Hub : Genes

RNF181

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0700	0.0240	0.00062	0.021	0.026	0.007	0.026	0.007	1.2e-03	3.6e-04	3.7e-02	3.4e-04	4.3e-02
2	YFS	Blood	0.1987	0.0274	0.00000	0.190	0.181	0.191	0.196	0.195	4.3e-60	5.5e-57	2.3e-60	4.4e-62	1.4e-61
3	TCGA	Lung Adenocarcinoma	0.0326	0.0207	0.00940	0.004	0.011	0.007	NA	0.003	1.1e-01	1.5e-02	4.3e-02	NA	1.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.0	1.9	-1.0	1.4	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	-0.6	-0.0	-1.6
Depressed Affect (Nagel 2018)	0.2	0.3	0.8	-0.9	0.4	0.1
Depression (Nagel 2018)	0.1	0.2	0.2	0.5	0.4	-0.3
Intelligence (Savage-Jansen 2018)	1.0	2.9	6.5	-2.5	0.3	1.5
Neuroticism (Nagel 2018)	0.3	0.6	1.6	-1.3	0.3	0.4
Schizophrenia (2018)	0.7	1.5	3.1	0.1	-1.1	-1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	1.1	-0.9	-1.0	1.0
Worry (Nagel 2018)	0.3	0.6	1.4	-1.2	-0.4	0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.1	-0.1	0.4
Alzheimer’s Disease (in father)	1.1	1.2	2.7	-0.3	0.9	-1.6
Alzheimer’s Disease (including proxy)	0.7	1.0	1.9	-0.7	1.4	-0.8
Crohns Disease (2017)	0.4	0.9	2.7	0.3	0.1	-1.6
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	0.6	-0.3	-1.1
Ulcerative Colitis (UC)	0.2	0.4	0.6	0.6	-0.5	-0.8
Major Depression (MDD)	0.6	0.7	1.2	-0.6	0.7	-1.1
Reaction Time	0.2	0.4	0.7	-0.8	-0.8	0.0
Verbal and Numeric Reasoning (VNR)	0.9	2.1	6.1	-2.5	0.2	0.2
Breast Cancer	0.1	0.2	0.7	-0.2	-0.8	-0.0
Ovarian Cancer	1.3	1.7	3.3	1.8	0.3	-1.3
Prostate Cancer	7.3	10.3	14.9	-2.4	3.9	3.2
Age at First Birth	2.1	3.1	4.5	-2.1	-0.7	2.1
Bipolar Disorder (2011)	1.9	1.8	4.7	-2.2	0.8	-0.3
Body Mass Index (BMI) (2010)	0.8	1.0	1.5	0.6	1.1	-1.2
Coronary Artery Disease (CAD)	6.0	7.2	16.0	2.0	1.2	-4.0
Crohns Disease (2012)	0.2	0.3	0.4	0.2	0.5	-0.6
Mean Putamen Volume	0.4	0.4	0.8	-0.9	-0.2	0.7
Fasting Glucose	0.4	0.4	1.2	-0.1	-0.3	1.1
HbA1C	0.8	0.9	1.7	-0.1	-1.0	1.3
HDL Cholesterol	0.1	0.2	0.3	-0.3	0.5	-0.6
LDL Cholesterol	2.0	3.1	7.3	-1.2	-0.7	2.7
Lupus	0.2	0.3	0.7	0.3	0.2	0.8
Neuroticism (2016)	0.9	1.3	2.1	0.9	-1.0	-1.4
Primary Biliary Cirrhosis	0.1	0.2	0.4	-0.6	-0.5	0.0
Rheumatoid Arthritis	0.6	0.8	2.0	0.5	1.4	-0.4
Schizophrenia (2014)	0.5	1.1	3.3	-0.0	-0.4	-1.8
Triglycerides	0.4	0.7	1.4	1.2	-0.6	0.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	-0.4	-1.2	0.8
Ulcerative Colitis	0.0	0.0	0.1	-0.3	0.0	0.1
Blood Eosinophil Count	2.2	17.2	38.2	-3.6	-0.6	6.2
Blood Platelet Count	1.7	20.0	32.9	-2.6	-5.7	4.5
Blood Red Count	0.4	4.3	7.0	2.0	-1.4	2.6
Blood White Count	1.6	12.1	30.6	-1.3	-2.0	5.5
Heel T-Score	1.4	10.8	20.2	-4.5	-0.7	3.4
BMI	0.3	1.5	2.5	1.6	1.3	-0.5
Height	2.0	37.9	64.2	8.0	2.3	-6.7
Waist Hip Ratio (WHR)	0.8	3.4	6.1	-1.8	-1.0	2.5
Systolic Blood Pressure	0.5	2.3	6.1	-2.5	-0.9	0.4
