Best TWAS P=2.98e-14 · Best GWAS P=3.68e-14 conditioned to 0.708
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | C17orf65 | 0.07 | 0.06 | enet | 15 | 0.07 | 4.5e-09 | 6.7 | -6.1 | 1.2e-09 | -0.84 | 0.35 | 0.65 | FALSE |
2 | GTEx | Adipose Subcutaneous | TUBG2 | 0.21 | 0.18 | enet | 17 | 0.26 | 2.1e-21 | -4.3 | -5.5 | 4.2e-08 | -0.05 | 0.92 | 0.08 | FALSE |
3 | GTEx | Adipose Subcutaneous | ASB16-AS1 | 0.12 | 0.05 | enet | 16 | 0.05 | 3.7e-05 | 6.8 | -6.0 | 1.7e-09 | -0.75 | 0.12 | 0.70 | FALSE |
4 | GTEx | Adipose Visceral Omentum | ASB16-AS1 | 0.14 | 0.12 | lasso | 5 | 0.10 | 9.8e-06 | 6.2 | -6.3 | 2.3e-10 | -0.84 | 0.41 | 0.54 | FALSE |
5 | GTEx | Artery Tibial | HSD17B1 | 0.12 | 0.07 | lasso | 9 | 0.07 | 4.4e-06 | -5.0 | -5.2 | 1.9e-07 | -0.02 | 0.30 | 0.69 | FALSE |
6 | GTEx | Artery Tibial | RP11-400F19.6 | 0.07 | 0.01 | lasso | 5 | 0.01 | 3.0e-02 | 6.6 | -6.4 | 1.6e-10 | -0.09 | 0.00 | 0.99 | FALSE |
7 | GTEx | Brain Caudate basal ganglia | TUBG2 | 0.39 | 0.24 | enet | 45 | 0.25 | 7.7e-08 | -5.0 | -6.1 | 9.4e-10 | -0.05 | 0.12 | 0.87 | FALSE |
8 | GTEx | Breast Mammary Tissue (Female) | ASB16-AS1 | 0.08 | 0.04 | lasso | 2 | 0.06 | 7.9e-03 | 6.2 | -6.4 | 2.0e-10 | -0.85 | 0.06 | 0.50 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | TUBG2 | 0.16 | 0.18 | lasso | 4 | 0.17 | 6.5e-13 | -5.0 | -5.2 | 1.5e-07 | -0.02 | 0.97 | 0.03 | FALSE |
10 | GTEx | Cells Transformed fibroblasts | ASB16 | 0.14 | 0.14 | lasso | 3 | 0.12 | 2.0e-09 | 6.8 | -6.8 | 1.2e-11 | -0.89 | 0.22 | 0.78 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | ASB16-AS1 | 0.17 | 0.17 | lasso | 4 | 0.16 | 2.3e-12 | 6.8 | -6.5 | 6.5e-11 | -0.83 | 0.26 | 0.74 | FALSE |
12 | GTEx | Esophagus Mucosa | TUBG2 | 0.09 | 0.09 | lasso | 4 | 0.11 | 5.5e-08 | -5.0 | -6.3 | 2.2e-10 | -0.04 | 0.02 | 0.98 | FALSE |
13 | GTEx | Esophagus Mucosa | BECN1 | 0.24 | 0.08 | lasso | 4 | 0.05 | 5.1e-04 | 5.5 | 5.1 | 2.8e-07 | 0.09 | 0.11 | 0.68 | FALSE |
14 | GTEx | Esophagus Mucosa | ASB16 | 0.10 | 0.10 | lasso | 4 | 0.08 | 8.2e-06 | 6.8 | -6.8 | 1.2e-11 | -0.89 | 0.10 | 0.90 | FALSE |
15 | GTEx | Esophagus Mucosa | ASB16-AS1 | 0.11 | 0.08 | enet | 16 | 0.07 | 3.7e-05 | 4.9 | -6.1 | 1.4e-09 | -0.78 | 0.27 | 0.71 | FALSE |
16 | GTEx | Esophagus Muscularis | TUBG2 | 0.14 | 0.16 | enet | 17 | 0.06 | 2.1e-04 | -5.0 | -5.3 | 9.6e-08 | -0.03 | 0.95 | 0.05 | FALSE |
17 | GTEx | Esophagus Muscularis | NAGLU | 0.29 | 0.09 | lasso | 5 | 0.07 | 6.2e-05 | 5.5 | -5.4 | 6.8e-08 | -0.08 | 0.27 | 0.64 | FALSE |
18 | GTEx | Esophagus Muscularis | RP11-400F19.8 | 0.17 | 0.05 | lasso | 4 | 0.02 | 3.9e-02 | 5.5 | -5.8 | 7.9e-09 | -0.05 | 0.04 | 0.43 | FALSE |
