TWAS hub - DDX27

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0450	0.0170	0.00035	0.038	0.039	0.070	0.042	0.057	1.6e-05	1.5e-05	7.3e-09	6.9e-06	1.7e-07
2	GTEx	Brain Cerebellar Hemisphere	0.3030	0.1010	0.00260	0.073	NA	-0.006	NA	0.034	6.3e-03	NA	4.8e-01	NA	4.8e-02
3	GTEx	Breast Mammary Tissue	0.1150	0.0550	0.00700	0.017	NA	0.019	NA	0.019	4.5e-02	NA	3.5e-02	NA	3.7e-02
4	GTEx	Breast Mammary Tissue (Male)	0.0452	0.0651	0.28000	0.012	NA	0.036	NA	0.039	1.7e-01	NA	5.1e-02	NA	4.4e-02
5	TCGA	Thyroid Carcinoma	0.0750	0.0390	0.00014	0.047	0.039	0.035	NA	0.048	2.0e-05	9.3e-05	2.0e-04	NA	1.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	5
Verbal and Numeric Reasoning (VNR)	7.0	16.7	42.9	5.3	-1.4	3.2	6.5
Intelligence (Savage-Jansen 2018)	6.8	20.9	59.0	5.7	-1.6	3.3	7.7
Financial difficulties in last 2 years	6.7	9.0	21.6	4.7	-1.8	3.6	2.8
Frequency of tiredness / lethargy in last 2 weeks	6.1	9.9	20.0	3.7	-3.1	2.5	4.5
Schizophrenia vs Biploar Disorder	5.6	7.4	16.2	4.0	0.2	2.7	3.7
Ever depressed for a whole week	5.2	6.4	12.6	3.5	-2.5	1.0	3.6
Financial situation satisfaction	5.0	6.2	12.6	3.5	-1.0	2.6	3.3
Loneliness, isolation	4.8	6.6	21.7	2.7	-1.6	1.3	4.7
Comparative height size at age 10	4.6	25.2	91.0	2.4	-5.0	-2.2	9.5
Forced vital capacity (FVC)	4.2	16.0	58.1	3.0	-2.9	-2.1	7.6
Qualifications: O levels/GCSEs or equivalent	4.2	6.7	14.6	3.3	0.7	2.7	3.8
Frequency of depressed mood in last 2 weeks	4.1	5.7	15.4	2.9	-1.5	1.7	3.9
Ever unenthusiastic/disinterested for a whole week	4.1	5.0	11.8	2.7	-2.5	0.1	3.4
Mean time to correctly identify matches	4.1	7.7	19.5	3.7	-2.0	1.4	4.4
Hearing difficulty/problems with background noise	4.0	6.4	11.5	3.4	-2.3	1.9	3.4
Height	3.9	75.6	272.2	5.8	-7.8	-3.4	16.5
Happiness	3.8	4.7	10.8	2.9	-0.9	1.8	3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	5.0	9.5	3.0	-0.6	2.4	3.1
Forced vital capacity (FVC), Best measure	3.6	13.2	49.0	3.2	-2.1	-1.5	7.0
Standing height	3.4	33.8	133.5	3.3	-4.1	-2.8	11.6
Time employed in main current job	3.3	3.8	7.2	-2.7	1.3	-2.2	-2.3
Family relationship satisfaction	3.2	4.0	8.7	2.7	-0.6	1.8	2.9
Depression (Nagel 2018)	3.0	4.6	13.9	2.4	-0.8	1.6	3.7
Sitting height	2.9	20.9	85.2	3.4	-2.7	-0.7	9.2
Number of children fathered	2.9	3.3	8.3	-2.9	1.3	-1.3	-2.2
Average weekly beer plus cider intake	2.9	4.3	8.6	-2.4	-0.1	-2.6	-2.9
Reaction Time	2.8	5.3	12.5	3.2	-1.5	1.3	3.5
Hearing difficulty/problems: Yes	2.8	4.3	7.2	2.5	-2.0	2.7	2.0
Qualifications: None of the above	2.8	6.1	11.5	-3.4	1.8	-2.3	-3.2
Friendships satisfaction	2.8	3.5	8.8	2.6	0.1	1.4	3.0
Hearing aid user	2.8	3.2	5.8	2.4	-0.0	2.3	2.2
