TWAS hub - PDIA2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.083	0.0310	7.1e-04	0.018	0.027	0.041	0.031	0.041	2.3e-03	2.7e-04	8.8e-06	1.0e-04	8.1e-06
2	GTEx	Brain Hippocampus	0.478	0.1313	6.4e-03	-0.012	NA	-0.006	NA	0.006	8.0e-01	NA	4.6e-01	NA	2.2e-01
3	GTEx	Heart Left Ventricle	0.123	0.0511	8.5e-03	0.044	NA	0.063	NA	0.081	2.3e-03	NA	2.8e-04	NA	4.1e-05
4	GTEx	Muscle Skeletal	0.252	0.0716	2.4e-03	-0.002	NA	0.000	NA	-0.002	5.6e-01	NA	3.5e-01	NA	5.3e-01
5	GTEx	Nerve Tibial	0.122	0.0406	4.7e-04	0.007	NA	0.060	NA	0.050	9.2e-02	NA	4.4e-05	NA	2.0e-04
6	GTEx	Pancreas	0.159	0.0650	8.8e-03	0.071	NA	0.037	NA	0.043	6.1e-04	NA	1.1e-02	NA	6.5e-03
7	GTEx	Uterus	0.369	0.1240	2.5e-03	0.008	NA	0.008	NA	0.033	2.2e-01	NA	2.1e-01	NA	7.4e-02
8	ROSMAP	Brain Pre-frontal Cortex	0.155	0.0377	1.8e-09	0.071	0.077	0.101	0.083	0.102	1.7e-09	4.4e-10	5.9e-13	7.3e-11	5.2e-13

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	5	6	7	8
Illnesses of siblings	5.0	7.1	26.4	-1.9	-1.7	0.8	-4.6	0.6	-1.0	5.1
Number of full brothers	4.1	5.1	15.7	1.9	1.8	-1.6	3.4	-1.6	-1.3	-4.0
Serious illness, injury or assault to yourself	3.9	4.7	11.5	1.4	1.5	-1.9	3.2	-1.5	-2.2	-3.4
High blood pressure (siblings)	3.8	5.5	19.1	1.9	1.6	-0.3	4.1	-0.1	1.4	-4.4
Arm fat percentage (left)	3.5	14.1	47.6	-0.3	2.0	-1.1	6.7	-1.4	-3.6	-6.9
Body mass index (BMI)	3.3	14.0	48.7	0.3	1.9	-1.4	6.9	-1.6	-2.8	-7.0
Mother’s age at death	3.3	4.1	11.5	0.1	-3.4	0.6	-3.4	0.1	-0.2	3.1
Arm fat percentage (right)	3.2	12.7	41.5	-0.2	1.9	-1.1	6.4	-1.4	-3.6	-6.4
Unable to work because of sickness or disability	3.2	4.2	7.4	-2.2	2.6	0.8	2.5	0.6	-2.7	-2.7
Maternal smoking around birth	3.1	4.5	13.2	0.5	2.7	-1.2	3.6	-1.2	-1.3	-3.2
Age when periods started (menarche)	3.0	7.1	17.3	-2.3	-2.5	4.0	-3.0	4.2	-0.0	2.0
Body fat percentage	2.9	11.3	39.1	-0.5	1.6	-1.0	6.0	-1.1	-3.1	-6.2
Heart disease (siblings)	2.9	3.6	11.6	-0.4	2.3	1.1	2.3	1.7	-1.5	-3.4
Diabetes (father)	2.8	3.4	9.5	0.3	3.1	0.4	1.5	1.0	-2.8	-2.5
Overall health rating	2.8	6.0	18.9	0.4	2.8	-0.6	4.3	-0.2	-1.6	-4.4
Waist circumference	2.7	9.9	42.4	0.1	1.0	-0.6	5.9	-0.7	-0.5	-6.5
Arm fat mass (left)	2.7	11.1	40.7	-0.7	0.9	-1.1	6.3	-1.5	-1.9	-6.4
Pain type(s) experienced in last month: Hip pain	2.7	3.4	8.6	0.8	2.1	-0.7	2.5	-0.7	-2.9	-2.6
Pain experienced in last month	2.7	4.6	13.6	-0.6	-1.4	0.1	-2.8	0.0	3.7	3.6
Other serious medical condition/disability diagnosed by doctor	2.6	3.4	7.4	1.1	2.7	-1.5	2.6	-0.9	-1.8	-2.3
Trunk fat percentage	2.6	10.2	35.6	-0.2	1.5	-1.3	5.8	-1.4	-2.5	-6.0
Number of incorrect matches in round	2.6	4.4	7.7	2.6	-2.4	-2.8	0.3	-2.7	2.7	0.1
Falls in the last year	2.6	3.6	6.0	2.5	1.4	-2.3	2.3	-2.4	-0.7	-2.0
Arm fat mass (right)	2.6	10.7	38.4	-0.4	0.9	-1.3	6.2	-1.7	-1.9	-6.2
Leg fat percentage (right)	2.6	9.3	33.1	-0.3	1.2	-0.4	5.3	-0.4	-3.4	-5.8
Medication for pain relief, constipation, heartburn	2.6	4.5	15.4	0.2	-2.3	0.7	-3.9	0.2	0.2	3.8
Illnesses of siblings: Diabetes	2.6	3.2	12.7	0.7	0.9	-0.3	2.8	-0.8	-1.8	-3.6
Leg fat percentage (left)	2.6	9.4	32.6	-0.3	1.3	-0.3	5.4	-0.4	-3.4	-5.7
Vascular/heart problems diagnosed by doctor	2.6	7.2	24.5	1.2	-0.4	-2.6	-3.9	-2.9	-1.2	5.0
BMI	2.5	14.7	51.6	0.6	1.5	-2.0	7.2	-2.5	-2.6	-6.9
