Hub : Genes

ARHGDIG

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.3010	0.0620	4.4e-07	-0.002	NA	0.037	NA	0.047	4.4e-01	NA	3.9e-03	NA	1.4e-03
2	GTEx	Esophagus Muscularis	0.1550	0.0570	3.0e-03	-0.001	NA	0.019	NA	0.012	3.8e-01	NA	2.5e-02	NA	5.5e-02
3	GTEx	Heart Atrial Appendage	0.2260	0.0670	1.2e-04	0.042	NA	0.088	NA	0.086	5.8e-03	NA	8.9e-05	NA	1.1e-04
4	GTEx	Heart Left Ventricle	0.2294	0.0580	7.3e-06	0.164	NA	0.128	NA	0.147	4.7e-09	NA	2.5e-07	NA	3.1e-08
5	GTEx	Muscle Skeletal	0.1978	0.0621	4.1e-04	0.009	NA	0.017	NA	0.015	3.6e-02	NA	7.0e-03	NA	1.1e-02
6	GTEx	Nerve Tibial	0.1333	0.0568	5.4e-03	0.074	NA	0.025	NA	0.072	6.1e-06	NA	6.1e-03	NA	8.0e-06
7	GTEx	Small Intestine Terminal Ileum	0.6200	0.1180	2.6e-04	-0.004	NA	0.065	NA	0.079	4.0e-01	NA	1.5e-02	NA	7.9e-03
8	GTEx	Stomach	0.1210	0.0500	8.6e-03	0.028	NA	0.055	NA	0.037	1.7e-02	NA	1.2e-03	NA	6.7e-03
9	TCGA	Prostate Adenocarcinoma	0.0766	0.0323	5.4e-05	0.004	0.041	0.042	NA	0.029	1.2e-01	4.1e-05	3.3e-05	NA	4.6e-04
10	TCGA	Thyroid Carcinoma	0.0920	0.0510	3.6e-03	0.007	0.032	0.011	NA	0.010	6.7e-02	3.7e-04	2.4e-02	NA	3.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.6	1.0	3.1	0.4	0.1	-1.2	-1.8	1.6	0.0	0.5	0.2	1.3	0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	1.8	0.6	0.8	-1.3	-1.3	0.6	0.0	0.6	-0.4	-0.2	1.1
Depressed Affect (Nagel 2018)	0.3	0.6	2.0	-0.9	-1.4	-0.8	-0.8	0.4	1.2	0.3	0.7	0.1	0.3
Depression (Nagel 2018)	0.8	1.3	3.9	-2.0	-0.8	0.7	0.4	-0.5	0.7	0.8	1.3	-0.7	1.9
Intelligence (Savage-Jansen 2018)	0.9	2.9	7.5	2.1	2.7	0.3	0.8	0.2	-2.3	0.1	-1.6	0.8	-2.7
Neuroticism (Nagel 2018)	0.4	0.9	5.5	-2.4	-0.9	-0.5	-0.0	-1.1	0.4	0.3	0.1	-1.0	0.5
Schizophrenia (2018)	0.3	0.6	2.1	0.4	0.9	-0.7	-0.3	-0.5	0.0	0.4	-0.8	-1.4	1.0
Schizophrenia vs Biploar Disorder	0.2	0.2	2.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.4	0.1
Worry (Nagel 2018)	1.5	3.2	13.1	-3.6	-0.7	0.4	1.1	-1.7	0.2	-0.1	0.3	-2.8	2.5
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	0.7	1.0	0.8	0.7	0.3	0.5	-0.0	0.7	0.9	-0.0
Alzheimer’s Disease (in father)	1.3	1.4	4.4	-1.8	0.6	1.1	1.1	-1.2	1.3	0.7	2.1	-0.0	0.4
Alzheimer’s Disease (including proxy)	0.7	1.1	4.1	0.3	1.2	1.9	2.0	-0.3	0.3	-0.3	0.9	0.5	-0.6
Crohns Disease (2017)	0.1	0.2	0.7	0.3	0.0	-0.1	0.5	-0.8	0.3	-0.7	0.7	0.4	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	1.1	0.6	0.1	0.5	0.6	0.1	0.9	-0.6	0.5	0.4
Ulcerative Colitis (UC)	0.7	1.3	3.6	1.1	1.2	-0.2	0.1	1.9	-0.5	1.7	-1.6	0.4	0.7
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.5	1.0	4.7	0.4	-0.2	-0.5	-0.6	0.2	1.5	-0.4	2.2	1.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.8	1.9	8.3	0.9	2.9	-0.3	0.2	1.2	-1.5	0.5	-1.1	0.9	-1.8
Breast Cancer	0.3	0.8	3.0	-0.4	0.8	-0.3	0.1	-1.2	-0.9	1.7	0.9	-0.4	0.6
Ovarian Cancer	0.1	0.1	0.3	0.6	-0.4	-0.3	-0.1	-0.4	-0.3	0.2	-0.5	-0.5	-0.1
Prostate Cancer	2.3	3.3	9.4	1.0	-0.2	-3.1	-2.9	0.8	-2.4	0.2	-2.3	-0.3	-1.6
Age at First Birth	1.7	2.4	4.5	1.3	2.1	-1.8	-2.1	1.5	0.6	-0.9	-1.3	1.2	-1.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.4	2.0	7.6	0.7	-0.7	1.4	1.5	1.5	0.0	-0.1	2.8	0.8	2.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.3	1.8	-0.1	0.0	-0.1	0.1	0.0	0.0	-1.3	1.2	-0.1	-0.1
Mean Putamen Volume	0.8	0.9	4.0	-1.0	-0.4	-0.5	-0.9	-0.8	0.0	-0.8	-0.7	-2.0	0.8
Fasting Glucose	0.6	0.7	1.3	0.6	-0.2	0.7	1.0	-0.2	-1.2	-0.9	0.9	-1.1	-0.5
HbA1C	0.8	0.9	2.0	-0.0	-0.8	1.4	1.1	0.9	0.2	-1.1	1.3	-0.4	-1.1
HDL Cholesterol	1.5	2.4	4.8	-2.2	-1.8	-1.9	-1.7	-1.0	0.0	-0.0	-2.1	-2.0	-0.7
LDL Cholesterol	0.9	1.4	3.1	-0.7	-1.7	1.7	1.8	1.2	0.0	0.5	0.7	0.3	1.5
Lupus	0.8	1.2	3.0	-1.0	-1.4	-1.6	-1.7	-0.8	-0.5	-1.0	0.2	-0.5	-1.1
Neuroticism (2016)	0.9	1.4	3.3	-1.7	-1.0	-1.2	-1.8	-0.5	1.8	0.4	0.8	0.6	0.7
Primary Biliary Cirrhosis	0.3	0.4	1.3	-0.5	-0.7	0.4	0.6	0.1	0.0	0.1	0.8	-1.1	0.9
Rheumatoid Arthritis	0.6	0.8	4.4	-0.2	-1.1	0.2	0.1	-0.4	0.0	-0.8	2.1	0.9	-0.6
