TWAS hub - CRNKL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hippocampus	0.325	0.1205	0.0087	-0.007	NA	0.006	NA	0.009	5.2e-01	NA	2.3e-01	NA	1.9e-01
2	YFS	Blood	0.211	0.0243	0.0000	0.252	0.174	0.272	0.173	0.142	8.9e-82	1.8e-54	2.4e-89	2.5e-54	5.6e-44
3	TCGA	Pheochromocytoma and Paraganglioma	0.215	0.0940	0.0033	0.023	0.037	0.059	NA	0.043	4.2e-02	1.3e-02	2.2e-03	NA	8.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pain experienced in last month	5.6	9.3	22.4	0.7	2.2	4.7
Time employed in main current job	4.7	5.4	8.4	-2.9	-2.2	-1.7
Illnesses of father: None of the above (group 1)	4.7	5.8	9.5	0.8	-3.1	-2.7
Back pain experienced in last month	3.8	5.5	13.3	-0.7	-1.7	-3.6
Knee pain experienced in last month	3.5	5.4	14.2	0.1	-1.4	-3.8
Illnesses of father: Heart disease	3.4	4.7	8.1	-0.4	2.4	2.8
Noisy workplace	3.3	4.0	7.2	1.9	-1.1	-2.7
Handedness (chirality/laterality): Left-handed	3.1	3.8	10.3	0.4	3.2	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	2.9	3.1	5.7	2.4	-0.8	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	6.2	-1.9	-0.8	-2.5
Trunk predicted mass	2.7	15.2	37.9	-1.4	-6.2	-2.4
Trunk fat-free mass	2.6	15.2	38.2	-1.4	-6.2	-2.3
Medication: Gliclazide	2.6	3.0	6.4	2.5	-1.0	-1.2
Heart attack	2.5	3.2	6.8	1.3	-2.6	-1.1
Overall health rating	2.5	5.5	14.2	-0.7	-1.3	-3.8
Heart attack/myocardial infarction (self-reported)	2.5	3.2	6.7	1.4	-2.6	-1.1
Pain type(s) experienced in last month: Hip pain	2.4	3.0	4.4	-0.9	-2.0	-2.1
Type 2 Diabetes (T2D) (2012)	2.3	2.6	4.7	-1.3	-1.2	-2.2
Diabetes (self-reported)	2.2	3.4	5.4	1.4	-1.7	-2.3
Arm fat-free mass (right)	2.2	11.1	26.6	-1.7	-5.2	-2.0
Arm predicted mass (right)	2.2	11.1	26.8	-1.6	-5.2	-2.0
Medication: Metformin	2.1	2.9	4.2	2.1	-1.3	-1.7
Supplements: Glucosamine	2.1	2.7	6.6	-0.8	-0.9	-2.6
Nervous feelings	2.1	3.9	5.5	-1.9	-1.6	-2.3
Health satisfaction	2.1	2.7	8.0	-0.2	0.4	-2.8
Diabetes diagnosed by doctor	2.1	3.4	7.2	0.9	-1.5	-2.7
Had other major operations	2.0	2.5	3.9	0.5	1.8	2.0
Comparative height size at age 10	2.0	10.9	24.3	-0.3	-4.9	-2.9
Illnesses of siblings: Diabetes	2.0	2.5	6.8	-0.8	0.3	-2.6
Whole body fat-free mass	2.0	11.2	28.7	-1.1	-5.4	-2.0
Qualifications: nursing, teaching	2.0	3.1	4.9	0.5	2.2	2.1
Unable to work because of sickness or disability	2.0	2.6	5.1	1.5	-0.6	-2.3
Illnesses of siblings	1.9	2.6	6.8	1.0	-0.0	2.6
Number of live births	1.9	2.7	6.3	2.5	1.3	0.3
Whole body water mass	1.9	11.0	27.9	-1.1	-5.3	-2.0
Arm fat-free mass (left)	1.9	9.4	21.1	-1.6	-4.6	-2.1
Ever depressed for a whole week	1.9	2.4	5.0	2.2	-1.0	-1.0
Arm predicted mass (left)	1.9	9.5	20.9	-1.8	-4.6	-2.1
Serious illness, injury or assault to yourself	1.8	2.2	4.3	-1.4	-0.5	-2.1
Ever had prostate specific antigen (PSA) test	1.8	2.1	2.8	-1.7	-0.9	-1.6
