Best TWAS P=3.6e-10 · Best GWAS P=1.49e-09 conditioned to 0.0357
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | DCAF4 | 0.23 | 0.07 | enet | 30 | 0.13 | 4.3e-07 | 4.4 | 5.4 | 5.7e-08 | 0.48 | 0.16 | 0.82 | FALSE |
| 2 | GTEx | Colon Sigmoid | DCAF4 | 0.30 | 0.10 | lasso | 9 | 0.11 | 1.3e-04 | 5.4 | 6.3 | 3.6e-10 | 0.74 | 0.01 | 0.93 | TRUE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | DCAF4 | 0.18 | 0.01 | enet | 10 | 0.06 | 3.0e-03 | 5.4 | 6.1 | 1.0e-09 | 0.53 | 0.07 | 0.49 | FALSE |
| 4 | GTEx | Esophagus Mucosa | ZFYVE1 | 0.10 | 0.00 | lasso | 7 | 0.00 | 2.0e-01 | 5.4 | 5.9 | 2.7e-09 | 0.61 | 0.10 | 0.67 | FALSE |
| 5 | GTEx | Pancreas | DCAF4 | 0.20 | 0.15 | lasso | 4 | 0.14 | 2.4e-06 | 5.4 | 5.2 | 1.6e-07 | 0.60 | 0.06 | 0.88 | FALSE |
| 6 | GTEx | Spleen | DCAF4 | 0.47 | 0.12 | enet | 10 | 0.19 | 1.5e-05 | 4.5 | 6.0 | 2.6e-09 | 0.63 | 0.11 | 0.84 | FALSE |
| 7 | GTEx | Spleen | NUMB | 0.46 | -0.01 | enet | 28 | 0.09 | 3.2e-03 | 1.5 | 5.5 | 4.0e-08 | 0.48 | 0.08 | 0.28 | FALSE |
| 8 | NTR | Blood | DCAF4 | 0.04 | 0.03 | lasso | 6 | 0.03 | 6.5e-09 | 5.4 | 5.4 | 5.5e-08 | 0.60 | 0.06 | 0.94 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPF3 | 0.18 | 0.18 | lasso | 7 | 0.22 | 1.6e-24 | 5.0 | 5.7 | 1.1e-08 | 0.91 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | DPF3 | 0.10 | 0.02 | blup | 210 | 0.07 | 1.9e-07 | -2.6 | -5.3 | 1.3e-07 | -0.53 | 0.80 | 0.14 | FALSE |