TWAS hub - INSM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0290	1.1e-02	-0.002	0.015	0.011	0.019	0.000	8.9e-01	5.5e-03	1.4e-02	2.2e-03	3.2e-01
2	ROSMAP	Brain Pre-frontal Cortex	0.1879	0.0379	2.0e-09	0.105	0.094	0.135	0.134	0.136	2.3e-13	4.7e-12	6.0e-17	8.3e-17	4.4e-17
3	TCGA	Lung Adenocarcinoma	0.0348	0.0170	3.3e-03	0.009	0.017	0.005	NA	0.001	2.8e-02	3.7e-03	7.3e-02	NA	2.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Migraine (self-reported)	6.0	7.4	13.2	-2.9	-3.6	0.9
Neck or shoulder pain in last month	4.5	6.4	9.9	-2.3	-3.2	1.9
Average weekly champagne plus white wine intake	4.3	5.9	10.9	1.9	3.3	-1.8
Trunk fat-free mass	4.1	23.4	38.1	6.2	5.3	2.1
Trunk predicted mass	4.0	23.1	37.7	6.1	5.2	2.1
Arm predicted mass (right)	3.9	19.8	34.2	5.9	4.5	2.2
Age when periods started (menarche)	3.8	9.1	12.3	-3.5	-3.4	-1.8
Arm fat-free mass (right)	3.8	19.4	34.0	5.8	4.5	2.1
Sitting height	3.7	26.3	39.4	6.3	5.1	3.7
Arm fat-free mass (left)	3.7	18.9	29.5	5.4	4.8	1.9
Medication for cholesterol, blood pressure or diabetes	3.5	5.8	12.4	-3.5	-1.7	1.4
Whole body fat-free mass	3.5	20.2	33.6	5.8	4.8	2.1
Whole body water mass	3.5	20.1	33.8	5.8	4.7	2.1
Arm predicted mass (left)	3.4	17.4	28.6	5.3	4.3	2.2
Basal metabolic rate	3.3	18.1	30.2	5.5	4.5	1.9
Loud music exposure frequency	3.0	3.3	6.0	-2.4	-1.9	0.6
Chronic bronchitis/emphysema (mother)	2.9	3.3	7.8	2.8	0.6	1.3
Angina	2.8	3.6	7.2	2.7	1.9	0.5
Impedance of arm (right)	2.8	13.0	22.8	-4.8	-4.0	0.3
Time employed in main current job	2.8	3.2	7.1	2.7	1.4	0.8
Impedance of arm (left)	2.8	12.8	21.2	-4.6	-4.1	0.2
Commuting to job workplace: Cycle	2.8	3.4	6.0	2.0	2.4	-0.3
Angina (self-reported)	2.7	3.6	7.7	2.8	1.6	0.8
Leg fat-free mass (left)	2.6	13.9	24.5	5.0	3.8	1.6
Chronic bronchitis/emphysema (father)	2.6	3.1	4.3	-1.7	-2.1	1.5
Leg predicted mass (left)	2.6	13.8	24.4	4.9	3.8	1.7
Medication: Cholesterol lowering	2.6	4.0	8.0	2.8	1.0	-1.7
Relative age of first facial hair	2.5	5.2	10.7	-3.3	-2.2	0.5
Comparative body size at age 10	2.5	6.9	13.0	3.6	2.5	-1.2
Leg predicted mass (right)	2.5	13.2	23.8	4.9	3.7	1.4
Relative age voice broke	2.4	3.7	6.3	-2.5	-2.2	-0.2
Weight	2.4	11.8	20.1	4.5	3.7	1.1
Leg fat-free mass (right)	2.4	13.1	23.8	4.9	3.7	1.4
Long-standing illness, disability or infirmity	2.4	3.7	10.3	3.2	0.9	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	6.8	1.1	0.8	2.6
Medication: Atorvastatin	2.4	3.0	5.0	1.4	1.4	-2.2
Average weekly beer plus cider intake	2.4	3.5	4.8	-1.9	-2.2	1.4
Diabetes (self-reported)	2.3	3.5	6.9	2.6	1.4	-1.3
Medication: Omeprazole	2.3	2.8	6.2	0.4	-1.4	2.5
Ever had prostate specific antigen (PSA) test	2.3	2.7	4.5	2.1	1.8	0.5
Comparative height size at age 10	2.2	12.1	15.6	4.0	3.2	3.2
