Hub : Genes

DDX27

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0450 0.0170 0.00035 0.038 0.039 0.070 0.042 0.057 1.6e-05 1.5e-05 7.3e-09 6.9e-06 1.7e-07
2 GTEx Brain Cerebellar Hemisphere 0.3030 0.1010 0.00260 0.073 NA -0.006 NA 0.034 6.3e-03 NA 4.8e-01 NA 4.8e-02
3 GTEx Breast Mammary Tissue 0.1150 0.0550 0.00700 0.017 NA 0.019 NA 0.019 4.5e-02 NA 3.5e-02 NA 3.7e-02
4 GTEx Breast Mammary Tissue (Male) 0.0452 0.0651 0.28000 0.012 NA 0.036 NA 0.039 1.7e-01 NA 5.1e-02 NA 4.4e-02
5 TCGA Thyroid Carcinoma 0.0750 0.0390 0.00014 0.047 0.039 0.035 NA 0.048 2.0e-05 9.3e-05 2.0e-04 NA 1.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.9 2.9 5.1 -2.2 -1.8 -1.3 0.0 -2.3
Bipolar Disorder or Schizophrenia 0.3 0.7 2.5 0.7 -1.6 0.6 0.0 0.5
Depressed Affect (Nagel 2018) 1.1 2.3 4.8 2.2 -1.0 1.2 0.0 2.1
Depression (Nagel 2018) 3.0 4.6 13.9 2.4 -0.8 1.6 0.0 3.7
Intelligence (Savage-Jansen 2018) 6.8 20.9 59.0 5.7 -1.6 3.3 0.0 7.7
Neuroticism (Nagel 2018) 0.5 1.2 3.7 1.9 0.3 1.1 0.0 1.0
Schizophrenia (2018) 1.6 3.4 6.8 2.6 -0.6 1.8 0.0 2.5
Schizophrenia vs Biploar Disorder 5.6 7.4 16.2 4.0 0.2 2.7 0.0 3.7
Worry (Nagel 2018) 0.7 1.6 5.3 2.3 0.9 0.9 0.0 0.9
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 -0.4 0.4 0.4 0.0 -0.0
Alzheimer’s Disease (in father) 2.0 2.1 5.7 1.7 -1.4 0.4 0.0 2.4
Alzheimer’s Disease (including proxy) 0.3 0.4 0.9 0.5 -0.4 0.9 0.0 1.0
Crohns Disease (2017) 0.1 0.2 0.7 0.0 0.3 -0.6 0.0 -0.9
Irritable Bowel Disease (IBD) 0.1 0.2 0.8 0.1 -0.9 -0.4 0.0 -0.5
Ulcerative Colitis (UC) 0.3 0.5 2.2 0.4 -1.5 0.1 0.0 0.4
Major Depression (MDD) 2.0 2.4 5.1 2.3 -0.7 1.7 0.0 1.8
Reaction Time 2.8 5.3 12.5 3.2 -1.5 1.3 0.0 3.5
Verbal and Numeric Reasoning (VNR) 7.0 16.7 42.9 5.3 -1.4 3.2 0.0 6.5
Breast Cancer 0.3 0.8 3.3 0.4 1.8 -0.1 0.0 0.7
Ovarian Cancer 1.1 1.4 3.5 0.7 -1.7 -0.6 0.0 1.9
Prostate Cancer 0.7 1.0 2.6 -1.3 -0.9 -0.3 0.0 -1.6
Age at First Birth 0.6 0.9 2.7 0.9 0.3 1.7 0.0 0.8
Bipolar Disorder (2011) 1.7 1.6 4.9 -1.7 0.5 0.0 0.0 -2.2
Body Mass Index (BMI) (2010) 1.4 1.9 3.8 -1.7 2.0 -0.5 0.0 -1.6
Coronary Artery Disease (CAD) 0.6 0.7 1.9 0.0 -1.0 0.8 0.0 -1.4
Crohns Disease (2012) 0.1 0.2 0.4 -0.2 0.0 -0.6 0.0 -0.7
Mean Putamen Volume 0.1 0.1 0.4 -0.0 -0.6 0.2 0.0 -0.4
Fasting Glucose 0.5 0.6 2.1 -0.8 0.6 0.3 0.0 -1.5
HbA1C 0.4 0.5 1.7 0.1 -1.3 -0.7 0.0 0.5
HDL Cholesterol 1.0 1.7 4.7 -2.2 -0.1 -1.3 0.0 -1.5
LDL Cholesterol 0.3 0.4 1.8 -0.6 -0.1 -1.3 0.0 0.2
Lupus 0.2 0.3 0.6 -0.4 0.1 -0.8 0.0 0.7
Neuroticism (2016) 0.8 1.1 2.1 1.2 0.0 1.4 0.0 1.4
Primary Biliary Cirrhosis 0.5 0.7 1.8 -0.8 1.3 -0.8 0.0 -0.6
Rheumatoid Arthritis 1.2 1.7 6.4 -0.7 -1.0 -0.7 0.0 -2.5
Schizophrenia (2014) 1.9 4.1 8.9 3.0 -0.3 1.9 0.0 2.8
Triglycerides 0.0 0.0 0.1 -0.0 0.2 0.1 0.0 -0.3
Type 2 Diabetes (T2D) (2012) 0.5 0.5 2.2 0.4 -1.5 0.3 0.0 -0.4