Stomach or abdominal pain in last month	1.7	2.1	3.7	0.4	-1.6	-1.9
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	3.3	-1.2	1.4	1.8
Impedance of arm (right)	1.7	7.7	20.7	1.4	4.6	0.7
Ever smoked	1.7	2.9	3.6	1.3	1.8	-1.9
Basal metabolic rate	1.7	9.4	23.6	-1.0	-4.9	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	4.9	1.2	0.3	-2.2
Medication: Atenolol	1.6	2.0	5.7	0.1	2.4	0.4
Pain all over the body in last month	1.6	1.8	3.0	1.7	-1.3	-0.8
Prospective memory result	1.6	1.9	4.8	0.2	-1.0	-2.2
Medication: Omeprazole	1.6	2.0	4.4	1.2	0.0	-2.1
Number of full sisters	1.6	1.9	5.5	0.3	0.4	-2.3
Commuting to job workplace: Walk	1.6	1.7	2.4	1.6	-0.7	-1.5
Supplements: Zinc	1.5	1.6	1.7	1.3	-1.2	-1.3
Impedance of arm (left)	1.5	6.7	17.4	1.4	4.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.2	-1.8	1.4	0.4
Had major operations	1.5	1.8	4.3	-0.2	-2.1	-1.0
Leg pain on walking	1.5	1.9	3.9	0.2	-1.3	-2.0
Ever taken oral contraceptive pill	1.5	1.7	3.4	0.6	1.2	1.8
Father’s age at death	1.4	1.9	2.5	-1.6	0.7	1.6
Pulse rate	1.4	2.3	6.0	1.0	0.2	-2.4
Supplements: Vitamin C	1.4	1.6	2.7	1.6	1.1	1.0
Medication: Aspirin	1.4	1.8	4.3	-1.0	-0.5	-2.1
Type 2 Diabetes (T2D) (2018)	1.3	2.4	3.6	0.8	-1.7	-1.9
Average weekly spirits intake	1.3	1.6	4.2	0.5	0.4	2.1
Relative age voice broke	1.3	2.0	5.7	0.4	2.4	-0.5
Alcohol usually taken with meals	1.3	2.0	4.3	-2.1	1.3	0.2
Medication: Ramipril	1.3	1.6	4.2	0.0	-0.9	-2.0
Alcohol intake versus 10 years previously	1.3	1.9	3.0	0.8	-1.4	-1.7
Depression (self-reported)	1.3	1.6	2.0	-1.3	1.0	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.6	2.9	-1.2	-0.6	1.7
Medication: Aspirin	1.3	1.7	4.3	-0.8	-0.3	-2.1
Osteoarthritis (self-reported)	1.3	1.6	3.1	-0.6	-1.2	-1.8
Wears glasses or contact lenses	1.3	1.5	3.0	-1.1	-1.7	-0.6
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.1	1.2	-0.8	-1.8
Illnesses of father: High blood pressure	1.3	1.7	4.7	-0.5	2.2	0.1
Basal cell carcinoma (self-reported)	1.3	1.5	2.0	-0.9	1.4	-1.3
Impedance of whole body	1.3	6.8	19.9	0.1	4.5	0.7
Relative age of first facial hair	1.2	2.5	6.7	0.8	2.6	0.3
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	3.5	1.9	-0.1	-1.0
Mouth/teeth dental problems	1.2	1.9	5.3	-2.3	0.5	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	4.1	-0.4	1.1	-2.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.4	1.2	1.5	0.7
Emphysema/chronic bronchitis	1.2	1.4	2.8	1.1	-1.7	-0.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.5	0.6	0.7	1.9
Leg fat-free mass (right)	1.2	6.3	17.6	-0.3	-4.2	-1.2
Cholesterol lowering medication	1.2	1.8	2.9	-1.7	1.0	-1.2
Reaction Time	1.1	2.1	5.0	0.4	-2.2	-1.0
Frequency of depressed mood in last 2 weeks	1.1	1.6	2.5	-1.2	1.6	0.9
Vitamin and mineral supplements	1.1	1.5	3.0	-1.1	-1.7	-0.4
