Best TWAS P=2.31e-12 · Best GWAS P=9.63e-12 conditioned to 0.0151
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Nerve Tibial | AXIN1 | 0.11 | 0.09 | lasso | 2 | 0.06 | 3.9e-05 | -6.1 | 5.4 | 7.6e-08 | -0.72 | 0.15 | 0.80 | FALSE |
| 2 | GTEx | Nerve Tibial | PDIA2 | 0.12 | 0.01 | enet | 13 | 0.06 | 4.4e-05 | -6.8 | 6.7 | 2.0e-11 | -0.87 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Nerve Tibial | ARHGDIG | 0.13 | 0.07 | lasso | 2 | 0.07 | 8.0e-06 | -6.1 | 5.8 | 9.1e-09 | -0.61 | 0.06 | 0.77 | FALSE |
| 4 | GTEx | Testis | AXIN1 | 0.36 | 0.29 | lasso | 3 | 0.28 | 4.3e-13 | -6.1 | -5.7 | 1.4e-08 | 0.70 | 0.16 | 0.84 | FALSE |
| 5 | GTEx | Whole Blood | NME4 | 0.12 | 0.03 | lasso | 5 | 0.04 | 3.0e-04 | 2.9 | 6.1 | 8.7e-10 | -0.56 | 0.04 | 0.93 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | PDIA2 | 0.15 | 0.07 | lasso | 8 | 0.10 | 5.2e-13 | -6.1 | -6.9 | 5.3e-12 | 0.85 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | AXIN1 | 0.03 | 0.01 | blup | 88 | 0.01 | 7.7e-03 | -6.0 | 7.0 | 2.3e-12 | -0.74 | 0.01 | 0.75 | TRUE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC100134368 | 0.03 | 0.00 | enet | 5 | 0.01 | 2.8e-02 | -1.7 | -5.6 | 1.8e-08 | 0.40 | 0.01 | 0.57 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100134368 | 0.05 | 0.00 | blup | 48 | 0.04 | 2.5e-05 | -4.5 | -6.0 | 2.4e-09 | 0.42 | 0.02 | 0.83 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ARHGDIG | 0.09 | 0.01 | blup | 56 | 0.03 | 3.7e-04 | 3.3 | 5.5 | 4.2e-08 | -0.62 | 0.02 | 0.28 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC100134368 | 0.06 | 0.05 | blup | 47 | 0.07 | 3.9e-07 | 2.9 | -5.8 | 9.0e-09 | 0.38 | 0.39 | 0.48 | FALSE |