Smoking Status	0.1	0.2	0.5	0.7	0.3	-0.3
Allergy or Eczema	0.3	0.8	1.7	-1.3	-0.8	0.4
Cardiovascular Disease	1.1	3.6	5.1	-2.0	-2.3	1.3
Hypothyroidism (self reported)	0.8	1.8	2.7	-1.6	0.5	-1.5
Respiratory disease	0.7	1.5	2.5	-1.4	-0.3	1.6
Type 2 Diabetes (T2D) (2018)	2.7	5.0	10.2	-1.6	-1.5	3.2
Lung FEV1/FVC ratio	0.8	4.0	5.1	2.3	-1.9	-1.8
Lung FVC	0.1	0.4	0.9	-0.9	-0.5	0.2
Neuroticism	0.4	0.9	1.5	-1.2	-0.2	1.1
Chronotype (morning person)	0.2	0.6	1.5	-0.2	-1.2	0.3
Hair Pigment	0.1	2.4	3.4	1.8	-0.8	-1.9
Tanning	0.1	1.7	4.7	-0.5	0.3	2.2
Hand grip strength (left)	2.3	6.1	11.7	3.4	1.7	-1.9
Number of treatments/medications taken	1.1	2.1	3.7	-1.0	-1.9	1.3
Average weekly spirits intake	1.4	1.8	3.7	1.9	-0.9	-0.8
Sensitivity / hurt feelings	0.3	0.5	0.7	0.7	0.5	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.7	0.8	0.0	-0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.1	-0.9	0.1
Relative age of first facial hair	0.7	1.4	3.3	-0.6	-1.8	0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.2	-0.5	0.8	-1.1
Ever used hormone-replacement therapy (HRT)	2.6	3.3	7.3	-2.7	-0.8	1.4
Ever had hysterectomy (womb removed)	0.3	0.4	0.7	0.8	0.5	-0.4
Systolic blood pressure, automated reading	0.4	1.2	2.5	-1.6	-1.0	0.5
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.5	-0.7	-1.3	1.6
Angina	4.2	5.5	13.9	1.3	-1.0	-3.7
Medication for hormone replacement therapy	1.6	1.8	4.4	-0.8	0.6	2.1
Vitamin and mineral supplements	0.7	0.9	1.5	-1.2	-1.0	0.5
Supplements: Zinc	0.2	0.3	0.3	-0.5	-0.5	0.5
Medication: Co-codamol	0.2	0.2	0.3	0.5	-0.5	0.2
Medication: Metformin	0.9	1.3	3.2	-1.8	-0.8	0.2
Diabetes (father)	0.1	0.1	0.4	0.6	0.2	0.0
Diabetes (mother)	0.7	0.9	1.4	0.7	-1.0	1.2
Severe depression (siblings)	1.2	1.4	3.1	-0.7	-0.7	1.8
Pack years adult smoking proportion	0.4	0.5	1.3	1.1	0.5	0.3
Impedance of leg (right)	0.5	2.4	4.6	-0.9	-2.1	1.3
Leg fat-free mass (left)	2.5	13.4	21.0	4.6	2.7	-3.4
Trunk fat percentage	0.2	0.9	1.4	1.1	-0.5	-1.2
Hand grip strength (right)	3.0	8.3	16.9	4.1	2.0	-2.0
Townsend deprivation index at recruitment	0.5	0.7	1.6	-0.3	0.7	-1.3
Current tobacco smoking	0.5	0.8	1.7	1.3	-0.4	0.6
Average weekly fortified wine intake	1.4	1.6	2.8	-1.0	-1.7	1.1
Maternal smoking around birth	1.0	1.4	2.3	1.5	0.6	-1.3
Fed-up feelings	0.2	0.4	1.0	0.4	-1.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.9	2.0	1.4	-0.7	0.0
Relative age voice broke	1.0	1.5	2.3	-0.8	-1.3	1.5
Taking other prescription medications	1.4	2.1	4.0	-2.0	0.4	-1.4
Age when periods started (menarche)	0.2	0.6	1.4	1.2	0.4	0.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.5	0.2	-1.2	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.5	7.2	-1.7	0.7	2.7
Tinnitus: Yes, but not now, but have in the past	3.0	3.2	6.3	-2.5	-1.0	1.5
