TWAS hub - RNF181

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0700	0.0240	0.00062	0.021	0.026	0.007	0.026	0.007	1.2e-03	3.6e-04	3.7e-02	3.4e-04	4.3e-02
2	YFS	Blood	0.1987	0.0274	0.00000	0.190	0.181	0.191	0.196	0.195	4.3e-60	5.5e-57	2.3e-60	4.4e-62	1.4e-61
3	TCGA	Lung Adenocarcinoma	0.0326	0.0207	0.00940	0.004	0.011	0.007	NA	0.003	1.1e-01	1.5e-02	4.3e-02	NA	1.3e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Prostate Cancer	7.3	10.3	14.9	-2.4	3.9	3.2
Illnesses of father: Heart disease	6.2	8.6	12.9	3.6	0.3	-3.6
Coronary Artery Disease (CAD)	6.0	7.2	16.0	2.0	1.2	-4.0
Medication for cholesterol	4.6	7.0	12.1	3.5	1.6	-2.5
Angina	4.2	5.5	13.9	1.3	-1.0	-3.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.8	4.4	8.1	-2.8	0.3	2.2
Angina (self-reported)	3.7	4.9	12.3	1.3	-0.8	-3.5
Arm fat-free mass (right)	3.4	17.3	32.4	5.7	3.2	-3.0
Alcohol drinker status: Previous	3.4	3.9	6.7	-2.6	0.9	2.1
Trunk predicted mass	3.2	18.2	32.6	5.7	3.2	-3.4
Trunk fat-free mass	3.1	18.0	32.4	5.7	3.1	-3.4
Arm predicted mass (right)	3.1	15.7	28.9	5.4	2.9	-3.1
Whole body water mass	3.1	17.5	30.7	5.5	3.1	-3.5
Basal metabolic rate	3.1	17.4	31.0	5.6	2.9	-3.5
Arm predicted mass (left)	3.1	15.6	28.8	5.4	3.0	-3.0
Hand grip strength (right)	3.0	8.3	16.9	4.1	2.0	-2.0
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	6.3	-2.5	-1.0	1.5
Whole body fat-free mass	3.0	17.3	30.1	5.5	3.1	-3.5
Arm fat-free mass (left)	2.9	14.8	27.9	5.3	2.8	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.5	14.8	-2.1	-0.4	3.9
Type 2 Diabetes (T2D) (2018)	2.7	5.0	10.2	-1.6	-1.5	3.2
Leg fat-free mass (right)	2.7	14.7	23.7	4.9	2.8	-3.5
Leg predicted mass (right)	2.7	14.5	23.1	4.8	2.9	-3.5
Ever used hormone-replacement therapy (HRT)	2.6	3.3	7.3	-2.7	-0.8	1.4
Leg predicted mass (left)	2.6	13.8	21.7	4.7	2.8	-3.5
Diabetes (self-reported)	2.6	4.0	5.3	-2.2	-1.3	2.3
Hip circumference	2.6	11.2	19.5	4.4	2.0	-3.2
Leg fat-free mass (left)	2.5	13.4	21.0	4.6	2.7	-3.4
Pulse rate, automated reading	2.4	7.7	16.0	-2.5	-0.9	4.0
Medication: Gliclazide	2.4	2.7	6.7	-0.0	-2.6	1.2
Hand grip strength (left)	2.3	6.1	11.7	3.4	1.7	-1.9
Weight	2.3	11.5	20.0	4.5	2.0	-3.2
Heart attack/myocardial infarction (self-reported)	2.3	2.9	6.0	1.3	-1.1	-2.4
Blood Eosinophil Count	2.2	17.2	38.2	-3.6	-0.6	6.2
Exposure to tobacco smoke outside home	2.2	2.9	3.2	1.8	-1.6	1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	10.8	3.3	0.9	-1.5
Age at First Birth	2.1	3.1	4.5	-2.1	-0.7	2.1
Heart attack	2.1	2.7	5.5	1.4	-0.8	-2.4
Standing height	2.1	21.1	37.6	6.1	2.4	-4.5
Average weekly red wine intake	2.1	3.1	7.4	-2.7	-0.8	1.1
Ever had prostate specific antigen (PSA) test	2.1	2.4	3.7	-0.1	-1.9	-1.9
LDL Cholesterol	2.0	3.1	7.3	-1.2	-0.7	2.7
Height	2.0	37.9	64.2	8.0	2.3	-6.7
