TWAS hub - C20orf199

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Squamous Cell Carcinoma	0.0424	0.0243	0.00840	0.002	0.008	0.015	NA	0.014	1.8e-01	3.9e-02	0.00640	NA	8.8e-03
2	TCGA	Ovarian Serous Cystadenocarcinoma	0.0530	0.0300	0.00600	0.056	0.044	0.052	NA	0.057	1.2e-04	5.9e-04	0.00020	NA	1.0e-04
3	TCGA	Prostate Adenocarcinoma	0.0818	0.0358	0.00025	0.003	0.037	0.031	NA	0.018	1.6e-01	8.7e-05	0.00028	NA	4.8e-03
4	TCGA	Thyroid Carcinoma	0.0940	0.0430	0.00091	0.046	0.023	0.029	NA	0.042	2.5e-05	2.2e-03	0.00071	NA	5.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Comparative height size at age 10	8.3	45.6	132.2	7.0	11.5	1.1	-0.1
Forced vital capacity (FVC)	8.0	31.0	76.9	6.0	8.8	2.6	-2.2
Forced vital capacity (FVC), Best measure	7.2	26.4	65.4	5.6	8.1	2.3	-1.9
Height	6.7	129.8	346.0	12.8	18.6	2.7	1.4
Standing height	6.5	64.1	178.7	8.6	13.4	1.6	1.3
Happiness	6.0	7.3	9.7	2.8	3.1	2.5	-2.3
Sitting height	5.3	37.8	98.2	6.7	9.9	2.6	1.0
Family relationship satisfaction	5.0	6.2	7.9	2.4	2.8	2.0	-2.7
Intelligence (Savage-Jansen 2018)	4.9	15.0	38.2	3.4	6.2	0.1	3.3
Forced expiratory volume in 1-second (FEV1)	4.6	15.5	42.9	3.8	6.6	1.4	-1.7
Friendships satisfaction	4.6	5.6	7.9	2.3	2.8	2.1	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	4.0	12.9	34.7	3.6	5.9	1.2	-1.6
High blood pressure (mother)	3.9	5.5	12.2	-3.5	-2.6	-1.2	-1.1
Had menopause	3.7	4.7	8.8	3.0	1.9	2.5	-0.4
Trunk fat-free mass	3.7	21.5	54.6	5.3	7.4	0.3	1.8
Trunk predicted mass	3.7	21.1	53.3	5.3	7.3	0.3	1.8
Verbal and Numeric Reasoning (VNR)	3.6	8.7	24.3	2.0	4.9	-0.0	2.5
Bilateral oophorectomy (both ovaries removed)	3.6	4.2	7.9	2.2	1.4	2.8	-1.4
Arm fat percentage (right)	3.5	13.7	33.0	-4.2	-5.7	-1.6	1.1
Qualifications: O levels/GCSEs or equivalent	3.4	5.4	8.0	2.7	2.8	2.5	-0.3
Arm fat percentage (left)	3.3	13.3	33.2	-4.0	-5.8	-1.5	1.3
Loneliness, isolation	3.1	4.3	13.6	1.4	3.7	0.9	0.8
Hand grip strength (right)	3.0	8.3	25.1	2.6	5.0	0.0	1.0
Mean time to correctly identify matches	2.9	5.5	16.0	2.2	4.0	1.1	0.3
Arm predicted mass (right)	2.9	14.7	32.3	4.7	5.7	0.7	2.0
Lung FVC	2.8	14.1	29.7	3.5	5.5	2.4	-3.0
Hearing difficulty/problems with background noise	2.8	4.4	7.7	2.5	2.8	1.8	-0.5
Leg fat percentage (right)	2.8	10.1	26.2	-3.2	-5.1	-1.4	1.4
Arm fat-free mass (right)	2.8	14.2	30.7	4.7	5.5	0.7	2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.7	14.8	2.6	3.8	1.0	0.7
Ever depressed for a whole week	2.8	3.4	7.7	0.4	2.8	-1.5	1.8
Qualifications: NVQ or HND or HNC or equivalent	2.7	3.2	4.6	-2.1	-2.1	-1.7	1.1
Back pain experienced in last month	2.7	4.0	5.6	2.4	1.8	1.9	-1.9
