TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Arm fat-free mass (right)
:
←
→
chr4:144,882,744-146,788,825
Best TWAS P=2.19e-31 · Best GWAS P=5.09e-40 conditioned to 0.463
145M
145.5M
146M
146.5M
0
10
20
30
40
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
ROSMAP
Brain Pre-frontal Cortex
OTUD4
0.04
0.03
lasso
2
0.03
1.4e-04
11.4
-11.7
2.2e-31
0.64
0.32
0.53
TRUE
3
GTEx
Pancreas
ANAPC10
0.14
0.10
lasso
3
0.10
4.3e-05
-11.3
11.1
1.6e-28
-0.62
0.34
0.06
TRUE
2
GTEx
Brain Hypothalamus
HHIP-AS1
0.12
0.02
enet
16
0.04
4.6e-02
7.9
8.2
2.5e-16
-0.57
0.04
0.46
TRUE
1
CommonMind
Brain Pre-frontal Cortex
OTUD4
0.06
0.04
bslmm
272
0.04
2.6e-05
-10.3
-8.5
2.8e-17
0.72
0.25
0.72
FALSE