TWAS hub - LOC100134368

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0291	0.0162	5.1e-03	-0.002	0.005	0.009	NA	0.000	9.7e-01	7.9e-02	2.8e-02	NA	3.3e-01
2	TCGA	Lung Adenocarcinoma	0.0508	0.0261	2.7e-03	0.000	0.018	0.028	NA	0.001	2.9e-01	2.9e-03	2.5e-04	NA	2.2e-01
3	TCGA	Lung Squamous Cell Carcinoma	0.0389	0.0201	1.9e-03	0.014	0.024	0.030	NA	0.021	8.0e-03	8.5e-04	2.4e-04	NA	1.6e-03
4	TCGA	Pheochromocytoma and Paraganglioma	0.0800	0.0420	2.8e-03	0.070	0.061	0.051	NA	0.052	9.5e-04	1.9e-03	4.3e-03	NA	3.9e-03
5	TCGA	Prostate Adenocarcinoma	0.0492	0.0248	3.6e-04	0.004	0.043	0.027	NA	0.013	9.9e-02	2.5e-05	7.6e-04	NA	1.5e-02
6	TCGA	Thyroid Carcinoma	0.0580	0.0260	1.1e-05	0.049	0.067	0.058	NA	0.056	1.4e-05	3.9e-07	2.5e-06	NA	3.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Length of working week for main job	10.9	12.1	13.8	-3.3	-3.3	-3.7	-3.7	-3.2	-3.6
Medication: Ibuprofen (e.g. Nurofen)	8.9	11.3	16.5	-2.5	-3.8	-4.1	-3.3	-2.3	-3.7
Hip circumference	8.5	36.8	45.8	-6.8	-5.9	-5.3	-5.7	-6.6	-6.0
Waist circumference	8.3	30.4	37.1	-5.8	-4.3	-5.0	-6.0	-5.7	-6.1
Arm fat mass (left)	8.1	33.2	44.6	-6.6	-5.1	-4.2	-5.4	-6.7	-6.2
Arm fat mass (right)	7.5	30.9	41.1	-6.4	-5.0	-4.2	-5.2	-6.4	-5.8
Weight	7.3	36.0	47.2	-6.9	-6.3	-4.9	-5.4	-6.7	-5.6
Body mass index (BMI)	7.0	29.7	39.5	-6.3	-4.4	-4.0	-5.2	-6.2	-6.2
Medication: Ibuprofen	7.0	8.4	14.2	-1.7	-3.3	-3.8	-3.1	-1.6	-3.2
BMI	6.8	39.3	58.7	-7.7	-5.5	-4.6	-5.8	-6.9	-6.6
Whole body fat mass	6.7	28.0	41.2	-6.2	-4.7	-3.8	-4.7	-6.4	-5.5
Leg fat mass (right)	6.5	25.2	34.8	-5.7	-4.5	-3.8	-4.6	-5.9	-5.3
Commuting to job workplace: Public transport	6.5	7.8	10.5	3.2	1.1	3.2	3.2	2.5	2.9
Arm fat percentage (left)	6.1	24.4	35.6	-5.6	-3.8	-3.2	-4.6	-6.0	-5.8
Trunk fat mass	6.0	25.8	39.6	-5.8	-4.7	-3.6	-4.4	-6.3	-5.1
Leg fat mass (left)	6.0	23.3	33.4	-5.6	-4.3	-3.6	-4.4	-5.8	-5.1
Ever depressed for a whole week	5.6	6.9	13.5	-2.9	-0.9	-2.7	-3.7	-1.5	-3.0
Leg fat-free mass (left)	5.5	29.0	41.3	-6.4	-5.9	-4.6	-4.7	-5.9	-4.5
Leg predicted mass (left)	5.5	29.1	41.5	-6.4	-5.9	-4.7	-4.8	-5.8	-4.5
Arm fat-free mass (right)	5.4	27.5	39.3	-6.3	-5.8	-4.4	-4.8	-5.5	-4.3
Arm predicted mass (right)	5.4	27.4	38.6	-6.2	-6.0	-4.5	-4.8	-5.3	-4.3
Arm fat percentage (right)	5.3	21.1	31.1	-5.2	-3.6	-3.1	-4.2	-5.6	-5.3
Basal metabolic rate	5.3	29.3	40.8	-6.4	-6.1	-4.6	-4.9	-5.6	-4.5
Number of full brothers	5.1	6.5	11.0	-1.8	-1.9	-3.3	-2.9	-1.8	-3.1
Leg fat-free mass (right)	4.9	26.1	38.3	-6.2	-5.5	-4.5	-4.5	-5.5	-4.2
Leg predicted mass (right)	4.8	25.4	37.6	-6.1	-5.5	-4.4	-4.4	-5.4	-4.1
Arm fat-free mass (left)	4.8	24.6	34.6	-5.9	-5.5	-4.3	-4.5	-5.2	-4.1
Arm predicted mass (left)	4.8	24.2	34.8	-5.9	-5.4	-4.2	-4.5	-5.2	-4.0
Body fat percentage	4.6	18.2	31.5	-5.0	-3.3	-2.5	-3.6	-5.6	-4.8
Whole body water mass	4.6	26.1	37.0	-6.1	-5.9	-4.5	-4.7	-5.2	-4.0
Medication: Omeprazole	4.5	5.4	12.3	-2.0	-0.4	-2.5	-3.5	-1.8	-2.5
Whole body fat-free mass	4.5	25.8	36.5	-6.0	-5.8	-4.5	-4.8	-5.1	-4.0
Blood Red Count	4.4	43.0	69.7	-5.5	-4.6	-7.2	-8.3	-5.1	-7.6