Schizophrenia (2014)	0.5	1.0	4.1	0.6	-0.1	-0.4	-0.0	0.2	0.0	0.9	-1.6	-2.0	1.5
Triglycerides	1.0	1.6	5.3	0.2	0.9	2.3	2.1	0.9	0.0	-0.8	1.3	1.4	0.3
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	-0.2
Ulcerative Colitis	0.5	0.7	4.1	0.6	0.5	0.4	0.6	0.0	0.0	1.1	-2.0	0.4	0.5
Blood Eosinophil Count	0.1	0.9	3.9	-0.5	-0.2	0.2	0.2	0.9	-1.0	-0.4	-1.6	-2.0	0.8
Blood Platelet Count	0.4	5.1	18.1	-0.9	-1.7	4.2	3.3	0.0	0.7	-2.7	2.2	-2.3	-0.2
Blood Red Count	1.5	15.0	34.0	0.7	-5.6	5.8	4.5	-1.4	4.5	-5.1	3.9	-0.7	-0.0
Blood White Count	0.2	1.5	8.8	-1.4	-0.6	0.5	0.7	0.3	0.5	0.3	1.4	-0.8	3.0
Heel T-Score	1.2	9.9	39.2	6.3	2.5	-0.3	1.1	0.2	-0.8	2.0	1.8	4.1	-5.2
BMI	1.9	11.2	43.0	1.3	-1.6	0.3	-0.3	1.6	6.6	1.9	4.2	3.5	5.3
Height	0.8	15.9	59.0	7.7	3.7	-1.2	-0.9	3.1	3.6	-1.0	-0.5	5.2	-5.7
Waist Hip Ratio (WHR)	0.8	3.5	11.2	-2.8	-1.7	0.1	-0.1	-1.9	-0.0	-1.5	1.7	-3.3	2.1
Systolic Blood Pressure	0.6	2.9	9.2	-1.7	-1.2	-0.4	0.2	-0.5	2.3	0.9	2.9	0.7	3.0
Smoking Status	0.6	1.4	4.0	-1.3	-1.6	0.9	0.7	-2.0	1.4	0.9	0.6	0.2	1.4
Allergy or Eczema	0.3	0.9	2.9	-0.6	-0.6	-0.3	-0.5	-0.8	-1.1	-0.2	-1.7	-1.7	0.5
Cardiovascular Disease	2.3	7.8	24.4	-2.2	-0.7	2.4	3.1	-0.3	3.1	0.5	4.4	-1.7	4.9
Hypothyroidism (self reported)	0.6	1.4	5.5	-1.7	-1.0	0.6	1.1	-0.2	-1.5	-0.1	0.5	-2.3	0.7
Respiratory disease	0.5	1.1	5.9	-2.4	-0.1	-0.3	-0.5	-0.1	-0.4	-0.5	1.2	-1.6	0.8
Type 2 Diabetes (T2D) (2018)	3.1	5.9	16.0	-3.8	-2.0	1.5	1.3	-1.2	2.7	-2.1	4.0	-1.9	1.9
Lung FEV1/FVC ratio	0.1	0.4	2.0	-0.4	-0.2	-0.5	-0.4	0.2	1.4	-0.8	0.7	0.0	0.4
Lung FVC	0.4	2.0	8.0	-1.5	-0.3	-1.5	-0.8	-2.8	-1.3	-0.0	-1.2	0.1	-1.9
Neuroticism	0.9	2.1	8.2	-2.9	-0.9	-0.8	-0.1	-1.0	1.6	0.8	1.6	-0.3	2.1
Chronotype (morning person)	0.6	1.3	2.9	1.2	0.1	0.8	1.3	0.7	-1.3	1.6	-1.1	-0.2	1.7
Hair Pigment	0.1	2.4	8.0	-0.2	-0.4	1.8	1.5	-0.3	2.8	-0.3	2.4	0.4	2.1
Tanning	0.2	2.6	7.8	2.1	0.2	-2.5	-2.8	1.9	-0.1	0.6	-1.7	0.7	-0.6
Hand grip strength (left)	0.8	2.2	10.2	3.2	1.5	0.4	0.7	1.0	0.4	-0.7	-0.0	1.5	-2.2
Number of treatments/medications taken	1.7	3.0	9.1	-2.0	-1.5	0.1	0.1	-0.6	2.1	0.1	2.6	-1.7	3.0
Average weekly spirits intake	0.7	0.9	3.9	-1.4	-0.5	0.4	1.0	-0.2	1.1	-0.5	0.6	0.5	2.0
Sensitivity / hurt feelings	0.8	1.4	5.1	0.0	2.3	0.8	1.3	1.2	-1.1	0.9	-1.8	0.1	0.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	5.8	-0.5	1.1	1.4	1.4	-1.0	-0.0	1.6	0.4	-0.1	2.4
Hearing difficulty/problems: Yes	0.9	1.3	4.7	0.5	0.0	-0.2	-0.6	1.2	1.9	0.3	1.7	2.2	0.4
Relative age of first facial hair	0.8	1.7	5.8	-0.7	-0.6	-2.4	-2.4	-0.3	-0.4	-1.3	-0.4	-0.1	-1.5
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	7.5	-2.7	-2.6	-0.5	-0.6	-0.0	2.2	0.8	1.6	0.5	1.1
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.8	-2.0	-1.4	-1.1	-1.6	-0.1	1.3	0.1	0.9	0.6	0.6
Ever had hysterectomy (womb removed)	0.9	1.0	2.9	-0.8	-1.7	1.2	1.3	-0.1	-0.5	1.1	0.7	-0.8	0.9
Systolic blood pressure, automated reading	1.3	3.9	11.3	-2.0	-2.5	-0.7	-0.4	-0.7	2.6	1.3	3.4	0.7	2.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.7	-0.6	-1.4	-1.9	-1.5	-1.4	0.3	-0.0	0.4	-0.6	-0.3
Angina	0.4	0.5	1.7	-0.4	0.1	-1.3	-1.1	-0.1	0.6	0.8	0.4	0.8	0.5
Medication for hormone replacement therapy	0.4	0.4	1.2	-0.1	0.5	-0.9	-0.9	1.1	0.6	-0.5	0.4	0.3	0.4
Vitamin and mineral supplements	0.8	1.1	3.7	0.8	0.8	0.9	0.5	0.9	-1.0	-1.1	-1.9	-0.0	-1.4
Supplements: Zinc	1.0	1.1	2.5	-1.3	-1.6	0.8	1.2	-0.3	-1.1	1.0	0.5	-1.3	1.0
Medication: Co-codamol	1.7	2.0	9.7	-1.2	-3.1	0.5	0.4	-0.2	1.4	-0.8	1.9	-0.8	1.1
Medication: Metformin	2.8	4.0	14.4	-3.8	-2.6	0.6	0.8	-1.4	1.1	-1.7	1.9	-2.5	1.3
Diabetes (father)	5.6	7.0	16.8	-3.3	-4.1	0.8	1.1	-3.8	1.8	-2.0	2.8	-3.2	0.7
Diabetes (mother)	1.2	1.5	6.5	-2.6	-1.3	-0.1	-0.0	-1.2	-0.3	0.1	1.1	-1.7	1.1
Severe depression (siblings)	0.4	0.5	1.9	0.4	0.5	0.6	1.2	-0.1	-0.5	1.4	0.0	-0.3	-0.6
Pack years adult smoking proportion	1.1	1.6	8.5	-1.2	-2.9	0.1	0.3	-0.1	1.0	0.5	0.4	-1.1	1.8