Depression (Nagel 2018)	2.6	3.9	9.8	1.5	3.1	1.7	-0.9
Falls in the last year	2.6	3.5	9.6	0.4	0.7	2.0	-3.1
Medication: Seretide 50 evohaler	2.6	3.0	5.1	1.9	-0.2	1.7	-2.3
Whole body fat-free mass	2.6	14.9	38.3	4.4	6.2	0.2	1.5
Whole body water mass	2.6	14.7	37.3	4.3	6.1	0.2	1.5
Leg fat percentage (left)	2.6	9.5	26.0	-3.1	-5.1	-0.9	1.3
BMI	2.5	14.7	34.7	-3.3	-5.9	-2.2	2.9
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	10.3	1.1	3.2	-0.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.0	14.5	0.7	3.8	0.4	-0.9
Arm fat-free mass (left)	2.5	12.5	28.3	4.4	5.3	0.8	1.4
Body fat percentage	2.4	9.5	23.1	-3.2	-4.8	-1.3	1.7
Financial situation satisfaction	2.4	3.0	5.5	1.8	2.4	1.8	0.1
Arm predicted mass (left)	2.4	12.2	27.7	4.3	5.3	0.7	1.5
Frequency of depressed mood in last 2 weeks	2.3	3.2	9.5	1.4	3.1	1.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	5.4	-2.1	-2.3	-0.8	-1.0
Number of children fathered	2.3	2.6	5.2	-2.1	-2.3	-0.6	-0.6
Smoking status: Previous	2.3	3.4	6.0	1.1	2.3	2.4	-1.1
Birth weight of first child	2.2	4.0	7.7	2.8	2.4	1.1	-1.1
Hand grip strength (left)	2.1	5.5	15.0	2.6	3.9	0.6	0.1
Medication: Ibuprofen	2.1	2.5	4.8	-1.8	-2.2	-0.3	-1.4
Osteoarthritis (self-reported)	2.1	2.8	3.9	-1.8	-1.5	-1.3	2.0
Average weekly champagne plus white wine intake	2.1	2.9	8.6	-1.4	-2.9	-1.0	0.4
Hearing aid user	2.1	2.4	4.1	2.0	1.4	1.8	-0.6
Schizophrenia vs Biploar Disorder	2.0	2.7	4.6	1.6	2.1	1.7	0.8
Bipolar Disorder (2011)	2.0	1.9	3.8	-0.7	-1.9	0.6	-1.7
Qualifications: A levels/AS levels or equivalent	2.0	4.5	14.0	1.9	3.7	0.2	0.6
Ever highly irritable/argumentative for 2 days	2.0	2.4	7.6	1.0	2.8	0.8	-0.5
Heart disease (mother)	2.0	2.4	5.1	1.6	2.3	1.4	-0.3
Triglycerides	1.9	3.2	5.0	-2.2	-1.0	-1.3	2.2
Body mass index (BMI)	1.9	8.0	20.2	-2.8	-4.5	-1.3	1.5
Birth weight	1.9	4.0	8.8	3.0	2.3	1.5	0.3
Pain type(s) experienced in last month: Hip pain	1.9	2.4	3.8	-1.7	-1.2	-1.9	1.2
Basal metabolic rate	1.9	10.5	26.2	3.6	5.1	-0.0	1.7
Average weekly beer plus cider intake	1.9	2.8	7.2	-0.9	-2.7	-1.3	1.1
Mean Putamen Volume	1.8	2.0	3.3	-1.6	-0.6	-1.4	1.8
Respiratory disease	1.8	3.9	5.6	2.4	1.3	2.3	-1.7
Diabetes (mother)	1.8	2.2	3.2	-0.9	-1.6	-1.8	1.5
Had other major operations	1.8	2.2	5.0	-2.2	-1.6	-1.2	0.3
Asthma	1.8	3.5	6.2	1.9	0.7	2.5	-1.9
Exposure to tobacco smoke outside home	1.8	2.5	4.9	-1.2	-1.4	-2.2	1.2
Ever smoked	1.8	3.2	5.8	1.7	2.0	2.4	-0.4
Ovarian Cancer	1.7	2.2	3.7	-0.7	1.9	-1.7	1.3
Body Mass Index (BMI) (2010)	1.7	2.4	4.6	-2.1	-1.8	-0.9	0.9
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.3	-0.9	-1.7	-1.3	1.8
Medication for pain relief, constipation, heartburn	1.7	2.8	6.1	1.8	2.5	-0.4	1.4