Trunk fat percentage	4.4	17.6	31.1	-4.9	-3.2	-2.6	-3.6	-5.6	-4.6
Impedance of leg (left)	4.4	21.4	28.7	5.4	4.3	4.3	4.8	4.0	4.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.4	5.2	11.2	-2.9	-0.8	-0.9	-1.6	-3.3	-2.7
Number of incorrect matches in round	4.2	7.0	16.2	-1.8	-1.7	-4.0	-3.8	-0.3	-2.4
Loud music exposure frequency	4.2	4.6	8.5	1.2	2.6	2.9	2.6	0.6	1.9
Ever had stillbirth, spontaneous miscarriage or termination	4.2	4.5	7.7	-1.9	-0.5	-2.4	-2.8	-1.8	-2.6
Leg fat percentage (right)	3.9	14.0	22.2	-4.1	-2.7	-2.4	-3.6	-4.7	-4.4
Trunk predicted mass	3.8	21.6	32.4	-5.4	-5.7	-4.1	-4.5	-4.3	-3.6
Impedance of leg (right)	3.7	17.9	25.5	5.0	3.7	3.8	4.3	3.8	4.5
Medication: Omeprazole (e.g. Zanprol)	3.7	4.5	10.5	-1.5	-0.5	-2.2	-3.2	-1.6	-2.6
Heel bone mineral density (BMD) T-score, automated (left)	3.6	8.1	18.5	-4.1	-3.0	0.5	-0.1	-4.3	-2.1
Trunk fat-free mass	3.6	20.9	31.5	-5.3	-5.6	-4.0	-4.4	-4.2	-3.5
Comparative body size at age 10	3.6	10.1	18.3	-3.4	-3.3	-2.2	-1.9	-4.3	-3.2
Leg fat percentage (left)	3.6	13.0	21.3	-4.0	-2.5	-2.1	-3.3	-4.6	-4.3
Hearing difficulty/problems: Yes	3.5	5.4	8.7	-2.9	-2.1	-1.6	-2.5	-2.3	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.5	4.1	10.6	-1.6	0.6	-2.2	-3.3	-1.5	-2.1
Qualifications: O levels/GCSEs or equivalent	3.4	5.4	9.0	2.2	1.8	2.2	2.9	1.5	3.0
Impedance of whole body	3.4	17.3	23.5	4.8	3.8	3.8	4.5	3.4	4.4
Number of live births	3.3	4.7	7.8	-1.8	-1.5	-2.3	-2.8	-1.5	-2.7
Medication for pain relief, constipation, heartburn	3.3	5.6	9.7	1.9	-0.2	2.4	3.1	2.2	3.1
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.9	13.1	-3.6	-3.6	-0.0	0.5	-3.6	-1.5
Breast cancer (self-reported)	3.0	3.5	6.0	-1.9	-2.5	-1.7	-1.3	-1.9	-1.8
Tinnitus: Yes, now most or all of the time	2.9	3.4	6.0	-1.8	0.1	-1.4	-2.0	-2.3	-2.5
Body Mass Index (BMI) (2010)	2.8	3.8	7.9	-2.5	-1.2	0.0	-1.8	-2.8	-2.0
Pain type(s) experienced in last month: Hip pain	2.8	3.6	7.1	-1.5	-1.3	-1.8	-1.7	-2.1	-2.7
Basal cell carcinoma (self-reported)	2.8	3.3	8.9	1.8	3.0	0.9	1.0	1.7	1.8
Falls in the last year	2.6	3.6	9.3	-1.0	-0.8	-3.1	-2.5	-0.6	-2.0
Prostate Cancer	2.5	3.6	7.8	2.0	1.5	0.1	1.3	2.8	2.4
Illnesses of siblings: Diabetes	2.5	3.0	5.2	-2.2	-0.2	-1.4	-1.7	-2.3	-1.8
Average weekly red wine intake	2.5	3.6	6.1	-1.9	-1.3	-2.1	-1.8	-2.5	-1.7
Ever taken oral contraceptive pill	2.5	2.8	6.0	1.2	1.1	2.4	2.1	1.0	1.6
Financial difficulties in last 2 years	2.4	3.2	6.3	-1.8	-0.9	-1.1	-2.2	-1.6	-2.5
Noisy workplace	2.4	3.0	4.9	-1.6	-0.5	-1.9	-2.1	-1.4	-2.2
Mother’s age at death	2.4	3.1	5.5	2.1	1.3	0.7	1.4	2.1	2.3
Medication: Simvastatin	2.3	3.3	7.5	-2.6	0.3	0.4	-1.7	-2.7	-1.6
Impedance of arm (right)	2.3	10.6	15.9	4.0	2.7	2.4	3.7	2.8	3.6
Pain experienced in last month	2.3	3.8	7.9	1.6	0.6	1.5	2.1	2.3	2.8
Reaction Time	2.0	3.8	5.7	-2.4	-1.7	-0.7	-2.4	-1.9	-2.1
Heel T-Score	1.9	14.9	44.1	-3.2	-6.6	2.1	3.5	-4.2	1.2
Maternal smoking around birth	1.8	2.7	6.6	-2.6	0.1	-0.9	-1.3	-2.2	-1.5
Qualifications: A levels/AS levels or equivalent	1.8	4.1	6.8	2.6	1.1	1.6	1.9	2.0	2.5
Impedance of arm (left)	1.8	8.2	12.3	3.5	2.6	2.5	3.0	2.4	3.0