Ulcerative Colitis 0.3 0.5 2.5 -0.2 -1.6 0.1 0.0 -0.1
Blood Eosinophil Count 0.6 4.3 8.1 2.9 -0.1 2.4 0.0 2.8
Blood Platelet Count 0.2 2.9 8.4 -0.6 -2.9 -1.6 0.0 -1.7
Blood Red Count 1.3 13.0 26.9 5.2 -2.8 3.4 0.0 4.3
Blood White Count 0.3 2.5 7.9 2.0 0.3 2.8 0.0 0.4
Heel T-Score 0.1 0.9 1.9 -0.3 0.9 -1.4 0.0 -1.4
BMI 1.0 5.9 22.2 -1.0 -0.1 2.5 0.0 -4.7
Height 3.9 75.6 272.2 5.8 -7.8 -3.4 0.0 16.5
Waist Hip Ratio (WHR) 0.2 1.1 4.8 -0.4 -0.8 0.0 0.0 2.2
Systolic Blood Pressure 1.2 6.1 14.0 -1.6 3.4 1.3 0.0 -3.7
Smoking Status 0.5 1.3 5.1 -0.3 -0.3 -1.0 0.0 2.3
Allergy or Eczema 1.9 4.9 10.8 2.9 0.1 3.3 0.0 2.3
Cardiovascular Disease 0.7 2.5 7.7 1.9 -0.6 2.8 0.0 -0.9
Hypothyroidism (self reported) 1.1 2.6 4.6 2.0 -1.6 1.4 0.0 2.1
Respiratory disease 1.5 3.4 5.4 2.3 -2.2 1.9 0.0 1.7
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.6 -1.3 -1.1 -1.0 0.0 -0.6
Lung FEV1/FVC ratio 0.6 3.2 8.1 -2.8 -0.3 -0.7 0.0 -2.7
Lung FVC 1.1 5.7 22.7 1.9 -0.7 -1.3 0.0 4.8
Neuroticism 0.6 1.6 4.7 2.2 -0.4 0.4 0.0 1.6
Chronotype (morning person) 0.2 0.4 0.8 0.5 -0.9 -0.5 0.0 0.7
Hair Pigment 0.1 4.2 14.0 0.2 -2.3 -1.1 0.0 3.7
Tanning 0.2 2.7 9.4 1.0 -3.1 -0.0 0.0 1.8
Hand grip strength (left) 1.1 2.8 9.1 0.4 -0.2 -2.2 0.0 3.0
Number of treatments/medications taken 0.9 1.6 5.6 1.1 -0.6 2.4 0.0 -0.9
Average weekly spirits intake 1.2 1.5 5.0 -1.4 -0.5 -2.2 0.0 0.5
Sensitivity / hurt feelings 0.2 0.4 0.8 0.9 0.5 0.7 0.0 -0.6
Frequency of depressed mood in last 2 weeks 4.1 5.7 15.4 2.9 -1.5 1.7 0.0 3.9
Hearing difficulty/problems: Yes 2.8 4.3 7.2 2.5 -2.0 2.7 0.0 2.0
Relative age of first facial hair 0.1 0.2 0.6 0.8 0.3 -0.0 0.0 -0.4
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.2 0.8 -0.9 0.7 0.0 1.1
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.0 1.0 0.3 0.9 0.0 -0.2
Ever had hysterectomy (womb removed) 0.7 0.8 1.5 1.2 0.6 1.2 0.0 0.9
Systolic blood pressure, automated reading 0.4 1.2 3.6 -1.0 0.4 1.1 0.0 -1.9
Eye problems/disorders: Diabetes related eye disease 0.1 0.2 0.7 -0.1 -0.8 -0.2 0.0 -0.3
Angina 0.3 0.4 0.8 -0.6 -0.8 0.1 0.0 -0.9
Medication for hormone replacement therapy 0.6 0.6 2.0 1.0 -0.3 1.4 0.0 0.0
Vitamin and mineral supplements 0.8 1.1 3.0 -0.7 1.7 0.1 0.0 -1.4
Supplements: Zinc 1.0 1.0 2.1 1.4 0.8 1.4 0.0 0.7
Medication: Co-codamol 0.5 0.6 1.3 0.5 -0.0 1.1 0.0 1.1
Medication: Metformin 0.4 0.6 1.2 -1.0 -0.4 -1.1 0.0 -0.7
Diabetes (father) 0.2 0.3 1.0 -0.3 0.4 -0.1 0.0 -1.0
Diabetes (mother) 0.6 0.8 2.5 -0.4 -1.0 -0.5 0.0 -1.6
Severe depression (siblings) 0.1 0.1 0.1 0.2 -0.4 0.2 0.0 -0.4
Pack years adult smoking proportion 0.6 0.9 4.4 0.5 -2.1 -0.2 0.0 -0.3
Impedance of leg (right) 0.7 3.3 8.6 -1.7 2.9 -2.0 0.0 -0.9
Leg fat-free mass (left) 1.2 6.2 14.7 1.5 -3.8 -0.1 0.0 3.8
