Hub : Genes

ARHGDIG

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.3010 0.0620 4.4e-07 -0.002 NA 0.037 NA 0.047 4.4e-01 NA 3.9e-03 NA 1.4e-03
2 GTEx Esophagus Muscularis 0.1550 0.0570 3.0e-03 -0.001 NA 0.019 NA 0.012 3.8e-01 NA 2.5e-02 NA 5.5e-02
3 GTEx Heart Atrial Appendage 0.2260 0.0670 1.2e-04 0.042 NA 0.088 NA 0.086 5.8e-03 NA 8.9e-05 NA 1.1e-04
4 GTEx Heart Left Ventricle 0.2294 0.0580 7.3e-06 0.164 NA 0.128 NA 0.147 4.7e-09 NA 2.5e-07 NA 3.1e-08
5 GTEx Muscle Skeletal 0.1978 0.0621 4.1e-04 0.009 NA 0.017 NA 0.015 3.6e-02 NA 7.0e-03 NA 1.1e-02
6 GTEx Nerve Tibial 0.1333 0.0568 5.4e-03 0.074 NA 0.025 NA 0.072 6.1e-06 NA 6.1e-03 NA 8.0e-06
7 GTEx Small Intestine Terminal Ileum 0.6200 0.1180 2.6e-04 -0.004 NA 0.065 NA 0.079 4.0e-01 NA 1.5e-02 NA 7.9e-03
8 GTEx Stomach 0.1210 0.0500 8.6e-03 0.028 NA 0.055 NA 0.037 1.7e-02 NA 1.2e-03 NA 6.7e-03
9 TCGA Prostate Adenocarcinoma 0.0766 0.0323 5.4e-05 0.004 0.041 0.042 NA 0.029 1.2e-01 4.1e-05 3.3e-05 NA 4.6e-04
10 TCGA Thyroid Carcinoma 0.0920 0.0510 3.6e-03 0.007 0.032 0.011 NA 0.010 6.7e-02 3.7e-04 2.4e-02 NA 3.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.6 1.0 3.1 0.4 0.1 -1.2 -1.8 1.6 0.0 0.5 0.2 1.3 0.6
Bipolar Disorder or Schizophrenia 0.3 0.7 1.8 0.6 0.8 -1.3 -1.3 0.6 0.0 0.6 -0.4 -0.2 1.1
Depressed Affect (Nagel 2018) 0.3 0.6 2.0 -0.9 -1.4 -0.8 -0.8 0.4 1.2 0.3 0.7 0.1 0.3
Depression (Nagel 2018) 0.8 1.3 3.9 -2.0 -0.8 0.7 0.4 -0.5 0.7 0.8 1.3 -0.7 1.9
Intelligence (Savage-Jansen 2018) 0.9 2.9 7.5 2.1 2.7 0.3 0.8 0.2 -2.3 0.1 -1.6 0.8 -2.7
Neuroticism (Nagel 2018) 0.4 0.9 5.5 -2.4 -0.9 -0.5 -0.0 -1.1 0.4 0.3 0.1 -1.0 0.5
Schizophrenia (2018) 0.3 0.6 2.1 0.4 0.9 -0.7 -0.3 -0.5 0.0 0.4 -0.8 -1.4 1.0
Schizophrenia vs Biploar Disorder 0.2 0.2 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.4 0.1
Worry (Nagel 2018) 1.5 3.2 13.1 -3.6 -0.7 0.4 1.1 -1.7 0.2 -0.1 0.3 -2.8 2.5
Alzheimer’s Disease (in mother) 0.4 0.4 1.0 0.7 1.0 0.8 0.7 0.3 0.5 -0.0 0.7 0.9 -0.0
Alzheimer’s Disease (in father) 1.3 1.4 4.4 -1.8 0.6 1.1 1.1 -1.2 1.3 0.7 2.1 -0.0 0.4
Alzheimer’s Disease (including proxy) 0.7 1.1 4.1 0.3 1.2 1.9 2.0 -0.3 0.3 -0.3 0.9 0.5 -0.6
Crohns Disease (2017) 0.1 0.2 0.7 0.3 0.0 -0.1 0.5 -0.8 0.3 -0.7 0.7 0.4 -0.5
Irritable Bowel Disease (IBD) 0.2 0.4 1.1 1.1 0.6 0.1 0.5 0.6 0.1 0.9 -0.6 0.5 0.4
Ulcerative Colitis (UC) 0.7 1.3 3.6 1.1 1.2 -0.2 0.1 1.9 -0.5 1.7 -1.6 0.4 0.7
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.5 1.0 4.7 0.4 -0.2 -0.5 -0.6 0.2 1.5 -0.4 2.2 1.1 -0.8
Verbal and Numeric Reasoning (VNR) 0.8 1.9 8.3 0.9 2.9 -0.3 0.2 1.2 -1.5 0.5 -1.1 0.9 -1.8
Breast Cancer 0.3 0.8 3.0 -0.4 0.8 -0.3 0.1 -1.2 -0.9 1.7 0.9 -0.4 0.6
Ovarian Cancer 0.1 0.1 0.3 0.6 -0.4 -0.3 -0.1 -0.4 -0.3 0.2 -0.5 -0.5 -0.1
Prostate Cancer 2.3 3.3 9.4 1.0 -0.2 -3.1 -2.9 0.8 -2.4 0.2 -2.3 -0.3 -1.6
Age at First Birth 1.7 2.4 4.5 1.3 2.1 -1.8 -2.1 1.5 0.6 -0.9 -1.3 1.2 -1.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.4 2.0 7.6 0.7 -0.7 1.4 1.5 1.5 0.0 -0.1 2.8 0.8 2.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.2 0.3 1.8 -0.1 0.0 -0.1 0.1 0.0 0.0 -1.3 1.2 -0.1 -0.1
Mean Putamen Volume 0.8 0.9 4.0 -1.0 -0.4 -0.5 -0.9 -0.8 0.0 -0.8 -0.7 -2.0 0.8
Fasting Glucose 0.6 0.7 1.3 0.6 -0.2 0.7 1.0 -0.2 -1.2 -0.9 0.9 -1.1 -0.5
HbA1C 0.8 0.9 2.0 -0.0 -0.8 1.4 1.1 0.9 0.2 -1.1 1.3 -0.4 -1.1
HDL Cholesterol 1.5 2.4 4.8 -2.2 -1.8 -1.9 -1.7 -1.0 0.0 -0.0 -2.1 -2.0 -0.7
LDL Cholesterol 0.9 1.4 3.1 -0.7 -1.7 1.7 1.8 1.2 0.0 0.5 0.7 0.3 1.5
Lupus 0.8 1.2 3.0 -1.0 -1.4 -1.6 -1.7 -0.8 -0.5 -1.0 0.2 -0.5 -1.1
Neuroticism (2016) 0.9 1.4 3.3 -1.7 -1.0 -1.2 -1.8 -0.5 1.8 0.4 0.8 0.6 0.7
Primary Biliary Cirrhosis 0.3 0.4 1.3 -0.5 -0.7 0.4 0.6 0.1 0.0 0.1 0.8 -1.1 0.9
Rheumatoid Arthritis 0.6 0.8 4.4 -0.2 -1.1 0.2 0.1 -0.4 0.0 -0.8 2.1 0.9 -0.6
