Hub : Genes

PDIA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.083 0.0310 7.1e-04 0.018 0.027 0.041 0.031 0.041 2.3e-03 2.7e-04 8.8e-06 1.0e-04 8.1e-06
2 GTEx Brain Hippocampus 0.478 0.1313 6.4e-03 -0.012 NA -0.006 NA 0.006 8.0e-01 NA 4.6e-01 NA 2.2e-01
3 GTEx Heart Left Ventricle 0.123 0.0511 8.5e-03 0.044 NA 0.063 NA 0.081 2.3e-03 NA 2.8e-04 NA 4.1e-05
4 GTEx Muscle Skeletal 0.252 0.0716 2.4e-03 -0.002 NA 0.000 NA -0.002 5.6e-01 NA 3.5e-01 NA 5.3e-01
5 GTEx Nerve Tibial 0.122 0.0406 4.7e-04 0.007 NA 0.060 NA 0.050 9.2e-02 NA 4.4e-05 NA 2.0e-04
6 GTEx Pancreas 0.159 0.0650 8.8e-03 0.071 NA 0.037 NA 0.043 6.1e-04 NA 1.1e-02 NA 6.5e-03
7 GTEx Uterus 0.369 0.1240 2.5e-03 0.008 NA 0.008 NA 0.033 2.2e-01 NA 2.1e-01 NA 7.4e-02
8 ROSMAP Brain Pre-frontal Cortex 0.155 0.0377 1.8e-09 0.071 0.077 0.101 0.083 0.102 1.7e-09 4.4e-10 5.9e-13 7.3e-11 5.2e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.8 1.3 4.4 1.0 0.8 -1.9 0.0 0.5 -2.1 0.7 -0.1
Bipolar Disorder or Schizophrenia 0.4 1.1 4.8 0.8 0.6 -1.1 0.0 0.5 -1.1 2.2 -0.2
Depressed Affect (Nagel 2018) 0.6 1.2 6.1 -0.3 -0.4 -0.9 0.0 0.9 -0.8 -2.5 -0.9
Depression (Nagel 2018) 0.5 0.8 1.6 -1.0 0.9 0.4 0.0 1.1 0.3 -1.3 -1.1
Intelligence (Savage-Jansen 2018) 0.8 2.6 5.5 -1.7 -2.0 0.9 0.0 -2.3 1.3 0.9 2.3
Neuroticism (Nagel 2018) 0.1 0.3 1.6 0.3 -0.4 -0.1 0.0 0.4 0.2 -1.3 -0.4
Schizophrenia (2018) 0.3 0.6 4.8 0.2 0.2 0.0 0.0 0.3 0.3 2.2 -0.2
Schizophrenia vs Biploar Disorder 0.0 0.0 0.3 -0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.3 0.7 2.0 0.2 0.8 0.9 0.0 0.6 1.4 0.8 -0.9
Alzheimer’s Disease (in mother) 0.1 0.1 0.7 -0.8 -0.1 0.6 0.0 -0.1 0.2 0.3 -0.1
Alzheimer’s Disease (in father) 0.7 0.7 3.0 -0.2 -0.6 0.7 0.0 0.7 0.7 -1.7 -1.0
Alzheimer’s Disease (including proxy) 0.8 1.2 2.2 -1.4 -1.0 1.4 0.0 -0.5 1.4 -1.5 0.0
Crohns Disease (2017) 0.1 0.1 0.5 -0.2 0.7 0.3 0.0 0.3 0.4 -0.4 -0.3
Irritable Bowel Disease (IBD) 0.1 0.2 0.6 -0.4 -0.2 0.8 0.0 0.1 0.7 -0.1 0.4
Ulcerative Colitis (UC) 0.3 0.6 1.6 -0.5 -1.3 0.9 0.0 -0.4 0.8 -0.2 1.1
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.3 0.6 1.8 0.8 0.4 -0.7 0.0 0.5 -1.1 1.4 -0.7
Verbal and Numeric Reasoning (VNR) 0.6 1.4 3.2 -0.9 0.1 0.9 0.0 -1.8 0.7 1.5 1.8
Breast Cancer 0.2 0.5 2.2 -0.7 1.5 0.4 0.0 -0.0 0.4 -0.9 -0.1
Ovarian Cancer 0.1 0.2 1.0 0.4 0.5 -0.1 0.0 0.1 0.1 1.0 0.2
Prostate Cancer 1.6 2.3 4.7 1.4 -0.1 -1.9 0.0 -1.9 -1.9 1.0 2.2
Age at First Birth 1.7 2.5 5.7 1.9 -1.2 -2.1 0.0 -0.5 -1.7 2.4 1.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.1 2.9 11.2 -1.2 0.0 0.3 0.0 3.2 0.3 -0.3 -3.4
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.1 0.1 0.4 0.4 -0.4 -0.2 0.0 0.6 0.1 0.3 -0.5
Mean Putamen Volume 0.3 0.3 0.5 -0.0 0.7 -0.3 0.0 -0.7 -0.5 -0.7 0.7
Fasting Glucose 0.9 1.0 3.2 -1.4 -1.8 0.9 0.0 -1.0 1.1 0.2 -0.2
HbA1C 0.5 0.5 1.8 1.4 1.0 0.5 0.0 0.0 0.4 -0.8 -0.3
HDL Cholesterol 0.6 0.9 2.2 1.5 0.0 -0.8 0.0 -1.1 -0.8 1.0 1.4
LDL Cholesterol 0.8 1.3 2.8 -0.7 0.0 1.0 0.0 1.5 1.1 -1.5 -1.7
Lupus 0.3 0.4 1.8 -0.3 0.2 -1.3 0.0 -0.3 -1.1 0.3 0.3
Neuroticism (2016) 1.0 1.4 4.5 1.5 0.2 -1.2 0.0 1.4 -2.1 -0.2 -0.7
Primary Biliary Cirrhosis 0.4 0.5 1.6 -0.7 -1.2 0.7 0.0 0.5 0.5 -0.5 -0.9
Rheumatoid Arthritis 1.0 1.4 4.4 1.1 0.3 -0.7 0.0 2.0 -0.9 0.1 -2.1
Schizophrenia (2014) 0.3 0.6 2.9 -0.3 0.7 0.7 0.0 -0.2 0.8 1.7 0.2
Triglycerides 0.5 0.8 2.5 -1.6 0.0 1.2 0.0 0.4 1.2 -0.7 -0.5
