TWAS hub - TMEM150A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0980	0.0400	0.00590	0.046	NA	0.049	NA	0.014	5.0e-04	NA	3.2e-04	NA	4.0e-02
2	TCGA	Lung Adenocarcinoma	0.0561	0.0330	0.00420	0.001	0.001	0.020	NA	0.010	2.6e-01	0.22000	1.8e-03	NA	2.0e-02
3	TCGA	Prostate Adenocarcinoma	0.0617	0.0317	0.00029	0.052	0.034	0.038	NA	0.041	3.5e-06	0.00016	7.2e-05	NA	3.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Prostate Cancer	12.0	16.8	37.1	6.1	3.6	0.0
Coronary Artery Disease (CAD)	8.9	10.6	14.8	-3.8	-2.5	-3.3
Angina	8.4	11.0	18.1	-4.3	-1.9	-3.3
Angina (self-reported)	7.8	10.2	17.3	-4.2	-1.7	-3.2
Illnesses of father: Heart disease	7.3	10.1	15.2	-3.8	-0.4	-3.9
Heart attack/myocardial infarction (self-reported)	6.3	8.2	12.0	-3.5	-2.7	-2.3
Heart attack	5.9	7.6	10.8	-3.3	-2.8	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.8	5.6	12.1	2.2	0.2	3.5
Ever had prostate specific antigen (PSA) test	4.7	5.4	7.9	-2.8	-2.3	-1.7
Type 2 Diabetes (T2D) (2018)	4.6	8.6	10.5	3.2	2.9	2.6
Neck or shoulder pain in last month	3.8	5.4	9.7	3.1	1.9	1.8
Arm predicted mass (right)	3.8	19.3	31.7	-5.6	-3.8	-3.5
Arm fat-free mass (right)	3.7	19.1	31.8	-5.6	-3.7	-3.5
Basal metabolic rate	3.7	20.3	32.6	-5.7	-3.1	-4.3
Heel bone mineral density (BMD) T-score, automated (right)	3.6	8.2	12.8	3.3	0.7	3.6
Trunk fat-free mass	3.6	20.8	33.4	-5.8	-3.5	-4.1
Trunk predicted mass	3.6	20.7	32.8	-5.7	-3.5	-4.2
Pulse rate, automated reading	3.6	11.7	14.8	3.9	2.5	3.7
Whole body fat-free mass	3.6	20.4	31.9	-5.7	-3.3	-4.3
Whole body water mass	3.6	20.8	32.7	-5.7	-3.4	-4.3
Alcohol drinker status: Previous	3.6	4.1	5.7	2.4	1.0	2.4
Arm fat-free mass (left)	3.4	17.3	28.9	-5.4	-3.0	-3.7
Leg fat-free mass (right)	3.3	17.8	25.8	-5.1	-2.9	-4.3
Arm predicted mass (left)	3.3	16.6	28.2	-5.3	-2.9	-3.6
Leg predicted mass (left)	3.2	16.8	24.3	-4.9	-2.8	-4.3
Eye problems/disorders: Cataract	3.2	3.7	5.1	2.2	2.0	1.4
Leg predicted mass (right)	3.2	16.9	24.3	-4.9	-2.9	-4.2
Blood White Count	3.1	22.8	30.2	5.5	2.9	5.5
Leg fat-free mass (left)	3.1	16.5	24.0	-4.9	-2.8	-4.2
Heel bone mineral density (BMD) T-score, automated (left)	3.1	6.9	10.3	3.2	0.5	3.2
High blood pressure (mother)	3.1	4.3	6.4	1.1	2.3	-2.5
Eye problems/disorders: Diabetes related eye disease	3.0	3.3	9.4	0.7	3.1	0.1
Weight	3.0	14.7	25.6	-5.1	-1.8	-3.9
Diabetes diagnosed by doctor	3.0	4.9	8.5	1.9	2.9	1.6
Hip circumference	2.9	12.5	21.7	-4.7	-1.9	-3.5
Medication for cholesterol	2.9	4.4	5.5	-2.2	-2.3	-1.7
Eye problems/disorders: None of the above	2.8	3.2	6.4	-1.8	-2.5	-0.2
Smoking status: Previous	2.8	4.1	6.5	-2.1	-2.5	-1.2
Standing height	2.7	26.4	42.2	-6.5	-3.5	-5.0
Heart disease (siblings)	2.7	3.3	7.3	-2.7	-0.6	-1.4
Diabetes (self-reported)	2.6	3.9	6.2	2.0	2.5	1.3