Trunk fat percentage 0.8 3.0 9.7 -1.5 -0.0 1.8 0.0 -3.1
Hand grip strength (right) 1.6 4.5 16.0 0.1 -0.9 -2.3 0.0 4.0
Townsend deprivation index at recruitment 0.0 0.0 0.1 -0.1 -0.4 0.3 0.0 0.1
Current tobacco smoking 0.2 0.2 1.0 -1.0 -0.1 -0.5 0.0 -0.1
Average weekly fortified wine intake 0.9 1.1 3.5 1.3 -0.2 -0.1 0.0 1.9
Maternal smoking around birth 0.6 0.9 2.1 0.7 -1.4 0.5 0.0 1.2
Fed-up feelings 0.1 0.2 0.3 0.1 0.5 0.6 0.0 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 3.7 5.0 9.5 3.0 -0.6 2.4 0.0 3.1
Relative age voice broke 0.5 0.7 1.6 1.0 1.3 0.5 0.0 -0.9
Taking other prescription medications 2.0 3.1 8.9 2.3 -1.1 3.0 0.0 -0.7
Age when periods started (menarche) 0.4 0.9 3.7 0.1 1.9 -0.0 0.0 -0.9
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.2 1.2 -0.0 0.9 0.0 1.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.3 1.2 1.1 0.2 0.0 -1.0
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 3.2 -1.3 -0.4 -1.8 0.0 -0.6
Qualifications: CSEs or equivalent 0.3 0.4 1.7 -0.5 -0.4 -0.2 0.0 -1.3
Serious illness, injury or assault to yourself 0.3 0.4 1.7 0.2 0.3 0.5 0.0 1.3
High blood pressure 0.7 1.8 5.6 0.7 0.9 2.4 0.0 -1.5
Hayfever, allergic rhinitis or eczema 1.1 2.4 8.3 1.8 0.6 2.9 0.0 0.6
Multivitamins +/- minerals 0.1 0.1 0.2 -0.1 -0.4 0.2 0.0 0.4
Stomach or abdominal pain in last month 0.0 0.1 0.2 0.0 -0.0 0.4 0.0 0.4
Supplements: Glucosamine 0.8 1.0 3.0 1.0 0.1 1.7 0.0 1.1
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 2.3 -1.5 0.1 -0.1 0.0 -1.4
Medication: Atenolol 0.4 0.6 2.5 -0.2 -0.3 0.4 0.0 -1.6
Medication: Levothyroxine sodium 1.3 2.2 4.8 1.1 -2.2 -0.5 0.0 2.2
Sitting height 2.9 20.9 85.2 3.4 -2.7 -0.7 0.0 9.2
Chronic bronchitis/emphysema (father) 0.4 0.5 2.3 -0.3 -0.0 -0.0 0.0 -1.5
High blood pressure (mother) 1.9 2.7 4.8 -2.0 2.1 0.0 0.0 -2.2
Body mass index (BMI) 0.9 3.7 12.4 -1.3 -0.7 2.0 0.0 -3.5
Impedance of leg (left) 0.7 3.4 8.8 -1.9 3.0 -1.9 0.0 -0.9
Leg predicted mass (left) 1.2 6.3 14.7 1.4 -3.8 -0.2 0.0 3.8
Trunk fat mass 0.2 1.0 1.9 -0.9 -1.0 1.4 0.0 -1.1
Waist circumference 0.2 0.9 3.6 -0.0 -0.8 1.9 0.0 -0.2
Number of incorrect matches in round 0.7 1.2 4.4 -0.9 0.6 0.8 0.0 -2.1
Past tobacco smoking 0.8 1.5 5.4 0.6 -0.9 1.1 0.0 -2.3
Alcohol usually taken with meals 1.3 2.1 5.8 0.7 2.0 2.4 0.0 0.2
Nervous feelings 0.2 0.3 0.8 0.8 0.9 -0.4 0.0 0.1
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 3.9 2.0 -1.5 1.3 0.0 1.5
Hearing difficulty/problems with background noise 4.0 6.4 11.5 3.4 -2.3 1.9 0.0 3.4
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.3 0.4 0.1 0.0 -0.4
Had menopause 0.8 1.1 3.0 1.1 0.4 0.9 0.0 1.7
Had other major operations 1.3 1.5 3.4 1.0 1.6 1.9 0.0 -0.8
Forced vital capacity (FVC) 4.2 16.0 58.1 3.0 -2.9 -2.1 0.0 7.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.5 1.2 1.1 0.2 0.0 -0.9
