Best TWAS P=5.91e-09 · Best GWAS P=2.28e-07 conditioned to 0.0462
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | SLC51A | 0.28 | 0.17 | lasso | 9 | 0.21 | 4.3e-16 | 4.8 | -5.3 | 1.2e-07 | 0.63 | 0.02 | 0.97 | FALSE |
2 | GTEx | Breast Mammary Tissue | PCYT1A | 0.11 | 0.03 | lasso | 3 | 0.00 | 3.9e-01 | 5.1 | -5.4 | 7.3e-08 | 0.60 | 0.02 | 0.77 | FALSE |
3 | GTEx | Breast Mammary Tissue | SLC51A | 0.28 | 0.06 | lasso | 6 | 0.14 | 1.3e-07 | 3.7 | -5.7 | 1.6e-08 | 0.70 | 0.01 | 0.97 | FALSE |
4 | GTEx | Breast Mammary Tissue | UBXN7 | 0.20 | 0.00 | enet | 16 | 0.02 | 3.5e-02 | -4.2 | -5.7 | 1.0e-08 | 0.60 | 0.03 | 0.85 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | SLC51A | 0.30 | 0.22 | lasso | 4 | 0.24 | 5.0e-18 | 3.7 | -5.4 | 6.5e-08 | 0.45 | 0.58 | 0.25 | FALSE |
6 | GTEx | Heart Atrial Appendage | SLC51A | 0.27 | 0.11 | lasso | 4 | 0.15 | 2.9e-07 | 3.7 | -5.4 | 7.2e-08 | 0.73 | 0.03 | 0.96 | FALSE |
7 | GTEx | Nerve Tibial | SLC51A | 0.26 | 0.12 | lasso | 7 | 0.22 | 1.9e-15 | 3.7 | -5.3 | 1.3e-07 | 0.72 | 0.06 | 0.92 | FALSE |
8 | GTEx | Stomach | SLC51A | 0.13 | 0.06 | enet | 12 | 0.03 | 1.9e-02 | 4.8 | -5.8 | 5.9e-09 | 0.62 | 0.02 | 0.92 | TRUE |
9 | GTEx | Thyroid | PCYT1A | 0.09 | 0.01 | enet | 16 | 0.01 | 7.7e-02 | 4.4 | -5.2 | 2.6e-07 | 0.53 | 0.03 | 0.86 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OSTalpha | 0.11 | 0.05 | blup | 52 | 0.10 | 1.4e-11 | 4.8 | -5.2 | 1.7e-07 | 0.64 | 0.01 | 0.99 | FALSE |
11 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PCYT1A | 0.12 | 0.05 | blup | 68 | 0.06 | 2.0e-04 | 4.8 | -5.6 | 1.7e-08 | 0.40 | 0.01 | 0.86 | FALSE |