Leg fat-free mass (left)	1.1	5.9	15.9	-0.3	-4.0	-1.3
Average weekly fortified wine intake	1.1	1.2	3.4	0.2	0.5	1.8
Maternal smoking around birth	1.1	1.5	3.3	0.0	-1.8	-1.1
Sitting height	1.1	7.7	15.8	-1.6	-4.0	-2.2
Leg predicted mass (left)	1.1	5.6	15.2	-0.2	-3.9	-1.3
Medication: Simvastatin	1.1	1.5	4.2	-2.0	-0.2	-0.6
Loud music exposure frequency	1.1	1.2	3.2	1.8	-0.2	-0.6
High blood pressure (siblings)	1.1	1.5	2.1	-1.3	0.9	-1.4
Migraine (self-reported)	1.1	1.4	3.6	-0.8	1.9	0.4
Commuting to job workplace: Car/motor vehicle	1.1	1.3	2.4	-0.2	1.6	1.2
Smoking status: Previous	1.1	1.6	3.3	-1.1	1.8	-0.5
Leg predicted mass (right)	1.1	6.1	17.0	-0.3	-4.1	-1.1
Risk taking	1.1	1.6	3.2	1.2	-1.8	-0.0
Supplements: Calcium	1.1	1.2	1.8	-1.3	0.9	1.0
Lupus	1.0	1.5	3.2	-1.8	-1.0	-0.5
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.1	-0.0	-1.8	-0.3
Medication: Levothyroxine sodium	1.0	1.6	3.5	1.9	1.2	0.3
Past tobacco smoking	1.0	1.8	4.5	0.1	-2.1	0.9
Lung cancer (father)	1.0	1.2	2.7	-1.0	-1.6	-0.1
Pulse wave Arterial Stiffness index	1.0	1.1	1.2	-1.0	-1.1	-1.1
Exposure to tobacco smoke at home	1.0	1.1	2.0	-1.2	-1.4	0.2
Pulse wave reflection index	1.0	1.2	2.0	-1.0	-1.4	0.8
Forced vital capacity (FVC), Best measure	1.0	3.5	9.5	0.3	-3.1	-0.9
Neck or shoulder pain in last month	1.0	1.4	2.7	-1.2	0.3	-1.7
Angina (self-reported)	1.0	1.3	2.8	-1.0	-0.5	-1.7
Long-standing illness, disability or infirmity	1.0	1.6	3.4	0.3	-1.1	-1.8
Ever had bowel cancer screening	1.0	1.1	3.2	-0.4	-0.2	-1.8
High cholesterol (Self-reported)	1.0	1.8	3.5	-1.9	0.1	-1.4
Medication: Lisinopril	1.0	1.3	3.4	-0.7	1.8	-0.2
Commuting to job workplace: Cycle	1.0	1.2	2.3	-1.5	-1.1	-0.2
Major Depression (MDD)	0.9	1.1	2.2	-0.3	1.0	-1.5
Crohns Disease (2012)	0.9	1.4	3.1	1.8	0.9	0.6
Blood Eosinophil Count	0.9	6.7	20.0	-0.4	4.5	0.2
Medication for hormone replacement therapy	0.9	1.0	2.6	0.1	-1.6	0.6
Severe depression (siblings)	0.9	1.0	2.3	1.5	-0.9	-0.2
Fed-up feelings	0.9	1.7	3.7	-0.6	-1.0	-1.9
Age when periods started (menarche)	0.9	2.2	5.3	-0.6	2.3	0.9
Hearing difficulty/problems with background noise	0.9	1.4	2.2	1.5	0.3	1.3
Forced vital capacity (FVC)	0.9	3.4	9.0	-0.0	-3.0	-1.0
Qualifications: None of the above	0.9	2.0	4.2	0.6	-1.2	-2.0
Worrier / anxious feelings	0.9	1.7	2.5	-1.6	-0.4	-1.6
Medication: Cholesterol lowering	0.9	1.4	3.1	-0.1	-1.8	-1.1
Illnesses of mother	0.9	1.1	2.6	-1.6	-0.8	-0.2
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	4.2	0.4	0.2	2.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.4	-0.3	1.4	1.6
Number of full brothers	0.9	1.1	3.2	1.8	-0.4	0.3
Mean time to correctly identify matches	0.9	1.7	2.9	0.3	-1.5	-1.7
Average weekly champagne plus white wine intake	0.9	1.3	2.2	1.5	0.5	1.2
Depression (Nagel 2018)	0.8	1.2	1.9	0.8	1.0	1.4
