TWAS hub - C20orf26

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2000	0.0330	2.6e-13	0.170	0.131	0.173	0.170	0.177	3.6e-20	1.3e-15	1.6e-20	3.5e-20	4.9e-21
2	ROSMAP	Brain Pre-frontal Cortex	0.0857	0.0282	7.9e-04	0.034	0.042	0.030	0.044	0.026	3.1e-05	3.7e-06	9.3e-05	2.0e-06	2.5e-04
3	TCGA	Breast Invasive Carcinoma	0.0292	0.0135	2.8e-03	0.020	0.017	0.012	NA	0.016	5.1e-05	1.3e-04	1.2e-03	NA	2.8e-04
4	TCGA	Brain Lower Grade Glioma	0.0416	0.0189	4.7e-03	0.015	0.008	0.007	NA	0.009	6.1e-03	4.1e-02	4.6e-02	NA	2.6e-02
5	TCGA	Thyroid Carcinoma	0.0700	0.0320	9.3e-03	0.016	0.007	0.038	NA	0.033	1.0e-02	5.6e-02	1.2e-04	NA	3.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Handedness (chirality/laterality): Left-handed	5.7	6.8	12.0	-3.5	-2.6	-2.6	-1.7	-2.4
Smoking status: Previous	4.6	6.9	13.4	-1.8	-3.7	-2.7	-2.5	-2.1
Past tobacco smoking	4.5	8.2	16.2	2.0	4.0	2.9	2.7	2.2
Illnesses of father: None of the above (group 1)	4.4	5.4	9.9	3.1	1.7	2.7	2.0	1.7
Commuting to job workplace: Car/motor vehicle	3.6	4.1	6.4	-1.1	-2.1	-2.2	-2.5	-1.9
Ever smoked	3.6	6.4	12.4	-2.0	-3.5	-2.2	-2.1	-2.4
Eye problems/disorders: Diabetes related eye disease	3.5	3.8	7.1	2.7	2.5	2.4	0.3	-0.4
Time employed in main current job	3.4	4.0	5.9	2.1	2.4	1.6	2.0	1.6
Relative age voice broke	3.2	4.8	11.6	-2.1	-1.3	-3.4	-2.3	-1.1
Taking other prescription medications	3.2	5.0	11.2	-1.1	-3.3	-1.8	-2.3	-2.0
Illnesses of father: Heart disease	3.1	4.2	6.3	-2.3	-1.7	-2.5	-2.2	-1.3
Blood Eosinophil Count	2.8	21.8	37.0	-5.0	-4.0	-6.1	-5.0	-2.4
Mean Putamen Volume	2.6	3.0	7.6	-0.6	-2.2	-1.4	-2.7	-0.5
Relative age of first facial hair	2.6	5.4	12.5	-2.6	-2.0	-3.5	-1.8	-0.6
Had other major operations	2.5	3.1	8.5	-1.4	-2.9	-0.7	0.1	-2.1
Smoking Status	2.3	5.4	8.5	-1.3	-2.9	-2.4	-2.9	-1.7
Trunk fat-free mass	2.3	13.3	38.7	6.2	0.4	3.8	-2.3	2.9
Trunk predicted mass	2.3	13.3	38.3	6.2	0.4	3.7	-2.4	2.9
Medication for cholesterol	2.1	3.1	8.8	0.5	0.9	2.2	3.0	1.0
Number of self-reported non-cancer illnesses	2.1	3.7	9.3	-0.8	-1.7	-2.2	-3.1	-0.8
Illnesses of father: High blood pressure	2.1	2.6	6.2	-2.4	-2.5	-1.0	-0.3	0.6
Reaction Time	2.0	3.8	8.2	2.9	1.9	2.2	1.2	0.8
Pulse wave reflection index	2.0	2.4	5.1	1.1	-0.2	2.1	1.1	2.3
Medication: Atenolol	1.9	2.3	4.8	-2.2	-0.3	-1.6	0.1	-2.0
Arm fat-free mass (right)	1.9	9.7	27.2	5.2	-0.2	2.5	-3.0	2.5
Neck or shoulder pain in last month	1.9	2.7	6.2	-1.1	-1.8	-2.5	-1.5	-0.9
Arm predicted mass (right)	1.9	9.8	28.3	5.3	-0.1	2.6	-2.7	2.6
Whole body fat-free mass	1.9	10.8	30.6	5.5	0.1	3.1	-2.7	2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.0	7.6	1.7	1.7	2.8	1.6	2.0
Whole body water mass	1.9	10.6	29.7	5.5	0.0	3.1	-2.7	2.5
Commuting to job workplace: Cycle	1.9	2.2	3.7	1.9	1.2	1.7	1.7	0.2
Impedance of whole body	1.9	9.7	24.1	-4.9	-1.3	-4.3	0.2	-2.0
Chronotype (morning person)	1.8	4.1	10.2	-0.1	-0.6	-2.8	-3.2	-1.4