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.7 1.0 3.6 -0.8 -1.9 0.9 0.0 -0.5 1.0 0.4 1.2
Blood Eosinophil Count 0.1 1.1 5.9 0.1 0.6 1.3 0.0 -0.5 0.6 2.4 0.2
Blood Platelet Count 0.7 7.9 36.4 -1.2 -2.0 2.6 0.0 1.5 2.4 -6.0 -2.5
Blood Red Count 0.8 7.9 34.0 2.3 0.6 3.3 0.0 2.8 2.0 -0.3 -5.8
Blood White Count 0.2 1.4 5.0 -0.9 1.2 0.5 0.0 1.6 0.4 -0.9 -2.2
Heel T-Score 0.5 4.4 11.5 -2.8 -2.4 0.6 0.0 -2.1 -0.6 -3.4 2.2
BMI 2.5 14.7 51.6 0.6 1.5 -2.0 0.0 7.2 -2.5 -2.6 -6.9
Height 0.7 12.5 84.6 -0.2 -2.6 -1.2 0.0 -0.6 -2.3 9.2 1.4
Waist Hip Ratio (WHR) 0.2 1.1 3.6 0.9 0.6 0.0 0.0 1.0 0.2 1.7 -1.9
Systolic Blood Pressure 1.0 4.8 15.1 1.2 1.6 -0.8 0.0 3.6 -0.4 2.3 -3.9
Smoking Status 1.9 4.6 23.5 0.3 1.8 0.4 0.0 2.3 0.0 -4.8 -2.2
Allergy or Eczema 0.1 0.4 2.1 -0.1 -1.4 0.3 0.0 -0.6 0.5 0.2 0.4
Cardiovascular Disease 2.4 8.0 31.8 -1.3 1.4 1.5 0.0 4.7 1.9 0.6 -5.6
Hypothyroidism (self reported) 0.4 0.8 2.4 -0.8 -1.4 1.0 0.0 -0.1 1.5 -0.9 -0.4
Respiratory disease 0.7 1.5 7.6 -0.1 0.2 -0.7 0.0 0.9 -0.3 -2.8 -1.6
Type 2 Diabetes (T2D) (2018) 2.5 4.7 18.1 0.0 4.3 0.5 0.0 2.5 0.5 -1.0 -3.4
Lung FEV1/FVC ratio 0.1 0.5 2.7 0.3 -1.7 -0.4 0.0 0.1 -0.5 0.8 -0.3
Lung FVC 0.3 1.6 9.8 0.8 0.7 -0.9 0.0 -0.2 -0.5 -3.1 0.7
Neuroticism 0.6 1.4 4.7 0.2 0.5 -0.2 0.0 2.1 -0.2 -1.1 -2.2
Chronotype (morning person) 0.7 1.6 6.9 -2.6 0.2 1.9 0.0 -0.1 1.3 0.6 -0.3
Hair Pigment 0.1 2.0 6.2 -0.4 1.0 0.6 0.0 2.2 0.5 1.6 -2.5
Tanning 0.1 1.6 4.6 1.4 -0.8 -1.8 0.0 -0.4 -2.1 1.2 0.9
Hand grip strength (left) 0.3 0.8 2.0 -1.4 -1.3 0.7 0.0 -0.8 0.2 -0.1 1.1
Number of treatments/medications taken 2.0 3.6 13.0 0.7 1.4 -1.4 0.0 3.4 -0.3 -0.2 -3.6
Average weekly spirits intake 1.0 1.2 4.0 -0.6 -0.3 -0.2 0.0 1.9 0.7 1.0 -2.0
Sensitivity / hurt feelings 1.0 1.6 4.1 -0.7 -1.2 1.7 0.0 -1.0 1.4 2.0 1.2
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.7 -1.6 -0.5 1.4 0.0 1.1 1.3 -0.1 -0.7
Hearing difficulty/problems: Yes 1.0 1.6 2.9 0.7 1.1 -1.2 0.0 1.7 -1.5 -1.4 -1.6
Relative age of first facial hair 0.5 0.9 3.0 1.3 0.1 -1.4 0.0 -0.5 -1.7 0.5 0.5
Other serious medical condition/disability diagnosed by doctor 2.6 3.4 7.4 1.1 2.7 -1.5 0.0 2.6 -0.9 -1.8 -2.3
Ever used hormone-replacement therapy (HRT) 1.6 2.0 5.5 0.8 2.3 -1.4 0.0 1.4 -2.0 -1.1 -1.1
Ever had hysterectomy (womb removed) 0.6 0.7 1.5 -0.6 0.8 1.2 0.0 0.4 1.2 1.2 -0.7
Systolic blood pressure, automated reading 2.1 6.2 19.4 2.4 1.7 -1.6 0.0 4.2 -1.3 0.5 -4.4
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.0 1.4 1.2 -1.3 0.0 0.9 -1.2 0.7 -0.9
Angina 2.0 2.6 4.6 1.6 2.2 -1.8 0.0 1.8 -1.4 1.9 -1.3
Medication for hormone replacement therapy 0.5 0.6 2.4 0.6 1.6 -0.7 0.0 0.4 -0.9 -0.5 -0.5
Vitamin and mineral supplements 1.0 1.3 3.8 -0.8 -1.2 1.0 0.0 -1.9 0.7 -1.0 1.4
Supplements: Zinc 0.8 0.8 2.9 -1.0 0.6 1.1 0.0 0.8 1.7 0.0 -0.8
Medication: Co-codamol 1.3 1.5 5.8 -0.5 0.2 0.1 0.0 2.0 0.1 -1.2 -2.4
Medication: Metformin 1.4 2.0 6.8 0.1 2.6 0.5 0.0 1.8 0.9 -0.4 -2.3
Diabetes (father) 2.8 3.4 9.5 0.3 3.1 0.4 0.0 1.5 1.0 -2.8 -2.5
Diabetes (mother) 0.3 0.4 1.5 0.2 0.2 1.0 0.0 0.5 0.1 -0.8 -1.2
Severe depression (siblings) 0.7 0.8 2.0 -0.4 -0.1 1.4 0.0 -0.3 1.4 -1.4 -0.0
Pack years adult smoking proportion 1.0 1.5 5.4 -0.2 1.3 -0.2 0.0 2.1 0.2 -0.2 -2.3
Impedance of leg (right) 1.0 4.8 17.6 -0.5 -1.0 1.8 0.0 -4.2 1.9 -0.7 3.5
Leg fat-free mass (left) 1.2 6.6 19.7 -0.8 -0.5 -1.7 0.0 4.4 -2.3 2.9 -3.9