Schizophrenia vs Biploar Disorder	0.8	1.0	2.5	-0.6	-0.5	-1.6
Alzheimer’s Disease (in mother)	0.8	0.9	1.4	-1.1	-0.3	-1.2
Height	0.8	16.3	29.8	-0.3	-5.5	-4.4
Angina	0.8	1.1	2.9	-0.5	-0.4	-1.7
Medication: Co-codamol	0.8	0.9	1.7	-1.3	-0.6	-0.9
Diabetes (father)	0.8	1.0	2.3	0.8	1.5	0.4
Impedance of leg (right)	0.8	3.9	11.1	-0.6	3.3	0.4
Townsend deprivation index at recruitment	0.8	1.1	2.9	1.7	-0.1	-0.6
Impedance of leg (left)	0.8	4.1	10.8	-1.1	3.3	0.4
Mouth/teeth dental problems: Dentures	0.8	1.4	3.3	0.6	-1.8	-0.8
Standing height	0.8	7.6	15.2	-1.2	-3.9	-2.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.4	1.6	0.8	-0.1
Exposure to tobacco smoke outside home	0.8	1.1	2.0	0.5	-1.4	-1.0
Comparative body size at age 10	0.8	2.2	4.7	-1.2	-2.2	0.7
Pulse wave peak to peak time	0.8	0.9	1.1	1.0	0.8	1.0
Shortness of breath walking on level ground	0.8	1.0	2.3	0.6	-0.6	-1.5
Medication: Seretide 50 evohaler	0.8	0.9	1.9	-1.4	0.9	-0.1
Chest pain or discomfort	0.8	1.2	1.7	-1.3	-0.6	-1.2
Age at last live birth	0.8	1.2	2.4	0.8	0.7	1.5
Friendships satisfaction	0.8	1.0	1.6	-1.2	0.1	-1.2
Mineral and other dietary supplements	0.8	1.0	2.7	-0.6	0.1	1.7
Alzheimer’s Disease (including proxy)	0.7	1.0	2.5	-1.6	0.8	0.2
Prostate Cancer	0.7	1.0	2.0	-1.4	-1.0	-0.2
Fasting Glucose	0.7	0.9	2.3	1.5	0.4	0.5
Hearing difficulty/problems: Yes	0.7	1.1	1.6	1.3	1.0	-0.9
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.6	-0.5	-1.3	-0.9
Current tobacco smoking	0.7	1.2	2.3	1.1	0.3	-1.5
Taking other prescription medications	0.7	1.0	3.0	-0.1	1.7	-0.0
Hip circumference	0.7	3.0	5.2	-1.2	-2.3	-1.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	5.8	0.2	-2.4	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.4	6.3	0.2	-2.5	-0.8
Breastfed as a baby	0.7	0.9	2.4	-0.1	1.5	0.6
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.2	0.5	-0.5	-1.5
Alcohol intake frequency.	0.7	1.6	3.1	1.2	-0.4	-1.8
Suffer from ‘nerves’	0.7	1.1	2.2	-1.5	-0.3	-1.0
Family relationship satisfaction	0.7	0.9	2.3	1.5	0.4	-0.4
Medication for cholesterol	0.7	1.0	1.7	1.3	-0.1	1.2
Breast cancer (self-reported)	0.7	0.8	1.2	0.3	1.1	1.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.9	0.7	1.4	0.3
Age started oral contraceptive pill	0.7	0.9	1.8	-1.4	0.8	-0.6
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.8	0.8	-0.7	2.2
Alcohol drinker status: Previous	0.7	0.8	1.2	1.1	-0.4	-1.0
Worry (Nagel 2018)	0.6	1.2	2.0	-1.0	-0.8	-1.4
Mean Putamen Volume	0.6	0.7	1.6	-0.4	0.6	1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.5	0.3	1.2	-0.7
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.8	-0.4	-0.2	1.3
Fluid intelligence score	0.6	1.2	3.0	0.5	-0.6	1.7
Weight	0.6	2.8	5.8	-0.8	-2.4	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.4	-1.0	-0.6	-1.2
