Hub : Genes

STAU1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0880 0.0320 0.00015 -0.001 0.013 0.002 0.013 -0.002 0.39000 0.0097 0.180 0.0087 0.610
2 GTEx Adrenal Gland 0.1475 0.0614 0.00360 0.000 NA 0.004 NA -0.001 0.31000 NA 0.210 NA 0.370
3 GTEx Cells Transformed fibroblasts 0.0840 0.0350 0.00180 0.034 NA 0.006 NA 0.015 0.00130 NA 0.110 NA 0.023
4 GTEx Testis 0.1190 0.0460 0.00048 0.069 NA 0.016 NA 0.033 0.00056 NA 0.060 NA 0.013
5 TCGA Breast Invasive Carcinoma 0.0125 0.0080 0.00670 0.012 0.008 0.006 NA 0.005 0.00130 0.0061 0.014 NA 0.034

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 2.2 3.4 8.8 1.9 0.0 -3.0 -1.8 -1.2
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 0.5 0.0 -0.1 0.2 0.4
Depressed Affect (Nagel 2018) 0.9 2.0 7.4 -0.7 0.0 2.7 1.1 0.8
Depression (Nagel 2018) 2.9 4.3 12.5 -2.3 0.0 3.5 1.9 0.3
Intelligence (Savage-Jansen 2018) 7.6 23.5 62.9 -6.3 0.0 7.9 3.4 1.8
Neuroticism (Nagel 2018) 0.8 1.8 6.1 -0.8 0.0 2.5 1.0 1.2
Schizophrenia (2018) 1.1 2.2 5.1 -0.9 0.0 2.3 1.7 1.5
Schizophrenia vs Biploar Disorder 5.4 7.1 13.1 -3.0 0.0 3.6 3.0 2.2
Worry (Nagel 2018) 1.0 2.1 3.6 -1.7 0.0 1.9 1.7 1.0
Alzheimer’s Disease (in mother) 0.3 0.3 1.4 -0.0 0.0 0.1 1.2 0.4
Alzheimer’s Disease (in father) 2.3 2.4 6.9 -2.2 0.0 2.6 0.4 -0.3
Alzheimer’s Disease (including proxy) 0.5 0.7 1.6 -1.3 0.0 0.9 1.1 0.2
Crohns Disease (2017) 0.9 2.1 10.0 3.2 0.0 -0.6 -0.2 0.1
Irritable Bowel Disease (IBD) 0.2 0.5 1.7 1.3 0.0 -0.4 -0.4 -0.5
Ulcerative Colitis (UC) 0.1 0.3 0.8 -0.7 0.0 0.2 -0.2 -0.9
Major Depression (MDD) 1.6 2.0 7.7 -2.8 0.0 1.3 0.6 0.4
Reaction Time 4.6 8.8 22.0 -4.1 0.0 4.7 2.3 0.4
Verbal and Numeric Reasoning (VNR) 7.6 18.1 40.1 -5.7 0.0 6.3 3.6 2.4
Breast Cancer 0.5 1.2 3.3 -1.5 0.0 1.8 -0.1 0.6
Ovarian Cancer 1.7 2.2 6.5 -2.5 0.0 2.0 -0.4 -0.5
Prostate Cancer 0.5 0.6 1.8 -0.6 0.0 -1.3 -0.9 -0.6
Age at First Birth 0.4 0.6 2.4 -0.6 0.0 -0.4 1.6 0.4
Bipolar Disorder (2011) 3.2 3.1 10.4 2.2 0.0 -3.2 0.0 -0.1
Body Mass Index (BMI) (2010) 1.5 2.1 3.6 1.5 0.0 -1.9 1.5 1.5
Coronary Artery Disease (CAD) 1.0 1.2 3.6 0.5 0.0 -1.9 -0.3 1.4
Crohns Disease (2012) 0.7 1.0 4.5 2.1 0.0 -0.6 -0.1 0.7
Mean Putamen Volume 0.3 0.3 0.9 -0.7 0.0 -0.3 -0.1 0.9
Fasting Glucose 0.9 1.1 3.6 0.9 0.0 -1.9 0.1 1.1
HbA1C 0.5 0.5 1.1 1.0 0.0 -0.7 -0.8 -0.7
HDL Cholesterol 1.0 1.6 5.1 2.3 0.0 -0.9 -1.0 -1.1
LDL Cholesterol 0.8 1.2 4.5 -0.9 0.0 2.1 0.7 0.6
Lupus 0.3 0.4 0.9 -0.3 0.0 1.0 -0.0 -0.9
Neuroticism (2016) 0.5 0.7 1.6 0.0 0.0 1.2 1.0 0.9
Primary Biliary Cirrhosis 0.5 0.6 1.4 1.2 0.0 -1.2 -0.6 -0.2
Rheumatoid Arthritis 0.8 1.2 4.2 2.1 0.0 -1.2 -0.4 -0.0
Schizophrenia (2014) 1.2 2.6 4.8 -1.2 0.0 2.2 2.2 1.5
Triglycerides 0.5 0.8 3.3 -0.2 0.0 -0.1 0.8 1.8
Type 2 Diabetes (T2D) (2012) 0.2 0.2 1.0 1.0 0.0 -0.1 -0.4 -0.1
