TWAS hub - ARHGDIG

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.3010	0.0620	4.4e-07	-0.002	NA	0.037	NA	0.047	4.4e-01	NA	3.9e-03	NA	1.4e-03
2	GTEx	Esophagus Muscularis	0.1550	0.0570	3.0e-03	-0.001	NA	0.019	NA	0.012	3.8e-01	NA	2.5e-02	NA	5.5e-02
3	GTEx	Heart Atrial Appendage	0.2260	0.0670	1.2e-04	0.042	NA	0.088	NA	0.086	5.8e-03	NA	8.9e-05	NA	1.1e-04
4	GTEx	Heart Left Ventricle	0.2294	0.0580	7.3e-06	0.164	NA	0.128	NA	0.147	4.7e-09	NA	2.5e-07	NA	3.1e-08
5	GTEx	Muscle Skeletal	0.1978	0.0621	4.1e-04	0.009	NA	0.017	NA	0.015	3.6e-02	NA	7.0e-03	NA	1.1e-02
6	GTEx	Nerve Tibial	0.1333	0.0568	5.4e-03	0.074	NA	0.025	NA	0.072	6.1e-06	NA	6.1e-03	NA	8.0e-06
7	GTEx	Small Intestine Terminal Ileum	0.6200	0.1180	2.6e-04	-0.004	NA	0.065	NA	0.079	4.0e-01	NA	1.5e-02	NA	7.9e-03
8	GTEx	Stomach	0.1210	0.0500	8.6e-03	0.028	NA	0.055	NA	0.037	1.7e-02	NA	1.2e-03	NA	6.7e-03
9	TCGA	Prostate Adenocarcinoma	0.0766	0.0323	5.4e-05	0.004	0.041	0.042	NA	0.029	1.2e-01	4.1e-05	3.3e-05	NA	4.6e-04
10	TCGA	Thyroid Carcinoma	0.0920	0.0510	3.6e-03	0.007	0.032	0.011	NA	0.010	6.7e-02	3.7e-04	2.4e-02	NA	3.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Diabetes (father)	5.6	7.0	16.8	-3.3	-4.1	0.8	1.1	-3.8	1.8	-2.0	2.8	-3.2	0.7
Illnesses of siblings	4.0	5.6	12.1	3.2	2.1	0.0	-0.1	3.2	-2.3	-0.2	-3.3	1.6	-3.5
Heart disease (siblings)	3.8	4.7	11.4	-2.9	-2.1	1.6	2.0	-1.6	0.4	1.0	2.6	-2.3	3.4
Unable to work because of sickness or disability	3.7	4.8	10.6	-2.9	-3.3	1.3	1.0	-0.6	0.8	1.8	2.4	-2.4	3.3
Number of full brothers	3.2	4.0	11.1	-3.3	-1.9	-0.7	-1.1	0.2	2.4	-1.0	3.1	-0.1	2.5
Illnesses of father: None of the above (group 1)	3.2	4.0	11.0	3.2	1.7	-1.1	-0.6	0.7	-2.5	1.0	-3.3	1.6	-1.9
Type 2 Diabetes (T2D) (2018)	3.1	5.9	16.0	-3.8	-2.0	1.5	1.3	-1.2	2.7	-2.1	4.0	-1.9	1.9
Diabetes diagnosed by doctor	3.1	5.1	17.9	-4.2	-2.1	0.7	0.7	-1.3	1.6	-1.4	3.0	-2.8	2.0
Serious illness, injury or assault to yourself	3.0	3.6	10.1	-2.1	-2.3	-1.4	-1.3	-1.0	2.6	-0.1	3.2	-0.8	2.0
High blood pressure (siblings)	2.9	4.2	9.6	-2.1	-1.1	0.1	0.6	-3.1	2.5	0.9	2.9	-1.3	3.1
Vascular/heart problems diagnosed by doctor	2.9	7.9	19.4	2.2	1.5	-3.6	-4.1	0.8	-2.3	-0.9	-3.7	1.5	-4.4
Medication: Metformin	2.8	4.0	14.4	-3.8	-2.6	0.6	0.8	-1.4	1.1	-1.7	1.9	-2.5	1.3
Stomach or abdominal pain in last month	2.8	3.4	7.4	-2.1	-2.7	-0.7	-1.5	0.8	2.3	-1.7	2.7	-1.2	1.7
Illnesses of siblings: Diabetes	2.8	3.5	8.5	-1.8	-2.9	0.4	-0.1	-2.7	2.3	-0.6	2.9	-0.5	1.2
Medication: Gliclazide	2.6	2.9	7.9	-1.6	-0.7	1.9	1.9	-2.8	0.6	-0.7	2.8	-1.4	0.7
Illnesses of father: High blood pressure	2.5	3.1	6.9	-2.4	-0.7	1.5	1.5	-0.5	2.1	0.2	2.4	-1.7	2.6
Townsend deprivation index at recruitment	2.4	3.4	6.8	-2.3	-2.1	1.6	1.2	-2.6	2.0	-0.5	2.5	-0.8	1.7
High blood pressure	2.4	6.8	16.6	-1.9	-1.1	3.4	3.9	-0.6	2.3	0.5	3.4	-1.2	4.1
Overall health rating	2.4	5.2	16.4	-2.7	-3.2	0.4	0.4	-1.2	3.1	1.0	2.5	-0.5	4.1
Prostate Cancer	2.3	3.3	9.4	1.0	-0.2	-3.1	-2.9	0.8	-2.4	0.2	-2.3	-0.3	-1.6
Cardiovascular Disease	2.3	7.8	24.4	-2.2	-0.7	2.4	3.1	-0.3	3.1	0.5	4.4	-1.7	4.9
Medication for pain relief, constipation, heartburn	2.3	3.9	18.1	1.4	1.0	-0.8	-0.5	0.4	-3.0	-0.8	-2.7	0.2	-4.3
Arm fat percentage (left)	2.3	9.0	33.1	-0.1	-1.2	0.6	0.5	-0.8	5.8	1.6	4.3	1.7	5.5
Body mass index (BMI)	2.2	9.3	36.7	0.8	-2.0	0.6	0.4	-0.4	6.1	1.5	4.3	2.6	4.9
Diabetes (self-reported)	2.2	3.4	12.4	-3.5	-1.7	0.8	0.8	-0.9	1.4	-1.0	2.8	-1.9	1.5
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	8.0	1.3	0.6	1.3	1.1	-0.5	2.4	1.7	1.9	1.5	2.8
Hypertension (Self-reported)	2.1	6.0	14.1	-2.3	-1.0	3.0	3.5	-0.8	2.2	0.2	3.2	-1.4	3.8
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	10.4	1.0	0.9	1.9	1.4	0.1	0.6	2.1	0.3	-0.1	3.2
Arm fat mass (left)	2.1	8.7	38.1	1.9	-0.9	0.8	0.6	0.3	6.2	1.5	3.9	2.9	4.2
High blood pressure (mother)	2.0	2.8	6.0	-2.3	-0.6	1.9	2.3	-1.9	-0.6	-0.4	0.6	-2.5	1.6