Hayfever/allergic rhinitis (self-reported)	2.6	3.5	10.0	0.5	3.2	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	5.5	-2.2	0.1	-2.3
Qualifications: NVQ or HND or HNC or equivalent	2.6	3.1	5.8	-1.3	-2.4	-1.4
Age at First Birth	2.5	3.7	8.2	1.4	2.9	0.8
Height	2.5	49.1	74.5	-8.6	-3.9	-7.6
Breast cancer (self-reported)	2.5	3.0	7.0	-2.7	-0.5	-1.3
Pulse rate	2.4	4.0	7.5	2.1	0.4	2.7
Heart disease (mother)	2.4	2.9	4.3	-2.1	-0.6	-2.0
Illnesses of father: None of the above (group 1)	2.4	2.9	4.9	1.4	-1.4	2.2
Number of incorrect matches in round	2.3	3.7	7.7	-1.9	-2.8	-0.2
Loneliness, isolation	2.3	3.2	4.8	-2.1	-2.2	-0.8
Blood Eosinophil Count	2.2	16.7	26.1	5.1	2.7	4.1
Ever taken oral contraceptive pill	2.2	2.5	6.2	2.5	0.8	0.7
Schizophrenia vs Biploar Disorder	2.1	2.8	6.4	0.2	-1.4	2.5
Neuroticism (2016)	2.1	3.1	4.6	-1.8	-2.2	-1.1
Tinnitus: Yes, but not now, but have in the past	2.1	2.2	4.9	1.2	0.6	2.2
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	5.4	-2.3	-1.8	-2.1
Lung cancer (father)	2.0	2.3	3.9	2.0	0.6	1.7
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	3.7	1.9	0.9	1.6
Medication: Bendroflumethiazide	2.0	3.1	7.5	0.9	2.7	-0.9
LDL Cholesterol	1.9	2.9	5.4	1.3	1.3	2.3
Diabetes (mother)	1.9	2.4	2.6	1.6	1.6	1.4
Stomach or abdominal pain in last month	1.9	2.3	4.5	2.1	0.8	1.4
Depression (self-reported)	1.9	2.2	3.8	-1.7	-0.2	-1.9
Risk taking	1.9	2.8	4.9	1.9	-0.0	2.2
Waist Hip Ratio (WHR)	1.8	8.2	17.0	2.7	4.1	0.7
Hand grip strength (right)	1.8	4.9	8.5	-2.9	-1.3	-2.1
Headache pain in last month	1.8	3.1	3.8	1.8	1.4	1.9
Schizophrenia (2018)	1.7	3.6	7.0	-1.7	-2.7	-0.9
Hand grip strength (left)	1.7	4.5	7.2	-2.7	-1.5	-2.0
Medication: Atenolol	1.7	2.1	3.3	-0.9	-1.4	-1.8
Sitting height	1.7	11.8	18.6	-4.3	-3.6	-2.0
Long-standing illness, disability or infirmity	1.7	2.6	5.9	-0.3	1.3	-2.4
Alcohol drinker status: Never	1.7	2.1	3.1	-1.8	-1.2	-1.3
Ever depressed for a whole week	1.7	2.1	5.0	1.0	-0.6	2.2
Body Mass Index (BMI) (2010)	1.6	2.2	4.2	-2.1	-1.3	-0.8
Medication for hormone replacement therapy	1.6	1.7	3.3	1.3	0.4	1.8
Past tobacco smoking	1.6	3.0	6.4	1.4	2.5	0.7
Forced vital capacity (FVC)	1.6	6.0	9.2	-2.8	-3.0	-0.8
Mouth/teeth dental problems	1.6	2.5	3.0	-1.3	-1.7	-1.7
Forced expiratory volume in 1-second (FEV1)	1.6	5.2	9.2	-2.5	-3.0	-0.5
Medication: Allopurinol	1.6	2.1	3.6	1.4	-0.9	1.9
Comparative height size at age 10	1.6	9.0	16.2	-4.0	-1.7	-2.9
Illnesses of siblings: Diabetes	1.6	1.9	5.0	-2.2	-0.2	-0.9
Ovarian Cancer	1.5	2.0	2.9	-1.7	-1.7	-0.2
Relative age voice broke	1.5	2.3	4.3	1.6	2.1	0.3
Trunk fat mass	1.5	6.5	11.9	-3.5	-0.0	-2.8
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	3.5	1.7	1.9	1.0
Supplements: Calcium	1.5	1.7	2.2	1.4	1.5	0.9
Heel T-Score	1.4	10.8	18.3	3.6	0.9	4.3