Qualifications: CSEs or equivalent	1.6	2.1	5.2	2.3	0.7	-0.7
Serious illness, injury or assault to yourself	0.8	0.9	2.3	0.6	0.2	1.5
High blood pressure	0.6	1.6	4.2	-0.6	-2.1	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-0.4	-1.1	0.7
Multivitamins +/- minerals	0.2	0.3	0.6	0.8	-0.1	0.6
Stomach or abdominal pain in last month	0.6	0.7	1.2	-0.4	1.1	0.9
Supplements: Glucosamine	0.5	0.6	1.1	-1.1	0.8	-0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.2	0.5	0.2	-1.5
Medication: Atenolol	0.7	0.9	2.6	-0.4	-0.1	-1.6
Medication: Levothyroxine sodium	1.4	2.4	3.8	-1.9	0.9	-1.6
Sitting height	1.5	10.4	17.6	4.2	3.4	-1.5
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	0.7	-0.6	0.3
High blood pressure (mother)	1.0	1.4	2.4	-0.0	1.3	-1.6
Body mass index (BMI)	0.5	2.0	3.6	1.9	0.9	-1.2
Impedance of leg (left)	0.4	2.0	4.1	-0.5	-2.0	1.3
Leg predicted mass (left)	2.6	13.8	21.7	4.7	2.8	-3.5
Trunk fat mass	0.8	3.6	6.7	2.6	0.5	-1.9
Waist circumference	0.7	2.5	5.8	2.4	0.6	-1.1
Number of incorrect matches in round	0.7	1.2	1.5	0.8	-1.2	-1.2
Past tobacco smoking	0.8	1.4	3.6	-0.8	0.1	1.9
Alcohol usually taken with meals	0.6	1.0	2.9	-1.7	-0.1	0.2
Nervous feelings	0.4	0.7	1.9	-1.4	0.3	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.4	-0.1	-0.8
Hearing difficulty/problems with background noise	2.0	3.2	5.3	-2.0	-2.3	0.5
Hair/balding pattern: Pattern 2	0.8	1.1	1.6	1.3	1.0	-0.8
Had menopause	1.7	2.1	2.9	-1.2	1.7	-1.4
Had other major operations	0.2	0.3	0.3	-0.5	0.5	-0.5
Forced vital capacity (FVC)	0.7	2.6	5.9	2.4	0.9	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.5	14.8	-2.1	-0.4	3.9
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.5	-1.0	0.0	1.6
Qualifications: None of the above	0.3	0.6	1.6	0.4	-1.3	0.1
Financial difficulties in last 2 years	1.8	2.4	5.9	2.4	0.1	-1.1
Mouth/teeth dental problems	1.8	2.8	4.8	0.5	1.8	-2.2
Heart attack	2.1	2.7	5.5	1.4	-0.8	-2.4
Allergy	0.3	0.6	1.3	0.7	-0.0	-1.1
Pain all over the body in last month	2.0	2.1	2.3	1.5	1.4	-1.5
Diabetes (self-reported)	2.6	4.0	5.3	-2.2	-1.3	2.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.8	-1.2	-0.6	1.4
Medication: Ramipril	1.6	2.0	2.7	-1.4	-1.6	1.2
Medication: Simvastatin	1.2	1.8	3.7	-1.9	-1.1	0.7
Fluid intelligence score	0.4	0.9	2.3	-1.5	-0.3	0.5
Illnesses of siblings	1.5	2.1	2.7	-1.6	1.6	1.0
Neuroticism score	0.1	0.2	0.5	0.2	-0.7	0.4
Weight	2.3	11.5	20.0	4.5	2.0	-3.2
Impedance of arm (right)	0.8	3.7	6.5	-2.2	-2.5	-0.1
Arm fat percentage (right)	0.1	0.3	0.6	0.6	-0.3	-0.8
Trunk fat-free mass	3.1	18.0	32.4	5.7	3.1	-3.4
Hip circumference	2.6	11.2	19.5	4.4	2.0	-3.2
Time employed in main current job	0.4	0.5	0.9	0.6	0.9	-0.6
Alcohol intake versus 10 years previously	1.2	1.8	3.3	-0.6	-1.8	1.3