Eye problems/disorders: Glaucoma	2.2	2.6	4.8	1.3	2.2	-1.2
Impedance of whole body	2.2	11.0	17.7	-4.2	-3.9	0.8
Alcohol usually taken with meals	2.1	3.4	6.3	1.4	2.5	-1.4
Medication: Blood pressure	2.1	3.8	6.5	2.5	2.2	-0.4
Diabetes diagnosed by doctor	2.1	3.4	6.9	2.6	1.6	-0.8
Health satisfaction	2.0	2.6	6.0	1.3	0.3	2.4
Average weekly fortified wine intake	1.9	2.2	5.3	0.1	1.2	-2.3
Medication: Atenolol	1.9	2.3	5.2	1.0	2.3	0.9
Depression (self-reported)	1.9	2.2	3.9	-0.9	-1.4	-2.0
Eye problems/disorders: Cataract	1.9	2.2	5.3	0.2	1.1	-2.3
Illnesses of father: High blood pressure	1.9	2.4	6.0	-2.5	-1.0	0.1
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	4.7	0.1	-1.5	2.2
BMI	1.8	10.7	17.1	3.6	4.1	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	3.3	0.8	-1.8	1.8
Medication: Amlodipine	1.8	2.5	4.2	2.0	1.8	-0.3
Standing height	1.7	16.8	21.1	4.6	3.7	4.0
Number of full brothers	1.7	2.2	3.9	0.0	-1.6	2.0
Vitamin and mineral supplements	1.6	2.1	2.9	1.5	1.7	-1.1
Alcohol intake versus 10 years previously	1.6	2.4	3.3	1.1	-1.8	1.7
Exposure to tobacco smoke at home	1.6	1.8	3.7	1.2	-0.2	1.9
Illnesses of father: None of the above (group 1)	1.6	1.9	3.8	2.0	1.3	-0.4
Hearing aid user	1.6	1.8	4.0	2.0	0.6	1.1
Ever depressed for a whole week	1.6	2.0	3.4	1.8	1.0	1.3
Number of treatments/medications taken	1.5	2.8	7.7	2.8	0.1	0.7
Hip circumference	1.5	6.6	14.4	3.8	2.1	1.0
Leg fat mass (right)	1.5	5.8	11.3	3.4	2.4	0.3
Medication: Aspirin	1.5	2.0	3.6	1.9	1.3	0.9
Illnesses of siblings: Diabetes	1.5	1.9	3.0	1.6	-0.1	1.7
Asthma (self-reported)	1.5	2.9	5.8	-1.6	-2.4	-0.6
Depressed Affect (Nagel 2018)	1.4	2.9	6.4	0.3	-2.5	1.4
Height	1.4	26.1	47.2	6.9	2.7	4.9
Impedance of leg (right)	1.4	6.9	11.9	-3.4	-2.8	1.1
Impedance of leg (left)	1.4	6.7	10.7	-3.3	-2.9	0.9
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	3.1	1.0	-1.7	1.6
Falls in the last year	1.4	1.9	4.0	2.0	-0.8	1.0
Suffer from ‘nerves’	1.4	2.2	4.8	2.2	-1.2	0.6
Mood swings	1.4	2.5	5.1	-0.3	-2.3	1.5
Ever had bowel cancer screening	1.4	1.6	2.8	1.2	0.7	1.7
Osteoarthritis (self-reported)	1.4	1.9	4.1	2.0	-1.2	-0.3
Age started oral contraceptive pill	1.4	1.7	2.7	0.9	1.3	-1.6
Leg fat mass (left)	1.4	5.6	11.5	3.4	2.3	0.2
Allergy or Eczema	1.3	3.5	9.6	-0.8	-3.1	0.5
Chronotype (morning person)	1.3	3.0	6.4	1.4	2.5	0.9
Diabetes (mother)	1.3	1.7	3.1	1.8	1.4	-0.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	3.7	-0.9	-1.9	-0.5
Father’s age at death	1.3	1.8	3.8	0.8	1.9	-1.0
Number of live births	1.3	1.9	2.3	-1.5	-1.4	1.1
Age at last live birth	1.3	1.9	3.9	-0.1	1.3	-2.0
Commuting to job workplace: Car/motor vehicle	1.3	1.4	3.4	-1.8	0.2	-0.9
Medication for cholesterol	1.3	1.9	4.1	-1.2	0.5	-2.0
Fasting Glucose	1.2	1.4	3.3	0.3	-0.9	1.8
Type 2 Diabetes (T2D) (2018)	1.2	2.3	5.6	2.4	0.4	-1.0