Shortness of breath walking on level ground	1.8	2.2	3.6	-1.8	-0.2	-1.9	-1.7	-1.2	-1.3
Commuting to job workplace: Car/motor vehicle	1.8	2.1	3.4	-1.5	-1.0	-1.7	-1.6	-0.6	-1.9
Vascular/heart problems diagnosed by doctor	1.8	4.8	11.5	2.2	0.5	0.6	2.6	2.3	3.4
HDL Cholesterol	1.7	2.8	6.5	2.2	1.1	0.0	1.2	2.5	1.8
Tense / ‘highly strung’	1.7	2.9	6.2	2.1	2.5	0.4	0.8	2.1	1.1
Commuting to job workplace: Walk	1.7	1.8	4.0	1.3	0.0	1.5	1.4	0.9	2.0
High cholesterol (Self-reported)	1.7	3.1	6.1	-1.8	0.2	0.5	-2.0	-2.3	-2.5
Ever had prostate specific antigen (PSA) test	1.7	1.9	7.0	0.1	-0.2	-1.1	-2.6	0.6	-1.7
Age at First Birth	1.6	2.4	4.4	2.1	0.5	0.5	1.8	1.6	2.0
Age when periods started (menarche)	1.6	3.8	7.9	2.6	1.0	2.2	1.2	2.8	0.9
Prospective memory result	1.6	1.9	3.6	1.6	0.5	1.6	1.4	1.9	0.9
Neck or shoulder pain in last month	1.6	2.3	4.1	-1.9	-1.1	-0.1	-1.4	-2.0	-1.7
Loneliness, isolation	1.6	2.2	3.6	-1.9	-1.7	-0.9	-1.5	-1.3	-1.4
Back pain experienced in last month	1.6	2.4	4.9	-2.0	-0.8	-0.2	-1.1	-2.2	-1.8
Supplements: Calcium	1.6	1.7	5.1	1.6	2.3	0.4	0.8	0.9	1.0
Systolic blood pressure, automated reading	1.5	4.3	9.2	-1.8	-1.6	-1.6	-2.6	-1.3	-3.0
High blood pressure	1.5	4.2	9.9	-1.8	-0.8	-1.1	-2.4	-2.1	-3.1
Birth weight	1.5	3.2	7.0	1.6	1.7	0.9	1.8	1.6	2.6
Osteoporosis (self-reported)	1.5	1.9	5.6	1.7	2.4	0.0	0.1	1.6	0.4
Risk taking	1.5	2.1	4.8	-0.8	-0.4	-2.2	-2.2	-0.8	-1.3
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.3	-1.2	-0.7	-1.3	-1.5	-0.9	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	6.1	-1.0	-1.0	-1.2	-1.8	-0.4	-2.5
Illnesses of siblings	1.4	2.0	4.4	1.6	-0.5	-0.4	1.6	1.3	2.1
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	5.2	-1.2	-1.1	-1.3	-1.4	-1.6	-2.3
Taking other prescription medications	1.3	2.0	5.9	-0.1	1.2	-1.6	-2.4	0.0	-1.4
High blood pressure (siblings)	1.3	1.9	4.0	-1.5	0.3	0.4	-1.5	-1.6	-2.0
Chest pain or discomfort	1.3	1.8	3.9	-1.4	-0.3	-1.2	-2.0	-1.1	-1.5
Leg pain on walking	1.3	1.6	2.7	-0.7	0.9	-1.2	-1.6	-1.3	-1.4
Illnesses of father: None of the above (group 1)	1.3	1.6	4.2	0.8	0.6	0.5	0.9	2.0	1.8
Miserableness	1.3	2.3	4.9	-1.9	-1.8	-0.4	-0.2	-2.2	-1.2
Neuroticism (2016)	1.2	1.7	3.0	-1.4	-1.7	-1.3	-0.9	-1.2	-1.1
Cardiovascular Disease	1.2	4.0	7.8	-2.2	-0.2	-0.1	-2.0	-2.7	-2.8
Chronotype (morning person)	1.2	2.7	4.2	-1.8	-2.0	-1.3	-1.9	0.0	-1.8
Number of treatments/medications taken	1.2	2.1	5.2	-0.5	1.8	-1.0	-2.3	-0.5	-1.7
Wheeze or whistling in the chest in last year	1.2	2.1	3.9	-1.6	-0.6	-0.8	-1.3	-2.0	-1.9
Osteoarthritis (self-reported)	1.2	1.6	2.4	-1.0	-1.5	-1.2	-1.3	-0.7	-1.6
Number of self-reported non-cancer illnesses	1.2	2.1	4.0	-1.2	1.2	0.2	-1.8	-1.5	-2.0
Financial situation satisfaction	1.2	1.5	2.9	1.0	1.5	1.7	0.8	1.4	0.6
Cholesterol lowering medication	1.2	1.7	3.6	-1.4	0.5	0.2	-1.2	-1.9	-1.8
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.0	-1.3	-0.1	-1.3	-1.5	-1.7	-1.0
Alzheimer’s Disease (including proxy)	1.1	1.6	6.3	-0.0	0.3	2.5	1.6	-0.7	0.2
Supplements: Zinc	1.1	1.2	3.5	1.4	1.9	0.5	0.1	1.2	0.1