Blood clot in the leg (DVT)	1.4	1.8	3.8	1.1	1.9	0.6
Age started oral contraceptive pill	1.4	1.8	4.0	-1.1	0.5	-2.0
HbA1C	1.3	1.4	3.6	0.8	1.9	0.4
Ever had hysterectomy (womb removed)	1.3	1.4	1.8	-1.3	0.9	-1.3
Alcohol intake versus 10 years previously	1.3	1.9	2.9	1.7	0.9	1.5
Medication: Omeprazole	1.3	1.5	2.6	0.7	1.6	1.2
Whole body fat mass	1.3	5.4	10.2	-3.2	0.0	-2.5
Commuting to job workplace: Car/motor vehicle	1.3	1.4	3.2	0.6	1.8	0.9
Average weekly spirits intake	1.2	1.5	2.3	-1.2	0.9	-1.5
Maternal smoking around birth	1.2	1.8	2.9	-1.4	-0.7	-1.7
Pain all over the body in last month	1.2	1.3	2.6	-1.6	-0.3	-1.1
Illnesses of siblings	1.2	1.6	3.0	1.7	1.3	0.5
Illnesses of mother	1.2	1.5	2.3	-0.3	-1.5	1.5
Chronic bronchitis/emphysema (mother)	1.2	1.5	3.8	0.7	2.0	0.3
Age at first live birth	1.2	2.2	5.1	2.3	1.2	0.1
Leg fat mass (right)	1.2	4.8	9.2	-3.0	0.0	-2.3
Commuting to job workplace: Walk	1.2	1.2	1.5	-1.2	-1.2	-1.0
Osteoporosis (self-reported)	1.2	1.4	2.4	1.6	1.1	0.8
Arm fat mass (left)	1.2	4.9	9.4	-3.1	-0.6	-2.2
Leg fat mass (left)	1.2	4.6	9.0	-3.0	-0.0	-2.2
Major Depression (MDD)	1.1	1.3	2.1	-1.0	-0.9	-1.4
Bipolar Disorder (2011)	1.1	1.0	1.5	0.9	1.2	-0.9
Diabetes (father)	1.1	1.4	3.1	-0.8	1.8	-0.5
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.0	-0.9	0.2	-1.7
Waist circumference	1.1	4.2	7.0	-2.6	0.6	-2.3
Allergy	1.1	2.4	7.2	-0.4	-2.7	-0.0
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.2	0.6	1.8	-0.3
Medication: Cholesterol lowering	1.1	1.6	4.1	0.0	2.0	-0.9
Arm fat mass (right)	1.1	4.4	7.8	-2.8	-0.3	-2.3
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	3.8	-0.5	-1.9	1.2
Forced vital capacity (FVC), Best measure	1.1	3.9	6.0	-2.5	-2.3	-0.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.1	1.4	0.7	1.2
Osteoarthritis (self-reported)	1.1	1.4	3.3	-0.1	1.8	-0.9
Number of self-reported non-cancer illnesses	1.1	1.8	2.8	-1.0	1.7	-1.3
Cholesterol lowering medication	1.1	1.6	4.0	0.5	2.0	-0.6
Bipolar Disorder (2018)	1.0	1.5	2.3	0.8	1.5	-1.2
Schizophrenia (2014)	1.0	2.2	4.4	-1.2	-2.1	-0.8
Father’s age at death	1.0	1.3	1.9	1.3	1.4	0.6
Qualifications: A levels/AS levels or equivalent	1.0	2.2	5.3	2.3	1.0	0.3
Number of children fathered	1.0	1.1	1.8	1.2	-0.0	1.3
High cholesterol (Self-reported)	1.0	1.7	4.9	0.1	2.2	-0.4
Basal cell carcinoma (self-reported)	1.0	1.2	2.4	-1.5	-0.2	-1.1
Townsend deprivation index at recruitment	0.9	1.3	2.2	-1.5	-0.9	-0.9
Number of live births	0.9	1.3	3.8	0.0	-2.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	5.3	-1.7	-2.3	-0.1
Family relationship satisfaction	0.9	1.1	2.0	1.4	1.2	0.1
Leg pain on walking	0.9	1.2	1.4	-1.2	-1.0	-1.0
Knee pain experienced in last month	0.9	1.5	2.3	1.5	1.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	2.9	1.7	0.5	1.7