Medication: Blood pressure	1.7	3.0	6.6	-2.3	-2.6	0.2	-0.4
Supplements: Vitamin C	1.7	2.0	3.4	1.9	1.7	1.3	-0.3
Qualifications: nursing, teaching	1.7	2.6	7.1	1.0	2.7	-0.6	1.4
Osteoporosis (self-reported)	1.7	2.1	4.5	-1.8	-2.1	-0.7	-0.5
Trunk fat percentage	1.6	6.4	14.8	-2.8	-3.9	-1.1	1.4
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.0	-2.2	-1.4	-0.7	0.1
Mood swings	1.6	2.9	4.5	-2.0	-1.4	-2.1	1.0
Commuting to job workplace: Walk	1.6	1.7	5.6	-0.7	0.5	-0.8	2.4
Alzheimer’s Disease (in father)	1.5	1.6	4.7	1.0	2.2	-0.1	0.8
LDL Cholesterol	1.5	2.4	4.9	-2.2	0.1	-1.7	1.3
Smoking Status	1.5	3.6	5.6	2.0	2.4	2.2	0.5
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.2	2.3	-0.3	1.5	-0.1
Past tobacco smoking	1.5	2.7	5.0	-0.9	-2.2	-2.2	0.7
High blood pressure (siblings)	1.5	2.2	4.5	0.2	-1.0	1.8	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.5	2.3	4.1	1.4	1.6	0.7	-2.0
Illnesses of father: None of the above (group 1)	1.5	1.9	4.4	0.9	0.5	1.4	-2.1
Myopia	1.5	2.2	3.2	-1.0	-1.8	1.2	-1.7
Peak expiratory flow (PEF)	1.4	3.2	10.6	1.3	3.3	0.2	-0.8
Medication: Paracetamol	1.4	2.3	5.4	-1.9	-2.3	-0.4	-0.6
Leg predicted mass (right)	1.4	7.3	19.6	2.9	4.4	-0.1	1.2
Medication: Paracetamol	1.4	2.1	6.3	-1.5	-2.5	-0.1	0.1
Fractured/broken bones in last 5 years	1.4	1.8	4.7	-2.2	-1.1	-1.0	-0.4
Systolic Blood Pressure	1.3	6.3	15.9	-3.1	-4.0	-0.0	-0.1
Medication: Atenolol	1.3	1.7	3.2	-1.8	-1.5	-1.1	-0.3
Qualifications: None of the above	1.3	2.8	8.0	-1.7	-2.8	-0.2	-0.2
Pulse wave Arterial Stiffness index	1.3	1.5	2.2	1.5	1.3	-0.3	1.5
Length of working week for main job	1.3	1.4	3.9	-1.0	-2.0	-0.4	0.6
Angina (self-reported)	1.3	1.7	2.9	-1.7	-0.9	-1.6	0.7
Leg fat-free mass (right)	1.3	7.1	19.2	2.8	4.4	-0.0	1.2
Average weekly red wine intake	1.3	1.9	4.5	1.5	0.2	2.1	-0.8
Vascular/heart problems diagnosed by doctor	1.3	3.6	5.6	2.3	2.4	-0.6	1.7
Heart disease (siblings)	1.3	1.6	2.8	1.5	1.1	1.7	-0.3
Reaction Time	1.2	2.3	8.8	0.4	3.0	0.4	-0.3
Rheumatoid Arthritis	1.2	1.7	5.7	-0.9	-2.4	-0.6	-0.1
Lung FEV1/FVC ratio	1.2	6.3	14.2	-3.8	-2.2	-2.4	0.1
Average weekly fortified wine intake	1.2	1.4	3.1	1.1	1.8	-0.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.5	5.0	0.5	2.2	0.8	-0.5
High blood pressure	1.2	3.3	5.0	-1.9	-2.2	1.4	-1.6
Leg predicted mass (left)	1.2	6.1	16.3	2.5	4.0	-0.3	1.3
Medication: Ramipril	1.2	1.5	3.0	-1.5	-1.7	-0.5	0.8
Medication: Cholesterol lowering	1.2	1.9	3.5	-1.9	-1.0	-0.5	1.7
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.0	2.0	1.9	-0.1	-0.6
Gout (self-reported)	1.2	1.7	2.0	1.4	1.1	1.2	-1.4
Ever had bowel cancer screening	1.2	1.4	2.7	1.6	1.6	0.5	0.4