Ever unenthusiastic/disinterested for a whole week 4.1 5.0 11.8 2.7 -2.5 0.1 0.0 3.4
Qualifications: None of the above 2.8 6.1 11.5 -3.4 1.8 -2.3 0.0 -3.2
Financial difficulties in last 2 years 6.7 9.0 21.6 4.7 -1.8 3.6 0.0 2.8
Mouth/teeth dental problems 0.2 0.3 1.2 0.7 0.3 0.1 0.0 1.1
Heart attack 0.6 0.8 2.1 -0.4 1.4 0.7 0.0 -1.1
Allergy 1.3 2.9 8.5 -2.2 0.5 -2.9 0.0 -0.9
Pain all over the body in last month 0.3 0.3 1.0 1.0 -0.0 0.8 0.0 0.1
Diabetes (self-reported) 0.2 0.3 0.8 0.1 -0.7 0.2 0.0 0.9
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.3 0.5 -0.4 0.6 0.0 0.2
Medication: Ramipril 0.6 0.8 2.9 -1.0 0.0 -0.3 0.0 -1.7
Medication: Simvastatin 1.4 2.1 4.0 1.6 -2.0 2.0 0.0 -0.4
Fluid intelligence score 2.0 4.1 9.1 2.7 0.6 1.9 0.0 3.0
Illnesses of siblings 1.0 1.3 3.2 -1.7 0.3 -1.8 0.0 -0.6
Neuroticism score 0.3 0.7 2.6 1.6 -0.4 0.3 0.0 0.8
Weight 0.5 2.2 6.9 0.4 -2.6 0.6 0.0 1.9
Impedance of arm (right) 0.1 0.5 1.3 -0.6 0.9 -0.3 0.0 -1.1
Arm fat percentage (right) 1.5 6.0 23.2 -2.0 -0.1 1.8 0.0 -4.8
Trunk fat-free mass 2.2 12.4 41.5 1.7 -3.9 -1.6 0.0 6.4
Hip circumference 0.3 1.4 3.6 0.7 -1.7 1.9 0.0 0.0
Time employed in main current job 3.3 3.8 7.2 -2.7 1.3 -2.2 0.0 -2.3
Alcohol intake versus 10 years previously 0.3 0.4 1.5 0.5 -0.4 1.2 0.0 -0.1
Father’s age at death 0.6 0.8 2.2 -0.9 1.5 -0.6 0.0 -0.9
Worrier / anxious feelings 1.4 2.6 7.1 2.7 0.1 1.6 0.0 1.8
Frequency of tiredness / lethargy in last 2 weeks 6.1 9.9 20.0 3.7 -3.1 2.5 0.0 4.5
Falls in the last year 0.5 0.6 1.8 -0.0 1.4 0.7 0.0 0.9
Hair/balding pattern: Pattern 3 0.8 1.2 2.5 1.4 -0.9 1.0 0.0 1.6
Number of live births 0.0 0.1 0.2 -0.3 -0.1 -0.5 0.0 0.1
Forced expiratory volume in 1-second (FEV1) 2.6 8.8 29.0 1.6 -2.8 -2.1 0.0 5.4
Pulse rate 0.2 0.4 1.1 0.4 -0.8 -1.0 0.0 0.2
Happiness 3.8 4.7 10.8 2.9 -0.9 1.8 0.0 3.3
Noisy workplace 0.3 0.3 1.2 0.7 -1.1 -0.1 0.0 -0.1
Qualifications: A levels/AS levels or equivalent 1.7 3.7 14.8 1.8 -0.3 0.6 0.0 3.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.5 -0.2 -0.6 -0.7 0.0 0.6
Mouth/teeth dental problems: Dentures 1.0 1.7 6.7 1.4 0.2 2.6 0.0 0.2
Asthma 1.7 3.4 8.4 2.9 -1.6 2.0 0.0 1.5
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 5.2 -1.6 1.4 -0.7 0.0 -2.3
Medication: Cholesterol lowering 0.5 0.7 1.8 1.0 -0.9 1.4 0.0 0.0
Depression (self-reported) 0.9 1.1 2.6 1.6 -0.7 1.3 0.0 0.7
Medication: Lansoprazole 0.1 0.1 0.4 -0.4 -0.3 -0.7 0.0 -0.1
Prospective memory result 1.0 1.2 2.4 -1.5 1.0 -1.5 0.0 -0.5
Lung cancer (father) 1.4 1.6 4.4 1.1 0.8 2.1 0.0 1.3
Illnesses of mother 0.2 0.2 0.6 0.4 -0.5 -0.8 0.0 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.1 6.6 22.8 1.8 -2.1 -1.6 0.0 4.8
Pulse wave Arterial Stiffness index 1.7 2.0 3.9 1.7 -2.0 0.7 0.0 1.5
Impedance of arm (left) 0.1 0.3 0.6 -0.0 0.8 0.4 0.0 -0.8