Ever smoked	0.9	1.6	3.1	-1.0	-1.8	-0.9
Commuting to job workplace: Cycle	0.9	1.1	2.1	0.3	-1.1	-1.5
Myopia	0.9	1.3	3.3	-0.3	1.8	-0.7
Pain experienced in last month	0.9	1.5	3.1	-1.8	-0.6	-1.0
Cardiovascular Disease	0.8	2.6	5.2	1.6	2.3	-0.2
Number of treatments/medications taken	0.8	1.4	2.8	1.1	1.7	0.3
Nervous feelings	0.8	1.6	3.1	1.3	1.8	-0.0
Gout (self-reported)	0.8	1.1	1.7	1.0	-0.8	1.3
Exposure to tobacco smoke outside home	0.8	1.1	1.6	1.3	0.9	1.0
Alcohol intake frequency.	0.8	1.9	3.4	1.8	1.5	0.3
Ever had bowel cancer screening	0.8	1.0	1.6	0.4	1.3	1.0
Medication: Blood pressure	0.8	1.5	3.0	1.2	1.7	0.3
Number of operations (self-reported)	0.8	1.2	2.0	-1.4	-0.5	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	2.8	0.6	1.7	0.3
Lupus	0.7	1.0	1.4	0.8	1.2	1.0
Respiratory disease	0.7	1.5	3.7	0.7	1.9	0.4
Severe depression (siblings)	0.7	0.8	2.3	0.4	0.1	1.5
Trunk fat percentage	0.7	2.7	4.5	-2.1	0.8	-1.7
Multivitamins +/- minerals	0.7	0.8	1.3	1.2	0.1	1.1
Medication: Levothyroxine sodium	0.7	1.2	3.1	-0.3	0.6	-1.8
Birth weight of first child	0.7	1.3	2.5	-0.7	1.6	-0.9
Loud music exposure frequency	0.7	0.8	1.6	0.7	0.6	1.3
Medication: Ibuprofen	0.7	0.8	1.4	1.0	0.2	1.2
Number of full sisters	0.7	0.8	2.1	0.6	-0.3	1.5
Had major operations	0.7	0.8	2.0	-0.4	0.3	-1.4
Mood swings	0.7	1.3	3.2	-0.9	-1.8	-0.1
Medication: Gliclazide	0.7	0.8	1.1	0.9	1.1	0.8
Impedance of whole body	0.7	3.5	4.4	2.1	1.7	1.8
Crohns Disease (2017)	0.6	1.3	1.9	-1.4	-0.7	-1.3
Irritable Bowel Disease (IBD)	0.6	1.5	3.4	-1.8	-0.6	-0.9
Ulcerative Colitis (UC)	0.6	1.2	3.0	-1.7	-0.7	-0.4
Primary Biliary Cirrhosis	0.6	0.9	1.9	-1.4	0.2	-0.8
Impedance of leg (right)	0.6	2.7	3.6	1.4	1.6	1.9
Average weekly fortified wine intake	0.6	0.7	1.2	0.9	0.4	1.1
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.7	0.1	1.9	-0.1
Body mass index (BMI)	0.6	2.5	4.8	-2.2	-0.3	-1.7
Had other major operations	0.6	0.7	1.4	-1.2	-0.5	-0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.5	0.8	-0.1	1.2
Impedance of arm (right)	0.6	2.8	4.4	2.0	2.1	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.8	0.8	-0.1	1.3
Tense / ‘highly strung’	0.6	1.0	1.4	0.4	1.2	1.2
Hair/balding pattern: Pattern 4	0.6	1.4	2.5	1.3	1.6	0.3
Medication: Amlodipine	0.6	0.9	2.2	0.3	0.5	-1.5
Body fat percentage	0.6	2.3	3.4	-1.8	1.2	-1.5
Pulse wave peak to peak time	0.6	0.7	0.8	-0.9	-0.7	-0.9
Emphysema/chronic bronchitis	0.6	0.7	1.0	-0.9	1.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.8	1.2	-0.9	-1.1	0.5
Age at last live birth	0.6	0.9	2.1	1.5	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.5	1.2	0.6	1.0
Smoking status: Current	0.6	0.9	1.2	1.0	0.8	1.1
Average weekly champagne plus white wine intake	0.6	0.8	1.1	1.1	0.7	0.9
Medication: Atorvastatin	0.6	0.8	1.2	-0.7	1.1	-0.7