Ulcerative Colitis 0.4 0.6 1.0 -0.6 0.0 -0.8 -1.0 -0.9
Blood Eosinophil Count 0.1 1.1 3.4 -1.3 0.0 1.8 0.4 0.1
Blood Platelet Count 0.3 3.3 11.4 2.1 0.0 -0.2 -3.4 -0.6
Blood Red Count 0.2 2.1 8.3 0.9 0.0 2.9 1.0 0.3
Blood White Count 0.5 3.3 8.8 1.5 0.0 -0.1 2.4 3.0
Heel T-Score 0.1 0.9 1.7 1.3 0.0 1.0 -1.1 0.7
BMI 2.9 16.7 34.4 5.9 0.0 -4.7 1.0 5.1
Height 4.7 90.1 269.0 -6.4 0.0 16.4 -3.2 -11.4
Waist Hip Ratio (WHR) 0.2 0.7 2.7 -0.6 0.0 1.6 0.5 -0.6
Systolic Blood Pressure 1.7 8.8 29.1 -2.3 0.0 -5.4 0.6 3.0
Smoking Status 0.8 1.8 5.6 1.1 0.0 2.4 1.4 -0.6
Allergy or Eczema 1.8 4.8 8.9 -2.0 0.0 2.0 2.7 3.0
Cardiovascular Disease 2.2 7.4 12.7 -3.5 0.0 -2.6 2.3 3.6
Hypothyroidism (self reported) 0.7 1.5 6.4 -2.5 0.0 1.1 -0.0 0.2
Respiratory disease 0.3 0.6 2.0 1.4 0.0 0.8 0.6 -0.5
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.3 0.8 0.0 -1.1 0.5 0.8
Lung FEV1/FVC ratio 0.5 2.7 11.5 1.1 0.0 -3.4 -0.6 0.8
Lung FVC 2.1 10.6 22.6 -3.6 0.0 4.8 0.9 -4.1
Neuroticism 1.2 2.9 10.6 -1.3 0.0 3.3 1.3 0.8
Chronotype (morning person) 0.6 1.3 2.9 -1.7 0.0 0.9 -1.1 -1.3
Hair Pigment 0.1 3.3 9.5 0.5 0.0 3.1 -0.4 -2.6
Tanning 0.1 1.1 3.8 0.2 0.0 2.0 -0.6 -1.2
Hand grip strength (left) 3.1 8.1 25.5 -2.4 0.0 5.0 -1.0 -2.9
Number of treatments/medications taken 1.9 3.4 8.6 -0.3 0.0 -2.4 1.7 2.9
Average weekly spirits intake 1.0 1.2 2.8 -1.4 0.0 1.7 -0.9 -0.7
Sensitivity / hurt feelings 0.5 0.8 2.6 1.6 0.0 0.1 0.4 1.2
Frequency of depressed mood in last 2 weeks 4.4 6.2 21.4 -2.6 0.0 4.6 1.6 0.5
Hearing difficulty/problems: Yes 0.9 1.4 4.5 0.2 0.0 0.7 2.1 1.4
Relative age of first facial hair 0.2 0.4 1.1 -0.5 0.0 1.0 -0.2 -0.7
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.3 -0.7 0.0 0.6 1.1 1.0
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.6 1.6 0.0 -0.6 0.1 0.3
Ever had hysterectomy (womb removed) 0.4 0.4 1.7 -0.5 0.0 0.2 1.3 0.5
Systolic blood pressure, automated reading 1.1 3.1 11.7 -0.4 0.0 -3.4 -0.5 1.9
Eye problems/disorders: Diabetes related eye disease 0.1 0.2 0.5 -0.4 0.0 0.4 -0.7 -0.1
Angina 0.2 0.3 1.1 0.0 0.0 -0.3 -0.3 1.1
Medication for hormone replacement therapy 1.5 1.7 4.8 0.7 0.0 -0.2 1.7 2.2
Vitamin and mineral supplements 0.4 0.6 2.4 0.4 0.0 -1.5 0.2 0.5
Supplements: Zinc 1.1 1.2 2.2 -1.2 0.0 0.9 1.3 1.5
Medication: Co-codamol 0.1 0.1 0.5 -0.3 0.0 0.2 0.7 -0.1
Medication: Metformin 0.4 0.6 1.3 0.5 0.0 -0.9 0.8 1.1
Diabetes (father) 1.4 1.7 4.6 2.1 0.0 -1.7 -0.9 0.4
Diabetes (mother) 0.3 0.4 1.0 -0.2 0.0 -0.9 -1.0 0.4
Severe depression (siblings) 0.1 0.1 0.6 0.2 0.0 0.3 -0.1 0.8
Pack years adult smoking proportion 0.9 1.3 4.6 2.2 0.0 -0.8 -1.1 0.1
Impedance of leg (right) 0.0 0.2 0.8 -0.9 0.0 -0.0 -0.3 -0.5
Leg fat-free mass (left) 0.8 4.1 15.4 0.5 0.0 3.9 -0.9 -2.0
Trunk fat percentage 2.3 9.1 21.8 4.7 0.0 -3.3 1.0 3.4