Townsend deprivation index at recruitment	1.2	1.6	4.8	-0.3	0.1	-2.2
Serious illness, injury or assault to yourself	1.2	1.5	2.4	1.6	1.0	1.0
Multivitamins +/- minerals	1.2	1.5	2.6	-1.6	-1.3	0.5
Allergy	1.2	2.7	7.2	0.3	2.7	-0.9
Asthma	1.2	2.4	4.7	-1.4	-2.2	-0.6
Glaucoma (self-reported)	1.2	1.4	2.5	0.9	1.6	-0.8
Exposure to tobacco smoke outside home	1.2	1.5	2.2	-1.5	-1.5	0.5
Qualifications: College or University degree	1.2	3.7	7.3	-0.9	1.7	-2.7
Supplements: Vitamin C	1.2	1.4	2.9	-1.7	-1.1	-0.3
Risk taking	1.2	1.7	2.6	1.6	1.4	0.7
Fractured/broken bones in last 5 years	1.2	1.5	2.7	1.0	1.6	-0.9
Vascular/heart problems diagnosed by doctor	1.2	3.3	4.6	-2.2	-1.8	-1.5
Heart disease (siblings)	1.2	1.5	2.9	0.9	-0.8	1.7
Mean Putamen Volume	1.1	1.2	2.1	-1.5	-1.2	0.3
Supplements: Zinc	1.1	1.2	3.1	0.7	1.8	-0.4
Supplements: Glucosamine	1.1	1.5	2.0	-0.6	-1.4	1.4
Waist circumference	1.1	4.1	8.9	3.0	1.8	0.5
Heart attack	1.1	1.5	2.7	1.3	1.6	0.1
Medication: Simvastatin	1.1	1.6	3.6	1.9	-0.5	1.1
Medication: Lansoprazole	1.1	1.2	2.3	0.9	1.5	-0.6
Lung cancer (father)	1.1	1.3	3.2	1.8	0.3	0.7
Medication: Ventolin 100micrograms inhaler	1.1	1.4	2.3	-0.3	-1.4	-1.5
Wheeze or whistling in the chest in last year	1.1	2.0	2.8	-1.2	-1.7	1.3
Qualifications: nursing, teaching	1.1	1.7	2.4	0.8	1.5	-1.4
High cholesterol (Self-reported)	1.1	1.9	5.2	2.3	-0.3	-0.6
Medication: Lisinopril	1.1	1.4	3.7	0.4	0.6	-1.9
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.3	1.3	1.5	0.2
Body Mass Index (BMI) (2010)	1.0	1.4	3.7	0.7	1.9	0.2
Taking other prescription medications	1.0	1.6	4.4	2.1	0.0	0.6
High blood pressure	1.0	2.8	4.1	2.0	1.6	1.4
Hayfever, allergic rhinitis or eczema	1.0	2.2	5.3	0.1	-2.3	1.1
Body mass index (BMI)	1.0	4.1	7.2	2.7	2.2	-0.6
Trunk fat mass	1.0	4.4	9.2	3.0	1.8	1.0
Pain all over the body in last month	1.0	1.1	3.0	1.7	-0.0	0.5
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.1	-1.4	-1.2	-0.4
Mouth/teeth dental problems: Dentures	1.0	1.6	2.7	1.7	1.3	0.7
Prospective memory result	1.0	1.2	3.4	-0.4	-1.8	0.3
High blood pressure (siblings)	1.0	1.4	2.9	-1.1	-1.7	0.1
Whole body fat mass	1.0	4.2	8.3	2.9	1.9	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.6	-1.0	-1.3	0.9
Loneliness, isolation	1.0	1.3	2.4	1.0	-1.5	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.7	0.6	1.6	0.0
Medication: Aspirin	1.0	1.4	2.6	1.6	0.9	0.8
Alcohol drinker status: Never	1.0	1.2	1.9	1.4	1.3	-0.3
Cholesterol lowering medication	1.0	1.5	2.4	1.4	-0.5	1.5
Neuroticism (Nagel 2018)	0.9	2.1	5.7	0.7	-2.4	0.2
Reaction Time	0.9	1.6	3.0	1.4	0.3	-1.7
Ovarian Cancer	0.9	1.2	3.5	-1.9	0.0	0.0
Age at First Birth	0.9	1.3	2.9	-0.8	-1.7	0.5
Smoking Status	0.9	2.1	3.7	-0.7	-1.5	1.9
Lung FEV1/FVC ratio	0.9	4.4	10.1	-0.2	1.7	-3.2