Age when periods started (menarche)	1.8	4.3	13.2	-2.1	-3.6	-1.2	-1.1	-1.2
Impedance of arm (right)	1.8	8.6	23.4	-4.8	-1.1	-3.7	0.5	-2.1
Impedance of arm (left)	1.8	8.2	20.2	-4.5	-0.9	-4.1	0.3	-1.6
Medication: Lisinopril	1.8	2.3	4.6	-1.8	-1.5	-1.0	-0.7	-2.1
Crohns Disease (2012)	1.7	2.7	4.7	-1.0	-1.1	-2.1	-1.4	-2.2
Ulcerative Colitis	1.7	2.5	4.0	-1.7	-2.0	-1.7	-1.5	-0.7
Medication for hormone replacement therapy	1.7	1.9	4.2	1.8	0.2	0.8	-2.0	1.2
Number of live births	1.7	2.4	4.7	-1.5	-0.3	-1.8	-2.2	-1.5
Illnesses of siblings: Diabetes	1.7	2.1	6.6	-0.4	-0.2	-2.6	-1.9	-0.1
Pain type(s) experienced in last month: Hip pain	1.7	2.1	4.2	2.0	0.5	1.4	2.0	-0.3
Average weekly beer plus cider intake	1.7	2.5	8.2	0.4	1.2	0.1	-1.5	-2.9
Lung cancer (father)	1.6	1.8	5.5	1.7	-0.2	0.5	-0.6	2.4
Breastfed as a baby	1.6	1.9	3.2	-1.3	-1.8	-1.8	-1.3	0.4
Mean time to correctly identify matches	1.6	3.0	5.4	2.0	2.3	1.0	2.1	0.6
Supplements: Vitamin C	1.6	1.9	6.4	-1.0	-0.3	-1.4	0.2	-2.5
Basal metabolic rate	1.6	9.0	25.1	5.0	-0.1	2.7	-2.8	2.2
Arm fat-free mass (left)	1.6	8.2	22.0	4.7	-0.4	2.5	-2.9	2.0
Arm predicted mass (left)	1.6	8.0	22.7	4.8	-0.3	2.5	-2.8	1.8
Body Mass Index (BMI) (2010)	1.5	2.1	5.0	-1.3	-1.9	-0.3	0.3	2.2
Vitamin and mineral supplements	1.5	2.0	3.8	1.6	2.0	1.6	-0.1	0.9
Mouth/teeth dental problems: Dentures	1.5	2.4	5.6	1.7	2.4	1.3	1.0	1.0
Mouth/teeth dental problems: Loose teeth	1.5	1.8	2.8	-1.6	-1.3	-1.4	0.0	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.0	9.2	0.2	-2.4	-0.6	-3.0	-0.2
Impedance of leg (right)	1.4	6.6	16.0	-4.0	-1.3	-3.4	0.0	-1.9
Had major operations	1.4	1.6	4.0	1.8	0.3	2.0	-0.3	0.7
Leg fat-free mass (right)	1.4	7.6	20.7	4.5	-0.2	2.5	-2.5	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.4	4.3	0.8	-1.3	0.1	-0.8	2.1
Medication: Aspirin	1.4	1.8	4.0	-0.1	-1.3	-1.9	-2.0	-0.2
Leg predicted mass (right)	1.4	7.5	20.1	4.5	-0.2	2.5	-2.6	2.2
Ovarian Cancer	1.3	1.8	3.6	-1.2	-1.1	-1.9	-1.1	-1.2
Frequency of depressed mood in last 2 weeks	1.3	1.8	3.0	-1.6	-1.7	-1.4	0.0	-1.2
Leg fat-free mass (left)	1.3	7.0	18.7	4.3	-0.2	2.2	-2.9	1.7
Impedance of leg (left)	1.3	6.5	15.0	-3.9	-1.5	-3.5	-0.2	-1.7
Leg predicted mass (left)	1.3	6.7	18.0	4.2	-0.2	2.2	-2.8	1.7
Comparative height size at age 10	1.3	7.1	21.0	4.6	1.0	2.6	-1.1	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	6.0	0.1	1.3	0.2	2.4	-0.4
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.9	-0.7	-0.3	-0.0	2.0	-1.8
Medication: Blood pressure	1.3	2.4	4.3	-1.7	-0.9	-2.1	-1.2	-1.6
Risk taking	1.3	1.9	5.2	2.3	-0.3	1.2	1.0	1.3
Bipolar Disorder (2011)	1.2	1.1	3.4	0.4	-0.6	1.9	0.9	0.9
Diabetes (father)	1.2	1.5	5.4	-1.1	0.0	-0.7	-0.8	-2.3
Alcohol usually taken with meals	1.2	1.9	4.0	-0.7	-2.0	-1.4	-1.0	-1.4
Qualifications: nursing, teaching	1.2	1.9	3.8	-1.9	-1.6	-0.9	-1.3	-0.9