Irritability	0.6	1.0	1.9	1.4	-0.4	1.0
Bipolar Disorder or Schizophrenia	0.5	1.3	2.2	-0.8	-1.1	-1.5
Intelligence (Savage-Jansen 2018)	0.5	1.7	3.4	1.1	1.8	0.6
Alzheimer’s Disease (in father)	0.5	0.6	0.9	-0.4	-0.9	-1.0
Alzheimer’s Disease (including proxy)	0.5	0.8	1.2	-1.1	-1.0	-0.3
Breast Cancer	0.5	1.2	2.0	0.3	-1.4	1.2
Rheumatoid Arthritis	0.5	0.7	1.5	0.5	-1.2	0.7
Blood Platelet Count	0.5	5.2	8.0	-2.8	-0.3	2.8
Lung FVC	0.5	2.4	4.8	-1.0	-2.2	1.1
Impedance of leg (left)	0.5	2.5	3.8	1.2	1.5	1.9
Had menopause	0.5	0.6	1.7	0.1	-1.3	-0.4
Financial difficulties in last 2 years	0.5	0.7	1.5	-0.6	-0.3	-1.2
Noisy workplace	0.5	0.6	1.1	0.5	1.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.5	-1.2	-0.6	-0.9
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.3	-1.1	0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.9	1.4	0.6	-0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.3	-0.6	-0.2	-1.5
Comparative body size at age 10	0.5	1.3	2.2	-1.3	0.3	-1.5
Overall health rating	0.5	1.0	2.1	0.9	1.5	-0.3
Supplements: Vitamin C	0.5	0.6	0.8	-0.9	0.5	-0.9
Mother’s age at death	0.5	0.6	1.5	-1.2	0.0	-0.6
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	-0.7	-0.5	-1.0
Medication: Lisinopril	0.5	0.6	1.2	0.8	1.1	-0.0
Fractured/broken bones in last 5 years	0.5	0.6	1.0	1.0	0.8	0.6
Depressed Affect (Nagel 2018)	0.4	0.8	1.4	0.6	-1.2	0.7
Mean Putamen Volume	0.4	0.5	1.0	0.4	-0.5	1.0
Fasting Glucose	0.4	0.5	0.5	0.7	0.7	0.7
Ulcerative Colitis	0.4	0.5	1.5	-1.2	-0.1	0.1
Allergy or Eczema	0.4	1.0	2.7	0.3	1.6	-0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.2	-0.4	-0.1	-1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.3	0.5	-0.2	1.1
Current tobacco smoking	0.4	0.7	0.9	0.7	0.8	0.9
Taking other prescription medications	0.4	0.7	1.4	-0.1	0.7	-1.2
Qualifications: CSEs or equivalent	0.4	0.5	1.1	-0.6	-1.1	-0.2
Fluid intelligence score	0.4	0.8	1.7	0.8	1.3	0.2
Arm fat percentage (right)	0.4	1.5	1.7	-1.2	1.3	-1.2
Impedance of arm (left)	0.4	2.0	3.7	1.9	1.2	0.8
Length of working week for main job	0.4	0.4	0.7	0.7	0.8	0.3
Exposure to tobacco smoke at home	0.4	0.5	1.1	-1.1	-0.3	0.5
Breastfed as a baby	0.4	0.5	1.5	-1.2	-0.3	-0.2
High blood pressure (siblings)	0.4	0.5	1.5	-0.3	-1.2	0.0
Leg fat percentage (right)	0.4	1.5	2.4	-1.5	1.1	-1.0
Worry too long after embarrassment	0.4	0.6	1.8	-0.0	1.3	-0.3
Wheeze or whistling in the chest in last year	0.4	0.8	1.7	0.4	0.7	1.3
Medication: Blood pressure	0.4	0.7	0.9	0.7	1.0	-0.7
Migraine (self-reported)	0.4	0.5	1.1	0.2	1.0	0.7
Medication: Seretide 50 evohaler	0.4	0.5	0.8	0.8	0.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	0.9	-0.8	0.2
Wears glasses or contact lenses	0.4	0.5	0.7	-0.5	-0.7	-0.9
Leg fat percentage (left)	0.4	1.5	2.7	-1.6	0.9	-1.0