Arm fat mass (right) 0.5 1.9 4.8 -0.9 -1.4 1.4 0.0 -2.2
Trunk predicted mass 2.1 12.1 40.6 1.7 -3.8 -1.5 0.0 6.4
Standing height 3.4 33.8 133.5 3.3 -4.1 -2.8 0.0 11.6
Length of working week for main job 1.4 1.5 3.2 1.0 -1.4 1.8 0.0 -1.2
Exposure to tobacco smoke at home 0.7 0.8 2.2 -0.7 -0.1 -1.5 0.0 -1.1
Breastfed as a baby 0.2 0.2 1.0 0.1 0.1 -0.4 0.0 1.0
Tense / ‘highly strung’ 0.9 1.4 3.7 1.8 -0.1 -0.4 0.0 1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 2.6 3.9 12.5 3.5 -0.5 2.2 0.0 1.4
Hair/balding pattern: Pattern 4 0.9 2.1 6.2 -2.5 -0.6 -1.8 0.0 -0.8
Birth weight of first child 1.3 2.4 5.3 2.3 -1.3 0.1 0.0 2.3
Peak expiratory flow (PEF) 1.0 2.3 5.2 0.2 -1.8 -1.8 0.0 2.3
Pulse wave reflection index 0.5 0.6 1.0 0.9 -0.6 0.9 0.0 1.0
Ever highly irritable/argumentative for 2 days 1.7 2.0 9.4 0.7 -0.6 -0.0 0.0 3.1
Loud music exposure frequency 0.9 0.9 1.9 -0.8 -1.4 -1.4 0.0 -0.5
Qualifications: O levels/GCSEs or equivalent 4.2 6.7 14.6 3.3 0.7 2.7 0.0 3.8
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.7 -1.3 -0.4 -0.9 0.0 -1.3
Blood clot in the leg (DVT) 0.8 1.0 4.5 0.3 -2.1 -0.5 0.0 0.4
Medication: Paracetamol 1.9 3.1 7.5 -2.7 -0.2 -1.3 0.0 -2.5
Headache pain in last month 1.2 2.0 8.0 0.7 -2.8 -0.1 0.0 1.3
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.2 -0.2 0.3 -1.0 0.0 1.1
Glaucoma (self-reported) 0.4 0.4 1.9 -0.3 0.4 -0.3 0.0 -1.4
Gout (self-reported) 0.2 0.3 1.0 -0.3 0.3 -0.4 0.0 1.0
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 5.0 1.1 -2.2 -0.2 0.0 1.6
Medication: Amlodipine 0.5 0.7 2.0 -0.2 1.1 1.4 0.0 0.1
Medication: Ventolin 100micrograms inhaler 0.6 0.7 3.1 0.1 -1.8 -0.6 0.0 -0.4
Birth weight 0.9 2.0 6.4 1.5 1.3 -0.1 0.0 2.5
Chronic bronchitis/emphysema (mother) 0.8 1.0 2.1 1.3 1.0 1.5 0.0 -0.4
High blood pressure (siblings) 1.1 1.6 4.3 1.9 -0.3 2.1 0.0 -0.5
Forced vital capacity (FVC), Best measure 3.6 13.2 49.0 3.2 -2.1 -1.5 0.0 7.0
Body fat percentage 1.1 4.5 15.6 -1.9 0.2 1.7 0.0 -3.9
Leg fat percentage (right) 1.6 5.7 20.2 -2.6 0.7 0.9 0.0 -4.5
Arm fat-free mass (right) 1.6 8.0 25.6 1.6 -3.3 -0.8 0.0 5.1
Exposure to tobacco smoke outside home 0.5 0.6 1.6 0.3 -1.3 0.3 0.0 -1.2
Comparative body size at age 10 0.4 1.1 3.0 0.1 -0.9 1.3 0.0 -1.7
Number of full brothers 1.0 1.2 3.8 0.6 1.4 2.0 0.0 0.2
Worry too long after embarrassment 0.3 0.6 1.8 -0.7 -0.0 -1.3 0.0 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.7 5.9 2.4 -1.2 2.2 0.0 1.0
Wheeze or whistling in the chest in last year 0.3 0.5 1.6 -0.3 -1.3 0.5 0.0 -0.8
Number of children fathered 2.9 3.3 8.3 -2.9 1.3 -1.3 0.0 -2.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.9 -0.9 0.1 -0.2 0.0 -0.5
Age at first live birth 0.7 1.3 3.8 -1.1 1.9 -0.5 0.0 -1.2
Pulse wave peak to peak time 1.3 1.5 3.7 -1.5 1.9 -0.8 0.0 -0.9