Type 2 Diabetes (T2D) (2018)	2.5	4.7	18.1	0.0	4.3	0.5	2.5	0.5	-1.0	-3.4
Cardiovascular Disease	2.4	8.0	31.8	-1.3	1.4	1.5	4.7	1.9	0.6	-5.6
High blood pressure	2.4	6.6	21.7	-1.3	0.1	2.5	3.6	2.9	1.5	-4.7
Stomach or abdominal pain in last month	2.4	3.0	8.7	1.0	1.0	-1.7	2.5	-1.7	-1.0	-2.9
Financial difficulties in last 2 years	2.4	3.3	10.6	-0.2	1.6	-0.4	3.2	0.0	-1.5	-3.2
Prospective memory result	2.4	3.0	8.0	-0.7	-1.5	1.7	-2.8	1.7	1.4	2.4
Birth weight	2.4	5.2	16.5	-1.8	-2.6	0.9	-3.7	0.8	0.1	4.1
Knee pain experienced in last month	2.4	3.8	10.6	0.1	1.3	-0.0	2.9	0.1	-3.1	-3.3
Medication: Atenolol	2.3	2.9	8.6	0.6	2.9	-0.8	2.2	-0.6	1.7	-2.3
Whole body fat mass	2.3	9.6	35.8	-0.8	0.7	-1.0	5.9	-1.4	-1.5	-6.0
Leg fat mass (right)	2.3	9.1	33.4	-0.5	0.9	-1.1	5.7	-1.4	-1.7	-5.8
Leg fat mass (left)	2.3	9.1	32.9	-0.4	0.9	-1.2	5.7	-1.4	-1.7	-5.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.5	6.4	1.1	2.5	-1.1	2.4	-1.3	-0.1	-2.0
Cholesterol lowering medication	2.2	3.3	11.6	-0.2	3.4	-0.2	2.2	-0.2	-1.6	-2.6
Body Mass Index (BMI) (2010)	2.1	2.9	11.2	-1.2	0.0	0.3	3.2	0.3	-0.3	-3.4
Systolic blood pressure, automated reading	2.1	6.2	19.4	2.4	1.7	-1.6	4.2	-1.3	0.5	-4.4
Trunk fat mass	2.1	9.0	33.1	-0.5	0.5	-1.4	5.7	-1.7	-1.1	-5.8
Hypertension (Self-reported)	2.1	5.7	20.1	-1.0	0.3	2.2	3.4	2.6	1.4	-4.5
Back pain experienced in last month	2.1	3.0	10.2	1.2	-0.1	-0.4	2.0	-0.4	-3.2	-2.8
Number of treatments/medications taken	2.0	3.6	13.0	0.7	1.4	-1.4	3.4	-0.3	-0.2	-3.6
Angina	2.0	2.6	4.6	1.6	2.2	-1.8	1.8	-1.4	1.9	-1.3
Medication: Simvastatin	2.0	3.0	8.2	-0.1	2.3	-1.1	2.9	-1.1	-0.5	-2.8
Hip circumference	2.0	8.6	31.5	-0.1	-0.3	-1.6	5.6	-2.0	-0.3	-5.5
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	9.5	-1.5	-0.5	1.8	1.7	1.8	-3.1	-2.0
Commuting to job workplace: Public transport	2.0	2.4	8.8	0.4	-3.0	0.1	-2.3	1.2	-0.2	1.8
Smoking Status	1.9	4.6	23.5	0.3	1.8	0.4	2.3	0.0	-4.8	-2.2
Noisy workplace	1.9	2.3	7.9	0.9	0.1	-0.8	2.7	-0.4	-1.3	-2.8
Angina (self-reported)	1.9	2.5	5.2	1.5	2.3	-1.5	1.8	-1.2	2.1	-1.3
Average weekly champagne plus white wine intake	1.9	2.7	11.9	1.4	-1.1	-1.3	-1.0	-1.5	3.4	1.1
Basal cell carcinoma (self-reported)	1.9	2.2	8.1	1.5	2.9	-1.9	0.1	-1.8	-0.3	0.8
Weight	1.8	8.8	31.7	-0.3	-0.3	-1.7	5.6	-2.2	0.6	-5.5
Father’s age at death	1.8	2.5	6.8	-1.2	-1.9	0.9	-2.6	0.7	0.2	2.6
Comparative body size at age 10	1.8	4.9	14.7	-1.8	-1.4	1.5	2.6	1.4	-3.8	-2.9
Long-standing illness, disability or infirmity	1.8	2.8	12.6	0.4	1.1	-0.3	1.9	0.2	-3.5	-2.0
Commuting to job workplace: Walk	1.8	1.9	6.5	0.6	-2.5	-0.8	-1.6	-0.8	-1.0	1.8
Number of self-reported non-cancer illnesses	1.8	3.1	10.2	-0.2	1.9	0.0	3.0	0.4	-1.3	-3.2
Age at First Birth	1.7	2.5	5.7	1.9	-1.2	-2.1	-0.5	-1.7	2.4	1.2
Prostate Cancer	1.6	2.3	4.7	1.4	-0.1	-1.9	-1.9	-1.9	1.0	2.2
Ever used hormone-replacement therapy (HRT)	1.6	2.0	5.5	0.8	2.3	-1.4	1.4	-2.0	-1.1	-1.1
Diabetes diagnosed by doctor	1.6	2.7	8.9	0.2	2.8	0.3	2.2	0.4	-0.3	-3.0
Diastolic blood pressure, automated reading	1.6	4.8	19.1	1.2	2.3	-0.1	3.6	-0.0	0.2	-4.4
Loud music exposure frequency	1.5	1.6	7.4	-0.2	1.9	0.8	0.1	1.0	-2.7	-0.2
Wheeze or whistling in the chest in last year	1.5	2.6	8.1	-0.8	1.0	0.5	2.2	-0.1	-2.8	-2.5
Chest pain or discomfort	1.5	2.1	4.0	1.0	0.7	-1.8	1.9	-2.0	-1.1	-1.8