Schizophrenia (2014) 0.5 1.0 4.1 0.6 -0.1 -0.4 -0.0 0.2 0.0 0.9 -1.6 -2.0 1.5
Triglycerides 1.0 1.6 5.3 0.2 0.9 2.3 2.1 0.9 0.0 -0.8 1.3 1.4 0.3
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 -0.2
Ulcerative Colitis 0.5 0.7 4.1 0.6 0.5 0.4 0.6 0.0 0.0 1.1 -2.0 0.4 0.5
Blood Eosinophil Count 0.1 0.9 3.9 -0.5 -0.2 0.2 0.2 0.9 -1.0 -0.4 -1.6 -2.0 0.8
Blood Platelet Count 0.4 5.1 18.1 -0.9 -1.7 4.2 3.3 0.0 0.7 -2.7 2.2 -2.3 -0.2
Blood Red Count 1.5 15.0 34.0 0.7 -5.6 5.8 4.5 -1.4 4.5 -5.1 3.9 -0.7 -0.0
Blood White Count 0.2 1.5 8.8 -1.4 -0.6 0.5 0.7 0.3 0.5 0.3 1.4 -0.8 3.0
Heel T-Score 1.2 9.9 39.2 6.3 2.5 -0.3 1.1 0.2 -0.8 2.0 1.8 4.1 -5.2
BMI 1.9 11.2 43.0 1.3 -1.6 0.3 -0.3 1.6 6.6 1.9 4.2 3.5 5.3
Height 0.8 15.9 59.0 7.7 3.7 -1.2 -0.9 3.1 3.6 -1.0 -0.5 5.2 -5.7
Waist Hip Ratio (WHR) 0.8 3.5 11.2 -2.8 -1.7 0.1 -0.1 -1.9 -0.0 -1.5 1.7 -3.3 2.1
Systolic Blood Pressure 0.6 2.9 9.2 -1.7 -1.2 -0.4 0.2 -0.5 2.3 0.9 2.9 0.7 3.0
Smoking Status 0.6 1.4 4.0 -1.3 -1.6 0.9 0.7 -2.0 1.4 0.9 0.6 0.2 1.4
Allergy or Eczema 0.3 0.9 2.9 -0.6 -0.6 -0.3 -0.5 -0.8 -1.1 -0.2 -1.7 -1.7 0.5
Cardiovascular Disease 2.3 7.8 24.4 -2.2 -0.7 2.4 3.1 -0.3 3.1 0.5 4.4 -1.7 4.9
Hypothyroidism (self reported) 0.6 1.4 5.5 -1.7 -1.0 0.6 1.1 -0.2 -1.5 -0.1 0.5 -2.3 0.7
Respiratory disease 0.5 1.1 5.9 -2.4 -0.1 -0.3 -0.5 -0.1 -0.4 -0.5 1.2 -1.6 0.8
Type 2 Diabetes (T2D) (2018) 3.1 5.9 16.0 -3.8 -2.0 1.5 1.3 -1.2 2.7 -2.1 4.0 -1.9 1.9
Lung FEV1/FVC ratio 0.1 0.4 2.0 -0.4 -0.2 -0.5 -0.4 0.2 1.4 -0.8 0.7 0.0 0.4
Lung FVC 0.4 2.0 8.0 -1.5 -0.3 -1.5 -0.8 -2.8 -1.3 -0.0 -1.2 0.1 -1.9
Neuroticism 0.9 2.1 8.2 -2.9 -0.9 -0.8 -0.1 -1.0 1.6 0.8 1.6 -0.3 2.1
Chronotype (morning person) 0.6 1.3 2.9 1.2 0.1 0.8 1.3 0.7 -1.3 1.6 -1.1 -0.2 1.7
Hair Pigment 0.1 2.4 8.0 -0.2 -0.4 1.8 1.5 -0.3 2.8 -0.3 2.4 0.4 2.1
Tanning 0.2 2.6 7.8 2.1 0.2 -2.5 -2.8 1.9 -0.1 0.6 -1.7 0.7 -0.6
Hand grip strength (left) 0.8 2.2 10.2 3.2 1.5 0.4 0.7 1.0 0.4 -0.7 -0.0 1.5 -2.2
Number of treatments/medications taken 1.7 3.0 9.1 -2.0 -1.5 0.1 0.1 -0.6 2.1 0.1 2.6 -1.7 3.0
Average weekly spirits intake 0.7 0.9 3.9 -1.4 -0.5 0.4 1.0 -0.2 1.1 -0.5 0.6 0.5 2.0
Sensitivity / hurt feelings 0.8 1.4 5.1 0.0 2.3 0.8 1.3 1.2 -1.1 0.9 -1.8 0.1 0.3
Frequency of depressed mood in last 2 weeks 1.1 1.5 5.8 -0.5 1.1 1.4 1.4 -1.0 -0.0 1.6 0.4 -0.1 2.4
Hearing difficulty/problems: Yes 0.9 1.3 4.7 0.5 0.0 -0.2 -0.6 1.2 1.9 0.3 1.7 2.2 0.4
Relative age of first facial hair 0.8 1.7 5.8 -0.7 -0.6 -2.4 -2.4 -0.3 -0.4 -1.3 -0.4 -0.1 -1.5
Other serious medical condition/disability diagnosed by doctor 1.9 2.4 7.5 -2.7 -2.6 -0.5 -0.6 -0.0 2.2 0.8 1.6 0.5 1.1
Ever used hormone-replacement therapy (HRT) 1.0 1.3 3.8 -2.0 -1.4 -1.1 -1.6 -0.1 1.3 0.1 0.9 0.6 0.6
Ever had hysterectomy (womb removed) 0.9 1.0 2.9 -0.8 -1.7 1.2 1.3 -0.1 -0.5 1.1 0.7 -0.8 0.9
Systolic blood pressure, automated reading 1.3 3.9 11.3 -2.0 -2.5 -0.7 -0.4 -0.7 2.6 1.3 3.4 0.7 2.7
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 3.7 -0.6 -1.4 -1.9 -1.5 -1.4 0.3 -0.0 0.4 -0.6 -0.3
Angina 0.4 0.5 1.7 -0.4 0.1 -1.3 -1.1 -0.1 0.6 0.8 0.4 0.8 0.5
Medication for hormone replacement therapy 0.4 0.4 1.2 -0.1 0.5 -0.9 -0.9 1.1 0.6 -0.5 0.4 0.3 0.4
Vitamin and mineral supplements 0.8 1.1 3.7 0.8 0.8 0.9 0.5 0.9 -1.0 -1.1 -1.9 -0.0 -1.4
Supplements: Zinc 1.0 1.1 2.5 -1.3 -1.6 0.8 1.2 -0.3 -1.1 1.0 0.5 -1.3 1.0
Medication: Co-codamol 1.7 2.0 9.7 -1.2 -3.1 0.5 0.4 -0.2 1.4 -0.8 1.9 -0.8 1.1
Medication: Metformin 2.8 4.0 14.4 -3.8 -2.6 0.6 0.8 -1.4 1.1 -1.7 1.9 -2.5 1.3
Diabetes (father) 5.6 7.0 16.8 -3.3 -4.1 0.8 1.1 -3.8 1.8 -2.0 2.8 -3.2 0.7
Diabetes (mother) 1.2 1.5 6.5 -2.6 -1.3 -0.1 -0.0 -1.2 -0.3 0.1 1.1 -1.7 1.1
Severe depression (siblings) 0.4 0.5 1.9 0.4 0.5 0.6 1.2 -0.1 -0.5 1.4 0.0 -0.3 -0.6
Pack years adult smoking proportion 1.1 1.6 8.5 -1.2 -2.9 0.1 0.3 -0.1 1.0 0.5 0.4 -1.1 1.8