Hand grip strength (right) 3.9 10.6 33.8 -3.1 0.0 5.8 -0.9 -3.0
Townsend deprivation index at recruitment 0.0 0.0 0.1 -0.0 0.0 -0.0 0.1 0.3
Current tobacco smoking 0.8 1.3 3.2 1.8 0.0 -1.5 -0.4 -0.8
Average weekly fortified wine intake 1.0 1.2 5.4 -2.3 0.0 0.7 0.1 -0.1
Maternal smoking around birth 0.7 1.0 3.0 -1.1 0.0 1.7 0.9 0.2
Fed-up feelings 0.4 0.8 2.0 0.8 0.0 1.4 1.0 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 2.7 3.6 7.0 -2.6 0.0 2.3 2.1 1.0
Relative age voice broke 0.4 0.6 1.1 -1.0 0.0 0.3 1.0 0.8
Taking other prescription medications 1.5 2.4 4.8 -0.3 0.0 -2.1 1.5 2.2
Age when periods started (menarche) 0.1 0.3 0.5 -0.7 0.0 -0.3 0.4 0.7
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 6.1 0.2 0.0 0.6 2.5 0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.5 0.1 0.0 -0.2 -1.2 0.5
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 3.7 0.8 0.0 -0.3 -1.9 -1.8
Qualifications: CSEs or equivalent 0.8 1.0 2.6 1.4 0.0 -0.7 -1.6 -0.2
Serious illness, injury or assault to yourself 1.2 1.4 5.7 -2.4 0.0 1.0 0.4 0.1
High blood pressure 2.3 6.4 15.0 -1.6 0.0 -3.9 2.4 2.9
Hayfever, allergic rhinitis or eczema 1.8 3.9 11.4 -1.8 0.0 0.6 2.2 3.4
Multivitamins +/- minerals 0.2 0.3 1.1 -0.0 0.0 0.4 0.4 1.0
Stomach or abdominal pain in last month 0.1 0.2 0.5 0.6 0.0 -0.2 0.0 0.7
Supplements: Glucosamine 0.8 1.0 2.6 -0.2 0.0 -0.4 1.5 1.6
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 4.2 1.3 0.0 -2.0 -0.0 0.5
Medication: Atenolol 0.9 1.1 3.7 -0.8 0.0 -1.9 -0.8 0.7
Medication: Levothyroxine sodium 0.8 1.3 2.3 -1.5 0.0 1.3 -0.9 -1.4
Sitting height 3.7 26.1 93.1 -4.2 0.0 9.7 0.4 -4.5
Chronic bronchitis/emphysema (father) 1.3 1.5 3.3 1.8 0.0 -1.8 -0.6 -0.7
High blood pressure (mother) 2.0 2.9 6.5 1.8 0.0 -2.5 0.6 2.0
Body mass index (BMI) 2.5 10.5 22.1 4.7 0.0 -3.7 0.9 4.0
Impedance of leg (left) 0.1 0.2 0.8 -0.9 0.0 -0.1 -0.3 -0.6
Leg predicted mass (left) 0.8 4.1 15.1 0.6 0.0 3.9 -0.9 -2.1
Trunk fat mass 1.0 4.5 16.0 4.0 0.0 -1.3 0.6 2.1
Waist circumference 0.7 2.6 6.1 2.3 0.0 -0.4 1.2 2.5
Number of incorrect matches in round 1.5 2.5 9.3 1.3 0.0 -3.0 1.0 0.8
Past tobacco smoking 1.7 3.2 10.3 0.1 0.0 -3.2 -2.3 -0.5
Alcohol usually taken with meals 1.0 1.6 3.7 -0.1 0.0 -1.9 1.7 1.3
Nervous feelings 0.4 0.7 2.0 -0.7 0.0 1.4 -0.3 -1.0
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.5 6.1 -1.1 0.0 2.5 0.2 0.2
Hearing difficulty/problems with background noise 1.1 1.8 4.7 -0.2 0.0 2.1 2.2 0.1
Hair/balding pattern: Pattern 2 0.2 0.3 1.1 1.0 0.0 0.3 0.6 0.2
Had menopause 0.6 0.7 1.1 1.0 0.0 1.1 0.4 -1.1
Had other major operations 1.3 1.6 5.6 -0.6 0.0 -0.6 1.3 2.4
Forced vital capacity (FVC) 6.6 25.3 65.1 -3.9 0.0 8.1 -1.3 -6.7
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.7 -0.4 0.0 -0.2 -1.3 0.6