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	1.7	-1.3	-0.8	-0.8
Qualifications: CSEs or equivalent	0.9	1.2	2.9	-0.6	-1.7	0.5
Stomach or abdominal pain in last month	0.9	1.2	2.4	1.0	1.6	-0.4
Hair/balding pattern: Pattern 2	0.9	1.2	1.7	-1.0	0.9	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.5	-0.2	-2.1	0.1
Pulse wave Arterial Stiffness index	0.9	1.1	2.0	1.1	-0.3	1.4
Arm fat mass (right)	0.9	3.6	6.4	2.5	2.1	-0.0
Eye problems/disorders: None of the above	0.9	1.0	1.8	-0.2	1.1	1.3
Medication: Ibuprofen	0.9	1.1	3.3	-0.2	-1.8	-0.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.0	-1.4	-1.1	0.2
Hypertension (Self-reported)	0.9	2.5	4.6	2.1	1.3	1.1
Average weekly red wine intake	0.9	1.3	2.7	1.1	1.6	0.0
Arm fat mass (left)	0.9	3.8	7.2	2.7	2.0	-0.3
Number of self-reported non-cancer illnesses	0.9	1.6	4.2	2.1	-0.6	-0.4
Medication: Blood pressure	0.9	1.7	3.4	1.0	0.8	1.9
Depression (Nagel 2018)	0.8	1.2	2.2	0.7	-1.0	1.5
Schizophrenia vs Biploar Disorder	0.8	1.1	3.1	0.2	0.4	-1.8
Ulcerative Colitis	0.8	1.1	1.5	-1.2	1.2	-0.6
Medication: Co-codamol	0.8	0.9	2.4	-0.5	-1.6	-0.1
Maternal smoking around birth	0.8	1.1	2.3	1.0	-0.1	1.5
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.5	1.6	0.6	0.4
Medication: Ramipril	0.8	1.0	1.8	1.3	0.9	0.7
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.7	-1.9	-0.7	-1.1
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	1.8	-0.6	1.4	-1.0
Age at first live birth	0.8	1.4	3.7	-0.6	0.4	-1.9
Medication for pain relief, constipation, heartburn	0.8	1.4	2.0	-1.4	-0.6	-1.3
Alcohol intake frequency.	0.8	1.8	5.1	2.3	-0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	2.7	0.2	1.6	-1.6
Miserableness	0.8	1.4	3.0	-0.6	-1.7	0.9
Ever taken oral contraceptive pill	0.8	0.9	2.1	-1.4	-0.9	0.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.1	-0.0	0.4	-1.8
Schizophrenia (2018)	0.7	1.4	3.9	-2.0	-0.0	0.4
Worry (Nagel 2018)	0.7	1.5	1.6	1.2	-1.2	-1.3
Alzheimer’s Disease (including proxy)	0.7	1.0	2.0	-0.1	1.4	-1.0
Crohns Disease (2012)	0.7	1.1	2.2	-1.0	0.5	1.5
Schizophrenia (2014)	0.7	1.5	4.1	-2.0	-0.5	0.4
Average weekly spirits intake	0.7	0.8	1.6	0.3	1.2	0.9
Diabetes (father)	0.7	0.8	1.6	-1.3	-0.6	0.8
Fed-up feelings	0.7	1.4	2.0	1.2	-1.4	0.9
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.5	1.2	-0.6	-0.8
Fluid intelligence score	0.7	1.4	2.9	-0.0	1.2	-1.7
Headache pain in last month	0.7	1.2	1.9	-1.4	-1.2	-0.1
Mean time to correctly identify matches	0.7	1.4	2.7	1.6	0.1	-1.2
Chest pain or discomfort	0.7	1.0	1.8	1.1	-0.1	1.3
Knee pain experienced in last month	0.7	1.0	3.0	0.4	-1.7	0.1
Smoking status: Previous	0.7	1.0	2.8	-0.2	-0.4	1.7
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.9	-0.9	-0.2	-1.4
Back pain experienced in last month	0.7	1.0	1.7	1.2	0.1	1.3