Impedance of leg (right) 1.1 5.5 13.5 -2.7 1.3 1.0 1.0 -1.8 -3.6 -2.9 -1.0 -3.7 -2.3
Leg fat-free mass (left) 1.8 9.7 31.6 5.2 -0.1 -0.7 -0.7 2.3 5.6 1.6 2.0 5.0 0.8
Trunk fat percentage 1.8 7.2 29.8 0.3 -0.7 0.3 0.5 -0.2 5.5 1.1 4.0 1.9 4.5
Hand grip strength (right) 1.2 3.2 9.6 3.1 0.9 2.0 2.3 0.3 -1.4 -0.9 -0.5 0.2 -3.0
Townsend deprivation index at recruitment 2.4 3.4 6.8 -2.3 -2.1 1.6 1.2 -2.6 2.0 -0.5 2.5 -0.8 1.7
Current tobacco smoking 1.6 2.6 9.3 -2.2 -3.0 0.9 1.1 -0.5 0.9 0.4 1.5 -2.1 1.4
Average weekly fortified wine intake 0.6 0.7 2.2 -1.1 -1.5 -0.7 -0.2 -0.6 -1.2 -0.6 -0.6 -0.9 -0.3
Maternal smoking around birth 1.3 1.9 10.2 0.2 -0.2 0.0 -0.3 -1.0 3.2 0.0 1.9 0.4 2.0
Fed-up feelings 0.4 0.7 2.5 0.2 -0.6 -0.3 -0.9 -0.5 1.6 0.5 1.0 0.3 1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 6.5 -2.5 -0.5 0.6 0.3 -1.9 0.9 0.1 1.5 -0.6 1.5
Relative age voice broke 0.5 0.7 1.7 -0.4 -0.9 -1.3 -1.3 0.6 -0.6 -0.1 -0.7 -0.7 -1.2
Taking other prescription medications 0.7 1.2 5.7 -0.2 -0.1 0.1 -0.2 1.5 1.7 0.6 0.2 -0.5 2.4
Age when periods started (menarche) 1.9 4.4 11.3 -1.6 -0.6 2.9 3.3 -1.4 -3.4 -0.5 -1.0 -2.9 0.2
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 -0.0 -0.1 0.0 -0.2 0.5 0.3 0.7 -0.5 0.5 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.7 3.7 13.2 2.0 -0.2 0.2 0.8 -0.9 1.7 2.6 3.6 2.9 -0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 1.6 -0.3 0.3 0.2 0.2 -0.1 1.3 0.5 -0.1 0.8 0.6
Qualifications: CSEs or equivalent 1.6 2.1 6.8 -2.6 -1.3 0.4 0.5 -2.2 1.0 -0.0 1.6 -1.1 1.4
Serious illness, injury or assault to yourself 3.0 3.6 10.1 -2.1 -2.3 -1.4 -1.3 -1.0 2.6 -0.1 3.2 -0.8 2.0
High blood pressure 2.4 6.8 16.6 -1.9 -1.1 3.4 3.9 -0.6 2.3 0.5 3.4 -1.2 4.1
Hayfever, allergic rhinitis or eczema 0.7 1.5 6.2 -1.3 -1.0 0.7 0.5 -1.4 -0.5 -1.0 -0.0 -2.5 1.3
Multivitamins +/- minerals 0.7 0.9 2.8 -0.7 -0.4 -1.0 -0.4 -0.0 1.4 -0.3 1.7 -0.5 1.3
Stomach or abdominal pain in last month 2.8 3.4 7.4 -2.1 -2.7 -0.7 -1.5 0.8 2.3 -1.7 2.7 -1.2 1.7
Supplements: Glucosamine 0.8 1.0 3.5 -0.4 -0.8 -0.4 -0.5 -0.8 1.5 -1.1 1.9 0.8 -0.8
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.3 0.5 1.1 0.1 -0.3 0.5 -0.2 -0.8 -0.7 -0.4 -0.6
Medication: Atenolol 1.1 1.3 5.3 -1.7 -0.1 0.1 -0.1 -1.2 0.9 -0.5 1.5 -0.5 2.3
Medication: Levothyroxine sodium 0.7 1.2 3.5 -1.9 -1.1 0.3 0.7 -0.9 -1.0 0.7 0.7 -1.7 0.8
Sitting height 1.4 9.9 33.1 5.4 1.2 -2.2 -1.7 2.8 0.9 -0.9 -1.6 3.9 -5.8
Chronic bronchitis/emphysema (father) 1.0 1.2 3.8 -0.3 -1.7 -1.3 -1.9 -0.1 1.4 -1.3 0.2 0.2 0.2
High blood pressure (mother) 2.0 2.8 6.0 -2.3 -0.6 1.9 2.3 -1.9 -0.6 -0.4 0.6 -2.5 1.6
Body mass index (BMI) 2.2 9.3 36.7 0.8 -2.0 0.6 0.4 -0.4 6.1 1.5 4.3 2.6 4.9
Impedance of leg (left) 1.1 5.4 12.8 -2.7 1.6 1.0 1.2 -1.8 -3.5 -2.7 -1.2 -3.6 -1.9
Leg predicted mass (left) 1.8 9.8 32.0 5.2 -0.3 -0.9 -0.9 2.2 5.7 1.6 1.9 5.1 0.7
Trunk fat mass 1.8 7.7 35.5 2.2 -0.3 0.3 0.3 0.7 6.0 1.0 3.7 2.9 3.5
Waist circumference 1.9 7.0 27.2 1.0 -1.8 1.0 0.9 0.2 5.2 0.5 4.3 1.4 4.0
Number of incorrect matches in round 1.0 1.7 6.9 0.5 0.4 -1.8 -2.6 1.9 1.5 0.0 -0.5 -0.3 0.8
Past tobacco smoking 0.7 1.2 3.7 -0.8 -1.9 -0.3 -0.1 1.9 -0.0 -1.1 0.7 -1.6 -0.1
Alcohol usually taken with meals 1.0 1.6 3.7 1.3 1.9 0.7 0.1 1.9 -0.3 -1.5 0.5 -1.5 -1.4
Nervous feelings 0.6 1.1 5.4 -2.3 0.7 -0.7 -0.0 -0.7 -0.0 0.4 0.3 -0.8 1.7
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.4 6.8 -2.5 -0.1 1.1 0.6 -2.1 0.5 1.7 -0.1 -1.2 2.6
Hearing difficulty/problems with background noise 0.5 0.8 1.7 -0.9 0.5 0.0 -0.3 1.3 0.9 -1.0 1.3 1.3 0.3
Hair/balding pattern: Pattern 2 0.5 0.6 2.3 -0.5 1.0 -0.2 -0.2 1.1 0.9 -0.1 -0.2 1.5 -0.4
Had menopause 0.7 0.8 1.9 -0.2 0.1 -0.7 -1.1 0.5 1.1 1.4 1.2 1.2 -0.6
Had other major operations 0.5 0.6 3.2 -0.3 -1.2 -0.6 -0.5 0.4 0.2 1.8 0.8 -0.4 -0.0