Irritable Bowel Disease (IBD)	1.1	2.6	3.2	-1.4	-1.8	-1.8	-1.2	-1.8
Type 2 Diabetes (T2D) (2018)	1.1	2.0	6.3	2.5	1.1	1.5	0.4	-0.1
Trunk fat percentage	1.1	4.3	10.1	-1.6	-1.7	-3.2	-2.3	-0.9
Nervous feelings	1.1	2.1	5.6	1.6	2.4	1.4	0.7	-0.1
Forced vital capacity (FVC)	1.1	4.1	8.8	2.7	1.3	3.0	-1.1	1.2
Hair/balding pattern: Pattern 3	1.1	1.7	4.0	-0.4	1.5	-0.4	1.3	2.0
Loud music exposure frequency	1.1	1.2	2.8	0.1	-1.5	-0.0	-0.9	1.7
Migraine (self-reported)	1.1	1.3	2.7	-1.5	-0.1	-0.9	1.0	-1.6
Medication: Aspirin	1.1	1.5	3.2	-0.1	-1.0	-1.8	-1.7	-0.6
Wears glasses or contact lenses	1.1	1.3	3.5	1.9	1.3	0.7	-0.3	0.8
Myopia	1.1	1.6	6.8	-0.1	-1.1	-0.1	-0.5	2.6
Cholesterol lowering medication	1.1	1.7	5.6	-1.0	-0.2	-1.3	0.2	-2.4
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.0	1.7	0.8	0.8	-0.5	1.7
Breast Cancer	1.0	2.3	6.3	0.6	2.5	1.0	2.0	0.0
Lung FVC	1.0	5.0	14.1	1.0	2.5	3.8	1.8	0.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.4	5.1	-0.8	-2.3	-0.3	-0.6	-0.7
Average weekly fortified wine intake	1.0	1.2	3.6	-0.2	-1.9	-0.2	-1.4	-0.5
Heart attack	1.0	1.3	3.1	1.8	0.7	0.8	-0.5	1.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	3.1	-0.9	-1.0	-1.8	-1.3	-0.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	9.6	2.1	0.6	3.1	-0.1	1.6
Forced vital capacity (FVC), Best measure	1.0	3.7	7.2	2.7	1.3	2.5	-1.4	1.1
Body fat percentage	1.0	3.8	8.7	-1.5	-1.5	-3.0	-2.1	-1.0
Number of full brothers	1.0	1.2	3.3	0.3	1.8	-0.8	-1.4	-0.4
Health satisfaction	1.0	1.2	4.3	-0.6	-1.2	-2.1	-0.3	-0.2
Commuting to job workplace: Walk	1.0	1.1	1.9	0.4	1.3	0.8	1.4	1.0
Basal cell carcinoma (self-reported)	1.0	1.2	2.7	-1.0	-0.4	-1.3	0.5	-1.6
Heart disease (siblings)	1.0	1.3	3.1	-0.7	-1.0	-1.8	-1.3	0.2
Alzheimer’s Disease (in father)	0.9	1.0	3.3	-0.5	-1.3	-0.0	0.1	1.8
Ulcerative Colitis (UC)	0.9	1.6	2.6	-1.2	-1.6	-1.3	-1.2	-1.0
Hearing difficulty/problems: Yes	0.9	1.4	5.3	-0.8	-0.4	-2.3	-0.8	-0.2
Diabetes (self-reported)	0.9	1.5	4.7	2.2	1.1	1.1	-0.2	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.3	-1.1	-0.7	-0.2	0.6	-1.8
Prospective memory result	0.9	1.1	1.6	0.9	1.2	-1.1	-0.3	-1.3
Exposure to tobacco smoke outside home	0.9	1.2	3.8	1.3	2.0	0.3	0.4	0.4
Comparative body size at age 10	0.9	2.5	4.1	1.8	0.6	1.3	-2.0	1.8
Emphysema/chronic bronchitis	0.9	1.0	2.7	1.6	0.8	1.1	0.4	0.5
Family relationship satisfaction	0.9	1.1	3.6	-0.6	0.4	-0.5	1.0	1.9
Average weekly red wine intake	0.9	1.4	3.6	1.2	0.5	1.3	0.1	1.9
Breast cancer (self-reported)	0.9	1.0	2.0	-1.4	-0.6	0.3	1.4	-0.9
Hearing aid user	0.9	1.0	3.2	0.7	0.8	0.7	1.8	-0.2
Financial situation satisfaction	0.9	1.1	2.7	-0.1	-1.1	0.2	1.6	1.2
Commuting to job workplace: Public transport	0.9	1.1	2.7	0.3	0.1	1.6	1.0	1.4
Crohns Disease (2017)	0.8	1.8	4.8	-0.8	-1.0	-1.3	-0.8	-2.2
Prostate Cancer	0.8	1.1	3.7	1.0	0.8	0.5	1.9	0.0