Medication: Co-codamol	1.1	1.3	1.9	-1.4	-0.3	-1.2	-1.1	-1.1	-1.4
Exposure to tobacco smoke outside home	1.1	1.5	3.2	1.4	1.8	-0.1	1.2	1.0	1.2
Average weekly beer plus cider intake	1.1	1.6	5.4	-0.5	-2.3	-1.4	-0.7	-0.5	-1.2
Unable to work because of sickness or disability	1.1	1.4	2.9	-0.9	0.5	-0.7	-1.7	-0.9	-1.7
Rheumatoid Arthritis	1.0	1.4	3.2	-0.9	-0.1	1.8	1.2	-1.8	-0.1
Smoking Status	1.0	2.5	5.1	-1.8	0.5	-0.6	-1.8	-1.7	-2.3
Had other major operations	1.0	1.2	2.7	-1.4	0.0	-0.8	-1.6	-1.3	-0.6
Heart attack	1.0	1.2	3.0	-1.2	-0.3	-1.1	-1.1	-1.7	-0.8
Time employed in main current job	1.0	1.2	3.8	-0.6	1.0	-0.6	-2.0	0.3	-1.2
Alcohol intake versus 10 years previously	1.0	1.5	2.6	1.4	-0.4	1.2	1.6	1.1	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	3.0	0.2	1.7	1.6	0.8	-0.3	0.7
Mouth/teeth dental problems: Dentures	1.0	1.6	3.7	-1.2	0.2	-1.0	-1.9	-1.0	-1.7
Gout (self-reported)	1.0	1.4	5.9	-0.7	0.2	2.4	1.1	-0.7	0.3
Age at first live birth	1.0	1.8	3.2	1.6	-0.3	1.1	1.4	1.8	1.4
Medication: Aspirin	1.0	1.3	2.2	-1.0	1.4	0.5	-1.1	-1.0	-1.5
Medication: Blood pressure	1.0	1.9	3.4	-1.4	-0.9	-1.0	-1.2	-1.6	-1.8
Heart disease (siblings)	1.0	1.2	4.1	-1.1	-0.2	0.2	-0.8	-1.2	-2.0
Alcohol drinker status: Previous	1.0	1.2	2.4	0.8	1.4	1.0	0.6	0.9	1.6
Fasting Glucose	0.9	1.1	2.5	-0.2	-1.2	1.6	1.2	0.6	0.6
Stomach or abdominal pain in last month	0.9	1.1	3.6	-0.6	0.2	-1.2	-1.9	-0.2	-1.0
Medication: Atenolol	0.9	1.1	5.9	0.1	2.4	0.5	-0.7	-0.4	0.0
Chronic bronchitis/emphysema (father)	0.9	1.0	3.4	-0.9	-0.7	-1.8	-0.7	-0.9	-0.5
Had menopause	0.9	1.1	2.7	-1.2	0.5	0.1	-1.6	-1.0	-1.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.2	3.5	-1.2	0.5	-0.3	-1.9	-0.3	-1.3
Pulse wave Arterial Stiffness index	0.9	1.0	1.7	-1.3	0.2	-0.8	-1.3	-0.6	-1.3
Mean time to correctly identify matches	0.9	1.8	2.7	-1.5	-0.9	0.2	-1.6	-1.4	-1.6
Hypertension (Self-reported)	0.9	2.6	6.3	-1.2	-0.1	-0.8	-2.0	-1.8	-2.5
Eye problems/disorders: Glaucoma	0.9	1.1	2.6	0.7	1.6	1.0	0.3	1.3	0.8
Number of operations (self-reported)	0.9	1.4	2.8	-1.6	-0.2	0.6	-0.6	-1.7	-1.4
Lung FVC	0.8	4.0	5.8	1.1	2.1	2.4	2.2	1.8	2.1
Angina	0.8	1.1	5.0	0.1	2.2	1.0	0.3	-0.3	0.5
Current tobacco smoking	0.8	1.2	2.4	-1.0	-0.1	-1.0	-1.5	-0.7	-1.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	4.7	0.1	2.2	-0.1	-0.8	-0.0	-0.5
Medication: Paracetamol	0.8	1.3	2.8	-1.0	-0.1	-1.4	-1.7	0.3	-1.3
Angina (self-reported)	0.8	1.1	5.2	0.1	2.3	1.0	0.2	-0.3	0.4
Medication: Aspirin	0.8	1.1	2.5	-0.8	1.6	0.6	-0.9	-0.8	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.1	-1.6	-2.0	0.1	-0.2	-1.8	0.2
Hearing aid user	0.8	0.9	2.0	-0.8	-0.0	-1.4	-1.4	-0.4	-0.8
Irritability	0.8	1.3	3.3	0.4	-0.1	1.5	1.8	0.1	1.4
Breast Cancer	0.7	1.8	2.8	-0.8	-1.4	-1.7	-1.5	-1.0	-1.4
Mean Putamen Volume	0.7	0.8	2.0	0.8	1.3	-0.2	-0.7	1.4	0.3
Lupus	0.7	1.1	3.2	0.5	0.5	1.8	0.3	0.9	1.4
Triglycerides	0.7	1.2	2.4	-1.3	-1.6	0.0	0.2	-1.6	-0.8
Height	0.7	13.9	43.8	-3.4	-6.6	-3.3	-2.2	-3.4	-1.1
Neuroticism	0.7	1.7	3.2	-1.2	-0.9	-1.8	-1.1	-1.4	-1.3
Multivitamins +/- minerals	0.7	0.9	4.0	0.8	2.0	0.5	0.0	0.4	0.4
