	0.4	0.7	0.8	0.4	0.6	0.9	0.5	-0.7	0.4	1.9	0.1
Comparative body size at age 10	1.0	2.6	10.4	1.4	-1.6	-2.0	-2.2	-0.7	1.5	1.7	-0.9	2.2	1.6	0.8	1.8	0.9	-0.6	1.3	3.2	0.8
Number of full brothers	3.5	4.4	8.5	2.0	-2.1	-2.3	-2.9	-2.1	-0.7	2.1	-2.0	2.1	2.1	2.4	1.9	2.4	2.3	2.5	0.9	1.8
Worry too long after embarrassment	0.2	0.3	1.1	-0.8	0.5	0.6	1.1	0.7	-0.4	-0.5	0.4	-0.2	-0.3	-0.3	-0.5	-0.7	-0.6	-0.7	0.5	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.6	-0.5	-0.6	-1.0	-1.6	-0.9	-1.2	0.3	-0.4	0.0	0.2	0.3	1.1	0.6	0.6	0.3	-0.2	0.7
Wheeze or whistling in the chest in last year	1.0	1.8	3.2	-1.8	1.4	1.8	1.2	1.6	-0.4	-1.2	1.0	-1.5	-0.9	-1.5	-1.3	-1.8	-1.1	-1.7	-0.3	-1.2
Number of children fathered	0.5	0.6	2.1	0.6	-0.7	-0.6	0.2	-0.7	0.0	0.9	-1.0	0.7	0.9	0.8	1.0	1.4	0.4	0.5	0.8	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	2.1	1.4	-0.7	-1.0	-0.4	-0.6	0.6	0.8	0.1	1.1	0.7	0.7	0.9	0.8	0.2	0.9	0.9	0.6
Age at first live birth	0.2	0.3	1.9	0.8	-0.1	0.0	-0.2	0.1	1.1	0.4	0.2	0.2	0.7	0.7	0.4	0.4	-0.2	-0.1	1.4	-0.3
Pulse wave peak to peak time	0.2	0.2	1.0	-1.0	0.2	-0.0	-0.1	-0.5	-0.4	-0.2	-0.0	-0.7	-0.3	-0.3	0.6	0.7	-0.2	-0.7	-0.3	0.2
Health satisfaction	0.4	0.6	1.8	-1.1	0.8	0.8	1.1	0.9	0.0	-0.6	-0.3	-0.4	-0.4	-0.9	-0.6	-1.3	-0.6	-0.5	0.4	-0.9
Shortness of breath walking on level ground	0.4	0.5	1.5	-0.1	0.6	0.9	0.8	0.9	0.6	0.0	-0.2	-0.4	0.5	-0.5	-0.7	-0.9	-0.6	-0.6	1.2	-0.8
Qualifications: College or University degree	1.4	4.4	7.5	-1.6	2.6	2.7	0.5	2.3	1.2	-2.4	2.7	-2.0	-2.3	-1.7	-2.6	-1.8	-1.6	-2.3	-1.6	-2.5
Eye problems/disorders: None of the above	1.1	1.3	2.2	-1.4	1.4	1.2	1.2	0.8	1.0	-1.4	1.0	-1.2	-1.3	-0.9	-1.2	-1.0	-0.8	-1.5	-1.0	-0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.6	0.6	-1.2	-1.6	-0.5	-0.7	-1.5	1.1	-1.3	1.2	1.1	0.8	1.4	0.2	0.9	1.4	0.5	1.2
Emphysema/chronic bronchitis	0.4	0.4	1.2	-0.7	-0.3	-0.4	-0.8	-0.9	0.7	0.2	-0.9	0.2	0.3	0.4	1.1	0.7	1.1	0.1	-0.3	0.5
Medication for pain relief, constipation, heartburn	3.2	5.5	8.2	2.7	-2.5	-2.3	-2.3	-2.6	-0.8	2.7	-2.5	2.4	2.6	2.5	2.6	2.9	1.7	2.3	1.6	2.3