Health satisfaction 0.7 0.9 3.4 0.7 0.9 1.9 0.0 -0.3
Shortness of breath walking on level ground 0.5 0.6 2.2 -0.3 -0.8 -0.2 0.0 -1.5
Qualifications: College or University degree 0.9 2.7 9.3 1.7 -1.0 0.5 0.0 3.0
Eye problems/disorders: None of the above 0.1 0.2 0.5 0.0 0.5 0.3 0.0 0.7
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.8 -1.4 -0.3 -0.2 0.0 -0.2
Emphysema/chronic bronchitis 0.7 0.7 3.6 -0.2 -1.9 0.1 0.0 -0.2
Medication for pain relief, constipation, heartburn 1.0 1.7 4.7 1.1 -1.6 -0.2 0.0 2.2
Neck or shoulder pain in last month 0.5 0.7 1.7 0.9 -0.3 0.9 0.0 1.3
Medication: Blood pressure 0.6 1.1 3.7 0.3 0.4 1.2 0.0 -1.9
Angina (self-reported) 0.2 0.3 0.6 -0.6 -0.8 0.0 0.0 -0.8
Migraine (self-reported) 0.4 0.4 1.4 -0.5 -1.2 -0.7 0.0 -0.3
Medication: Ibuprofen 2.4 2.9 6.0 -2.3 1.5 -1.0 0.0 -2.4
Medication: Allopurinol 0.2 0.2 0.5 0.5 -0.7 0.3 0.0 0.6
Medication: Omeprazole 0.5 0.6 2.5 -1.6 -0.3 -0.3 0.0 -0.8
Medication: Seretide 50 evohaler 1.5 1.7 5.5 1.7 -0.6 2.3 0.0 -0.0
Mean time to correctly identify matches 4.1 7.7 19.5 3.7 -2.0 1.4 0.0 4.4
Heart disease (mother) 2.4 2.9 6.6 2.1 -1.4 1.3 0.0 2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.3 0.8 -1.0 1.1 0.0 0.9
Whole body fat mass 0.3 1.4 2.9 -1.1 -1.1 1.2 0.0 -1.7
Leg fat mass (right) 0.4 1.5 4.2 -1.3 -0.6 1.0 0.0 -2.0
Arm predicted mass (right) 1.5 7.6 27.1 1.5 -2.8 -0.7 0.0 5.2
Pulse rate, automated reading 0.1 0.4 2.0 -0.4 0.2 -1.4 0.0 0.2
Alcohol intake frequency. 0.6 1.4 3.3 1.6 -1.8 1.0 0.0 -0.2
Comparative height size at age 10 4.6 25.2 91.0 2.4 -5.0 -2.2 0.0 9.5
Number of full sisters 0.7 0.8 3.3 0.4 0.8 1.8 0.0 0.0
Suffer from ‘nerves’ 1.1 1.8 6.7 2.6 -0.7 1.0 0.0 0.8
Overall health rating 0.2 0.4 1.5 0.4 -0.7 1.2 0.0 0.0
Chest pain or discomfort 0.2 0.3 1.4 0.3 -1.2 0.2 0.0 0.3
Had major operations 1.2 1.3 5.5 0.0 2.4 1.1 0.0 -0.2
Age at last live birth 0.7 1.0 3.1 -1.1 1.8 -0.6 0.0 -0.3
Family relationship satisfaction 3.2 4.0 8.7 2.7 -0.6 1.8 0.0 2.9
Leg pain on walking 0.6 0.8 1.5 1.2 0.1 1.0 0.0 1.1
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.1 -0.1 0.6 1.4 0.0 -1.5
Commuting to job workplace: Car/motor vehicle 1.2 1.3 2.7 -1.6 0.8 -1.2 0.0 -1.4
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.4 -1.5 0.4 -1.0 0.0 -1.0
Medication: Aspirin 0.1 0.1 0.4 0.3 -0.1 0.6 0.0 0.0
Supplements: Vitamin C 0.6 0.8 2.8 0.5 0.3 0.8 0.0 1.7
Knee pain experienced in last month 0.5 0.7 2.5 -1.6 0.1 -0.9 0.0 -0.5
Hypertension (Self-reported) 0.7 1.9 6.8 0.8 0.8 2.6 0.0 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.0 -1.0 0.6 0.3 0.0 -1.0
Illnesses of father: Heart disease 0.1 0.2 0.5 -0.6 -0.2 -0.7 0.0 0.4
Illnesses of siblings: Diabetes 1.2 1.5 6.1 0.9 -2.5 0.3 0.0 0.7
Smoking status: Previous 1.0 1.5 6.5 0.3 0.6 -0.6 0.0 2.6