Sitting height	0.7	4.7	15.7	-2.2	-4.0	-2.0	-0.1	-1.5	1.3
Father’s age at death	0.7	1.0	3.7	-0.1	-1.9	-1.3	-0.6	-0.2	-0.3
Standing height	0.7	6.5	22.8	-2.2	-4.8	-2.5	-1.3	-1.8	0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.7	-0.8	-1.9	0.8	0.5	-0.6	-0.2
Worry too long after embarrassment	0.7	1.2	5.4	-0.6	-2.3	-0.6	-0.4	-0.6	-0.8
Pulse wave peak to peak time	0.7	0.8	1.6	1.1	-0.4	0.6	1.2	0.4	1.3
Migraine (self-reported)	0.7	0.9	2.4	0.7	1.6	0.5	0.3	0.9	1.1
Number of full sisters	0.7	0.8	1.9	0.7	1.4	1.2	0.6	0.5	0.7
Overall health rating	0.7	1.4	3.8	-0.8	0.9	-0.6	-1.4	-1.0	-2.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.6	1.3	-0.5	-0.5	0.6	1.2	1.2
Illnesses of father: High blood pressure	0.7	0.8	2.3	-0.3	-1.0	0.2	-0.8	-0.8	-1.5
LDL Cholesterol	0.6	0.9	1.8	-1.0	-0.9	0.0	-0.8	-1.3	-0.9
Blood Platelet Count	0.6	7.0	33.5	-0.3	5.8	-0.4	-1.5	-2.4	-0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.2	3.2	-0.8	1.1	1.0	-0.4	-1.8	-0.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.4	-0.4	0.5	-0.8	-1.0	-0.9	-1.2
Diabetes (mother)	0.6	0.8	1.5	-1.2	0.1	-0.6	-1.0	-1.1	-0.9
Supplements: Glucosamine	0.6	0.8	1.6	-0.6	-0.8	-1.3	-0.4	-1.1	-0.7
Medication: Ramipril	0.6	0.8	1.9	-1.1	0.8	-0.3	-0.6	-1.4	-0.7
Pulse wave reflection index	0.6	0.7	1.7	-1.3	-0.5	-0.4	-0.5	-0.8	-1.1
Number of children fathered	0.6	0.7	1.9	-1.1	0.2	-0.6	-1.4	-0.3	-0.5
Comparative height size at age 10	0.6	3.2	9.2	-1.9	-3.0	-1.5	-1.4	-1.2	-0.4
Supplements: Vitamin C	0.6	0.7	1.7	-0.4	0.2	-0.7	-1.0	-0.8	-1.3
Illnesses of father: Heart disease	0.6	0.8	1.4	-0.8	-1.0	0.8	-0.3	-1.2	-1.1
Medication: Atorvastatin	0.6	0.7	2.7	-0.4	-0.1	0.2	-1.0	-0.5	-1.6
Fractured/broken bones in last 5 years	0.6	0.8	4.3	0.5	2.1	0.1	0.2	-0.3	0.2
Depressed Affect (Nagel 2018)	0.5	1.1	2.6	-1.1	-1.6	-1.0	-0.3	-1.1	-0.6
Worry (Nagel 2018)	0.5	1.0	3.5	1.2	1.9	-0.4	0.4	0.7	0.2
Alzheimer’s Disease (in mother)	0.5	0.6	1.5	-0.7	-0.4	1.2	0.7	-0.8	-0.3
HbA1C	0.5	0.5	1.5	-0.7	-1.2	0.6	-0.5	-0.4	-0.6
Hand grip strength (left)	0.5	1.3	3.5	-1.6	-1.9	-0.1	-0.3	-1.2	-0.3
Relative age of first facial hair	0.5	0.9	1.5	0.7	1.2	0.6	0.6	1.2	1.2
Ever used hormone-replacement therapy (HRT)	0.5	0.6	3.0	0.2	1.7	-0.6	-0.5	-0.3	-0.1
Medication: Metformin	0.5	0.7	2.7	1.0	1.6	0.5	0.0	0.4	0.1
Pack years adult smoking proportion	0.5	0.7	1.7	-0.4	0.5	-0.8	-1.3	0.2	-1.1
Average weekly fortified wine intake	0.5	0.6	1.7	0.3	0.8	1.0	0.4	1.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.5	0.9	1.6	0.2	0.3	0.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.2	0.6	1.5	0.7	-0.6	0.5	0.0
Nervous feelings	0.5	0.8	2.0	1.1	0.8	0.1	1.4	0.4	1.0
Depression (self-reported)	0.5	0.5	2.2	-0.3	1.5	0.8	-0.5	0.0	-0.0
Medication: Lansoprazole	0.5	0.5	1.4	-0.4	1.2	0.4	-1.0	-0.3	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.6	-1.6	-1.9	-1.1	0.4	-1.0	1.0
Hair/balding pattern: Pattern 4	0.5	1.1	2.9	1.7	0.5	0.4	1.3	1.3	0.3
Birth weight of first child	0.5	0.9	3.5	0.1	-1.9	-0.0	0.5	1.2	0.6