Arm fat percentage (right)	2.0	7.9	29.5	-0.1	-1.1	0.5	0.4	-0.6	5.4	1.5	4.1	1.7	5.1
Body fat percentage	2.0	7.8	30.0	0.1	-1.0	0.7	0.8	-0.6	5.5	1.0	4.3	1.6	4.8
Neck or shoulder pain in last month	2.0	2.8	13.2	-1.6	-3.6	1.4	0.7	-1.4	1.4	-1.0	1.8	-1.0	1.0
Pain experienced in last month	2.0	3.3	8.9	1.7	2.3	-1.5	-0.9	1.0	-2.6	1.4	-3.0	0.7	-1.7
BMI	1.9	11.2	43.0	1.3	-1.6	0.3	-0.3	1.6	6.6	1.9	4.2	3.5	5.3
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	7.5	-2.7	-2.6	-0.5	-0.6	-0.0	2.2	0.8	1.6	0.5	1.1
Age when periods started (menarche)	1.9	4.4	11.3	-1.6	-0.6	2.9	3.3	-1.4	-3.4	-0.5	-1.0	-2.9	0.2
Waist circumference	1.9	7.0	27.2	1.0	-1.8	1.0	0.9	0.2	5.2	0.5	4.3	1.4	4.0
Weight	1.9	9.3	41.6	3.9	-0.6	-0.1	-0.2	1.2	6.5	0.9	3.3	4.4	1.9
Arm fat mass (right)	1.9	7.9	34.9	1.7	-1.1	0.5	0.3	0.3	5.9	1.4	3.9	2.6	4.0
Leg fat percentage (right)	1.9	7.1	22.5	-0.3	-1.2	1.2	1.2	-1.3	4.6	0.6	4.5	0.4	4.7
Age at first live birth	1.9	3.4	17.0	2.4	4.1	-1.4	-0.5	2.1	-0.5	0.2	-1.7	1.0	-0.4
Whole body fat mass	1.9	7.9	35.3	2.0	-0.8	0.7	0.7	0.4	5.9	1.1	3.8	2.8	3.7
Leg fat mass (right)	1.9	7.3	31.7	1.8	-1.0	0.6	0.5	-0.1	5.6	0.9	4.0	2.4	3.8
Tinnitus: Yes, now most or all of the time	1.9	2.2	6.5	0.0	-1.4	1.8	1.7	-0.3	0.7	-0.9	2.5	-1.7	1.7
Pain type(s) experienced in last month: Hip pain	1.9	2.4	6.6	-1.2	-1.4	1.0	0.2	-1.0	2.6	-0.4	2.5	1.6	1.7
Leg fat percentage (left)	1.9	6.9	24.2	-0.1	-1.0	1.3	1.3	-1.1	4.5	0.8	4.2	0.5	4.9
Leg fat mass (left)	1.9	7.3	31.8	1.9	-0.7	0.6	0.5	-0.0	5.6	1.0	3.8	2.5	3.9
Leg fat-free mass (left)	1.8	9.7	31.6	5.2	-0.1	-0.7	-0.7	2.3	5.6	1.6	2.0	5.0	0.8
Trunk fat percentage	1.8	7.2	29.8	0.3	-0.7	0.3	0.5	-0.2	5.5	1.1	4.0	1.9	4.5
Leg predicted mass (left)	1.8	9.8	32.0	5.2	-0.3	-0.9	-0.9	2.2	5.7	1.6	1.9	5.1	0.7
Trunk fat mass	1.8	7.7	35.5	2.2	-0.3	0.3	0.3	0.7	6.0	1.0	3.7	2.9	3.5
Medication: Simvastatin	1.8	2.7	9.5	-0.9	0.5	0.1	0.1	0.1	3.1	0.6	3.0	1.1	2.3
Hip circumference	1.8	7.9	33.6	3.1	-1.3	0.1	-0.1	1.0	5.8	0.8	3.4	3.8	2.5
Length of working week for main job	1.8	2.0	4.9	1.2	1.3	1.5	0.5	2.2	2.1	0.8	1.0	1.0	1.5
Birth weight	1.8	4.0	15.8	1.9	0.9	0.2	0.2	0.9	-2.7	-0.4	-4.0	-0.0	-3.3
Arm fat-free mass (right)	1.8	9.1	32.3	5.7	-0.3	-0.1	-0.4	2.2	5.4	0.7	1.6	4.6	-0.5
Exposure to tobacco smoke outside home	1.8	2.4	6.4	-2.5	-0.5	-1.9	-1.7	-1.3	0.3	-1.9	0.8	-1.9	1.0
Arm predicted mass (right)	1.8	9.1	33.5	5.8	-0.2	-0.4	-0.6	2.4	5.2	0.7	1.5	4.6	-0.5
Leg fat-free mass (right)	1.8	9.7	30.0	5.2	-0.0	-1.0	-0.9	2.4	5.5	1.9	1.6	5.1	0.8
Leg predicted mass (right)	1.8	9.6	29.9	5.2	-0.1	-1.0	-0.9	2.4	5.5	1.8	1.5	5.1	0.7
High cholesterol (Self-reported)	1.8	3.1	9.3	-1.1	0.7	1.5	2.0	-1.0	1.6	0.2	3.0	-1.5	2.9
Age at First Birth	1.7	2.4	4.5	1.3	2.1	-1.8	-2.1	1.5	0.6	-0.9	-1.3	1.2	-1.9
Number of treatments/medications taken	1.7	3.0	9.1	-2.0	-1.5	0.1	0.1	-0.6	2.1	0.1	2.6	-1.7	3.0
Medication: Co-codamol	1.7	2.0	9.7	-1.2	-3.1	0.5	0.4	-0.2	1.4	-0.8	1.9	-0.8	1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.7	13.2	2.0	-0.2	0.2	0.8	-0.9	1.7	2.6	3.6	2.9	-0.1
Time employed in main current job	1.7	1.9	8.9	-1.3	-1.1	-0.8	-0.7	0.9	1.2	1.5	0.0	-1.3	3.0
Medication: Ibuprofen	1.7	2.0	6.5	0.4	0.1	1.8	1.4	-0.4	2.0	0.6	1.8	0.2	2.6
Whole body fat-free mass	1.7	9.6	35.5	6.0	0.0	-0.6	-0.7	2.8	5.0	0.9	1.1	5.0	-0.8
Back pain experienced in last month	1.7	2.5	7.9	-2.1	-1.9	0.7	0.2	0.7	2.5	-1.1	2.8	-0.3	0.5
Whole body water mass	1.7	9.9	35.3	5.9	-0.0	-0.6	-0.8	2.7	5.2	0.9	1.3	5.0	-0.8
Number of self-reported non-cancer illnesses	1.7	3.0	8.4	-2.4	-0.9	1.0	1.2	-0.6	1.7	0.9	2.7	-1.1	2.9
Basal metabolic rate	1.7	9.6	31.5	5.6	-0.0	-0.4	-0.5	2.3	5.5	1.0	1.7	4.9	0.0
Arm predicted mass (left)	1.7	8.8	30.7	5.5	-0.4	-0.3	-0.5	2.4	5.2	0.3	1.5	4.6	-0.8
Current tobacco smoking	1.6	2.6	9.3	-2.2	-3.0	0.9	1.1	-0.5	0.9	0.4	1.5	-2.1	1.4