19 | GTEx | Heart Left Ventricle | RP5-882C2.2 | 0.14 | 0.08 | lasso | 5 | 0.10 | 8.1e-06 | 6.8 | -7.1 | 1.5e-12 | -0.83 | 0.06 | 0.92 | FALSE |
20 | GTEx | Lung | TUBG2 | 0.08 | 0.02 | enet | 8 | 0.04 | 7.8e-04 | -5.0 | -5.2 | 1.5e-07 | -0.07 | 0.08 | 0.76 | FALSE |
21 | GTEx | Lung | CNTNAP1 | 0.06 | 0.00 | enet | 16 | 0.02 | 1.5e-02 | -4.1 | 5.1 | 2.8e-07 | 0.04 | 0.03 | 0.82 | FALSE |
22 | GTEx | Lung | ASB16 | 0.09 | 0.09 | enet | 15 | 0.07 | 3.4e-06 | 6.8 | -5.9 | 3.3e-09 | -0.81 | 0.09 | 0.91 | FALSE |
23 | GTEx | Lung | ASB16-AS1 | 0.15 | 0.12 | enet | 19 | 0.12 | 1.5e-09 | 6.8 | -5.6 | 1.9e-08 | -0.79 | 0.16 | 0.84 | FALSE |
24 | GTEx | Muscle Skeletal | TUBG2 | 0.12 | 0.09 | lasso | 8 | 0.10 | 1.1e-09 | 5.5 | -5.2 | 2.4e-07 | -0.08 | 0.00 | 1.00 | FALSE |
25 | GTEx | Muscle Skeletal | ASB16 | 0.07 | 0.06 | lasso | 3 | 0.06 | 2.9e-06 | 5.3 | 5.9 | 4.4e-09 | 0.80 | 0.10 | 0.90 | FALSE |
26 | GTEx | Nerve Tibial | TUBG2 | 0.26 | 0.28 | enet | 39 | 0.28 | 2.2e-20 | -4.3 | -5.1 | 3.0e-07 | -0.06 | 0.99 | 0.01 | FALSE |
27 | GTEx | Nerve Tibial | ASB16 | 0.12 | 0.07 | lasso | 5 | 0.07 | 7.5e-06 | 6.7 | -6.7 | 2.0e-11 | -0.87 | 0.19 | 0.81 | FALSE |
28 | GTEx | Nerve Tibial | RP11-400F19.8 | 0.10 | 0.03 | lasso | 3 | 0.02 | 8.2e-03 | 5.5 | -5.3 | 1.3e-07 | -0.11 | 0.14 | 0.26 | FALSE |
29 | GTEx | Nerve Tibial | ASB16-AS1 | 0.17 | 0.15 | lasso | 5 | 0.16 | 1.4e-11 | 6.8 | -6.4 | 1.4e-10 | -0.85 | 0.30 | 0.70 | FALSE |
30 | GTEx | Pancreas | CNTNAP1 | 0.13 | 0.09 | lasso | 7 | 0.09 | 9.1e-05 | 4.8 | 5.5 | 4.6e-08 | 0.09 | 0.16 | 0.60 | FALSE |
31 | GTEx | Pancreas | CTD-3193K9.3 | 0.12 | 0.07 | lasso | 5 | 0.07 | 5.7e-04 | 4.8 | 5.4 | 6.9e-08 | 0.09 | 0.13 | 0.50 | FALSE |
32 | GTEx | Pituitary | ASB16-AS1 | 0.19 | 0.17 | lasso | 4 | 0.22 | 3.8e-06 | 4.2 | -6.0 | 2.3e-09 | -0.79 | 0.16 | 0.63 | FALSE |
33 | GTEx | Skin Not Sun Exposed Suprapubic | TUBG2 | 0.15 | 0.13 | lasso | 5 | 0.12 | 4.0e-07 | 6.6 | -6.6 | 5.1e-11 | -0.07 | 0.00 | 1.00 | TRUE |
34 | GTEx | Skin Sun Exposed Lower leg | TUBG2 | 0.14 | 0.10 | enet | 25 | 0.12 | 4.9e-10 | -4.9 | -5.9 | 3.1e-09 | -0.06 | 0.01 | 0.99 | FALSE |
35 | GTEx | Skin Sun Exposed Lower leg | ASB16 | 0.11 | 0.03 | enet | 9 | 0.02 | 4.3e-03 | 6.4 | -5.3 | 9.5e-08 | -0.74 | 0.26 | 0.41 | FALSE |
36 | GTEx | Skin Sun Exposed Lower leg | ASB16-AS1 | 0.13 | 0.09 | lasso | 5 | 0.07 | 2.7e-06 | 6.4 | -6.4 | 1.6e-10 | -0.87 | 0.36 | 0.64 | FALSE |
37 | GTEx | Stomach | HSD17B1P1 | 0.10 | 0.04 | lasso | 3 | 0.04 | 6.9e-03 | 4.5 | -5.7 | 1.4e-08 | -0.07 | 0.09 | 0.38 | FALSE |
38 | GTEx | Testis | ASB16-AS1 | 0.35 | 0.25 | lasso | 5 | 0.23 | 1.0e-10 | 6.8 | -6.9 | 5.2e-12 | -0.90 | 0.07 | 0.93 | FALSE |