Father’s age at death	1.3	1.7	4.7	-2.2	-0.2	0.6
Worrier / anxious feelings	0.3	0.6	1.1	0.7	0.2	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	2.0	-1.4	-1.2	1.4
Falls in the last year	0.2	0.2	0.6	0.1	-0.8	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.5	-0.4	0.6
Number of live births	1.3	1.8	3.8	1.1	2.0	-0.6
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	6.9	2.6	0.3	-1.2
Pulse rate	1.1	1.8	2.6	-1.3	-1.0	1.6
Happiness	0.3	0.4	1.1	0.0	1.1	0.3
Noisy workplace	0.4	0.6	1.3	-0.5	1.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	2.5	-1.6	1.1	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	2.9	-1.7	-1.5	1.3
Mouth/teeth dental problems: Dentures	0.4	0.6	1.2	1.1	-0.6	-0.6
Asthma	0.0	0.1	0.2	-0.2	0.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.3	-0.6	0.5
Medication: Cholesterol lowering	0.1	0.1	0.4	-0.2	-0.1	0.6
Depression (self-reported)	1.2	1.4	3.2	-0.4	0.9	-1.8
Medication: Lansoprazole	0.3	0.4	0.8	-0.9	0.5	-0.4
Prospective memory result	0.3	0.3	0.8	0.3	0.9	0.1
Lung cancer (father)	1.2	1.4	2.0	-1.1	0.9	1.4
Illnesses of mother	0.4	0.5	1.0	-0.7	-0.2	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	6.8	2.6	0.9	-1.3
Pulse wave Arterial Stiffness index	1.3	1.5	2.4	-1.2	1.6	0.8
Impedance of arm (left)	0.7	3.1	4.7	-2.2	-2.1	-0.0
Arm fat mass (right)	0.8	3.4	6.2	2.5	0.8	-1.8
Trunk predicted mass	3.2	18.2	32.6	5.7	3.2	-3.4
Standing height	2.1	21.1	37.6	6.1	2.4	-4.5
Length of working week for main job	0.3	0.4	0.9	0.3	0.9	0.5
Exposure to tobacco smoke at home	0.5	0.5	1.3	1.1	0.3	-0.5
Breastfed as a baby	0.2	0.3	0.5	-0.7	-0.5	-0.2
Tense / ‘highly strung’	1.2	1.9	3.0	-0.9	-1.4	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.4	-0.6	-0.7
Hair/balding pattern: Pattern 4	0.2	0.5	0.7	0.1	-0.8	0.8
Birth weight of first child	0.1	0.1	0.3	-0.2	0.5	0.0
Peak expiratory flow (PEF)	0.3	0.6	0.9	0.8	1.0	0.5
Pulse wave reflection index	0.2	0.3	0.6	-0.1	0.8	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	1.0	0.4	-0.4
Loud music exposure frequency	1.9	2.1	3.4	-1.2	-1.2	1.9
Qualifications: O levels/GCSEs or equivalent	1.8	2.9	5.9	-1.7	2.4	0.0
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.9	-1.2	-2.2	0.6
Blood clot in the leg (DVT)	1.5	1.9	3.8	-0.6	1.2	2.0
Medication: Paracetamol	0.6	1.1	1.9	1.4	0.7	-0.9
Headache pain in last month	0.7	1.2	3.6	-0.3	-0.0	1.9
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.3	0.2	-0.5
Glaucoma (self-reported)	0.6	0.6	1.9	-1.4	0.2	-0.1
Gout (self-reported)	0.1	0.1	0.1	-0.3	0.3	0.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.9	-1.1	0.4	-1.7
Medication: Amlodipine	0.4	0.6	0.9	-0.9	0.1	-0.9
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.7	-0.3	1.6	-0.9
Birth weight	1.0	2.3	6.1	2.5	0.7	-0.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.2	-0.7	0.1	1.1