Trunk fat percentage 2.6 10.2 35.6 -0.2 1.5 -1.3 0.0 5.8 -1.4 -2.5 -6.0
Hand grip strength (right) 1.3 3.6 8.7 -2.9 -1.6 2.3 0.0 -2.2 2.1 -0.2 1.8
Townsend deprivation index at recruitment 1.2 1.7 5.2 -0.3 1.1 0.7 0.0 1.8 0.6 -1.7 -2.3
Current tobacco smoking 1.4 2.3 8.3 -0.4 0.8 0.9 0.0 1.8 1.0 -2.9 -2.2
Average weekly fortified wine intake 0.1 0.1 0.3 0.4 0.5 -0.1 0.0 -0.5 0.3 0.2 -0.1
Maternal smoking around birth 3.1 4.5 13.2 0.5 2.7 -1.2 0.0 3.6 -1.2 -1.3 -3.2
Fed-up feelings 0.4 0.7 2.2 0.0 -0.6 -0.8 0.0 0.9 -1.1 -1.5 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.7 -0.5 -0.2 0.3 0.0 1.2 0.2 -1.3 -1.3
Relative age voice broke 0.3 0.5 1.3 0.8 -1.2 -0.1 0.0 -0.7 -0.8 0.6 0.7
Taking other prescription medications 0.9 1.5 4.9 0.5 1.3 -1.1 0.0 2.2 -0.3 -0.5 -1.8
Age when periods started (menarche) 3.0 7.1 17.3 -2.3 -2.5 4.0 0.0 -3.0 4.2 -0.0 2.0
Bilateral oophorectomy (both ovaries removed) 1.0 1.2 7.1 -1.1 2.7 0.3 0.0 -0.5 -0.2 0.1 0.8
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.6 5.7 -1.4 2.1 0.4 0.0 2.3 -0.7 -1.7 -2.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 2.0 -1.4 0.2 0.3 0.0 0.8 0.1 0.9 -0.8
Qualifications: CSEs or equivalent 1.2 1.5 5.3 -0.4 2.3 0.7 0.0 1.7 0.3 -0.8 -1.7
Serious illness, injury or assault to yourself 3.9 4.7 11.5 1.4 1.5 -1.9 0.0 3.2 -1.5 -2.2 -3.4
High blood pressure 2.4 6.6 21.7 -1.3 0.1 2.5 0.0 3.6 2.9 1.5 -4.7
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.1 -1.0 -0.2 1.1 0.0 -0.0 1.0 -0.1 -0.6
Multivitamins +/- minerals 1.0 1.3 3.9 0.8 0.2 -0.8 0.0 2.0 -0.6 1.1 -1.8
Stomach or abdominal pain in last month 2.4 3.0 8.7 1.0 1.0 -1.7 0.0 2.5 -1.7 -1.0 -2.9
Supplements: Glucosamine 0.8 1.0 2.6 0.5 -0.1 -1.1 0.0 1.3 -1.0 -1.6 -1.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.1 0.3 0.1 -0.3 0.0 -0.1 -0.5 -1.0 0.2
Medication: Atenolol 2.3 2.9 8.6 0.6 2.9 -0.8 0.0 2.2 -0.6 1.7 -2.3
Medication: Levothyroxine sodium 0.3 0.6 1.7 -0.1 -0.6 0.9 0.0 0.3 1.1 -1.3 -0.8
Sitting height 1.0 7.4 29.3 -0.6 -4.2 -1.5 0.0 -1.3 -2.1 5.4 1.8
Chronic bronchitis/emphysema (father) 1.4 1.7 5.6 0.6 -0.4 -2.4 0.0 1.0 -2.0 -1.0 -1.1
High blood pressure (mother) 1.3 1.8 6.7 -1.3 -0.3 2.6 0.0 -0.5 2.4 0.2 -0.5
Body mass index (BMI) 3.3 14.0 48.7 0.3 1.9 -1.4 0.0 6.9 -1.6 -2.8 -7.0
Impedance of leg (left) 0.9 4.6 15.8 -0.6 -0.6 1.7 0.0 -4.0 2.0 -1.1 3.5
Leg predicted mass (left) 1.3 6.7 19.8 -0.7 -0.5 -1.9 0.0 4.5 -2.5 2.9 -3.9
Trunk fat mass 2.1 9.0 33.1 -0.5 0.5 -1.4 0.0 5.7 -1.7 -1.1 -5.8
Waist circumference 2.7 9.9 42.4 0.1 1.0 -0.6 0.0 5.9 -0.7 -0.5 -6.5
Number of incorrect matches in round 2.6 4.4 7.7 2.6 -2.4 -2.8 0.0 0.3 -2.7 2.7 0.1
Past tobacco smoking 0.7 1.4 5.5 -0.8 -2.4 -0.2 0.0 -1.0 0.5 1.8 0.3
Alcohol usually taken with meals 1.0 1.6 4.6 0.4 -1.5 0.1 0.0 -1.9 0.2 2.1 1.5
Nervous feelings 0.1 0.1 0.6 0.3 -0.0 -0.0 0.0 0.0 0.3 0.7 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.4 -0.3 -1.6 0.9 0.0 1.3 0.7 -1.1 -1.3
Hearing difficulty/problems with background noise 0.6 0.9 3.7 0.9 0.3 -0.7 0.0 1.0 -0.9 -1.9 -0.9
Hair/balding pattern: Pattern 2 0.3 0.4 1.1 -0.9 -0.4 -0.1 0.0 0.6 -0.4 1.1 -0.4
Had menopause 1.0 1.3 3.2 1.8 0.6 -1.8 0.0 1.0 -1.4 0.1 -0.6
Had other major operations 0.6 0.7 3.9 0.4 0.7 -0.2 0.0 0.7 -0.8 -2.0 -0.5
Forced vital capacity (FVC) 0.3 1.1 2.2 -1.2 -0.6 -0.7 0.0 -1.1 -1.2 1.5 1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 4.2 -0.9 1.1 0.2 0.0 1.3 -1.1 -2.1 -1.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.6 0.4 -0.8 -0.7 0.0 1.6 -0.4 -1.1 -1.4