Neck or shoulder pain in last month	1.2	1.7	4.0	0.6	-1.1	-1.3	-1.6	-1.9	-1.1	1.3	-2.0	0.7	1.5	1.4	1.3	1.2	1.6	1.3	0.2	1.1
Medication: Blood pressure	0.9	1.6	4.8	-0.5	0.9	0.9	0.9	0.7	1.0	-1.3	2.2	-0.8	-1.9	-1.5	-1.1	-1.3	-1.5	-1.2	-1.0	-1.4
Angina (self-reported)	0.3	0.4	2.4	0.6	-0.3	-0.3	-0.0	0.2	0.9	0.3	0.3	0.8	0.1	-0.3	0.1	-0.4	-1.3	0.2	1.5	0.3
Migraine (self-reported)	1.9	2.3	4.7	-1.9	1.5	1.6	1.4	1.3	-0.2	-1.5	1.8	-1.6	-1.6	-1.9	-1.4	-1.5	-2.2	-1.6	-0.5	-1.4
Medication: Ibuprofen	0.4	0.5	1.5	-0.9	0.6	0.1	0.4	0.3	-1.2	-0.3	-0.7	-1.1	-0.1	0.0	-0.5	0.0	1.0	-0.2	-1.2	-0.1
Medication: Allopurinol	0.9	1.2	2.8	-1.1	0.8	1.2	1.1	0.8	0.7	-1.2	1.3	-1.1	-1.3	-1.3	-0.7	-1.7	-1.3	-1.2	-0.3	-1.2
Medication: Omeprazole	2.8	3.4	7.0	-2.0	1.7	1.9	1.2	2.6	1.8	-2.0	1.9	-1.9	-1.8	-1.8	-1.9	-2.1	-1.6	-1.7	-1.1	-1.5
Medication: Seretide 50 evohaler	2.8	3.2	5.1	-2.2	1.7	1.6	2.2	2.1	0.9	-1.7	1.6	-1.9	-1.6	-2.2	-1.2	-1.8	-1.9	-2.3	-0.5	-1.8
Mean time to correctly identify matches	0.3	0.6	4.8	0.1	-0.1	0.0	-1.0	1.0	0.3	0.2	0.4	1.2	0.1	-0.4	0.3	-0.0	-1.4	-0.0	2.2	0.2
Heart disease (mother)	0.3	0.4	5.5	0.1	-0.0	0.2	-0.4	-0.4	2.4	-0.0	0.0	-0.2	-0.1	-0.6	0.3	-0.4	-0.3	-0.4	0.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.5	1.1	-1.0	-0.9	0.2	-1.2	-1.2	1.1	-0.9	0.5	1.1	0.9	1.2	0.7	1.1	0.9	0.1	1.2
Whole body fat mass	9.2	38.3	52.3	-7.2	6.6	6.5	6.7	6.3	3.8	-6.9	5.6	-7.1	-6.7	-6.2	-5.8	-5.9	-4.5	-6.9	-5.4	-5.8
Leg fat mass (right)	7.4	28.6	37.2	-6.0	5.8	5.8	6.0	5.7	3.6	-5.8	4.9	-6.1	-5.5	-5.3	-5.2	-5.2	-3.9	-5.9	-4.0	-5.2
Arm predicted mass (right)	3.6	18.4	34.5	-5.3	4.5	4.5	5.9	4.2	2.3	-4.7	3.6	-5.1	-4.6	-4.2	-3.7	-3.5	-2.9	-5.0	-3.7	-4.0
Pulse rate, automated reading	0.4	1.3	8.1	-0.4	-0.1	-0.5	0.5	-1.3	-0.5	0.1	-1.1	-0.6	0.3	0.9	-0.6	0.4	2.7	1.0	-2.9	0.4
Alcohol intake frequency.	0.1	0.2	1.0	-0.1	-0.0	-0.5	-1.0	0.0	-0.3	-0.3	0.4	0.3	-0.3	-0.2	0.0	-0.4	-0.7	0.0	0.8	-0.4
Comparative height size at age 10	5.7	31.6	55.4	-7.4	5.8	4.9	6.9	4.8	2.9	-6.5	4.5	-7.3	-6.5	-5.2	-4.7	-4.6	-2.5	-6.1	-7.4	-4.3
Number of full sisters	0.1	0.2	0.6	-0.6	-0.2	-0.7	-0.5	-0.5	-0.1	-0.2	-0.4	0.1	-0.5	-0.2	0.0	0.1	0.3	0.4	-0.8	0.5
