Best TWAS P=5.99e-09 · Best GWAS P=1.07e-08 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | STAU1 | 0.08 | 0.03 | lasso | 6 | 0.02 | 2.3e-02 | 4.8 | 5.2 | 1.8e-07 | 0.78 | 0.08 | 0.78 | FALSE |
| 2 | GTEx | Esophagus Mucosa | CSE1L | 0.09 | 0.06 | lasso | 4 | 0.06 | 6.9e-05 | 5.4 | -5.2 | 2.5e-07 | -0.75 | 0.06 | 0.92 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | CSE1L | 0.08 | 0.03 | lasso | 2 | 0.03 | 9.5e-04 | 5.5 | -5.3 | 1.2e-07 | -0.75 | 0.10 | 0.83 | FALSE |
| 4 | GTEx | Testis | ARFGEF2 | 0.20 | 0.20 | lasso | 7 | 0.24 | 5.4e-11 | 4.8 | -5.4 | 7.6e-08 | -0.84 | 0.11 | 0.89 | FALSE |
| 5 | METSIM | Adipose | ARFGEF2 | 0.04 | 0.03 | lasso | 12 | 0.02 | 9.8e-05 | 5.6 | -5.8 | 6.0e-09 | -0.96 | 0.02 | 0.98 | TRUE |
| 6 | NTR | Blood | SNORD12B | 0.03 | 0.05 | lasso | 8 | 0.05 | 1.9e-14 | 5.7 | -5.8 | 6.6e-09 | -0.98 | 0.01 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ARFGEF2 | 0.05 | 0.04 | lasso | 5 | 0.05 | 3.2e-06 | 5.2 | -5.7 | 1.1e-08 | -0.87 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C20orf199 | 0.05 | 0.06 | lasso | 4 | 0.06 | 1.0e-04 | 5.7 | 5.7 | 1.3e-08 | 1.00 | 0.00 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | DDX27 | 0.08 | 0.05 | lasso | 3 | 0.05 | 1.9e-05 | 5.7 | 5.2 | 1.9e-07 | 0.92 | 0.01 | 0.98 | FALSE |