Headache pain in last month	0.5	0.9	1.9	0.4	1.4	-0.8	-1.0	1.3	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.0	-0.0	0.8	-1.4	-1.1	0.2	-0.4
Health satisfaction	0.5	0.6	1.8	0.3	0.8	-1.3	-0.9	0.2	-0.5
Medication: Blood pressure	0.5	1.0	4.5	0.3	2.1	1.1	0.0	0.1	0.2
Pulse rate, automated reading	0.5	1.5	2.1	-1.4	-0.1	-1.4	-1.3	-1.5	-1.0
Medication: Gliclazide	0.5	0.6	1.3	-0.3	-0.2	-0.4	-0.9	-1.1	-0.9
Medication: Paracetamol	0.5	0.8	1.7	-0.4	0.3	-1.3	-1.3	1.0	-0.7
Myopia	0.5	0.7	2.5	0.5	-0.5	0.8	1.6	-0.3	0.8
Pack years of smoking	0.5	0.7	1.9	-0.1	0.4	-0.9	-1.4	0.5	-1.1
Bipolar Disorder or Schizophrenia	0.4	1.0	4.5	-0.2	0.5	0.0	-2.1	-0.0	-1.1
Alzheimer’s Disease (in father)	0.4	0.5	1.2	-0.5	0.1	1.1	-0.3	-0.7	-0.8
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.7	1.2	-0.9	0.3	1.3	0.8	1.0
Ovarian Cancer	0.4	0.6	2.5	0.2	1.6	0.1	-0.5	0.7	0.4
Primary Biliary Cirrhosis	0.4	0.6	1.1	-1.1	-0.4	-0.5	-0.9	-0.7	-0.7
Schizophrenia (2014)	0.4	0.9	2.1	0.8	1.5	0.0	-0.9	1.4	0.0
Ulcerative Colitis	0.4	0.6	1.7	0.9	-0.4	0.0	0.6	1.3	0.6
Waist Hip Ratio (WHR)	0.4	1.7	4.2	1.6	2.1	-0.4	0.0	1.7	0.7
Allergy or Eczema	0.4	1.1	3.2	1.5	0.7	0.1	-0.6	1.8	0.2
Lung FEV1/FVC ratio	0.4	2.0	5.6	-1.0	-2.4	-1.2	-0.7	-1.5	-1.1
Average weekly spirits intake	0.4	0.4	0.7	-0.6	0.8	0.6	-0.8	-0.1	-0.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.3	-0.4	1.2	0.3	-0.4	-1.0	-0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	0.4	0.7	0.4	0.5	1.0	0.6
Diabetes (father)	0.4	0.5	1.6	0.5	1.3	-0.1	0.4	-0.7	-0.6
Severe depression (siblings)	0.4	0.5	1.7	-0.4	0.1	-0.4	-1.3	-0.2	-0.8
Townsend deprivation index at recruitment	0.4	0.6	2.0	-0.6	0.7	0.3	0.2	-1.4	-0.8
Fed-up feelings	0.4	0.7	2.5	-0.2	-1.6	-1.1	0.1	-0.7	-0.2
High blood pressure (mother)	0.4	0.5	0.9	0.5	0.9	0.9	0.7	0.9	0.4
Past tobacco smoking	0.4	0.7	1.1	0.6	-0.9	-0.3	1.0	0.9	1.0
Alcohol usually taken with meals	0.4	0.7	1.5	-0.0	-1.2	-1.2	-1.0	-0.4	-0.4
Mouth/teeth dental problems	0.4	0.5	1.2	0.5	-0.2	-0.6	0.5	1.0	1.1
Pain all over the body in last month	0.4	0.4	0.7	0.1	-0.1	-0.7	-0.7	-0.8	-0.9
Diabetes (self-reported)	0.4	0.6	1.9	-0.3	0.8	0.2	-0.7	-1.4	-0.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.1	-1.3	-1.4	0.0	1.1	-1.2	1.5
Lung cancer (father)	0.4	0.5	0.8	-0.6	-0.9	-0.7	-0.9	-0.2	-0.8
Breastfed as a baby	0.4	0.5	1.5	1.2	0.8	0.3	-0.2	1.0	-0.1
Peak expiratory flow (PEF)	0.4	1.0	1.5	-1.2	-0.3	0.8	0.9	-1.2	1.1
Blood clot in the leg (DVT)	0.4	0.5	2.3	-0.1	0.1	-1.5	0.1	-0.8	-0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	2.5	-0.1	-1.6	-1.1	0.0	-0.2	0.1
Glaucoma (self-reported)	0.4	0.5	1.2	-0.2	1.1	0.3	-1.0	0.4	-0.4
Medication: Allopurinol	0.4	0.5	2.1	-0.5	0.1	1.4	0.8	-0.5	0.2
Had major operations	0.4	0.4	1.2	-1.1	-0.2	0.5	-0.3	-0.4	-0.8
Age at last live birth	0.4	0.5	1.7	0.4	-1.3	-0.1	-0.6	0.2	-1.0
Smoking status: Previous	0.4	0.7	1.7	-0.8	0.5	0.6	-0.6	-1.3	-1.0
Ever had bowel cancer screening	0.4	0.5	1.5	0.6	1.2	0.6	-0.4	0.1	0.6
Diabetes diagnosed by doctor	0.4	0.6	1.0	-0.0	0.9	0.2	-0.9	-0.9	-1.0
Asthma (self-reported)	0.4	0.8	2.6	0.2	1.6	1.2	-0.4	0.7	-0.0
Smoking status: Current	0.4	0.6	1.4	-0.6	0.5	-0.9	-1.2	-0.3	-0.9