Hearing difficulty/problems with background noise	2.0	3.2	5.3	-2.0	-2.3	0.5
Pain all over the body in last month	2.0	2.1	2.3	1.5	1.4	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	3.2	1.4	1.4	-1.8
Cholesterol lowering medication	2.0	3.0	8.1	-2.9	-0.8	0.5
Bipolar Disorder (2011)	1.9	1.8	4.7	-2.2	0.8	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	2.9	-1.7	-1.5	1.3
Loud music exposure frequency	1.9	2.1	3.4	-1.2	-1.2	1.9
Comparative height size at age 10	1.9	10.5	18.5	4.3	1.9	-3.1
Illnesses of siblings: Diabetes	1.9	2.4	3.8	1.4	-1.9	-1.1
Ever had bowel cancer screening	1.9	2.2	5.7	-2.4	0.3	0.9
Diabetes diagnosed by doctor	1.9	3.2	5.5	-1.7	-1.1	2.3
Heart disease (siblings)	1.9	2.4	4.8	2.2	-0.1	-1.5
Financial difficulties in last 2 years	1.8	2.4	5.9	2.4	0.1	-1.1
Mouth/teeth dental problems	1.8	2.8	4.8	0.5	1.8	-2.2
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.9	-1.7	2.4	0.0
Medication: Blood pressure	1.8	3.4	7.3	-2.7	-1.4	1.0
Age started oral contraceptive pill	1.8	2.3	3.2	-1.8	-0.8	-1.7
Blood Platelet Count	1.7	20.0	32.9	-2.6	-5.7	4.5
Had menopause	1.7	2.1	2.9	-1.2	1.7	-1.4
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.9	-1.2	-2.2	0.6
Blood White Count	1.6	12.1	30.6	-1.3	-2.0	5.5
Medication for hormone replacement therapy	1.6	1.8	4.4	-0.8	0.6	2.1
Qualifications: CSEs or equivalent	1.6	2.1	5.2	2.3	0.7	-0.7
Medication: Ramipril	1.6	2.0	2.7	-1.4	-1.6	1.2
Number of self-reported non-cancer illnesses	1.6	2.7	6.9	-2.6	-1.0	-0.6
Average weekly champagne plus white wine intake	1.6	2.2	3.2	-1.8	1.7	0.8
Supplements: Calcium	1.6	1.8	2.7	-0.7	1.7	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	7.2	-1.7	0.7	2.7
Sitting height	1.5	10.4	17.6	4.2	3.4	-1.5
Illnesses of siblings	1.5	2.1	2.7	-1.6	1.6	1.0
Blood clot in the leg (DVT)	1.5	1.9	3.8	-0.6	1.2	2.0
Heel T-Score	1.4	10.8	20.2	-4.5	-0.7	3.4
Average weekly spirits intake	1.4	1.8	3.7	1.9	-0.9	-0.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.5	-0.7	-1.3	1.6
Average weekly fortified wine intake	1.4	1.6	2.8	-1.0	-1.7	1.1
Taking other prescription medications	1.4	2.1	4.0	-2.0	0.4	-1.4
Medication: Levothyroxine sodium	1.4	2.4	3.8	-1.9	0.9	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.8	-1.4	0.2	1.7
Supplements: Fish oil (including cod liver oil)	1.4	1.9	3.6	-1.9	1.3	-0.7
High cholesterol (Self-reported)	1.4	2.5	5.5	-2.4	-1.1	0.9
Ovarian Cancer	1.3	1.7	3.3	1.8	0.3	-1.3
Father’s age at death	1.3	1.7	4.7	-2.2	-0.2	0.6
Number of live births	1.3	1.8	3.8	1.1	2.0	-0.6
Pulse wave Arterial Stiffness index	1.3	1.5	2.4	-1.2	1.6	0.8
Pulse wave peak to peak time	1.3	1.5	2.3	1.5	-1.2	-0.9
Heart disease (mother)	1.3	1.6	2.6	1.5	-0.1	-1.6
Smoking status: Previous	1.3	1.9	4.7	1.0	0.1	-2.2
Commuting to job workplace: Walk	1.3	1.4	3.6	0.8	-1.9	-0.4