Qualifications: None of the above 0.6 1.4 5.4 0.4 0.4 -0.7 0.0 1.4 -0.6 -2.3 -1.6
Financial difficulties in last 2 years 2.4 3.3 10.6 -0.2 1.6 -0.4 0.0 3.2 0.0 -1.5 -3.2
Mouth/teeth dental problems 0.4 0.7 2.1 -0.7 -0.6 -0.3 0.0 -0.8 -0.4 1.2 1.5
Heart attack 0.5 0.6 1.8 0.4 -1.0 -0.6 0.0 1.3 -0.9 -0.2 -0.8
Allergy 0.5 1.0 3.1 1.3 0.3 -1.1 0.0 -0.3 -0.9 1.8 1.2
Pain all over the body in last month 0.3 0.3 0.8 -0.1 0.3 0.6 0.0 0.5 0.5 -0.9 -0.9
Diabetes (self-reported) 1.4 2.2 7.4 -0.1 2.7 0.5 0.0 1.9 0.3 0.2 -2.6
Hayfever/allergic rhinitis (self-reported) 0.0 0.0 0.1 -0.2 0.0 -0.3 0.0 0.2 -0.2 0.1 0.1
Medication: Ramipril 0.4 0.5 2.2 -0.4 0.8 1.5 0.0 0.2 0.7 0.3 -0.1
Medication: Simvastatin 2.0 3.0 8.2 -0.1 2.3 -1.1 0.0 2.9 -1.1 -0.5 -2.8
Fluid intelligence score 0.4 0.8 2.6 -0.4 0.1 -0.1 0.0 -1.1 -0.5 1.5 1.6
Illnesses of siblings 5.0 7.1 26.4 -1.9 -1.7 0.8 0.0 -4.6 0.6 -1.0 5.1
Neuroticism score 0.2 0.5 1.2 -0.2 -1.1 0.5 0.0 1.1 0.4 -0.4 -0.8
Weight 1.8 8.8 31.7 -0.3 -0.3 -1.7 0.0 5.6 -2.2 0.6 -5.5
Impedance of arm (right) 0.6 2.8 10.2 -0.7 -0.2 1.0 0.0 -3.2 0.8 -0.2 3.1
Arm fat percentage (right) 3.2 12.7 41.5 -0.2 1.9 -1.1 0.0 6.4 -1.4 -3.6 -6.4
Trunk fat-free mass 0.8 4.5 16.1 -0.5 -2.6 -1.2 0.0 2.1 -1.9 4.0 -1.8
Hip circumference 2.0 8.6 31.5 -0.1 -0.3 -1.6 0.0 5.6 -2.0 -0.3 -5.5
Time employed in main current job 1.3 1.5 3.9 0.5 1.2 -1.0 0.0 2.0 -0.5 1.6 -1.7
Alcohol intake versus 10 years previously 0.3 0.4 2.5 -0.0 -0.3 -0.6 0.0 -0.4 -0.2 -1.6 0.6
Father’s age at death 1.8 2.5 6.8 -1.2 -1.9 0.9 0.0 -2.6 0.7 0.2 2.6
Worrier / anxious feelings 0.5 1.0 3.8 0.0 -1.9 0.6 0.0 -1.1 1.2 0.7 0.9
Frequency of tiredness / lethargy in last 2 weeks 2.0 3.2 9.5 -1.5 -0.5 1.8 0.0 1.7 1.8 -3.1 -2.0
Falls in the last year 2.6 3.6 6.0 2.5 1.4 -2.3 0.0 2.3 -2.4 -0.7 -2.0
Hair/balding pattern: Pattern 3 0.3 0.5 1.4 0.4 -0.3 0.9 0.0 -0.7 1.2 0.9 0.3
Number of live births 0.8 1.1 3.5 1.1 1.1 0.5 0.0 1.6 0.7 -0.1 -1.9
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.6 -0.7 -0.6 -0.8 0.0 -0.4 -1.3 1.0 0.7
Pulse rate 1.4 2.3 9.5 -1.0 1.9 0.1 0.0 1.7 0.2 -3.1 -1.3
Happiness 0.6 0.8 2.6 1.4 -0.2 -1.1 0.0 0.1 -0.4 1.6 -0.5
Noisy workplace 1.9 2.3 7.9 0.9 0.1 -0.8 0.0 2.7 -0.4 -1.3 -2.8
Qualifications: A levels/AS levels or equivalent 1.3 2.8 8.4 1.1 -2.0 -0.3 0.0 -2.2 0.4 1.9 2.9
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.5 -1.1 1.1 1.1 0.0 -0.1 1.6 -0.8 -0.4
Mouth/teeth dental problems: Dentures 1.1 1.8 6.5 1.4 0.4 -0.4 0.0 2.3 -0.7 0.2 -2.6
Asthma 0.3 0.6 3.5 -0.2 -0.1 -0.3 0.0 0.4 -0.2 -1.9 -0.9
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 5.3 -1.0 1.1 0.1 0.0 2.3 0.5 -0.2 -2.1
Medication: Cholesterol lowering 1.2 1.9 6.8 1.0 0.9 -0.3 0.0 2.4 0.2 0.6 -2.6
Depression (self-reported) 0.5 0.6 1.4 -0.6 -0.0 0.8 0.0 1.1 1.2 0.5 -0.7
Medication: Lansoprazole 1.3 1.5 4.2 0.4 2.0 -1.2 0.0 1.7 -0.8 -0.1 -1.7
Prospective memory result 2.4 3.0 8.0 -0.7 -1.5 1.7 0.0 -2.8 1.7 1.4 2.4
Lung cancer (father) 0.2 0.2 1.2 0.2 -1.1 0.0 0.0 0.4 -0.4 -0.1 -0.5
Illnesses of mother 1.0 1.3 4.1 1.2 1.1 -2.0 0.0 0.9 -1.5 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 4.8 0.2 -0.7 -1.6 0.0 0.0 -2.2 0.9 0.3
Pulse wave Arterial Stiffness index 0.4 0.4 1.6 -0.7 0.1 1.2 0.0 0.5 0.9 0.6 -0.5
Impedance of arm (left) 0.4 1.7 7.0 -0.5 -0.1 0.6 0.0 -2.6 0.7 -0.1 2.4