Cardiovascular Disease	0.8	2.6	6.3	-0.8	-1.2	-2.2	-2.5	-0.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.2	1.5	1.0	0.2	-0.9	1.0
Supplements: Zinc	0.8	0.9	1.6	0.8	1.3	0.3	0.7	1.1
Sitting height	0.8	5.8	15.8	4.0	0.3	3.3	-1.0	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	6.5	2.1	0.9	2.6	-0.2	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	2.0	-1.4	-1.3	-0.9	0.5	-1.3
Gout (self-reported)	0.8	1.1	2.7	0.2	0.1	1.6	1.7	0.3
Medication: Ventolin 100micrograms inhaler	0.8	1.0	4.0	-0.5	-0.3	-0.1	-0.9	-2.0
Worry too long after embarrassment	0.8	1.3	2.6	-1.4	-0.4	-1.2	1.6	-0.6
Eye problems/disorders: None of the above	0.8	0.9	1.9	-1.0	-0.1	-1.1	0.5	-1.4
Medication: Seretide 50 evohaler	0.8	0.9	2.1	-1.2	-1.4	-1.0	0.2	-0.4
Chest pain or discomfort	0.8	1.1	2.4	0.4	-1.6	-0.7	-1.5	-0.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.2	1.1	1.1	2.1	1.6	1.2
Alzheimer’s Disease (including proxy)	0.7	1.0	2.7	-0.5	-1.6	-0.1	1.1	1.0
Neuroticism (2016)	0.7	1.0	3.5	-0.6	-0.1	-0.7	0.8	-1.9
Triglycerides	0.7	1.1	2.4	0.5	0.1	1.3	1.0	1.5
Waist Hip Ratio (WHR)	0.7	3.0	4.9	-1.2	-0.7	-2.1	-2.2	-1.9
Medication: Metformin	0.7	1.1	3.6	1.9	1.1	0.0	-0.6	0.3
Maternal smoking around birth	0.7	1.1	3.0	1.7	0.2	1.4	0.5	0.2
High blood pressure	0.7	2.1	3.0	-0.9	-1.2	-1.7	-1.5	-1.7
Pain all over the body in last month	0.7	0.7	1.7	1.3	-0.4	0.0	-1.1	0.8
Weight	0.7	3.4	8.0	2.6	-0.9	0.5	-2.8	1.0
Qualifications: A levels/AS levels or equivalent	0.7	1.5	4.1	-1.2	-1.2	-0.5	0.3	2.0
Medication: Cholesterol lowering	0.7	1.1	4.4	2.1	0.6	0.7	-0.7	0.1
Headache pain in last month	0.7	1.2	2.6	-1.4	-0.6	-1.6	0.3	-0.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.6	-1.2	-0.5	-0.8	-1.3	0.5
Diabetes diagnosed by doctor	0.7	1.1	3.9	2.0	0.2	0.7	-0.4	-1.0
Age started oral contraceptive pill	0.7	0.9	1.7	-0.5	0.6	-0.8	1.2	1.3
Ever depressed for a whole week	0.7	0.9	2.1	1.3	0.3	0.8	1.4	-0.2
Depression (Nagel 2018)	0.6	0.9	2.0	-1.0	-0.8	-1.4	0.2	-0.9
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.2	0.9	1.3	1.8	1.5	1.3
Coronary Artery Disease (CAD)	0.6	0.8	2.5	-0.5	0.3	0.4	1.6	0.9
Fasting Glucose	0.6	0.7	1.9	0.1	0.0	1.4	1.1	-0.7
Lupus	0.6	1.0	2.7	0.6	-0.3	0.2	-1.3	-1.6
Primary Biliary Cirrhosis	0.6	0.9	2.7	1.0	0.7	1.6	0.3	-0.4
BMI	0.6	3.3	8.1	2.2	-0.6	0.3	-2.9	1.6
Number of treatments/medications taken	0.6	1.0	1.6	-0.3	-1.0	-1.1	-1.3	-1.1
Ever had hysterectomy (womb removed)	0.6	0.7	1.3	-0.1	0.5	-1.1	-0.8	1.0
Serious illness, injury or assault to yourself	0.6	0.7	1.3	0.7	-0.9	0.5	1.2	-0.7
Stomach or abdominal pain in last month	0.6	0.8	2.6	1.6	0.8	0.4	0.4	0.4
Chronic bronchitis/emphysema (father)	0.6	0.7	3.0	-0.7	-0.2	-0.1	1.7	-0.1
Trunk fat mass	0.6	2.6	7.4	0.2	-1.5	-1.9	-2.7	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.5	0.1	0.1	0.4	1.9	-0.9
Allergy	0.6	1.3	2.3	0.7	1.3	1.5	1.1	1.0
Standing height	0.6	5.8	13.1	3.6	-1.2	1.1	-2.9	2.3
