Best TWAS P=4.99e-11 · Best GWAS P=4.29e-14 conditioned to 1.47e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | FRZB | 0.14 | 0.04 | enet | 16 | 0.05 | 9.6e-05 | -2.4 | -5.1 | 2.9e-07 | 0.27 | 0.92 | 0.01 | FALSE |
| 2 | GTEx | Brain Hypothalamus | PDE1A | 0.24 | -0.01 | enet | 21 | -0.01 | 7.6e-01 | 5.4 | 6.6 | 5.0e-11 | -0.53 | 0.05 | 0.48 | TRUE |
| 3 | GTEx | Liver | NCKAP1 | 0.50 | -0.01 | lasso | 10 | 0.01 | 1.4e-01 | 4.8 | 5.8 | 9.1e-09 | -0.07 | 0.05 | 0.17 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | PDE1A | 0.11 | 0.03 | bslmm | 526 | 0.06 | 3.2e-08 | -7.2 | 5.3 | 1.3e-07 | -0.49 | 0.03 | 0.96 | FALSE |