Best TWAS P=1.64e-08 · Best GWAS P=1.48e-08 conditioned to 0.0166
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TRIM47 | 0.15 | 0.12 | enet | 13 | 0.14 | 2.8e-17 | 5.0 | -5.5 | 3.8e-08 | -0.74 | 0.02 | 0.98 | FALSE |
2 | GTEx | Brain Cerebellum | TRIM47 | 0.30 | 0.17 | lasso | 2 | 0.17 | 1.1e-05 | 5.4 | -5.4 | 6.0e-08 | -0.70 | 0.02 | 0.96 | FALSE |
3 | GTEx | Brain Hypothalamus | TRIM65 | 0.26 | 0.09 | lasso | 7 | 0.12 | 9.7e-04 | 4.4 | 5.4 | 7.9e-08 | 0.74 | 0.04 | 0.58 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | FBF1 | 0.14 | 0.13 | lasso | 3 | 0.13 | 1.2e-04 | 4.4 | 5.3 | 1.2e-07 | 0.85 | 0.01 | 0.91 | FALSE |
5 | GTEx | Cells Transformed fibroblasts | TRIM65 | 0.18 | 0.13 | lasso | 8 | 0.12 | 4.0e-09 | 5.4 | 5.2 | 2.4e-07 | 0.66 | 0.01 | 0.99 | FALSE |
6 | GTEx | Liver | GALK1 | 0.35 | 0.16 | lasso | 9 | 0.24 | 2.6e-07 | 4.8 | 5.3 | 1.3e-07 | 0.71 | 0.04 | 0.92 | FALSE |
7 | GTEx | Lung | RP11-552F3.10 | 0.12 | 0.02 | lasso | 2 | 0.03 | 4.4e-03 | 5.4 | -5.7 | 1.6e-08 | -0.70 | 0.02 | 0.45 | TRUE |
8 | GTEx | Muscle Skeletal | FBF1 | 0.07 | 0.02 | lasso | 4 | 0.02 | 8.0e-03 | 5.7 | 5.3 | 1.0e-07 | 0.99 | 0.00 | 0.99 | FALSE |
9 | GTEx | Nerve Tibial | TRIM65 | 0.25 | 0.10 | lasso | 6 | 0.16 | 8.7e-12 | 4.2 | 5.5 | 4.9e-08 | 0.79 | 0.03 | 0.97 | FALSE |
10 | GTEx | Skin Sun Exposed Lower leg | TRIM47 | 0.09 | 0.03 | lasso | 3 | 0.03 | 1.5e-03 | 5.2 | -5.4 | 7.4e-08 | -0.97 | 0.01 | 0.99 | FALSE |
11 | YFS | Blood | GALK1 | 0.05 | 0.04 | enet | 26 | 0.04 | 2.4e-13 | 5.0 | -5.1 | 2.8e-07 | -0.55 | 0.07 | 0.93 | FALSE |
12 | The Cancer Genome Atlas | Glioblastoma Multiforme | TRIM65 | 0.08 | 0.02 | enet | 7 | 0.04 | 1.9e-02 | 4.4 | 5.4 | 6.5e-08 | 0.90 | 0.01 | 0.74 | FALSE |
13 | The Cancer Genome Atlas | Lung Adenocarcinoma | TRIM47 | 0.04 | 0.01 | blup | 30 | 0.03 | 2.7e-04 | 5.4 | -5.6 | 2.3e-08 | -0.71 | 0.01 | 0.69 | FALSE |
14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FBF1 | 0.08 | 0.05 | blup | 41 | 0.04 | 1.1e-02 | 5.0 | 5.3 | 9.6e-08 | 0.88 | 0.01 | 0.84 | FALSE |
15 | The Cancer Genome Atlas | Thyroid Carcinoma | TRIM47 | 0.06 | 0.06 | blup | 30 | 0.06 | 1.6e-06 | 5.3 | -5.1 | 2.7e-07 | -0.91 | 0.01 | 0.99 | FALSE |