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	2.7	-0.4	-1.6	0.1	0.8	1.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.2	-1.8	-0.6	-0.2	1.2	0.2
Glaucoma (self-reported)	0.6	0.7	1.1	1.0	0.5	0.6	-1.0	0.8
Birth weight	0.6	1.4	3.3	1.8	1.2	0.7	-0.5	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	3.0	0.4	-0.3	0.5	-0.4	1.7
Age at first live birth	0.6	1.0	2.9	-0.3	1.1	1.0	1.7	-0.1
Medication: Omeprazole	0.6	0.8	2.1	-0.5	-0.6	-1.5	-0.7	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.5	-1.2	0.0	-0.6	0.8	-1.1
Leg pain on walking	0.6	0.7	1.6	1.2	-0.3	0.3	0.4	1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	-1.1	-0.7	-1.0	-0.4	0.7
Osteoarthritis (self-reported)	0.6	0.8	2.7	1.6	0.9	0.7	0.2	0.4
Medication: Gliclazide	0.6	0.7	2.4	1.5	1.1	0.1	0.1	-0.2
Medication: Atorvastatin	0.6	0.7	1.7	0.4	-1.3	0.1	-1.2	-0.1
Age at First Birth	0.5	0.8	1.6	1.1	1.3	0.8	0.7	-0.1
Respiratory disease	0.5	1.0	2.9	0.0	-0.8	-1.0	-1.7	-0.9
Lung FEV1/FVC ratio	0.5	2.4	6.7	-0.2	-1.5	1.5	2.6	1.0
Average weekly spirits intake	0.5	0.7	2.8	-0.3	-1.7	0.2	0.2	0.6
Severe depression (siblings)	0.5	0.5	2.0	0.7	-0.2	-0.3	-1.4	0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	1.1	0.2	-0.3	-1.4	-0.0
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.8	-0.6	-1.3	-1.2	-1.3	-0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	0.4	1.1	0.3	1.1	-0.4
Medication: Levothyroxine sodium	0.5	0.9	1.8	-0.8	-0.6	-1.3	-1.1	-0.7
Number of incorrect matches in round	0.5	0.9	2.0	-0.1	1.3	-1.0	-0.2	-1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.2	0.3	-0.4	0.7	1.5	0.1
Mouth/teeth dental problems	0.5	0.7	1.8	-0.4	-1.0	-0.7	-1.3	-0.5
Fluid intelligence score	0.5	1.1	2.6	0.8	0.9	1.6	1.1	0.2
Arm fat percentage (right)	0.5	1.8	3.9	-1.1	-0.8	-2.0	-1.7	-0.7
Hip circumference	0.5	2.2	6.0	2.5	-0.6	0.6	-2.0	0.7
Depression (self-reported)	0.5	0.5	0.9	-0.9	-0.9	-0.3	-0.3	-0.9
Medication: Lansoprazole	0.5	0.6	1.6	0.3	-1.3	0.2	-1.0	-0.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	0.6	0.4	0.3	1.0	1.2
Birth weight of first child	0.5	0.9	3.5	-0.0	-0.2	-0.7	-1.9	-0.6
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.3	0.8	-1.1	-0.6	-0.9	-0.0
High blood pressure (siblings)	0.5	0.7	1.7	-1.2	0.2	-0.2	1.3	-0.6
Pulse wave peak to peak time	0.5	0.6	1.6	-0.3	-0.4	-0.2	-1.3	-0.9
Shortness of breath walking on level ground	0.5	0.6	1.7	0.6	-0.6	-0.6	-0.5	-1.3
Heart disease (mother)	0.5	0.6	1.2	-0.2	-0.9	-1.1	0.4	1.0
Whole body fat mass	0.5	2.1	6.6	0.4	-1.3	-1.4	-2.6	-0.1
Hypertension (Self-reported)	0.5	1.4	2.1	-0.7	-0.8	-1.4	-1.4	-1.4
Arm fat percentage (left)	0.5	2.0	4.7	-0.9	-0.8	-2.2	-1.9	-0.5
Eye problems/disorders: Cataract	0.5	0.6	1.0	-0.7	-0.4	-1.0	-0.6	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.7	0.7	-0.7	0.5	-0.5	1.6
Back pain experienced in last month	0.5	0.8	1.9	1.3	0.2	0.5	-0.2	1.4