Asthma (self-reported)	1.2	2.4	4.4	1.6	0.6	2.1	-1.5
Wears glasses or contact lenses	1.2	1.3	2.2	-1.5	-1.0	-1.3	0.6
Ever taken oral contraceptive pill	1.2	1.3	2.6	1.6	1.3	0.9	0.6
Commuting to job workplace: Public transport	1.2	1.5	2.8	1.7	1.4	0.9	0.6
Coronary Artery Disease (CAD)	1.1	1.3	3.5	-0.9	-1.9	-0.8	0.1
Leg fat-free mass (left)	1.1	6.0	15.9	2.5	4.0	-0.4	1.3
Taking other prescription medications	1.1	1.7	3.3	0.7	-1.6	1.8	-0.7
Medication: Levothyroxine sodium	1.1	1.8	5.6	1.1	2.4	0.1	-0.6
Number of incorrect matches in round	1.1	1.8	4.6	-1.1	-2.1	0.7	-0.9
Lung cancer (father)	1.1	1.3	4.5	0.6	0.2	2.1	-0.3
Hypertension (Self-reported)	1.1	2.9	4.0	-2.0	-2.0	1.4	-1.4
Eye problems/disorders: Cataract	1.1	1.3	1.9	1.4	-0.6	1.3	-1.2
Miserableness	1.1	1.8	3.2	1.5	1.8	0.1	1.4
Age at First Birth	1.0	1.4	2.6	0.6	0.7	1.6	-1.5
Blood Red Count	1.0	9.3	21.7	4.7	3.3	1.8	1.1
Hearing difficulty/problems: Yes	1.0	1.5	3.0	1.7	1.4	1.2	0.0
Angina	1.0	1.3	2.5	-1.6	-1.0	-1.3	0.4
Alcohol usually taken with meals	1.0	1.7	3.3	0.8	-0.2	1.8	-1.7
Fluid intelligence score	1.0	2.0	4.9	1.1	2.2	0.5	1.3
Time employed in main current job	1.0	1.2	2.4	-0.3	-1.5	0.0	-1.5
Medication: Lansoprazole	1.0	1.1	3.3	-0.3	-0.4	1.0	-1.8
Arm fat mass (right)	1.0	4.0	8.1	-2.0	-2.8	-1.3	1.5
Medication: Amlodipine	1.0	1.4	3.9	-0.5	0.2	1.3	-2.0
Qualifications: College or University degree	1.0	3.1	9.6	1.3	3.1	-0.9	0.2
Had major operations	1.0	1.2	3.1	-0.7	-0.5	0.9	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.3	0.7	-0.9	1.0	-1.5
Illnesses of siblings: Diabetes	1.0	1.3	4.1	-0.3	0.6	-0.8	2.0
Diastolic blood pressure, automated reading	1.0	3.0	6.2	-2.5	-1.9	-1.5	0.2
Prostate Cancer	0.9	1.3	2.4	-1.3	-1.0	-1.5	0.1
Fasting Glucose	0.9	1.1	2.7	-1.1	-1.6	-0.6	-0.2
Hair/balding pattern: Pattern 3	0.9	1.4	2.7	1.5	1.7	0.1	0.6
Emphysema/chronic bronchitis	0.9	1.0	2.0	0.4	-0.2	1.4	-1.3
Leg fat mass (right)	0.9	3.3	6.8	-1.6	-2.6	-1.0	1.8
Arm fat mass (left)	0.9	3.9	8.7	-1.9	-3.0	-1.0	1.5
Mother’s age at death	0.9	1.1	3.3	0.4	-0.9	1.8	0.3
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.5	1.6	1.2	0.3	0.4
Bipolar Disorder (2018)	0.8	1.2	2.6	-0.7	-1.6	-1.0	0.8
Schizophrenia (2018)	0.8	1.7	2.5	1.6	1.4	0.8	1.2
Schizophrenia (2014)	0.8	1.7	2.6	1.6	1.5	1.1	0.7
Pack years adult smoking proportion	0.8	1.2	2.4	-1.0	-0.7	-1.0	1.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.8	0.3	-0.4	-0.7	1.9
Hair/balding pattern: Pattern 4	0.8	1.9	6.7	0.1	0.1	0.9	-2.6
Loud music exposure frequency	0.8	0.9	2.3	-0.2	-0.1	-1.1	1.5
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.0	-1.4	-1.1	-0.7	0.0