Leg pain on walking	1.5	1.9	7.5	1.1	0.2	-0.4	2.4	-0.4	0.3	-2.7
Medication: Gliclazide	1.5	1.8	4.2	-0.7	1.6	1.4	1.6	1.3	-0.7	-2.1
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.6	-0.6	1.7	1.0	1.5	1.1	-1.1	-2.1
Medication: Metformin	1.4	2.0	6.8	0.1	2.6	0.5	1.8	0.9	-0.4	-2.3
Current tobacco smoking	1.4	2.3	8.3	-0.4	0.8	0.9	1.8	1.0	-2.9	-2.2
Chronic bronchitis/emphysema (father)	1.4	1.7	5.6	0.6	-0.4	-2.4	1.0	-2.0	-1.0	-1.1
Diabetes (self-reported)	1.4	2.2	7.4	-0.1	2.7	0.5	1.9	0.3	0.2	-2.6
Pulse rate	1.4	2.3	9.5	-1.0	1.9	0.1	1.7	0.2	-3.1	-1.3
Medication: Blood pressure	1.4	2.5	8.0	0.5	1.3	-0.2	2.3	0.3	2.8	-2.2
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	5.2	0.3	-1.4	-0.5	-1.5	-0.7	2.3	1.7
Loneliness, isolation	1.4	2.0	7.1	-2.7	-2.2	1.3	-0.4	1.0	-1.0	0.3
Hearing aid user	1.4	1.6	3.3	1.1	1.8	-1.6	0.9	-1.5	-1.7	-0.3
Ever depressed for a whole week	1.4	1.7	5.2	1.5	-0.5	-1.2	2.3	-1.2	0.3	-1.7
Medication: Co-codamol	1.3	1.5	5.8	-0.5	0.2	0.1	2.0	0.1	-1.2	-2.4
Hand grip strength (right)	1.3	3.6	8.7	-2.9	-1.6	2.3	-2.2	2.1	-0.2	1.8
High blood pressure (mother)	1.3	1.8	6.7	-1.3	-0.3	2.6	-0.5	2.4	0.2	-0.5
Leg predicted mass (left)	1.3	6.7	19.8	-0.7	-0.5	-1.9	4.5	-2.5	2.9	-3.9
Time employed in main current job	1.3	1.5	3.9	0.5	1.2	-1.0	2.0	-0.5	1.6	-1.7
Qualifications: A levels/AS levels or equivalent	1.3	2.8	8.4	1.1	-2.0	-0.3	-2.2	0.4	1.9	2.9
Medication: Lansoprazole	1.3	1.5	4.2	0.4	2.0	-1.2	1.7	-0.8	-0.1	-1.7
Neck or shoulder pain in last month	1.3	1.9	8.0	-0.7	0.0	0.1	1.4	0.1	-2.8	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	4.7	-0.0	1.6	1.1	1.9	0.5	0.1	-2.2
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	6.3	-0.7	1.0	1.1	0.5	1.4	-2.5	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.1	-1.8	1.6	1.6	0.9	1.0	-0.9	-0.7
Supplements: Fish oil (including cod liver oil)	1.3	1.7	2.9	1.3	1.7	-0.6	1.6	-0.7	-1.6	-1.7
Leg fat-free mass (left)	1.2	6.6	19.7	-0.8	-0.5	-1.7	4.4	-2.3	2.9	-3.9
Townsend deprivation index at recruitment	1.2	1.7	5.2	-0.3	1.1	0.7	1.8	0.6	-1.7	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	5.7	-1.4	2.1	0.4	2.3	-0.7	-1.7	-2.4
Qualifications: CSEs or equivalent	1.2	1.5	5.3	-0.4	2.3	0.7	1.7	0.3	-0.8	-1.7
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	5.3	-1.0	1.1	0.1	2.3	0.5	-0.2	-2.1
Medication: Cholesterol lowering	1.2	1.9	6.8	1.0	0.9	-0.3	2.4	0.2	0.6	-2.6
Standing height	1.2	12.1	55.5	-1.0	-4.8	-1.2	-2.2	-2.0	7.5	2.7
Blood clot in the leg (DVT)	1.2	1.6	3.8	-2.0	0.6	1.9	0.0	1.4	-1.6	-0.1
Medication: Amlodipine	1.2	1.6	4.2	-0.4	-0.4	0.6	1.9	1.0	1.9	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.1	1.1	-0.2	-1.8	1.6	-1.5	-0.8	-1.1
Commuting to job workplace: Car/motor vehicle	1.2	1.3	4.3	0.5	2.1	-1.0	1.5	-1.2	-0.3	-1.2
Leg fat-free mass (right)	1.2	6.4	18.9	-0.6	-0.4	-1.8	4.3	-2.4	3.0	-3.6
Leg predicted mass (right)	1.2	6.3	18.8	-0.6	-0.4	-1.9	4.3	-2.4	3.0	-3.6
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.7	-1.9	0.5	1.9	0.2	1.4	-1.7	-0.4
Mouth/teeth dental problems: Dentures	1.1	1.8	6.5	1.4	0.4	-0.4	2.3	-0.7	0.2	-2.6
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.8	0.2	1.1	-0.2	1.8	-0.2	-1.5	-1.9
Age at first live birth	1.1	1.9	8.4	0.6	-1.6	-0.1	-1.0	-0.2	2.9	1.7
