Best TWAS P=1.18e-13 · Best GWAS P=5.06e-12 conditioned to 0.0261
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RNF181 | 0.07 | 0.02 | bslmm | 476 | 0.03 | 3.4e-04 | 5.4 | 5.4 | 7.4e-08 | 0.59 | 0.02 | 0.91 | FALSE |
2 | GTEx | Adipose Subcutaneous | GGCX | 0.16 | 0.09 | lasso | 5 | 0.08 | 3.1e-07 | 5.5 | 5.4 | 5.6e-08 | 0.71 | 0.86 | 0.14 | FALSE |
3 | GTEx | Adipose Visceral Omentum | GGCX | 0.13 | 0.03 | lasso | 7 | 0.03 | 1.1e-02 | 5.6 | 5.5 | 4.1e-08 | 0.68 | 0.30 | 0.32 | FALSE |
4 | GTEx | Artery Aorta | GGCX | 0.23 | 0.22 | lasso | 6 | 0.23 | 5.5e-13 | 5.6 | 6.2 | 5.3e-10 | 0.74 | 0.72 | 0.28 | FALSE |
5 | GTEx | Artery Tibial | GGCX | 0.29 | 0.22 | enet | 14 | 0.24 | 6.3e-19 | 5.6 | 6.6 | 3.9e-11 | 0.69 | 0.84 | 0.16 | FALSE |
6 | GTEx | Brain Cerebellar Hemisphere | GGCX | 0.46 | 0.41 | enet | 16 | 0.48 | 5.3e-14 | 4.4 | 5.5 | 2.9e-08 | 0.72 | 0.86 | 0.14 | FALSE |
7 | GTEx | Brain Cerebellum | GGCX | 0.54 | 0.30 | lasso | 10 | 0.34 | 6.0e-11 | 5.5 | 6.3 | 3.5e-10 | 0.75 | 0.84 | 0.16 | FALSE |
8 | GTEx | Brain Cortex | GGCX | 0.38 | 0.17 | enet | 30 | 0.02 | 1.1e-01 | 4.4 | 5.2 | 1.5e-07 | 0.60 | 0.44 | 0.23 | FALSE |
9 | GTEx | Breast Mammary Tissue | GGCX | 0.14 | 0.01 | lasso | 3 | 0.01 | 1.0e-01 | 5.5 | 5.3 | 1.3e-07 | 0.69 | 0.13 | 0.12 | FALSE |
10 | GTEx | Breast Mammary Tissue (Male) | GGCX | 0.10 | 0.00 | enet | 4 | 0.00 | 3.3e-01 | 4.0 | 5.3 | 1.0e-07 | 0.69 | 0.06 | 0.09 | FALSE |
11 | GTEx | Cells EBV-transformed lymphocytes | GGCX | 0.36 | 0.31 | enet | 18 | 0.29 | 4.5e-10 | 4.3 | 5.4 | 5.5e-08 | 0.71 | 0.82 | 0.18 | FALSE |
12 | GTEx | Colon Transverse | GGCX | 0.26 | 0.28 | lasso | 3 | 0.28 | 1.4e-13 | 5.5 | 6.1 | 1.2e-09 | 0.73 | 0.79 | 0.21 | FALSE |
13 | GTEx | Esophagus Gastroesophageal Junction | GGCX | 0.24 | 0.16 | lasso | 6 | 0.12 | 4.3e-05 | 5.6 | 5.9 | 3.7e-09 | 0.74 | 0.34 | 0.44 | FALSE |
14 | GTEx | Esophagus Mucosa | GGCX | 0.29 | 0.21 | enet | 30 | 0.27 | 5.8e-18 | 5.9 | 5.6 | 1.9e-08 | 0.62 | 0.71 | 0.29 | FALSE |
15 | GTEx | Esophagus Mucosa | TMEM150A | 0.10 | 0.05 | enet | 5 | 0.05 | 3.2e-04 | 5.5 | -5.6 | 1.9e-08 | -0.80 | 0.07 | 0.88 | FALSE |
16 | GTEx | Esophagus Muscularis | GGCX | 0.14 | 0.12 | lasso | 9 | 0.12 | 1.1e-07 | 5.6 | 6.3 | 2.4e-10 | 0.75 | 0.52 | 0.48 | FALSE |
17 | GTEx | Lung | GGCX | 0.17 | 0.17 | lasso | 2 | 0.18 | 2.3e-13 | 5.6 | 5.6 | 2.3e-08 | 0.72 | 0.88 | 0.12 | FALSE |
18 | GTEx | Muscle Skeletal | GGCX | 0.10 | 0.04 | enet | 11 | 0.02 | 2.7e-03 | 5.6 | 6.3 | 3.0e-10 | 0.78 | 0.09 | 0.91 | FALSE |
