Best TWAS P=1.1e-10 · Best GWAS P=7.37e-10 conditioned to 0.0848
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DHX36 | 0.05 | 0.06 | blup | 357 | 0.05 | 1.3e-06 | -4.7 | -5.8 | 7.5e-09 | -0.48 | 0.91 | 0.08 | FALSE |
| 2 | GTEx | Ovary | ARHGEF26 | 0.14 | 0.03 | enet | 15 | 0.06 | 1.4e-02 | 6.0 | 6.5 | 1.1e-10 | 0.79 | 0.05 | 0.65 | TRUE |
| 3 | GTEx | Pancreas | ARHGEF26 | 0.26 | 0.26 | lasso | 5 | 0.28 | 3.2e-12 | -4.7 | 5.6 | 2.7e-08 | 0.44 | 0.89 | 0.11 | FALSE |
| 4 | GTEx | Spleen | DHX36 | 0.39 | 0.09 | enet | 21 | 0.34 | 2.1e-09 | -3.3 | -5.4 | 7.6e-08 | -0.67 | 0.12 | 0.86 | FALSE |
| 5 | GTEx | Thyroid | ARHGEF26 | 0.09 | 0.07 | enet | 17 | 0.08 | 1.9e-06 | -4.9 | 5.7 | 1.4e-08 | 0.42 | 0.77 | 0.17 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGEF | 0.04 | 0.04 | enet | 12 | 0.04 | 1.1e-05 | -4.5 | 5.6 | 2.6e-08 | 0.48 | 0.36 | 0.51 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DHX36 | 0.11 | 0.09 | enet | 11 | 0.10 | 6.4e-12 | -4.3 | -5.4 | 8.5e-08 | -0.57 | 0.98 | 0.02 | FALSE |
| 8 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DHX36 | 0.05 | 0.00 | enet | 9 | 0.01 | 1.0e-01 | -4.2 | -5.1 | 2.9e-07 | -0.78 | 0.01 | 0.61 | FALSE |