Ever unenthusiastic/disinterested for a whole week 5.1 6.2 16.4 -4.1 0.0 3.7 0.2 -0.9
Qualifications: None of the above 1.8 3.9 9.8 2.8 0.0 -3.1 -1.4 0.2
Financial difficulties in last 2 years 3.8 5.1 10.8 -1.4 0.0 2.0 2.9 3.3
Mouth/teeth dental problems 1.0 1.6 7.4 -2.7 0.0 0.3 0.2 -0.7
Heart attack 1.6 2.1 6.2 -0.0 0.0 -2.5 1.4 1.5
Allergy 0.8 1.9 4.8 0.7 0.0 -0.3 -2.1 -2.2
Pain all over the body in last month 0.9 0.9 3.2 -0.7 0.0 0.5 0.8 1.8
Diabetes (self-reported) 0.9 1.4 3.3 -1.3 0.0 0.1 1.8 1.3
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 2.0 0.8 0.0 0.5 0.3 1.4
Medication: Ramipril 1.0 1.3 3.2 -0.1 0.0 -1.8 1.1 1.4
Medication: Simvastatin 1.0 1.4 5.3 -1.0 0.0 -0.6 0.7 2.3
Fluid intelligence score 3.2 6.7 12.9 -3.5 0.0 3.6 2.3 1.8
Illnesses of siblings 0.2 0.3 0.9 0.1 0.0 0.1 -0.9 -0.9
Neuroticism score 0.6 1.2 5.3 0.2 0.0 2.3 0.6 0.2
Weight 0.4 1.8 4.7 2.2 0.0 2.0 -0.1 -0.1
Impedance of arm (right) 0.1 0.4 1.9 -1.4 0.0 -0.4 -0.1 -0.2
Arm fat percentage (right) 3.4 13.3 25.6 5.1 0.0 -4.7 1.0 4.2
Trunk fat-free mass 2.4 14.0 44.5 -1.4 0.0 6.7 -1.7 -4.5
Hip circumference 0.3 1.3 3.6 1.6 0.0 0.4 0.5 1.9
Time employed in main current job 2.0 2.3 6.0 2.5 0.0 -1.6 -1.1 -1.2
Alcohol intake versus 10 years previously 0.6 0.8 2.7 0.0 0.0 -0.6 1.0 1.6
Father’s age at death 0.8 1.1 4.9 2.2 0.0 -0.2 -0.7 -0.4
Worrier / anxious feelings 1.2 2.2 4.4 -1.1 0.0 2.1 1.9 1.4
Frequency of tiredness / lethargy in last 2 weeks 2.9 4.8 13.0 -2.9 0.0 3.6 1.5 0.3
Falls in the last year 0.4 0.5 1.6 0.9 0.0 -0.0 1.3 -0.1
Hair/balding pattern: Pattern 3 0.9 1.3 4.9 -2.2 0.0 1.3 0.3 -0.2
Number of live births 0.8 1.2 2.9 1.5 0.0 -1.7 0.2 -0.8
Forced expiratory volume in 1-second (FEV1) 4.8 16.2 36.8 -3.5 0.0 6.1 -1.5 -5.5
Pulse rate 0.2 0.3 1.0 -0.2 0.0 1.0 0.3 0.5
Happiness 2.9 3.6 12.1 -1.7 0.0 3.5 1.1 -1.3
Noisy workplace 0.1 0.1 0.1 0.3 0.0 -0.1 0.4 0.4
Qualifications: A levels/AS levels or equivalent 2.5 5.6 19.2 -2.9 0.0 4.4 0.2 -0.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.8 0.3 0.0 0.9 0.3 0.2
Mouth/teeth dental problems: Dentures 1.6 2.7 5.5 1.5 0.0 -1.1 2.2 2.3
Asthma 0.4 0.7 1.8 1.2 0.0 0.6 1.3 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.2 0.8 0.0 -1.1 -0.5 0.5
Medication: Cholesterol lowering 2.3 3.5 10.3 -1.4 0.0 -0.4 2.3 3.2
Depression (self-reported) 0.2 0.2 0.6 -0.6 0.0 0.8 -0.1 0.2
Medication: Lansoprazole 0.2 0.2 0.8 0.9 0.0 -0.3 0.1 0.1
Prospective memory result 0.5 0.6 1.9 1.4 0.0 -0.8 -0.4 -0.5
Lung cancer (father) 2.1 2.5 6.9 0.6 0.0 0.1 2.6 2.3
Illnesses of mother 0.6 0.8 2.8 0.2 0.0 1.7 -0.8 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 4.4 14.1 29.7 -3.7 0.0 5.5 -1.0 -5.1
Pulse wave Arterial Stiffness index 0.6 0.7 1.9 -1.4 0.0 1.0 -0.6 -0.0
Impedance of arm (left) 0.2 0.7 2.4 -1.6 0.0 -0.7 0.5 0.6