Qualifications: CSEs or equivalent	1.6	2.1	6.8	-2.6	-1.3	0.4	0.5	-2.2	1.0	-0.0	1.6	-1.1	1.4
Trunk fat-free mass	1.6	9.1	39.3	6.3	0.4	-0.4	-0.7	2.9	4.1	0.3	0.4	4.6	-2.0
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.6	7.1	-1.9	-0.4	2.0	2.0	-0.6	0.7	1.0	1.8	-1.3	2.7
Trunk predicted mass	1.6	9.1	39.3	6.3	0.4	-0.3	-0.7	2.9	4.1	0.3	0.5	4.6	-1.9
Knee pain experienced in last month	1.6	2.4	4.8	-1.6	-2.1	0.7	0.7	-1.9	1.9	-0.6	2.2	-0.2	2.0
Mother’s age at death	1.6	2.0	8.1	-0.3	0.5	0.0	-0.4	0.4	-2.8	-1.8	-0.9	-1.0	-2.4
Arm fat-free mass (left)	1.6	8.3	28.5	5.3	-0.3	-0.2	-0.3	2.3	5.2	0.4	1.5	4.5	-0.5
Cholesterol lowering medication	1.6	2.3	5.8	-2.3	-1.5	0.6	0.5	-1.2	1.9	-0.1	2.4	-0.7	1.9
Worry (Nagel 2018)	1.5	3.2	13.1	-3.6	-0.7	0.4	1.1	-1.7	0.2	-0.1	0.3	-2.8	2.5
HDL Cholesterol	1.5	2.4	4.8	-2.2	-1.8	-1.9	-1.7	-1.0	0.0	-0.0	-2.1	-2.0	-0.7
Blood Red Count	1.5	15.0	34.0	0.7	-5.6	5.8	4.5	-1.4	4.5	-5.1	3.9	-0.7	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	6.8	-2.5	-0.1	1.1	0.6	-2.1	0.5	1.7	-0.1	-1.2	2.6
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	7.0	-1.3	-0.7	0.8	1.4	-2.0	-1.2	0.1	0.8	-2.6	0.1
Prospective memory result	1.5	1.8	6.3	-0.1	0.8	1.2	1.4	-1.1	-2.5	-0.7	-1.8	-1.6	-0.2
Standing height	1.5	14.6	52.1	7.2	2.9	-1.6	-1.6	3.9	1.6	-1.0	-2.0	4.5	-6.1
Ever highly irritable/argumentative for 2 days	1.5	1.8	8.2	-2.5	-1.1	-0.6	-0.4	0.1	0.6	-0.2	0.8	-0.5	2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	6.7	-0.5	-1.3	0.9	1.3	-1.4	1.5	1.1	2.6	-0.6	1.3
Leg pain on walking	1.5	1.8	4.5	-2.1	-2.0	0.1	-0.1	-2.0	1.6	0.1	1.4	-0.1	1.1
Commuting to job workplace: Walk	1.5	1.6	5.9	1.2	1.6	-0.9	-1.0	1.1	0.9	-0.9	-0.1	1.2	-2.4
Medication for cholesterol	1.5	2.3	7.3	1.5	2.2	-1.0	-1.5	0.9	-0.5	0.5	-1.6	2.7	-1.3
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	6.7	-0.1	-2.6	1.4	1.0	0.3	1.3	1.3	0.2	0.1	2.3
Body Mass Index (BMI) (2010)	1.4	2.0	7.6	0.7	-0.7	1.4	1.5	1.5	0.0	-0.1	2.8	0.8	2.0
Sitting height	1.4	9.9	33.1	5.4	1.2	-2.2	-1.7	2.8	0.9	-0.9	-1.6	3.9	-5.8
Falls in the last year	1.4	1.9	7.2	0.5	-0.5	-1.5	-2.2	0.7	2.7	0.8	0.7	0.7	1.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	8.6	2.2	1.4	-0.8	-0.4	0.3	-2.9	1.0	-2.3	-0.1	-0.7
Average weekly champagne plus white wine intake	1.4	1.9	7.0	0.9	2.3	-1.2	-1.6	2.6	0.2	-0.7	-0.3	0.9	-1.0
Diastolic blood pressure, automated reading	1.4	4.3	13.3	-2.3	-2.1	-0.0	0.6	-1.8	2.8	0.2	3.6	-0.8	2.7
Alzheimer’s Disease (in father)	1.3	1.4	4.4	-1.8	0.6	1.1	1.1	-1.2	1.3	0.7	2.1	-0.0	0.4
Systolic blood pressure, automated reading	1.3	3.9	11.3	-2.0	-2.5	-0.7	-0.4	-0.7	2.6	1.3	3.4	0.7	2.7
Maternal smoking around birth	1.3	1.9	10.2	0.2	-0.2	0.0	-0.3	-1.0	3.2	0.0	1.9	0.4	2.0
Financial difficulties in last 2 years	1.3	1.8	5.8	-0.4	-0.9	0.7	0.5	0.9	2.4	0.8	1.6	1.0	2.3
Father’s age at death	1.3	1.8	5.2	1.1	1.5	0.4	0.2	2.3	-1.4	-0.2	-2.0	-0.2	-1.7
Medication: Paracetamol	1.3	2.1	10.2	-1.4	-0.6	-1.3	-1.5	-0.0	1.4	0.9	0.7	-1.2	3.2
Gout (self-reported)	1.3	1.7	8.1	0.9	2.5	0.2	0.4	-0.0	0.2	1.0	-0.2	2.9	-0.7
Wheeze or whistling in the chest in last year	1.3	2.2	9.7	-1.3	-1.4	0.4	0.2	-1.4	1.1	1.4	1.7	-0.9	3.1
Mouth/teeth dental problems: Loose teeth	1.3	1.5	5.0	-2.2	-0.3	-0.1	-0.2	-1.6	1.0	0.1	2.0	0.3	1.6
Age at last live birth	1.3	1.9	15.0	1.0	3.9	0.1	0.6	1.3	0.3	-0.2	-0.4	0.4	0.9
Smoking status: Previous	1.3	1.9	6.9	1.4	2.6	0.8	0.6	-2.0	0.1	0.9	-1.1	1.8	-0.3
Smoking status: Current	1.3	2.0	6.8	-2.3	-2.6	0.6	0.7	-0.2	0.7	-0.0	1.5	-1.8	1.1
Commuting to job workplace: Public transport	1.3	1.5	7.7	-0.2	0.4	0.6	0.7	0.1	-1.6	-1.5	-1.2	-0.6	-2.8
Supplements: Fish oil (including cod liver oil)	1.3	1.6	7.1	-0.9	-0.7	0.0	0.1	-1.7	1.5	-1.6	2.7	-0.1	-0.4
Heel T-Score	1.2	9.9	39.2	6.3	2.5	-0.3	1.1	0.2	-0.8	2.0	1.8	4.1	-5.2
Diabetes (mother)	1.2	1.5	6.5	-2.6	-1.3	-0.1	-0.0	-1.2	-0.3	0.1	1.1	-1.7	1.1