Forced vital capacity (FVC) 0.6 2.2 8.5 1.4 1.4 -1.4 -1.2 -0.8 0.5 -1.5 -0.9 1.5 -2.9
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.6 9.4 2.1 -0.4 -0.3 0.1 -1.0 0.6 2.3 3.1 2.3 -0.8
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 3.6 -1.9 -0.1 -0.8 -0.6 1.3 1.0 0.4 -0.4 0.6 1.4
Qualifications: None of the above 0.9 1.9 8.1 -2.2 -2.8 0.3 -0.3 -1.1 0.9 -1.0 1.4 -0.3 1.2
Financial difficulties in last 2 years 1.3 1.8 5.8 -0.4 -0.9 0.7 0.5 0.9 2.4 0.8 1.6 1.0 2.3
Mouth/teeth dental problems 0.8 1.2 3.3 1.3 1.4 -1.4 -0.9 0.3 -1.8 -0.2 -1.5 -0.6 -0.3
Heart attack 0.5 0.6 1.6 -0.1 -0.0 0.2 -0.3 1.3 1.1 1.1 0.9 0.3 1.0
Allergy 0.4 0.9 2.7 1.3 0.8 -0.8 -0.5 0.9 0.2 0.4 -0.4 1.6 -1.4
Pain all over the body in last month 0.8 0.8 3.0 -0.3 1.7 1.1 1.0 -0.6 1.2 -0.7 0.8 -0.2 0.2
Diabetes (self-reported) 2.2 3.4 12.4 -3.5 -1.7 0.8 0.8 -0.9 1.4 -1.0 2.8 -1.9 1.5
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.1 -1.0 0.0 -0.4 -0.6 -0.8 -0.5 0.7 -0.4 -0.4 0.7
Medication: Ramipril 0.5 0.6 2.9 0.3 0.6 0.1 0.7 0.2 -0.3 1.7 0.5 -0.8 1.1
Medication: Simvastatin 1.8 2.7 9.5 -0.9 0.5 0.1 0.1 0.1 3.1 0.6 3.0 1.1 2.3
Fluid intelligence score 0.9 1.9 7.6 1.3 2.8 -1.6 -1.0 0.7 -1.1 1.2 -1.4 0.9 -1.0
Illnesses of siblings 4.0 5.6 12.1 3.2 2.1 0.0 -0.1 3.2 -2.3 -0.2 -3.3 1.6 -3.5
Neuroticism score 0.4 0.9 3.0 -1.4 0.8 -0.1 0.5 -0.0 0.9 1.5 0.5 0.0 1.7
Weight 1.9 9.3 41.6 3.9 -0.6 -0.1 -0.2 1.2 6.5 0.9 3.3 4.4 1.9
Impedance of arm (right) 0.6 3.0 9.7 -2.4 1.7 -0.2 -0.0 -0.4 -3.1 -1.2 -1.4 -2.3 -1.6
Arm fat percentage (right) 2.0 7.9 29.5 -0.1 -1.1 0.5 0.4 -0.6 5.4 1.5 4.1 1.7 5.1
Trunk fat-free mass 1.6 9.1 39.3 6.3 0.4 -0.4 -0.7 2.9 4.1 0.3 0.4 4.6 -2.0
Hip circumference 1.8 7.9 33.6 3.1 -1.3 0.1 -0.1 1.0 5.8 0.8 3.4 3.8 2.5
Time employed in main current job 1.7 1.9 8.9 -1.3 -1.1 -0.8 -0.7 0.9 1.2 1.5 0.0 -1.3 3.0
Alcohol intake versus 10 years previously 0.5 0.8 2.1 -1.5 -0.5 -1.3 -1.0 -1.5 -0.3 0.1 -0.9 -0.2 -0.2
Father’s age at death 1.3 1.8 5.2 1.1 1.5 0.4 0.2 2.3 -1.4 -0.2 -2.0 -0.2 -1.7
Worrier / anxious feelings 0.5 1.0 3.7 -1.9 0.6 0.6 1.1 -1.1 -0.3 -0.9 0.6 -1.4 -0.1
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.6 7.1 -1.9 -0.4 2.0 2.0 -0.6 0.7 1.0 1.8 -1.3 2.7
Falls in the last year 1.4 1.9 7.2 0.5 -0.5 -1.5 -2.2 0.7 2.7 0.8 0.7 0.7 1.4
Hair/balding pattern: Pattern 3 0.5 0.8 2.3 0.8 1.1 1.0 1.3 0.9 -1.5 0.0 0.2 0.1 -0.6
Number of live births 0.8 1.2 3.7 -0.3 -0.8 1.5 1.0 -0.2 1.1 0.9 1.9 -0.3 1.4
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 3.7 0.6 1.6 -1.5 -1.2 -1.0 1.3 -1.4 0.3 1.3 -1.9
Pulse rate 0.7 1.1 4.2 -0.7 -1.6 0.3 0.3 -0.3 0.6 1.8 0.4 0.1 2.0
Happiness 0.5 0.7 2.8 -0.8 0.8 -1.0 -0.8 0.6 0.4 -1.7 -0.3 -0.2 -0.6
Noisy workplace 1.0 1.3 4.3 -0.7 -1.3 -0.1 0.1 -0.8 1.9 0.5 1.5 0.3 2.1
Qualifications: A levels/AS levels or equivalent 0.9 1.9 8.1 -0.0 2.8 -0.8 -0.4 0.6 -2.0 0.4 -1.7 0.4 -1.7
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.8 7.0 -1.3 -0.7 0.8 1.4 -2.0 -1.2 0.1 0.8 -2.6 0.1
Mouth/teeth dental problems: Dentures 0.6 1.0 2.7 -0.5 -1.5 0.0 0.1 1.5 1.6 -0.2 1.4 0.4 0.8
Asthma 0.3 0.6 2.9 -1.7 -0.2 -0.3 -0.4 -0.6 -0.7 0.2 0.5 -1.1 0.7
Medication: Ibuprofen (e.g. Nurofen) 2.2 2.8 8.0 1.3 0.6 1.3 1.1 -0.5 2.4 1.7 1.9 1.5 2.8
Medication: Cholesterol lowering 0.9 1.4 5.0 -1.3 0.1 0.4 0.9 -0.3 1.6 -0.1 2.2 -0.6 1.9
Depression (self-reported) 0.7 0.9 2.5 -0.4 0.8 0.6 1.3 1.0 -0.4 1.4 -0.2 -0.5 1.6
Medication: Lansoprazole 0.8 0.9 2.5 -1.6 -0.5 -1.2 -1.1 0.3 0.9 0.2 0.9 0.2 1.5
Prospective memory result 1.5 1.8 6.3 -0.1 0.8 1.2 1.4 -1.1 -2.5 -0.7 -1.8 -1.6 -0.2
Lung cancer (father) 0.1 0.1 1.2 -0.1 0.0 -0.1 -0.2 -1.1 0.3 0.1 -0.1 -0.2 -0.2
Illnesses of mother 0.9 1.1 4.5 1.0 0.7 -0.6 -1.2 0.5 1.2 -0.6 -0.3 2.1 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.7 5.3 1.0 0.8 -2.0 -1.9 -0.7 2.1 -1.8 0.3 2.0 -2.3