Arm fat mass (right) 1.3 5.3 15.5 3.9 0.0 -2.0 0.5 2.6
Trunk predicted mass 2.4 13.5 43.0 -1.4 0.0 6.6 -1.7 -4.4
Standing height 5.1 50.3 146.7 -5.3 0.0 12.1 -2.1 -8.5
Length of working week for main job 1.0 1.1 4.4 0.7 0.0 -0.7 0.2 2.1
Exposure to tobacco smoke at home 0.3 0.3 0.8 -0.9 0.0 -0.1 -0.9 0.2
Breastfed as a baby 0.2 0.2 0.6 0.8 0.0 0.7 0.2 -0.3
Tense / ‘highly strung’ 1.8 3.0 7.9 -2.5 0.0 2.8 0.2 -1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.2 -1.5 0.0 1.2 0.5 0.4
Hair/balding pattern: Pattern 4 0.9 2.2 5.3 0.9 0.0 -2.3 -1.4 -1.8
Birth weight of first child 2.2 3.9 13.8 -1.2 0.0 3.7 -0.4 -2.1
Peak expiratory flow (PEF) 2.9 6.7 13.0 -1.9 0.0 3.6 -2.1 -3.5
Pulse wave reflection index 0.8 1.0 4.1 -2.0 0.0 0.2 0.4 0.7
Ever highly irritable/argumentative for 2 days 2.7 3.3 14.0 -0.9 0.0 3.7 1.2 -0.5
Loud music exposure frequency 0.4 0.5 1.3 1.1 0.0 -0.2 -0.9 -0.4
Qualifications: O levels/GCSEs or equivalent 2.3 3.6 9.2 -1.6 0.0 3.0 2.5 0.5
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 9.3 3.0 0.0 0.1 -0.9 1.1
Blood clot in the leg (DVT) 0.4 0.5 1.1 -0.4 0.0 0.3 -1.1 -1.0
Medication: Paracetamol 1.0 1.7 4.6 2.1 0.0 -1.7 -0.9 0.2
Headache pain in last month 0.3 0.5 1.9 -0.6 0.0 1.4 -0.4 -0.2
Medication for cholesterol, blood pressure or diabetes 2.2 3.6 7.6 1.0 0.0 2.3 -2.0 -2.8
Glaucoma (self-reported) 0.8 1.0 3.2 1.1 0.0 -1.8 -0.7 0.1
Gout (self-reported) 0.5 0.7 2.5 -0.2 0.0 1.6 -0.3 -0.8
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 3.8 -2.0 0.0 1.2 -1.3 -1.2
Medication: Amlodipine 1.0 1.5 4.2 -1.6 0.0 -2.0 0.8 -0.3
Medication: Ventolin 100micrograms inhaler 0.9 1.2 3.9 2.0 0.0 -1.2 -0.4 -0.7
Birth weight 1.5 3.2 11.7 1.7 0.0 3.4 0.4 -1.1
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.2 -0.7 0.0 -0.5 1.2 1.5
High blood pressure (siblings) 0.6 0.8 1.5 0.2 0.0 -1.2 1.2 1.1
Forced vital capacity (FVC), Best measure 6.4 23.3 57.0 -4.7 0.0 7.5 -0.6 -6.1
Body fat percentage 3.0 12.0 26.0 5.1 0.0 -4.1 1.1 4.0
Leg fat percentage (right) 3.6 13.2 31.1 5.6 0.0 -4.5 0.5 3.7
Arm fat-free mass (right) 1.4 6.9 24.7 0.2 0.0 5.0 -1.1 -3.0
Exposure to tobacco smoke outside home 0.2 0.3 0.7 -0.8 0.0 0.1 -0.8 0.4
Comparative body size at age 10 0.7 2.0 4.9 2.2 0.0 -2.2 0.2 0.1
Number of full brothers 1.3 1.7 4.0 1.0 0.0 -0.8 2.0 1.7
Worry too long after embarrassment 0.6 1.0 1.3 1.2 0.0 1.1 -1.1 -1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 3.0 -1.2 0.0 0.8 1.7 1.0
Wheeze or whistling in the chest in last year 1.3 2.3 7.1 2.7 0.0 -1.6 0.7 1.3
Number of children fathered 2.6 3.0 8.3 2.9 0.0 -2.2 -0.4 1.2
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.7 1.2 0.0 0.1 0.5 1.3
Age at first live birth 0.1 0.3 1.0 -1.0 0.0 -0.4 0.3 0.2
Pulse wave peak to peak time 0.3 0.4 1.2 1.1 0.0 -0.3 0.5 -0.4
