Best TWAS P=3.88e-51 · Best GWAS P=5.64e-46 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CDK6 | 0.12 | 0.10 | lasso | 2 | 0.10 | 1.9e-12 | 13.98 | 14.0 | 1.9e-44 | 0.89 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adipose Visceral Omentum | GATAD1 | 0.12 | 0.08 | lasso | 5 | 0.06 | 7.5e-04 | 6.74 | -6.8 | 1.5e-11 | -0.51 | 0.81 | 0.07 | FALSE |
3 | GTEx | Adrenal Gland | GATAD1 | 0.40 | 0.22 | lasso | 7 | 0.25 | 2.0e-09 | 6.74 | -7.5 | 4.3e-14 | -0.57 | 0.63 | 0.13 | FALSE |
4 | GTEx | Artery Aorta | KRIT1 | 0.15 | 0.00 | enet | 24 | 0.03 | 1.3e-02 | 0.74 | -6.2 | 4.9e-10 | -0.27 | 0.12 | 0.05 | FALSE |
5 | GTEx | Artery Aorta | GATAD1 | 0.09 | 0.08 | enet | 4 | 0.07 | 7.4e-05 | 6.74 | -6.7 | 2.0e-11 | -0.49 | 0.50 | 0.08 | FALSE |
6 | GTEx | Artery Coronary | GATAD1 | 0.12 | 0.15 | lasso | 3 | 0.12 | 8.0e-05 | 6.96 | -7.2 | 8.8e-13 | -0.54 | 0.18 | 0.25 | FALSE |
7 | GTEx | Artery Tibial | GATAD1 | 0.14 | 0.04 | enet | 17 | 0.04 | 4.1e-04 | 6.74 | -7.0 | 3.2e-12 | -0.45 | 0.69 | 0.12 | FALSE |
8 | GTEx | Artery Tibial | AC007566.10 | 0.13 | 0.04 | lasso | 5 | 0.00 | 3.1e-01 | 5.71 | -6.3 | 2.2e-10 | -0.10 | 0.08 | 0.04 | FALSE |
9 | GTEx | Brain Caudate basal ganglia | GATAD1 | 0.21 | 0.09 | lasso | 4 | 0.08 | 2.3e-03 | 5.33 | -7.8 | 9.3e-15 | -0.56 | 0.06 | 0.44 | FALSE |
10 | GTEx | Breast Mammary Tissue (Female) | AC007566.10 | 0.04 | -0.01 | lasso | 2 | 0.01 | 2.0e-01 | 1.13 | -6.8 | 1.3e-11 | -0.32 | 0.03 | 0.19 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | GATAD1 | 0.23 | 0.20 | lasso | 4 | 0.22 | 1.4e-16 | 6.74 | -9.1 | 8.0e-20 | -0.69 | 0.94 | 0.06 | FALSE |
12 | GTEx | Colon Transverse | GATAD1 | 0.13 | 0.00 | enet | 16 | 0.05 | 3.0e-03 | 6.74 | -7.8 | 4.7e-15 | -0.52 | 0.18 | 0.25 | FALSE |
13 | GTEx | Esophagus Mucosa | GATAD1 | 0.16 | 0.05 | enet | 16 | 0.08 | 7.3e-06 | 6.74 | -7.2 | 5.9e-13 | -0.46 | 0.72 | 0.16 | FALSE |
14 | GTEx | Esophagus Muscularis | GATAD1 | 0.18 | 0.10 | enet | 33 | 0.13 | 1.6e-08 | 6.74 | -5.8 | 6.4e-09 | -0.38 | 0.97 | 0.00 | FALSE |
15 | GTEx | Esophagus Muscularis | FAM133B | 0.07 | 0.01 | enet | 2 | 0.01 | 1.2e-01 | -9.54 | -9.5 | 2.5e-21 | -0.55 | 0.07 | 0.34 | FALSE |
16 | GTEx | Lung | GATAD1 | 0.15 | 0.12 | lasso | 2 | 0.11 | 1.1e-08 | 6.74 | -6.7 | 1.8e-11 | -0.53 | 0.99 | 0.00 | FALSE |
17 | GTEx | Muscle Skeletal | PEX1 | 0.06 | 0.03 | lasso | 5 | 0.02 | 2.7e-03 | 5.72 | 6.2 | 7.4e-10 | 0.42 | 0.45 | 0.27 | FALSE |
