Best TWAS P=1.96e-11 · Best GWAS P=4.03e-10 conditioned to 0.123
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DHX36 | 0.05 | 0.06 | blup | 357 | 0.05 | 1.3e-06 | -5.1 | -6.1 | 1.2e-09 | -0.48 | 0.84 | 0.16 | FALSE |
2 | GTEx | Adipose Subcutaneous | ARHGEF26 | 0.10 | 0.06 | enet | 8 | 0.07 | 2.2e-06 | -5.1 | 5.2 | 1.5e-07 | 0.36 | 0.79 | 0.20 | FALSE |
3 | GTEx | Ovary | ARHGEF26 | 0.14 | 0.03 | enet | 15 | 0.06 | 1.4e-02 | 6.1 | 6.7 | 2.0e-11 | 0.79 | 0.05 | 0.63 | TRUE |
4 | GTEx | Pancreas | ARHGEF26 | 0.26 | 0.26 | lasso | 5 | 0.28 | 3.2e-12 | -5.0 | 5.9 | 3.0e-09 | 0.44 | 0.78 | 0.22 | FALSE |
5 | GTEx | Skin Not Sun Exposed Suprapubic | ARHGEF26 | 0.13 | 0.11 | lasso | 4 | 0.07 | 6.8e-05 | -5.0 | 5.4 | 7.5e-08 | 0.40 | 0.69 | 0.28 | FALSE |
6 | GTEx | Spleen | DHX36 | 0.39 | 0.09 | enet | 21 | 0.34 | 2.1e-09 | -3.4 | -5.6 | 2.5e-08 | -0.67 | 0.14 | 0.85 | FALSE |
7 | GTEx | Thyroid | ARHGEF26 | 0.09 | 0.07 | enet | 17 | 0.08 | 1.9e-06 | -5.2 | 6.2 | 6.5e-10 | 0.42 | 0.68 | 0.27 | FALSE |
8 | METSIM | Adipose | ARHGEF26 | 0.07 | 0.08 | lasso | 6 | 0.07 | 3.5e-11 | -5.1 | 5.3 | 1.4e-07 | 0.43 | 0.87 | 0.13 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SGEF | 0.04 | 0.04 | enet | 12 | 0.04 | 1.1e-05 | -4.8 | 5.9 | 3.4e-09 | 0.48 | 0.27 | 0.63 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DHX36 | 0.11 | 0.09 | enet | 11 | 0.10 | 6.4e-12 | -4.7 | -5.6 | 2.6e-08 | -0.57 | 0.97 | 0.03 | FALSE |
11 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DHX36 | 0.05 | 0.00 | enet | 9 | 0.01 | 1.0e-01 | -4.0 | -5.1 | 2.9e-07 | -0.78 | 0.01 | 0.61 | FALSE |