Medication: Lisinopril	1.3	1.6	2.3	-1.3	-1.5	1.0
Severe depression (siblings)	1.2	1.4	3.1	-0.7	-0.7	1.8
Medication: Simvastatin	1.2	1.8	3.7	-1.9	-1.1	0.7
Alcohol intake versus 10 years previously	1.2	1.8	3.3	-0.6	-1.8	1.3
Depression (self-reported)	1.2	1.4	3.2	-0.4	0.9	-1.8
Lung cancer (father)	1.2	1.4	2.0	-1.1	0.9	1.4
Tense / ‘highly strung’	1.2	1.9	3.0	-0.9	-1.4	1.7
Age at first live birth	1.2	2.2	5.7	-2.4	0.8	0.5
Health satisfaction	1.2	1.6	4.2	-2.0	-0.6	0.5
Commuting to job workplace: Car/motor vehicle	1.2	1.4	1.9	-0.7	1.4	1.3
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.1	0.8	1.2	-1.4
Ever depressed for a whole week	1.2	1.4	4.2	-0.1	-0.4	2.0
Alzheimer’s Disease (in father)	1.1	1.2	2.7	-0.3	0.9	-1.6
Cardiovascular Disease	1.1	3.6	5.1	-2.0	-2.3	1.3
Number of treatments/medications taken	1.1	2.1	3.7	-1.0	-1.9	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	2.0	-1.4	-1.2	1.4
Pulse rate	1.1	1.8	2.6	-1.3	-1.0	1.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.2	0.8	-1.5	1.1
Age at last live birth	1.1	1.7	2.9	-1.4	1.7	0.5
Leg pain on walking	1.1	1.4	2.3	-0.4	1.3	-1.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.0	-1.7	-0.7	0.8
Loneliness, isolation	1.1	1.5	2.9	1.0	0.7	-1.7
Osteoporosis (self-reported)	1.1	1.4	2.4	-0.8	1.5	1.1
Commuting to job workplace: Public transport	1.1	1.3	3.5	-0.6	-1.9	0.4
Intelligence (Savage-Jansen 2018)	1.0	2.9	6.5	-2.5	0.3	1.5
Maternal smoking around birth	1.0	1.4	2.3	1.5	0.6	-1.3
Relative age voice broke	1.0	1.5	2.3	-0.8	-1.3	1.5
High blood pressure (mother)	1.0	1.4	2.4	-0.0	1.3	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	6.8	2.6	0.9	-1.3
Birth weight	1.0	2.3	6.1	2.5	0.7	-0.4
Ever taken oral contraceptive pill	1.0	1.1	1.7	-0.9	0.9	1.3
Number of operations (self-reported)	1.0	1.5	2.6	1.3	-0.2	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.6	-0.4	1.0	1.6
Verbal and Numeric Reasoning (VNR)	0.9	2.1	6.1	-2.5	0.2	0.2
Neuroticism (2016)	0.9	1.3	2.1	0.9	-1.0	-1.4
Medication: Metformin	0.9	1.3	3.2	-1.8	-0.8	0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.5	-1.0	0.0	1.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.8	-1.2	-0.6	1.4
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.7	-0.3	1.6	-0.9
Chest pain or discomfort	0.9	1.2	2.1	-1.1	-1.4	0.7
Long-standing illness, disability or infirmity	0.9	1.4	2.4	-1.3	-0.1	-1.6
Eye problems/disorders: Cataract	0.9	1.0	1.1	-1.1	0.9	1.1
Body Mass Index (BMI) (2010)	0.8	1.0	1.5	0.6	1.1	-1.2
HbA1C	0.8	0.9	1.7	-0.1	-1.0	1.3
Waist Hip Ratio (WHR)	0.8	3.4	6.1	-1.8	-1.0	2.5
Hypothyroidism (self reported)	0.8	1.8	2.7	-1.6	0.5	-1.5
Lung FEV1/FVC ratio	0.8	4.0	5.1	2.3	-1.9	-1.8
Serious illness, injury or assault to yourself	0.8	0.9	2.3	0.6	0.2	1.5