Health satisfaction 1.0 1.4 3.6 -0.5 0.0 -1.2 1.9 1.2
Shortness of breath walking on level ground 0.7 0.8 2.6 1.6 0.0 -1.0 -0.6 -0.4
Qualifications: College or University degree 2.8 8.9 23.6 -4.9 0.0 4.5 0.2 -0.8
Eye problems/disorders: None of the above 0.4 0.5 1.2 -0.7 0.0 1.1 0.6 0.5
Mouth/teeth dental problems: Loose teeth 0.2 0.2 1.0 1.0 0.0 -0.0 0.3 0.2
Emphysema/chronic bronchitis 0.9 1.0 3.0 1.3 0.0 -1.7 0.5 -0.3
Medication for pain relief, constipation, heartburn 0.7 1.3 4.0 -0.5 0.0 2.0 -0.4 -1.3
Neck or shoulder pain in last month 0.8 1.1 2.6 1.6 0.0 1.3 1.2 0.2
Medication: Blood pressure 2.1 3.8 9.3 -1.3 0.0 -3.0 1.7 2.2
Angina (self-reported) 0.2 0.2 1.2 0.0 0.0 -0.1 -0.2 1.1
Migraine (self-reported) 0.2 0.2 1.1 0.1 0.0 1.1 0.1 0.1
Medication: Ibuprofen 1.0 1.2 3.9 2.0 0.0 -1.3 -0.6 -0.1
Medication: Allopurinol 0.3 0.4 1.7 0.1 0.0 1.3 -0.5 -0.1
Medication: Omeprazole 0.6 0.8 1.5 1.0 0.0 -1.2 -0.6 -0.9
Medication: Seretide 50 evohaler 0.2 0.2 0.7 0.4 0.0 -0.8 -0.1 -0.2
Mean time to correctly identify matches 4.4 8.4 22.5 -4.1 0.0 4.7 1.8 -0.2
Heart disease (mother) 1.0 1.3 3.6 -1.2 0.0 1.9 1.1 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.8 -1.7 0.0 0.8 1.3 1.2
Whole body fat mass 1.3 5.4 18.3 4.3 0.0 -1.7 0.6 2.3
Leg fat mass (right) 1.6 6.3 19.8 4.4 0.0 -2.2 0.5 2.5
Arm predicted mass (right) 1.4 7.2 27.3 -0.1 0.0 5.2 -0.8 -2.8
Pulse rate, automated reading 0.1 0.3 0.8 0.5 0.0 0.9 0.3 -0.4
Alcohol intake frequency. 0.1 0.2 0.8 -0.9 0.0 -0.2 0.0 0.4
Comparative height size at age 10 5.6 30.7 69.7 -3.2 0.0 8.3 -3.1 -8.0
Number of full sisters 1.8 2.2 4.2 1.8 0.0 -0.7 2.0 1.8
Suffer from ‘nerves’ 0.5 0.8 3.9 0.1 0.0 2.0 0.4 0.3
Overall health rating 0.3 0.6 1.7 -0.1 0.0 -0.4 1.3 1.1
Chest pain or discomfort 0.1 0.2 0.4 0.4 0.0 0.7 -0.3 0.4
Had major operations 0.9 1.1 2.9 0.6 0.0 -1.3 1.7 0.6
Age at last live birth 0.1 0.2 0.4 0.2 0.0 -0.4 0.6 -0.6
Family relationship satisfaction 2.1 2.6 7.1 -2.0 0.0 2.7 0.6 -1.4
Leg pain on walking 0.3 0.4 1.8 0.1 0.0 0.3 1.3 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 4.5 0.4 0.0 -0.9 1.2 2.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.6 0.1 0.0 -1.9 -0.7 -0.1
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.6 1.6 0.0 -0.5 -1.2 -1.4
Medication: Aspirin 0.6 0.8 2.6 -1.6 0.0 -0.6 0.7 0.7
Supplements: Vitamin C 0.6 0.7 2.8 -0.4 0.0 1.7 0.5 -0.2
Knee pain experienced in last month 1.4 2.2 8.6 2.9 0.0 -1.5 0.1 -0.2
Hypertension (Self-reported) 2.5 7.0 12.7 -2.1 0.0 -3.6 2.8 3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 1.0 1.0 0.0 -0.4 -0.3 -0.1
Illnesses of father: Heart disease 0.2 0.2 0.9 0.3 0.0 1.0 -0.3 -0.2
Illnesses of siblings: Diabetes 0.1 0.1 0.4 -0.6 0.0 0.1 -0.1 0.4
Smoking status: Previous 2.6 3.8 12.2 -0.4 0.0 3.5 2.6 0.4