Hand grip strength (right)	1.2	3.2	9.6	3.1	0.9	2.0	2.3	0.3	-1.4	-0.9	-0.5	0.2	-3.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	6.5	-2.5	-0.5	0.6	0.3	-1.9	0.9	0.1	1.5	-0.6	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.6	9.4	2.1	-0.4	-0.3	0.1	-1.0	0.6	2.3	3.1	2.3	-0.8
Breastfed as a baby	1.2	1.5	4.2	-0.1	-0.4	1.5	1.1	-1.2	-1.7	-1.1	0.9	-2.0	-1.0
Comparative body size at age 10	1.2	3.3	8.4	0.6	0.9	2.9	2.6	-0.5	2.1	1.1	2.0	0.2	2.6
Alcohol intake frequency.	1.2	2.7	8.9	-2.5	-3.0	1.1	1.2	0.6	-1.0	0.7	0.5	-2.6	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	6.9	-1.7	-0.2	1.2	1.7	-2.6	-0.0	-0.8	0.4	-0.2	0.3
Medication: Aspirin	1.2	1.6	3.9	-2.0	-1.6	0.6	0.8	-1.3	0.6	-0.1	1.7	-1.5	1.3
Osteoarthritis (self-reported)	1.2	1.6	8.6	0.3	-2.9	1.0	0.9	0.2	0.4	1.8	0.3	-0.0	1.2
Medication: Blood pressure	1.2	2.2	5.4	-0.7	-1.7	1.5	1.7	-0.2	1.3	-0.1	1.6	-2.1	2.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	5.8	-0.5	1.1	1.4	1.4	-1.0	-0.0	1.6	0.4	-0.1	2.4
Pack years adult smoking proportion	1.1	1.6	8.5	-1.2	-2.9	0.1	0.3	-0.1	1.0	0.5	0.4	-1.1	1.8
Impedance of leg (right)	1.1	5.5	13.5	-2.7	1.3	1.0	1.0	-1.8	-3.6	-2.9	-1.0	-3.7	-2.3
Medication: Atenolol	1.1	1.3	5.3	-1.7	-0.1	0.1	-0.1	-1.2	0.9	-0.5	1.5	-0.5	2.3
Impedance of leg (left)	1.1	5.4	12.8	-2.7	1.6	1.0	1.2	-1.8	-3.5	-2.7	-1.2	-3.6	-1.9
Migraine (self-reported)	1.1	1.4	5.9	-1.1	0.5	-1.5	-1.1	0.1	-0.1	-2.4	1.4	-1.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	3.7	0.8	0.5	-0.9	-1.1	1.2	1.4	1.2	1.1	0.0	1.9
Average weekly red wine intake	1.1	1.7	4.8	1.7	1.0	2.2	1.6	0.9	0.9	-0.5	1.2	1.3	-0.2
Long-standing illness, disability or infirmity	1.1	1.7	6.3	-1.7	-1.6	0.4	0.4	-1.5	2.5	0.4	1.1	-0.6	1.0
Eye problems/disorders: Cataract	1.1	1.2	6.3	1.3	-1.3	1.2	0.6	0.1	-0.2	-1.0	-0.1	-0.1	-2.5
Mineral and other dietary supplements	1.1	1.5	4.9	1.3	1.0	0.4	0.6	1.1	-1.6	1.7	-2.2	-0.0	0.6
Medication: Aspirin	1.1	1.4	4.5	-2.1	-1.4	0.7	1.1	-0.8	0.3	0.1	1.3	-1.4	1.3
Medication: Paracetamol	1.1	1.7	6.3	-1.2	-1.0	-1.3	-1.4	0.6	0.8	0.1	0.5	-1.9	2.5
Basal cell carcinoma (self-reported)	1.1	1.3	2.7	0.2	0.5	-1.2	-1.6	1.4	0.6	-1.1	-0.9	1.4	-1.4
Alcohol drinker status: Previous	1.1	1.3	3.7	-1.9	-1.7	-1.6	-1.4	0.7	0.5	0.3	0.7	-0.5	0.1
Triglycerides	1.0	1.6	5.3	0.2	0.9	2.3	2.1	0.9	0.0	-0.8	1.3	1.4	0.3
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.8	-2.0	-1.4	-1.1	-1.6	-0.1	1.3	0.1	0.9	0.6	0.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	3.7	-0.6	-1.4	-1.9	-1.5	-1.4	0.3	-0.0	0.4	-0.6	-0.3
Supplements: Zinc	1.0	1.1	2.5	-1.3	-1.6	0.8	1.2	-0.3	-1.1	1.0	0.5	-1.3	1.0
Chronic bronchitis/emphysema (father)	1.0	1.2	3.8	-0.3	-1.7	-1.3	-1.9	-0.1	1.4	-1.3	0.2	0.2	0.2
Number of incorrect matches in round	1.0	1.7	6.9	0.5	0.4	-1.8	-2.6	1.9	1.5	0.0	-0.5	-0.3	0.8
Alcohol usually taken with meals	1.0	1.6	3.7	1.3	1.9	0.7	0.1	1.9	-0.3	-1.5	0.5	-1.5	-1.4
Noisy workplace	1.0	1.3	4.3	-0.7	-1.3	-0.1	0.1	-0.8	1.9	0.5	1.5	0.3	2.1
Hair/balding pattern: Pattern 4	1.0	2.5	6.2	-1.2	-0.4	2.1	2.3	-0.3	-1.6	0.2	-0.9	-2.5	2.1
Birth weight of first child	1.0	1.9	7.4	1.8	-0.7	-0.6	0.1	0.7	-2.0	-0.2	-1.7	0.3	-2.7
Medication: Omeprazole	1.0	1.2	4.4	-0.1	-2.1	1.1	0.7	0.2	1.1	1.2	0.2	-0.5	1.7
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.3	-0.6	-1.0	-1.4	-1.5	-0.4	0.1	1.8	0.1	0.5	1.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	6.5	0.5	1.0	0.4	0.3	2.5	0.7	-0.5	-0.8	1.3	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	7.4	-0.5	0.7	-2.7	-2.4	-1.3	0.6	0.4	-0.5	1.4	-1.6
Ever depressed for a whole week	1.0	1.2	3.7	-0.1	0.8	-1.4	-1.1	1.3	0.6	1.9	-0.1	0.7	1.1
Myopia	1.0	1.5	4.9	0.4	2.0	2.2	2.1	0.4	-0.6	-0.7	-0.0	-0.4	-0.1
Pack years of smoking	1.0	1.5	7.9	-1.2	-2.8	-0.1	0.1	0.1	0.7	0.5	0.3	-1.2	1.8
Intelligence (Savage-Jansen 2018)	0.9	2.9	7.5	2.1	2.7	0.3	0.8	0.2	-2.3	0.1	-1.6	0.8	-2.7