Trunk fat mass	0.8	3.6	6.7	2.6	0.5	-1.9
Past tobacco smoking	0.8	1.4	3.6	-0.8	0.1	1.9
Hair/balding pattern: Pattern 2	0.8	1.1	1.6	1.3	1.0	-0.8
Impedance of arm (right)	0.8	3.7	6.5	-2.2	-2.5	-0.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	6.9	2.6	0.3	-1.2
Arm fat mass (right)	0.8	3.4	6.2	2.5	0.8	-1.8
Forced vital capacity (FVC), Best measure	0.8	2.9	5.6	2.4	1.3	-1.2
Number of full brothers	0.8	1.1	2.1	1.0	1.5	0.1
Shortness of breath walking on level ground	0.8	0.9	1.4	-1.2	0.6	-0.9
Whole body fat mass	0.8	3.5	6.2	2.5	1.1	-1.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.1	-0.5	-1.2	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.2	1.5	0.8	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.4	-1.8	0.6	1.1
Arm fat mass (left)	0.8	3.2	5.7	2.4	0.7	-1.9
Risk taking	0.8	1.2	2.6	0.6	0.8	1.6
Fractured/broken bones in last 5 years	0.8	1.0	2.0	0.7	1.4	0.7
Leg fat mass (left)	0.8	3.2	6.2	2.5	1.1	-1.5
Bipolar Disorder (2018)	0.7	1.0	1.9	-1.0	1.4	-0.4
Schizophrenia (2018)	0.7	1.5	3.1	0.1	-1.1	-1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	1.1	-0.9	-1.0	1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	1.9	-0.7	1.4	-0.8
Respiratory disease	0.7	1.5	2.5	-1.4	-0.3	1.6
Relative age of first facial hair	0.7	1.4	3.3	-0.6	-1.8	0.8
Vitamin and mineral supplements	0.7	0.9	1.5	-1.2	-1.0	0.5
Diabetes (mother)	0.7	0.9	1.4	0.7	-1.0	1.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.5	0.2	-1.2	0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.2	0.5	0.2	-1.5
Medication: Atenolol	0.7	0.9	2.6	-0.4	-0.1	-1.6
Waist circumference	0.7	2.5	5.8	2.4	0.6	-1.1
Number of incorrect matches in round	0.7	1.2	1.5	0.8	-1.2	-1.2
Forced vital capacity (FVC)	0.7	2.6	5.9	2.4	0.9	-1.1
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.5	-1.6	1.1	0.9
Impedance of arm (left)	0.7	3.1	4.7	-2.2	-2.1	-0.0
Headache pain in last month	0.7	1.2	3.6	-0.3	-0.0	1.9
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.9	-1.1	0.4	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	0.8	0.7	-1.3
Neck or shoulder pain in last month	0.7	1.0	3.0	-0.1	0.3	1.7
Leg fat mass (right)	0.7	2.9	5.8	2.4	0.8	-1.5
Had major operations	0.7	0.8	1.2	0.6	-0.9	-1.1
Medication: Aspirin	0.7	1.0	1.5	-0.8	-1.2	-0.9
Wears glasses or contact lenses	0.7	0.8	1.8	-0.8	0.0	-1.3
Ever smoked	0.7	1.2	3.5	0.3	-0.2	-1.9
Impedance of whole body	0.7	3.3	5.9	-1.7	-2.4	1.1
Major Depression (MDD)	0.6	0.7	1.2	-0.6	0.7	-1.1
Rheumatoid Arthritis	0.6	0.8	2.0	0.5	1.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	-0.4	-1.2	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.2	-0.5	0.8	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.9	2.0	1.4	-0.7	0.0
High blood pressure	0.6	1.6	4.2	-0.6	-2.1	0.3
Stomach or abdominal pain in last month	0.6	0.7	1.2	-0.4	1.1	0.9