Arm fat mass (right) 2.6 10.7 38.4 -0.4 0.9 -1.3 0.0 6.2 -1.7 -1.9 -6.2
Trunk predicted mass 0.8 4.6 16.4 -0.5 -2.7 -1.2 0.0 2.1 -1.9 4.0 -1.8
Standing height 1.2 12.1 55.5 -1.0 -4.8 -1.2 0.0 -2.2 -2.0 7.5 2.7
Length of working week for main job 0.9 1.0 3.5 -0.1 -1.9 -0.2 0.0 0.6 -0.5 -1.9 -0.6
Exposure to tobacco smoke at home 0.6 0.7 2.4 -0.2 0.5 -0.7 0.0 1.0 -0.6 -1.6 -1.1
Breastfed as a baby 0.8 1.0 2.4 0.6 -0.0 1.2 0.0 -1.4 1.3 1.5 0.4
Tense / ‘highly strung’ 0.4 0.6 3.0 0.4 0.6 -0.0 0.0 1.0 0.3 1.7 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.5 0.3 -0.7 0.6 0.0 1.2 0.5 -1.0 -0.6
Hair/balding pattern: Pattern 4 0.8 1.8 6.2 -1.3 0.4 2.1 0.0 -0.8 2.5 1.1 0.6
Birth weight of first child 0.7 1.3 4.2 -0.5 -2.1 0.6 0.0 -1.6 0.7 0.5 1.6
Peak expiratory flow (PEF) 0.3 0.8 1.9 0.0 0.1 -1.1 0.0 1.1 -1.4 0.9 -1.1
Pulse wave reflection index 0.5 0.6 3.2 0.0 -1.8 1.0 0.0 -0.0 0.6 0.8 -0.1
Ever highly irritable/argumentative for 2 days 1.1 1.3 3.8 0.2 1.1 -0.2 0.0 1.8 -0.2 -1.5 -1.9
Loud music exposure frequency 1.5 1.6 7.4 -0.2 1.9 0.8 0.0 0.1 1.0 -2.7 -0.2
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 6.9 -0.2 0.9 0.2 0.0 -1.7 0.5 1.5 2.6
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.4 0.3 -1.2 -0.3 0.0 -0.9 -0.4 0.0 0.6
Blood clot in the leg (DVT) 1.2 1.6 3.8 -2.0 0.6 1.9 0.0 0.0 1.4 -1.6 -0.1
Medication: Paracetamol 0.9 1.5 4.5 0.6 -0.5 -1.4 0.0 2.1 -1.4 0.3 -1.8
Headache pain in last month 0.4 0.7 3.6 -0.4 0.9 -0.4 0.0 0.5 -0.4 -1.9 -0.7
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 4.8 -1.0 -0.7 0.1 0.0 -2.0 -0.4 -1.5 2.2
Glaucoma (self-reported) 0.7 0.8 2.6 -0.8 -1.6 0.3 0.0 -0.6 0.6 1.4 0.5
Gout (self-reported) 0.1 0.2 0.4 -0.6 0.7 -0.2 0.0 -0.2 -0.3 0.5 0.5
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 2.4 -0.8 -1.3 1.2 0.0 -0.3 1.5 -0.9 -0.1
Medication: Amlodipine 1.2 1.6 4.2 -0.4 -0.4 0.6 0.0 1.9 1.0 1.9 -2.1
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.7 -1.5 -1.6 0.0 0.0 -0.2 0.2 -1.5 -0.2
Birth weight 2.4 5.2 16.5 -1.8 -2.6 0.9 0.0 -3.7 0.8 0.1 4.1
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.8 -0.0 -0.0 0.0 0.0 1.3 -0.3 -0.1 -0.8
High blood pressure (siblings) 3.8 5.5 19.1 1.9 1.6 -0.3 0.0 4.1 -0.1 1.4 -4.4
Forced vital capacity (FVC), Best measure 0.4 1.3 3.6 -0.5 -0.8 -1.3 0.0 -0.9 -1.9 1.4 1.3
Body fat percentage 2.9 11.3 39.1 -0.5 1.6 -1.0 0.0 6.0 -1.1 -3.1 -6.2
Leg fat percentage (right) 2.6 9.3 33.1 -0.3 1.2 -0.4 0.0 5.3 -0.4 -3.4 -5.8
Arm fat-free mass (right) 1.0 4.9 12.1 -0.5 -1.5 -1.5 0.0 3.5 -2.0 2.8 -3.2
Exposure to tobacco smoke outside home 0.8 1.1 2.9 1.7 0.8 -1.1 0.0 0.7 -1.4 -0.0 -1.1
Comparative body size at age 10 1.8 4.9 14.7 -1.8 -1.4 1.5 0.0 2.6 1.4 -3.8 -2.9
Number of full brothers 4.1 5.1 15.7 1.9 1.8 -1.6 0.0 3.4 -1.6 -1.3 -4.0
Worry too long after embarrassment 0.7 1.2 6.9 0.7 -2.6 -0.1 0.0 -0.7 -0.3 0.1 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 2.0 0.0 0.2 -0.3 0.0 1.0 -0.3 -1.4 -0.5
Wheeze or whistling in the chest in last year 1.5 2.6 8.1 -0.8 1.0 0.5 0.0 2.2 -0.1 -2.8 -2.5
Number of children fathered 0.2 0.2 1.0 -0.1 -0.1 -0.1 0.0 -0.2 -0.5 -1.0 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 3.1 1.1 -0.2 -1.8 0.0 1.6 -1.5 -0.8 -1.1
Age at first live birth 1.1 1.9 8.4 0.6 -1.6 -0.1 0.0 -1.0 -0.2 2.9 1.7
Pulse wave peak to peak time 0.5 0.6 2.2 0.9 -0.2 -1.5 0.0 -0.5 -1.1 -0.1 0.6