18 | GTEx | Muscle Skeletal | GATAD1 | 0.05 | 0.00 | enet | 13 | 0.01 | 2.4e-02 | 2.90 | -6.9 | 5.9e-12 | -0.44 | 0.46 | 0.05 | FALSE |
19 | GTEx | Nerve Tibial | GATAD1 | 0.30 | 0.19 | lasso | 5 | 0.23 | 1.8e-16 | 6.74 | -5.2 | 2.7e-07 | -0.44 | 1.00 | 0.00 | FALSE |
20 | GTEx | Pancreas | GATAD1 | 0.12 | 0.13 | lasso | 2 | 0.14 | 2.0e-06 | 6.74 | -6.1 | 1.3e-09 | -0.49 | 0.11 | 0.67 | FALSE |
21 | GTEx | Skin Not Sun Exposed Suprapubic | GATAD1 | 0.22 | 0.27 | lasso | 4 | 0.26 | 1.1e-14 | 6.74 | -6.9 | 4.9e-12 | -0.53 | 1.00 | 0.00 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | PEX1 | 0.18 | 0.06 | enet | 41 | 0.03 | 1.5e-03 | -7.69 | -8.0 | 1.3e-15 | -0.44 | 0.20 | 0.15 | FALSE |
23 | GTEx | Skin Sun Exposed Lower leg | GATAD1 | 0.30 | 0.10 | enet | 14 | 0.16 | 7.0e-13 | 6.74 | -6.8 | 1.3e-11 | -0.44 | 1.00 | 0.00 | FALSE |
24 | GTEx | Spleen | PEX1 | 0.18 | 0.00 | enet | 38 | 0.05 | 2.4e-02 | 3.67 | -7.2 | 7.8e-13 | -0.38 | 0.08 | 0.11 | FALSE |
25 | GTEx | Stomach | GATAD1 | 0.30 | 0.13 | lasso | 5 | 0.15 | 8.6e-08 | 6.74 | -6.8 | 9.6e-12 | -0.52 | 0.97 | 0.00 | FALSE |
26 | GTEx | Testis | CDK6 | 0.10 | 0.10 | lasso | 3 | 0.09 | 8.0e-05 | 14.23 | -15.0 | 3.9e-51 | -0.96 | 0.01 | 0.99 | TRUE |
27 | GTEx | Thyroid | GATAD1 | 0.18 | 0.06 | lasso | 4 | 0.06 | 3.3e-05 | 6.74 | -6.6 | 5.4e-11 | -0.48 | 0.95 | 0.02 | FALSE |
28 | METSIM | Adipose | GATAD1 | 0.10 | 0.05 | lasso | 7 | 0.06 | 9.4e-10 | 2.90 | -5.1 | 2.9e-07 | -0.40 | 1.00 | 0.00 | FALSE |
29 | ROSMAP | Brain Pre-frontal Cortex | KRIT1 | 0.04 | 0.03 | bslmm | 311 | 0.01 | 9.0e-03 | 3.67 | 7.0 | 2.6e-12 | 0.51 | 0.74 | 0.06 | FALSE |
30 | ROSMAP | Brain Pre-frontal Cortex | GATAD1 | 0.17 | 0.15 | lasso | 4 | 0.16 | 6.0e-20 | 6.84 | -6.8 | 7.3e-12 | -0.51 | 1.00 | 0.00 | FALSE |
31 | YFS | Blood | GATAD1 | 0.01 | 0.01 | blup | 297 | 0.01 | 5.1e-04 | 6.74 | -8.8 | 9.4e-19 | -0.53 | 0.74 | 0.09 | FALSE |
32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GATAD1 | 0.06 | 0.04 | lasso | 6 | 0.04 | 2.2e-09 | 6.54 | -6.2 | 6.0e-10 | -0.40 | 0.60 | 0.40 | FALSE |
33 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GATAD1 | 0.04 | 0.04 | lasso | 2 | 0.03 | 2.8e-04 | 6.54 | -6.3 | 2.7e-10 | -0.47 | 0.14 | 0.16 | FALSE |
34 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C7orf64 | 0.06 | 0.02 | blup | 36 | 0.02 | 6.0e-02 | 5.84 | 5.2 | 1.9e-07 | 0.42 | 0.04 | 0.06 | FALSE |