Forced expiratory volume in 1-second (FEV1)	2.6	8.8	29.0	1.6	-2.8	-2.1	5.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	3.9	12.5	3.5	-0.5	2.2	1.4
Medication: Paracetamol	2.5	3.8	10.2	-3.2	-0.3	-1.3	-2.7
Medication: Ibuprofen	2.4	2.9	6.0	-2.3	1.5	-1.0	-2.4
Heart disease (mother)	2.4	2.9	6.6	2.1	-1.4	1.3	2.6
Miserableness	2.3	4.1	6.8	2.6	-2.4	1.3	2.5
Trunk fat-free mass	2.2	12.4	41.5	1.7	-3.9	-1.6	6.4
Average weekly champagne plus white wine intake	2.2	3.0	7.0	0.2	2.3	1.6	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.6	22.8	1.8	-2.1	-1.6	4.8
Trunk predicted mass	2.1	12.1	40.6	1.7	-3.8	-1.5	6.4
Alzheimer’s Disease (in father)	2.0	2.1	5.7	1.7	-1.4	0.4	2.4
Major Depression (MDD)	2.0	2.4	5.1	2.3	-0.7	1.7	1.8
Taking other prescription medications	2.0	3.1	8.9	2.3	-1.1	3.0	-0.7
Fluid intelligence score	2.0	4.1	9.1	2.7	0.6	1.9	3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.7	5.9	2.4	-1.2	2.2	1.0
Bipolar Disorder (2018)	1.9	2.9	5.1	-2.2	-1.8	-1.3	-2.3
Schizophrenia (2014)	1.9	4.1	8.9	3.0	-0.3	1.9	2.8
Allergy or Eczema	1.9	4.9	10.8	2.9	0.1	3.3	2.3
High blood pressure (mother)	1.9	2.7	4.8	-2.0	2.1	0.0	-2.2
Medication: Paracetamol	1.9	3.1	7.5	-2.7	-0.2	-1.3	-2.5
Bipolar Disorder (2011)	1.7	1.6	4.9	-1.7	0.5	0.0	-2.2
Qualifications: A levels/AS levels or equivalent	1.7	3.7	14.8	1.8	-0.3	0.6	3.8
Asthma	1.7	3.4	8.4	2.9	-1.6	2.0	1.5
Pulse wave Arterial Stiffness index	1.7	2.0	3.9	1.7	-2.0	0.7	1.5
Ever highly irritable/argumentative for 2 days	1.7	2.0	9.4	0.7	-0.6	-0.0	3.1
Whole body fat-free mass	1.7	9.9	30.6	1.7	-3.9	-1.0	5.5
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	9.5	-1.3	-1.4	-3.1	0.4
Whole body water mass	1.7	9.7	29.6	1.7	-3.9	-1.0	5.4
Mother’s age at death	1.7	2.1	8.4	-0.1	2.9	1.4	-0.2
Leg fat percentage (left)	1.7	6.0	20.7	-2.8	0.7	1.0	-4.6
Schizophrenia (2018)	1.6	3.4	6.8	2.6	-0.6	1.8	2.5
Hand grip strength (right)	1.6	4.5	16.0	0.1	-0.9	-2.3	4.0
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.2	-1.6	1.4	-0.7	-2.3
Leg fat percentage (right)	1.6	5.7	20.2	-2.6	0.7	0.9	-4.5
Arm fat-free mass (right)	1.6	8.0	25.6	1.6	-3.3	-0.8	5.1
Fractured/broken bones in last 5 years	1.6	2.0	5.4	-2.3	1.1	-1.2	-1.5
Myopia	1.6	2.4	7.6	-1.2	2.8	0.5	-1.6
Respiratory disease	1.5	3.4	5.4	2.3	-2.2	1.9	1.7
Arm fat percentage (right)	1.5	6.0	23.2	-2.0	-0.1	1.8	-4.8
Medication: Seretide 50 evohaler	1.5	1.7	5.5	1.7	-0.6	2.3	-0.0
Arm predicted mass (right)	1.5	7.6	27.1	1.5	-2.8	-0.7	5.2
Arm fat percentage (left)	1.5	5.8	21.5	-1.5	-0.4	2.3	-4.6
Long-standing illness, disability or infirmity	1.5	2.3	4.4	1.6	-2.1	1.4	1.5
Asthma (self-reported)	1.5	3.0	6.9	2.6	-1.6	1.9	1.3