Falls in the last year	0.6	0.8	1.7	0.6	0.6	-1.3
Tense / ‘highly strung’	0.6	1.0	1.6	-1.3	0.2	-1.1
Headache pain in last month	0.6	1.0	1.9	0.4	1.4	-0.9
Birth weight	0.6	1.3	3.1	0.7	-1.8	-0.6
Average weekly red wine intake	0.6	0.9	1.5	-1.2	-1.1	-0.1
Smoking status: Current	0.6	0.9	1.5	1.1	0.3	-1.2
Number of self-reported non-cancer illnesses	0.6	1.0	1.8	-0.7	0.7	-1.3
Mother’s age at death	0.6	0.8	1.4	-0.8	1.2	0.5
Ovarian Cancer	0.5	0.6	1.0	-1.0	0.9	0.3
Body Mass Index (BMI) (2010)	0.5	0.7	1.1	0.0	1.0	1.0
Rheumatoid Arthritis	0.5	0.7	1.2	1.1	-0.4	0.8
Ulcerative Colitis	0.5	0.8	1.5	0.0	1.2	0.9
Pack years adult smoking proportion	0.5	0.8	2.2	0.3	-0.4	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.0	1.0	-0.9	-0.1
High blood pressure	0.5	1.4	2.6	-0.9	0.8	-1.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.4	-0.6	0.2	-1.2
Hair/balding pattern: Pattern 2	0.5	0.7	1.4	-0.7	-0.3	-1.2
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.1	-0.7	0.8	1.5
Asthma	0.5	0.9	1.7	1.3	-0.1	1.0
Glaucoma (self-reported)	0.5	0.6	1.1	1.1	-0.7	-0.4
Medication: Amlodipine	0.5	0.7	1.5	1.2	-0.8	-0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.3	1.1	0.7	0.4
Wheeze or whistling in the chest in last year	0.5	0.9	2.4	1.6	-0.0	-0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	1.9	0.6	0.4	1.4
Loneliness, isolation	0.5	0.7	1.3	-1.1	-0.2	-0.9
Eye problems/disorders: Cataract	0.5	0.6	0.7	0.8	0.7	-0.8
Asthma (self-reported)	0.5	1.0	2.1	1.4	0.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.2	0.1	-1.8	0.0
Hearing aid user	0.5	0.6	1.3	-0.4	-0.6	-1.1
Financial situation satisfaction	0.5	0.6	1.7	0.2	0.2	-1.3
Commuting to job workplace: Public transport	0.5	0.6	1.5	-1.2	-0.4	-0.3
Medication: Atorvastatin	0.5	0.6	1.3	-0.5	-0.5	-1.1
Irritability	0.5	0.8	2.3	1.5	0.1	-0.4
Myopia	0.5	0.7	1.5	-1.2	-0.4	0.6
Schizophrenia (2018)	0.4	0.9	1.5	-0.5	1.2	-1.0
Age at First Birth	0.4	0.5	1.0	-0.1	-0.8	1.0
Hypothyroidism (self reported)	0.4	0.9	2.4	1.5	0.1	-0.5
Respiratory disease	0.4	0.9	2.3	1.5	-0.2	0.6
Number of treatments/medications taken	0.4	0.8	1.1	-1.1	0.5	-1.0
Sensitivity / hurt feelings	0.4	0.7	1.7	1.3	0.2	0.7
High blood pressure (mother)	0.4	0.6	1.1	0.8	-0.0	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.5	-1.2	-0.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.8	-0.3	0.9	-0.7
Birth weight of first child	0.4	0.7	2.1	-0.1	0.2	1.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	1.5	0.3	0.0
Worry too long after embarrassment	0.4	0.7	1.7	0.4	1.3	-0.4
Age at first live birth	0.4	0.8	1.5	0.2	0.9	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	0.8	-0.3	0.9	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.4	1.2	-0.8	-0.2
Miserableness	0.4	0.8	1.9	0.6	0.3	-1.4
Medication: Blood pressure	0.4	0.8	2.1	-0.4	1.5	-0.3