39 | GTEx | Thyroid | HSD17B1P1 | 0.04 | 0.00 | enet | 9 | 0.00 | 2.2e-01 | -5.0 | -5.9 | 3.5e-09 | -0.02 | 0.06 | 0.75 | FALSE |
40 | GTEx | Thyroid | RP5-882C2.2 | 0.10 | 0.07 | lasso | 3 | 0.07 | 2.9e-06 | 6.8 | -6.9 | 4.9e-12 | -0.85 | 0.03 | 0.96 | FALSE |
41 | GTEx | Thyroid | ASB16-AS1 | 0.14 | 0.06 | lasso | 2 | 0.04 | 5.4e-04 | 6.8 | -6.8 | 1.2e-11 | -0.89 | 0.10 | 0.82 | FALSE |
42 | GTEx | Whole Blood | ASB16 | 0.11 | 0.03 | enet | 24 | 0.03 | 6.3e-04 | 6.4 | -5.8 | 8.3e-09 | -0.63 | 0.15 | 0.48 | FALSE |
43 | GTEx | Whole Blood | ASB16-AS1 | 0.14 | 0.05 | lasso | 6 | 0.04 | 3.1e-04 | 6.8 | -6.9 | 4.2e-12 | -0.90 | 0.17 | 0.83 | FALSE |
44 | METSIM | Adipose | TUBG2 | 0.08 | 0.09 | lasso | 6 | 0.09 | 5.2e-13 | 4.3 | -5.3 | 1.2e-07 | -0.05 | 0.97 | 0.03 | FALSE |
45 | NTR | Blood | TUBG2 | 0.01 | 0.00 | blup | 247 | 0.01 | 4.0e-03 | -3.9 | 5.4 | 6.6e-08 | -0.02 | 0.52 | 0.02 | FALSE |
46 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ASB16 | 0.03 | 0.01 | enet | 4 | 0.02 | 1.2e-02 | 6.4 | -5.9 | 4.0e-09 | -0.82 | 0.02 | 0.48 | FALSE |
47 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C17orf65 | 0.03 | 0.00 | blup | 37 | 0.01 | 2.3e-02 | 6.8 | -7.6 | 3.0e-14 | -0.92 | 0.02 | 0.86 | TRUE |
48 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TUBG2 | 0.02 | 0.01 | lasso | 2 | 0.01 | 1.7e-02 | 5.5 | -5.7 | 1.4e-08 | -0.06 | 0.00 | 0.76 | FALSE |
49 | The Cancer Genome Atlas | Colon Adenocarcinoma | ASB16 | 0.05 | 0.06 | blup | 40 | 0.05 | 4.6e-04 | 6.6 | -6.8 | 1.1e-11 | -0.90 | 0.04 | 0.87 | FALSE |
50 | The Cancer Genome Atlas | Colon Adenocarcinoma | C17orf65 | 0.05 | 0.06 | blup | 38 | 0.05 | 4.2e-04 | 5.3 | -7.0 | 3.3e-12 | -0.90 | 0.12 | 0.74 | FALSE |
51 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ASB16 | 0.02 | 0.02 | blup | 39 | 0.02 | 3.8e-03 | 7.4 | -7.4 | 1.1e-13 | -0.90 | 0.01 | 0.52 | FALSE |
52 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C17orf65 | 0.03 | 0.01 | lasso | 10 | 0.02 | 3.6e-03 | 6.8 | -7.2 | 6.1e-13 | -0.82 | 0.03 | 0.87 | FALSE |
53 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ASB16 | 0.02 | 0.03 | blup | 40 | 0.03 | 1.3e-04 | 6.4 | -7.0 | 2.0e-12 | -0.89 | 0.14 | 0.84 | FALSE |
54 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C17orf65 | 0.05 | 0.05 | lasso | 2 | 0.05 | 2.5e-06 | 5.3 | -5.7 | 1.2e-08 | -0.78 | 0.15 | 0.84 | FALSE |
55 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ASB16 | 0.03 | 0.03 | lasso | 3 | 0.03 | 3.2e-04 | 6.3 | -6.4 | 1.5e-10 | -0.85 | 0.15 | 0.72 | FALSE |
56 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C17orf65 | 0.04 | 0.04 | blup | 37 | 0.03 | 1.4e-04 | 6.8 | -6.6 | 3.8e-11 | -0.86 | 0.19 | 0.78 | FALSE |