High cholesterol (Self-reported)	1.5	2.6	5.9	2.4	-1.8	1.8	0.9
Heart disease (siblings)	1.5	1.8	3.1	1.8	0.9	1.7	1.6
Body Mass Index (BMI) (2010)	1.4	1.9	3.8	-1.7	2.0	-0.5	-1.6
Medication: Simvastatin	1.4	2.1	4.0	1.6	-2.0	2.0	-0.4
Worrier / anxious feelings	1.4	2.6	7.1	2.7	0.1	1.6	1.8
Lung cancer (father)	1.4	1.6	4.4	1.1	0.8	2.1	1.3
Length of working week for main job	1.4	1.5	3.2	1.0	-1.4	1.8	-1.2
Leg fat-free mass (right)	1.4	7.2	17.6	1.9	-3.9	0.2	4.2
Qualifications: nursing, teaching	1.4	2.1	7.3	1.5	0.7	0.7	2.7
Leg predicted mass (right)	1.4	7.4	18.0	1.9	-3.9	0.2	4.2
Basal metabolic rate	1.4	7.5	21.4	1.3	-3.8	-0.7	4.6
Blood Red Count	1.3	13.0	26.9	5.2	-2.8	3.4	4.3
Medication: Levothyroxine sodium	1.3	2.2	4.8	1.1	-2.2	-0.5	2.2
Alcohol usually taken with meals	1.3	2.1	5.8	0.7	2.0	2.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	3.9	2.0	-1.5	1.3	1.5
Had other major operations	1.3	1.5	3.4	1.0	1.6	1.9	-0.8
Allergy	1.3	2.9	8.5	-2.2	0.5	-2.9	-0.9
Birth weight of first child	1.3	2.4	5.3	2.3	-1.3	0.1	2.3
Pulse wave peak to peak time	1.3	1.5	3.7	-1.5	1.9	-0.8	-0.9
Arm fat-free mass (left)	1.3	6.5	22.2	1.2	-2.9	-1.0	4.7
Arm predicted mass (left)	1.3	6.4	22.6	1.2	-2.7	-0.8	4.8
Rheumatoid Arthritis	1.2	1.7	6.4	-0.7	-1.0	-0.7	-2.5
Systolic Blood Pressure	1.2	6.1	14.0	-1.6	3.4	1.3	-3.7
Average weekly spirits intake	1.2	1.5	5.0	-1.4	-0.5	-2.2	0.5
Leg fat-free mass (left)	1.2	6.2	14.7	1.5	-3.8	-0.1	3.8
Leg predicted mass (left)	1.2	6.3	14.7	1.4	-3.8	-0.2	3.8
Headache pain in last month	1.2	2.0	8.0	0.7	-2.8	-0.1	1.3
Had major operations	1.2	1.3	5.5	0.0	2.4	1.1	-0.2
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.7	-1.6	0.8	-1.2	-1.4
Illnesses of siblings: Diabetes	1.2	1.5	6.1	0.9	-2.5	0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	10.8	0.2	-0.3	-1.3	3.3
Osteoporosis (self-reported)	1.2	1.5	5.5	-1.1	-0.1	-0.9	-2.4
Medication: Gliclazide	1.2	1.3	2.9	-1.7	-1.2	-1.5	-0.1
Wears glasses or contact lenses	1.2	1.4	2.7	-1.6	-0.4	-1.5	-1.5
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.7	0.8	1.0	1.9	1.2
Depressed Affect (Nagel 2018)	1.1	2.3	4.8	2.2	-1.0	1.2	2.1
Ovarian Cancer	1.1	1.4	3.5	0.7	-1.7	-0.6	1.9
Hypothyroidism (self reported)	1.1	2.6	4.6	2.0	-1.6	1.4	2.1
Lung FVC	1.1	5.7	22.7	1.9	-0.7	-1.3	4.8
Hand grip strength (left)	1.1	2.8	9.1	0.4	-0.2	-2.2	3.0
Hayfever, allergic rhinitis or eczema	1.1	2.4	8.3	1.8	0.6	2.9	0.6
High blood pressure (siblings)	1.1	1.6	4.3	1.9	-0.3	2.1	-0.5
Body fat percentage	1.1	4.5	15.6	-1.9	0.2	1.7	-3.9
Suffer from ‘nerves’	1.1	1.8	6.7	2.6	-0.7	1.0	0.8
Mineral and other dietary supplements	1.1	1.5	3.3	-1.3	0.1	-1.6	-1.8