Impedance of leg (right)	1.1	5.5	13.5	-2.7	1.3	1.0	1.0	-1.8	-3.6	-2.9	-1.0	-3.7	-2.3
Leg fat-free mass (left)	1.8	9.7	31.6	5.2	-0.1	-0.7	-0.7	2.3	5.6	1.6	2.0	5.0	0.8
Trunk fat percentage	1.8	7.2	29.8	0.3	-0.7	0.3	0.5	-0.2	5.5	1.1	4.0	1.9	4.5
Hand grip strength (right)	1.2	3.2	9.6	3.1	0.9	2.0	2.3	0.3	-1.4	-0.9	-0.5	0.2	-3.0
Townsend deprivation index at recruitment	2.4	3.4	6.8	-2.3	-2.1	1.6	1.2	-2.6	2.0	-0.5	2.5	-0.8	1.7
Current tobacco smoking	1.6	2.6	9.3	-2.2	-3.0	0.9	1.1	-0.5	0.9	0.4	1.5	-2.1	1.4
Average weekly fortified wine intake	0.6	0.7	2.2	-1.1	-1.5	-0.7	-0.2	-0.6	-1.2	-0.6	-0.6	-0.9	-0.3
Maternal smoking around birth	1.3	1.9	10.2	0.2	-0.2	0.0	-0.3	-1.0	3.2	0.0	1.9	0.4	2.0
Fed-up feelings	0.4	0.7	2.5	0.2	-0.6	-0.3	-0.9	-0.5	1.6	0.5	1.0	0.3	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	6.5	-2.5	-0.5	0.6	0.3	-1.9	0.9	0.1	1.5	-0.6	1.5
Relative age voice broke	0.5	0.7	1.7	-0.4	-0.9	-1.3	-1.3	0.6	-0.6	-0.1	-0.7	-0.7	-1.2
Taking other prescription medications	0.7	1.2	5.7	-0.2	-0.1	0.1	-0.2	1.5	1.7	0.6	0.2	-0.5	2.4
Age when periods started (menarche)	1.9	4.4	11.3	-1.6	-0.6	2.9	3.3	-1.4	-3.4	-0.5	-1.0	-2.9	0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.0	-0.1	0.0	-0.2	0.5	0.3	0.7	-0.5	0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.7	13.2	2.0	-0.2	0.2	0.8	-0.9	1.7	2.6	3.6	2.9	-0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.6	-0.3	0.3	0.2	0.2	-0.1	1.3	0.5	-0.1	0.8	0.6
Qualifications: CSEs or equivalent	1.6	2.1	6.8	-2.6	-1.3	0.4	0.5	-2.2	1.0	-0.0	1.6	-1.1	1.4
Serious illness, injury or assault to yourself	3.0	3.6	10.1	-2.1	-2.3	-1.4	-1.3	-1.0	2.6	-0.1	3.2	-0.8	2.0
High blood pressure	2.4	6.8	16.6	-1.9	-1.1	3.4	3.9	-0.6	2.3	0.5	3.4	-1.2	4.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.2	-1.3	-1.0	0.7	0.5	-1.4	-0.5	-1.0	-0.0	-2.5	1.3
Multivitamins +/- minerals	0.7	0.9	2.8	-0.7	-0.4	-1.0	-0.4	-0.0	1.4	-0.3	1.7	-0.5	1.3
Stomach or abdominal pain in last month	2.8	3.4	7.4	-2.1	-2.7	-0.7	-1.5	0.8	2.3	-1.7	2.7	-1.2	1.7
Supplements: Glucosamine	0.8	1.0	3.5	-0.4	-0.8	-0.4	-0.5	-0.8	1.5	-1.1	1.9	0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.3	0.5	1.1	0.1	-0.3	0.5	-0.2	-0.8	-0.7	-0.4	-0.6
Medication: Atenolol	1.1	1.3	5.3	-1.7	-0.1	0.1	-0.1	-1.2	0.9	-0.5	1.5	-0.5	2.3
Medication: Levothyroxine sodium	0.7	1.2	3.5	-1.9	-1.1	0.3	0.7	-0.9	-1.0	0.7	0.7	-1.7	0.8
Sitting height	1.4	9.9	33.1	5.4	1.2	-2.2	-1.7	2.8	0.9	-0.9	-1.6	3.9	-5.8
Chronic bronchitis/emphysema (father)	1.0	1.2	3.8	-0.3	-1.7	-1.3	-1.9	-0.1	1.4	-1.3	0.2	0.2	0.2
High blood pressure (mother)	2.0	2.8	6.0	-2.3	-0.6	1.9	2.3	-1.9	-0.6	-0.4	0.6	-2.5	1.6
Body mass index (BMI)	2.2	9.3	36.7	0.8	-2.0	0.6	0.4	-0.4	6.1	1.5	4.3	2.6	4.9
Impedance of leg (left)	1.1	5.4	12.8	-2.7	1.6	1.0	1.2	-1.8	-3.5	-2.7	-1.2	-3.6	-1.9
Leg predicted mass (left)	1.8	9.8	32.0	5.2	-0.3	-0.9	-0.9	2.2	5.7	1.6	1.9	5.1	0.7
Trunk fat mass	1.8	7.7	35.5	2.2	-0.3	0.3	0.3	0.7	6.0	1.0	3.7	2.9	3.5
Waist circumference	1.9	7.0	27.2	1.0	-1.8	1.0	0.9	0.2	5.2	0.5	4.3	1.4	4.0
Number of incorrect matches in round	1.0	1.7	6.9	0.5	0.4	-1.8	-2.6	1.9	1.5	0.0	-0.5	-0.3	0.8
Past tobacco smoking	0.7	1.2	3.7	-0.8	-1.9	-0.3	-0.1	1.9	-0.0	-1.1	0.7	-1.6	-0.1
Alcohol usually taken with meals	1.0	1.6	3.7	1.3	1.9	0.7	0.1	1.9	-0.3	-1.5	0.5	-1.5	-1.4
Nervous feelings	0.6	1.1	5.4	-2.3	0.7	-0.7	-0.0	-0.7	-0.0	0.4	0.3	-0.8	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	6.8	-2.5	-0.1	1.1	0.6	-2.1	0.5	1.7	-0.1	-1.2	2.6
Hearing difficulty/problems with background noise	0.5	0.8	1.7	-0.9	0.5	0.0	-0.3	1.3	0.9	-1.0	1.3	1.3	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	2.3	-0.5	1.0	-0.2	-0.2	1.1	0.9	-0.1	-0.2	1.5	-0.4
Had menopause	0.7	0.8	1.9	-0.2	0.1	-0.7	-1.1	0.5	1.1	1.4	1.2	1.2	-0.6
Had other major operations	0.5	0.6	3.2	-0.3	-1.2	-0.6	-0.5	0.4	0.2	1.8	0.8	-0.4	-0.0