57 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HSD17B1 | 0.30 | 0.05 | enet | 14 | 0.06 | 2.8e-07 | -4.4 | -5.6 | 1.8e-08 | -0.06 | 0.44 | 0.53 | FALSE |
58 | The Cancer Genome Atlas | Lung Adenocarcinoma | ASB16 | 0.02 | 0.02 | lasso | 4 | 0.01 | 6.3e-03 | 6.8 | -6.1 | 1.1e-09 | -0.83 | 0.05 | 0.47 | FALSE |
59 | The Cancer Genome Atlas | Lung Adenocarcinoma | TUBG2 | 0.07 | 0.01 | enet | 7 | 0.02 | 2.2e-03 | 5.5 | -5.6 | 1.8e-08 | -0.09 | 0.00 | 0.87 | FALSE |
60 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ASB16 | 0.04 | 0.04 | lasso | 4 | 0.03 | 1.8e-04 | 7.6 | -7.5 | 6.8e-14 | -0.99 | 0.00 | 0.99 | FALSE |
61 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C17orf65 | 0.07 | 0.05 | lasso | 6 | 0.05 | 3.1e-06 | 6.8 | -6.7 | 2.4e-11 | -0.88 | 0.02 | 0.98 | FALSE |
62 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMC3IP | 0.02 | 0.02 | blup | 33 | 0.02 | 9.8e-04 | -5.0 | -5.9 | 3.3e-09 | -0.04 | 0.03 | 0.76 | FALSE |
63 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C17orf65 | 0.04 | 0.03 | blup | 39 | 0.03 | 2.7e-03 | 7.4 | -6.5 | 1.1e-10 | -0.89 | 0.01 | 0.92 | FALSE |
64 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C17orf65 | 0.09 | 0.02 | blup | 38 | 0.04 | 8.0e-03 | 6.8 | -6.1 | 1.1e-09 | -0.86 | 0.01 | 0.60 | FALSE |
65 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C17orf65 | 0.09 | 0.09 | enet | 8 | 0.08 | 2.9e-04 | 6.4 | -7.0 | 2.2e-12 | -0.91 | 0.03 | 0.92 | FALSE |
66 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HSD17B1 | 0.02 | 0.03 | blup | 30 | 0.03 | 4.0e-04 | -4.4 | -5.1 | 3.1e-07 | -0.04 | 0.41 | 0.20 | FALSE |
67 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TUBG2 | 0.04 | 0.02 | blup | 29 | 0.02 | 1.5e-03 | -4.9 | -5.6 | 2.1e-08 | -0.03 | 0.02 | 0.74 | FALSE |
68 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C17orf65 | 0.15 | 0.05 | blup | 37 | 0.09 | 1.7e-03 | 6.8 | -6.1 | 1.0e-09 | -0.83 | 0.02 | 0.63 | FALSE |
69 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C17orf65 | 0.07 | 0.02 | blup | 38 | 0.04 | 1.1e-02 | 6.3 | -7.2 | 6.6e-13 | -0.86 | 0.03 | 0.16 | FALSE |
70 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf65 | 0.03 | 0.03 | lasso | 7 | 0.03 | 3.8e-04 | 6.8 | -7.2 | 6.0e-13 | -0.94 | 0.02 | 0.94 | FALSE |
71 | The Cancer Genome Atlas | Thyroid Carcinoma | HSD17B1 | 0.05 | 0.07 | blup | 29 | 0.07 | 2.3e-07 | -4.1 | -5.6 | 1.8e-08 | -0.05 | 0.66 | 0.33 | FALSE |
72 | The Cancer Genome Atlas | Thyroid Carcinoma | TUBG2 | 0.20 | 0.13 | blup | 29 | 0.17 | 1.7e-16 | 5.5 | -5.6 | 1.8e-08 | -0.05 | 0.00 | 1.00 | FALSE |