Best TWAS P=4.68e-18 · Best GWAS P=1.52e-18 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | LINC00674 | 0.12 | 0.13 | enet | 6 | 0.14 | 9.9e-12 | 7.4 | 7.5 | 7.1e-14 | 0.79 | 0.96 | 0.04 | FALSE |
2 | GTEx | Adipose Subcutaneous | SH3GL1P3 | 0.08 | 0.06 | lasso | 5 | 0.04 | 2.5e-04 | 7.4 | 7.3 | 2.7e-13 | 0.80 | 0.06 | 0.90 | FALSE |
3 | GTEx | Adipose Subcutaneous | RP11-147L13.8 | 0.28 | 0.09 | enet | 27 | 0.23 | 9.7e-19 | 4.8 | 5.3 | 8.9e-08 | 0.46 | 1.00 | 0.00 | FALSE |
4 | GTEx | Artery Aorta | LINC00674 | 0.12 | 0.00 | lasso | 5 | 0.01 | 1.5e-01 | 4.8 | 5.9 | 4.7e-09 | 0.58 | 0.08 | 0.33 | FALSE |
5 | GTEx | Brain Cerebellum | BPTF | 0.22 | -0.01 | lasso | 10 | -0.01 | 6.9e-01 | 7.0 | -7.4 | 1.4e-13 | -0.85 | 0.04 | 0.48 | FALSE |
6 | GTEx | Brain Cortex | C17orf58 | 0.34 | 0.09 | lasso | 6 | 0.13 | 2.4e-04 | 8.6 | 8.3 | 1.3e-16 | 0.95 | 0.03 | 0.96 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | LINC00674 | 0.30 | 0.31 | enet | 10 | 0.32 | 1.5e-24 | 7.4 | 8.0 | 8.7e-16 | 0.86 | 1.00 | 0.00 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | LRRC37A16P | 0.50 | 0.46 | lasso | 8 | 0.47 | 1.1e-38 | 7.4 | 7.6 | 2.2e-14 | 0.84 | 1.00 | 0.00 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | SH3GL1P3 | 0.26 | 0.31 | lasso | 7 | 0.31 | 1.5e-23 | 7.4 | 8.1 | 4.8e-16 | 0.90 | 0.99 | 0.01 | FALSE |
10 | GTEx | Colon Sigmoid | LINC00674 | 0.42 | 0.09 | lasso | 8 | 0.12 | 5.5e-05 | 7.5 | 7.0 | 3.3e-12 | 0.80 | 0.15 | 0.65 | FALSE |
11 | GTEx | Colon Sigmoid | RP11-147L13.8 | 0.12 | 0.20 | lasso | 3 | 0.15 | 4.4e-06 | 4.8 | 5.2 | 2.3e-07 | 0.51 | 0.36 | 0.44 | FALSE |
12 | GTEx | Esophagus Mucosa | LRRC37A16P | 0.11 | 0.06 | enet | 13 | 0.08 | 7.5e-06 | 5.5 | -5.8 | 5.7e-09 | -0.67 | 0.13 | 0.80 | FALSE |
13 | GTEx | Esophagus Muscularis | LINC00674 | 0.11 | 0.04 | lasso | 6 | 0.07 | 7.9e-05 | 4.8 | 7.2 | 9.0e-13 | 0.77 | 0.18 | 0.79 | FALSE |
14 | GTEx | Esophagus Muscularis | LRRC37A16P | 0.12 | 0.03 | enet | 21 | 0.02 | 3.2e-02 | 8.4 | 5.8 | 8.8e-09 | 0.64 | 0.02 | 0.79 | FALSE |
15 | GTEx | Heart Atrial Appendage | LINC00674 | 0.14 | 0.08 | lasso | 17 | 0.09 | 1.1e-04 | 4.8 | 7.0 | 3.2e-12 | 0.73 | 0.05 | 0.87 | FALSE |
16 | GTEx | Lung | LINC00674 | 0.14 | 0.03 | enet | 22 | 0.08 | 2.1e-06 | 8.4 | 6.3 | 2.7e-10 | 0.80 | 0.16 | 0.83 | FALSE |
17 | GTEx | Muscle Skeletal | LRRC37A16P | 0.14 | 0.04 | lasso | 5 | 0.08 | 3.3e-08 | 4.8 | -5.6 | 2.6e-08 | -0.59 | 0.99 | 0.00 | FALSE |
18 | GTEx | Nerve Tibial | LINC00674 | 0.09 | 0.01 | enet | 13 | 0.03 | 2.2e-03 | 4.8 | 5.9 | 4.2e-09 | 0.65 | 0.20 | 0.23 | FALSE |
19 | GTEx | Nerve Tibial | LRRC37A16P | 0.09 | 0.08 | lasso | 4 | 0.06 | 2.7e-05 | 7.5 | 7.6 | 2.8e-14 | 0.84 | 0.10 | 0.78 | FALSE |
20 | GTEx | Skin Sun Exposed Lower leg | BPTF | 0.10 | 0.01 | enet | 14 | 0.03 | 2.7e-03 | 7.4 | -6.6 | 4.0e-11 | -0.69 | 0.05 | 0.80 | FALSE |
21 | GTEx | Spleen | C17orf58 | 0.30 | -0.01 | lasso | 8 | -0.01 | 4.6e-01 | 4.6 | 6.5 | 1.0e-10 | 0.81 | 0.03 | 0.35 | FALSE |
22 | GTEx | Stomach | RP11-147L13.8 | 0.23 | -0.01 | enet | 9 | 0.01 | 8.1e-02 | 3.1 | 6.3 | 2.6e-10 | 0.57 | 0.04 | 0.18 | FALSE |
23 | GTEx | Thyroid | LINC00674 | 0.09 | 0.10 | enet | 16 | 0.12 | 4.0e-09 | 4.8 | 5.2 | 1.8e-07 | 0.61 | 0.57 | 0.39 | FALSE |
24 | GTEx | Thyroid | SH3GL1P3 | 0.08 | 0.00 | lasso | 3 | 0.00 | 2.8e-01 | 4.8 | 5.5 | 3.6e-08 | 0.56 | 0.05 | 0.45 | FALSE |
25 | YFS | Blood | KPNA2 | 0.01 | 0.01 | blup | 312 | 0.01 | 2.8e-04 | 7.5 | -7.9 | 3.3e-15 | -0.86 | 0.05 | 0.93 | FALSE |
26 | The Cancer Genome Atlas | Thyroid Carcinoma | C17orf58 | 0.02 | 0.02 | lasso | 2 | 0.01 | 1.8e-02 | 8.7 | 8.7 | 4.7e-18 | 1.00 | 0.00 | 0.76 | TRUE |