Forced vital capacity (FVC)	0.6	2.2	8.5	1.4	1.4	-1.4	-1.2	-0.8	0.5	-1.5	-0.9	1.5	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.6	9.4	2.1	-0.4	-0.3	0.1	-1.0	0.6	2.3	3.1	2.3	-0.8
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.6	-1.9	-0.1	-0.8	-0.6	1.3	1.0	0.4	-0.4	0.6	1.4
Qualifications: None of the above	0.9	1.9	8.1	-2.2	-2.8	0.3	-0.3	-1.1	0.9	-1.0	1.4	-0.3	1.2
Financial difficulties in last 2 years	1.3	1.8	5.8	-0.4	-0.9	0.7	0.5	0.9	2.4	0.8	1.6	1.0	2.3
Mouth/teeth dental problems	0.8	1.2	3.3	1.3	1.4	-1.4	-0.9	0.3	-1.8	-0.2	-1.5	-0.6	-0.3
Heart attack	0.5	0.6	1.6	-0.1	-0.0	0.2	-0.3	1.3	1.1	1.1	0.9	0.3	1.0
Allergy	0.4	0.9	2.7	1.3	0.8	-0.8	-0.5	0.9	0.2	0.4	-0.4	1.6	-1.4
Pain all over the body in last month	0.8	0.8	3.0	-0.3	1.7	1.1	1.0	-0.6	1.2	-0.7	0.8	-0.2	0.2
Diabetes (self-reported)	2.2	3.4	12.4	-3.5	-1.7	0.8	0.8	-0.9	1.4	-1.0	2.8	-1.9	1.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-1.0	0.0	-0.4	-0.6	-0.8	-0.5	0.7	-0.4	-0.4	0.7
Medication: Ramipril	0.5	0.6	2.9	0.3	0.6	0.1	0.7	0.2	-0.3	1.7	0.5	-0.8	1.1
Medication: Simvastatin	1.8	2.7	9.5	-0.9	0.5	0.1	0.1	0.1	3.1	0.6	3.0	1.1	2.3
Fluid intelligence score	0.9	1.9	7.6	1.3	2.8	-1.6	-1.0	0.7	-1.1	1.2	-1.4	0.9	-1.0
Illnesses of siblings	4.0	5.6	12.1	3.2	2.1	0.0	-0.1	3.2	-2.3	-0.2	-3.3	1.6	-3.5
Neuroticism score	0.4	0.9	3.0	-1.4	0.8	-0.1	0.5	-0.0	0.9	1.5	0.5	0.0	1.7
Weight	1.9	9.3	41.6	3.9	-0.6	-0.1	-0.2	1.2	6.5	0.9	3.3	4.4	1.9
Impedance of arm (right)	0.6	3.0	9.7	-2.4	1.7	-0.2	-0.0	-0.4	-3.1	-1.2	-1.4	-2.3	-1.6
Arm fat percentage (right)	2.0	7.9	29.5	-0.1	-1.1	0.5	0.4	-0.6	5.4	1.5	4.1	1.7	5.1
Trunk fat-free mass	1.6	9.1	39.3	6.3	0.4	-0.4	-0.7	2.9	4.1	0.3	0.4	4.6	-2.0
Hip circumference	1.8	7.9	33.6	3.1	-1.3	0.1	-0.1	1.0	5.8	0.8	3.4	3.8	2.5
Time employed in main current job	1.7	1.9	8.9	-1.3	-1.1	-0.8	-0.7	0.9	1.2	1.5	0.0	-1.3	3.0
Alcohol intake versus 10 years previously	0.5	0.8	2.1	-1.5	-0.5	-1.3	-1.0	-1.5	-0.3	0.1	-0.9	-0.2	-0.2
Father’s age at death	1.3	1.8	5.2	1.1	1.5	0.4	0.2	2.3	-1.4	-0.2	-2.0	-0.2	-1.7
Worrier / anxious feelings	0.5	1.0	3.7	-1.9	0.6	0.6	1.1	-1.1	-0.3	-0.9	0.6	-1.4	-0.1
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	7.1	-1.9	-0.4	2.0	2.0	-0.6	0.7	1.0	1.8	-1.3	2.7
Falls in the last year	1.4	1.9	7.2	0.5	-0.5	-1.5	-2.2	0.7	2.7	0.8	0.7	0.7	1.4
Hair/balding pattern: Pattern 3	0.5	0.8	2.3	0.8	1.1	1.0	1.3	0.9	-1.5	0.0	0.2	0.1	-0.6
Number of live births	0.8	1.2	3.7	-0.3	-0.8	1.5	1.0	-0.2	1.1	0.9	1.9	-0.3	1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.7	0.6	1.6	-1.5	-1.2	-1.0	1.3	-1.4	0.3	1.3	-1.9
Pulse rate	0.7	1.1	4.2	-0.7	-1.6	0.3	0.3	-0.3	0.6	1.8	0.4	0.1	2.0
Happiness	0.5	0.7	2.8	-0.8	0.8	-1.0	-0.8	0.6	0.4	-1.7	-0.3	-0.2	-0.6
Noisy workplace	1.0	1.3	4.3	-0.7	-1.3	-0.1	0.1	-0.8	1.9	0.5	1.5	0.3	2.1
Qualifications: A levels/AS levels or equivalent	0.9	1.9	8.1	-0.0	2.8	-0.8	-0.4	0.6	-2.0	0.4	-1.7	0.4	-1.7
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	7.0	-1.3	-0.7	0.8	1.4	-2.0	-1.2	0.1	0.8	-2.6	0.1
Mouth/teeth dental problems: Dentures	0.6	1.0	2.7	-0.5	-1.5	0.0	0.1	1.5	1.6	-0.2	1.4	0.4	0.8
Asthma	0.3	0.6	2.9	-1.7	-0.2	-0.3	-0.4	-0.6	-0.7	0.2	0.5	-1.1	0.7
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	8.0	1.3	0.6	1.3	1.1	-0.5	2.4	1.7	1.9	1.5	2.8
Medication: Cholesterol lowering	0.9	1.4	5.0	-1.3	0.1	0.4	0.9	-0.3	1.6	-0.1	2.2	-0.6	1.9
Depression (self-reported)	0.7	0.9	2.5	-0.4	0.8	0.6	1.3	1.0	-0.4	1.4	-0.2	-0.5	1.6
Medication: Lansoprazole	0.8	0.9	2.5	-1.6	-0.5	-1.2	-1.1	0.3	0.9	0.2	0.9	0.2	1.5
Prospective memory result	1.5	1.8	6.3	-0.1	0.8	1.2	1.4	-1.1	-2.5	-0.7	-1.8	-1.6	-0.2
Lung cancer (father)	0.1	0.1	1.2	-0.1	0.0	-0.1	-0.2	-1.1	0.3	0.1	-0.1	-0.2	-0.2
Illnesses of mother	0.9	1.1	4.5	1.0	0.7	-0.6	-1.2	0.5	1.2	-0.6	-0.3	2.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	5.3	1.0	0.8	-2.0	-1.9	-0.7	2.1	-1.8	0.3	2.0	-2.3
