Best TWAS P=1.79e-08 · Best GWAS P=1.96e-21 conditioned to 2.28e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | SYNE1 | 0.12 | 0.01 | blup | 875 | 0.05 | 6.9e-07 | 1.6 | 5.6 | 1.8e-08 | 0.26 | 0.64 | 0.08 | TRUE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RGS17 | 0.02 | 0.02 | enet | 5 | 0.02 | 1.8e-04 | 5.3 | -5.3 | 1.2e-07 | 0.02 | 0.01 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Lung Adenocarcinoma | RMND1 | 0.05 | 0.06 | lasso | 2 | 0.07 | 4.3e-08 | 5.8 | -5.4 | 6.5e-08 | -0.04 | 0.00 | 1.00 | TRUE |
| 4 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RMND1 | 0.16 | 0.15 | enet | 7 | 0.09 | 2.7e-03 | 5.8 | -5.2 | 1.9e-07 | -0.04 | 0.00 | 0.95 | FALSE |