Suffer from ‘nerves’	0.4	0.6	1.3	-1.0	1.1	1.0	0.1	1.1	-0.1	-0.7	0.3	-1.1	-0.6	-1.0	-0.9	-0.5	-1.0	-0.7	-0.0	-0.7
Overall health rating	0.8	1.7	3.6	-1.4	1.2	1.0	1.9	1.8	1.8	-1.2	0.5	-1.3	-1.2	-1.8	-0.9	-1.6	-0.7	-1.2	-1.0	-0.9
Chest pain or discomfort	0.2	0.3	1.7	-0.5	-0.5	-0.4	0.4	0.3	0.7	0.3	0.1	0.2	0.2	-0.4	1.0	0.1	-0.7	-0.2	1.3	0.3
Had major operations	0.7	0.8	2.1	-0.9	0.9	1.4	-0.0	0.9	-0.6	-1.0	0.3	-1.1	-1.0	-0.8	-1.2	-1.0	-0.7	-0.9	-0.8	-0.9
Age at last live birth	0.4	0.6	2.2	0.8	-0.6	-1.0	-1.1	-0.5	-0.2	0.8	-0.7	0.7	0.9	0.6	0.9	0.4	0.0	0.6	1.5	0.1
Family relationship satisfaction	0.8	1.0	2.0	0.5	-1.1	-1.2	-1.2	-1.0	0.1	1.1	-1.3	1.2	1.3	0.8	0.8	0.4	0.7	1.2	1.4	0.9
Leg pain on walking	0.3	0.4	2.7	0.2	0.0	0.1	-0.5	0.9	0.8	0.3	-0.1	0.6	0.5	-0.2	-0.1	-0.4	-0.7	0.1	1.6	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.0	-0.5	0.7	0.4	0.5	0.9	1.0	-0.5	0.2	-0.7	-0.3	-0.6	-0.7	-0.7	-0.4	-0.4	0.0	-0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.4	-0.7	0.6	0.5	1.2	-0.6	-0.5	-0.5	0.0	-0.7	-0.5	-0.9	-0.5	-0.5	-0.1	-0.7	-0.7	-0.6
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.9	-0.6	0.2	0.1	-0.0	0.3	1.4	-0.8	1.1	-0.4	-1.0	-0.4	-0.4	-0.1	0.1	-0.3	-1.3	-0.4
Medication: Aspirin	0.7	0.9	2.7	-0.5	0.4	0.7	0.6	0.9	0.2	-1.1	1.6	-0.6	-1.6	-1.2	-0.6	-1.0	-1.1	-1.0	-0.9	-1.1
Supplements: Vitamin C	0.3	0.3	1.2	0.9	-0.5	-0.6	-0.5	-0.1	0.5	0.6	-0.0	1.1	0.7	0.5	0.2	-0.1	0.2	0.7	1.0	0.3
Knee pain experienced in last month	0.2	0.4	1.7	-0.7	0.5	0.5	-0.3	0.8	1.3	0.0	-0.1	-0.4	0.3	-0.8	-0.6	-0.4	-0.7	-0.5	0.9	-0.5
Hypertension (Self-reported)	2.1	5.9	8.4	-2.1	2.3	2.4	2.1	2.3	2.4	-2.4	2.6	-2.7	-2.6	-2.9	-2.3	-2.7	-2.7	-2.6	-1.5	-2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	3.1	-1.8	0.8	0.5	0.3	0.8	0.8	-1.1	0.5	-1.2	-1.3	-1.6	-0.5	-0.8	-0.7	-1.0	-1.2	-1.0
Illnesses of father: Heart disease	0.9	1.2	9.3	-0.1	-0.4	-0.2	-0.2	0.7	3.0	-0.1	1.0	1.1	-0.4	-0.4	1.0	0.1	-1.7	0.1	2.0	-0.1
Illnesses of siblings: Diabetes	0.2	0.2	2.0	0.5	0.1	0.5	1.4	0.2	0.5	0.2	-0.1	-0.0	0.2	-0.0	0.3	0.2	0.1	-0.3	0.1	-0.0