Pulse wave Arterial Stiffness index	0.7	0.8	2.2	-1.5	-0.8	1.1	1.1	1.2	0.0	0.4	-0.4	-0.5	0.6
Impedance of arm (left)	0.6	2.7	8.0	-2.8	1.2	-0.2	-0.0	-0.7	-2.6	-1.1	-1.2	-2.4	-1.2
Arm fat mass (right)	1.9	7.9	34.9	1.7	-1.1	0.5	0.3	0.3	5.9	1.4	3.9	2.6	4.0
Trunk predicted mass	1.6	9.1	39.3	6.3	0.4	-0.3	-0.7	2.9	4.1	0.3	0.5	4.6	-1.9
Standing height	1.5	14.6	52.1	7.2	2.9	-1.6	-1.6	3.9	1.6	-1.0	-2.0	4.5	-6.1
Length of working week for main job	1.8	2.0	4.9	1.2	1.3	1.5	0.5	2.2	2.1	0.8	1.0	1.0	1.5
Exposure to tobacco smoke at home	0.7	0.7	2.2	-0.9	-1.5	-1.0	-0.7	-0.6	0.2	0.5	0.5	-0.3	1.4
Breastfed as a baby	1.2	1.5	4.2	-0.1	-0.4	1.5	1.1	-1.2	-1.7	-1.1	0.9	-2.0	-1.0
Tense / ‘highly strung’	0.6	1.0	3.6	-1.9	-0.1	-0.5	0.1	-0.6	0.6	-0.0	-0.6	-1.2	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.5	-1.1	1.2	-0.1	0.4	0.5	-0.2	1.6	-1.2	-0.7	1.9
Hair/balding pattern: Pattern 4	1.0	2.5	6.2	-1.2	-0.4	2.1	2.3	-0.3	-1.6	0.2	-0.9	-2.5	2.1
Birth weight of first child	1.0	1.9	7.4	1.8	-0.7	-0.6	0.1	0.7	-2.0	-0.2	-1.7	0.3	-2.7
Peak expiratory flow (PEF)	0.7	1.5	4.0	0.6	1.6	-1.5	-1.0	0.0	1.6	-2.0	1.1	0.8	-0.7
Pulse wave reflection index	0.4	0.5	2.1	-0.5	-0.1	1.2	1.0	1.5	-0.3	-0.1	-0.0	-0.5	-0.5
Ever highly irritable/argumentative for 2 days	1.5	1.8	8.2	-2.5	-1.1	-0.6	-0.4	0.1	0.6	-0.2	0.8	-0.5	2.9
Loud music exposure frequency	0.6	0.7	2.3	-0.9	0.0	0.6	1.2	-1.5	-0.3	-0.4	0.3	1.2	-0.5
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	8.6	2.2	1.4	-0.8	-0.4	0.3	-2.9	1.0	-2.3	-0.1	-0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.8	0.9	0.1	0.1	-0.3	-1.5	0.8	-0.9	0.0	1.7	-1.5
Blood clot in the leg (DVT)	0.6	0.7	2.5	-0.3	0.4	1.6	1.4	-0.3	0.3	1.1	-0.4	-0.3	0.9
Medication: Paracetamol	1.3	2.1	10.2	-1.4	-0.6	-1.3	-1.5	-0.0	1.4	0.9	0.7	-1.2	3.2
Headache pain in last month	0.6	1.0	2.9	-1.3	-1.1	-1.0	-0.9	-1.2	0.4	-0.2	-0.5	-1.7	0.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.5	0.7	-0.5	-0.6	-1.0	0.6	-1.1	-0.1	-1.3	-0.1	-1.6
Glaucoma (self-reported)	0.5	0.5	2.5	-0.6	-0.3	0.2	0.2	0.9	-0.4	0.7	-1.6	-1.0	-0.2
Gout (self-reported)	1.3	1.7	8.1	0.9	2.5	0.2	0.4	-0.0	0.2	1.0	-0.2	2.9	-0.7
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	5.4	-1.2	-0.8	0.5	1.0	-0.3	-1.3	0.3	0.3	-2.3	0.4
Medication: Amlodipine	0.7	1.0	2.6	-0.4	0.2	1.4	1.6	1.4	0.4	-0.8	1.1	-0.4	1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	-0.3	-0.1	0.5	-0.0	1.2	-0.7	-0.6	-0.8	-1.2	-0.1
Birth weight	1.8	4.0	15.8	1.9	0.9	0.2	0.2	0.9	-2.7	-0.4	-4.0	-0.0	-3.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	2.6	0.1	0.6	-0.5	-0.2	0.2	-0.1	0.6	0.2	0.5	1.6
High blood pressure (siblings)	2.9	4.2	9.6	-2.1	-1.1	0.1	0.6	-3.1	2.5	0.9	2.9	-1.3	3.1
Forced vital capacity (FVC), Best measure	0.9	3.3	11.9	2.0	0.7	-1.7	-1.8	-0.6	1.0	-1.7	-1.2	2.2	-3.5
Body fat percentage	2.0	7.8	30.0	0.1	-1.0	0.7	0.8	-0.6	5.5	1.0	4.3	1.6	4.8
Leg fat percentage (right)	1.9	7.1	22.5	-0.3	-1.2	1.2	1.2	-1.3	4.6	0.6	4.5	0.4	4.7
Arm fat-free mass (right)	1.8	9.1	32.3	5.7	-0.3	-0.1	-0.4	2.2	5.4	0.7	1.6	4.6	-0.5
Exposure to tobacco smoke outside home	1.8	2.4	6.4	-2.5	-0.5	-1.9	-1.7	-1.3	0.3	-1.9	0.8	-1.9	1.0
Comparative body size at age 10	1.2	3.3	8.4	0.6	0.9	2.9	2.6	-0.5	2.1	1.1	2.0	0.2	2.6
Number of full brothers	3.2	4.0	11.1	-3.3	-1.9	-0.7	-1.1	0.2	2.4	-1.0	3.1	-0.1	2.5
Worry too long after embarrassment	0.3	0.6	1.7	0.2	1.0	0.1	-0.0	0.7	0.2	1.3	-0.8	1.3	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.8	-1.3	-0.3	-0.3	-0.4	-0.5	0.8	0.7	-0.6	0.2	1.4
Wheeze or whistling in the chest in last year	1.3	2.2	9.7	-1.3	-1.4	0.4	0.2	-1.4	1.1	1.4	1.7	-0.9	3.1
Number of children fathered	0.2	0.2	0.5	0.6	-0.2	-0.5	-0.7	-0.0	0.0	0.1	-0.6	0.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	5.4	0.1	-0.2	-0.8	-0.9	-0.2	2.3	0.2	0.1	0.9	0.4