Eye problems/disorders: Glaucoma	1.1	1.2	4.4	-0.9	0.1	-1.1	-2.1
Cholesterol lowering medication	1.1	1.6	3.9	1.7	-2.0	1.2	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	6.0	0.4	-2.4	-0.7	0.6
HDL Cholesterol	1.0	1.7	4.7	-2.2	-0.1	-1.3	-1.5
BMI	1.0	5.9	22.2	-1.0	-0.1	2.5	-4.7
Supplements: Zinc	1.0	1.0	2.1	1.4	0.8	1.4	0.7
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	3.2	-1.3	-0.4	-1.8	-0.6
Illnesses of siblings	1.0	1.3	3.2	-1.7	0.3	-1.8	-0.6
Mouth/teeth dental problems: Dentures	1.0	1.7	6.7	1.4	0.2	2.6	0.2
Prospective memory result	1.0	1.2	2.4	-1.5	1.0	-1.5	-0.5
Peak expiratory flow (PEF)	1.0	2.3	5.2	0.2	-1.8	-1.8	2.3
Number of full brothers	1.0	1.2	3.8	0.6	1.4	2.0	0.2
Medication for pain relief, constipation, heartburn	1.0	1.7	4.7	1.1	-1.6	-0.2	2.2
Smoking status: Previous	1.0	1.5	6.5	0.3	0.6	-0.6	2.6
Number of self-reported non-cancer illnesses	1.0	1.7	4.0	1.0	-2.0	1.8	-0.7
Risk taking	1.0	1.4	3.7	-1.9	-0.3	-1.7	-0.6
Number of treatments/medications taken	0.9	1.6	5.6	1.1	-0.6	2.4	-0.9
Average weekly fortified wine intake	0.9	1.1	3.5	1.3	-0.2	-0.1	1.9
Body mass index (BMI)	0.9	3.7	12.4	-1.3	-0.7	2.0	-3.5
Depression (self-reported)	0.9	1.1	2.6	1.6	-0.7	1.3	0.7
Tense / ‘highly strung’	0.9	1.4	3.7	1.8	-0.1	-0.4	1.9
Hair/balding pattern: Pattern 4	0.9	2.1	6.2	-2.5	-0.6	-1.8	-0.8
Loud music exposure frequency	0.9	0.9	1.9	-0.8	-1.4	-1.4	-0.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	5.0	1.1	-2.2	-0.2	1.6
Birth weight	0.9	2.0	6.4	1.5	1.3	-0.1	2.5
Qualifications: College or University degree	0.9	2.7	9.3	1.7	-1.0	0.5	3.0
Ever had bowel cancer screening	0.9	1.1	2.6	0.8	-0.1	1.6	1.5
Diastolic blood pressure, automated reading	0.9	2.7	6.3	-2.5	-0.4	-0.8	-2.5
Neuroticism (2016)	0.8	1.1	2.1	1.2	0.0	1.4	1.4
Vitamin and mineral supplements	0.8	1.1	3.0	-0.7	1.7	0.1	-1.4
Trunk fat percentage	0.8	3.0	9.7	-1.5	-0.0	1.8	-3.1
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.2	1.2	-0.0	0.9	1.5
Supplements: Glucosamine	0.8	1.0	3.0	1.0	0.1	1.7	1.1
Past tobacco smoking	0.8	1.5	5.4	0.6	-0.9	1.1	-2.3
Had menopause	0.8	1.1	3.0	1.1	0.4	0.9	1.7
Hair/balding pattern: Pattern 3	0.8	1.2	2.5	1.4	-0.9	1.0	1.6
Blood clot in the leg (DVT)	0.8	1.0	4.5	0.3	-2.1	-0.5	0.4
Chronic bronchitis/emphysema (mother)	0.8	1.0	2.1	1.3	1.0	1.5	-0.4
Illnesses of father: High blood pressure	0.8	1.0	3.0	-1.7	-0.9	-0.8	-0.8
Irritability	0.8	1.4	3.9	1.4	-1.0	0.4	2.0
Supplements: Calcium	0.8	0.9	2.3	1.5	-0.4	1.2	0.9
Basal cell carcinoma (self-reported)	0.8	0.9	3.0	1.1	-1.7	0.1	0.7
Worry (Nagel 2018)	0.7	1.6	5.3	2.3	0.9	0.9	0.9
Prostate Cancer	0.7	1.0	2.6	-1.3	-0.9	-0.3	-1.6