Smoking status: Previous	0.8	1.2	3.8	0.4	-1.1	-0.6	-2.0	-1.0	-1.9	0.9	-1.1	1.0	1.0	0.9	1.2	0.6	0.8	0.5	1.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted	2.7	5.5	10.8	-2.8	2.5	2.3	3.3	1.5	1.2	-2.7	2.2	-3.1	-2.6	-2.0	-2.2	-1.7	-1.1	-2.3	-3.0	-2.0
Whole body fat-free mass	4.4	24.9	44.9	-6.1	5.3	5.1	6.7	4.4	2.1	-5.5	4.1	-6.3	-5.4	-4.8	-4.4	-4.1	-3.1	-5.8	-5.0	-4.6
Leg fat-free mass (right)	5.3	28.3	44.5	-6.7	5.7	5.3	6.4	4.5	2.7	-5.9	4.4	-6.7	-5.8	-5.3	-4.8	-4.8	-3.6	-6.3	-5.1	-4.9
Arm fat percentage (left)	6.4	25.7	34.3	-5.9	5.4	5.3	4.8	5.3	3.6	-5.6	4.7	-5.6	-5.5	-5.4	-4.8	-5.1	-4.2	-5.6	-3.8	-4.7
Average weekly red wine intake	0.4	0.6	3.3	0.1	0.8	0.9	-1.0	1.8	0.9	-0.3	-0.2	-0.9	0.1	0.3	-1.1	0.1	0.6	-0.3	-0.7	-0.7
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.1	-1.0	0.6	1.0	1.5	1.0	1.4	-0.6	0.7	-0.6	-0.6	-0.6	-0.4	-0.4	-0.8	-1.1	-0.0	-0.4
Mood swings	0.2	0.4	2.3	-1.4	-0.1	-0.3	0.1	-0.6	-0.2	-0.5	-0.2	-0.7	-0.5	-0.1	-0.1	-0.3	0.7	-0.0	-1.5	0.3
Loneliness, isolation	2.0	2.8	4.7	1.2	-1.6	-2.1	-1.0	-1.7	-2.2	1.8	-1.6	1.8	1.8	1.7	1.6	1.4	1.1	1.7	1.8	1.7
Long-standing illness, disability or infirmity	0.1	0.2	1.1	-0.1	-0.2	-0.6	0.6	0.1	-1.1	0.2	0.0	-0.2	0.1	-0.5	0.4	-0.5	-0.5	0.1	0.4	0.0
Ever had bowel cancer screening	0.4	0.4	3.1	-0.2	-0.7	-0.9	0.0	-0.5	-1.8	0.2	-0.2	0.4	-0.1	0.0	1.5	0.4	0.1	0.2	0.1	0.5
Diabetes diagnosed by doctor	0.5	0.8	2.7	-0.3	0.7	0.9	1.6	0.5	0.4	-0.7	1.2	-1.2	-0.7	-0.8	-0.7	-0.9	-0.2	-1.0	-1.0	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	2.3	2.4	5.3	-1.3	1.7	1.5	2.3	1.9	1.8	-1.6	2.0	-1.7	-1.2	-1.0	-1.4	-1.2	-1.0	-1.5	-0.8	-1.6
Friendships satisfaction	0.4	0.5	2.6	0.6	-0.8	-0.5	0.4	-0.2	0.0	0.8	-0.6	1.0	0.7	0.2	0.8	0.0	-0.3	0.6	1.6	0.4
Qualifications: nursing, teaching	1.7	2.6	5.4	-1.9	1.9	1.9	1.7	1.0	0.4	-1.9	1.7	-2.3	-1.7	-1.1	-1.2	-1.2	-0.8	-2.0	-2.0	-1.5
Commuting to job workplace: Walk	0.9	0.9	3.9	1.2	-1.2	-1.1	-2.0	-0.8	0.0	0.8	-0.1	1.1	0.7	1.1	0.9	0.9	0.8	1.1	0.3	0.5
Eye problems/disorders: Cataract	0.8	0.9	2.7	0.1	-1.0	-1.2	-1.2	-1.1	-0.9	0.8	-1.6	0.6	0.8	0.7	0.7	0.1	1.4	1.1	-0.2	0.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.9	1.6	-1.2	-1.3	-1.0	-1.6	-0.2	1.3	-0.6	1.7	1.3	1.4	0.8	1.0	0.8	1.2	1.2	0.8