Medication: Aspirin	1.1	1.4	4.5	0.3	2.0	-0.2	1.6	0.4	0.3	-2.1
Qualifications: nursing, teaching	1.1	1.7	3.8	2.0	0.9	-1.6	-0.6	-1.3	1.6	1.4
Osteoarthritis (self-reported)	1.1	1.4	7.0	-1.1	-0.6	0.7	0.9	0.8	-2.6	-1.0
High cholesterol (Self-reported)	1.1	1.9	6.2	-0.4	1.1	0.8	2.1	1.2	-1.1	-2.5
Basal metabolic rate	1.1	5.9	16.3	-0.6	-1.4	-1.5	4.0	-2.1	2.8	-3.7
Number of operations (self-reported)	1.1	1.6	7.3	0.6	-0.1	0.7	1.5	0.6	-2.7	-1.4
Myopia	1.1	1.6	4.7	-1.1	-1.2	1.7	-1.1	2.2	0.7	0.7
Alcohol drinker status: Previous	1.1	1.2	3.8	0.2	0.7	-1.7	0.8	-1.3	-1.9	-0.1
Neuroticism (2016)	1.0	1.4	4.5	1.5	0.2	-1.2	1.4	-2.1	-0.2	-0.7
Rheumatoid Arthritis	1.0	1.4	4.4	1.1	0.3	-0.7	2.0	-0.9	0.1	-2.1
Systolic Blood Pressure	1.0	4.8	15.1	1.2	1.6	-0.8	3.6	-0.4	2.3	-3.9
Average weekly spirits intake	1.0	1.2	4.0	-0.6	-0.3	-0.2	1.9	0.7	1.0	-2.0
Sensitivity / hurt feelings	1.0	1.6	4.1	-0.7	-1.2	1.7	-1.0	1.4	2.0	1.2
Hearing difficulty/problems: Yes	1.0	1.6	2.9	0.7	1.1	-1.2	1.7	-1.5	-1.4	-1.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	1.4	1.2	-1.3	0.9	-1.2	0.7	-0.9
Vitamin and mineral supplements	1.0	1.3	3.8	-0.8	-1.2	1.0	-1.9	0.7	-1.0	1.4
Pack years adult smoking proportion	1.0	1.5	5.4	-0.2	1.3	-0.2	2.1	0.2	-0.2	-2.3
Impedance of leg (right)	1.0	4.8	17.6	-0.5	-1.0	1.8	-4.2	1.9	-0.7	3.5
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	7.1	-1.1	2.7	0.3	-0.5	-0.2	0.1	0.8
Multivitamins +/- minerals	1.0	1.3	3.9	0.8	0.2	-0.8	2.0	-0.6	1.1	-1.8
Sitting height	1.0	7.4	29.3	-0.6	-4.2	-1.5	-1.3	-2.1	5.4	1.8
Alcohol usually taken with meals	1.0	1.6	4.6	0.4	-1.5	0.1	-1.9	0.2	2.1	1.5
Had menopause	1.0	1.3	3.2	1.8	0.6	-1.8	1.0	-1.4	0.1	-0.6
Illnesses of mother	1.0	1.3	4.1	1.2	1.1	-2.0	0.9	-1.5	-0.2	-0.2
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	6.9	-0.2	0.9	0.2	-1.7	0.5	1.5	2.6
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.8	-1.0	-0.7	0.1	-2.0	-0.4	-1.5	2.2
Arm fat-free mass (right)	1.0	4.9	12.1	-0.5	-1.5	-1.5	3.5	-2.0	2.8	-3.2
Qualifications: College or University degree	1.0	3.0	9.2	-0.1	-0.8	-0.6	-2.3	-0.9	3.0	2.8
Arm predicted mass (right)	1.0	5.3	11.4	-0.3	-1.9	-1.6	3.4	-2.2	3.1	-3.1
Mineral and other dietary supplements	1.0	1.3	3.5	-1.9	-0.6	1.5	-1.2	1.1	0.7	1.1
Illnesses of father: None of the above (group 1)	1.0	1.2	4.9	0.5	-1.4	-0.2	-1.0	-0.2	1.1	2.2
Smoking status: Current	1.0	1.6	6.3	-0.2	0.8	0.5	1.4	0.6	-2.5	-1.7
Miserableness	1.0	1.8	7.9	-0.6	-0.6	0.4	1.9	-0.2	-2.8	-1.4
Wears glasses or contact lenses	1.0	1.1	4.8	0.9	-2.2	-0.6	0.4	-0.6	1.4	-0.6
Fasting Glucose	0.9	1.0	3.2	-1.4	-1.8	0.9	-1.0	1.1	0.2	-0.2
Taking other prescription medications	0.9	1.5	4.9	0.5	1.3	-1.1	2.2	-0.3	-0.5	-1.8
Impedance of leg (left)	0.9	4.6	15.8	-0.6	-0.6	1.7	-4.0	2.0	-1.1	3.5
Length of working week for main job	0.9	1.0	3.5	-0.1	-1.9	-0.2	0.6	-0.5	-1.9	-0.6
Medication: Paracetamol	0.9	1.5	4.5	0.6	-0.5	-1.4	2.1	-1.4	0.3	-1.8
Comparative height size at age 10	0.9	4.8	27.2	0.2	-2.5	-1.3	0.3	-1.8	5.2	0.5
Whole body fat-free mass	0.9	5.3	13.0	-0.6	-1.8	-1.5	3.3	-2.2	3.6	-2.8
Medication: Aspirin	0.9	1.2	3.4	-0.6	1.7	0.4	1.3	0.8	0.5	-1.8
Whole body water mass	0.9	5.4	11.8	-0.5	-1.7	-1.6	3.4	-2.3	3.4	-3.0
Eye problems/disorders: Glaucoma	0.9	1.0	2.1	-1.4	-1.5	0.4	-0.6	0.5	1.4	1.1