Age at first live birth	0.8	1.5	3.3	-1.8	-0.8	-1.4	0.2
Pulse wave peak to peak time	0.8	0.9	2.3	-0.9	-0.5	0.5	-1.5
Shortness of breath walking on level ground	0.8	0.9	1.7	0.6	-1.3	0.5	-1.2
Number of full sisters	0.8	1.0	3.0	0.6	-0.6	1.7	-0.3
Eye problems/disorders: Glaucoma	0.8	0.9	2.8	0.8	-1.7	-0.4	0.2
Age started oral contraceptive pill	0.8	1.0	2.1	1.5	1.0	0.7	-0.6
Leg fat mass (left)	0.8	3.2	6.9	-1.5	-2.6	-0.8	1.7
Major Depression (MDD)	0.7	0.8	2.3	0.8	1.5	-0.2	0.5
Waist Hip Ratio (WHR)	0.7	2.9	6.7	1.8	2.6	1.2	0.5
Number of treatments/medications taken	0.7	1.3	4.0	-0.9	-2.0	0.7	-0.2
Diabetes (father)	0.7	0.8	1.7	-1.3	-1.0	-0.6	0.3
Qualifications: CSEs or equivalent	0.7	0.9	1.4	-1.0	-1.2	-1.1	0.4
Serious illness, injury or assault to yourself	0.7	0.8	1.6	-0.9	1.3	-0.8	0.6
Financial difficulties in last 2 years	0.7	0.9	2.4	0.5	0.7	0.6	1.6
Heart attack	0.7	0.9	1.9	-1.4	-1.2	-0.3	0.4
Illnesses of mother	0.7	0.9	2.1	1.1	0.4	0.2	1.5
Headache pain in last month	0.7	1.1	2.0	0.7	1.4	-0.1	1.4
Number of full brothers	0.7	0.9	1.9	-0.2	-0.4	1.4	-1.2
Eye problems/disorders: None of the above	0.7	0.8	2.9	-1.7	0.4	-0.4	-0.4
Whole body fat mass	0.7	2.7	5.0	-1.4	-2.2	-0.9	1.8
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.1	-1.0	-1.1	-0.9	-0.2
Number of self-reported non-cancer illnesses	0.7	1.2	2.5	-1.6	-1.5	0.4	0.3
Medication: Bendroflumethiazide	0.7	1.0	1.9	-1.4	-0.7	0.4	-1.2
Irritability	0.7	1.2	4.0	0.6	2.0	0.0	-0.7
Risk taking	0.7	1.0	2.5	-1.6	-0.1	-1.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.6	-0.2	-0.3	0.7	-1.6
Pack years of smoking	0.7	1.0	2.5	-0.8	-0.3	-0.8	1.6
Alzheimer’s Disease (including proxy)	0.6	0.9	1.0	1.0	1.0	1.0	-0.7
Cardiovascular Disease	0.6	2.0	4.2	-2.0	-1.9	0.4	-0.3
Medication for hormone replacement therapy	0.6	0.7	1.6	0.5	-0.9	0.4	1.3
Vitamin and mineral supplements	0.6	0.8	1.6	-1.1	-1.3	-0.5	0.1
Medication: Co-codamol	0.6	0.7	1.6	-0.1	0.9	0.6	-1.3
Severe depression (siblings)	0.6	0.7	1.4	-0.2	-0.6	-1.2	0.9
Supplements: Glucosamine	0.6	0.8	2.2	0.9	0.4	0.3	1.5
Pain all over the body in last month	0.6	0.7	1.0	-0.8	-0.6	-1.0	0.9
Exposure to tobacco smoke at home	0.6	0.6	1.4	-0.6	-1.2	-0.2	0.8
Tense / ‘highly strung’	0.6	0.9	3.2	0.7	1.8	0.2	0.2
Blood clot in the leg (DVT)	0.6	0.8	2.1	-0.5	0.7	-1.4	-0.5
Comparative body size at age 10	0.6	1.7	3.5	-0.7	-1.9	0.3	-1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.2	-0.1	-0.7	-0.2	1.5
Neck or shoulder pain in last month	0.6	0.9	2.0	0.8	0.8	1.4	-0.4
Medication: Omeprazole	0.6	0.8	2.8	0.2	-0.1	0.4	-1.7
Long-standing illness, disability or infirmity	0.6	0.9	2.2	-0.7	0.9	-0.4	1.5