Miserableness	0.5	0.8	1.5	-0.4	-1.2	-0.4	-0.8	-1.2
Ever taken oral contraceptive pill	0.5	0.6	1.7	-0.8	-0.3	-0.6	-0.4	-1.3
Leg fat percentage (left)	0.5	1.7	3.5	-0.5	-1.0	-1.9	-1.8	-0.5
Diastolic blood pressure, automated reading	0.5	1.4	2.1	-1.4	-1.4	-1.2	-0.7	-1.2
Pain experienced in last month	0.5	0.8	2.6	-1.6	-0.8	-0.3	-0.3	-0.7
Leg fat mass (left)	0.5	1.8	6.3	0.9	-1.0	-0.9	-2.5	0.1
Schizophrenia (2018)	0.4	0.8	2.5	-1.6	-0.5	-0.6	-0.2	-1.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.7	0.7	0.5	-0.1	-0.0	-1.3
Major Depression (MDD)	0.4	0.5	1.0	-0.6	-0.8	-1.0	-0.1	-0.5
Heel T-Score	0.4	3.1	5.4	1.2	2.0	1.0	2.3	1.9
Height	0.4	8.7	27.9	5.3	-0.3	2.3	-2.7	1.7
Systolic Blood Pressure	0.4	1.8	2.7	-1.6	0.9	-1.6	-0.6	-1.7
Diabetes (mother)	0.4	0.5	1.4	0.5	-0.3	1.2	0.4	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.3	1.3	1.5	0.6	0.3	0.1
Multivitamins +/- minerals	0.4	0.5	1.3	-0.4	-0.7	-0.7	-0.1	-1.1
Waist circumference	0.4	1.6	5.9	0.9	-0.8	-0.7	-2.4	0.1
Father’s age at death	0.4	0.6	1.6	-1.0	-1.3	-0.2	0.4	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.0	0.4	0.8	0.6	0.6	-1.4
Pulse rate	0.4	0.6	1.5	-0.4	1.2	-0.1	1.2	-0.2
Exposure to tobacco smoke at home	0.4	0.5	2.1	1.4	0.3	0.3	-0.2	0.1
Tense / ‘highly strung’	0.4	0.7	2.3	-0.5	0.1	-0.1	1.5	-1.0
Hair/balding pattern: Pattern 4	0.4	0.9	1.8	0.7	0.4	1.3	1.1	-0.8
Medication: Amlodipine	0.4	0.6	1.4	0.7	0.9	0.3	-1.2	-0.1
Leg fat percentage (right)	0.4	1.6	3.5	-0.7	-0.9	-1.9	-1.5	-0.8
Wheeze or whistling in the chest in last year	0.4	0.8	1.8	-0.0	-0.5	-1.3	-0.7	-1.2
Number of children fathered	0.4	0.4	1.4	0.3	0.2	-0.3	-0.7	-1.2
Leg fat mass (right)	0.4	1.4	5.0	0.8	-0.9	-0.8	-2.2	-0.0
Loneliness, isolation	0.4	0.5	1.2	0.4	0.3	-0.3	1.1	-1.1
Long-standing illness, disability or infirmity	0.4	0.7	2.4	1.5	-0.1	0.4	-0.5	-0.7
Ever had bowel cancer screening	0.4	0.4	1.4	-0.1	-1.2	-0.3	0.3	0.7
Friendships satisfaction	0.4	0.6	2.2	-0.2	-0.1	-1.5	-0.6	0.4
Asthma (self-reported)	0.4	0.8	2.0	-0.5	-0.4	-1.0	-0.7	-1.4
Arm fat mass (left)	0.4	1.7	6.0	0.9	-0.9	-0.9	-2.4	0.4
Medication: Bendroflumethiazide	0.4	0.6	1.3	0.7	0.2	-0.9	-0.4	-1.1
Alcohol drinker status: Never	0.4	0.5	2.1	0.4	0.4	1.5	0.0	-0.3
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	0.8	0.1	0.4	0.7	1.0
Fractured/broken bones in last 5 years	0.4	0.5	1.6	0.0	0.2	0.9	1.2	0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.1	-0.3	-0.6	-1.1	-0.6	-0.5
Supplements: Calcium	0.4	0.4	0.8	-0.8	-0.6	-0.9	0.2	-0.6
Bipolar Disorder (2018)	0.3	0.4	0.9	1.0	0.2	-0.1	-0.9	0.6
Worry (Nagel 2018)	0.3	0.7	1.5	0.7	0.7	1.2	0.7	0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.8	0.5	0.4	1.4	1.0	0.3
HbA1C	0.3	0.3	1.1	-0.1	-0.3	0.5	0.1	1.1
Allergy or Eczema	0.3	0.7	2.0	-0.7	-1.4	-0.7	-0.7	0.3
Hand grip strength (left)	0.3	0.8	1.7	0.4	-1.3	1.1	0.1	-0.8