Average weekly champagne plus white wine intake	0.4	0.6	2.0	-0.1	-0.8	-1.4	-0.7	0.4	-0.3
Wears glasses or contact lenses	0.4	0.4	1.3	0.6	0.6	0.5	-0.3	1.2	0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.7	0.3	1.0	1.3	0.4	-0.6	0.2
Medication: Lisinopril	0.4	0.5	1.2	0.0	0.8	1.1	-0.6	0.8	0.3
Diastolic blood pressure, automated reading	0.4	1.1	3.4	-1.1	-0.6	0.5	-1.0	-0.7	-1.8
Commuting to job workplace: Cycle	0.4	0.5	1.4	-1.0	-0.8	-0.1	0.1	-1.2	-0.3
Bipolar Disorder (2018)	0.3	0.5	1.8	-0.3	0.0	0.0	-1.3	-0.5	-0.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.0	1.0	-1.4	0.3	1.4	0.0	0.7
Schizophrenia (2018)	0.3	0.6	2.8	0.0	0.6	0.0	-1.7	0.3	-0.7
Crohns Disease (2017)	0.3	0.6	2.0	-0.4	-1.4	-0.8	0.6	-0.4	0.0
Hair Pigment	0.3	9.4	16.4	-4.0	-1.6	-1.4	-3.5	-3.2	-3.6
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.2	-0.9	-0.5	-0.3	-0.6	-0.3	-1.1
Medication for hormone replacement therapy	0.3	0.4	1.0	0.9	1.0	-0.6	-0.3	0.4	0.1
Hand grip strength (right)	0.3	0.9	2.7	-0.8	-1.6	0.7	0.3	-1.2	-0.0
Medication: Levothyroxine sodium	0.3	0.5	1.1	-1.0	-0.3	0.3	0.0	-0.9	-1.1
Forced vital capacity (FVC)	0.3	1.3	3.7	-0.7	-1.1	0.4	1.5	-0.3	1.9
Neuroticism score	0.3	0.6	1.1	-0.6	-0.9	-1.1	-0.3	-0.9	-0.7
Hair/balding pattern: Pattern 3	0.3	0.4	1.4	0.4	0.6	1.2	0.6	-0.0	0.4
Pulse rate	0.3	0.6	0.9	-0.8	1.0	0.1	-0.7	-0.9	-0.6
Asthma	0.3	0.7	2.5	0.2	1.6	1.0	-0.2	0.6	0.3
Medication: Cholesterol lowering	0.3	0.5	1.2	-0.3	1.1	1.1	-0.2	-0.5	-0.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-0.5	-0.2	0.8	1.0	-0.1	0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	2.5	-1.1	-1.3	-0.8	0.6	-0.3	1.6
Family relationship satisfaction	0.3	0.4	1.2	0.7	-1.1	-0.5	0.6	0.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.5	-0.3	-0.0	1.2	0.5	-0.3	-0.4
Knee pain experienced in last month	0.3	0.5	1.6	-0.3	-0.3	0.1	-0.0	-1.0	-1.3
Long-standing illness, disability or infirmity	0.3	0.4	0.9	-0.1	0.9	0.5	-0.6	-0.4	-0.9
Qualifications: nursing, teaching	0.3	0.4	1.0	0.0	1.0	-0.7	-0.2	-0.2	0.9
Medication for cholesterol	0.3	0.4	1.0	0.2	-0.4	0.5	0.6	0.8	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.1	-0.4	0.5	-0.2	-0.4	-1.1	-0.1
Medication: Bendroflumethiazide	0.3	0.5	1.1	-0.7	-1.1	0.2	-0.2	-0.5	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.5	-0.0	0.3	-1.2	0.2	-0.7	-0.4
Irritable Bowel Disease (IBD)	0.2	0.4	1.9	-0.2	-1.4	-0.5	-0.0	-0.1	-0.6
Ulcerative Colitis (UC)	0.2	0.4	1.4	0.4	-1.2	-0.0	-0.0	0.6	-0.5
Blood Eosinophil Count	0.2	1.9	4.7	0.7	2.2	1.0	-0.0	2.1	0.6
Tanning	0.2	2.2	9.0	0.5	-0.5	-3.0	-1.6	1.2	-0.2
Vitamin and mineral supplements	0.2	0.3	1.3	-0.3	-1.2	0.2	0.2	0.5	0.1
Serious illness, injury or assault to yourself	0.2	0.2	0.3	-0.5	-0.0	0.5	-0.4	-0.5	-0.4
Hayfever, allergic rhinitis or eczema	0.2	0.5	0.8	0.8	0.5	0.5	-0.8	0.9	-0.5
Qualifications: None of the above	0.2	0.4	0.9	-0.3	0.4	-0.9	-0.8	-0.5	-0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	0.4	0.1	-0.6	-0.9	0.3	-0.6
Fluid intelligence score	0.2	0.5	0.8	0.7	-0.7	-0.1	0.9	0.6	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.2	-0.8	0.6	0.9	-0.5	-0.3