Alcohol drinker status: Never	0.4	0.5	1.3	0.2	-0.3	1.1
Pack years of smoking	0.4	0.6	1.8	-0.0	-0.3	-1.3
Bipolar Disorder (2018)	0.3	0.4	1.0	0.5	-1.0	0.1
Breast Cancer	0.3	0.7	1.2	-1.1	-0.8	-0.3
LDL Cholesterol	0.3	0.4	1.3	-0.1	-0.0	-1.2
Neuroticism (2016)	0.3	0.4	0.6	-0.8	0.5	-0.6
Primary Biliary Cirrhosis	0.3	0.4	1.0	0.6	-1.0	0.1
Blood Platelet Count	0.3	3.6	8.5	-0.1	1.5	2.9
Heel T-Score	0.3	2.5	6.7	-2.6	-0.9	0.3
Smoking Status	0.3	0.7	1.3	-0.1	1.1	-0.8
Neuroticism	0.3	0.6	1.3	-1.1	0.7	0.2
Chronotype (morning person)	0.3	0.6	1.6	1.3	-0.2	-0.4
Hand grip strength (left)	0.3	0.7	1.9	1.4	-0.2	0.5
Diabetes (mother)	0.3	0.4	0.9	0.9	-0.3	-0.4
Trunk fat percentage	0.3	1.1	3.1	-0.3	1.8	-0.2
Hand grip strength (right)	0.3	0.8	1.0	1.0	-0.8	1.0
Neuroticism score	0.3	0.7	1.5	-1.2	0.3	-0.7
Hair/balding pattern: Pattern 3	0.3	0.4	0.9	-0.6	-0.3	-1.0
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.1	0.1	-0.3	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	1.0	0.2	0.1	-1.0
Number of children fathered	0.3	0.4	0.9	-0.4	0.1	-1.0
Qualifications: College or University degree	0.3	0.9	2.3	-0.2	0.6	1.5
Eye problems/disorders: None of the above	0.3	0.3	0.6	0.2	0.8	0.5
Medication: Ibuprofen	0.3	0.3	0.8	-0.5	0.1	0.9
Medication: Allopurinol	0.3	0.4	0.7	-0.6	0.3	0.8
Hypertension (Self-reported)	0.3	0.8	1.7	-0.7	0.6	-1.3
Osteoporosis (self-reported)	0.3	0.3	0.7	0.3	0.8	0.4
Diastolic blood pressure, automated reading	0.3	0.9	1.9	0.4	1.4	-0.8
Depressed Affect (Nagel 2018)	0.2	0.5	1.0	0.6	-0.4	-1.0
Neuroticism (Nagel 2018)	0.2	0.4	1.1	0.2	-0.3	-1.1
Alzheimer’s Disease (in father)	0.2	0.2	0.4	-0.4	0.2	0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	-0.0	1.1	0.4
Ulcerative Colitis (UC)	0.2	0.4	0.6	-0.8	0.8	0.3
Bipolar Disorder (2011)	0.2	0.2	0.4	0.2	-0.5	0.6
Schizophrenia (2014)	0.2	0.3	0.5	-0.6	0.7	-0.4
Blood Red Count	0.2	1.7	3.0	-1.5	0.2	1.7
BMI	0.2	1.4	4.1	-0.3	-2.0	-0.4
Waist Hip Ratio (WHR)	0.2	0.7	1.5	0.8	1.2	-0.2
Cardiovascular Disease	0.2	0.8	1.0	-0.9	0.7	-1.0
Lung FEV1/FVC ratio	0.2	1.0	2.7	-1.6	0.2	-0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	0.5	0.1	-0.5
Systolic blood pressure, automated reading	0.2	0.5	0.8	-0.5	0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.8	-0.3	-0.7	0.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.4	-0.6	-0.4	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	-0.6	0.9	-0.0
Allergy	0.2	0.4	0.7	-0.5	-0.9	0.4
Arm fat percentage (right)	0.2	0.7	1.9	0.2	1.4	0.3
Length of working week for main job	0.2	0.2	0.5	-0.7	-0.0	0.2
Body fat percentage	0.2	1.0	2.9	-0.2	1.7	-0.1
Medication: Blood pressure	0.2	0.4	0.9	-0.4	-0.3	-1.0
Pulse rate, automated reading	0.2	0.8	1.6	0.7	0.6	-1.2
Guilty feelings	0.2	0.4	0.8	-0.4	-0.1	0.9