Sensitivity / hurt feelings	0.3	0.5	0.8	0.3	0.9	0.8	0.7	-0.7
Angina	0.3	0.3	1.2	0.2	-0.3	-1.1	-0.6	-0.1
Medication: Co-codamol	0.3	0.4	1.6	0.2	-0.2	1.2	0.3	0.5
Pack years adult smoking proportion	0.3	0.4	0.8	0.4	-0.7	-0.3	-0.9	-0.6
Hand grip strength (right)	0.3	0.7	2.2	1.0	0.0	1.5	0.7	-0.0
Fed-up feelings	0.3	0.5	1.5	0.7	-0.2	-0.2	0.8	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.6	0.8	-0.7	0.5	-0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	0.4	-0.9	0.5	0.2	0.4
Supplements: Glucosamine	0.3	0.4	0.7	0.9	-0.4	-0.4	-0.8	0.5
Hearing difficulty/problems with background noise	0.3	0.5	1.6	0.2	-0.1	-1.2	-1.1	-0.1
Had menopause	0.3	0.4	1.5	-0.1	0.3	-1.2	0.5	-0.2
Illnesses of siblings	0.3	0.4	1.4	0.5	0.3	1.2	0.3	0.0
Alcohol intake versus 10 years previously	0.3	0.5	1.6	0.9	-0.1	-0.3	0.0	-1.2
Falls in the last year	0.3	0.5	1.5	-0.3	-1.2	0.0	0.6	-0.6
Noisy workplace	0.3	0.3	1.3	1.1	-0.0	0.4	-0.2	-0.5
Asthma	0.3	0.6	1.2	-0.4	-0.6	-0.9	-0.8	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	0.9	0.2	0.3	0.5	1.0	0.7
Arm fat mass (right)	0.3	1.3	5.1	0.7	-0.8	-0.7	-2.3	0.2
Peak expiratory flow (PEF)	0.3	0.7	2.5	-0.3	-1.6	0.6	0.7	0.4
Blood clot in the leg (DVT)	0.3	0.4	1.3	0.4	-0.0	1.2	0.6	0.1
Medication: Blood pressure	0.3	0.5	2.0	0.6	-0.1	-0.2	-1.4	-0.4
Knee pain experienced in last month	0.3	0.5	2.3	1.5	0.2	0.2	0.2	-0.4
Mood swings	0.3	0.5	1.6	-0.1	-0.5	-0.6	-0.2	-1.3
Guilty feelings	0.3	0.4	1.0	0.4	-1.0	-0.8	-0.5	-0.0
Mother’s age at death	0.3	0.4	1.1	-1.1	-0.8	-0.0	-0.1	0.3
Medication: Paracetamol	0.3	0.5	1.5	0.3	-0.6	-0.6	-1.2	0.0
Number of operations (self-reported)	0.3	0.4	0.9	0.5	-1.0	0.7	-0.4	-0.6
Unable to work because of sickness or disability	0.3	0.4	1.2	0.8	0.1	-0.1	0.4	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.2	0.3	0.1	1.1	0.6	0.0
Pack years of smoking	0.3	0.5	0.7	0.4	-0.8	-0.7	-0.8	-0.7
Neuroticism (Nagel 2018)	0.2	0.5	1.7	0.5	0.0	0.8	1.3	0.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	0.6	-0.8	0.2	0.2	0.3
HDL Cholesterol	0.2	0.3	0.9	-0.3	0.4	-0.3	0.8	-0.9
Rheumatoid Arthritis	0.2	0.3	1.2	0.5	-0.0	-0.3	-0.0	1.1
Schizophrenia (2014)	0.2	0.4	0.8	-0.8	-0.9	-0.6	-0.1	-0.5
Systolic blood pressure, automated reading	0.2	0.6	1.7	-0.9	0.0	-0.7	-0.5	-1.3
Townsend deprivation index at recruitment	0.2	0.3	1.1	-0.1	-0.6	0.2	-0.1	1.0
Current tobacco smoking	0.2	0.3	0.6	-0.8	-0.7	-0.5	0.4	0.2
Qualifications: CSEs or equivalent	0.2	0.2	0.7	-0.0	-0.5	-0.8	-0.4	-0.1
High blood pressure (mother)	0.2	0.3	1.2	-0.1	-0.0	0.4	-0.2	1.1
Body mass index (BMI)	0.2	0.9	3.3	1.1	-0.3	-0.0	-1.8	0.1
Hair/balding pattern: Pattern 2	0.2	0.3	1.0	-0.2	0.1	-0.7	1.0	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.7	0.5	1.3	0.4	-0.1	-0.5
Qualifications: None of the above	0.2	0.4	1.3	1.1	0.0	0.0	-0.3	-0.8
Medication: Ramipril	0.2	0.3	1.1	1.0	0.1	0.0	-0.1	0.5