Age at first live birth	1.9	3.4	17.0	2.4	4.1	-1.4	-0.5	2.1	-0.5	0.2	-1.7	1.0	-0.4
Pulse wave peak to peak time	0.9	1.1	3.4	1.9	0.9	-1.2	-1.3	-1.0	0.1	-0.4	0.2	1.0	-0.9
Health satisfaction	0.9	1.1	4.3	-2.1	-2.0	-0.7	-0.9	-0.1	0.8	-0.3	0.3	-0.1	1.0
Shortness of breath walking on level ground	0.4	0.5	2.0	-0.5	-0.8	-0.8	-0.6	-1.4	-0.0	-0.7	-0.2	0.6	-0.7
Qualifications: College or University degree	0.8	2.6	6.5	1.6	2.5	-1.1	-1.2	2.1	-1.1	1.0	-1.4	1.1	-2.1
Eye problems/disorders: None of the above	0.9	1.1	4.3	-1.1	0.9	-1.0	-0.7	0.8	0.8	-0.7	1.1	0.3	2.1
Mouth/teeth dental problems: Loose teeth	1.3	1.5	5.0	-2.2	-0.3	-0.1	-0.2	-1.6	1.0	0.1	2.0	0.3	1.6
Emphysema/chronic bronchitis	0.4	0.5	2.3	0.9	0.3	0.7	0.4	-0.9	-0.1	-0.1	0.1	1.5	-0.5
Medication for pain relief, constipation, heartburn	2.3	3.9	18.1	1.4	1.0	-0.8	-0.5	0.4	-3.0	-0.8	-2.7	0.2	-4.3
Neck or shoulder pain in last month	2.0	2.8	13.2	-1.6	-3.6	1.4	0.7	-1.4	1.4	-1.0	1.8	-1.0	1.0
Medication: Blood pressure	0.6	1.0	3.1	-0.7	0.4	0.6	0.9	-0.2	1.7	0.4	1.3	0.6	1.8
Angina (self-reported)	0.4	0.5	1.1	-0.3	0.2	-1.1	-0.9	-0.2	0.6	0.9	0.3	0.7	0.9
Migraine (self-reported)	1.1	1.4	5.9	-1.1	0.5	-1.5	-1.1	0.1	-0.1	-2.4	1.4	-1.1	0.3
Medication: Ibuprofen	1.7	2.0	6.5	0.4	0.1	1.8	1.4	-0.4	2.0	0.6	1.8	0.2	2.6
Medication: Allopurinol	0.8	1.0	4.2	0.5	2.0	0.2	0.1	-0.1	-1.1	0.3	-0.7	1.5	-1.4
Medication: Omeprazole	1.0	1.2	4.4	-0.1	-2.1	1.1	0.7	0.2	1.1	1.2	0.2	-0.5	1.7
Medication: Seretide 50 evohaler	0.4	0.5	1.5	-0.4	1.1	0.3	0.2	0.3	-0.3	0.6	-0.9	0.8	1.2
Mean time to correctly identify matches	0.8	1.6	7.1	-0.3	-0.5	-0.8	-1.0	0.2	1.5	-1.2	2.7	1.4	-1.1
Heart disease (mother)	0.4	0.5	1.4	1.0	0.2	-1.2	-0.8	-0.3	-0.2	1.1	0.6	-0.0	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	6.7	-0.5	-1.3	0.9	1.3	-1.4	1.5	1.1	2.6	-0.6	1.3
Whole body fat mass	1.9	7.9	35.3	2.0	-0.8	0.7	0.7	0.4	5.9	1.1	3.8	2.8	3.7
Leg fat mass (right)	1.9	7.3	31.7	1.8	-1.0	0.6	0.5	-0.1	5.6	0.9	4.0	2.4	3.8
Arm predicted mass (right)	1.8	9.1	33.5	5.8	-0.2	-0.4	-0.6	2.4	5.2	0.7	1.5	4.6	-0.5
Pulse rate, automated reading	0.5	1.5	5.3	0.1	-0.7	-0.4	-0.5	1.3	1.3	2.3	-0.5	1.3	1.7
Alcohol intake frequency.	1.2	2.7	8.9	-2.5	-3.0	1.1	1.2	0.6	-1.0	0.7	0.5	-2.6	0.8
Comparative height size at age 10	0.8	4.6	16.2	4.0	1.1	-1.5	-1.3	2.7	1.4	0.2	-1.9	2.7	-2.1
Number of full sisters	0.3	0.3	1.6	-1.2	-1.3	0.2	0.3	-0.0	0.2	0.5	-0.2	0.1	-0.0
Suffer from ‘nerves’	0.8	1.3	3.0	-1.4	1.5	-0.7	0.0	-1.7	0.2	1.3	-0.4	-0.8	1.6
Overall health rating	2.4	5.2	16.4	-2.7	-3.2	0.4	0.4	-1.2	3.1	1.0	2.5	-0.5	4.1
Chest pain or discomfort	0.7	1.1	2.7	-0.6	-1.1	-1.3	-1.6	-0.6	1.2	0.3	1.2	1.0	0.7
Had major operations	0.5	0.6	1.8	-0.6	-1.3	0.1	0.1	0.8	1.3	0.6	0.6	0.2	0.7
Age at last live birth	1.3	1.9	15.0	1.0	3.9	0.1	0.6	1.3	0.3	-0.2	-0.4	0.4	0.9
Family relationship satisfaction	0.3	0.3	1.0	-0.4	0.8	0.6	0.5	0.3	0.2	-0.8	-1.0	-0.3	-0.1
Leg pain on walking	1.5	1.8	4.5	-2.1	-2.0	0.1	-0.1	-2.0	1.6	0.1	1.4	-0.1	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	6.9	-1.7	-0.2	1.2	1.7	-2.6	-0.0	-0.8	0.4	-0.2	0.3
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.3	-0.6	-1.0	-1.4	-1.5	-0.4	0.1	1.8	0.1	0.5	1.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	4.2	0.2	-0.1	-0.4	-0.7	0.2	-0.2	-0.9	-1.3	2.0	-1.6
Medication: Aspirin	1.2	1.6	3.9	-2.0	-1.6	0.6	0.8	-1.3	0.6	-0.1	1.7	-1.5	1.3
Supplements: Vitamin C	0.9	1.0	3.1	-0.9	-0.3	0.4	0.3	-1.8	0.2	1.1	1.6	-0.3	1.4
Knee pain experienced in last month	1.6	2.4	4.8	-1.6	-2.1	0.7	0.7	-1.9	1.9	-0.6	2.2	-0.2	2.0
Hypertension (Self-reported)	2.1	6.0	14.1	-2.3	-1.0	3.0	3.5	-0.8	2.2	0.2	3.2	-1.4	3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	3.7	0.8	0.5	-0.9	-1.1	1.2	1.4	1.2	1.1	0.0	1.9
Illnesses of father: Heart disease	0.3	0.4	1.3	-0.7	1.1	0.3	0.7	0.0	0.1	0.5	1.2	-0.5	0.2
Illnesses of siblings: Diabetes	2.8	3.5	8.5	-1.8	-2.9	0.4	-0.1	-2.7	2.3	-0.6	2.9	-0.5	1.2