LDL Cholesterol	0.9	1.4	3.1	-0.7	-1.7	1.7	1.8	1.2	0.0	0.5	0.7	0.3	1.5
Neuroticism (2016)	0.9	1.4	3.3	-1.7	-1.0	-1.2	-1.8	-0.5	1.8	0.4	0.8	0.6	0.7
Neuroticism	0.9	2.1	8.2	-2.9	-0.9	-0.8	-0.1	-1.0	1.6	0.8	1.6	-0.3	2.1
Hearing difficulty/problems: Yes	0.9	1.3	4.7	0.5	0.0	-0.2	-0.6	1.2	1.9	0.3	1.7	2.2	0.4
Ever had hysterectomy (womb removed)	0.9	1.0	2.9	-0.8	-1.7	1.2	1.3	-0.1	-0.5	1.1	0.7	-0.8	0.9
Qualifications: None of the above	0.9	1.9	8.1	-2.2	-2.8	0.3	-0.3	-1.1	0.9	-1.0	1.4	-0.3	1.2
Fluid intelligence score	0.9	1.9	7.6	1.3	2.8	-1.6	-1.0	0.7	-1.1	1.2	-1.4	0.9	-1.0
Qualifications: A levels/AS levels or equivalent	0.9	1.9	8.1	-0.0	2.8	-0.8	-0.4	0.6	-2.0	0.4	-1.7	0.4	-1.7
Medication: Cholesterol lowering	0.9	1.4	5.0	-1.3	0.1	0.4	0.9	-0.3	1.6	-0.1	2.2	-0.6	1.9
Illnesses of mother	0.9	1.1	4.5	1.0	0.7	-0.6	-1.2	0.5	1.2	-0.6	-0.3	2.1	-1.0
Forced vital capacity (FVC), Best measure	0.9	3.3	11.9	2.0	0.7	-1.7	-1.8	-0.6	1.0	-1.7	-1.2	2.2	-3.5
Pulse wave peak to peak time	0.9	1.1	3.4	1.9	0.9	-1.2	-1.3	-1.0	0.1	-0.4	0.2	1.0	-0.9
Health satisfaction	0.9	1.1	4.3	-2.1	-2.0	-0.7	-0.9	-0.1	0.8	-0.3	0.3	-0.1	1.0
Eye problems/disorders: None of the above	0.9	1.1	4.3	-1.1	0.9	-1.0	-0.7	0.8	0.8	-0.7	1.1	0.3	2.1
Supplements: Vitamin C	0.9	1.0	3.1	-0.9	-0.3	0.4	0.3	-1.8	0.2	1.1	1.6	-0.3	1.4
Qualifications: nursing, teaching	0.9	1.5	4.7	2.2	1.5	-0.8	-1.1	1.4	0.0	0.1	-0.4	1.5	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.7	1.6	1.2	-0.3	-0.6	1.3	1.5	0.6	0.2	1.3	0.2
Osteoporosis (self-reported)	0.9	1.1	4.9	-2.2	-1.0	0.6	0.3	0.2	-0.6	-1.0	-1.0	-1.3	0.4
Miserableness	0.9	1.5	3.5	-1.2	0.7	0.0	0.3	0.2	1.8	1.9	1.2	1.2	1.8
Hearing aid user	0.9	1.0	2.9	1.3	0.0	-0.5	-1.2	-1.0	1.7	0.9	0.1	1.6	0.3
Medication: Lisinopril	0.9	1.1	3.1	-1.8	-1.0	-0.5	-0.4	-0.8	0.6	-1.4	1.1	-1.5	0.6
Impedance of whole body	0.9	4.5	12.4	-2.9	1.5	0.2	0.5	-1.2	-3.5	-2.1	-1.4	-3.3	-1.7
Depression (Nagel 2018)	0.8	1.3	3.9	-2.0	-0.8	0.7	0.4	-0.5	0.7	0.8	1.3	-0.7	1.9
Verbal and Numeric Reasoning (VNR)	0.8	1.9	8.3	0.9	2.9	-0.3	0.2	1.2	-1.5	0.5	-1.1	0.9	-1.8
Mean Putamen Volume	0.8	0.9	4.0	-1.0	-0.4	-0.5	-0.9	-0.8	0.0	-0.8	-0.7	-2.0	0.8
HbA1C	0.8	0.9	2.0	-0.0	-0.8	1.4	1.1	0.9	0.2	-1.1	1.3	-0.4	-1.1
Lupus	0.8	1.2	3.0	-1.0	-1.4	-1.6	-1.7	-0.8	-0.5	-1.0	0.2	-0.5	-1.1
Height	0.8	15.9	59.0	7.7	3.7	-1.2	-0.9	3.1	3.6	-1.0	-0.5	5.2	-5.7
Waist Hip Ratio (WHR)	0.8	3.5	11.2	-2.8	-1.7	0.1	-0.1	-1.9	-0.0	-1.5	1.7	-3.3	2.1
Hand grip strength (left)	0.8	2.2	10.2	3.2	1.5	0.4	0.7	1.0	0.4	-0.7	-0.0	1.5	-2.2
Sensitivity / hurt feelings	0.8	1.4	5.1	0.0	2.3	0.8	1.3	1.2	-1.1	0.9	-1.8	0.1	0.3
Relative age of first facial hair	0.8	1.7	5.8	-0.7	-0.6	-2.4	-2.4	-0.3	-0.4	-1.3	-0.4	-0.1	-1.5
Vitamin and mineral supplements	0.8	1.1	3.7	0.8	0.8	0.9	0.5	0.9	-1.0	-1.1	-1.9	-0.0	-1.4
Supplements: Glucosamine	0.8	1.0	3.5	-0.4	-0.8	-0.4	-0.5	-0.8	1.5	-1.1	1.9	0.8	-0.8
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.6	-1.9	-0.1	-0.8	-0.6	1.3	1.0	0.4	-0.4	0.6	1.4
Mouth/teeth dental problems	0.8	1.2	3.3	1.3	1.4	-1.4	-0.9	0.3	-1.8	-0.2	-1.5	-0.6	-0.3
Pain all over the body in last month	0.8	0.8	3.0	-0.3	1.7	1.1	1.0	-0.6	1.2	-0.7	0.8	-0.2	0.2
Number of live births	0.8	1.2	3.7	-0.3	-0.8	1.5	1.0	-0.2	1.1	0.9	1.9	-0.3	1.4
Medication: Lansoprazole	0.8	0.9	2.5	-1.6	-0.5	-1.2	-1.1	0.3	0.9	0.2	0.9	0.2	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	5.3	1.0	0.8	-2.0	-1.9	-0.7	2.1	-1.8	0.3	2.0	-2.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.8	0.9	0.1	0.1	-0.3	-1.5	0.8	-0.9	0.0	1.7	-1.5
Qualifications: College or University degree	0.8	2.6	6.5	1.6	2.5	-1.1	-1.2	2.1	-1.1	1.0	-1.4	1.1	-2.1
Medication: Allopurinol	0.8	1.0	4.2	0.5	2.0	0.2	0.1	-0.1	-1.1	0.3	-0.7	1.5	-1.4
Mean time to correctly identify matches	0.8	1.6	7.1	-0.3	-0.5	-0.8	-1.0	0.2	1.5	-1.2	2.7	1.4	-1.1
Comparative height size at age 10	0.8	4.6	16.2	4.0	1.1	-1.5	-1.3	2.7	1.4	0.2	-1.9	2.7	-2.1
