Best TWAS P=2.59e-15 · Best GWAS P=3.26e-25 conditioned to 8.45e-10
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | BCS1L | 0.06 | 0.01 | enet | 9 | 0.04 | 2.3e-04 | -2.7 | 5.8 | 7.6e-09 | -0.04 | 0.07 | 0.23 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | PNKD | 0.11 | 0.00 | enet | 31 | 0.00 | 2.3e-01 | -6.1 | 6.3 | 3.6e-10 | 0.06 | 0.01 | 0.93 | TRUE |
| 3 | GTEx | Adrenal Gland | PNKD | 0.20 | 0.16 | lasso | 5 | 0.19 | 1.6e-07 | -5.1 | 5.4 | 6.5e-08 | 0.07 | 0.03 | 0.96 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | RP11-378A13.1 | 0.53 | 0.57 | enet | 24 | 0.60 | 3.3e-19 | -4.9 | 5.3 | 1.4e-07 | 0.07 | 0.05 | 0.95 | FALSE |
| 5 | GTEx | Brain Hypothalamus | RP11-378A13.1 | 0.37 | 0.44 | enet | 17 | 0.45 | 5.6e-12 | -4.9 | 5.5 | 5.2e-08 | 0.10 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Lung | PNKD | 0.13 | 0.04 | enet | 10 | 0.03 | 3.7e-03 | -5.6 | 5.5 | 4.7e-08 | 0.08 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Pancreas | PNKD | 0.12 | 0.10 | lasso | 3 | 0.08 | 3.6e-04 | -6.1 | 5.7 | 1.2e-08 | 0.05 | 0.00 | 0.97 | FALSE |
| 8 | GTEx | Pituitary | PNKD | 0.29 | 0.23 | enet | 21 | 0.24 | 8.9e-07 | -6.1 | 5.9 | 4.8e-09 | 0.09 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | PNKD | 0.28 | 0.28 | enet | 9 | 0.26 | 9.7e-15 | -5.0 | 5.2 | 1.8e-07 | 0.08 | 0.21 | 0.79 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-378A13.1 | 0.26 | 0.25 | lasso | 8 | 0.28 | 5.6e-16 | -5.1 | 5.1 | 2.8e-07 | 0.08 | 0.27 | 0.72 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | PNKD | 0.27 | 0.29 | lasso | 8 | 0.34 | 3.9e-29 | -5.1 | 5.2 | 2.0e-07 | 0.08 | 0.24 | 0.76 | FALSE |
| 12 | GTEx | Small Intestine Terminal Ileum | RP11-378A13.1 | 0.39 | 0.17 | enet | 15 | 0.14 | 4.5e-04 | -5.0 | 5.1 | 2.8e-07 | 0.06 | 0.03 | 0.93 | FALSE |
| 13 | GTEx | Thyroid | PNKD | 0.13 | 0.12 | enet | 13 | 0.14 | 6.3e-11 | -6.1 | 5.3 | 1.1e-07 | 0.07 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Thyroid | RP11-378A13.1 | 0.31 | 0.34 | enet | 34 | 0.38 | 3.7e-30 | -4.9 | 5.1 | 2.9e-07 | 0.10 | 0.10 | 0.90 | FALSE |
| 15 | GTEx | Whole Blood | PNKD | 0.05 | 0.04 | lasso | 3 | 0.03 | 4.4e-04 | -4.9 | 5.2 | 2.1e-07 | 0.10 | 0.05 | 0.93 | FALSE |
| 16 | METSIM | Adipose | PNKD | 0.07 | 0.08 | lasso | 7 | 0.08 | 4.8e-12 | -6.1 | 6.0 | 2.5e-09 | 0.07 | 0.00 | 1.00 | FALSE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | DIRC3 | 0.12 | 0.07 | bslmm | 697 | 0.08 | 2.7e-10 | -6.8 | 7.0 | 2.5e-12 | 0.00 | 1.00 | 0.00 | TRUE |
| 18 | YFS | Blood | PNKD | 0.08 | 0.07 | lasso | 6 | 0.09 | 2.9e-27 | -4.4 | 5.6 | 1.7e-08 | 0.05 | 0.04 | 0.96 | FALSE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMBIM1 | 0.04 | 0.01 | blup | 49 | 0.02 | 4.8e-05 | -4.9 | 5.5 | 4.2e-08 | 0.09 | 0.10 | 0.86 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DIRC3 | 0.12 | 0.01 | blup | 275 | 0.02 | 3.3e-03 | -1.1 | 6.1 | 1.1e-09 | -0.51 | 0.05 | 0.52 | TRUE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | DIRC3 | 0.08 | 0.06 | lasso | 5 | 0.07 | 2.7e-07 | -8.4 | 7.9 | 2.6e-15 | -0.56 | 0.98 | 0.01 | TRUE |