Best TWAS P=2.39e-12 · Best GWAS P=2.29e-11 conditioned to 0.327
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PTPN13 | 0.13 | 0.18 | bslmm | 418 | 0.18 | 6.8e-22 | 5.3 | -5.7 | 1.1e-08 | -0.53 | 0.95 | 0.05 | FALSE |
| 2 | GTEx | Adrenal Gland | PTPN13 | 0.15 | 0.05 | lasso | 3 | 0.06 | 2.8e-03 | 6.6 | -5.3 | 1.0e-07 | -0.84 | 0.02 | 0.85 | FALSE |
| 3 | GTEx | Artery Aorta | MAPK10 | 0.15 | 0.17 | enet | 16 | 0.17 | 1.4e-09 | 6.5 | -6.5 | 1.1e-10 | -0.96 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Colon Sigmoid | MAPK10 | 0.25 | 0.11 | lasso | 8 | 0.07 | 1.6e-03 | 6.5 | -7.0 | 2.4e-12 | -0.89 | 0.02 | 0.96 | TRUE |
| 5 | GTEx | Nerve Tibial | MAPK10 | 0.08 | 0.01 | enet | 17 | 0.03 | 1.7e-03 | 6.6 | -5.9 | 3.2e-09 | -0.74 | 0.01 | 0.97 | FALSE |
| 6 | GTEx | Thyroid | PTPN13 | 0.41 | 0.31 | lasso | 6 | 0.30 | 3.2e-23 | 6.7 | 6.5 | 6.4e-11 | 0.99 | 0.01 | 0.99 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PTPN13 | 0.09 | 0.03 | blup | 409 | 0.07 | 4.7e-09 | 5.3 | -5.7 | 1.4e-08 | -0.53 | 0.95 | 0.05 | FALSE |