High blood pressure (siblings)	0.2	0.3	0.7	-0.0	-0.8	-0.5
Forced vital capacity (FVC), Best measure	0.8	2.9	5.6	2.4	1.3	-1.2
Body fat percentage	0.2	0.6	0.9	0.9	-0.4	-0.9
Leg fat percentage (right)	0.1	0.4	0.5	0.7	-0.5	-0.6
Arm fat-free mass (right)	3.4	17.3	32.4	5.7	3.2	-3.0
Exposure to tobacco smoke outside home	2.2	2.9	3.2	1.8	-1.6	1.8
Comparative body size at age 10	0.5	1.3	2.4	1.0	0.7	-1.5
Number of full brothers	0.8	1.1	2.1	1.0	1.5	0.1
Worry too long after embarrassment	0.6	1.0	2.5	-0.6	-1.6	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	0.8	0.7	-1.3
Wheeze or whistling in the chest in last year	0.4	0.8	1.4	-0.5	-0.8	1.2
Number of children fathered	0.5	0.6	0.9	0.2	0.9	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	2.8	-1.4	0.2	1.7
Age at first live birth	1.2	2.2	5.7	-2.4	0.8	0.5
Pulse wave peak to peak time	1.3	1.5	2.3	1.5	-1.2	-0.9
Health satisfaction	1.2	1.6	4.2	-2.0	-0.6	0.5
Shortness of breath walking on level ground	0.8	0.9	1.4	-1.2	0.6	-0.9
Qualifications: College or University degree	0.3	0.9	1.3	-0.7	-1.0	1.1
Eye problems/disorders: None of the above	0.3	0.3	0.7	-0.2	-0.5	-0.8
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.2	0.8	-1.5	1.1
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.7	-0.3	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	0.2	0.7	0.0
Neck or shoulder pain in last month	0.7	1.0	3.0	-0.1	0.3	1.7
Medication: Blood pressure	0.1	0.1	0.2	0.5	0.3	0.2
Angina (self-reported)	3.7	4.9	12.3	1.3	-0.8	-3.5
Migraine (self-reported)	0.0	0.1	0.1	0.3	-0.2	0.1
Medication: Ibuprofen	0.4	0.4	0.6	-0.2	-0.8	0.8
Medication: Allopurinol	0.2	0.3	0.7	-0.3	-0.2	0.9
Medication: Omeprazole	0.4	0.4	0.7	-0.8	-0.1	0.8
Medication: Seretide 50 evohaler	0.3	0.4	0.6	0.7	-0.1	0.8
Mean time to correctly identify matches	0.4	0.8	1.2	-1.0	-1.1	-0.5
Heart disease (mother)	1.3	1.6	2.6	1.5	-0.1	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	1.0	-0.9	0.1
Whole body fat mass	0.8	3.5	6.2	2.5	1.1	-1.8
Leg fat mass (right)	0.7	2.9	5.8	2.4	0.8	-1.5
Arm predicted mass (right)	3.1	15.7	28.9	5.4	2.9	-3.1
Pulse rate, automated reading	2.4	7.7	16.0	-2.5	-0.9	4.0
Alcohol intake frequency.	0.4	0.9	1.6	0.2	1.2	1.0
Comparative height size at age 10	1.9	10.5	18.5	4.3	1.9	-3.1
Number of full sisters	0.4	0.5	1.0	-0.3	-0.6	1.0
Suffer from ‘nerves’	0.2	0.3	0.7	-0.8	-0.2	0.6
Overall health rating	0.1	0.3	0.6	0.8	-0.1	0.5
Chest pain or discomfort	0.9	1.2	2.1	-1.1	-1.4	0.7
Had major operations	0.7	0.8	1.2	0.6	-0.9	-1.1
Age at last live birth	1.1	1.7	2.9	-1.4	1.7	0.5
Family relationship satisfaction	0.4	0.5	1.0	-0.7	0.4	1.0
Leg pain on walking	1.1	1.4	2.3	-0.4	1.3	-1.5
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	3.2	1.4	1.4	-1.8
