Best TWAS P=5.63e-14 · Best GWAS P=8.03e-12 conditioned to 0.115
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | ZCCHC24 | 0.12 | 0.01 | lasso | 6 | 0.03 | 3.4e-03 | 6.07 | 7.5 | 5.6e-14 | 0.78 | 0.02 | 0.94 | TRUE |
| 2 | GTEx | Artery Coronary | RP11-119F19.2 | 0.24 | 0.14 | lasso | 6 | 0.12 | 7.0e-05 | 6.00 | -5.1 | 2.8e-07 | -0.02 | 0.40 | 0.19 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-506M13.3 | 0.12 | 0.06 | lasso | 5 | 0.04 | 3.2e-04 | 4.41 | -5.5 | 3.0e-08 | -0.16 | 0.41 | 0.19 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | ZCCHC24 | 0.09 | 0.00 | enet | 18 | 0.00 | 2.3e-01 | -0.68 | 6.7 | 2.3e-11 | 0.43 | 0.02 | 0.62 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | RP11-342M3.5 | 0.08 | 0.00 | enet | 28 | 0.01 | 7.3e-02 | 0.83 | 5.6 | 2.4e-08 | 0.30 | 0.04 | 0.27 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ZCCHC24 | 0.06 | 0.00 | blup | 89 | 0.01 | 6.2e-02 | 3.92 | 7.3 | 2.9e-13 | 0.41 | 0.01 | 0.11 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZCCHC24 | 0.07 | 0.05 | enet | 9 | 0.04 | 6.7e-05 | 6.64 | 6.8 | 7.3e-12 | 0.95 | 0.00 | 1.00 | FALSE |