Health satisfaction 0.4 0.5 1.3 -0.2 0.7 -0.8 0.0 1.0 -0.6 -0.6 -1.1
Shortness of breath walking on level ground 0.8 0.9 5.4 -0.3 0.0 -0.4 0.0 0.5 -0.7 -2.3 -1.1
Qualifications: College or University degree 1.0 3.0 9.2 -0.1 -0.8 -0.6 0.0 -2.3 -0.9 3.0 2.8
Eye problems/disorders: None of the above 0.7 0.8 2.0 0.4 1.4 -0.6 0.0 1.3 -0.6 -0.2 -1.3
Mouth/teeth dental problems: Loose teeth 0.8 0.9 2.8 0.1 0.8 -0.1 0.0 1.5 -0.3 -1.2 -1.7
Emphysema/chronic bronchitis 0.5 0.6 1.7 -1.2 -1.3 0.1 0.0 -0.2 0.2 -1.3 -0.1
Medication for pain relief, constipation, heartburn 2.6 4.5 15.4 0.2 -2.3 0.7 0.0 -3.9 0.2 0.2 3.8
Neck or shoulder pain in last month 1.3 1.9 8.0 -0.7 0.0 0.1 0.0 1.4 0.1 -2.8 -2.1
Medication: Blood pressure 1.4 2.5 8.0 0.5 1.3 -0.2 0.0 2.3 0.3 2.8 -2.2
Angina (self-reported) 1.9 2.5 5.2 1.5 2.3 -1.5 0.0 1.8 -1.2 2.1 -1.3
Migraine (self-reported) 0.5 0.7 2.5 0.1 1.6 -0.9 0.0 0.8 -0.6 0.2 -0.9
Medication: Ibuprofen 0.8 1.0 2.5 -1.2 0.5 0.5 0.0 1.4 1.0 -0.7 -1.6
Medication: Allopurinol 0.4 0.5 1.9 -0.3 0.2 0.2 0.0 -1.2 -0.1 0.9 1.4
Medication: Omeprazole 0.4 0.5 2.0 -0.1 0.2 0.5 0.0 1.4 0.4 -0.3 -1.1
Medication: Seretide 50 evohaler 0.2 0.2 0.8 -0.3 0.3 0.3 0.0 0.9 0.3 -0.1 -0.7
Mean time to correctly identify matches 0.5 1.0 2.9 1.7 0.8 -1.2 0.0 0.5 -1.5 0.5 -0.8
Heart disease (mother) 0.6 0.7 2.9 1.7 0.3 -0.7 0.0 0.6 -0.8 1.0 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 4.7 -0.0 1.6 1.1 0.0 1.9 0.5 0.1 -2.2
Whole body fat mass 2.3 9.6 35.8 -0.8 0.7 -1.0 0.0 5.9 -1.4 -1.5 -6.0
Leg fat mass (right) 2.3 9.1 33.4 -0.5 0.9 -1.1 0.0 5.7 -1.4 -1.7 -5.8
Arm predicted mass (right) 1.0 5.3 11.4 -0.3 -1.9 -1.6 0.0 3.4 -2.2 3.1 -3.1
Pulse rate, automated reading 0.7 2.4 10.7 -0.4 0.7 -0.8 0.0 2.2 -0.7 -3.3 -1.3
Alcohol intake frequency. 0.8 1.8 9.5 -1.2 -0.3 1.1 0.0 -0.3 1.6 -3.1 -0.2
Comparative height size at age 10 0.9 4.8 27.2 0.2 -2.5 -1.3 0.0 0.3 -1.8 5.2 0.5
Number of full sisters 0.6 0.8 2.5 -1.6 1.2 0.3 0.0 0.0 0.7 -1.3 -0.1
Suffer from ‘nerves’ 0.1 0.1 0.3 0.3 -0.6 0.2 0.0 0.2 0.3 -0.5 0.2
Overall health rating 2.8 6.0 18.9 0.4 2.8 -0.6 0.0 4.3 -0.2 -1.6 -4.4
Chest pain or discomfort 1.5 2.1 4.0 1.0 0.7 -1.8 0.0 1.9 -2.0 -1.1 -1.8
Had major operations 0.4 0.5 1.3 0.6 0.6 0.1 0.0 1.0 -0.2 -1.2 -1.0
Age at last live birth 0.4 0.6 2.4 0.7 -1.5 0.5 0.0 0.1 0.4 1.0 0.2
Family relationship satisfaction 0.2 0.2 0.5 -0.1 -0.5 0.5 0.0 -0.7 0.7 0.1 0.5
Leg pain on walking 1.5 1.9 7.5 1.1 0.2 -0.4 0.0 2.4 -0.4 0.3 -2.7
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 6.3 -0.7 1.0 1.1 0.0 0.5 1.4 -2.5 -1.2
Commuting to job workplace: Car/motor vehicle 1.2 1.3 4.3 0.5 2.1 -1.0 0.0 1.5 -1.2 -0.3 -1.2
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 5.2 0.3 -1.4 -0.5 0.0 -1.5 -0.7 2.3 1.7
Medication: Aspirin 1.1 1.4 4.5 0.3 2.0 -0.2 0.0 1.6 0.4 0.3 -2.1
Supplements: Vitamin C 0.6 0.7 1.6 0.6 1.1 0.0 0.0 1.3 0.3 0.9 -1.1
Knee pain experienced in last month 2.4 3.8 10.6 0.1 1.3 -0.0 0.0 2.9 0.1 -3.1 -3.3
Hypertension (Self-reported) 2.1 5.7 20.1 -1.0 0.3 2.2 0.0 3.4 2.6 1.4 -4.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.5 6.4 1.1 2.5 -1.1 0.0 2.4 -1.3 -0.1 -2.0
Illnesses of father: Heart disease 0.2 0.2 0.6 0.4 0.5 0.5 0.0 0.4 0.4 0.5 -0.8
Illnesses of siblings: Diabetes 2.6 3.2 12.7 0.7 0.9 -0.3 0.0 2.8 -0.8 -1.8 -3.6