Alcohol usually taken with meals	0.6	1.0	2.9	-1.7	-0.1	0.2
Medication: Paracetamol	0.6	1.1	1.9	1.4	0.7	-0.9
Glaucoma (self-reported)	0.6	0.6	1.9	-1.4	0.2	-0.1
Worry too long after embarrassment	0.6	1.0	2.5	-0.6	-1.6	0.3
Medication: Aspirin	0.6	0.8	1.5	-0.4	-1.2	-0.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	-1.4	-0.3	-0.5
Mood swings	0.6	1.0	2.2	1.5	0.4	-0.8
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	0.0	0.8	1.2
Commuting to job workplace: Cycle	0.6	0.8	2.2	-0.2	-0.3	-1.5
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.3	0.3	2.1	0.8
Schizophrenia (2014)	0.5	1.1	3.3	-0.0	-0.4	-1.8
Systolic Blood Pressure	0.5	2.3	6.1	-2.5	-0.9	0.4
Impedance of leg (right)	0.5	2.4	4.6	-0.9	-2.1	1.3
Townsend deprivation index at recruitment	0.5	0.7	1.6	-0.3	0.7	-1.3
Current tobacco smoking	0.5	0.8	1.7	1.3	-0.4	0.6
Supplements: Glucosamine	0.5	0.6	1.1	-1.1	0.8	-0.3
Body mass index (BMI)	0.5	2.0	3.6	1.9	0.9	-1.2
Exposure to tobacco smoke at home	0.5	0.5	1.3	1.1	0.3	-0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	-0.7	0.1	1.1
Comparative body size at age 10	0.5	1.3	2.4	1.0	0.7	-1.5
Number of children fathered	0.5	0.6	0.9	0.2	0.9	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	1.0	-0.9	0.1
Friendships satisfaction	0.5	0.6	1.2	0.8	1.1	-0.2
Guilty feelings	0.5	0.8	1.4	1.2	0.3	-1.0
Alcohol drinker status: Never	0.5	0.6	1.5	1.2	-0.2	-0.7
Myopia	0.5	0.7	1.9	-1.4	0.3	-0.2
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	-0.6	-0.0	-1.6
Crohns Disease (2017)	0.4	0.9	2.7	0.3	0.1	-1.6
Mean Putamen Volume	0.4	0.4	0.8	-0.9	-0.2	0.7
Fasting Glucose	0.4	0.4	1.2	-0.1	-0.3	1.1
Triglycerides	0.4	0.7	1.4	1.2	-0.6	0.6
Blood Red Count	0.4	4.3	7.0	2.0	-1.4	2.6
Neuroticism	0.4	0.9	1.5	-1.2	-0.2	1.1
Systolic blood pressure, automated reading	0.4	1.2	2.5	-1.6	-1.0	0.5
Pack years adult smoking proportion	0.4	0.5	1.3	1.1	0.5	0.3
Impedance of leg (left)	0.4	2.0	4.1	-0.5	-2.0	1.3
Nervous feelings	0.4	0.7	1.9	-1.4	0.3	0.5
Fluid intelligence score	0.4	0.9	2.3	-1.5	-0.3	0.5
Time employed in main current job	0.4	0.5	0.9	0.6	0.9	-0.6
Noisy workplace	0.4	0.6	1.3	-0.5	1.1	-0.3
Mouth/teeth dental problems: Dentures	0.4	0.6	1.2	1.1	-0.6	-0.6
Illnesses of mother	0.4	0.5	1.0	-0.7	-0.2	1.0
Medication: Amlodipine	0.4	0.6	0.9	-0.9	0.1	-0.9
Wheeze or whistling in the chest in last year	0.4	0.8	1.4	-0.5	-0.8	1.2
Medication: Ibuprofen	0.4	0.4	0.6	-0.2	-0.8	0.8
Medication: Omeprazole	0.4	0.4	0.7	-0.8	-0.1	0.8
Mean time to correctly identify matches	0.4	0.8	1.2	-1.0	-1.1	-0.5
Alcohol intake frequency.	0.4	0.9	1.6	0.2	1.2	1.0
Number of full sisters	0.4	0.5	1.0	-0.3	-0.6	1.0
Family relationship satisfaction	0.4	0.5	1.0	-0.7	0.4	1.0
Hypertension (Self-reported)	0.4	1.2	2.8	-0.7	-1.7	0.6
