[Hub]/) : Traits : Arm fat-free mass (right) : ← →

chr2:217,456,567-220,226,393

Best TWAS P=2.59e-15 · Best GWAS P=3.26e-25 conditioned to 8.45e-10

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
21	The Cancer Genome Atlas	Thyroid Carcinoma	DIRC3	0.08	0.06	lasso	5	0.07	2.7e-07	-8.4	7.9	2.6e-15	-0.56	0.98	0.01	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	DIRC3	0.12	0.07	bslmm	697	0.08	2.7e-10	-6.8	7.0	2.5e-12	0.00	1.00	0.00	TRUE
2	GTEx	Adipose Visceral Omentum	PNKD	0.11	0.00	enet	31	0.00	2.3e-01	-6.1	6.3	3.6e-10	0.06	0.01	0.93	TRUE
20	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DIRC3	0.12	0.01	blup	275	0.02	3.3e-03	-1.1	6.1	1.1e-09	-0.51	0.05	0.52	TRUE
16	METSIM	Adipose	PNKD	0.07	0.08	lasso	7	0.08	4.8e-12	-6.1	6.0	2.5e-09	0.07	0.00	1.00	FALSE
8	GTEx	Pituitary	PNKD	0.29	0.23	enet	21	0.24	8.9e-07	-6.1	5.9	4.8e-09	0.09	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	BCS1L	0.06	0.01	enet	9	0.04	2.3e-04	-2.7	5.8	7.6e-09	-0.04	0.07	0.23	FALSE
7	GTEx	Pancreas	PNKD	0.12	0.10	lasso	3	0.08	3.6e-04	-6.1	5.7	1.2e-08	0.05	0.00	0.97	FALSE
18	YFS	Blood	PNKD	0.08	0.07	lasso	6	0.09	2.9e-27	-4.4	5.6	1.7e-08	0.05	0.04	0.96	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMBIM1	0.04	0.01	blup	49	0.02	4.8e-05	-4.9	5.5	4.2e-08	0.09	0.10	0.86	FALSE
6	GTEx	Lung	PNKD	0.13	0.04	enet	10	0.03	3.7e-03	-5.6	5.5	4.7e-08	0.08	0.02	0.98	FALSE
5	GTEx	Brain Hypothalamus	RP11-378A13.1	0.37	0.44	enet	17	0.45	5.6e-12	-4.9	5.5	5.2e-08	0.10	0.01	0.99	FALSE
3	GTEx	Adrenal Gland	PNKD	0.20	0.16	lasso	5	0.19	1.6e-07	-5.1	5.4	6.5e-08	0.07	0.03	0.96	FALSE
13	GTEx	Thyroid	PNKD	0.13	0.12	enet	13	0.14	6.3e-11	-6.1	5.3	1.1e-07	0.07	0.00	1.00	FALSE
4	GTEx	Brain Cerebellar Hemisphere	RP11-378A13.1	0.53	0.57	enet	24	0.60	3.3e-19	-4.9	5.3	1.4e-07	0.07	0.05	0.95	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	PNKD	0.28	0.28	enet	9	0.26	9.7e-15	-5.0	5.2	1.8e-07	0.08	0.21	0.79	FALSE
11	GTEx	Skin Sun Exposed Lower leg	PNKD	0.27	0.29	lasso	8	0.34	3.9e-29	-5.1	5.2	2.0e-07	0.08	0.24	0.76	FALSE
15	GTEx	Whole Blood	PNKD	0.05	0.04	lasso	3	0.03	4.4e-04	-4.9	5.2	2.1e-07	0.10	0.05	0.93	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	RP11-378A13.1	0.26	0.25	lasso	8	0.28	5.6e-16	-5.1	5.1	2.8e-07	0.08	0.27	0.72	FALSE
12	GTEx	Small Intestine Terminal Ileum	RP11-378A13.1	0.39	0.17	enet	15	0.14	4.5e-04	-5.0	5.1	2.8e-07	0.06	0.03	0.93	FALSE
14	GTEx	Thyroid	RP11-378A13.1	0.31	0.34	enet	34	0.38	3.7e-30	-4.9	5.1	2.9e-07	0.10	0.10	0.90	FALSE