Smoking status: Previous 0.6 0.8 3.3 0.1 1.8 0.7 0.0 0.5 -0.1 -1.6 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.3 0.8 -0.7 -0.6 -0.1 0.0 0.6 -0.7 0.9 -0.5
Whole body fat-free mass 0.9 5.3 13.0 -0.6 -1.8 -1.5 0.0 3.3 -2.2 3.6 -2.8
Leg fat-free mass (right) 1.2 6.4 18.9 -0.6 -0.4 -1.8 0.0 4.3 -2.4 3.0 -3.6
Arm fat percentage (left) 3.5 14.1 47.6 -0.3 2.0 -1.1 0.0 6.7 -1.4 -3.6 -6.9
Average weekly red wine intake 0.3 0.4 1.2 -0.3 -0.7 1.1 0.0 0.2 1.0 -0.4 -0.4
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.5 -0.5 -0.2 0.3 0.0 -0.3 0.0 -0.5 0.7
Mood swings 0.3 0.6 1.8 -0.2 -1.3 -0.4 0.0 1.0 -0.4 -0.9 -0.6
Loneliness, isolation 1.4 2.0 7.1 -2.7 -2.2 1.3 0.0 -0.4 1.0 -1.0 0.3
Long-standing illness, disability or infirmity 1.8 2.8 12.6 0.4 1.1 -0.3 0.0 1.9 0.2 -3.5 -2.0
Ever had bowel cancer screening 0.6 0.6 2.0 1.1 -0.1 -1.4 0.0 -0.1 -1.1 -0.8 0.2
Diabetes diagnosed by doctor 1.6 2.7 8.9 0.2 2.8 0.3 0.0 2.2 0.4 -0.3 -3.0
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 3.1 -1.8 1.6 1.6 0.0 0.9 1.0 -0.9 -0.7
Friendships satisfaction 0.6 0.7 3.2 1.8 1.1 -0.2 0.0 -0.2 -0.6 0.9 0.1
Qualifications: nursing, teaching 1.1 1.7 3.8 2.0 0.9 -1.6 0.0 -0.6 -1.3 1.6 1.4
Commuting to job workplace: Walk 1.8 1.9 6.5 0.6 -2.5 -0.8 0.0 -1.6 -0.8 -1.0 1.8
Eye problems/disorders: Cataract 0.5 0.5 2.5 -0.3 -1.6 -0.0 0.0 -0.9 0.2 0.1 0.9
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 4.3 -0.2 1.3 0.3 0.0 0.3 0.5 -2.1 -0.4
Medication for cholesterol 0.8 1.2 4.3 0.6 -0.4 -1.4 0.0 -1.2 -1.3 0.6 2.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 2.3 -1.0 1.5 -0.9 0.0 0.2 -0.8 -1.3 0.1
Back pain experienced in last month 2.1 3.0 10.2 1.2 -0.1 -0.4 0.0 2.0 -0.4 -3.2 -2.8
Mineral and other dietary supplements 1.0 1.3 3.5 -1.9 -0.6 1.5 0.0 -1.2 1.1 0.7 1.1
Breast cancer (self-reported) 0.1 0.2 1.1 0.2 -1.0 -0.1 0.0 -0.1 -0.4 0.2 0.1
Asthma (self-reported) 0.3 0.7 3.7 -0.2 -0.2 -0.0 0.0 0.5 0.2 -1.9 -1.2
Osteoporosis (self-reported) 0.3 0.3 1.4 -0.1 0.1 0.1 0.0 -0.7 1.2 -0.8 0.3
Osteoarthritis (self-reported) 1.1 1.4 7.0 -1.1 -0.6 0.7 0.0 0.9 0.8 -2.6 -1.0
Medication: Aspirin 0.9 1.2 3.4 -0.6 1.7 0.4 0.0 1.3 0.8 0.5 -1.8
Medication: Gliclazide 1.5 1.8 4.2 -0.7 1.6 1.4 0.0 1.6 1.3 -0.7 -2.1
Illnesses of father: None of the above (group 1) 1.0 1.2 4.9 0.5 -1.4 -0.2 0.0 -1.0 -0.2 1.1 2.2
Smoking status: Current 1.0 1.6 6.3 -0.2 0.8 0.5 0.0 1.4 0.6 -2.5 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 4.6 1.3 1.2 -1.6 0.0 0.0 -2.1 -0.2 0.5
Whole body water mass 0.9 5.4 11.8 -0.5 -1.7 -1.6 0.0 3.4 -2.3 3.4 -3.0
Leg predicted mass (right) 1.2 6.3 18.8 -0.6 -0.4 -1.9 0.0 4.3 -2.4 3.0 -3.6
Arm fat mass (left) 2.7 11.1 40.7 -0.7 0.9 -1.1 0.0 6.3 -1.5 -1.9 -6.4
Number of self-reported non-cancer illnesses 1.8 3.1 10.2 -0.2 1.9 0.0 0.0 3.0 0.4 -1.3 -3.2
Average weekly champagne plus white wine intake 1.9 2.7 11.9 1.4 -1.1 -1.3 0.0 -1.0 -1.5 3.4 1.1
Miserableness 1.0 1.8 7.9 -0.6 -0.6 0.4 0.0 1.9 -0.2 -2.8 -1.4
Guilty feelings 0.3 0.5 1.1 0.4 0.2 0.7 0.0 1.1 0.7 -0.9 -1.0
Wears glasses or contact lenses 1.0 1.1 4.8 0.9 -2.2 -0.6 0.0 0.4 -0.6 1.4 -0.6
Ever taken oral contraceptive pill 0.4 0.5 0.9 -0.8 -0.0 0.9 0.0 -0.8 1.0 -0.7 0.5
Hearing aid user 1.4 1.6 3.3 1.1 1.8 -1.6 0.0 0.9 -1.5 -1.7 -0.3
Mother’s age at death 3.3 4.1 11.5 0.1 -3.4 0.6 0.0 -3.4 0.1 -0.2 3.1
Financial situation satisfaction 0.4 0.5 1.6 0.4 1.0 0.2 0.0 0.4 0.8 -1.2 -0.5
Tinnitus: Yes, now most or all of the time 1.5 1.7 4.6 -0.6 1.7 1.0 0.0 1.5 1.1 -1.1 -2.1