Commuting to job workplace: Car/motor vehicle	1.2	1.4	1.9	-0.7	1.4	1.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.0	-1.7	-0.7	0.8
Medication: Aspirin	0.6	0.8	1.5	-0.4	-1.2	-0.9
Supplements: Vitamin C	0.1	0.1	0.2	0.5	0.2	-0.3
Knee pain experienced in last month	0.1	0.1	0.2	0.0	-0.5	0.4
Hypertension (Self-reported)	0.4	1.2	2.8	-0.7	-1.7	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.8	4.4	8.1	-2.8	0.3	2.2
Illnesses of father: Heart disease	6.2	8.6	12.9	3.6	0.3	-3.6
Illnesses of siblings: Diabetes	1.9	2.4	3.8	1.4	-1.9	-1.1
Smoking status: Previous	1.3	1.9	4.7	1.0	0.1	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	10.8	3.3	0.9	-1.5
Whole body fat-free mass	3.0	17.3	30.1	5.5	3.1	-3.5
Leg fat-free mass (right)	2.7	14.7	23.7	4.9	2.8	-3.5
Arm fat percentage (left)	0.1	0.6	1.1	0.7	-0.3	-1.0
Average weekly red wine intake	2.1	3.1	7.4	-2.7	-0.8	1.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.9	-1.4	-0.3	-0.5
Mood swings	0.6	1.0	2.2	1.5	0.4	-0.8
Loneliness, isolation	1.1	1.5	2.9	1.0	0.7	-1.7
Long-standing illness, disability or infirmity	0.9	1.4	2.4	-1.3	-0.1	-1.6
Ever had bowel cancer screening	1.9	2.2	5.7	-2.4	0.3	0.9
Diabetes diagnosed by doctor	1.9	3.2	5.5	-1.7	-1.1	2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.4	0.1	0.6	0.6
Friendships satisfaction	0.5	0.6	1.2	0.8	1.1	-0.2
Qualifications: nursing, teaching	0.1	0.1	0.3	-0.5	0.3	0.3
Commuting to job workplace: Walk	1.3	1.4	3.6	0.8	-1.9	-0.4
Eye problems/disorders: Cataract	0.9	1.0	1.1	-1.1	0.9	1.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.1	-0.5	-1.2	1.5
Medication for cholesterol	4.6	7.0	12.1	3.5	1.6	-2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.2	1.5	0.8	0.0
Back pain experienced in last month	0.4	0.6	1.0	0.1	0.9	-1.0
Mineral and other dietary supplements	0.4	0.6	1.6	1.2	-0.4	-0.1
Breast cancer (self-reported)	0.3	0.3	0.8	0.3	-0.1	-0.9
Asthma (self-reported)	0.1	0.1	0.2	-0.5	0.3	0.0
Osteoporosis (self-reported)	1.1	1.4	2.4	-0.8	1.5	1.1
Osteoarthritis (self-reported)	0.4	0.5	1.2	-1.1	-0.2	-0.3
Medication: Aspirin	0.7	1.0	1.5	-0.8	-1.2	-0.9
Medication: Gliclazide	2.4	2.7	6.7	-0.0	-2.6	1.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	0.0	0.8	1.2
Smoking status: Current	0.3	0.5	1.0	1.0	-0.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	3.4	-1.8	0.6	1.1
Whole body water mass	3.1	17.5	30.7	5.5	3.1	-3.5
Leg predicted mass (right)	2.7	14.5	23.1	4.8	2.9	-3.5
Arm fat mass (left)	0.8	3.2	5.7	2.4	0.7	-1.9
Number of self-reported non-cancer illnesses	1.6	2.7	6.9	-2.6	-1.0	-0.6
Average weekly champagne plus white wine intake	1.6	2.2	3.2	-1.8	1.7	0.8
Miserableness	0.2	0.4	1.0	-1.0	0.6	-0.0
Guilty feelings	0.5	0.8	1.4	1.2	0.3	-1.0
Wears glasses or contact lenses	0.7	0.8	1.8	-0.8	0.0	-1.3