Mineral and other dietary supplements	0.6	0.8	2.0	-1.0	-1.4	-0.6	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.5	0.3	1.9	-1.1	0.0
Alcohol drinker status: Never	0.6	0.7	2.0	0.7	0.2	1.4	-0.2
Number of operations (self-reported)	0.6	0.8	1.7	-0.7	-1.0	0.1	-1.3
Commuting to job workplace: Cycle	0.6	0.7	1.7	-1.3	0.7	-0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.6	-0.3	0.9	-1.3	-0.6
Ulcerative Colitis (UC)	0.5	0.9	3.0	-0.0	0.4	0.5	-1.7
Breast Cancer	0.5	1.2	3.0	-0.7	0.3	-1.0	1.7
HbA1C	0.5	0.5	1.9	1.4	-0.2	0.3	-0.3
Allergy or Eczema	0.5	1.3	2.3	1.5	0.9	0.4	1.4
Average weekly spirits intake	0.5	0.7	1.3	-0.6	0.8	-1.1	0.7
Systolic blood pressure, automated reading	0.5	1.6	3.8	-1.1	-2.0	-0.3	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.1	-0.9	-1.3	-1.4	0.2
Medication: Simvastatin	0.5	0.8	1.8	-0.0	-1.2	-0.2	1.3
Illnesses of siblings	0.5	0.7	1.9	-0.6	-0.2	-1.4	0.7
Pulse wave reflection index	0.5	0.7	1.2	-0.0	0.9	-0.8	1.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.9	0.5	1.7	-0.7	-0.0
Health satisfaction	0.5	0.7	1.2	-0.9	-0.7	0.7	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	0.7	0.4	1.1	0.8
Leg pain on walking	0.5	0.7	2.1	-0.1	0.6	0.4	-1.5
Medication for cholesterol	0.5	0.8	1.7	-0.4	1.3	-0.5	-1.1
Breast cancer (self-reported)	0.5	0.6	1.7	-0.3	0.7	-0.5	1.3
Medication: Atorvastatin	0.5	0.6	1.4	-0.5	-0.0	0.9	-1.2
Unable to work because of sickness or disability	0.5	0.7	1.2	-0.7	0.9	-1.1	0.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.4	-1.2	-0.9	-0.3	0.5
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	0.8	0.1	0.9	-0.6
Lupus	0.4	0.6	1.2	-0.0	1.1	0.3	-1.1
Neuroticism (2016)	0.4	0.6	1.6	1.3	0.7	0.1	0.5
Blood Eosinophil Count	0.4	2.8	5.6	2.4	2.2	0.6	0.6
Blood Platelet Count	0.4	4.4	8.9	-0.6	-1.8	-3.0	2.2
Heel T-Score	0.4	3.3	5.3	-1.0	-1.8	-2.0	2.3
Hypothyroidism (self reported)	0.4	0.9	2.7	0.4	1.6	-0.6	0.5
Supplements: Zinc	0.4	0.4	1.5	-0.4	-0.0	-0.1	1.2
Maternal smoking around birth	0.4	0.5	1.2	0.1	0.9	-0.4	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.0	-0.9	-1.4	-1.1	0.2
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.5	0.3	-0.6	-0.3	1.6
Chronic bronchitis/emphysema (father)	0.4	0.5	1.3	0.5	-1.1	0.2	-0.6
Trunk fat mass	0.4	1.8	3.0	-1.0	-1.6	-0.7	1.7
Mouth/teeth dental problems	0.4	0.6	2.1	0.4	1.5	-0.0	0.0
Weight	0.4	2.2	3.5	1.3	1.9	-0.4	1.9
Pulse rate	0.4	0.7	2.4	0.5	0.0	0.2	1.5
Noisy workplace	0.4	0.4	1.1	-1.1	-0.5	-0.5	-0.4
Mouth/teeth dental problems: Dentures	0.4	0.7	1.8	0.3	-0.9	1.3	0.0
Wheeze or whistling in the chest in last year	0.4	0.7	1.9	-0.4	-1.4	0.6	-0.7
Guilty feelings	0.4	0.6	1.2	0.0	-0.7	-0.9	1.1