Smoking status: Previous	1.3	1.9	6.9	1.4	2.6	0.8	0.6	-2.0	0.1	0.9	-1.1	1.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.4	1.2	0.2	-0.5	-0.4	-0.8	2.1	-0.1	1.3	0.5	-1.1
Whole body fat-free mass	1.7	9.6	35.5	6.0	0.0	-0.6	-0.7	2.8	5.0	0.9	1.1	5.0	-0.8
Leg fat-free mass (right)	1.8	9.7	30.0	5.2	-0.0	-1.0	-0.9	2.4	5.5	1.9	1.6	5.1	0.8
Arm fat percentage (left)	2.3	9.0	33.1	-0.1	-1.2	0.6	0.5	-0.8	5.8	1.6	4.3	1.7	5.5
Average weekly red wine intake	1.1	1.7	4.8	1.7	1.0	2.2	1.6	0.9	0.9	-0.5	1.2	1.3	-0.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	6.5	0.5	1.0	0.4	0.3	2.5	0.7	-0.5	-0.8	1.3	-1.1
Mood swings	0.1	0.2	1.1	-0.2	-0.7	-0.4	-0.2	-0.1	1.0	0.4	0.4	-0.2	0.3
Loneliness, isolation	0.5	0.6	3.0	0.0	-0.2	0.8	0.6	0.8	0.3	1.7	0.1	-0.1	1.2
Long-standing illness, disability or infirmity	1.1	1.7	6.3	-1.7	-1.6	0.4	0.4	-1.5	2.5	0.4	1.1	-0.6	1.0
Ever had bowel cancer screening	0.4	0.5	1.1	0.6	0.4	-0.6	-1.0	0.3	0.8	-1.0	0.1	0.9	-0.7
Diabetes diagnosed by doctor	3.1	5.1	17.9	-4.2	-2.1	0.7	0.7	-1.3	1.6	-1.4	3.0	-2.8	2.0
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	10.4	1.0	0.9	1.9	1.4	0.1	0.6	2.1	0.3	-0.1	3.2
Friendships satisfaction	0.5	0.6	2.7	-0.6	-0.2	-0.1	-0.6	-0.9	0.8	-1.6	0.1	-0.2	-0.8
Qualifications: nursing, teaching	0.9	1.5	4.7	2.2	1.5	-0.8	-1.1	1.4	0.0	0.1	-0.4	1.5	-1.2
Commuting to job workplace: Walk	1.5	1.6	5.9	1.2	1.6	-0.9	-1.0	1.1	0.9	-0.9	-0.1	1.2	-2.4
Eye problems/disorders: Cataract	1.1	1.2	6.3	1.3	-1.3	1.2	0.6	0.1	-0.2	-1.0	-0.1	-0.1	-2.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.7	-1.6	-1.0	0.3	0.2	-1.0	-0.3	1.6	0.3	-0.6	0.6
Medication for cholesterol	1.5	2.3	7.3	1.5	2.2	-1.0	-1.5	0.9	-0.5	0.5	-1.6	2.7	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.7	1.6	1.2	-0.3	-0.6	1.3	1.5	0.6	0.2	1.3	0.2
Back pain experienced in last month	1.7	2.5	7.9	-2.1	-1.9	0.7	0.2	0.7	2.5	-1.1	2.8	-0.3	0.5
Mineral and other dietary supplements	1.1	1.5	4.9	1.3	1.0	0.4	0.6	1.1	-1.6	1.7	-2.2	-0.0	0.6
Breast cancer (self-reported)	0.4	0.4	1.5	1.1	0.1	0.3	0.0	0.1	0.6	1.2	0.4	1.0	-0.3
Asthma (self-reported)	0.5	1.0	4.5	-2.1	-0.3	0.1	-0.0	-0.8	-0.9	-0.1	0.8	-1.7	0.8
Osteoporosis (self-reported)	0.9	1.1	4.9	-2.2	-1.0	0.6	0.3	0.2	-0.6	-1.0	-1.0	-1.3	0.4
Osteoarthritis (self-reported)	1.2	1.6	8.6	0.3	-2.9	1.0	0.9	0.2	0.4	1.8	0.3	-0.0	1.2
Medication: Aspirin	1.1	1.4	4.5	-2.1	-1.4	0.7	1.1	-0.8	0.3	0.1	1.3	-1.4	1.3
Medication: Gliclazide	2.6	2.9	7.9	-1.6	-0.7	1.9	1.9	-2.8	0.6	-0.7	2.8	-1.4	0.7
Illnesses of father: None of the above (group 1)	3.2	4.0	11.0	3.2	1.7	-1.1	-0.6	0.7	-2.5	1.0	-3.3	1.6	-1.9
Smoking status: Current	1.3	2.0	6.8	-2.3	-2.6	0.6	0.7	-0.2	0.7	-0.0	1.5	-1.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	7.4	-0.5	0.7	-2.7	-2.4	-1.3	0.6	0.4	-0.5	1.4	-1.6
Whole body water mass	1.7	9.9	35.3	5.9	-0.0	-0.6	-0.8	2.7	5.2	0.9	1.3	5.0	-0.8
Leg predicted mass (right)	1.8	9.6	29.9	5.2	-0.1	-1.0	-0.9	2.4	5.5	1.8	1.5	5.1	0.7
Arm fat mass (left)	2.1	8.7	38.1	1.9	-0.9	0.8	0.6	0.3	6.2	1.5	3.9	2.9	4.2
Number of self-reported non-cancer illnesses	1.7	3.0	8.4	-2.4	-0.9	1.0	1.2	-0.6	1.7	0.9	2.7	-1.1	2.9
Average weekly champagne plus white wine intake	1.4	1.9	7.0	0.9	2.3	-1.2	-1.6	2.6	0.2	-0.7	-0.3	0.9	-1.0
Miserableness	0.9	1.5	3.5	-1.2	0.7	0.0	0.3	0.2	1.8	1.9	1.2	1.2	1.8
Guilty feelings	0.2	0.4	1.0	-1.0	0.5	0.2	0.9	-0.4	0.3	0.6	0.4	0.5	0.6
Wears glasses or contact lenses	0.7	0.8	1.7	-1.2	-1.3	-0.8	-0.8	-0.5	-1.3	-0.9	0.0	-1.0	-0.3
Ever taken oral contraceptive pill	0.8	0.9	2.3	0.2	1.5	0.4	1.0	-0.8	-1.3	-1.3	-0.3	-0.1	-1.4
Hearing aid user	0.9	1.0	2.9	1.3	0.0	-0.5	-1.2	-1.0	1.7	0.9	0.1	1.6	0.3
Mother’s age at death	1.6	2.0	8.1	-0.3	0.5	0.0	-0.4	0.4	-2.8	-1.8	-0.9	-1.0	-2.4
Financial situation satisfaction	0.4	0.5	2.0	-1.4	-0.7	-0.3	0.2	-0.2	0.1	0.2	-1.0	-0.6	0.9