Ever taken oral contraceptive pill	1.0	1.1	1.7	-0.9	0.9	1.3
Hearing aid user	0.3	0.4	0.9	0.3	1.0	-0.4
Mother’s age at death	0.2	0.2	0.5	-0.4	-0.1	-0.7
Financial situation satisfaction	0.3	0.3	0.7	0.6	-0.8	-0.1
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.1	0.8	1.2	-1.4
Commuting to job workplace: Public transport	1.1	1.3	3.5	-0.6	-1.9	0.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	-0.7	0.1	-0.2
Medication: Blood pressure	1.8	3.4	7.3	-2.7	-1.4	1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.9	0.5	0.2	-1.0
Supplements: Fish oil (including cod liver oil)	1.4	1.9	3.6	-1.9	1.3	-0.7
High cholesterol (Self-reported)	1.4	2.5	5.5	-2.4	-1.1	0.9
Medication: Bendroflumethiazide	0.3	0.5	0.7	0.7	-0.9	0.5
Medication: Paracetamol	0.2	0.3	0.9	1.0	0.2	0.2
Medication: Lisinopril	1.3	1.6	2.3	-1.3	-1.5	1.0
Medication: Atorvastatin	0.1	0.2	0.5	0.1	-0.1	0.7
Illnesses of father: High blood pressure	0.3	0.3	0.5	-0.7	-0.7	-0.2
Alcohol drinker status: Never	0.5	0.6	1.5	1.2	-0.2	-0.7
Ever smoked	0.7	1.2	3.5	0.3	-0.2	-1.9
Basal metabolic rate	3.1	17.4	31.0	5.6	2.9	-3.5
Leg fat percentage (left)	0.1	0.4	0.8	0.9	-0.3	-0.6
Arm fat-free mass (left)	2.9	14.8	27.9	5.3	2.8	-3.0
Number of operations (self-reported)	1.0	1.5	2.6	1.3	-0.2	-1.6
Average weekly beer plus cider intake	0.4	0.6	1.7	1.3	-0.3	-0.2
Irritability	0.3	0.4	0.5	-0.7	-0.6	0.6
Risk taking	0.8	1.2	2.6	0.6	0.8	1.6
Ever had prostate specific antigen (PSA) test	2.1	2.4	3.7	-0.1	-1.9	-1.9
Fractured/broken bones in last 5 years	0.8	1.0	2.0	0.7	1.4	0.7
Age started oral contraceptive pill	1.8	2.3	3.2	-1.8	-0.8	-1.7
Diastolic blood pressure, automated reading	0.2	0.5	1.2	-0.6	-0.0	1.1
Ever depressed for a whole week	1.2	1.4	4.2	-0.1	-0.4	2.0
Unable to work because of sickness or disability	0.3	0.4	1.0	0.2	1.0	0.3
Commuting to job workplace: Cycle	0.6	0.8	2.2	-0.2	-0.3	-1.5
Myopia	0.5	0.7	1.9	-1.4	0.3	-0.2
Vascular/heart problems diagnosed by doctor	0.6	1.7	4.3	0.3	2.1	0.8
Cholesterol lowering medication	2.0	3.0	8.1	-2.9	-0.8	0.5
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.5	-0.7	-0.2	-0.5
Pain experienced in last month	0.2	0.3	0.5	-0.7	0.3	-0.6
Supplements: Calcium	1.6	1.8	2.7	-0.7	1.7	1.5
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	0.5	-0.5	-0.1
Heart attack/myocardial infarction (self-reported)	2.3	2.9	6.0	1.3	-1.1	-2.4
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	2.6	-0.4	1.0	1.6
Heart disease (siblings)	1.9	2.4	4.8	2.2	-0.1	-1.5
Alcohol drinker status: Previous	3.4	3.9	6.7	-2.6	0.9	2.1
Pack years of smoking	0.2	0.3	0.4	0.6	0.7	0.1
Impedance of whole body	0.7	3.3	5.9	-1.7	-2.4	1.1
Leg fat mass (left)	0.8	3.2	6.2	2.5	1.1	-1.5
Arm predicted mass (left)	3.1	15.6	28.8	5.4	3.0	-3.0