Breast cancer (self-reported)	0.7	0.9	2.3	0.2	1.5	-0.5
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.7	1.3	-0.4	0.9
Supplements: Calcium	0.7	0.8	2.0	0.5	0.5	1.4
Triglycerides	0.6	1.0	1.6	-1.3	-1.0	0.7
Cardiovascular Disease	0.6	2.0	3.6	1.9	1.5	-0.1
Respiratory disease	0.6	1.4	2.4	-0.7	-1.5	-1.2
Neuroticism	0.6	1.6	2.5	1.1	-1.6	-1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.7	1.3	-0.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.2	1.1	-1.0	-0.0
Nervous feelings	0.6	1.1	2.4	0.9	-1.6	0.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.5	-1.6	-0.6	-0.3
Blood clot in the leg (DVT)	0.6	0.8	2.4	-0.2	0.2	-1.6
Medication: Paracetamol	0.6	1.1	2.3	0.9	1.5	0.1
Number of children fathered	0.6	0.6	1.1	1.1	0.4	0.8
Medication: Allopurinol	0.6	0.8	1.5	1.2	0.8	0.6
Osteoporosis (self-reported)	0.6	0.8	1.5	0.3	-1.2	0.8
Medication: Gliclazide	0.6	0.7	1.7	1.3	-0.2	0.7
Leg fat percentage (left)	0.6	2.0	5.1	2.3	0.9	-0.2
Unable to work because of sickness or disability	0.6	0.7	1.2	1.0	0.3	1.1
Pain experienced in last month	0.6	1.0	2.1	-0.6	1.4	-0.8
Pack years of smoking	0.6	0.8	1.4	0.6	-0.9	1.2
Alzheimer’s Disease (in mother)	0.5	0.5	0.9	0.4	1.0	-0.7
Alzheimer’s Disease (in father)	0.5	0.5	1.0	-1.0	-0.6	0.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	-0.7	0.5	-1.6
HbA1C	0.5	0.5	1.0	-1.0	-0.8	0.1
Hand grip strength (left)	0.5	1.4	3.6	0.1	1.9	0.8
Medication for hormone replacement therapy	0.5	0.6	1.0	0.8	-0.2	-1.0
Medication: Metformin	0.5	0.7	1.9	1.4	-0.3	0.2
Financial difficulties in last 2 years	0.5	0.7	1.3	1.1	0.9	0.2
Neuroticism score	0.5	1.1	2.9	0.6	-1.7	0.2
Worrier / anxious feelings	0.5	1.0	1.8	0.8	0.8	-1.3
Hair/balding pattern: Pattern 3	0.5	0.7	1.8	1.4	0.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.4	-0.5	-1.2	-0.4
Leg fat percentage (right)	0.5	1.9	4.5	2.1	1.0	-0.2
Pulse wave peak to peak time	0.5	0.6	1.2	-0.8	0.3	-1.1
Emphysema/chronic bronchitis	0.5	0.5	1.5	-0.0	-1.2	-0.1
Illnesses of father: Heart disease	0.5	0.7	1.0	-1.0	-1.0	-0.0
Myopia	0.5	0.7	1.7	0.5	1.3	0.5
Bipolar Disorder or Schizophrenia	0.4	1.0	2.2	-1.5	0.2	0.9
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.8	-0.5	0.9	-1.7
HDL Cholesterol	0.4	0.7	1.3	-0.9	-0.0	-1.1
LDL Cholesterol	0.4	0.6	1.0	-0.2	1.0	-0.8
Hypothyroidism (self reported)	0.4	0.9	1.2	1.1	0.7	1.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.7	-0.2	-1.3	0.3
Hearing difficulty/problems: Yes	0.4	0.6	0.9	-0.9	-0.9	-0.2
Pack years adult smoking proportion	0.4	0.7	1.2	0.4	-0.8	1.1
Hand grip strength (right)	0.4	1.1	3.2	0.5	1.8	0.1
Current tobacco smoking	0.4	0.6	0.9	-0.8	-1.0	0.3
Past tobacco smoking	0.4	0.7	1.8	0.4	0.3	-1.3
Forced vital capacity (FVC)	0.4	1.6	2.4	0.9	1.6	1.3