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.4 10.1 -1.2 0.0 3.2 -0.4 -2.2
Whole body fat-free mass 1.7 9.5 32.0 -0.5 0.0 5.7 -1.3 -3.6
Leg fat-free mass (right) 0.8 4.5 17.3 0.1 0.0 4.2 -0.8 -2.2
Arm fat percentage (left) 3.7 14.7 25.8 5.1 0.0 -4.9 1.3 4.7
Average weekly red wine intake 0.1 0.2 0.7 0.1 0.0 -0.1 0.8 0.2
Handedness (chirality/laterality): Left-handed 0.8 1.0 4.6 2.1 0.0 -0.4 0.4 -0.1
Mood swings 0.4 0.7 2.9 0.7 0.0 -0.4 -1.7 -0.1
Loneliness, isolation 4.4 6.0 24.3 -0.9 0.0 4.9 2.2 0.6
Long-standing illness, disability or infirmity 1.5 2.2 4.7 -1.4 0.0 0.5 2.1 2.2
Ever had bowel cancer screening 0.1 0.1 0.4 0.6 0.0 -0.5 0.2 0.1
Diabetes diagnosed by doctor 0.7 1.1 2.2 -1.2 0.0 -0.3 1.5 1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 2.0 1.4 0.0 -0.5 1.3 1.1
Friendships satisfaction 2.3 2.8 6.5 -2.5 0.0 2.3 0.5 -1.5
Qualifications: nursing, teaching 1.1 1.7 5.8 -2.4 0.0 1.4 0.6 -0.4
Commuting to job workplace: Walk 2.0 2.1 7.3 -0.5 0.0 2.7 1.3 1.2
Eye problems/disorders: Cataract 1.1 1.2 4.4 0.9 0.0 -2.1 -0.7 -0.6
Mouth/teeth dental problems: Mouth ulcers 2.4 3.7 11.8 0.1 0.0 1.7 -2.0 -3.4
Medication for cholesterol 1.3 1.9 5.1 1.0 0.0 1.7 -0.8 -2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.9 -0.1 0.0 -0.9 0.9 0.1
Back pain experienced in last month 1.1 1.6 5.7 1.5 0.0 0.5 -0.4 -2.4
Mineral and other dietary supplements 0.4 0.5 1.9 1.4 0.0 -0.3 -0.7 -0.3
Breast cancer (self-reported) 0.4 0.4 1.0 0.1 0.0 0.9 1.0 0.6
Asthma (self-reported) 0.3 0.5 1.2 1.0 0.0 0.6 1.1 0.5
Osteoporosis (self-reported) 1.2 1.4 5.9 0.9 0.0 -2.4 -0.6 0.3
Osteoarthritis (self-reported) 1.0 1.3 4.2 0.9 0.0 -0.3 1.1 2.0
Medication: Aspirin 0.6 0.7 2.9 -1.7 0.0 -0.7 0.2 0.4
Medication: Gliclazide 0.4 0.5 1.1 -0.2 0.0 0.9 -0.6 -1.1
Illnesses of father: None of the above (group 1) 0.2 0.2 0.5 -0.3 0.0 -0.0 0.7 -0.7
Smoking status: Current 1.1 1.7 4.8 2.2 0.0 -1.6 -0.7 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 9.9 -3.1 0.0 1.8 -0.5 -1.6
Whole body water mass 1.6 9.4 31.6 -0.5 0.0 5.6 -1.4 -3.6
Leg predicted mass (right) 0.9 4.7 17.7 0.1 0.0 4.2 -0.8 -2.2
Arm fat mass (left) 1.6 6.4 17.2 4.1 0.0 -2.4 0.9 2.9
Number of self-reported non-cancer illnesses 1.8 3.1 8.0 0.3 0.0 -1.7 2.1 2.8
Average weekly champagne plus white wine intake 2.1 2.9 11.0 1.1 0.0 -3.3 -0.2 1.5
Miserableness 1.7 2.9 11.1 -1.4 0.0 3.3 0.9 0.8
Guilty feelings 0.4 0.6 1.7 1.3 0.0 -0.1 -1.0 -0.4
Wears glasses or contact lenses 0.7 0.8 2.4 1.6 0.0 -0.4 -1.1 -0.3
Ever taken oral contraceptive pill 0.5 0.6 2.2 -0.8 0.0 1.5 0.2 -0.2
Hearing aid user 1.0 1.2 3.3 -0.3 0.0 1.2 1.8 1.1
Mother’s age at death 2.3 2.9 4.8 2.0 0.0 -1.8 2.2 1.5
Financial situation satisfaction 2.3 2.9 6.4 -1.5 0.0 1.8 2.5 1.5
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.1 0.4 0.0 -0.4 0.4 1.1