Medication for cholesterol	0.9	1.4	2.6	1.2	-0.9	-1.1	-1.3	-0.9	-1.0	1.1	-1.1	1.4	1.2	1.6	1.0	1.6	1.1	1.2	0.8	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	3.7	-1.1	1.5	1.9	1.9	1.8	1.5	-1.4	1.6	-1.6	-1.4	-1.7	-1.4	-1.5	-1.8	-1.5	-0.5	-1.4
Back pain experienced in last month	0.3	0.5	3.0	-0.9	-0.0	-0.5	0.1	-0.6	-1.7	-0.3	-0.2	-0.6	-0.4	-0.2	0.0	-0.6	0.6	0.0	-1.5	0.6
Mineral and other dietary supplements	0.4	0.5	4.3	-0.0	0.1	0.3	-0.1	-0.0	1.7	0.2	0.1	0.8	0.4	-0.2	0.2	-0.1	-0.7	0.2	2.1	-0.5
Breast cancer (self-reported)	0.3	0.3	1.8	-1.4	0.6	0.6	-0.6	0.3	0.2	-0.6	0.3	-0.7	-0.4	-0.4	-0.1	-0.2	-0.8	-0.9	-0.0	-0.5
Asthma (self-reported)	0.4	0.9	2.4	-1.6	0.9	0.8	0.4	1.0	0.6	-0.9	0.4	-1.2	-0.7	-1.1	-0.8	-1.3	-0.7	-1.0	-0.5	-1.1
Osteoporosis (self-reported)	1.1	1.4	3.5	1.9	-1.1	-0.6	-0.9	-1.3	-0.8	1.4	-1.3	1.4	1.5	0.9	0.7	0.3	0.7	1.5	1.6	0.2
Osteoarthritis (self-reported)	0.3	0.4	2.8	-0.8	0.4	0.0	1.1	-0.3	0.3	-0.5	0.1	-1.0	-0.5	-0.6	-0.2	-0.5	0.6	-0.5	-1.7	-0.2
Medication: Aspirin	0.3	0.4	1.7	-0.3	0.0	0.3	0.4	0.5	0.1	-0.7	1.3	-0.4	-1.1	-0.9	-0.4	-0.7	-0.6	-0.6	-0.7	-0.6
Medication: Gliclazide	2.5	2.8	6.0	-0.7	1.4	2.2	2.0	1.4	0.9	-1.5	2.5	-1.7	-1.7	-1.7	-1.5	-1.8	-1.3	-2.0	-1.0	-2.1
Illnesses of father: None of the above (group 1)	0.5	0.7	4.1	0.6	-0.3	-0.1	0.8	-0.1	-2.0	0.6	-0.9	-0.2	0.5	0.8	-0.1	0.6	1.2	0.4	-0.8	1.1
Smoking status: Current	0.1	0.1	0.3	0.2	-0.1	-0.5	0.5	-0.0	-0.1	0.0	-0.0	0.4	0.1	-0.0	-0.1	-0.2	0.1	0.5	0.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.6	5.6	8.7	-2.4	2.4	2.3	3.0	2.1	0.8	-2.5	2.0	-2.6	-2.6	-2.7	-2.3	-2.1	-1.6	-2.5	-2.6	-2.5
Whole body water mass	4.0	23.1	42.4	-6.0	5.0	4.9	6.5	4.2	1.9	-5.3	3.9	-6.1	-5.2	-4.6	-4.2	-3.9	-2.9	-5.6	-4.9	-4.4
Leg predicted mass (right)	5.5	29.5	46.1	-6.8	5.8	5.5	6.5	4.6	2.8	-6.0	4.4	-6.8	-5.9	-5.4	-4.9	-4.8	-3.7	-6.4	-5.2	-5.0
Arm fat mass (left)	7.0	28.6	39.6	-6.3	5.7	5.6	5.6	5.5	3.6	-5.9	4.8	-6.1	-5.8	-5.5	-5.0	-5.1	-4.1	-6.1	-4.3	-5.0