Suffer from ‘nerves’	0.8	1.3	3.0	-1.4	1.5	-0.7	0.0	-1.7	0.2	1.3	-0.4	-0.8	1.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	4.2	0.2	-0.1	-0.4	-0.7	0.2	-0.2	-0.9	-1.3	2.0	-1.6
Ever taken oral contraceptive pill	0.8	0.9	2.3	0.2	1.5	0.4	1.0	-0.8	-1.3	-1.3	-0.3	-0.1	-1.4
Fractured/broken bones in last 5 years	0.8	1.0	2.5	-0.0	-1.0	0.9	0.4	1.2	1.6	-0.9	1.2	0.2	1.4
Alzheimer’s Disease (including proxy)	0.7	1.1	4.1	0.3	1.2	1.9	2.0	-0.3	0.3	-0.3	0.9	0.5	-0.6
Ulcerative Colitis (UC)	0.7	1.3	3.6	1.1	1.2	-0.2	0.1	1.9	-0.5	1.7	-1.6	0.4	0.7
Average weekly spirits intake	0.7	0.9	3.9	-1.4	-0.5	0.4	1.0	-0.2	1.1	-0.5	0.6	0.5	2.0
Taking other prescription medications	0.7	1.2	5.7	-0.2	-0.1	0.1	-0.2	1.5	1.7	0.6	0.2	-0.5	2.4
Hayfever, allergic rhinitis or eczema	0.7	1.5	6.2	-1.3	-1.0	0.7	0.5	-1.4	-0.5	-1.0	-0.0	-2.5	1.3
Multivitamins +/- minerals	0.7	0.9	2.8	-0.7	-0.4	-1.0	-0.4	-0.0	1.4	-0.3	1.7	-0.5	1.3
Medication: Levothyroxine sodium	0.7	1.2	3.5	-1.9	-1.1	0.3	0.7	-0.9	-1.0	0.7	0.7	-1.7	0.8
Past tobacco smoking	0.7	1.2	3.7	-0.8	-1.9	-0.3	-0.1	1.9	-0.0	-1.1	0.7	-1.6	-0.1
Had menopause	0.7	0.8	1.9	-0.2	0.1	-0.7	-1.1	0.5	1.1	1.4	1.2	1.2	-0.6
Pulse rate	0.7	1.1	4.2	-0.7	-1.6	0.3	0.3	-0.3	0.6	1.8	0.4	0.1	2.0
Depression (self-reported)	0.7	0.9	2.5	-0.4	0.8	0.6	1.3	1.0	-0.4	1.4	-0.2	-0.5	1.6
Pulse wave Arterial Stiffness index	0.7	0.8	2.2	-1.5	-0.8	1.1	1.1	1.2	0.0	0.4	-0.4	-0.5	0.6
Exposure to tobacco smoke at home	0.7	0.7	2.2	-0.9	-1.5	-1.0	-0.7	-0.6	0.2	0.5	0.5	-0.3	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	3.5	-1.1	1.2	-0.1	0.4	0.5	-0.2	1.6	-1.2	-0.7	1.9
Peak expiratory flow (PEF)	0.7	1.5	4.0	0.6	1.6	-1.5	-1.0	0.0	1.6	-2.0	1.1	0.8	-0.7
Medication: Amlodipine	0.7	1.0	2.6	-0.4	0.2	1.4	1.6	1.4	0.4	-0.8	1.1	-0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	5.4	0.1	-0.2	-0.8	-0.9	-0.2	2.3	0.2	0.1	0.9	0.4
Chest pain or discomfort	0.7	1.1	2.7	-0.6	-1.1	-1.3	-1.6	-0.6	1.2	0.3	1.2	1.0	0.7
Wears glasses or contact lenses	0.7	0.8	1.7	-1.2	-1.3	-0.8	-0.8	-0.5	-1.3	-0.9	0.0	-1.0	-0.3
Medication: Atorvastatin	0.7	0.9	1.8	-1.0	-1.2	0.8	1.2	-0.7	-0.1	0.4	1.1	-1.3	0.8
Supplements: Calcium	0.7	0.8	1.9	0.2	-0.5	0.7	0.4	-0.1	-1.3	-1.4	-1.4	-0.3	-1.2
Bipolar Disorder (2018)	0.6	1.0	3.1	0.4	0.1	-1.2	-1.8	1.6	0.0	0.5	0.2	1.3	0.6
Fasting Glucose	0.6	0.7	1.3	0.6	-0.2	0.7	1.0	-0.2	-1.2	-0.9	0.9	-1.1	-0.5
Rheumatoid Arthritis	0.6	0.8	4.4	-0.2	-1.1	0.2	0.1	-0.4	0.0	-0.8	2.1	0.9	-0.6
Systolic Blood Pressure	0.6	2.9	9.2	-1.7	-1.2	-0.4	0.2	-0.5	2.3	0.9	2.9	0.7	3.0
Smoking Status	0.6	1.4	4.0	-1.3	-1.6	0.9	0.7	-2.0	1.4	0.9	0.6	0.2	1.4
Hypothyroidism (self reported)	0.6	1.4	5.5	-1.7	-1.0	0.6	1.1	-0.2	-1.5	-0.1	0.5	-2.3	0.7
Chronotype (morning person)	0.6	1.3	2.9	1.2	0.1	0.8	1.3	0.7	-1.3	1.6	-1.1	-0.2	1.7
Average weekly fortified wine intake	0.6	0.7	2.2	-1.1	-1.5	-0.7	-0.2	-0.6	-1.2	-0.6	-0.6	-0.9	-0.3
Nervous feelings	0.6	1.1	5.4	-2.3	0.7	-0.7	-0.0	-0.7	-0.0	0.4	0.3	-0.8	1.7
Forced vital capacity (FVC)	0.6	2.2	8.5	1.4	1.4	-1.4	-1.2	-0.8	0.5	-1.5	-0.9	1.5	-2.9
Impedance of arm (right)	0.6	3.0	9.7	-2.4	1.7	-0.2	-0.0	-0.4	-3.1	-1.2	-1.4	-2.3	-1.6
Mouth/teeth dental problems: Dentures	0.6	1.0	2.7	-0.5	-1.5	0.0	0.1	1.5	1.6	-0.2	1.4	0.4	0.8
Impedance of arm (left)	0.6	2.7	8.0	-2.8	1.2	-0.2	-0.0	-0.7	-2.6	-1.1	-1.2	-2.4	-1.2
Tense / ‘highly strung’	0.6	1.0	3.6	-1.9	-0.1	-0.5	0.1	-0.6	0.6	-0.0	-0.6	-1.2	1.8
Loud music exposure frequency	0.6	0.7	2.3	-0.9	0.0	0.6	1.2	-1.5	-0.3	-0.4	0.3	1.2	-0.5
Blood clot in the leg (DVT)	0.6	0.7	2.5	-0.3	0.4	1.6	1.4	-0.3	0.3	1.1	-0.4	-0.3	0.9
Headache pain in last month	0.6	1.0	2.9	-1.3	-1.1	-1.0	-0.9	-1.2	0.4	-0.2	-0.5	-1.7	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	5.4	-1.2	-0.8	0.5	1.0	-0.3	-1.3	0.3	0.3	-2.3	0.4
Medication: Blood pressure	0.6	1.0	3.1	-0.7	0.4	0.6	0.9	-0.2	1.7	0.4	1.3	0.6	1.8