Medication: Amlodipine	0.2	0.3	0.7	-0.4	-0.1	-0.7	-0.4	-0.7	-0.8
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.5	-0.7	0.5	0.2	-0.7	-0.0	-0.4
Eye problems/disorders: None of the above	0.2	0.3	0.6	0.3	0.8	-0.3	0.7	-0.4	0.3
Emphysema/chronic bronchitis	0.2	0.2	0.9	0.1	-0.2	0.4	0.3	-0.9	-0.2
Medication: Seretide 50 evohaler	0.2	0.2	0.8	0.2	0.9	0.3	-0.2	0.4	-0.5
Alcohol intake frequency.	0.2	0.5	1.6	-0.2	0.6	1.3	0.5	-0.8	0.5
Mood swings	0.2	0.4	0.9	-0.7	-0.5	-0.9	-0.6	-0.8	-0.1
Eye problems/disorders: Cataract	0.2	0.2	0.8	-0.1	-0.9	0.3	0.6	-0.2	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	-0.1	0.8	0.8	-0.1	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.1	-1.1	-0.2	0.5	0.7	0.1	0.8
Age started oral contraceptive pill	0.2	0.2	0.7	-0.5	-0.9	0.1	-0.1	-0.5	-0.4
Depression (Nagel 2018)	0.1	0.2	0.5	-0.6	0.1	-0.0	-0.3	-0.2	-0.7
Blood White Count	0.1	0.8	2.4	-1.2	0.2	0.0	-0.6	-0.6	-1.6
Systolic Blood Pressure	0.1	0.3	0.9	0.3	0.2	-0.1	-0.8	-0.0	-1.0
Hypothyroidism (self reported)	0.1	0.2	0.6	0.4	-0.0	0.4	0.8	0.3	0.2
Respiratory disease	0.1	0.3	0.5	0.1	0.7	0.3	-0.7	0.7	-0.3
Sensitivity / hurt feelings	0.1	0.2	0.9	-0.1	0.4	-0.2	-0.5	1.0	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	0.2	0.5	0.4	0.2	-0.1	-0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.2	-0.3	0.4	0.4	0.1	-0.2	-0.3
Hearing difficulty/problems with background noise	0.1	0.1	0.4	0.2	-0.2	0.1	0.6	-0.6	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.1	0.1	0.1	-0.2	0.5	0.4
Allergy	0.1	0.3	0.9	-0.0	-0.5	0.0	1.0	0.0	0.8
Worrier / anxious feelings	0.1	0.2	0.6	0.5	0.2	-0.4	0.8	0.2	0.5
Happiness	0.1	0.1	0.2	0.3	-0.1	-0.2	0.5	0.3	-0.3
Illnesses of mother	0.1	0.1	0.3	0.1	-0.5	-0.6	-0.1	-0.3	0.0
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.1	0.0	-0.6	0.1	0.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	-0.0	0.7	-0.5	-0.4	0.2	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.0	0.4	-0.5	-0.6	0.1	-0.0
Qualifications: College or University degree	0.1	0.3	0.5	0.2	-0.7	-0.1	0.2	0.6	0.7
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	0.4	0.5	-0.0	0.1	-0.1	-0.0
Heart disease (mother)	0.1	0.1	0.2	-0.3	0.5	0.1	-0.2	-0.1	0.1
Suffer from ‘nerves’	0.1	0.1	0.2	-0.0	0.3	-0.5	0.5	-0.2	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.1	-0.5	0.3	0.5	-0.4	0.3
Friendships satisfaction	0.1	0.1	0.2	0.3	0.5	0.2	-0.1	0.0	-0.4
Mineral and other dietary supplements	0.1	0.1	0.3	-0.4	-0.5	0.1	0.0	0.1	0.0
Ever smoked	0.1	0.2	0.5	-0.4	0.3	0.1	-0.7	-0.3	-0.4
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.2	0.1	-0.2	0.5	-0.0	0.2
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.2	0.2	-0.1	0.0	0.4	-0.1	0.4
Type 2 Diabetes (T2D) (2012)	0.0	0.1	0.1	0.3	0.0	0.4	0.3	0.0	0.2
Relative age voice broke	0.0	0.1	0.1	-0.3	0.2	-0.3	-0.3	-0.2	0.1
Guilty feelings	0.0	0.1	0.1	0.2	0.3	-0.1	0.2	-0.1	-0.3
Alcohol drinker status: Never	0.0	0.1	0.2	-0.4	0.1	-0.1	-0.1	-0.3	0.1

Hub : Genes

LOC100134368

Models

Trait associations