Medication: Blood pressure	0.9	1.6	5.1	-1.0	0.1	1.3	1.4	1.4	1.1	-2.3
Medication: Bendroflumethiazide	0.9	1.4	4.7	-1.5	-0.9	1.2	0.2	1.3	2.2	-0.7
Arm fat-free mass (left)	0.9	4.8	12.4	-0.5	-1.8	-1.4	3.5	-1.9	2.5	-3.2
Commuting to job workplace: Cycle	0.9	1.1	2.8	-1.4	-0.8	0.1	-1.6	-0.4	0.6	1.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	3.9	-0.5	0.6	0.6	2.0	0.7	-0.8	-1.7
Pack years of smoking	0.9	1.3	5.0	0.0	0.7	-0.3	2.1	0.0	0.4	-2.2
Arm predicted mass (left)	0.9	4.7	11.6	-0.2	-1.7	-1.5	3.4	-2.1	2.5	-3.2
Bipolar Disorder (2018)	0.8	1.3	4.4	1.0	0.8	-1.9	0.5	-2.1	0.7	-0.1
Intelligence (Savage-Jansen 2018)	0.8	2.6	5.5	-1.7	-2.0	0.9	-2.3	1.3	0.9	2.3
Alzheimer’s Disease (including proxy)	0.8	1.2	2.2	-1.4	-1.0	1.4	-0.5	1.4	-1.5	0.0
LDL Cholesterol	0.8	1.3	2.8	-0.7	0.0	1.0	1.5	1.1	-1.5	-1.7
Blood Red Count	0.8	7.9	34.0	2.3	0.6	3.3	2.8	2.0	-0.3	-5.8
Supplements: Zinc	0.8	0.8	2.9	-1.0	0.6	1.1	0.8	1.7	0.0	-0.8
Supplements: Glucosamine	0.8	1.0	2.6	0.5	-0.1	-1.1	1.3	-1.0	-1.6	-1.3
Trunk fat-free mass	0.8	4.5	16.1	-0.5	-2.6	-1.2	2.1	-1.9	4.0	-1.8
Number of live births	0.8	1.1	3.5	1.1	1.1	0.5	1.6	0.7	-0.1	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.5	-1.1	1.1	1.1	-0.1	1.6	-0.8	-0.4
Trunk predicted mass	0.8	4.6	16.4	-0.5	-2.7	-1.2	2.1	-1.9	4.0	-1.8
Breastfed as a baby	0.8	1.0	2.4	0.6	-0.0	1.2	-1.4	1.3	1.5	0.4
Hair/balding pattern: Pattern 4	0.8	1.8	6.2	-1.3	0.4	2.1	-0.8	2.5	1.1	0.6
Exposure to tobacco smoke outside home	0.8	1.1	2.9	1.7	0.8	-1.1	0.7	-1.4	-0.0	-1.1
Shortness of breath walking on level ground	0.8	0.9	5.4	-0.3	0.0	-0.4	0.5	-0.7	-2.3	-1.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.8	0.1	0.8	-0.1	1.5	-0.3	-1.2	-1.7
Medication: Ibuprofen	0.8	1.0	2.5	-1.2	0.5	0.5	1.4	1.0	-0.7	-1.6
Alcohol intake frequency.	0.8	1.8	9.5	-1.2	-0.3	1.1	-0.3	1.6	-3.1	-0.2
Medication for cholesterol	0.8	1.2	4.3	0.6	-0.4	-1.4	-1.2	-1.3	0.6	2.1
Ever smoked	0.8	1.4	7.2	1.1	1.3	-0.1	0.5	-0.8	-2.7	-0.1
Alzheimer’s Disease (in father)	0.7	0.7	3.0	-0.2	-0.6	0.7	0.7	0.7	-1.7	-1.0
Ulcerative Colitis	0.7	1.0	3.6	-0.8	-1.9	0.9	-0.5	1.0	0.4	1.2
Blood Platelet Count	0.7	7.9	36.4	-1.2	-2.0	2.6	1.5	2.4	-6.0	-2.5
Height	0.7	12.5	84.6	-0.2	-2.6	-1.2	-0.6	-2.3	9.2	1.4
Respiratory disease	0.7	1.5	7.6	-0.1	0.2	-0.7	0.9	-0.3	-2.8	-1.6
Chronotype (morning person)	0.7	1.6	6.9	-2.6	0.2	1.9	-0.1	1.3	0.6	-0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.7	-1.6	-0.5	1.4	1.1	1.3	-0.1	-0.7
Severe depression (siblings)	0.7	0.8	2.0	-0.4	-0.1	1.4	-0.3	1.4	-1.4	-0.0
Past tobacco smoking	0.7	1.4	5.5	-0.8	-2.4	-0.2	-1.0	0.5	1.8	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.4	-0.3	-1.6	0.9	1.3	0.7	-1.1	-1.3
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.6	0.4	-0.8	-0.7	1.6	-0.4	-1.1	-1.4
Birth weight of first child	0.7	1.3	4.2	-0.5	-2.1	0.6	-1.6	0.7	0.5	1.6
Glaucoma (self-reported)	0.7	0.8	2.6	-0.8	-1.6	0.3	-0.6	0.6	1.4	0.5
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.7	-1.5	-1.6	0.0	-0.2	0.2	-1.5	-0.2
Worry too long after embarrassment	0.7	1.2	6.9	0.7	-2.6	-0.1	-0.7	-0.3	0.1	1.1
Eye problems/disorders: None of the above	0.7	0.8	2.0	0.4	1.4	-0.6	1.3	-0.6	-0.2	-1.3