Commuting to job workplace: Public transport 2.0 2.4 8.8 0.4 -3.0 0.1 0.0 -2.3 1.2 -0.2 1.8
Eye problems/disorders: Glaucoma 0.9 1.0 2.1 -1.4 -1.5 0.4 0.0 -0.6 0.5 1.4 1.1
Medication: Blood pressure 0.9 1.6 5.1 -1.0 0.1 1.3 0.0 1.4 1.4 1.1 -2.3
Pain type(s) experienced in last month: Hip pain 2.7 3.4 8.6 0.8 2.1 -0.7 0.0 2.5 -0.7 -2.9 -2.6
Supplements: Fish oil (including cod liver oil) 1.3 1.7 2.9 1.3 1.7 -0.6 0.0 1.6 -0.7 -1.6 -1.7
High cholesterol (Self-reported) 1.1 1.9 6.2 -0.4 1.1 0.8 0.0 2.1 1.2 -1.1 -2.5
Medication: Bendroflumethiazide 0.9 1.4 4.7 -1.5 -0.9 1.2 0.0 0.2 1.3 2.2 -0.7
Medication: Paracetamol 0.5 0.8 1.7 0.7 -0.3 -1.2 0.0 1.3 -1.0 0.6 -1.2
Medication: Lisinopril 0.4 0.5 1.6 0.8 -0.8 -0.6 0.0 -0.2 0.0 1.2 -0.7
Medication: Atorvastatin 0.6 0.7 2.5 -0.4 1.6 1.1 0.0 0.3 1.1 -0.4 -0.6
Illnesses of father: High blood pressure 0.7 0.9 2.6 -0.6 0.3 1.4 0.0 0.9 1.2 -0.2 -1.6
Alcohol drinker status: Never 0.6 0.7 2.0 -0.6 -1.4 0.1 0.0 -1.1 -0.3 0.6 1.3
Ever smoked 0.8 1.4 7.2 1.1 1.3 -0.1 0.0 0.5 -0.8 -2.7 -0.1
Basal metabolic rate 1.1 5.9 16.3 -0.6 -1.4 -1.5 0.0 4.0 -2.1 2.8 -3.7
Leg fat percentage (left) 2.6 9.4 32.6 -0.3 1.3 -0.3 0.0 5.4 -0.4 -3.4 -5.7
Arm fat-free mass (left) 0.9 4.8 12.4 -0.5 -1.8 -1.4 0.0 3.5 -1.9 2.5 -3.2
Number of operations (self-reported) 1.1 1.6 7.3 0.6 -0.1 0.7 0.0 1.5 0.6 -2.7 -1.4
Average weekly beer plus cider intake 0.1 0.2 0.5 -0.5 0.2 -0.4 0.0 0.6 -0.4 -0.7 -0.5
Irritability 0.6 1.0 2.6 1.1 -1.6 -0.8 0.0 0.5 -1.1 -1.3 0.1
Risk taking 0.4 0.6 3.7 -0.0 0.0 -0.9 0.0 0.3 -0.6 -1.9 -0.2
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.5 0.5 -0.3 -0.2 0.0 -1.2 0.1 -1.2 0.6
Fractured/broken bones in last 5 years 0.7 0.8 3.2 -1.5 1.8 0.1 0.0 0.6 0.1 -0.6 -0.7
Age started oral contraceptive pill 0.3 0.4 0.8 0.9 -0.5 -0.9 0.0 -0.5 -0.5 0.3 0.8
Diastolic blood pressure, automated reading 1.6 4.8 19.1 1.2 2.3 -0.1 0.0 3.6 -0.0 0.2 -4.4
Ever depressed for a whole week 1.4 1.7 5.2 1.5 -0.5 -1.2 0.0 2.3 -1.2 0.3 -1.7
Unable to work because of sickness or disability 3.2 4.2 7.4 -2.2 2.6 0.8 0.0 2.5 0.6 -2.7 -2.7
Commuting to job workplace: Cycle 0.9 1.1 2.8 -1.4 -0.8 0.1 0.0 -1.6 -0.4 0.6 1.7
Myopia 1.1 1.6 4.7 -1.1 -1.2 1.7 0.0 -1.1 2.2 0.7 0.7
Vascular/heart problems diagnosed by doctor 2.6 7.2 24.5 1.2 -0.4 -2.6 0.0 -3.9 -2.9 -1.2 5.0
Cholesterol lowering medication 2.2 3.3 11.6 -0.2 3.4 -0.2 0.0 2.2 -0.2 -1.6 -2.6
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 3.9 -0.5 0.6 0.6 0.0 2.0 0.7 -0.8 -1.7
Pain experienced in last month 2.7 4.6 13.6 -0.6 -1.4 0.1 0.0 -2.8 0.0 3.7 3.6
Supplements: Calcium 0.4 0.5 1.6 -0.3 0.4 -0.2 0.0 -1.0 0.6 0.7 1.3
Basal cell carcinoma (self-reported) 1.9 2.2 8.1 1.5 2.9 -1.9 0.0 0.1 -1.8 -0.3 0.8
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.5 0.8 -0.7 -1.0 0.0 1.6 -1.3 -0.3 -1.0
Deep venous thrombosis (DVT) (self-reported) 1.2 1.6 3.7 -1.9 0.5 1.9 0.0 0.2 1.4 -1.7 -0.4
Heart disease (siblings) 2.9 3.6 11.6 -0.4 2.3 1.1 0.0 2.3 1.7 -1.5 -3.4
Alcohol drinker status: Previous 1.1 1.2 3.8 0.2 0.7 -1.7 0.0 0.8 -1.3 -1.9 -0.1
Pack years of smoking 0.9 1.3 5.0 0.0 0.7 -0.3 0.0 2.1 0.0 0.4 -2.2
Impedance of whole body 0.7 3.7 14.1 -0.8 -0.4 1.2 0.0 -3.8 1.4 -0.2 3.4
Leg fat mass (left) 2.3 9.1 32.9 -0.4 0.9 -1.2 0.0 5.7 -1.4 -1.7 -5.7
Arm predicted mass (left) 0.9 4.7 11.6 -0.2 -1.7 -1.5 0.0 3.4 -2.1 2.5 -3.2