Eye problems/disorders: Glaucoma	0.6	0.7	3.9	0.2	0.1	-0.2	0.0	0.6	-0.3	1.5	-2.0	-0.8	-0.3
Alcohol drinker status: Never	0.6	0.7	4.1	0.7	0.5	-0.1	-0.3	2.0	-0.9	-0.3	-0.9	0.5	-0.5
Number of operations (self-reported)	0.6	0.9	1.9	-0.6	-0.9	1.2	1.4	-0.4	0.9	1.2	1.1	-0.0	0.9
Average weekly beer plus cider intake	0.6	0.9	4.7	-0.2	0.0	-0.2	-0.2	-0.5	2.2	0.9	-0.3	1.7	0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	-0.1	-0.3	-0.1	-0.7	1.3	1.4	1.0	1.1	0.6	1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.0	-0.7	0.1	1.4	1.4	-0.3	0.3	0.8	0.1	-0.9	1.3
Reaction Time	0.5	1.0	4.7	0.4	-0.2	-0.5	-0.6	0.2	1.5	-0.4	2.2	1.1	-0.8
Schizophrenia (2014)	0.5	1.0	4.1	0.6	-0.1	-0.4	-0.0	0.2	0.0	0.9	-1.6	-2.0	1.5
Ulcerative Colitis	0.5	0.7	4.1	0.6	0.5	0.4	0.6	0.0	0.0	1.1	-2.0	0.4	0.5
Respiratory disease	0.5	1.1	5.9	-2.4	-0.1	-0.3	-0.5	-0.1	-0.4	-0.5	1.2	-1.6	0.8
Relative age voice broke	0.5	0.7	1.7	-0.4	-0.9	-1.3	-1.3	0.6	-0.6	-0.1	-0.7	-0.7	-1.2
Hearing difficulty/problems with background noise	0.5	0.8	1.7	-0.9	0.5	0.0	-0.3	1.3	0.9	-1.0	1.3	1.3	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	2.3	-0.5	1.0	-0.2	-0.2	1.1	0.9	-0.1	-0.2	1.5	-0.4
Had other major operations	0.5	0.6	3.2	-0.3	-1.2	-0.6	-0.5	0.4	0.2	1.8	0.8	-0.4	-0.0
Heart attack	0.5	0.6	1.6	-0.1	-0.0	0.2	-0.3	1.3	1.1	1.1	0.9	0.3	1.0
Medication: Ramipril	0.5	0.6	2.9	0.3	0.6	0.1	0.7	0.2	-0.3	1.7	0.5	-0.8	1.1
Alcohol intake versus 10 years previously	0.5	0.8	2.1	-1.5	-0.5	-1.3	-1.0	-1.5	-0.3	0.1	-0.9	-0.2	-0.2
Worrier / anxious feelings	0.5	1.0	3.7	-1.9	0.6	0.6	1.1	-1.1	-0.3	-0.9	0.6	-1.4	-0.1
Hair/balding pattern: Pattern 3	0.5	0.8	2.3	0.8	1.1	1.0	1.3	0.9	-1.5	0.0	0.2	0.1	-0.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.7	0.6	1.6	-1.5	-1.2	-1.0	1.3	-1.4	0.3	1.3	-1.9
Happiness	0.5	0.7	2.8	-0.8	0.8	-1.0	-0.8	0.6	0.4	-1.7	-0.3	-0.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.5	0.7	-0.5	-0.6	-1.0	0.6	-1.1	-0.1	-1.3	-0.1	-1.6
Glaucoma (self-reported)	0.5	0.5	2.5	-0.6	-0.3	0.2	0.2	0.9	-0.4	0.7	-1.6	-1.0	-0.2
Pulse rate, automated reading	0.5	1.5	5.3	0.1	-0.7	-0.4	-0.5	1.3	1.3	2.3	-0.5	1.3	1.7
Had major operations	0.5	0.6	1.8	-0.6	-1.3	0.1	0.1	0.8	1.3	0.6	0.6	0.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	4.4	1.2	0.2	-0.5	-0.4	-0.8	2.1	-0.1	1.3	0.5	-1.1
Loneliness, isolation	0.5	0.6	3.0	0.0	-0.2	0.8	0.6	0.8	0.3	1.7	0.1	-0.1	1.2
Friendships satisfaction	0.5	0.6	2.7	-0.6	-0.2	-0.1	-0.6	-0.9	0.8	-1.6	0.1	-0.2	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.7	-1.6	-1.0	0.3	0.2	-1.0	-0.3	1.6	0.3	-0.6	0.6
Asthma (self-reported)	0.5	1.0	4.5	-2.1	-0.3	0.1	-0.0	-0.8	-0.9	-0.1	0.8	-1.7	0.8
Ever smoked	0.5	0.8	5.1	-0.1	0.6	-0.2	-0.4	-2.3	-0.2	0.6	-0.4	1.1	-0.8
Irritability	0.5	0.8	1.9	-0.3	0.5	-1.4	-0.8	-1.3	0.3	1.0	-0.8	1.2	-0.9
Age started oral contraceptive pill	0.5	0.6	1.9	1.1	0.1	-0.1	-0.2	1.0	0.3	0.4	0.2	1.2	-1.4
Neuroticism (Nagel 2018)	0.4	0.9	5.5	-2.4	-0.9	-0.5	-0.0	-1.1	0.4	0.3	0.1	-1.0	0.5
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	0.7	1.0	0.8	0.7	0.3	0.5	-0.0	0.7	0.9	-0.0
Blood Platelet Count	0.4	5.1	18.1	-0.9	-1.7	4.2	3.3	0.0	0.7	-2.7	2.2	-2.3	-0.2
Lung FVC	0.4	2.0	8.0	-1.5	-0.3	-1.5	-0.8	-2.8	-1.3	-0.0	-1.2	0.1	-1.9
Angina	0.4	0.5	1.7	-0.4	0.1	-1.3	-1.1	-0.1	0.6	0.8	0.4	0.8	0.5
Medication for hormone replacement therapy	0.4	0.4	1.2	-0.1	0.5	-0.9	-0.9	1.1	0.6	-0.5	0.4	0.3	0.4
Severe depression (siblings)	0.4	0.5	1.9	0.4	0.5	0.6	1.2	-0.1	-0.5	1.4	0.0	-0.3	-0.6
Fed-up feelings	0.4	0.7	2.5	0.2	-0.6	-0.3	-0.9	-0.5	1.6	0.5	1.0	0.3	1.1
Allergy	0.4	0.9	2.7	1.3	0.8	-0.8	-0.5	0.9	0.2	0.4	-0.4	1.6	-1.4
Neuroticism score	0.4	0.9	3.0	-1.4	0.8	-0.1	0.5	-0.0	0.9	1.5	0.5	0.0	1.7