Pulse rate, automated reading	0.7	2.4	10.7	-0.4	0.7	-0.8	2.2	-0.7	-3.3	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.3	-1.0	1.5	-0.9	0.2	-0.8	-1.3	0.1
Illnesses of father: High blood pressure	0.7	0.9	2.6	-0.6	0.3	1.4	0.9	1.2	-0.2	-1.6
Fractured/broken bones in last 5 years	0.7	0.8	3.2	-1.5	1.8	0.1	0.6	0.1	-0.6	-0.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.5	0.8	-0.7	-1.0	1.6	-1.3	-0.3	-1.0
Impedance of whole body	0.7	3.7	14.1	-0.8	-0.4	1.2	-3.8	1.4	-0.2	3.4
Depressed Affect (Nagel 2018)	0.6	1.2	6.1	-0.3	-0.4	-0.9	0.9	-0.8	-2.5	-0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.2	-0.9	0.1	0.9	-1.8	0.7	1.5	1.8
HDL Cholesterol	0.6	0.9	2.2	1.5	0.0	-0.8	-1.1	-0.8	1.0	1.4
Neuroticism	0.6	1.4	4.7	0.2	0.5	-0.2	2.1	-0.2	-1.1	-2.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.5	-0.6	0.8	1.2	0.4	1.2	1.2	-0.7
Hearing difficulty/problems with background noise	0.6	0.9	3.7	0.9	0.3	-0.7	1.0	-0.9	-1.9	-0.9
Had other major operations	0.6	0.7	3.9	0.4	0.7	-0.2	0.7	-0.8	-2.0	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.2	-0.9	1.1	0.2	1.3	-1.1	-2.1	-1.4
Qualifications: None of the above	0.6	1.4	5.4	0.4	0.4	-0.7	1.4	-0.6	-2.3	-1.6
Impedance of arm (right)	0.6	2.8	10.2	-0.7	-0.2	1.0	-3.2	0.8	-0.2	3.1
Happiness	0.6	0.8	2.6	1.4	-0.2	-1.1	0.1	-0.4	1.6	-0.5
Exposure to tobacco smoke at home	0.6	0.7	2.4	-0.2	0.5	-0.7	1.0	-0.6	-1.6	-1.1
Heart disease (mother)	0.6	0.7	2.9	1.7	0.3	-0.7	0.6	-0.8	1.0	-0.5
Number of full sisters	0.6	0.8	2.5	-1.6	1.2	0.3	0.0	0.7	-1.3	-0.1
Supplements: Vitamin C	0.6	0.7	1.6	0.6	1.1	0.0	1.3	0.3	0.9	-1.1
Smoking status: Previous	0.6	0.8	3.3	0.1	1.8	0.7	0.5	-0.1	-1.6	0.1
Ever had bowel cancer screening	0.6	0.6	2.0	1.1	-0.1	-1.4	-0.1	-1.1	-0.8	0.2
Friendships satisfaction	0.6	0.7	3.2	1.8	1.1	-0.2	-0.2	-0.6	0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.6	1.3	1.2	-1.6	0.0	-2.1	-0.2	0.5
Medication: Atorvastatin	0.6	0.7	2.5	-0.4	1.6	1.1	0.3	1.1	-0.4	-0.6
Alcohol drinker status: Never	0.6	0.7	2.0	-0.6	-1.4	0.1	-1.1	-0.3	0.6	1.3
Irritability	0.6	1.0	2.6	1.1	-1.6	-0.8	0.5	-1.1	-1.3	0.1
Depression (Nagel 2018)	0.5	0.8	1.6	-1.0	0.9	0.4	1.1	0.3	-1.3	-1.1
HbA1C	0.5	0.5	1.8	1.4	1.0	0.5	0.0	0.4	-0.8	-0.3
Triglycerides	0.5	0.8	2.5	-1.6	0.0	1.2	0.4	1.2	-0.7	-0.5
Heel T-Score	0.5	4.4	11.5	-2.8	-2.4	0.6	-2.1	-0.6	-3.4	2.2
Relative age of first facial hair	0.5	0.9	3.0	1.3	0.1	-1.4	-0.5	-1.7	0.5	0.5
Medication for hormone replacement therapy	0.5	0.6	2.4	0.6	1.6	-0.7	0.4	-0.9	-0.5	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.7	-0.5	-0.2	0.3	1.2	0.2	-1.3	-1.3
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	2.0	-1.4	0.2	0.3	0.8	0.1	0.9	-0.8
Heart attack	0.5	0.6	1.8	0.4	-1.0	-0.6	1.3	-0.9	-0.2	-0.8
Allergy	0.5	1.0	3.1	1.3	0.3	-1.1	-0.3	-0.9	1.8	1.2
Worrier / anxious feelings	0.5	1.0	3.8	0.0	-1.9	0.6	-1.1	1.2	0.7	0.9
Depression (self-reported)	0.5	0.6	1.4	-0.6	-0.0	0.8	1.1	1.2	0.5	-0.7
Pulse wave reflection index	0.5	0.6	3.2	0.0	-1.8	1.0	-0.0	0.6	0.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.4	-0.8	-1.3	1.2	-0.3	1.5	-0.9	-0.1
Pulse wave peak to peak time	0.5	0.6	2.2	0.9	-0.2	-1.5	-0.5	-1.1	-0.1	0.6
Emphysema/chronic bronchitis	0.5	0.6	1.7	-1.2	-1.3	0.1	-0.2	0.2	-1.3	-0.1
Migraine (self-reported)	0.5	0.7	2.5	0.1	1.6	-0.9	0.8	-0.6	0.2	-0.9