Qualifications: None of the above	0.4	0.9	1.8	0.6	-1.4	0.7
Mouth/teeth dental problems	0.4	0.6	1.7	0.2	-1.3	0.2
Illnesses of siblings	0.4	0.5	1.0	0.0	1.0	-0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.6	0.7	1.9	-0.3
Pulse rate	0.4	0.6	1.4	0.5	1.2	0.5
Illnesses of mother	0.4	0.5	1.3	-0.4	-1.1	-0.3
Pulse wave reflection index	0.4	0.5	0.9	0.6	-1.0	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.4	1.2	0.0	0.1
Shortness of breath walking on level ground	0.4	0.5	0.7	0.8	-0.2	0.8
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	-1.1	-0.1	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	-0.3	-1.2	0.2
Overall health rating	0.4	0.8	1.0	0.9	-1.0	0.8
Had major operations	0.4	0.4	0.5	0.5	0.7	-0.7
Leg pain on walking	0.4	0.5	1.5	1.2	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.9	0.5	1.4	0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.5	-1.2	-0.4	-0.3
Guilty feelings	0.4	0.6	1.2	0.5	-1.1	-0.7
Wears glasses or contact lenses	0.4	0.5	1.0	0.7	-1.0	-0.1
Mother’s age at death	0.4	0.5	0.7	0.6	0.9	0.7
Irritability	0.4	0.7	1.4	-0.2	-1.2	0.8
Basal cell carcinoma (self-reported)	0.4	0.5	0.8	0.7	-0.9	-0.5
Ulcerative Colitis (UC)	0.3	0.5	1.3	-1.2	0.3	-0.2
Major Depression (MDD)	0.3	0.4	1.2	1.1	0.0	0.0
Prostate Cancer	0.3	0.4	0.7	-0.8	-0.6	0.5
Coronary Artery Disease (CAD)	0.3	0.4	0.9	-0.5	0.9	-0.3
Blood Platelet Count	0.3	3.3	3.7	-1.6	-1.9	-1.9
Waist Hip Ratio (WHR)	0.3	1.5	3.2	-0.7	-1.8	0.9
Systolic Blood Pressure	0.3	1.5	2.0	-1.4	-0.9	1.3
Sensitivity / hurt feelings	0.3	0.5	1.4	0.0	-0.4	-1.2
Number of incorrect matches in round	0.3	0.6	1.3	0.4	-0.5	1.1
Had other major operations	0.3	0.4	0.8	-0.9	0.2	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.6	0.5	-0.8	0.6
Breastfed as a baby	0.3	0.4	0.8	-0.3	0.9	-0.5
Hair/balding pattern: Pattern 4	0.3	0.6	1.3	-1.1	-0.7	-0.2
Peak expiratory flow (PEF)	0.3	0.7	1.5	-0.1	1.2	-0.8
Birth weight	0.3	0.6	1.6	-1.3	-0.3	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	0.3	-0.6	0.8
Smoking status: Current	0.3	0.4	0.7	-0.8	-0.8	0.1
Financial situation satisfaction	0.3	0.3	0.4	0.5	0.6	0.6
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.4	0.8	0.4
Medication: Paracetamol	0.3	0.4	0.7	0.4	0.6	0.8
Ever smoked	0.3	0.6	1.0	-0.8	-0.3	1.0
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.4	-0.4	0.9
Irritable Bowel Disease (IBD)	0.2	0.6	0.9	-0.7	1.0	-0.5
Bipolar Disorder (2011)	0.2	0.2	0.6	-0.1	0.8	0.1
Lupus	0.2	0.3	0.3	0.5	0.6	-0.5
Rheumatoid Arthritis	0.2	0.2	0.3	-0.6	-0.6	-0.3
Blood Eosinophil Count	0.2	1.2	1.3	-1.1	1.0	1.1
Blood White Count	0.2	1.2	1.3	1.2	1.1	-1.0
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.1	-0.6	-0.5
Severe depression (siblings)	0.2	0.3	0.5	0.2	0.5	-0.7