Medication: Bendroflumethiazide	0.2	0.3	0.8	0.4	0.2	0.9
Medication: Paracetamol	0.2	0.3	0.5	-0.4	-0.5	-0.7
Leg fat percentage (left)	0.2	0.6	1.2	-1.1	0.7	-0.1
Average weekly beer plus cider intake	0.2	0.2	0.6	0.3	-0.2	-0.8
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.8	0.2	0.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.1	0.3	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.8	0.3	-0.9	0.6
Crohns Disease (2017)	0.1	0.3	0.6	0.6	0.8	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.7	0.9	-0.4	0.2
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.3	0.3	0.0
HbA1C	0.1	0.1	0.3	0.4	-0.0	-0.5
HDL Cholesterol	0.1	0.1	0.2	-0.4	0.3	-0.2
Triglycerides	0.1	0.1	0.3	-0.2	-0.5	-0.4
Blood White Count	0.1	0.7	1.3	1.2	0.7	-0.6
Systolic Blood Pressure	0.1	0.6	1.8	-0.2	1.3	0.2
Allergy or Eczema	0.1	0.2	0.6	-0.3	0.7	-0.3
Lung FVC	0.1	0.6	1.2	-0.4	-1.1	-0.7
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.1	-0.4	0.3
Multivitamins +/- minerals	0.1	0.1	0.4	0.1	0.6	-0.1
Body mass index (BMI)	0.1	0.3	0.5	-0.5	-0.7	-0.2
Trunk fat mass	0.1	0.2	0.4	-0.5	-0.0	-0.7
Waist circumference	0.1	0.4	0.5	-0.6	-0.7	-0.6
Number of incorrect matches in round	0.1	0.1	0.1	-0.3	0.2	0.3
Had menopause	0.1	0.2	0.3	0.4	0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	-0.4	-0.1	0.8
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.3	0.5	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	-0.3	-0.1	0.5
Medication: Lansoprazole	0.1	0.1	0.1	-0.2	-0.1	-0.3
Arm fat mass (right)	0.1	0.3	0.5	-0.3	-0.6	-0.7
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.5	0.0	0.5
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.1	-0.1	0.6
Medication: Paracetamol	0.1	0.1	0.2	-0.1	-0.5	-0.3
Gout (self-reported)	0.1	0.2	0.5	0.0	-0.1	0.7
Leg fat percentage (right)	0.1	0.4	0.8	-0.7	0.9	-0.2
Whole body fat mass	0.1	0.3	0.5	-0.6	-0.3	-0.7
Leg fat mass (right)	0.1	0.5	0.8	-0.9	-0.6	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	-0.4	0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.3	0.6	-0.2	0.3
Arm fat percentage (left)	0.1	0.5	1.4	0.3	1.2	0.3
Mood swings	0.1	0.1	0.2	-0.3	0.4	0.1
Arm fat mass (left)	0.1	0.3	0.4	-0.4	-0.6	-0.6
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.5	-0.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.5	0.2	-0.0	0.7
Heart disease (siblings)	0.1	0.1	0.1	0.1	0.4	-0.2
Leg fat mass (left)	0.1	0.5	1.0	-1.0	-0.6	-0.4
Hair Pigment	0.0	0.1	0.1	-0.2	0.3	0.1
Tanning	0.0	0.3	0.9	0.1	-0.2	0.9
Qualifications: CSEs or equivalent	0.0	0.0	0.1	0.3	0.1	-0.1
Happiness	0.0	0.0	0.1	0.1	0.3	-0.1
Peak expiratory flow (PEF)	0.0	0.1	0.2	0.1	0.2	0.4
Heart disease (mother)	0.0	0.0	0.0	-0.2	-0.0	-0.1
Number of operations (self-reported)	0.0	0.0	0.1	-0.2	-0.3	0.1

Hub : Genes

CRNKL1

Models

Trait associations