Diastolic blood pressure, automated reading	0.4	1.3	2.0	1.4	1.2	0.7
Unable to work because of sickness or disability	0.4	0.5	1.5	0.0	1.2	0.0
Alzheimer’s Disease (in mother)	0.3	0.4	0.8	-0.9	-0.4	0.4
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.9	-0.1	1.4	0.0
Crohns Disease (2012)	0.3	0.5	1.3	-0.4	-1.1	-0.1
Systolic Blood Pressure	0.3	1.3	2.8	1.7	0.9	0.5
Sensitivity / hurt feelings	0.3	0.5	1.3	-0.1	0.3	-1.2
Medication: Metformin	0.3	0.4	1.0	1.0	0.3	0.3
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-0.2	1.0	0.2
High blood pressure	0.3	0.8	1.7	0.5	1.3	-0.6
Qualifications: None of the above	0.3	0.7	1.6	-1.3	-0.7	0.1
Medication: Ramipril	0.3	0.4	1.0	-0.3	1.0	0.4
Medication: Simvastatin	0.3	0.5	1.5	0.1	1.2	-0.0
Medication: Lansoprazole	0.3	0.3	0.6	0.1	-0.8	0.7
Pulse wave Arterial Stiffness index	0.3	0.3	0.4	0.5	0.7	0.6
Medication: Paracetamol	0.3	0.4	0.9	-0.6	-0.2	-1.0
Number of full brothers	0.3	0.4	1.0	0.3	-0.2	1.0
Qualifications: College or University degree	0.3	1.0	2.0	0.9	1.4	-0.3
Suffer from ‘nerves’	0.3	0.5	1.4	-0.3	1.2	-0.0
Chest pain or discomfort	0.3	0.4	0.9	-0.9	0.0	0.6
Hypertension (Self-reported)	0.3	0.8	1.7	0.9	1.3	-0.2
Arm fat percentage (left)	0.3	1.4	2.3	-1.5	0.6	-1.2
Average weekly red wine intake	0.3	0.5	1.5	0.1	1.2	0.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.1	1.1	0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.4	-0.7	0.5
Mineral and other dietary supplements	0.3	0.3	0.6	-0.7	-0.0	-0.7
Miserableness	0.3	0.6	1.1	1.0	-0.5	0.6
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	0.7	-0.5	-0.4
Medication: Paracetamol	0.3	0.4	0.9	0.6	0.9	0.1
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.1	0.8	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.9	0.7	-0.5	1.4
Pack years of smoking	0.3	0.5	0.8	0.9	0.1	-0.8
Worry (Nagel 2018)	0.2	0.5	1.2	0.3	1.1	0.4
Triglycerides	0.2	0.3	0.7	0.4	0.8	-0.1
Blood Red Count	0.2	2.4	3.1	1.5	1.4	1.8
BMI	0.2	1.1	1.9	-1.4	0.4	-1.2
Hypothyroidism (self reported)	0.2	0.4	1.2	0.1	0.1	-1.1
Lung FEV1/FVC ratio	0.2	1.1	2.7	-0.8	-1.6	-0.1
Neuroticism	0.2	0.6	1.1	0.8	-0.1	1.0
Tanning	0.2	1.9	4.5	1.1	0.0	2.1
Systolic blood pressure, automated reading	0.2	0.5	0.9	0.6	1.0	0.4
Medication: Co-codamol	0.2	0.2	0.6	-0.7	0.0	0.1
Pack years adult smoking proportion	0.2	0.3	0.5	0.7	-0.1	-0.7
Alcohol usually taken with meals	0.2	0.4	0.6	-0.8	0.7	0.1
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.3	-0.7	-0.3
Neuroticism score	0.2	0.4	0.6	0.7	0.2	0.8
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.0	0.9	0.0
Pulse wave reflection index	0.2	0.2	0.4	-0.6	0.3	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.3	0.6	0.5
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.6	0.0	0.3	-0.8
Birth weight	0.2	0.5	0.8	-0.8	-0.9	-0.3