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.5	0.0	-1.4	1.8	1.7	-0.3	0.7	-0.9	2.5	-1.7	1.7
Commuting to job workplace: Public transport	1.3	1.5	7.7	-0.2	0.4	0.6	0.7	0.1	-1.6	-1.5	-1.2	-0.6	-2.8
Eye problems/disorders: Glaucoma	0.6	0.7	3.9	0.2	0.1	-0.2	0.0	0.6	-0.3	1.5	-2.0	-0.8	-0.3
Medication: Blood pressure	1.2	2.2	5.4	-0.7	-1.7	1.5	1.7	-0.2	1.3	-0.1	1.6	-2.1	2.3
Pain type(s) experienced in last month: Hip pain	1.9	2.4	6.6	-1.2	-1.4	1.0	0.2	-1.0	2.6	-0.4	2.5	1.6	1.7
Supplements: Fish oil (including cod liver oil)	1.3	1.6	7.1	-0.9	-0.7	0.0	0.1	-1.7	1.5	-1.6	2.7	-0.1	-0.4
High cholesterol (Self-reported)	1.8	3.1	9.3	-1.1	0.7	1.5	2.0	-1.0	1.6	0.2	3.0	-1.5	2.9
Medication: Bendroflumethiazide	0.4	0.5	1.8	1.3	0.5	1.0	1.4	0.2	-0.0	0.1	0.3	-0.2	0.8
Medication: Paracetamol	1.1	1.7	6.3	-1.2	-1.0	-1.3	-1.4	0.6	0.8	0.1	0.5	-1.9	2.5
Medication: Lisinopril	0.9	1.1	3.1	-1.8	-1.0	-0.5	-0.4	-0.8	0.6	-1.4	1.1	-1.5	0.6
Medication: Atorvastatin	0.7	0.9	1.8	-1.0	-1.2	0.8	1.2	-0.7	-0.1	0.4	1.1	-1.3	0.8
Illnesses of father: High blood pressure	2.5	3.1	6.9	-2.4	-0.7	1.5	1.5	-0.5	2.1	0.2	2.4	-1.7	2.6
Alcohol drinker status: Never	0.6	0.7	4.1	0.7	0.5	-0.1	-0.3	2.0	-0.9	-0.3	-0.9	0.5	-0.5
Ever smoked	0.5	0.8	5.1	-0.1	0.6	-0.2	-0.4	-2.3	-0.2	0.6	-0.4	1.1	-0.8
Basal metabolic rate	1.7	9.6	31.5	5.6	-0.0	-0.4	-0.5	2.3	5.5	1.0	1.7	4.9	0.0
Leg fat percentage (left)	1.9	6.9	24.2	-0.1	-1.0	1.3	1.3	-1.1	4.5	0.8	4.2	0.5	4.9
Arm fat-free mass (left)	1.6	8.3	28.5	5.3	-0.3	-0.2	-0.3	2.3	5.2	0.4	1.5	4.5	-0.5
Number of operations (self-reported)	0.6	0.9	1.9	-0.6	-0.9	1.2	1.4	-0.4	0.9	1.2	1.1	-0.0	0.9
Average weekly beer plus cider intake	0.6	0.9	4.7	-0.2	0.0	-0.2	-0.2	-0.5	2.2	0.9	-0.3	1.7	0.7
Irritability	0.5	0.8	1.9	-0.3	0.5	-1.4	-0.8	-1.3	0.3	1.0	-0.8	1.2	-0.9
Risk taking	0.4	0.5	1.7	0.0	-1.0	-0.3	-0.8	0.6	0.9	0.7	0.2	1.3	0.1
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.4	-0.3	0.1	0.3	-0.3	0.6	0.1	-1.2	-0.4	-1.0	0.3
Fractured/broken bones in last 5 years	0.8	1.0	2.5	-0.0	-1.0	0.9	0.4	1.2	1.6	-0.9	1.2	0.2	1.4
Age started oral contraceptive pill	0.5	0.6	1.9	1.1	0.1	-0.1	-0.2	1.0	0.3	0.4	0.2	1.2	-1.4
Diastolic blood pressure, automated reading	1.4	4.3	13.3	-2.3	-2.1	-0.0	0.6	-1.8	2.8	0.2	3.6	-0.8	2.7
Ever depressed for a whole week	1.0	1.2	3.7	-0.1	0.8	-1.4	-1.1	1.3	0.6	1.9	-0.1	0.7	1.1
Unable to work because of sickness or disability	3.7	4.8	10.6	-2.9	-3.3	1.3	1.0	-0.6	0.8	1.8	2.4	-2.4	3.3
Commuting to job workplace: Cycle	0.2	0.3	1.2	0.3	0.4	0.2	-0.2	0.8	-0.1	1.1	-0.2	0.6	-0.7
Myopia	1.0	1.5	4.9	0.4	2.0	2.2	2.1	0.4	-0.6	-0.7	-0.0	-0.4	-0.1
Vascular/heart problems diagnosed by doctor	2.9	7.9	19.4	2.2	1.5	-3.6	-4.1	0.8	-2.3	-0.9	-3.7	1.5	-4.4
Cholesterol lowering medication	1.6	2.3	5.8	-2.3	-1.5	0.6	0.5	-1.2	1.9	-0.1	2.4	-0.7	1.9
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	6.7	-0.1	-2.6	1.4	1.0	0.3	1.3	1.3	0.2	0.1	2.3
Pain experienced in last month	2.0	3.3	8.9	1.7	2.3	-1.5	-0.9	1.0	-2.6	1.4	-3.0	0.7	-1.7
Supplements: Calcium	0.7	0.8	1.9	0.2	-0.5	0.7	0.4	-0.1	-1.3	-1.4	-1.4	-0.3	-1.2
Basal cell carcinoma (self-reported)	1.1	1.3	2.7	0.2	0.5	-1.2	-1.6	1.4	0.6	-1.1	-0.9	1.4	-1.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	-0.1	-0.3	-0.1	-0.7	1.3	1.4	1.0	1.1	0.6	1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.0	-0.7	0.1	1.4	1.4	-0.3	0.3	0.8	0.1	-0.9	1.3
Heart disease (siblings)	3.8	4.7	11.4	-2.9	-2.1	1.6	2.0	-1.6	0.4	1.0	2.6	-2.3	3.4
Alcohol drinker status: Previous	1.1	1.3	3.7	-1.9	-1.7	-1.6	-1.4	0.7	0.5	0.3	0.7	-0.5	0.1
Pack years of smoking	1.0	1.5	7.9	-1.2	-2.8	-0.1	0.1	0.1	0.7	0.5	0.3	-1.2	1.8
Impedance of whole body	0.9	4.5	12.4	-2.9	1.5	0.2	0.5	-1.2	-3.5	-2.1	-1.4	-3.3	-1.7
Leg fat mass (left)	1.9	7.3	31.8	1.9	-0.7	0.6	0.5	-0.0	5.6	1.0	3.8	2.5	3.9
Arm predicted mass (left)	1.7	8.8	30.7	5.5	-0.4	-0.3	-0.5	2.4	5.2	0.3	1.5	4.6	-0.8