Number of self-reported non-cancer illnesses	5.4	9.3	14.3	-3.4	3.2	2.8	3.0	3.0	0.1	-3.2	3.1	-3.7	-3.1	-3.5	-3.1	-3.8	-2.1	-3.1	-2.5	-3.2
Average weekly champagne plus white wine intake	0.6	0.9	6.0	1.2	-0.2	-0.5	-1.1	1.0	0.9	0.4	0.4	1.1	0.3	-0.2	0.4	-0.2	-1.4	0.4	2.4	-0.2
Miserableness	0.6	1.1	4.8	0.2	-0.9	-1.2	-0.1	-0.4	-2.2	0.9	-1.4	0.4	1.1	1.1	1.0	0.9	1.2	0.6	0.2	1.4
Guilty feelings	2.3	3.4	5.1	2.3	-2.1	-1.7	-1.7	-1.6	-1.5	2.3	-2.1	2.2	2.2	1.6	1.5	1.4	1.2	1.8	1.8	1.8
Wears glasses or contact lenses	2.3	2.7	6.8	1.5	-1.3	-1.5	-1.4	-1.7	-2.5	1.4	-1.9	1.1	1.6	2.1	1.0	1.4	2.6	1.8	-0.6	1.4
Ever taken oral contraceptive pill	1.0	1.1	2.7	0.9	-1.0	-0.9	-1.0	-0.3	0.6	1.2	-1.0	1.0	1.5	1.3	1.2	1.3	0.4	0.5	1.6	0.6
Hearing aid user	2.0	2.2	4.8	-1.8	1.6	1.7	1.1	1.5	0.0	-1.8	1.2	-1.7	-1.6	-1.4	-1.7	-2.2	-1.3	-1.5	-0.9	-1.4
Mother’s age at death	0.6	0.7	1.9	-0.8	1.1	0.8	0.9	1.4	0.1	-0.9	0.5	-0.3	-0.7	-0.7	-0.9	-0.6	-1.4	-0.6	0.9	-0.4
Financial situation satisfaction	0.1	0.2	0.8	-0.1	0.1	0.3	-0.1	0.7	0.2	0.0	-0.9	0.5	-0.0	-0.5	-0.4	-0.7	-0.4	-0.2	0.3	0.1
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.0	-0.4	-0.4	-0.6	-0.7	-0.4	-1.3	0.2	-1.4	-0.2	0.3	0.5	0.6	0.3	1.4	0.4	-1.2	0.3
Commuting to job workplace: Public transport	0.3	0.4	1.0	-1.0	0.6	0.4	0.5	0.8	0.8	-0.6	0.6	-0.7	-0.7	-0.7	-0.1	-0.2	-0.6	-0.7	-0.2	-0.4
Eye problems/disorders: Glaucoma	3.2	3.8	7.4	2.7	-2.2	-2.0	-1.6	-0.8	-1.4	2.3	-1.4	2.0	2.4	1.8	2.5	1.9	1.3	2.1	2.2	1.4
Medication: Blood pressure	0.8	1.5	4.0	-1.2	0.9	1.1	2.0	0.9	0.6	-1.0	0.8	-1.4	-1.0	-1.7	-0.7	-1.8	-1.4	-1.3	-0.3	-1.2
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.1	-1.6	1.3	1.0	0.3	1.3	0.1	-1.0	0.6	-1.4	-0.6	-1.8	-1.2	-2.0	-1.7	-1.5	0.6	-1.4
Supplements: Fish oil (including cod liver oil)	1.3	1.6	6.9	-1.1	1.1	1.0	0.7	1.4	0.1	-1.4	1.4	-1.7	-1.7	-0.8	-1.3	-0.6	-0.4	-1.6	-2.6	-0.5
High cholesterol (Self-reported)	1.4	2.5	4.6	-1.7	1.4	1.7	2.1	2.0	0.2	-1.3	1.2	-1.4	-1.3	-2.0	-1.5	-2.1	-1.6	-1.5	-0.3	-1.8
Medication: Bendroflumethiazide	0.8	1.2	2.5	-1.3	0.6	0.9	1.1	0.6	0.3	-1.3	1.6	-1.2	-1.5	-1.2	-0.2	-1.3	-1.1	-1.1	-0.8	-1.1