Cardiovascular Disease	0.7	2.5	7.7	1.9	-0.6	2.8	-0.9
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	1.2	0.6	1.2	0.9
Impedance of leg (right)	0.7	3.3	8.6	-1.7	2.9	-2.0	-0.9
High blood pressure	0.7	1.8	5.6	0.7	0.9	2.4	-1.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.3	-1.5	0.1	-0.1	-1.4
Impedance of leg (left)	0.7	3.4	8.8	-1.9	3.0	-1.9	-0.9
Number of incorrect matches in round	0.7	1.2	4.4	-0.9	0.6	0.8	-2.1
Exposure to tobacco smoke at home	0.7	0.8	2.2	-0.7	-0.1	-1.5	-1.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.7	-1.3	-0.4	-0.9	-1.3
Age at first live birth	0.7	1.3	3.8	-1.1	1.9	-0.5	-1.2
Health satisfaction	0.7	0.9	3.4	0.7	0.9	1.9	-0.3
Emphysema/chronic bronchitis	0.7	0.7	3.6	-0.2	-1.9	0.1	-0.2
Number of full sisters	0.7	0.8	3.3	0.4	0.8	1.8	0.0
Age at last live birth	0.7	1.0	3.1	-1.1	1.8	-0.6	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.1	-0.1	0.6	1.4	-1.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.4	-1.5	0.4	-1.0	-1.0
Hypertension (Self-reported)	0.7	1.9	6.8	0.8	0.8	2.6	-1.2
Medication for cholesterol	0.7	1.0	2.6	-1.0	0.9	-1.6	0.8
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.7	1.2	0.7	1.3	0.9
Ever smoked	0.7	1.2	4.3	-0.3	1.2	-0.5	2.1
Commuting to job workplace: Cycle	0.7	0.8	1.9	1.4	-0.1	1.0	1.2
Age at First Birth	0.6	0.9	2.7	0.9	0.3	1.7	0.8
Coronary Artery Disease (CAD)	0.6	0.7	1.9	0.0	-1.0	0.8	-1.4
Blood Eosinophil Count	0.6	4.3	8.1	2.9	-0.1	2.4	2.8
Lung FEV1/FVC ratio	0.6	3.2	8.1	-2.8	-0.3	-0.7	-2.7
Neuroticism	0.6	1.6	4.7	2.2	-0.4	0.4	1.6
Medication for hormone replacement therapy	0.6	0.6	2.0	1.0	-0.3	1.4	0.0
Diabetes (mother)	0.6	0.8	2.5	-0.4	-1.0	-0.5	-1.6
Pack years adult smoking proportion	0.6	0.9	4.4	0.5	-2.1	-0.2	-0.3
Maternal smoking around birth	0.6	0.9	2.1	0.7	-1.4	0.5	1.2
Heart attack	0.6	0.8	2.1	-0.4	1.4	0.7	-1.1
Medication: Ramipril	0.6	0.8	2.9	-1.0	0.0	-0.3	-1.7
Father’s age at death	0.6	0.8	2.2	-0.9	1.5	-0.6	-0.9
Medication: Ventolin 100micrograms inhaler	0.6	0.7	3.1	0.1	-1.8	-0.6	-0.4
Medication: Blood pressure	0.6	1.1	3.7	0.3	0.4	1.2	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.3	0.8	-1.0	1.1	0.9
Alcohol intake frequency.	0.6	1.4	3.3	1.6	-1.8	1.0	-0.2
Leg pain on walking	0.6	0.8	1.5	1.2	0.1	1.0	1.1
Supplements: Vitamin C	0.6	0.8	2.8	0.5	0.3	0.8	1.7
Commuting to job workplace: Public transport	0.6	0.7	2.7	0.9	-0.3	0.2	1.7
Alcohol drinker status: Never	0.6	0.8	1.9	1.4	0.3	1.2	0.6
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.2	-0.6	-0.3	-2.0	1.8
Neuroticism (Nagel 2018)	0.5	1.2	3.7	1.9	0.3	1.1	1.0
Fasting Glucose	0.5	0.6	2.1	-0.8	0.6	0.3	-1.5