Mean time to correctly identify matches	0.2	0.4	0.6	-0.6	0.5	-0.8
Medication: Aspirin	0.2	0.2	0.3	-0.4	-0.5	-0.5
Hearing aid user	0.2	0.2	0.5	0.3	0.2	-0.7
Commuting to job workplace: Public transport	0.2	0.2	0.5	0.7	0.2	-0.4
Illnesses of father: High blood pressure	0.2	0.2	0.4	-0.3	0.6	-0.4
Depression (Nagel 2018)	0.1	0.2	0.4	0.6	-0.3	0.3
HDL Cholesterol	0.1	0.1	0.3	0.3	-0.6	-0.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.4	0.3	0.4
Smoking Status	0.1	0.3	0.8	-0.2	-0.9	0.5
Hair Pigment	0.1	2.9	5.3	-2.3	0.3	-1.8
Hearing difficulty/problems: Yes	0.1	0.1	0.3	0.2	-0.0	-0.6
Supplements: Zinc	0.1	0.1	0.1	-0.1	-0.3	0.3
Fed-up feelings	0.1	0.1	0.2	-0.2	-0.4	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.4	-0.2	0.5
Age when periods started (menarche)	0.1	0.3	0.8	-0.1	-0.9	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.5	0.0	0.3
Supplements: Glucosamine	0.1	0.1	0.3	0.6	0.1	0.3
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.1	0.0	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.4	0.1	-0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.3	0.4	0.4	0.5
Happiness	0.1	0.1	0.3	0.6	-0.1	0.3
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.6	-0.0	-0.1
Prospective memory result	0.1	0.2	0.3	0.4	0.1	0.5
Glaucoma (self-reported)	0.1	0.2	0.2	0.5	-0.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.3	0.0	0.6
Friendships satisfaction	0.1	0.1	0.2	-0.3	0.3	-0.5
Qualifications: nursing, teaching	0.1	0.1	0.2	0.1	0.5	-0.1
Back pain experienced in last month	0.1	0.1	0.1	-0.3	-0.4	-0.3
Medication: Aspirin	0.1	0.2	0.4	-0.3	-0.1	-0.6
Guilty feelings	0.1	0.2	0.3	-0.5	-0.3	-0.3
Financial situation satisfaction	0.1	0.2	0.3	0.3	-0.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.3	0.5	0.3
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.5	-0.1	0.2
Reaction Time	0.0	0.1	0.1	0.1	0.3	-0.3
Chronotype (morning person)	0.0	0.1	0.3	-0.5	-0.2	0.1
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.1	-0.1	-0.3
Relative age of first facial hair	0.0	0.1	0.2	-0.5	0.1	-0.0
Vitamin and mineral supplements	0.0	0.0	0.1	-0.2	-0.2	0.1
Time employed in main current job	0.0	0.0	0.0	0.0	0.1	-0.2
Worrier / anxious feelings	0.0	0.1	0.1	-0.3	-0.2	-0.2
Falls in the last year	0.0	0.0	0.1	0.2	-0.3	-0.0
Asthma	0.0	0.1	0.1	0.2	0.4	0.2
Peak expiratory flow (PEF)	0.0	0.1	0.2	-0.1	0.2	0.4
Health satisfaction	0.0	0.1	0.2	-0.1	0.1	0.4
Shortness of breath walking on level ground	0.0	0.0	0.0	0.0	-0.0	0.0
Medication for pain relief, constipation, heartburn	0.0	0.0	0.0	0.1	0.1	-0.1
Asthma (self-reported)	0.0	0.1	0.2	0.2	0.5	0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.3	-0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	0.3	-0.0	0.2

Hub : Genes

TMEM150A

Models

Trait associations