Medication: Paracetamol	1.4	2.1	4.9	-2.2	1.5	1.2	1.5	1.7	-0.4	-1.7	1.1	-1.8	-1.6	-1.8	-1.0	-1.4	-1.1	-1.6	-1.1	-1.0
Medication: Lisinopril	0.2	0.2	0.9	-0.2	0.6	0.8	-0.1	0.5	0.3	-0.4	0.4	-0.9	-0.2	-0.1	-0.2	0.1	-0.0	-0.7	-0.6	-0.7
Medication: Atorvastatin	2.9	3.5	4.9	-2.1	1.9	2.0	2.2	1.5	-0.1	-2.1	1.9	-2.2	-2.0	-1.7	-1.7	-2.1	-0.7	-2.0	-2.1	-2.2
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.4	-0.2	-0.1	-0.5	-0.4	-0.5	-0.0	-0.1	0.2	-0.1	-0.1	0.3	-0.0	-0.4	-0.3	0.4	-0.2
Alcohol drinker status: Never	0.9	1.1	3.5	1.2	-0.9	-0.8	-1.1	-0.8	-0.8	1.3	-0.8	1.1	1.5	0.9	0.9	0.9	0.5	1.2	1.9	0.3
Ever smoked	0.6	1.0	2.8	0.8	-1.0	-1.1	-1.4	-0.5	-1.7	0.9	-0.8	1.0	1.1	1.0	0.9	0.4	1.0	0.9	0.9	1.2
Basal metabolic rate	5.3	29.4	48.0	-6.6	5.8	5.5	6.9	4.9	2.5	-6.0	4.5	-6.8	-5.9	-5.3	-4.8	-4.6	-3.5	-6.3	-5.3	-5.0
Leg fat percentage (left)	4.0	14.5	19.6	-4.2	4.1	4.1	4.1	4.4	2.8	-4.1	3.6	-3.9	-3.9	-3.8	-3.9	-3.8	-3.0	-4.0	-2.4	-3.8
Arm fat-free mass (left)	3.2	16.5	31.6	-5.2	4.1	4.1	5.6	3.8	1.8	-4.4	3.3	-5.0	-4.4	-4.0	-3.4	-3.1	-2.6	-4.8	-3.9	-3.6
Number of operations (self-reported)	1.5	2.2	4.5	-2.1	1.1	0.9	1.3	1.3	-1.2	-1.7	1.3	-1.9	-1.9	-1.8	-1.1	-1.6	-0.9	-1.2	-2.0	-1.0
Average weekly beer plus cider intake	1.9	2.8	6.3	1.2	-1.6	-1.4	-1.2	-2.5	-1.8	1.6	-1.8	0.7	1.4	1.9	1.5	2.1	2.4	1.6	-0.9	1.8
Irritability	2.9	4.9	11.4	-2.8	2.3	1.8	3.4	1.1	1.4	-2.3	1.7	-3.2	-2.0	-1.9	-2.1	-2.3	-0.7	-2.3	-2.8	-1.6
Risk taking	1.0	1.5	3.7	1.8	-1.6	-1.4	-0.8	-0.4	0.3	1.5	-0.5	1.9	1.4	1.1	1.1	0.5	0.6	1.4	1.7	0.6
Ever had prostate specific antigen (PSA) test	2.8	3.3	5.4	-2.0	2.0	1.4	1.8	1.6	-1.3	-2.0	2.1	-2.2	-1.7	-1.7	-1.6	-2.3	-1.4	-1.7	-1.1	-2.2
Fractured/broken bones in last 5 years	1.6	2.1	4.5	1.5	-1.3	-1.3	-1.5	-0.8	-0.6	1.7	-1.3	1.4	2.0	1.5	1.6	1.3	1.0	1.6	2.1	1.4
Age started oral contraceptive pill	0.3	0.3	1.4	0.3	-0.4	-0.7	-1.2	-0.2	0.1	0.2	-0.7	0.1	0.1	0.3	0.4	0.1	0.9	0.5	-1.1	0.6
Diastolic blood pressure, automated reading	0.9	2.9	6.1	-1.8	2.2	2.2	2.1	1.3	0.2	-1.6	0.4	-2.0	-1.2	-1.4	-2.5	-1.8	-0.1	-1.4	-2.2	-1.9
Ever depressed for a whole week	0.2	0.2	1.1	0.4	-0.4	-0.4	-0.1	0.6	0.5	0.4	-0.4	0.8	0.4	0.2	0.2	0.4	-0.3	0.2	1.0	0.3