Commuting to job workplace: Public transport 1.2 1.4 6.0 -0.1 0.0 2.5 0.8 0.6
Eye problems/disorders: Glaucoma 1.6 1.9 4.2 1.6 0.0 -1.6 -2.1 -0.6
Medication: Blood pressure 0.7 1.3 4.6 -1.1 0.0 -2.1 0.2 0.9
Pain type(s) experienced in last month: Hip pain 0.1 0.2 0.5 0.2 0.0 -0.5 -0.7 0.4
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.3 -1.1 0.0 -0.2 0.9 0.7
High cholesterol (Self-reported) 1.5 2.7 7.3 -2.7 0.0 0.8 1.2 2.1
Medication: Bendroflumethiazide 1.1 1.7 4.4 -1.5 0.0 -2.1 1.1 0.8
Medication: Paracetamol 1.4 2.2 7.6 2.8 0.0 -1.5 -0.4 0.8
Medication: Lisinopril 0.3 0.4 1.2 -1.1 0.0 -0.9 -0.1 0.3
Medication: Atorvastatin 0.6 0.7 2.4 -1.5 0.0 -0.3 1.0 -0.1
Illnesses of father: High blood pressure 0.5 0.6 1.8 0.5 0.0 -1.3 -1.0 0.1
Alcohol drinker status: Never 0.3 0.3 1.3 0.3 0.0 0.1 1.1 0.4
Ever smoked 1.1 1.9 5.0 -0.1 0.0 2.1 2.2 0.3
Basal metabolic rate 1.2 6.7 23.8 0.2 0.0 4.9 -1.2 -2.8
Leg fat percentage (left) 3.8 13.6 32.0 5.7 0.0 -4.7 0.6 3.6
Arm fat-free mass (left) 1.4 6.9 23.4 0.3 0.0 4.8 -1.1 -3.1
Number of operations (self-reported) 1.1 1.7 5.3 1.1 0.0 -2.3 1.0 1.0
Average weekly beer plus cider intake 0.8 1.1 2.8 0.9 0.0 -1.4 -1.7 0.3
Irritability 0.8 1.3 3.7 -0.8 0.0 1.9 -0.3 -1.4
Risk taking 0.4 0.6 1.5 0.7 0.0 -1.2 -0.9 -0.3
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.0 -0.2 0.0 -0.6 1.0 0.4
Fractured/broken bones in last 5 years 0.2 0.3 1.2 -0.4 0.0 -1.1 -0.1 0.5
Age started oral contraceptive pill 0.5 0.6 1.9 0.5 0.0 0.8 -0.1 -1.4
Diastolic blood pressure, automated reading 0.9 2.7 8.1 -1.1 0.0 -2.8 -2.1 0.2
Ever depressed for a whole week 7.5 9.2 26.5 -5.1 0.0 4.2 0.9 1.1
Unable to work because of sickness or disability 0.4 0.6 1.8 -0.9 0.0 1.3 -0.4 -0.0
Commuting to job workplace: Cycle 1.3 1.5 3.9 -2.0 0.0 1.3 1.2 0.7
Myopia 1.0 1.4 4.6 0.3 0.0 -2.1 1.0 1.1
Vascular/heart problems diagnosed by doctor 2.0 5.4 13.8 1.6 0.0 3.7 -1.9 -2.7
Cholesterol lowering medication 0.2 0.3 0.5 -0.7 0.0 -0.5 -0.7 0.6
Medication: Omeprazole (e.g. Zanprol) 0.2 0.3 1.0 0.6 0.0 -1.0 0.4 -0.0
Pain experienced in last month 0.7 1.2 5.3 -2.3 0.0 0.5 0.4 0.6
Supplements: Calcium 0.4 0.4 0.8 0.5 0.0 0.2 0.9 0.9
Basal cell carcinoma (self-reported) 0.2 0.3 0.4 -0.4 0.0 0.6 -0.6 -0.5
Heart attack/myocardial infarction (self-reported) 1.3 1.7 4.3 -0.3 0.0 -2.1 1.4 1.5
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.2 -0.6 0.0 0.6 -1.1 -1.1
Heart disease (siblings) 0.7 0.9 2.2 0.3 0.0 1.2 1.5 0.9
Alcohol drinker status: Previous 0.4 0.4 1.4 -1.2 0.0 0.5 0.4 0.4
Pack years of smoking 0.6 0.8 3.1 1.8 0.0 -0.6 -0.9 0.2
Impedance of whole body 0.1 0.4 1.5 -1.2 0.0 -0.5 0.2 0.3
Leg fat mass (left) 1.6 6.4 21.3 4.6 0.0 -2.3 0.4 2.2
Arm predicted mass (left) 1.3 6.6 23.5 0.2 0.0 4.8 -0.9 -2.9