Mean time to correctly identify matches	0.5	1.0	2.9	1.7	0.8	-1.2	0.5	-1.5	0.5	-0.8
Eye problems/disorders: Cataract	0.5	0.5	2.5	-0.3	-1.6	-0.0	-0.9	0.2	0.1	0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	4.3	-0.2	1.3	0.3	0.3	0.5	-2.1	-0.4
Medication: Paracetamol	0.5	0.8	1.7	0.7	-0.3	-1.2	1.3	-1.0	0.6	-1.2
Bipolar Disorder or Schizophrenia	0.4	1.1	4.8	0.8	0.6	-1.1	0.5	-1.1	2.2	-0.2
Primary Biliary Cirrhosis	0.4	0.5	1.6	-0.7	-1.2	0.7	0.5	0.5	-0.5	-0.9
Hypothyroidism (self reported)	0.4	0.8	2.4	-0.8	-1.4	1.0	-0.1	1.5	-0.9	-0.4
Fed-up feelings	0.4	0.7	2.2	0.0	-0.6	-0.8	0.9	-1.1	-1.5	-0.5
Mouth/teeth dental problems	0.4	0.7	2.1	-0.7	-0.6	-0.3	-0.8	-0.4	1.2	1.5
Medication: Ramipril	0.4	0.5	2.2	-0.4	0.8	1.5	0.2	0.7	0.3	-0.1
Fluid intelligence score	0.4	0.8	2.6	-0.4	0.1	-0.1	-1.1	-0.5	1.5	1.6
Pulse wave Arterial Stiffness index	0.4	0.4	1.6	-0.7	0.1	1.2	0.5	0.9	0.6	-0.5
Impedance of arm (left)	0.4	1.7	7.0	-0.5	-0.1	0.6	-2.6	0.7	-0.1	2.4
Tense / ‘highly strung’	0.4	0.6	3.0	0.4	0.6	-0.0	1.0	0.3	1.7	-0.7
Headache pain in last month	0.4	0.7	3.6	-0.4	0.9	-0.4	0.5	-0.4	-1.9	-0.7
Forced vital capacity (FVC), Best measure	0.4	1.3	3.6	-0.5	-0.8	-1.3	-0.9	-1.9	1.4	1.3
Health satisfaction	0.4	0.5	1.3	-0.2	0.7	-0.8	1.0	-0.6	-0.6	-1.1
Medication: Allopurinol	0.4	0.5	1.9	-0.3	0.2	0.2	-1.2	-0.1	0.9	1.4
Medication: Omeprazole	0.4	0.5	2.0	-0.1	0.2	0.5	1.4	0.4	-0.3	-1.1
Had major operations	0.4	0.5	1.3	0.6	0.6	0.1	1.0	-0.2	-1.2	-1.0
Age at last live birth	0.4	0.6	2.4	0.7	-1.5	0.5	0.1	0.4	1.0	0.2
Ever taken oral contraceptive pill	0.4	0.5	0.9	-0.8	-0.0	0.9	-0.8	1.0	-0.7	0.5
Financial situation satisfaction	0.4	0.5	1.6	0.4	1.0	0.2	0.4	0.8	-1.2	-0.5
Medication: Lisinopril	0.4	0.5	1.6	0.8	-0.8	-0.6	-0.2	0.0	1.2	-0.7
Risk taking	0.4	0.6	3.7	-0.0	0.0	-0.9	0.3	-0.6	-1.9	-0.2
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.5	0.5	-0.3	-0.2	-1.2	0.1	-1.2	0.6
Supplements: Calcium	0.4	0.5	1.6	-0.3	0.4	-0.2	-1.0	0.6	0.7	1.3
Schizophrenia (2018)	0.3	0.6	4.8	0.2	0.2	0.0	0.3	0.3	2.2	-0.2
Worry (Nagel 2018)	0.3	0.7	2.0	0.2	0.8	0.9	0.6	1.4	0.8	-0.9
Ulcerative Colitis (UC)	0.3	0.6	1.6	-0.5	-1.3	0.9	-0.4	0.8	-0.2	1.1
Reaction Time	0.3	0.6	1.8	0.8	0.4	-0.7	0.5	-1.1	1.4	-0.7
Mean Putamen Volume	0.3	0.3	0.5	-0.0	0.7	-0.3	-0.7	-0.5	-0.7	0.7
Lupus	0.3	0.4	1.8	-0.3	0.2	-1.3	-0.3	-1.1	0.3	0.3
Schizophrenia (2014)	0.3	0.6	2.9	-0.3	0.7	0.7	-0.2	0.8	1.7	0.2
Lung FVC	0.3	1.6	9.8	0.8	0.7	-0.9	-0.2	-0.5	-3.1	0.7
Hand grip strength (left)	0.3	0.8	2.0	-1.4	-1.3	0.7	-0.8	0.2	-0.1	1.1
Diabetes (mother)	0.3	0.4	1.5	0.2	0.2	1.0	0.5	0.1	-0.8	-1.2
Relative age voice broke	0.3	0.5	1.3	0.8	-1.2	-0.1	-0.7	-0.8	0.6	0.7
Medication: Levothyroxine sodium	0.3	0.6	1.7	-0.1	-0.6	0.9	0.3	1.1	-1.3	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.9	-0.4	-0.1	0.6	-0.4	1.1	-0.4
Forced vital capacity (FVC)	0.3	1.1	2.2	-1.2	-0.6	-0.7	-1.1	-1.2	1.5	1.5
Pain all over the body in last month	0.3	0.3	0.8	-0.1	0.3	0.6	0.5	0.5	-0.9	-0.9
Alcohol intake versus 10 years previously	0.3	0.4	2.5	-0.0	-0.3	-0.6	-0.4	-0.2	-1.6	0.6
Hair/balding pattern: Pattern 3	0.3	0.5	1.4	0.4	-0.3	0.9	-0.7	1.2	0.9	0.3
Asthma	0.3	0.6	3.5	-0.2	-0.1	-0.3	0.4	-0.2	-1.9	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	4.8	0.2	-0.7	-1.6	0.0	-2.2	0.9	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.5	0.3	-0.7	0.6	1.2	0.5	-1.0	-0.6
