Best TWAS P=1.57e-13 · Best GWAS P=8.56e-15 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C20orf26 | 0.20 | 0.17 | lasso | 6 | 0.18 | 4.9e-21 | -5.4 | 5.2 | 1.8e-07 | -0.06 | 0.05 | 0.95 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | INSM1 | 0.07 | 0.00 | bslmm | 522 | 0.02 | 2.2e-03 | 4.2 | 5.8 | 5.6e-09 | -0.01 | 0.08 | 0.15 | TRUE |
3 | CommonMind | Brain Pre-frontal Cortex | PLK1S1 | 0.08 | 0.01 | lasso | 3 | 0.04 | 1.1e-05 | 6.0 | 5.8 | 5.9e-09 | 0.82 | 0.02 | 0.98 | FALSE |
4 | GTEx | Artery Tibial | PLK1S1 | 0.07 | 0.08 | enet | 10 | 0.08 | 4.0e-07 | 7.6 | 7.4 | 1.6e-13 | 0.97 | 0.02 | 0.98 | TRUE |
5 | GTEx | Esophagus Mucosa | PLK1S1 | 0.11 | 0.11 | lasso | 5 | 0.09 | 7.8e-07 | 5.9 | 5.9 | 3.9e-09 | 0.83 | 0.11 | 0.89 | FALSE |
6 | GTEx | Heart Atrial Appendage | PLK1S1 | 0.15 | -0.01 | lasso | 4 | 0.00 | 6.1e-01 | 1.2 | 5.4 | 5.4e-08 | 0.56 | 0.05 | 0.41 | FALSE |
7 | GTEx | Skin Not Sun Exposed Suprapubic | PLK1S1 | 0.21 | 0.09 | lasso | 6 | 0.12 | 5.3e-07 | 7.3 | 6.3 | 3.8e-10 | 0.93 | 0.07 | 0.93 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | PLK1S1 | 0.15 | 0.13 | enet | 10 | 0.15 | 3.9e-12 | 6.0 | 5.4 | 7.6e-08 | 0.83 | 0.88 | 0.12 | FALSE |
9 | GTEx | Testis | PLK1S1 | 0.64 | 0.34 | enet | 33 | 0.39 | 1.0e-18 | 6.0 | 6.4 | 1.9e-10 | 0.79 | 0.67 | 0.33 | FALSE |
10 | GTEx | Whole Blood | PLK1S1 | 0.08 | 0.04 | enet | 9 | 0.02 | 4.0e-03 | 6.0 | 6.6 | 5.2e-11 | 0.89 | 0.06 | 0.94 | FALSE |
11 | YFS | Blood | CRNKL1 | 0.21 | 0.25 | enet | 18 | 0.27 | 2.3e-89 | -5.4 | -5.2 | 2.4e-07 | 0.03 | 0.03 | 0.97 | FALSE |
12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PLK1S1 | 0.05 | 0.07 | enet | 9 | 0.07 | 5.5e-15 | 5.8 | 6.4 | 1.7e-10 | 0.88 | 0.15 | 0.85 | FALSE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | PLK1S1 | 0.04 | 0.03 | blup | 64 | 0.04 | 4.0e-05 | 6.0 | 6.9 | 6.8e-12 | 0.88 | 0.11 | 0.88 | FALSE |
14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PLK1S1 | 0.09 | 0.02 | blup | 64 | 0.05 | 3.1e-03 | 6.0 | 6.8 | 7.4e-12 | 0.78 | 0.03 | 0.54 | FALSE |
15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PLK1S1 | 0.19 | 0.12 | enet | 14 | 0.13 | 4.3e-13 | 6.0 | 6.2 | 4.3e-10 | 0.80 | 0.86 | 0.14 | FALSE |
16 | The Cancer Genome Atlas | Thyroid Carcinoma | PLK1S1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 1.5e-04 | 6.0 | 6.1 | 1.0e-09 | 0.85 | 0.14 | 0.62 | FALSE |