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.5 10.8 0.2 -0.3 -1.3 0.0 3.3
Whole body fat-free mass 1.7 9.9 30.6 1.7 -3.9 -1.0 0.0 5.5
Leg fat-free mass (right) 1.4 7.2 17.6 1.9 -3.9 0.2 0.0 4.2
Arm fat percentage (left) 1.5 5.8 21.5 -1.5 -0.4 2.3 0.0 -4.6
Average weekly red wine intake 0.2 0.3 0.8 0.1 0.9 0.8 0.0 0.2
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 -0.6 1.0 -0.3 0.0 -0.9
Mood swings 0.5 0.9 2.3 -0.6 -0.9 -0.9 0.0 -1.5
Loneliness, isolation 4.8 6.6 21.7 2.7 -1.6 1.3 0.0 4.7
Long-standing illness, disability or infirmity 1.5 2.3 4.4 1.6 -2.1 1.4 0.0 1.5
Ever had bowel cancer screening 0.9 1.1 2.6 0.8 -0.1 1.6 0.0 1.5
Diabetes diagnosed by doctor 0.2 0.3 0.8 -0.6 -0.9 -0.4 0.0 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.4 -0.1 0.6 -0.1 0.0 0.6
Friendships satisfaction 2.8 3.5 8.8 2.6 0.1 1.4 0.0 3.0
Qualifications: nursing, teaching 1.4 2.1 7.3 1.5 0.7 0.7 0.0 2.7
Commuting to job workplace: Walk 0.3 0.3 0.8 0.7 -0.3 0.5 0.0 0.9
Eye problems/disorders: Cataract 0.4 0.4 1.0 -0.9 0.5 0.2 0.0 -1.0
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 9.5 -1.3 -1.4 -3.1 0.0 0.4
Medication for cholesterol 0.7 1.0 2.6 -1.0 0.9 -1.6 0.0 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.8 0.3 0.9 0.3 0.0 -0.2
Back pain experienced in last month 0.5 0.8 2.1 -0.6 -0.1 -1.5 0.0 1.2
Mineral and other dietary supplements 1.1 1.5 3.3 -1.3 0.1 -1.6 0.0 -1.8
Breast cancer (self-reported) 0.2 0.2 0.5 0.1 0.6 0.3 0.0 0.7
Asthma (self-reported) 1.5 3.0 6.9 2.6 -1.6 1.9 0.0 1.3
Osteoporosis (self-reported) 1.2 1.5 5.5 -1.1 -0.1 -0.9 0.0 -2.4
Osteoarthritis (self-reported) 0.2 0.2 0.8 -0.1 0.4 0.5 0.0 -0.9
Medication: Aspirin 0.1 0.1 0.3 0.1 -0.6 0.3 0.0 -0.3
Medication: Gliclazide 1.2 1.3 2.9 -1.7 -1.2 -1.5 0.0 -0.1
Illnesses of father: None of the above (group 1) 0.1 0.1 0.4 -0.0 0.7 -0.1 0.0 0.5
Smoking status: Current 0.5 0.7 2.5 -1.6 -0.1 -0.9 0.0 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.9 1.1 -0.7 -0.2 0.0 1.4
Whole body water mass 1.7 9.7 29.6 1.7 -3.9 -1.0 0.0 5.4
Leg predicted mass (right) 1.4 7.4 18.0 1.9 -3.9 0.2 0.0 4.2
Arm fat mass (left) 0.5 1.9 4.9 -0.9 -1.0 1.7 0.0 -2.2
Number of self-reported non-cancer illnesses 1.0 1.7 4.0 1.0 -2.0 1.8 0.0 -0.7
Average weekly champagne plus white wine intake 2.2 3.0 7.0 0.2 2.3 1.6 0.0 -2.6
Miserableness 2.3 4.1 6.8 2.6 -2.4 1.3 0.0 2.5
Guilty feelings 0.1 0.1 0.4 -0.3 0.2 -0.2 0.0 -0.7
Wears glasses or contact lenses 1.2 1.4 2.7 -1.6 -0.4 -1.5 0.0 -1.5
Ever taken oral contraceptive pill 0.5 0.5 1.4 -0.6 0.4 -1.0 0.0 1.2
Hearing aid user 2.8 3.2 5.8 2.4 -0.0 2.3 0.0 2.2
Mother’s age at death 1.7 2.1 8.4 -0.1 2.9 1.4 0.0 -0.2
Financial situation satisfaction 5.0 6.2 12.6 3.5 -1.0 2.6 0.0 3.3
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.8 0.3 0.4 1.3 0.0 0.1
