Best TWAS P=2.75e-12 · Best GWAS P=1.18e-09 conditioned to 6.21e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | NTAN1 | 0.05 | 0.03 | lasso | 2 | 0.04 | 6.7e-04 | -5.9 | 6.4 | 1.5e-10 | -0.12 | 0.01 | 0.96 | FALSE |
| 2 | GTEx | Artery Tibial | RRN3 | 0.11 | 0.06 | lasso | 2 | 0.07 | 2.0e-06 | 5.7 | 5.4 | 6.1e-08 | -0.14 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | RRN3 | 0.36 | 0.14 | lasso | 5 | 0.20 | 4.5e-07 | 5.7 | 5.9 | 4.6e-09 | -0.14 | 0.03 | 0.97 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RRN3 | 0.10 | 0.12 | enet | 13 | 0.13 | 6.3e-10 | 5.7 | 6.5 | 1.0e-10 | -0.15 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Colon Transverse | RRN3 | 0.13 | 0.00 | lasso | 5 | 0.00 | 1.9e-01 | 5.5 | -5.8 | 9.0e-09 | 0.11 | 0.02 | 0.40 | FALSE |
| 6 | GTEx | Esophagus Mucosa | RRN3 | 0.13 | 0.13 | lasso | 4 | 0.13 | 3.2e-09 | 5.5 | 5.3 | 9.3e-08 | -0.14 | 0.04 | 0.96 | FALSE |
| 7 | GTEx | Heart Atrial Appendage | NOMO1 | 0.19 | 0.12 | lasso | 6 | 0.10 | 3.7e-05 | 5.5 | 5.6 | 2.8e-08 | -0.15 | 0.05 | 0.84 | FALSE |
| 8 | GTEx | Heart Atrial Appendage | NTAN1 | 0.10 | 0.09 | lasso | 1 | 0.07 | 3.7e-04 | 5.5 | 5.5 | 3.8e-08 | -0.14 | 0.02 | 0.67 | FALSE |
| 9 | GTEx | Heart Left Ventricle | RRN3 | 0.24 | 0.12 | lasso | 7 | 0.17 | 2.2e-09 | 5.5 | -6.5 | 9.9e-11 | 0.11 | 0.04 | 0.95 | FALSE |
| 10 | GTEx | Heart Left Ventricle | NTAN1 | 0.09 | 0.04 | lasso | 3 | 0.02 | 2.0e-02 | 5.7 | 5.6 | 1.9e-08 | -0.14 | 0.02 | 0.77 | FALSE |
| 11 | GTEx | Muscle Skeletal | RRN3 | 0.18 | 0.03 | enet | 17 | 0.11 | 5.7e-11 | 4.7 | -6.2 | 4.7e-10 | 0.09 | 0.17 | 0.71 | FALSE |
| 12 | GTEx | Muscle Skeletal | NTAN1 | 0.12 | 0.07 | lasso | 6 | 0.09 | 1.4e-09 | 5.5 | 6.3 | 2.3e-10 | -0.13 | 0.04 | 0.96 | FALSE |
| 13 | GTEx | Nerve Tibial | NTAN1 | 0.07 | 0.00 | enet | 14 | 0.00 | 1.7e-01 | 5.7 | 6.3 | 2.1e-10 | -0.05 | 0.02 | 0.22 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | RRN3 | 0.10 | 0.12 | lasso | 1 | 0.11 | 4.5e-09 | 5.7 | 5.7 | 1.3e-08 | -0.14 | 0.03 | 0.97 | FALSE |
| 15 | GTEx | Testis | RRN3 | 0.10 | 0.10 | lasso | 2 | 0.07 | 3.9e-04 | 5.7 | 5.7 | 1.3e-08 | -0.14 | 0.03 | 0.78 | FALSE |
| 16 | GTEx | Thyroid | RP11-65J21.3 | 0.35 | 0.32 | lasso | 2 | 0.31 | 2.6e-24 | -5.4 | -5.4 | 5.5e-08 | -0.54 | 0.10 | 0.90 | TRUE |
| 17 | METSIM | Adipose | NTAN1 | 0.07 | 0.06 | enet | 12 | 0.06 | 1.7e-09 | 5.7 | 5.1 | 2.7e-07 | -0.12 | 0.04 | 0.96 | FALSE |
| 18 | NTR | Blood | NTAN1 | 0.01 | 0.00 | bslmm | 110 | 0.00 | 4.2e-02 | 5.7 | 5.8 | 4.9e-09 | -0.09 | 0.01 | 0.19 | FALSE |
| 19 | NTR | Blood | PDXDC1 | 0.12 | 0.12 | enet | 26 | 0.15 | 1.3e-46 | -5.8 | 7.0 | 2.8e-12 | -0.14 | 0.01 | 0.99 | TRUE |
| 20 | ROSMAP | Brain Pre-frontal Cortex | NTAN1 | 0.12 | 0.10 | lasso | 3 | 0.11 | 1.4e-13 | 5.5 | 5.5 | 2.8e-08 | -0.14 | 0.04 | 0.96 | FALSE |