Bipolar Disorder or Schizophrenia	0.3	0.7	2.2	0.8	0.1	0.0	1.5
Depressed Affect (Nagel 2018)	0.3	0.7	2.2	0.6	1.5	0.1	0.5
Crohns Disease (2017)	0.3	0.7	1.5	0.3	-1.2	0.9	-0.5
Irritable Bowel Disease (IBD)	0.3	0.7	1.8	0.1	-0.6	0.8	-1.4
Crohns Disease (2012)	0.3	0.5	1.4	-0.5	-1.2	-0.3	0.5
Ulcerative Colitis	0.3	0.4	1.7	-0.0	0.0	-0.3	-1.3
Sensitivity / hurt feelings	0.3	0.5	1.6	-0.1	-1.2	-0.4	0.5
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.8	0.7	0.6	0.1
Medication: Metformin	0.3	0.4	0.6	-0.7	-0.8	-0.2	0.7
Fed-up feelings	0.3	0.5	1.2	0.7	0.5	1.1	-0.3
Relative age voice broke	0.3	0.4	1.2	0.4	-1.1	0.6	0.1
Age when periods started (menarche)	0.3	0.7	1.6	-1.1	-1.3	-0.4	0.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.1	0.2	0.0	-0.4	-1.1
Waist circumference	0.3	1.2	3.5	-0.5	-0.9	-0.7	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	0.6	1.0	0.1	0.5
Impedance of arm (right)	0.3	1.4	3.6	-1.9	-0.9	-0.7	-0.9
Hip circumference	0.3	1.5	3.6	-0.6	-0.6	-1.2	1.9
Father’s age at death	0.3	0.3	0.7	-0.3	-0.8	-0.8	0.2
Worrier / anxious feelings	0.3	0.6	1.0	-1.0	0.7	-0.4	0.8
Number of live births	0.3	0.4	0.9	0.2	0.2	1.0	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.7	0.5	0.7	0.8	0.1
Breastfed as a baby	0.3	0.3	0.9	0.2	1.0	0.4	-0.4
Glaucoma (self-reported)	0.3	0.4	1.3	0.4	-1.2	-0.2	-0.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.5	0.7	-0.3	0.7	-0.6
Migraine (self-reported)	0.3	0.4	0.8	-0.9	-0.2	-0.7	0.5
Knee pain experienced in last month	0.3	0.4	1.1	-1.0	-0.4	0.1	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.0	0.6	0.2	1.0	0.1
High cholesterol (Self-reported)	0.3	0.5	2.0	-0.2	0.0	-0.3	1.4
Cholesterol lowering medication	0.3	0.5	1.2	1.1	-0.5	0.4	0.5
Neuroticism (Nagel 2018)	0.2	0.4	0.9	-0.3	0.3	-0.7	0.9
HDL Cholesterol	0.2	0.3	0.4	0.2	-0.6	-0.5	-0.6
Neuroticism	0.2	0.5	0.9	0.1	0.9	-0.6	0.8
Hair Pigment	0.2	6.3	18.2	2.4	4.3	1.1	-0.4
Relative age of first facial hair	0.2	0.5	1.3	0.5	-0.5	0.3	-1.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.9	-0.2	0.9	-0.2	0.4
Multivitamins +/- minerals	0.2	0.3	0.7	-0.5	0.0	-0.4	0.8
Hair/balding pattern: Pattern 2	0.2	0.3	0.3	-0.6	-0.5	0.5	0.5
Allergy	0.2	0.4	0.8	-0.7	0.1	-0.9	0.3
Impedance of arm (left)	0.2	1.1	3.2	-1.8	-0.9	-0.5	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.8	-0.4	0.6	-0.4	-0.9
Alcohol intake frequency.	0.2	0.5	0.9	-0.9	-0.5	-0.9	0.2
Overall health rating	0.2	0.4	1.2	-1.1	-0.3	-0.2	-0.6
Age at last live birth	0.2	0.2	0.7	-0.5	0.1	0.1	-0.8
Medication: Aspirin	0.2	0.3	0.8	-0.9	-0.1	-0.0	-0.6