Back pain experienced in last month	0.4	0.6	1.0	0.1	0.9	-1.0
Mineral and other dietary supplements	0.4	0.6	1.6	1.2	-0.4	-0.1
Osteoarthritis (self-reported)	0.4	0.5	1.2	-1.1	-0.2	-0.3
Average weekly beer plus cider intake	0.4	0.6	1.7	1.3	-0.3	-0.2
Neuroticism (Nagel 2018)	0.3	0.6	1.6	-1.3	0.3	0.4
Worry (Nagel 2018)	0.3	0.6	1.4	-1.2	-0.4	0.6
BMI	0.3	1.5	2.5	1.6	1.3	-0.5
Allergy or Eczema	0.3	0.8	1.7	-1.3	-0.8	0.4
Sensitivity / hurt feelings	0.3	0.5	0.7	0.7	0.5	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.8	0.0	-0.7
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.8	0.5	-0.4
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-0.4	-1.1	0.7
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	0.7	-0.6	0.3
Qualifications: None of the above	0.3	0.6	1.6	0.4	-1.3	0.1
Allergy	0.3	0.6	1.3	0.7	-0.0	-1.1
Worrier / anxious feelings	0.3	0.6	1.1	0.7	0.2	-1.1
Happiness	0.3	0.4	1.1	0.0	1.1	0.3
Medication: Lansoprazole	0.3	0.4	0.8	-0.9	0.5	-0.4
Prospective memory result	0.3	0.3	0.8	0.3	0.9	0.1
Length of working week for main job	0.3	0.4	0.9	0.3	0.9	0.5
Peak expiratory flow (PEF)	0.3	0.6	0.9	0.8	1.0	0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	1.0	0.4	-0.4
Qualifications: College or University degree	0.3	0.9	1.3	-0.7	-1.0	1.1
Eye problems/disorders: None of the above	0.3	0.3	0.7	-0.2	-0.5	-0.8
Medication: Seretide 50 evohaler	0.3	0.4	0.6	0.7	-0.1	0.8
Breast cancer (self-reported)	0.3	0.3	0.8	0.3	-0.1	-0.9
Smoking status: Current	0.3	0.5	1.0	1.0	-0.1	0.7
Hearing aid user	0.3	0.4	0.9	0.3	1.0	-0.4
Financial situation satisfaction	0.3	0.3	0.7	0.6	-0.8	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.5	0.2	-1.0
Medication: Bendroflumethiazide	0.3	0.5	0.7	0.7	-0.9	0.5
Illnesses of father: High blood pressure	0.3	0.3	0.5	-0.7	-0.7	-0.2
Irritability	0.3	0.4	0.5	-0.7	-0.6	0.6
Unable to work because of sickness or disability	0.3	0.4	1.0	0.2	1.0	0.3
Depressed Affect (Nagel 2018)	0.2	0.3	0.8	-0.9	0.4	0.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	0.6	-0.3	-1.1
Ulcerative Colitis (UC)	0.2	0.4	0.6	0.6	-0.5	-0.8
Reaction Time	0.2	0.4	0.7	-0.8	-0.8	0.0
Crohns Disease (2012)	0.2	0.3	0.4	0.2	0.5	-0.6
Lupus	0.2	0.3	0.7	0.3	0.2	0.8
Chronotype (morning person)	0.2	0.6	1.5	-0.2	-1.2	0.3
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.1	-0.9	0.1
Supplements: Zinc	0.2	0.3	0.3	-0.5	-0.5	0.5
Medication: Co-codamol	0.2	0.2	0.3	0.5	-0.5	0.2
Trunk fat percentage	0.2	0.9	1.4	1.1	-0.5	-1.2
Fed-up feelings	0.2	0.4	1.0	0.4	-1.0	0.3
Age when periods started (menarche)	0.2	0.6	1.4	1.2	0.4	0.4
Multivitamins +/- minerals	0.2	0.3	0.6	0.8	-0.1	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.4	-0.1	-0.8
Had other major operations	0.2	0.3	0.3	-0.5	0.5	-0.5