Peak expiratory flow (PEF)	0.3	0.8	1.9	0.0	0.1	-1.1	1.1	-1.4	0.9	-1.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.4	0.3	-1.2	-0.3	-0.9	-0.4	0.0	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.8	-0.0	-0.0	0.0	1.3	-0.3	-0.1	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	2.0	0.0	0.2	-0.3	1.0	-0.3	-1.4	-0.5
Average weekly red wine intake	0.3	0.4	1.2	-0.3	-0.7	1.1	0.2	1.0	-0.4	-0.4
Mood swings	0.3	0.6	1.8	-0.2	-1.3	-0.4	1.0	-0.4	-0.9	-0.6
Asthma (self-reported)	0.3	0.7	3.7	-0.2	-0.2	-0.0	0.5	0.2	-1.9	-1.2
Osteoporosis (self-reported)	0.3	0.3	1.4	-0.1	0.1	0.1	-0.7	1.2	-0.8	0.3
Guilty feelings	0.3	0.5	1.1	0.4	0.2	0.7	1.1	0.7	-0.9	-1.0
Age started oral contraceptive pill	0.3	0.4	0.8	0.9	-0.5	-0.9	-0.5	-0.5	0.3	0.8
Breast Cancer	0.2	0.5	2.2	-0.7	1.5	0.4	-0.0	0.4	-0.9	-0.1
Blood White Count	0.2	1.4	5.0	-0.9	1.2	0.5	1.6	0.4	-0.9	-2.2
Waist Hip Ratio (WHR)	0.2	1.1	3.6	0.9	0.6	0.0	1.0	0.2	1.7	-1.9
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.1	-1.0	-0.2	1.1	-0.0	1.0	-0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.1	0.3	0.1	-0.3	-0.1	-0.5	-1.0	0.2
Neuroticism score	0.2	0.5	1.2	-0.2	-1.1	0.5	1.1	0.4	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.6	-0.7	-0.6	-0.8	-0.4	-1.3	1.0	0.7
Lung cancer (father)	0.2	0.2	1.2	0.2	-1.1	0.0	0.4	-0.4	-0.1	-0.5
Number of children fathered	0.2	0.2	1.0	-0.1	-0.1	-0.1	-0.2	-0.5	-1.0	0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.8	-0.3	0.3	0.3	0.9	0.3	-0.1	-0.7
Family relationship satisfaction	0.2	0.2	0.5	-0.1	-0.5	0.5	-0.7	0.7	0.1	0.5
Illnesses of father: Heart disease	0.2	0.2	0.6	0.4	0.5	0.5	0.4	0.4	0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.3	0.8	-0.7	-0.6	-0.1	0.6	-0.7	0.9	-0.5
Neuroticism (Nagel 2018)	0.1	0.3	1.6	0.3	-0.4	-0.1	0.4	0.2	-1.3	-0.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.7	-0.8	-0.1	0.6	-0.1	0.2	0.3	-0.1
Crohns Disease (2017)	0.1	0.1	0.5	-0.2	0.7	0.3	0.3	0.4	-0.4	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.4	-0.2	0.8	0.1	0.7	-0.1	0.4
Ovarian Cancer	0.1	0.2	1.0	0.4	0.5	-0.1	0.1	0.1	1.0	0.2
Crohns Disease (2012)	0.1	0.1	0.4	0.4	-0.4	-0.2	0.6	0.1	0.3	-0.5
Blood Eosinophil Count	0.1	1.1	5.9	0.1	0.6	1.3	-0.5	0.6	2.4	0.2
Allergy or Eczema	0.1	0.4	2.1	-0.1	-1.4	0.3	-0.6	0.5	0.2	0.4
Lung FEV1/FVC ratio	0.1	0.5	2.7	0.3	-1.7	-0.4	0.1	-0.5	0.8	-0.3
Hair Pigment	0.1	2.0	6.2	-0.4	1.0	0.6	2.2	0.5	1.6	-2.5
Tanning	0.1	1.6	4.6	1.4	-0.8	-1.8	-0.4	-2.1	1.2	0.9
Average weekly fortified wine intake	0.1	0.1	0.3	0.4	0.5	-0.1	-0.5	0.3	0.2	-0.1
Nervous feelings	0.1	0.1	0.6	0.3	-0.0	-0.0	0.0	0.3	0.7	0.2
Gout (self-reported)	0.1	0.2	0.4	-0.6	0.7	-0.2	-0.2	-0.3	0.5	0.5
Suffer from ‘nerves’	0.1	0.1	0.3	0.3	-0.6	0.2	0.2	0.3	-0.5	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.5	-0.5	-0.2	0.3	-0.3	0.0	-0.5	0.7
Breast cancer (self-reported)	0.1	0.2	1.1	0.2	-1.0	-0.1	-0.1	-0.4	0.2	0.1
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.5	0.2	-0.4	0.6	-0.4	-0.7	-0.5
Schizophrenia vs Biploar Disorder	0.0	0.0	0.3	-0.6	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.2	0.0	-0.3	0.2	-0.2	0.1	0.1

Hub : Genes

PDIA2

Models

Trait associations