Best TWAS P=3.81e-18 · Best GWAS P=8.24e-20 conditioned to 0.000452
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -5.5 | -6.2 | 6.3e-10 | 0.61 | 0.08 | 0.88 | FALSE |
| 2 | GTEx | Artery Aorta | PPA2 | 0.11 | -0.01 | enet | 24 | 0.01 | 1.6e-01 | -8.6 | -6.5 | 7.0e-11 | 0.58 | 0.07 | 0.34 | FALSE |
| 3 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -7.3 | -7.3 | 2.7e-13 | 0.79 | 0.07 | 0.50 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | PPA2 | 0.11 | 0.03 | lasso | 3 | 0.01 | 6.5e-02 | -6.0 | -6.6 | 4.4e-11 | 0.59 | 0.42 | 0.10 | FALSE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -8.6 | -8.7 | 3.8e-18 | 0.81 | 0.07 | 0.88 | TRUE |
| 6 | GTEx | Esophagus Mucosa | PPA2 | 0.18 | 0.06 | enet | 14 | 0.12 | 2.5e-08 | 6.8 | -7.6 | 2.3e-14 | 0.68 | 0.12 | 0.87 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | PPA2 | 0.15 | 0.05 | lasso | 7 | 0.06 | 7.4e-04 | -7.4 | -5.7 | 1.3e-08 | 0.70 | 0.24 | 0.37 | FALSE |
| 8 | GTEx | Muscle Skeletal | PPA2 | 0.19 | 0.06 | enet | 28 | 0.11 | 8.7e-11 | -7.3 | -5.2 | 2.1e-07 | 0.67 | 0.78 | 0.21 | FALSE |
| 9 | GTEx | Nerve Tibial | PPA2 | 0.13 | 0.07 | enet | 23 | 0.07 | 2.1e-05 | -6.1 | -6.3 | 3.5e-10 | 0.63 | 0.52 | 0.22 | FALSE |
| 10 | GTEx | Ovary | PPA2 | 0.18 | 0.10 | lasso | 3 | 0.14 | 2.2e-04 | -6.1 | -7.4 | 1.5e-13 | 0.72 | 0.07 | 0.61 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | TET2 | 0.09 | 0.01 | enet | 18 | 0.02 | 3.6e-03 | -8.8 | -5.5 | 3.3e-08 | 0.58 | 0.03 | 0.82 | FALSE |
| 12 | The Cancer Genome Atlas | Thyroid Carcinoma | PPA2 | 0.04 | 0.02 | blup | 84 | 0.04 | 6.1e-05 | -7.3 | -6.6 | 3.6e-11 | 0.74 | 0.14 | 0.66 | FALSE |