Best TWAS P=1.68e-09 · Best GWAS P=8.3e-11 conditioned to 7.98e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | BTBD7 | 0.16 | 0.01 | lasso | 8 | 0.04 | 3.6e-04 | -5.7 | 5.6 | 2.6e-08 | -0.62 | 0.19 | 0.78 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | RPS6KA5 | 0.08 | 0.07 | lasso | 2 | 0.06 | 5.3e-05 | -5.8 | 6.0 | 1.7e-09 | 0.00 | 0.02 | 0.97 | TRUE |
| 3 | GTEx | Colon Sigmoid | RIN3 | 0.24 | 0.17 | lasso | 6 | 0.11 | 9.3e-05 | 5.3 | -5.1 | 2.9e-07 | -0.04 | 0.00 | 0.98 | TRUE |
| 4 | GTEx | Spleen | C14orf159 | 0.30 | 0.21 | lasso | 5 | 0.21 | 3.6e-06 | -5.3 | 5.9 | 3.2e-09 | -0.02 | 0.08 | 0.43 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | RIN3 | 0.05 | 0.00 | blup | 163 | 0.01 | 6.0e-02 | -3.2 | -5.5 | 4.8e-08 | 0.02 | 0.02 | 0.06 | TRUE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | BTBD7 | 0.02 | 0.01 | blup | 72 | 0.02 | 6.8e-03 | -5.5 | 5.2 | 2.2e-07 | -0.57 | 0.01 | 0.88 | FALSE |
| 7 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | BTBD7 | 0.11 | 0.03 | blup | 72 | 0.02 | 8.0e-02 | -5.7 | 5.6 | 2.2e-08 | -0.63 | 0.02 | 0.80 | TRUE |