Commuting to job workplace: Public transport 0.6 0.7 2.7 0.9 -0.3 0.2 0.0 1.7
Eye problems/disorders: Glaucoma 1.1 1.2 4.4 -0.9 0.1 -1.1 0.0 -2.1
Medication: Blood pressure 0.2 0.5 1.8 0.3 -0.5 1.3 0.0 -0.4
Pain type(s) experienced in last month: Hip pain 0.4 0.4 1.1 0.6 -0.8 0.3 0.0 -1.0
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.7 1.2 0.7 1.3 0.0 0.9
High cholesterol (Self-reported) 1.5 2.6 5.9 2.4 -1.8 1.8 0.0 0.9
Medication: Bendroflumethiazide 0.3 0.4 1.5 0.4 -0.0 1.2 0.0 -0.5
Medication: Paracetamol 2.5 3.8 10.2 -3.2 -0.3 -1.3 0.0 -2.7
Medication: Lisinopril 0.1 0.1 0.3 -0.1 0.2 0.5 0.0 -0.3
Medication: Atorvastatin 0.1 0.1 0.2 0.5 -0.3 -0.2 0.0 -0.1
Illnesses of father: High blood pressure 0.8 1.0 3.0 -1.7 -0.9 -0.8 0.0 -0.8
Alcohol drinker status: Never 0.6 0.8 1.9 1.4 0.3 1.2 0.0 0.6
Ever smoked 0.7 1.2 4.3 -0.3 1.2 -0.5 0.0 2.1
Basal metabolic rate 1.4 7.5 21.4 1.3 -3.8 -0.7 0.0 4.6
Leg fat percentage (left) 1.7 6.0 20.7 -2.8 0.7 1.0 0.0 -4.6
Arm fat-free mass (left) 1.3 6.5 22.2 1.2 -2.9 -1.0 0.0 4.7
Number of operations (self-reported) 0.4 0.6 1.3 -0.5 1.1 0.8 0.0 -0.8
Average weekly beer plus cider intake 2.9 4.3 8.6 -2.4 -0.1 -2.6 0.0 -2.9
Irritability 0.8 1.4 3.9 1.4 -1.0 0.4 0.0 2.0
Risk taking 1.0 1.4 3.7 -1.9 -0.3 -1.7 0.0 -0.6
Ever had prostate specific antigen (PSA) test 1.2 1.4 3.7 0.8 1.0 1.9 0.0 1.2
Fractured/broken bones in last 5 years 1.6 2.0 5.4 -2.3 1.1 -1.2 0.0 -1.5
Age started oral contraceptive pill 0.1 0.2 0.7 -0.2 0.8 0.1 0.0 0.4
Diastolic blood pressure, automated reading 0.9 2.7 6.3 -2.5 -0.4 -0.8 0.0 -2.5
Ever depressed for a whole week 5.2 6.4 12.6 3.5 -2.5 1.0 0.0 3.6
Unable to work because of sickness or disability 0.4 0.5 1.0 0.7 -1.0 0.5 0.0 1.0
Commuting to job workplace: Cycle 0.7 0.8 1.9 1.4 -0.1 1.0 0.0 1.2
Myopia 1.6 2.4 7.6 -1.2 2.8 0.5 0.0 -1.6
Vascular/heart problems diagnosed by doctor 0.6 1.6 4.2 -0.6 -0.3 -2.0 0.0 1.8
Cholesterol lowering medication 1.1 1.6 3.9 1.7 -2.0 1.2 0.0 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 -0.5 -0.2 0.7 0.0 -0.4
Pain experienced in last month 0.2 0.4 1.3 0.8 0.4 1.1 0.0 0.2
Supplements: Calcium 0.8 0.9 2.3 1.5 -0.4 1.2 0.0 0.9
Basal cell carcinoma (self-reported) 0.8 0.9 3.0 1.1 -1.7 0.1 0.0 0.7
Heart attack/myocardial infarction (self-reported) 0.4 0.6 1.6 -0.3 1.3 0.7 0.0 -0.7
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 6.0 0.4 -2.4 -0.7 0.0 0.6
Heart disease (siblings) 1.5 1.8 3.1 1.8 0.9 1.7 0.0 1.6
Alcohol drinker status: Previous 0.2 0.2 0.5 0.5 -0.3 0.7 0.0 -0.1
Pack years of smoking 0.4 0.6 2.7 0.5 -1.7 -0.1 0.0 0.1
Impedance of whole body 0.3 1.4 5.0 -0.8 2.2 -0.6 0.0 -1.1
Leg fat mass (left) 0.4 1.7 4.7 -1.5 -0.8 0.8 0.0 -2.2
Arm predicted mass (left) 1.3 6.4 22.6 1.2 -2.7 -0.8 0.0 4.8