Primary Biliary Cirrhosis	0.5	0.7	1.8	-0.8	1.3	-0.8	-0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.5	2.2	0.4	-1.5	0.3	-0.4
Smoking Status	0.5	1.3	5.1	-0.3	-0.3	-1.0	2.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.2	0.8	-0.9	0.7	1.1
Medication: Co-codamol	0.5	0.6	1.3	0.5	-0.0	1.1	1.1
Relative age voice broke	0.5	0.7	1.6	1.0	1.3	0.5	-0.9
Weight	0.5	2.2	6.9	0.4	-2.6	0.6	1.9
Falls in the last year	0.5	0.6	1.8	-0.0	1.4	0.7	0.9
Medication: Cholesterol lowering	0.5	0.7	1.8	1.0	-0.9	1.4	0.0
Arm fat mass (right)	0.5	1.9	4.8	-0.9	-1.4	1.4	-2.2
Pulse wave reflection index	0.5	0.6	1.0	0.9	-0.6	0.9	1.0
Medication: Amlodipine	0.5	0.7	2.0	-0.2	1.1	1.4	0.1
Exposure to tobacco smoke outside home	0.5	0.6	1.6	0.3	-1.3	0.3	-1.2
Shortness of breath walking on level ground	0.5	0.6	2.2	-0.3	-0.8	-0.2	-1.5
Neck or shoulder pain in last month	0.5	0.7	1.7	0.9	-0.3	0.9	1.3
Medication: Omeprazole	0.5	0.6	2.5	-1.6	-0.3	-0.3	-0.8
Knee pain experienced in last month	0.5	0.7	2.5	-1.6	0.1	-0.9	-0.5
Mood swings	0.5	0.9	2.3	-0.6	-0.9	-0.9	-1.5
Back pain experienced in last month	0.5	0.8	2.1	-0.6	-0.1	-1.5	1.2
Smoking status: Current	0.5	0.7	2.5	-1.6	-0.1	-0.9	-0.5
Arm fat mass (left)	0.5	1.9	4.9	-0.9	-1.0	1.7	-2.2
Ever taken oral contraceptive pill	0.5	0.5	1.4	-0.6	0.4	-1.0	1.2
HbA1C	0.4	0.5	1.7	0.1	-1.3	-0.7	0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.6	-1.3	-1.1	-1.0	-0.6
Systolic blood pressure, automated reading	0.4	1.2	3.6	-1.0	0.4	1.1	-1.9
Medication: Metformin	0.4	0.6	1.2	-1.0	-0.4	-1.1	-0.7
Age when periods started (menarche)	0.4	0.9	3.7	0.1	1.9	-0.0	-0.9
Medication: Atenolol	0.4	0.6	2.5	-0.2	-0.3	0.4	-1.6
Chronic bronchitis/emphysema (father)	0.4	0.5	2.3	-0.3	-0.0	-0.0	-1.5
Glaucoma (self-reported)	0.4	0.4	1.9	-0.3	0.4	-0.3	-1.4
Comparative body size at age 10	0.4	1.1	3.0	0.1	-0.9	1.3	-1.7
Migraine (self-reported)	0.4	0.4	1.4	-0.5	-1.2	-0.7	-0.3
Leg fat mass (right)	0.4	1.5	4.2	-1.3	-0.6	1.0	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.0	-1.0	0.6	0.3	-1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-0.6	1.0	-0.3	-0.9
Eye problems/disorders: Cataract	0.4	0.4	1.0	-0.9	0.5	0.2	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.9	1.1	-0.7	-0.2	1.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.8	0.3	0.4	1.3	0.1
Pain type(s) experienced in last month: Hip pain	0.4	0.4	1.1	0.6	-0.8	0.3	-1.0
Number of operations (self-reported)	0.4	0.6	1.3	-0.5	1.1	0.8	-0.8
Unable to work because of sickness or disability	0.4	0.5	1.0	0.7	-1.0	0.5	1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.6	-0.3	1.3	0.7	-0.7
Pack years of smoking	0.4	0.6	2.7	0.5	-1.7	-0.1	0.1
Leg fat mass (left)	0.4	1.7	4.7	-1.5	-0.8	0.8	-2.2