Pulse wave Arterial Stiffness index 0.7 0.8 2.2 -1.5 -0.8 1.1 1.1 1.2 0.0 0.4 -0.4 -0.5 0.6
Impedance of arm (left) 0.6 2.7 8.0 -2.8 1.2 -0.2 -0.0 -0.7 -2.6 -1.1 -1.2 -2.4 -1.2
Arm fat mass (right) 1.9 7.9 34.9 1.7 -1.1 0.5 0.3 0.3 5.9 1.4 3.9 2.6 4.0
Trunk predicted mass 1.6 9.1 39.3 6.3 0.4 -0.3 -0.7 2.9 4.1 0.3 0.5 4.6 -1.9
Standing height 1.5 14.6 52.1 7.2 2.9 -1.6 -1.6 3.9 1.6 -1.0 -2.0 4.5 -6.1
Length of working week for main job 1.8 2.0 4.9 1.2 1.3 1.5 0.5 2.2 2.1 0.8 1.0 1.0 1.5
Exposure to tobacco smoke at home 0.7 0.7 2.2 -0.9 -1.5 -1.0 -0.7 -0.6 0.2 0.5 0.5 -0.3 1.4
Breastfed as a baby 1.2 1.5 4.2 -0.1 -0.4 1.5 1.1 -1.2 -1.7 -1.1 0.9 -2.0 -1.0
Tense / ‘highly strung’ 0.6 1.0 3.6 -1.9 -0.1 -0.5 0.1 -0.6 0.6 -0.0 -0.6 -1.2 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.5 -1.1 1.2 -0.1 0.4 0.5 -0.2 1.6 -1.2 -0.7 1.9
Hair/balding pattern: Pattern 4 1.0 2.5 6.2 -1.2 -0.4 2.1 2.3 -0.3 -1.6 0.2 -0.9 -2.5 2.1
Birth weight of first child 1.0 1.9 7.4 1.8 -0.7 -0.6 0.1 0.7 -2.0 -0.2 -1.7 0.3 -2.7
Peak expiratory flow (PEF) 0.7 1.5 4.0 0.6 1.6 -1.5 -1.0 0.0 1.6 -2.0 1.1 0.8 -0.7
Pulse wave reflection index 0.4 0.5 2.1 -0.5 -0.1 1.2 1.0 1.5 -0.3 -0.1 -0.0 -0.5 -0.5
Ever highly irritable/argumentative for 2 days 1.5 1.8 8.2 -2.5 -1.1 -0.6 -0.4 0.1 0.6 -0.2 0.8 -0.5 2.9
Loud music exposure frequency 0.6 0.7 2.3 -0.9 0.0 0.6 1.2 -1.5 -0.3 -0.4 0.3 1.2 -0.5
Qualifications: O levels/GCSEs or equivalent 1.4 2.3 8.6 2.2 1.4 -0.8 -0.4 0.3 -2.9 1.0 -2.3 -0.1 -0.7
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.8 0.9 0.1 0.1 -0.3 -1.5 0.8 -0.9 0.0 1.7 -1.5
Blood clot in the leg (DVT) 0.6 0.7 2.5 -0.3 0.4 1.6 1.4 -0.3 0.3 1.1 -0.4 -0.3 0.9
Medication: Paracetamol 1.3 2.1 10.2 -1.4 -0.6 -1.3 -1.5 -0.0 1.4 0.9 0.7 -1.2 3.2
Headache pain in last month 0.6 1.0 2.9 -1.3 -1.1 -1.0 -0.9 -1.2 0.4 -0.2 -0.5 -1.7 0.9
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.5 0.7 -0.5 -0.6 -1.0 0.6 -1.1 -0.1 -1.3 -0.1 -1.6
Glaucoma (self-reported) 0.5 0.5 2.5 -0.6 -0.3 0.2 0.2 0.9 -0.4 0.7 -1.6 -1.0 -0.2
Gout (self-reported) 1.3 1.7 8.1 0.9 2.5 0.2 0.4 -0.0 0.2 1.0 -0.2 2.9 -0.7
Hypothyroidism/myxoedema (self-reported) 0.6 1.1 5.4 -1.2 -0.8 0.5 1.0 -0.3 -1.3 0.3 0.3 -2.3 0.4
Medication: Amlodipine 0.7 1.0 2.6 -0.4 0.2 1.4 1.6 1.4 0.4 -0.8 1.1 -0.4 1.1
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.5 -0.3 -0.1 0.5 -0.0 1.2 -0.7 -0.6 -0.8 -1.2 -0.1
Birth weight 1.8 4.0 15.8 1.9 0.9 0.2 0.2 0.9 -2.7 -0.4 -4.0 -0.0 -3.3
Chronic bronchitis/emphysema (mother) 0.3 0.4 2.6 0.1 0.6 -0.5 -0.2 0.2 -0.1 0.6 0.2 0.5 1.6
High blood pressure (siblings) 2.9 4.2 9.6 -2.1 -1.1 0.1 0.6 -3.1 2.5 0.9 2.9 -1.3 3.1
Forced vital capacity (FVC), Best measure 0.9 3.3 11.9 2.0 0.7 -1.7 -1.8 -0.6 1.0 -1.7 -1.2 2.2 -3.5
Body fat percentage 2.0 7.8 30.0 0.1 -1.0 0.7 0.8 -0.6 5.5 1.0 4.3 1.6 4.8
Leg fat percentage (right) 1.9 7.1 22.5 -0.3 -1.2 1.2 1.2 -1.3 4.6 0.6 4.5 0.4 4.7
Arm fat-free mass (right) 1.8 9.1 32.3 5.7 -0.3 -0.1 -0.4 2.2 5.4 0.7 1.6 4.6 -0.5
Exposure to tobacco smoke outside home 1.8 2.4 6.4 -2.5 -0.5 -1.9 -1.7 -1.3 0.3 -1.9 0.8 -1.9 1.0
Comparative body size at age 10 1.2 3.3 8.4 0.6 0.9 2.9 2.6 -0.5 2.1 1.1 2.0 0.2 2.6
Number of full brothers 3.2 4.0 11.1 -3.3 -1.9 -0.7 -1.1 0.2 2.4 -1.0 3.1 -0.1 2.5
Worry too long after embarrassment 0.3 0.6 1.7 0.2 1.0 0.1 -0.0 0.7 0.2 1.3 -0.8 1.3 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.8 -1.3 -0.3 -0.3 -0.4 -0.5 0.8 0.7 -0.6 0.2 1.4
Wheeze or whistling in the chest in last year 1.3 2.2 9.7 -1.3 -1.4 0.4 0.2 -1.4 1.1 1.4 1.7 -0.9 3.1
Number of children fathered 0.2 0.2 0.5 0.6 -0.2 -0.5 -0.7 -0.0 0.0 0.1 -0.6 0.6 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 5.4 0.1 -0.2 -0.8 -0.9 -0.2 2.3 0.2 0.1 0.9 0.4