Falls in the last year	0.2	0.2	0.6	0.1	-0.8	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.5	-0.4	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.3	-0.6	0.5
Breastfed as a baby	0.2	0.3	0.5	-0.7	-0.5	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.4	-0.6	-0.7
Hair/balding pattern: Pattern 4	0.2	0.5	0.7	0.1	-0.8	0.8
Pulse wave reflection index	0.2	0.3	0.6	-0.1	0.8	0.4
High blood pressure (siblings)	0.2	0.3	0.7	-0.0	-0.8	-0.5
Body fat percentage	0.2	0.6	0.9	0.9	-0.4	-0.9
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.7	-0.3	0.1
Medication: Allopurinol	0.2	0.3	0.7	-0.3	-0.2	0.9
Suffer from ‘nerves’	0.2	0.3	0.7	-0.8	-0.2	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.4	0.1	0.6	0.6
Miserableness	0.2	0.4	1.0	-1.0	0.6	-0.0
Mother’s age at death	0.2	0.2	0.5	-0.4	-0.1	-0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.7	0.1	-0.2
Medication: Paracetamol	0.2	0.3	0.9	1.0	0.2	0.2
Diastolic blood pressure, automated reading	0.2	0.5	1.2	-0.6	-0.0	1.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.7	-0.2	-0.5
Pain experienced in last month	0.2	0.3	0.5	-0.7	0.3	-0.6
Pack years of smoking	0.2	0.3	0.4	0.6	0.7	0.1
Depression (Nagel 2018)	0.1	0.2	0.2	0.5	0.4	-0.3
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.1	-0.1	0.4
Breast Cancer	0.1	0.2	0.7	-0.2	-0.8	-0.0
HDL Cholesterol	0.1	0.2	0.3	-0.3	0.5	-0.6
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.6	-0.5	0.0
Smoking Status	0.1	0.2	0.5	0.7	0.3	-0.3
Lung FVC	0.1	0.4	0.9	-0.9	-0.5	0.2
Hair Pigment	0.1	2.4	3.4	1.8	-0.8	-1.9
Tanning	0.1	1.7	4.7	-0.5	0.3	2.2
Diabetes (father)	0.1	0.1	0.4	0.6	0.2	0.0
Neuroticism score	0.1	0.2	0.5	0.2	-0.7	0.4
Arm fat percentage (right)	0.1	0.3	0.6	0.6	-0.3	-0.8
Medication: Cholesterol lowering	0.1	0.1	0.4	-0.2	-0.1	0.6
Birth weight of first child	0.1	0.1	0.3	-0.2	0.5	0.0
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.3	0.2	-0.5
Gout (self-reported)	0.1	0.1	0.1	-0.3	0.3	0.4
Leg fat percentage (right)	0.1	0.4	0.5	0.7	-0.5	-0.6
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.2	0.7	0.0
Medication: Blood pressure	0.1	0.1	0.2	0.5	0.3	0.2
Overall health rating	0.1	0.3	0.6	0.8	-0.1	0.5
Supplements: Vitamin C	0.1	0.1	0.2	0.5	0.2	-0.3
Knee pain experienced in last month	0.1	0.1	0.2	0.0	-0.5	0.4
Arm fat percentage (left)	0.1	0.6	1.1	0.7	-0.3	-1.0
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.5	0.3	0.3
Asthma (self-reported)	0.1	0.1	0.2	-0.5	0.3	0.0
Medication: Atorvastatin	0.1	0.2	0.5	0.1	-0.1	0.7
Leg fat percentage (left)	0.1	0.4	0.8	0.9	-0.3	-0.6
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.5	-0.5	-0.1
Ulcerative Colitis	0.0	0.0	0.1	-0.3	0.0	0.1
Asthma	0.0	0.1	0.2	-0.2	0.5	-0.1
Migraine (self-reported)	0.0	0.1	0.1	0.3	-0.2	0.1

Hub : Genes

RNF181

Models

Trait associations