Unable to work because of sickness or disability	0.5	0.6	1.4	0.8	-0.6	-0.5	-0.0	-0.6	-0.6	0.9	-1.2	0.1	1.1	0.8	1.1	1.0	1.0	0.8	0.1	1.0
Commuting to job workplace: Cycle	2.8	3.4	5.6	2.0	-2.3	-1.9	-2.1	-1.2	-0.7	2.0	-1.5	2.4	1.8	1.6	2.3	1.7	0.8	1.9	2.3	1.8
Myopia	0.5	0.7	2.1	-0.2	1.0	0.9	0.9	0.0	0.2	-0.5	0.7	-0.4	-0.2	-0.8	-1.4	-1.4	-1.1	-0.2	0.8	-1.0
Vascular/heart problems diagnosed by doctor	1.4	3.8	6.0	1.5	-1.8	-1.8	-1.8	-1.7	-2.2	1.9	-1.9	2.1	2.1	2.4	1.9	2.2	2.2	2.0	1.4	1.9
Cholesterol lowering medication	0.8	1.2	3.9	-0.8	0.7	1.2	2.0	0.9	1.2	-0.8	0.8	-1.5	-0.8	-1.3	-0.8	-1.2	-0.8	-1.1	-0.6	-1.1
Medication: Omeprazole (e.g. Zanprol)	4.9	6.0	8.6	-2.8	2.5	2.7	1.8	2.9	2.1	-2.8	2.5	-2.9	-2.7	-2.2	-2.5	-2.4	-1.5	-2.5	-2.4	-2.0
Pain experienced in last month	0.2	0.4	1.5	1.2	-0.2	0.1	-0.7	0.1	1.1	0.4	0.3	0.7	0.5	0.3	-0.3	0.2	0.0	0.5	1.0	-0.6
Supplements: Calcium	0.1	0.1	0.5	0.7	0.1	0.2	-0.3	-0.1	-0.2	0.4	-0.1	0.4	0.7	0.2	-0.4	-0.2	0.0	0.3	0.7	-0.4
Basal cell carcinoma (self-reported)	0.2	0.3	1.3	0.9	-0.5	-0.5	0.5	-0.1	-0.3	0.5	0.3	-0.0	0.2	0.4	0.7	1.1	-0.0	0.2	0.1	0.9
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.1	-1.6	1.0	0.9	1.4	0.7	0.8	-1.3	0.9	-1.3	-1.3	-0.8	-0.3	-0.9	0.2	-1.2	-1.8	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.9	2.4	4.5	-1.5	1.7	1.6	1.2	1.3	0.1	-1.5	2.0	-1.4	-1.5	-1.7	-2.1	-2.0	-1.6	-1.6	-0.8	-1.6
Heart disease (siblings)	0.1	0.2	1.3	0.1	-0.4	-0.2	1.1	-0.0	-0.1	0.2	0.1	-0.2	0.3	0.2	0.9	0.4	0.6	-0.2	-0.2	0.2
Alcohol drinker status: Previous	0.6	0.7	1.7	0.6	-0.8	-1.0	-1.1	-1.2	-1.3	0.4	-0.5	0.7	0.1	0.9	0.9	1.2	0.6	0.7	-0.3	0.9
Pack years of smoking	2.6	3.9	7.0	-2.6	2.1	1.8	2.5	2.2	1.5	-2.0	1.5	-1.7	-1.9	-2.5	-1.8	-2.0	-2.5	-2.0	-0.3	-1.3
Impedance of whole body	0.1	0.8	8.3	-0.4	0.4	0.0	-0.3	0.0	-0.5	-0.7	-0.1	-0.8	-0.8	-0.1	-0.6	-0.4	1.2	0.2	-2.9	0.4
Leg fat mass (left)	7.0	27.4	37.0	-6.1	5.7	5.6	5.9	5.5	3.5	-5.7	4.8	-6.0	-5.4	-5.2	-5.0	-5.0	-3.9	-5.9	-3.9	-5.0
Arm predicted mass (left)	3.1	15.9	32.4	-5.0	4.0	4.0	5.7	3.8	1.8	-4.3	3.2	-4.9	-4.3	-3.9	-3.2	-3.1	-2.6	-4.7	-3.7	-3.5