Trunk fat percentage	0.2	0.9	2.2	1.5	0.3	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.7	0.9	-0.2	0.6
High blood pressure (mother)	0.2	0.3	0.7	-0.8	-0.3	0.1
Hearing difficulty/problems with background noise	0.2	0.4	0.8	-0.0	-0.9	0.6
Arm fat percentage (right)	0.2	0.7	1.1	1.0	0.8	-0.6
Happiness	0.2	0.2	0.6	-0.8	-0.1	0.1
Noisy workplace	0.2	0.3	0.5	0.0	-0.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.4	0.1	1.2	-0.3
Length of working week for main job	0.2	0.2	0.4	0.1	0.6	0.4
Tense / ‘highly strung’	0.2	0.3	0.6	-0.2	-0.8	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.8	0.9	0.3	0.5
Birth weight of first child	0.2	0.4	0.6	0.4	0.8	-0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	0.9	0.0	0.5
Body fat percentage	0.2	0.8	2.0	1.4	0.6	0.3
Worry too long after embarrassment	0.2	0.4	0.8	-0.3	-0.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.1	0.6	-0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.5	-0.3	-0.6
Pulse rate, automated reading	0.2	0.7	0.9	0.9	0.9	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	0.2	-0.4	0.6
Friendships satisfaction	0.2	0.3	0.4	0.6	0.4	-0.6
Commuting to job workplace: Walk	0.2	0.2	0.5	0.7	-0.2	-0.1
Mineral and other dietary supplements	0.2	0.3	0.6	0.4	0.5	-0.7
Commuting to job workplace: Public transport	0.2	0.3	0.7	0.4	-0.2	0.8
Diastolic blood pressure, automated reading	0.2	0.7	1.3	-0.8	1.1	0.4
Alcohol drinker status: Previous	0.2	0.2	0.4	0.4	0.6	-0.3
Crohns Disease (2017)	0.1	0.3	0.9	-0.1	1.0	0.1
Breast Cancer	0.1	0.2	0.4	0.7	-0.4	-0.2
Neuroticism (2016)	0.1	0.1	0.2	0.4	-0.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	0.6	0.1	0.0
Heel T-Score	0.1	0.5	1.0	1.0	0.6	0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.5	-0.3	-0.2
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.1	-0.6	0.7
Medication: Levothyroxine sodium	0.1	0.2	0.4	-0.6	-0.0	0.3
Had menopause	0.1	0.2	0.2	0.5	-0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.3	-0.8	0.3
Gout (self-reported)	0.1	0.2	0.4	0.3	0.0	0.6
Forced vital capacity (FVC), Best measure	0.1	0.4	0.7	0.3	0.8	0.6
Heart disease (mother)	0.1	0.1	0.2	-0.2	-0.5	-0.1
Number of full sisters	0.1	0.2	0.4	0.1	0.6	-0.3
Family relationship satisfaction	0.1	0.1	0.3	0.3	-0.0	0.6
Arm fat percentage (left)	0.1	0.6	0.9	0.9	0.6	-0.8
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.2	0.2	0.5
Medication: Bendroflumethiazide	0.1	0.2	0.4	0.6	0.4	0.3
Number of operations (self-reported)	0.1	0.1	0.2	0.4	-0.4	0.3
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.0	0.1	-0.3
Blood Red Count	0.0	0.3	0.5	0.5	0.2	-0.7
Lung FVC	0.0	0.1	0.2	0.5	-0.3	0.1
Hair Pigment	0.0	1.1	2.4	-1.5	0.8	-0.6
Tanning	0.0	0.6	1.5	-0.0	1.2	0.3

Hub : Genes

INSM1

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Trait associations