Medication: Simvastatin	0.2	0.3	1.4	0.2	0.5	-0.0	-0.3	-1.2
Neuroticism score	0.2	0.4	0.8	-0.2	-0.6	-0.8	-0.1	-0.9
Happiness	0.2	0.2	0.3	-0.5	-0.5	0.0	0.6	0.4
Illnesses of mother	0.2	0.3	0.4	0.5	0.6	0.6	-0.6	0.1
Length of working week for main job	0.2	0.2	0.5	0.0	0.7	0.2	-0.6	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.7	0.8	0.5	-0.6	-0.1	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.3	-0.3	0.2	0.2	1.1	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.1	0.8	1.0	-0.2	-0.1
Angina (self-reported)	0.2	0.2	1.0	0.3	-0.1	-1.0	-0.4	-0.2
Medication: Allopurinol	0.2	0.3	0.7	-0.0	-0.2	0.9	0.6	-0.5
Pulse rate, automated reading	0.2	0.6	0.9	-0.4	1.0	0.9	0.9	-0.6
Overall health rating	0.2	0.5	1.1	1.0	-0.6	-0.3	-0.9	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.4	-0.4	-0.0	-0.4	-0.6	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.6	-0.7	-0.0	-0.8	-0.1	0.3
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	0.6	0.5	0.2	-0.6	0.7
High cholesterol (Self-reported)	0.2	0.4	1.4	-0.2	0.4	-1.2	-0.2	-0.6
Irritability	0.2	0.3	1.0	-0.2	-1.0	-0.2	0.5	-0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.6	-0.3	-0.5	-0.8	-0.1
LDL Cholesterol	0.1	0.1	0.4	0.1	-0.6	0.2	-0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.4	0.6	0.0	0.0	-0.6	-0.2
Blood Platelet Count	0.1	1.3	3.8	-1.0	-0.4	0.4	1.0	-1.9
Blood Red Count	0.1	1.1	2.2	-0.2	1.2	0.7	1.5	1.0
Blood White Count	0.1	0.7	1.6	-0.2	0.1	-0.6	-1.2	-1.3
Hypothyroidism (self reported)	0.1	0.2	0.4	0.4	0.6	-0.4	-0.5	0.0
Neuroticism	0.1	0.3	0.6	-0.4	-0.8	-0.1	0.5	-0.6
Financial difficulties in last 2 years	0.1	0.1	0.4	-0.2	0.1	-0.1	0.2	0.6
Worrier / anxious feelings	0.1	0.2	0.4	0.3	0.7	0.6	0.2	-0.3
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.5	-0.7	0.0	0.0	0.5	-0.2
Medication: Paracetamol	0.1	0.2	0.6	0.3	-0.8	0.1	-0.6	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.5	0.3	0.5	-0.5	-0.7	-0.1
Medication: Ibuprofen	0.1	0.2	0.5	0.2	0.3	0.3	0.3	0.7
Alcohol intake frequency.	0.1	0.2	0.7	0.0	0.8	-0.2	0.0	0.4
Number of full sisters	0.1	0.1	0.2	-0.4	-0.3	-0.1	-0.4	-0.5
Suffer from ‘nerves’	0.1	0.2	0.5	0.4	0.7	0.2	0.2	-0.2
Age at last live birth	0.1	0.2	0.3	-0.1	-0.1	0.5	0.4	-0.5
Mineral and other dietary supplements	0.1	0.1	0.4	-0.2	0.4	0.2	0.1	0.6
Smoking status: Current	0.1	0.2	0.4	-0.6	-0.6	-0.6	-0.0	-0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.4	0.2	-0.7	0.6	-0.0	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.6	0.8	0.4	-0.0	0.0	0.2
Alcohol drinker status: Previous	0.1	0.1	0.4	0.1	-0.1	-0.6	-0.4	0.4
Depressed Affect (Nagel 2018)	0.0	0.1	0.2	0.4	-0.2	0.4	0.4	-0.0
Hair Pigment	0.0	0.4	1.6	0.2	-1.3	-0.1	0.5	0.4
Tanning	0.0	0.3	0.7	0.1	-0.8	0.6	0.5	0.2
Qualifications: College or University degree	0.0	0.2	0.3	-0.6	0.4	-0.4	-0.2	0.3

Hub : Genes

C20orf26

Models

Trait associations