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.2	0.6	-0.7	0.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	0.1	-0.9	0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	0.1	-0.3	0.8	-0.7
Medication: Aspirin	0.2	0.3	0.9	-0.9	-0.3	-0.3	-0.2
Medication: Gliclazide	0.2	0.3	0.6	0.8	0.6	0.2	0.1
Medication: Blood pressure	0.2	0.3	0.8	0.2	-0.5	0.9	-0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	0.3	0.4	0.9	0.3
Medication: Lisinopril	0.2	0.3	0.7	-0.8	-0.2	-0.3	0.4
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.6	-0.4	-0.5	-0.0
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	0.6	0.6	-0.3	0.1
Alcohol drinker status: Previous	0.2	0.3	0.9	-1.0	-0.2	-0.2	-0.3
Worry (Nagel 2018)	0.1	0.1	0.4	-0.7	0.2	-0.0	0.2
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.4	-0.5	-0.4	-0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.5	0.7	-0.4	0.3	0.0
Blood White Count	0.1	0.5	1.1	0.1	-0.8	0.6	1.0
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	-0.2	-0.5	0.2	0.7
Chronotype (morning person)	0.1	0.2	0.7	0.1	0.8	0.1	0.0
Tanning	0.1	1.5	3.5	1.6	1.9	0.4	0.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.0	0.1	-0.2	0.5
Current tobacco smoking	0.1	0.2	0.4	0.6	0.1	0.5	0.4
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.4	0.3	0.2	0.5
Diabetes (self-reported)	0.1	0.2	0.4	-0.1	0.7	0.4	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.5	-0.3	-0.5	0.0	0.7
Depression (self-reported)	0.1	0.1	0.4	0.7	0.3	0.0	-0.0
Prospective memory result	0.1	0.1	0.2	-0.5	-0.2	-0.4	0.3
Worry too long after embarrassment	0.1	0.2	0.3	0.5	-0.5	-0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.2	0.3	0.5	-0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.5	0.2	-0.1	0.7	-0.4
Medication: Allopurinol	0.1	0.2	0.3	0.5	0.3	0.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	0.3	-0.3	-0.3	-0.6
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.5	0.1	0.1	0.7
Smoking status: Current	0.1	0.2	0.3	0.5	-0.2	0.4	0.6
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.5	-0.7	-0.2	-0.3	0.0
Supplements: Calcium	0.1	0.1	0.2	0.2	0.2	0.2	-0.5
Impedance of whole body	0.1	0.6	1.5	-1.2	-0.9	-0.0	-0.3
Impedance of leg (right)	0.0	0.2	0.3	-0.6	-0.4	-0.4	0.1
Townsend deprivation index at recruitment	0.0	0.0	0.1	-0.3	-0.1	-0.0	0.1
Impedance of leg (left)	0.0	0.1	0.1	-0.3	-0.4	0.1	0.2
Nervous feelings	0.0	0.1	0.1	-0.1	0.2	-0.1	-0.4
Neuroticism score	0.0	0.1	0.2	-0.1	0.3	-0.3	0.4
Pulse rate, automated reading	0.0	0.1	0.2	0.5	0.3	0.4	0.1
Suffer from ‘nerves’	0.0	0.1	0.1	0.3	0.0	0.3	0.2
Chest pain or discomfort	0.0	0.1	0.2	0.2	0.1	-0.1	0.4
Pain experienced in last month	0.0	0.1	0.2	0.2	-0.1	0.4	0.1

Hub : Genes

C20orf199

Models

Trait associations