Bipolar Disorder or Schizophrenia	0.3	0.7	2.5	0.7	-1.6	0.6	0.5
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	0.5	-0.4	0.9	1.0
Ulcerative Colitis (UC)	0.3	0.5	2.2	0.4	-1.5	0.1	0.4
Breast Cancer	0.3	0.8	3.3	0.4	1.8	-0.1	0.7
LDL Cholesterol	0.3	0.4	1.8	-0.6	-0.1	-1.3	0.2
Ulcerative Colitis	0.3	0.5	2.5	-0.2	-1.6	0.1	-0.1
Blood White Count	0.3	2.5	7.9	2.0	0.3	2.8	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.0	1.0	0.3	0.9	-0.2
Angina	0.3	0.4	0.8	-0.6	-0.8	0.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	1.2	1.1	0.2	-1.0
Qualifications: CSEs or equivalent	0.3	0.4	1.7	-0.5	-0.4	-0.2	-1.3
Serious illness, injury or assault to yourself	0.3	0.4	1.7	0.2	0.3	0.5	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.5	1.2	1.1	0.2	-0.9
Pain all over the body in last month	0.3	0.3	1.0	1.0	-0.0	0.8	0.1
Neuroticism score	0.3	0.7	2.6	1.6	-0.4	0.3	0.8
Hip circumference	0.3	1.4	3.6	0.7	-1.7	1.9	0.0
Alcohol intake versus 10 years previously	0.3	0.4	1.5	0.5	-0.4	1.2	-0.1
Noisy workplace	0.3	0.3	1.2	0.7	-1.1	-0.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	-0.2	0.3	-1.0	1.1
Worry too long after embarrassment	0.3	0.6	1.8	-0.7	-0.0	-1.3	-0.8
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	-0.3	-1.3	0.5	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.8	-1.4	-0.3	-0.2	-0.2
Whole body fat mass	0.3	1.4	2.9	-1.1	-1.1	1.2	-1.7
Commuting to job workplace: Walk	0.3	0.3	0.8	0.7	-0.3	0.5	0.9
Medication: Bendroflumethiazide	0.3	0.4	1.5	0.4	-0.0	1.2	-0.5
Impedance of whole body	0.3	1.4	5.0	-0.8	2.2	-0.6	-1.1
Lupus	0.2	0.3	0.6	-0.4	0.1	-0.8	0.7
Blood Platelet Count	0.2	2.9	8.4	-0.6	-2.9	-1.6	-1.7
Waist Hip Ratio (WHR)	0.2	1.1	4.8	-0.4	-0.8	0.0	2.2
Chronotype (morning person)	0.2	0.4	0.8	0.5	-0.9	-0.5	0.7
Tanning	0.2	2.7	9.4	1.0	-3.1	-0.0	1.8
Sensitivity / hurt feelings	0.2	0.4	0.8	0.9	0.5	0.7	-0.6
Diabetes (father)	0.2	0.3	1.0	-0.3	0.4	-0.1	-1.0
Current tobacco smoking	0.2	0.2	1.0	-1.0	-0.1	-0.5	-0.1
Trunk fat mass	0.2	1.0	1.9	-0.9	-1.0	1.4	-1.1
Waist circumference	0.2	0.9	3.6	-0.0	-0.8	1.9	-0.2
Nervous feelings	0.2	0.3	0.8	0.8	0.9	-0.4	0.1
Mouth/teeth dental problems	0.2	0.3	1.2	0.7	0.3	0.1	1.1
Diabetes (self-reported)	0.2	0.3	0.8	0.1	-0.7	0.2	0.9
Pulse rate	0.2	0.4	1.1	0.4	-0.8	-1.0	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.5	-0.2	-0.6	-0.7	0.6
Illnesses of mother	0.2	0.2	0.6	0.4	-0.5	-0.8	0.3
Breastfed as a baby	0.2	0.2	1.0	0.1	0.1	-0.4	1.0
Gout (self-reported)	0.2	0.3	1.0	-0.3	0.3	-0.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.9	-0.9	0.1	-0.2	-0.5
Angina (self-reported)	0.2	0.3	0.6	-0.6	-0.8	0.0	-0.8