Age at first live birth 1.9 3.4 17.0 2.4 4.1 -1.4 -0.5 2.1 -0.5 0.2 -1.7 1.0 -0.4
Pulse wave peak to peak time 0.9 1.1 3.4 1.9 0.9 -1.2 -1.3 -1.0 0.1 -0.4 0.2 1.0 -0.9
Health satisfaction 0.9 1.1 4.3 -2.1 -2.0 -0.7 -0.9 -0.1 0.8 -0.3 0.3 -0.1 1.0
Shortness of breath walking on level ground 0.4 0.5 2.0 -0.5 -0.8 -0.8 -0.6 -1.4 -0.0 -0.7 -0.2 0.6 -0.7
Qualifications: College or University degree 0.8 2.6 6.5 1.6 2.5 -1.1 -1.2 2.1 -1.1 1.0 -1.4 1.1 -2.1
Eye problems/disorders: None of the above 0.9 1.1 4.3 -1.1 0.9 -1.0 -0.7 0.8 0.8 -0.7 1.1 0.3 2.1
Mouth/teeth dental problems: Loose teeth 1.3 1.5 5.0 -2.2 -0.3 -0.1 -0.2 -1.6 1.0 0.1 2.0 0.3 1.6
Emphysema/chronic bronchitis 0.4 0.5 2.3 0.9 0.3 0.7 0.4 -0.9 -0.1 -0.1 0.1 1.5 -0.5
Medication for pain relief, constipation, heartburn 2.3 3.9 18.1 1.4 1.0 -0.8 -0.5 0.4 -3.0 -0.8 -2.7 0.2 -4.3
Neck or shoulder pain in last month 2.0 2.8 13.2 -1.6 -3.6 1.4 0.7 -1.4 1.4 -1.0 1.8 -1.0 1.0
Medication: Blood pressure 0.6 1.0 3.1 -0.7 0.4 0.6 0.9 -0.2 1.7 0.4 1.3 0.6 1.8
Angina (self-reported) 0.4 0.5 1.1 -0.3 0.2 -1.1 -0.9 -0.2 0.6 0.9 0.3 0.7 0.9
Migraine (self-reported) 1.1 1.4 5.9 -1.1 0.5 -1.5 -1.1 0.1 -0.1 -2.4 1.4 -1.1 0.3
Medication: Ibuprofen 1.7 2.0 6.5 0.4 0.1 1.8 1.4 -0.4 2.0 0.6 1.8 0.2 2.6
Medication: Allopurinol 0.8 1.0 4.2 0.5 2.0 0.2 0.1 -0.1 -1.1 0.3 -0.7 1.5 -1.4
Medication: Omeprazole 1.0 1.2 4.4 -0.1 -2.1 1.1 0.7 0.2 1.1 1.2 0.2 -0.5 1.7
Medication: Seretide 50 evohaler 0.4 0.5 1.5 -0.4 1.1 0.3 0.2 0.3 -0.3 0.6 -0.9 0.8 1.2
Mean time to correctly identify matches 0.8 1.6 7.1 -0.3 -0.5 -0.8 -1.0 0.2 1.5 -1.2 2.7 1.4 -1.1
Heart disease (mother) 0.4 0.5 1.4 1.0 0.2 -1.2 -0.8 -0.3 -0.2 1.1 0.6 -0.0 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 6.7 -0.5 -1.3 0.9 1.3 -1.4 1.5 1.1 2.6 -0.6 1.3
Whole body fat mass 1.9 7.9 35.3 2.0 -0.8 0.7 0.7 0.4 5.9 1.1 3.8 2.8 3.7
Leg fat mass (right) 1.9 7.3 31.7 1.8 -1.0 0.6 0.5 -0.1 5.6 0.9 4.0 2.4 3.8
Arm predicted mass (right) 1.8 9.1 33.5 5.8 -0.2 -0.4 -0.6 2.4 5.2 0.7 1.5 4.6 -0.5
Pulse rate, automated reading 0.5 1.5 5.3 0.1 -0.7 -0.4 -0.5 1.3 1.3 2.3 -0.5 1.3 1.7
Alcohol intake frequency. 1.2 2.7 8.9 -2.5 -3.0 1.1 1.2 0.6 -1.0 0.7 0.5 -2.6 0.8
Comparative height size at age 10 0.8 4.6 16.2 4.0 1.1 -1.5 -1.3 2.7 1.4 0.2 -1.9 2.7 -2.1
Number of full sisters 0.3 0.3 1.6 -1.2 -1.3 0.2 0.3 -0.0 0.2 0.5 -0.2 0.1 -0.0
Suffer from ‘nerves’ 0.8 1.3 3.0 -1.4 1.5 -0.7 0.0 -1.7 0.2 1.3 -0.4 -0.8 1.6
Overall health rating 2.4 5.2 16.4 -2.7 -3.2 0.4 0.4 -1.2 3.1 1.0 2.5 -0.5 4.1
Chest pain or discomfort 0.7 1.1 2.7 -0.6 -1.1 -1.3 -1.6 -0.6 1.2 0.3 1.2 1.0 0.7
Had major operations 0.5 0.6 1.8 -0.6 -1.3 0.1 0.1 0.8 1.3 0.6 0.6 0.2 0.7
Age at last live birth 1.3 1.9 15.0 1.0 3.9 0.1 0.6 1.3 0.3 -0.2 -0.4 0.4 0.9
Family relationship satisfaction 0.3 0.3 1.0 -0.4 0.8 0.6 0.5 0.3 0.2 -0.8 -1.0 -0.3 -0.1
Leg pain on walking 1.5 1.8 4.5 -2.1 -2.0 0.1 -0.1 -2.0 1.6 0.1 1.4 -0.1 1.1
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 6.9 -1.7 -0.2 1.2 1.7 -2.6 -0.0 -0.8 0.4 -0.2 0.3
Commuting to job workplace: Car/motor vehicle 1.0 1.2 3.3 -0.6 -1.0 -1.4 -1.5 -0.4 0.1 1.8 0.1 0.5 1.6
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 4.2 0.2 -0.1 -0.4 -0.7 0.2 -0.2 -0.9 -1.3 2.0 -1.6
Medication: Aspirin 1.2 1.6 3.9 -2.0 -1.6 0.6 0.8 -1.3 0.6 -0.1 1.7 -1.5 1.3
Supplements: Vitamin C 0.9 1.0 3.1 -0.9 -0.3 0.4 0.3 -1.8 0.2 1.1 1.6 -0.3 1.4
Knee pain experienced in last month 1.6 2.4 4.8 -1.6 -2.1 0.7 0.7 -1.9 1.9 -0.6 2.2 -0.2 2.0
Hypertension (Self-reported) 2.1 6.0 14.1 -2.3 -1.0 3.0 3.5 -0.8 2.2 0.2 3.2 -1.4 3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 3.7 0.8 0.5 -0.9 -1.1 1.2 1.4 1.2 1.1 0.0 1.9
Illnesses of father: Heart disease 0.3 0.4 1.3 -0.7 1.1 0.3 0.7 0.0 0.1 0.5 1.2 -0.5 0.2
Illnesses of siblings: Diabetes 2.8 3.5 8.5 -1.8 -2.9 0.4 -0.1 -2.7 2.3 -0.6 2.9 -0.5 1.2
