Best TWAS P=1.58e-10 · Best GWAS P=2.17e-13 conditioned to 2.93e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | FRZB | 0.14 | 0.04 | enet | 16 | 0.05 | 9.6e-05 | -2.6 | -5.2 | 2.4e-07 | 0.27 | 0.92 | 0.01 | FALSE |
| 2 | GTEx | Brain Hypothalamus | PDE1A | 0.24 | -0.01 | enet | 21 | -0.01 | 7.6e-01 | 5.4 | 6.4 | 1.6e-10 | -0.53 | 0.05 | 0.46 | TRUE |
| 3 | GTEx | Liver | NCKAP1 | 0.50 | -0.01 | lasso | 10 | 0.01 | 1.4e-01 | 4.9 | 5.9 | 4.7e-09 | -0.07 | 0.05 | 0.14 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | PDE1A | 0.11 | 0.03 | bslmm | 526 | 0.06 | 3.2e-08 | -7.0 | 5.2 | 2.6e-07 | -0.49 | 0.02 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PDE1A | 0.05 | 0.04 | blup | 206 | 0.04 | 5.0e-05 | -5.0 | 5.5 | 3.8e-08 | -0.41 | 0.64 | 0.03 | FALSE |