Medication: Allopurinol	0.2	0.2	0.5	0.5	-0.7	0.3	0.6
Overall health rating	0.2	0.4	1.5	0.4	-0.7	1.2	0.0
Chest pain or discomfort	0.2	0.3	1.4	0.3	-1.2	0.2	0.3
Average weekly red wine intake	0.2	0.3	0.8	0.1	0.9	0.8	0.2
Diabetes diagnosed by doctor	0.2	0.3	0.8	-0.6	-0.9	-0.4	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	0.3	0.9	0.3	-0.2
Breast cancer (self-reported)	0.2	0.2	0.5	0.1	0.6	0.3	0.7
Osteoarthritis (self-reported)	0.2	0.2	0.8	-0.1	0.4	0.5	-0.9
Medication: Blood pressure	0.2	0.5	1.8	0.3	-0.5	1.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.5	-0.2	0.7	-0.4
Pain experienced in last month	0.2	0.4	1.3	0.8	0.4	1.1	0.2
Alcohol drinker status: Previous	0.2	0.2	0.5	0.5	-0.3	0.7	-0.1
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.4	0.4	0.4	-0.0
Crohns Disease (2017)	0.1	0.2	0.7	0.0	0.3	-0.6	-0.9
Irritable Bowel Disease (IBD)	0.1	0.2	0.8	0.1	-0.9	-0.4	-0.5
Crohns Disease (2012)	0.1	0.2	0.4	-0.2	0.0	-0.6	-0.7
Mean Putamen Volume	0.1	0.1	0.4	-0.0	-0.6	0.2	-0.4
Heel T-Score	0.1	0.9	1.9	-0.3	0.9	-1.4	-1.4
Hair Pigment	0.1	4.2	14.0	0.2	-2.3	-1.1	3.7
Relative age of first facial hair	0.1	0.2	0.6	0.8	0.3	-0.0	-0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.7	-0.1	-0.8	-0.2	-0.3
Severe depression (siblings)	0.1	0.1	0.1	0.2	-0.4	0.2	-0.4
Fed-up feelings	0.1	0.2	0.3	0.1	0.5	0.6	0.5
Multivitamins +/- minerals	0.1	0.1	0.2	-0.1	-0.4	0.2	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.3	0.4	0.1	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.3	0.5	-0.4	0.6	0.2
Impedance of arm (right)	0.1	0.5	1.3	-0.6	0.9	-0.3	-1.1
Medication: Lansoprazole	0.1	0.1	0.4	-0.4	-0.3	-0.7	-0.1
Impedance of arm (left)	0.1	0.3	0.6	-0.0	0.8	0.4	-0.8
Eye problems/disorders: None of the above	0.1	0.2	0.5	0.0	0.5	0.3	0.7
Pulse rate, automated reading	0.1	0.4	2.0	-0.4	0.2	-1.4	0.2
Medication: Aspirin	0.1	0.1	0.4	0.3	-0.1	0.6	0.0
Illnesses of father: Heart disease	0.1	0.2	0.5	-0.6	-0.2	-0.7	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	-0.1	0.6	-0.1	0.6
Medication: Aspirin	0.1	0.1	0.3	0.1	-0.6	0.3	-0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.0	0.7	-0.1	0.5
Guilty feelings	0.1	0.1	0.4	-0.3	0.2	-0.2	-0.7
Medication: Lisinopril	0.1	0.1	0.3	-0.1	0.2	0.5	-0.3
Medication: Atorvastatin	0.1	0.1	0.2	0.5	-0.3	-0.2	-0.1
Age started oral contraceptive pill	0.1	0.2	0.7	-0.2	0.8	0.1	0.4
Triglycerides	0.0	0.0	0.1	-0.0	0.2	0.1	-0.3
Townsend deprivation index at recruitment	0.0	0.0	0.1	-0.1	-0.4	0.3	0.1
Stomach or abdominal pain in last month	0.0	0.1	0.2	0.0	-0.0	0.4	0.4
Number of live births	0.0	0.1	0.2	-0.3	-0.1	-0.5	0.1

Hub : Genes

DDX27

Models

Trait associations