Smoking status: Previous 1.3 1.9 6.9 1.4 2.6 0.8 0.6 -2.0 0.1 0.9 -1.1 1.8 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 4.4 1.2 0.2 -0.5 -0.4 -0.8 2.1 -0.1 1.3 0.5 -1.1
Whole body fat-free mass 1.7 9.6 35.5 6.0 0.0 -0.6 -0.7 2.8 5.0 0.9 1.1 5.0 -0.8
Leg fat-free mass (right) 1.8 9.7 30.0 5.2 -0.0 -1.0 -0.9 2.4 5.5 1.9 1.6 5.1 0.8
Arm fat percentage (left) 2.3 9.0 33.1 -0.1 -1.2 0.6 0.5 -0.8 5.8 1.6 4.3 1.7 5.5
Average weekly red wine intake 1.1 1.7 4.8 1.7 1.0 2.2 1.6 0.9 0.9 -0.5 1.2 1.3 -0.2
Handedness (chirality/laterality): Left-handed 1.0 1.2 6.5 0.5 1.0 0.4 0.3 2.5 0.7 -0.5 -0.8 1.3 -1.1
Mood swings 0.1 0.2 1.1 -0.2 -0.7 -0.4 -0.2 -0.1 1.0 0.4 0.4 -0.2 0.3
Loneliness, isolation 0.5 0.6 3.0 0.0 -0.2 0.8 0.6 0.8 0.3 1.7 0.1 -0.1 1.2
Long-standing illness, disability or infirmity 1.1 1.7 6.3 -1.7 -1.6 0.4 0.4 -1.5 2.5 0.4 1.1 -0.6 1.0
Ever had bowel cancer screening 0.4 0.5 1.1 0.6 0.4 -0.6 -1.0 0.3 0.8 -1.0 0.1 0.9 -0.7
Diabetes diagnosed by doctor 3.1 5.1 17.9 -4.2 -2.1 0.7 0.7 -1.3 1.6 -1.4 3.0 -2.8 2.0
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.3 10.4 1.0 0.9 1.9 1.4 0.1 0.6 2.1 0.3 -0.1 3.2
Friendships satisfaction 0.5 0.6 2.7 -0.6 -0.2 -0.1 -0.6 -0.9 0.8 -1.6 0.1 -0.2 -0.8
Qualifications: nursing, teaching 0.9 1.5 4.7 2.2 1.5 -0.8 -1.1 1.4 0.0 0.1 -0.4 1.5 -1.2
Commuting to job workplace: Walk 1.5 1.6 5.9 1.2 1.6 -0.9 -1.0 1.1 0.9 -0.9 -0.1 1.2 -2.4
Eye problems/disorders: Cataract 1.1 1.2 6.3 1.3 -1.3 1.2 0.6 0.1 -0.2 -1.0 -0.1 -0.1 -2.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.7 -1.6 -1.0 0.3 0.2 -1.0 -0.3 1.6 0.3 -0.6 0.6
Medication for cholesterol 1.5 2.3 7.3 1.5 2.2 -1.0 -1.5 0.9 -0.5 0.5 -1.6 2.7 -1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 2.7 1.6 1.2 -0.3 -0.6 1.3 1.5 0.6 0.2 1.3 0.2
Back pain experienced in last month 1.7 2.5 7.9 -2.1 -1.9 0.7 0.2 0.7 2.5 -1.1 2.8 -0.3 0.5
Mineral and other dietary supplements 1.1 1.5 4.9 1.3 1.0 0.4 0.6 1.1 -1.6 1.7 -2.2 -0.0 0.6
Breast cancer (self-reported) 0.4 0.4 1.5 1.1 0.1 0.3 0.0 0.1 0.6 1.2 0.4 1.0 -0.3
Asthma (self-reported) 0.5 1.0 4.5 -2.1 -0.3 0.1 -0.0 -0.8 -0.9 -0.1 0.8 -1.7 0.8
Osteoporosis (self-reported) 0.9 1.1 4.9 -2.2 -1.0 0.6 0.3 0.2 -0.6 -1.0 -1.0 -1.3 0.4
Osteoarthritis (self-reported) 1.2 1.6 8.6 0.3 -2.9 1.0 0.9 0.2 0.4 1.8 0.3 -0.0 1.2
Medication: Aspirin 1.1 1.4 4.5 -2.1 -1.4 0.7 1.1 -0.8 0.3 0.1 1.3 -1.4 1.3
Medication: Gliclazide 2.6 2.9 7.9 -1.6 -0.7 1.9 1.9 -2.8 0.6 -0.7 2.8 -1.4 0.7
Illnesses of father: None of the above (group 1) 3.2 4.0 11.0 3.2 1.7 -1.1 -0.6 0.7 -2.5 1.0 -3.3 1.6 -1.9
Smoking status: Current 1.3 2.0 6.8 -2.3 -2.6 0.6 0.7 -0.2 0.7 -0.0 1.5 -1.8 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 7.4 -0.5 0.7 -2.7 -2.4 -1.3 0.6 0.4 -0.5 1.4 -1.6
Whole body water mass 1.7 9.9 35.3 5.9 -0.0 -0.6 -0.8 2.7 5.2 0.9 1.3 5.0 -0.8
Leg predicted mass (right) 1.8 9.6 29.9 5.2 -0.1 -1.0 -0.9 2.4 5.5 1.8 1.5 5.1 0.7
Arm fat mass (left) 2.1 8.7 38.1 1.9 -0.9 0.8 0.6 0.3 6.2 1.5 3.9 2.9 4.2
Number of self-reported non-cancer illnesses 1.7 3.0 8.4 -2.4 -0.9 1.0 1.2 -0.6 1.7 0.9 2.7 -1.1 2.9
Average weekly champagne plus white wine intake 1.4 1.9 7.0 0.9 2.3 -1.2 -1.6 2.6 0.2 -0.7 -0.3 0.9 -1.0
Miserableness 0.9 1.5 3.5 -1.2 0.7 0.0 0.3 0.2 1.8 1.9 1.2 1.2 1.8
Guilty feelings 0.2 0.4 1.0 -1.0 0.5 0.2 0.9 -0.4 0.3 0.6 0.4 0.5 0.6
Wears glasses or contact lenses 0.7 0.8 1.7 -1.2 -1.3 -0.8 -0.8 -0.5 -1.3 -0.9 0.0 -1.0 -0.3
Ever taken oral contraceptive pill 0.8 0.9 2.3 0.2 1.5 0.4 1.0 -0.8 -1.3 -1.3 -0.3 -0.1 -1.4
Hearing aid user 0.9 1.0 2.9 1.3 0.0 -0.5 -1.2 -1.0 1.7 0.9 0.1 1.6 0.3
Mother’s age at death 1.6 2.0 8.1 -0.3 0.5 0.0 -0.4 0.4 -2.8 -1.8 -0.9 -1.0 -2.4
Financial situation satisfaction 0.4 0.5 2.0 -1.4 -0.7 -0.3 0.2 -0.2 0.1 0.2 -1.0 -0.6 0.9