19 | GTEx | Nerve Tibial | GGCX | 0.38 | 0.30 | lasso | 7 | 0.33 | 6.5e-24 | 5.6 | 6.5 | 6.5e-11 | 0.72 | 0.87 | 0.13 | FALSE |
20 | GTEx | Pancreas | VAMP5 | 0.29 | 0.09 | enet | 4 | 0.05 | 3.2e-03 | 6.3 | -6.9 | 4.8e-12 | -0.66 | 0.02 | 0.77 | FALSE |
21 | GTEx | Skin Not Sun Exposed Suprapubic | GGCX | 0.13 | 0.04 | enet | 11 | 0.06 | 3.9e-04 | 5.5 | 6.7 | 2.7e-11 | 0.64 | 0.30 | 0.24 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | GGCX | 0.15 | 0.11 | lasso | 3 | 0.18 | 7.9e-15 | 5.5 | 6.8 | 1.1e-11 | 0.69 | 0.72 | 0.28 | FALSE |
23 | GTEx | Testis | GGCX | 0.38 | 0.36 | enet | 25 | 0.40 | 8.6e-19 | 5.6 | 6.3 | 3.2e-10 | 0.72 | 0.76 | 0.24 | FALSE |
24 | GTEx | Thyroid | GGCX | 0.30 | 0.17 | enet | 10 | 0.23 | 1.4e-17 | 5.5 | 6.4 | 1.2e-10 | 0.74 | 0.83 | 0.17 | FALSE |
25 | GTEx | Whole Blood | GGCX | 0.15 | 0.14 | lasso | 4 | 0.15 | 1.7e-13 | 5.5 | 5.9 | 4.6e-09 | 0.73 | 0.85 | 0.15 | FALSE |
26 | NTR | Blood | VAMP5 | 0.04 | 0.01 | enet | 17 | 0.02 | 5.1e-08 | 6.1 | -5.3 | 9.3e-08 | -0.33 | 0.17 | 0.78 | FALSE |
27 | NTR | Blood | VAMP8 | 0.05 | 0.04 | lasso | 8 | 0.04 | 2.0e-12 | 5.4 | -5.4 | 5.2e-08 | -0.74 | 0.84 | 0.16 | FALSE |
28 | YFS | Blood | VAMP8 | 0.15 | 0.15 | enet | 37 | 0.18 | 2.2e-55 | 5.9 | -6.2 | 4.9e-10 | -0.75 | 0.74 | 0.26 | FALSE |
29 | The Cancer Genome Atlas | Colon Adenocarcinoma | C2orf68 | 0.06 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | 5.4 | -5.4 | 6.1e-08 | -0.88 | 0.02 | 0.67 | FALSE |
30 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GGCX | 0.05 | 0.05 | lasso | 1 | 0.04 | 1.2e-05 | 5.6 | 5.6 | 2.1e-08 | 0.72 | 0.64 | 0.23 | FALSE |
31 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | VAMP5 | 0.07 | 0.04 | blup | 44 | 0.05 | 2.1e-06 | 6.3 | -5.2 | 2.5e-07 | -0.49 | 0.12 | 0.78 | FALSE |
32 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | VAMP8 | 0.06 | 0.01 | enet | 15 | 0.02 | 2.1e-02 | 6.2 | 6.0 | 1.7e-09 | 0.45 | 0.04 | 0.25 | FALSE |
33 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GGCX | 0.04 | 0.02 | blup | 44 | 0.02 | 2.7e-03 | 6.1 | 7.4 | 1.2e-13 | 0.72 | 0.10 | 0.72 | TRUE |
34 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GGCX | 0.04 | 0.03 | lasso | 2 | 0.03 | 1.1e-02 | 5.9 | 5.9 | 4.2e-09 | 0.70 | 0.06 | 0.07 | FALSE |
35 | The Cancer Genome Atlas | Thyroid Carcinoma | GGCX | 0.03 | 0.03 | enet | 5 | 0.02 | 8.7e-03 | 5.1 | 5.6 | 2.0e-08 | 0.82 | 0.05 | 0.54 | FALSE |
36 | The Cancer Genome Atlas | Thyroid Carcinoma | VAMP8 | 0.04 | 0.05 | lasso | 3 | 0.05 | 1.2e-05 | 5.6 | -5.2 | 1.9e-07 | -0.77 | 0.34 | 0.51 | FALSE |