Pulse wave reflection index	0.4	0.5	2.1	-0.5	-0.1	1.2	1.0	1.5	-0.3	-0.1	-0.0	-0.5	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.5	-0.3	-0.1	0.5	-0.0	1.2	-0.7	-0.6	-0.8	-1.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.8	-1.3	-0.3	-0.3	-0.4	-0.5	0.8	0.7	-0.6	0.2	1.4
Shortness of breath walking on level ground	0.4	0.5	2.0	-0.5	-0.8	-0.8	-0.6	-1.4	-0.0	-0.7	-0.2	0.6	-0.7
Emphysema/chronic bronchitis	0.4	0.5	2.3	0.9	0.3	0.7	0.4	-0.9	-0.1	-0.1	0.1	1.5	-0.5
Angina (self-reported)	0.4	0.5	1.1	-0.3	0.2	-1.1	-0.9	-0.2	0.6	0.9	0.3	0.7	0.9
Medication: Seretide 50 evohaler	0.4	0.5	1.5	-0.4	1.1	0.3	0.2	0.3	-0.3	0.6	-0.9	0.8	1.2
Heart disease (mother)	0.4	0.5	1.4	1.0	0.2	-1.2	-0.8	-0.3	-0.2	1.1	0.6	-0.0	-0.3
Ever had bowel cancer screening	0.4	0.5	1.1	0.6	0.4	-0.6	-1.0	0.3	0.8	-1.0	0.1	0.9	-0.7
Breast cancer (self-reported)	0.4	0.4	1.5	1.1	0.1	0.3	0.0	0.1	0.6	1.2	0.4	1.0	-0.3
Financial situation satisfaction	0.4	0.5	2.0	-1.4	-0.7	-0.3	0.2	-0.2	0.1	0.2	-1.0	-0.6	0.9
Medication: Bendroflumethiazide	0.4	0.5	1.8	1.3	0.5	1.0	1.4	0.2	-0.0	0.1	0.3	-0.2	0.8
Risk taking	0.4	0.5	1.7	0.0	-1.0	-0.3	-0.8	0.6	0.9	0.7	0.2	1.3	0.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.8	0.6	0.8	-1.3	-1.3	0.6	0.0	0.6	-0.4	-0.2	1.1
Depressed Affect (Nagel 2018)	0.3	0.6	2.0	-0.9	-1.4	-0.8	-0.8	0.4	1.2	0.3	0.7	0.1	0.3
Schizophrenia (2018)	0.3	0.6	2.1	0.4	0.9	-0.7	-0.3	-0.5	0.0	0.4	-0.8	-1.4	1.0
Breast Cancer	0.3	0.8	3.0	-0.4	0.8	-0.3	0.1	-1.2	-0.9	1.7	0.9	-0.4	0.6
Primary Biliary Cirrhosis	0.3	0.4	1.3	-0.5	-0.7	0.4	0.6	0.1	0.0	0.1	0.8	-1.1	0.9
Allergy or Eczema	0.3	0.9	2.9	-0.6	-0.6	-0.3	-0.5	-0.8	-1.1	-0.2	-1.7	-1.7	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	1.6	-0.3	0.3	0.2	0.2	-0.1	1.3	0.5	-0.1	0.8	0.6
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.3	0.5	1.1	0.1	-0.3	0.5	-0.2	-0.8	-0.7	-0.4	-0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.1	-1.0	0.0	-0.4	-0.6	-0.8	-0.5	0.7	-0.4	-0.4	0.7
Asthma	0.3	0.6	2.9	-1.7	-0.2	-0.3	-0.4	-0.6	-0.7	0.2	0.5	-1.1	0.7
Chronic bronchitis/emphysema (mother)	0.3	0.4	2.6	0.1	0.6	-0.5	-0.2	0.2	-0.1	0.6	0.2	0.5	1.6
Worry too long after embarrassment	0.3	0.6	1.7	0.2	1.0	0.1	-0.0	0.7	0.2	1.3	-0.8	1.3	-0.2
Number of full sisters	0.3	0.3	1.6	-1.2	-1.3	0.2	0.3	-0.0	0.2	0.5	-0.2	0.1	-0.0
Family relationship satisfaction	0.3	0.3	1.0	-0.4	0.8	0.6	0.5	0.3	0.2	-0.8	-1.0	-0.3	-0.1
Illnesses of father: Heart disease	0.3	0.4	1.3	-0.7	1.1	0.3	0.7	0.0	0.1	0.5	1.2	-0.5	0.2
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.4	-0.3	0.1	0.3	-0.3	0.6	0.1	-1.2	-0.4	-1.0	0.3
Schizophrenia vs Biploar Disorder	0.2	0.2	2.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.4	0.1
Irritable Bowel Disease (IBD)	0.2	0.4	1.1	1.1	0.6	0.1	0.5	0.6	0.1	0.9	-0.6	0.5	0.4
Crohns Disease (2012)	0.2	0.3	1.8	-0.1	0.0	-0.1	0.1	0.0	0.0	-1.3	1.2	-0.1	-0.1
Blood White Count	0.2	1.5	8.8	-1.4	-0.6	0.5	0.7	0.3	0.5	0.3	1.4	-0.8	3.0
Tanning	0.2	2.6	7.8	2.1	0.2	-2.5	-2.8	1.9	-0.1	0.6	-1.7	0.7	-0.6
Number of children fathered	0.2	0.2	0.5	0.6	-0.2	-0.5	-0.7	-0.0	0.0	0.1	-0.6	0.6	0.2
Guilty feelings	0.2	0.4	1.0	-1.0	0.5	0.2	0.9	-0.4	0.3	0.6	0.4	0.5	0.6
Commuting to job workplace: Cycle	0.2	0.3	1.2	0.3	0.4	0.2	-0.2	0.8	-0.1	1.1	-0.2	0.6	-0.7
Crohns Disease (2017)	0.1	0.2	0.7	0.3	0.0	-0.1	0.5	-0.8	0.3	-0.7	0.7	0.4	-0.5
Ovarian Cancer	0.1	0.1	0.3	0.6	-0.4	-0.3	-0.1	-0.4	-0.3	0.2	-0.5	-0.5	-0.1
Blood Eosinophil Count	0.1	0.9	3.9	-0.5	-0.2	0.2	0.2	0.9	-1.0	-0.4	-1.6	-2.0	0.8
Lung FEV1/FVC ratio	0.1	0.4	2.0	-0.4	-0.2	-0.5	-0.4	0.2	1.4	-0.8	0.7	0.0	0.4
Hair Pigment	0.1	2.4	8.0	-0.2	-0.4	1.8	1.5	-0.3	2.8	-0.3	2.4	0.4	2.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.0	-0.1	0.0	-0.2	0.5	0.3	0.7	-0.5	0.5	0.3
Lung cancer (father)	0.1	0.1	1.2	-0.1	0.0	-0.1	-0.2	-1.1	0.3	0.1	-0.1	-0.2	-0.2
Mood swings	0.1	0.2	1.1	-0.2	-0.7	-0.4	-0.2	-0.1	1.0	0.4	0.4	-0.2	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.2	-0.2

Hub : Genes

ARHGDIG

Models

Trait associations