Tinnitus: Yes, now most or all of the time 1.9 2.2 6.5 0.0 -1.4 1.8 1.7 -0.3 0.7 -0.9 2.5 -1.7 1.7
Commuting to job workplace: Public transport 1.3 1.5 7.7 -0.2 0.4 0.6 0.7 0.1 -1.6 -1.5 -1.2 -0.6 -2.8
Eye problems/disorders: Glaucoma 0.6 0.7 3.9 0.2 0.1 -0.2 0.0 0.6 -0.3 1.5 -2.0 -0.8 -0.3
Medication: Blood pressure 1.2 2.2 5.4 -0.7 -1.7 1.5 1.7 -0.2 1.3 -0.1 1.6 -2.1 2.3
Pain type(s) experienced in last month: Hip pain 1.9 2.4 6.6 -1.2 -1.4 1.0 0.2 -1.0 2.6 -0.4 2.5 1.6 1.7
Supplements: Fish oil (including cod liver oil) 1.3 1.6 7.1 -0.9 -0.7 0.0 0.1 -1.7 1.5 -1.6 2.7 -0.1 -0.4
High cholesterol (Self-reported) 1.8 3.1 9.3 -1.1 0.7 1.5 2.0 -1.0 1.6 0.2 3.0 -1.5 2.9
Medication: Bendroflumethiazide 0.4 0.5 1.8 1.3 0.5 1.0 1.4 0.2 -0.0 0.1 0.3 -0.2 0.8
Medication: Paracetamol 1.1 1.7 6.3 -1.2 -1.0 -1.3 -1.4 0.6 0.8 0.1 0.5 -1.9 2.5
Medication: Lisinopril 0.9 1.1 3.1 -1.8 -1.0 -0.5 -0.4 -0.8 0.6 -1.4 1.1 -1.5 0.6
Medication: Atorvastatin 0.7 0.9 1.8 -1.0 -1.2 0.8 1.2 -0.7 -0.1 0.4 1.1 -1.3 0.8
Illnesses of father: High blood pressure 2.5 3.1 6.9 -2.4 -0.7 1.5 1.5 -0.5 2.1 0.2 2.4 -1.7 2.6
Alcohol drinker status: Never 0.6 0.7 4.1 0.7 0.5 -0.1 -0.3 2.0 -0.9 -0.3 -0.9 0.5 -0.5
Ever smoked 0.5 0.8 5.1 -0.1 0.6 -0.2 -0.4 -2.3 -0.2 0.6 -0.4 1.1 -0.8
Basal metabolic rate 1.7 9.6 31.5 5.6 -0.0 -0.4 -0.5 2.3 5.5 1.0 1.7 4.9 0.0
Leg fat percentage (left) 1.9 6.9 24.2 -0.1 -1.0 1.3 1.3 -1.1 4.5 0.8 4.2 0.5 4.9
Arm fat-free mass (left) 1.6 8.3 28.5 5.3 -0.3 -0.2 -0.3 2.3 5.2 0.4 1.5 4.5 -0.5
Number of operations (self-reported) 0.6 0.9 1.9 -0.6 -0.9 1.2 1.4 -0.4 0.9 1.2 1.1 -0.0 0.9
Average weekly beer plus cider intake 0.6 0.9 4.7 -0.2 0.0 -0.2 -0.2 -0.5 2.2 0.9 -0.3 1.7 0.7
Irritability 0.5 0.8 1.9 -0.3 0.5 -1.4 -0.8 -1.3 0.3 1.0 -0.8 1.2 -0.9
Risk taking 0.4 0.5 1.7 0.0 -1.0 -0.3 -0.8 0.6 0.9 0.7 0.2 1.3 0.1
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.4 -0.3 0.1 0.3 -0.3 0.6 0.1 -1.2 -0.4 -1.0 0.3
Fractured/broken bones in last 5 years 0.8 1.0 2.5 -0.0 -1.0 0.9 0.4 1.2 1.6 -0.9 1.2 0.2 1.4
Age started oral contraceptive pill 0.5 0.6 1.9 1.1 0.1 -0.1 -0.2 1.0 0.3 0.4 0.2 1.2 -1.4
Diastolic blood pressure, automated reading 1.4 4.3 13.3 -2.3 -2.1 -0.0 0.6 -1.8 2.8 0.2 3.6 -0.8 2.7
Ever depressed for a whole week 1.0 1.2 3.7 -0.1 0.8 -1.4 -1.1 1.3 0.6 1.9 -0.1 0.7 1.1
Unable to work because of sickness or disability 3.7 4.8 10.6 -2.9 -3.3 1.3 1.0 -0.6 0.8 1.8 2.4 -2.4 3.3
Commuting to job workplace: Cycle 0.2 0.3 1.2 0.3 0.4 0.2 -0.2 0.8 -0.1 1.1 -0.2 0.6 -0.7
Myopia 1.0 1.5 4.9 0.4 2.0 2.2 2.1 0.4 -0.6 -0.7 -0.0 -0.4 -0.1
Vascular/heart problems diagnosed by doctor 2.9 7.9 19.4 2.2 1.5 -3.6 -4.1 0.8 -2.3 -0.9 -3.7 1.5 -4.4
Cholesterol lowering medication 1.6 2.3 5.8 -2.3 -1.5 0.6 0.5 -1.2 1.9 -0.1 2.4 -0.7 1.9
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 6.7 -0.1 -2.6 1.4 1.0 0.3 1.3 1.3 0.2 0.1 2.3
Pain experienced in last month 2.0 3.3 8.9 1.7 2.3 -1.5 -0.9 1.0 -2.6 1.4 -3.0 0.7 -1.7
Supplements: Calcium 0.7 0.8 1.9 0.2 -0.5 0.7 0.4 -0.1 -1.3 -1.4 -1.4 -0.3 -1.2
Basal cell carcinoma (self-reported) 1.1 1.3 2.7 0.2 0.5 -1.2 -1.6 1.4 0.6 -1.1 -0.9 1.4 -1.4
Heart attack/myocardial infarction (self-reported) 0.6 0.8 2.0 -0.1 -0.3 -0.1 -0.7 1.3 1.4 1.0 1.1 0.6 1.0
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.0 -0.7 0.1 1.4 1.4 -0.3 0.3 0.8 0.1 -0.9 1.3
Heart disease (siblings) 3.8 4.7 11.4 -2.9 -2.1 1.6 2.0 -1.6 0.4 1.0 2.6 -2.3 3.4
Alcohol drinker status: Previous 1.1 1.3 3.7 -1.9 -1.7 -1.6 -1.4 0.7 0.5 0.3 0.7 -0.5 0.1
Pack years of smoking 1.0 1.5 7.9 -1.2 -2.8 -0.1 0.1 0.1 0.7 0.5 0.3 -1.2 1.8
Impedance of whole body 0.9 4.5 12.4 -2.9 1.5 0.2 0.5 -1.2 -3.5 -2.1 -1.4 -3.3 -1.7
Leg fat mass (left) 1.9 7.3 31.8 1.9 -0.7 0.6 0.5 -0.0 5.6 1.0 3.8 2.5 3.9
Arm predicted mass (left) 1.7 8.8 30.7 5.5 -0.4 -0.3 -0.5 2.4 5.2 0.3 1.5 4.6 -0.8